2,887 results on '"Boutron-Ruault, Marie-Christine"'
Search Results
52. Menopausal hormone therapy and risk of incident hypertension: role of the route of estrogen administration and progestogens in the E3N cohort
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Madika, Anne-Laure, MacDonald, Conor James, Fournier, Agnès, Mounier-Vehier, Claire, Béraud, Guillaume, and Boutron-Ruault, Marie-Christine
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- 2021
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53. Low socioeconomic position and neighborhood deprivation are associated with uncontrolled asthma in elderly
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Temam, Sofia, Chanoine, Sébastien, Bédard, Annabelle, Dumas, Orianne, Sanchez, Margaux, Boutron-Ruault, Marie-Christine, Siroux, Valérie, Rican, Stéphane, Varraso, Raphaëlle, and Le Moual, Nicole
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- 2019
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54. Association between blood metals mixtures concentrations and cognitive performance, and effect modification by diet in older US adults
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Laouali, Nasser, Benmarhnia, Tarik, Lanphear, Bruce P., Weuve, Jennifer, Mascari, Michael, Boutron-Ruault, Marie-Christine, and Oulhote, Youssef
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- 2022
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55. Single-Port One Anastomosis Duodenal Switch Revision of a Sleeve gastrectomy: First Description
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Pourcher, Guillaume, Chaouch, Mohamed Ali, Peyrottes, Arthur, Pantel, Louis, Ghedira, Abdessalem, Sindayigaya, Remy, Dabladji, Mourad, Beaussier, Marc, Boutron-Ruault, Marie-Christine, and Soubrane, Olivier
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- 2022
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56. Collaborateurs
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Abderrhamani, Amar, primary, Achamrah, Najate, additional, Allès, Benjamin, additional, Alligier, Maud, additional, Amouyal, Chloé, additional, André, Sébastien, additional, Andreelli, Fabrizio, additional, Antuna-Puente, Barbara, additional, Apfeldorfer, Gérard, additional, Arienzo, Roberto, additional, Arnulf, Isabelle, additional, Aron-Wisnewski, Judith, additional, Aubry, Estelle, additional, Avignon, Antoine, additional, Bachelot, Anne, additional, Barat, Pascal, additional, Barouki, Robert, additional, Bastard, Jean-Philippe, additional, Bastin, Marie, additional, Batisse, Thibaut, additional, Bauduceau, Bernard, additional, Bauters, Catherine, additional, Lassen, Pierre Bel, additional, Bellicha, Alice, additional, Bergouignan, Audrey, additional, Bienvenot, Rebecca, additional, Böhme, Philip, additional, Bonnefond, Amélie, additional, Bordier, Lyse, additional, Boirie, Yves, additional, Borel, Anne-Laure, additional, Bouchard, Philippe, additional, Bouillot, Jean-Luc, additional, Boutron-Ruault, Marie-Christine, additional, Brot-Laroche, Édith, additional, Caiazzo, Robert, additional, Carette, Claire, additional, Carriere, Caroline, additional, Carriere-Pazat, Audrey, additional, Casteilla, Louis, additional, Cassuto, Dominique-Adèle, additional, Charles, Marie-Aline, additional, Chapelot, Didier, additional, Charreire, Hélène, additional, Chevalier, Nicolas, additional, Chevallier, Jean-Marc, additional, Ciangura, Cécile, additional, Clément, Karine, additional, Coëffier, Moïse, additional, Cornet, Philippe, additional, Cortet, Christine, additional, Coupaye, Muriel, additional, Czernichow, Sébastien, additional, Dargent, Jérôme, additional, Delzenne, Nathalie, additional, Deruelle, Philippe, additional, Desport, Jean-Claude, additional, Desseigne, Magalie, additional, Detournay, Bruno, additional, Dharancy, Sébastien, additional, Disse, Emmanuel, additional, Donadille, Bruno, additional, Douillard, Claire, additional, Dubern, Béatrice, additional, Dubreuil, Sophie, additional, Duclos, Martine, additional, Duez, Hélène, additional, Dunoyer, Sophie, additional, Dupont, Charlotte, additional, Durlach, Vincent, additional, Durrer-Schutz, Dominique, additional, Duverne, Sophie, additional, Eburdery, Harold, additional, Espiard, Stéphanie, additional, Esser, Nathalie, additional, Everard, Amandine, additional, Faucher, Pauline, additional, Fayemendy, Philippe, additional, Fellahi, Soraya, additional, Fève, Bruno, additional, Fillon, Alicia, additional, Folope, Vanessa, additional, Fontanille, Isabelle, additional, Frelut, Marie-Laure, additional, Froguel, Philippe, additional, Gaborit, Bénédicte, additional, Gatta-Cherifi, Blandine, additional, Guillet, Christelle, additional, Grange, Laurent, additional, Grangeard, Catherine, additional, Gueorguieva, Iva, additional, Halimi, Serge, additional, Hanaire, Hélène, additional, Heide, Solveig, additional, Heude, Barbara, additional, Iceta, Sylvain, additional, Janmaat, Sonja, additional, Jéru, Isabelle, additional, Jésus, Pierre, additional, Joly, Anne-Sophie, additional, Jouret, Béatrice, additional, Julia, Chantal, additional, Julien-Sweerts, Sabrina, additional, Kim, Min Ji, additional, Ladsous, Miriam, additional, Lalau, Jean-Daniel, additional, Langin, Dominique, additional, Lascols, Olivier, additional, Lassailly, Guillaume, additional, de La Serre, Claire, additional, Laville, Martine, additional, Laye, Sophie, additional, Lecerf, Jean-Michel, additional, Leturque, Armelle, additional, Lévy, Rachel, additional, Lienard, Yasmine, additional, Losserand, Guillaume, additional, Maghroudi, Aïcha, additional, Magnan, Christophe, additional, Marcelin, Geneviève, additional, Marciniak, Camille, additional, Marre, Philippe, additional, Marty, Lucile, additional, Mathurin, Philippe, additional, Matta, Joane, additional, Mencia-Huerta, Matthieu, additional, Michaud, Andréanne, additional, Miramont, Vincent, additional, Mocquot, Caroline, additional, Monnery-Patris, Sandrine, additional, Montastier, Émilie, additional, Morigny, Pauline, additional, Mosbah, Héléna, additional, Negro, Nathalie, additional, Neyrinck, Audrey, additional, Oppert, Jean-Michel, additional, Daoud, Naïma Oukhouya, additional, Pacini, Filippo, additional, Paccou, Julien, additional, Paquot, Nicolas, additional, Pattou, François, additional, Péron-Le Lay, Soazig, additional, Peuteuil, Pierre, additional, Poghosyan, Tigran, additional, Poitou, Christine, additional, Poulain, Jean-Pierre, additional, Pourcher, Guillaume, additional, Quilliot, Didier, additional, Raison, Jocelyne, additional, Raucoules-Aimé, Marc, additional, Ribes, Gérard, additional, Rigal, Nathalie, additional, Ritz, Patrick, additional, Rives-Lange, Claire, additional, Riviere, Pauline, additional, Robert, Maud, additional, Rodriguez, Julie, additional, Romon, Monique, additional, Rose, Cindy, additional, Rozier, Romain, additional, de Saint Pol, Thibault, additional, Sanguignol, Frédéric, additional, Scheen, André, additional, Schlienger, Jean-Louis, additional, Sermondade, Nathalie, additional, Sebti, Yasmine, additional, Simon, Chantal, additional, Tappy, Luc, additional, Tauber, Maïté, additional, Thibault, Hélène, additional, Thivel, David, additional, Valet, Philippe, additional, Vantyghem, Marie-Christine, additional, Vatier, Camille, additional, Verges, Bruno, additional, Verkindt, Hélène, additional, Vialettes, Bernard, additional, Vigouroux, Corinne, additional, Walrand, Stéphane, additional, Waysfeld, Bernard, additional, Zammouri, Jamila, additional, Zermati, Jean-Philippe, additional, Ziegler, Olivier, additional, and Zucker, Jean-Daniel, additional
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- 2021
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57. Correlations between urinary concentrations and dietary intakes of flavonols in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Garro-Aguilar, Yaiza, Cayssials, Valerie, Achaintre, David, Boeing, Heiner, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, Thriskos, Paschalis, Masala, Giovanna, Grioni, Sara, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Huybrechts, Inge, Agudo, Antonio, Scalbert, Augustin, and Zamora-Ros, Raul
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- 2020
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58. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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Solans, Marta, Benavente, Yolanda, Saez, Marc, Agudo, Antonio, Jakszyn, Paula, Naudin, Sabine, Hosnijeh, Fatemeh Saberi, Gunter, Marc, Huybrechts, Inge, Ferrari, Pietro, Besson, Caroline, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Lasheras, Cristina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María Dolores, Ardanaz, Eva, Schmidt, Julie A., Vineis, Paolo, Riboli, Elio, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elisavet, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Skeie, Guri, Weiderpass, Elisabete, Jerkeman, Mats, Dias, Joana Alves, Späth, Florentin, Nilsson, Lena Maria, Dahm, Christina C., Overvad, Kim, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, de Sanjose, Silvia, Vermeulen, Roel, Nieters, Alexandra, and Casabonne, Delphine
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- 2020
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59. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk
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Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, and Vineis, Paolo
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Colo-Rectal Cancer ,Cancer ,Clinical Research ,Digestive Diseases ,Adult ,Aged ,Biomarkers ,Tumor ,Case-Control Studies ,Chromatography ,Liquid ,Colonic Neoplasms ,Colorectal Neoplasms ,Europe ,Female ,Humans ,Immunity ,Cellular ,Male ,Middle Aged ,Neopterin ,Odds Ratio ,Prospective Studies ,Rectal Neoplasms ,Sensitivity and Specificity ,T-Lymphocytes ,Helper-Inducer ,Tandem Mass Spectrometry ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years. These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
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- 2015
60. Dietary inflammatory index and type 2 diabetes risk in a prospective cohort of 70,991 women followed for 20 years: the mediating role of BMI
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Laouali, Nasser, Mancini, Francesca Romana, Hajji-Louati, Mariem, El Fatouhi, Douae, Balkau, Beverley, Boutron-Ruault, Marie-Christine, Bonnet, Fabrice, and Fagherazzi, Guy
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- 2019
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61. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Hammer Bech, Bodil, Overvad, Kim, Tjønneland, Anne, Petersen, Kristina E. N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernández, Elena, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallström, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, and Rinaldi, Sabina
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- 2019
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62. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
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Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat
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Biological Sciences ,Genetics ,Cancer ,Clinical Research ,Human Genome ,Prevention ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Chromosomes ,Human ,Pair 5 ,Computational Biology ,DNA Methylation ,Epigenesis ,Genetic ,Female ,Gene Expression Regulation ,Neoplastic ,Gene Frequency ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Membrane Proteins ,Neoplasm Proteins ,Neoplasms ,Odds Ratio ,Polymorphism ,Single Nucleotide ,Risk ,Telomerase ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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- 2014
63. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study
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Murphy, Neil, Ward, Heather A., Jenab, Mazda, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kvaskoff, Marina, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Dahm, Christina C., Jakszyn, Paula, Sánchez, Maria-Jose, Gil, Leire, Huerta, José M., Barricarte, Aurelio, Quirós, J. Ramón, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Gylling, Björn, Myte, Robin, Jirström, Karin, Berntsson, Jonna, Xue, Xiaonan, Riboli, Elio, Cross, Amanda J., and Gunter, Marc J.
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- 2019
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64. Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study
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Baumeister, Sebastian E., Schlesinger, Sabrina, Aleksandrova, Krasimira, Jochem, Carmen, Jenab, Mazda, Gunter, Marc J., Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Fournier, Agnès, Kühn, Tilman, Kaaks, Rudolf, Pischon, Tobias, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, La Vecchia, Carlo, Masala, Giovanna, Panico, Salvatore, Fasanelli, Francesca, Tumino, Rosario, Grioni, Sara, Bueno de Mesquita, Bas, Vermeulen, Roel, May, Anne M., Borch, Kristin B., Oyeyemi, Sunday O., Ardanaz, Eva, Rodríguez-Barranco, Miguel, Dolores Chirlaque López, María, Felez-Nobrega, Mireia, Sonestedt, Emily, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Perez-Cornago, Aurora, Ferrari, Pietro, Stepien, Magdalena, Freisling, Heinz, Tsilidis, Konstantinos K., Ward, Heather, Riboli, Elio, Weiderpass, Elisabete, and Leitzmann, Michael F.
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- 2019
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65. Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women
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Vedie, Anne‐Laure, Laouali, Nasser, Gelot, Amandine, Severi, Gianluca, Boutron‐Ruault, Marie‐Christine, and Rebours, Vinciane
- Abstract
Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women. The study included 96,594 women from the E3N prospective cohort, mean age: 49 years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow‐up. Cases were classified according to the International Classification of Diseases 10. Associations with passive and active smoking and effect modification by the ABO blood group were investigated with multivariable Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI). During a 24‐year median follow‐up, 346 incident PC cases were identified. Current smoking compared with never and former smoking (HR 1.51 [95% CI 1.08–2.10]), and passive smoking in childhood compared with no childhood exposure (HR 1.47 [95% CI 1.08–2.00]) were associated with increased PC risk, but not passive exposure in adulthood (HR 1.16 [95% CI 0.91–1.47]). Exposure to both passive smoking in childhood and current smoking was associated with a stronger risk (HR 2.80 [95% CI 1.42–5.52]) than exposure to both current smoking and passive smoking only in adulthood (HR 1.68 [95% CI 1.10–2.57]) compared with neither passive nor active smoking. Associations between active smoking and PC risk were strongest in the O or B groups, while associations with passive smoking were strongest in the A or AB blood groups, but the interaction terms were not statistically significant. Both current smoking and passive smoking in childhood were associated with PC risk, with a maximal risk of current smokers exposed to passive smoking during childhood. Possible interactions between blood groups and active or passive smoking must be investigated in a larger series.
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- 2024
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66. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
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Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E
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Cancer ,Aged ,Case-Control Studies ,Female ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Middle Aged ,Pancreatic Neoplasms ,Polymorphism ,Single Nucleotide ,White People ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
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- 2014
67. Genome-wide association study of survival in patients with pancreatic adenocarcinoma
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Wu, Chen, Kraft, Peter, Stolzenberg-Solomon, Rachael, Steplowski, Emily, Brotzman, Michelle, Xu, Mousheng, Mudgal, Poorva, Amundadottir, Laufey, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, Kooperberg, Charles, Petersen, Gloria M, Zheng, Wei, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Cao, Guangwen, Duell, Eric J, Elena, Joanne W, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Goran, Hutchinson, Amy, Hunter, David J, Jenab, Mazda, Jiang, Guoliang, Khaw, Kay-Tee, LaCroix, Andrea, Li, Zhaoshen, Mendelsohn, Julie B, Panico, Salvatore, Patel, Alpa V, Qian, Zhi Rong, Riboli, Elio, Sesso, Howard, Shen, Hongbing, Shu, Xiao-Ou, Tjonneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chengfeng, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen, Hoover, Robert, Hartge, Patricia, Fuchs, Charles S, Lin, Dongxin, and Wolpin, Brian M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Digestive Diseases ,Prevention ,Rare Diseases ,Pancreatic Cancer ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Adenocarcinoma ,Adult ,Aged ,Aged ,80 and over ,Asian People ,Biomarkers ,Tumor ,China ,Europe ,Female ,Follow-Up Studies ,Genome-Wide Association Study ,Humans ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Models ,Genetic ,Pancreatic Neoplasms ,Polymorphism ,Single Nucleotide ,Principal Component Analysis ,Proportional Hazards Models ,Protein Tyrosine Phosphatases ,Non-Receptor ,Survival Rate ,White People ,Cancer Genetics ,Molecular Epidemiology ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology ,Clinical sciences ,Nutrition and dietetics - Abstract
Background and objectiveSurvival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma.MethodsWe analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 additional patients from China (ChinaPC).ResultsIn the first stage of cases of European descent, the top-ranked loci were at chromosomes 11p15.4, 18p11.21 and 1p36.13, tagged by rs12362504 (p=1.63×10(-7)), rs981621 (p=1.65×10(-7)) and rs16861827 (p=3.75×10(-7)), respectively. 131 SNPs with p≤10(-5) were advanced to a joint analysis with cases from the ChinaPC study. In the joint analysis, the top-ranked SNP was rs10500715 (minor allele frequency, 0.37; p=1.72×10(-7)) on chromosome 11p15.4, which is intronic to the SET binding factor 2 (SBF2) gene. The HR (95% CI) for death was 0.74 (0.66 to 0.84) in PanScan I, 0.79 (0.65 to 0.97) in ChinaPC and 0.76 (0.68 to 0.84) in the joint analysis.ConclusionsGermline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts.
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- 2014
68. Investigation of common genetic risk factors between thyroid traits and breast cancer.
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Lucotte, Elise A, Asgari, Yazdan, Sugier, Pierre-Emmanuel, Karimi, Mojgan, Domenighetti, Cloé, Lesueur, Fabienne, Boland-Augé, Anne, Ostroumova, Evgenia, Vathaire, Florent de, Zidane, Monia, Guénel, Pascal, Deleuze, Jean-François, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Liquet, Benoît, and Truong, Thérèse
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- 2024
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69. P19-025-23 Macronutrient Composition of Plant-Based Diets and Breast Cancer Risk: The E3N Prospective Cohort Study
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Laouali, Nasser, primary, Koemel, Nicholas, additional, Shah, Sanam, additional, Senior, Alistair, additional, Severi, Gianluca, additional, Gill, Timothy, additional, Simpson, Stephen, additional, Raubenheimer, David, additional, Boutron-Ruault, Marie-Christine, additional, and Skilton, Michael, additional
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- 2023
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70. Diet and risk of diabetic retinopathy: a systematic review
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Dow, Courtney, Mancini, Francesca, Rajaobelina, Kalina, Boutron-Ruault, Marie-Christine, Balkau, Beverley, Bonnet, Fabrice, and Fagherazzi, Guy
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- 2018
71. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Zamora-Ros, Raul, Cayssials, Valerie, Jenab, Mazda, Rothwell, Joseph A., Fedirko, Veronika, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elissavet, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Weiderpass, Elisabete, Lukic, Marko, Sandanger, Torkjel M., Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ohlsson, Bodil, Nilsson, Lena Maria, Rutegård, Martin, Bueno-de-Mesquita, Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Bradbury, Kathryn, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Vineis, Paolo, and Scalbert, Augustin
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- 2018
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72. Endometriosis and the risk of skin cancer : a prospective cohort study
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Farland, Leslie V., Lorrain, Simon, Missmer, Stacey A., Dartois, Laureen, Cervenka, Iris, Savoye, Isabelle, Mesrine, Sylvie, Boutron-Ruault, Marie-Christine, and Kvaskoff, Marina
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- 2017
73. Patterns of cleaning product exposures using a novel clustering approach for data with correlated variables
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Marbac, Matthieu, Sedki, Mohammed, Boutron-Ruault, Marie-Christine, and Dumas, Orianne
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- 2018
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74. Asthma Medication Ratio Phenotypes in Elderly Women
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Chanoine, Sébastien, Pin, Isabelle, Sanchez, Margaux, Temam, Sofia, Pison, Christophe, Le Moual, Nicole, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Bousquet, Jean, Bedouch, Pierrick, Varraso, Raphaëlle, and Siroux, Valérie
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- 2018
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75. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4
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Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-de-Mesquita, H Bas, Shu, Xiao-Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S, Wactawski-Wende, Jean, Arslan, Alan A, Duell, Eric J, Fuchs, Charles S, Gallinger, Steven, Hartge, Patricia, Hoover, Robert N, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, Kooperberg, Charles, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Petersen, Gloria, Risch, Harvey A, Yu, Kai, Wolpin, Brian M, Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Buring, Julie E, Canzian, Federico, Chang, Kenneth, Chanock, Stephen J, Cotterchio, Michelle, Gaziano, J Michael, Giovanucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hoffman-Bolton, Judith A, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Patel, Alpa V, Rabe, Kari G, Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W, Yu, Herbert, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z
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Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Oncology and Carcinogenesis ,Cancer ,Digestive Diseases ,Genetics ,Pancreatic Cancer ,Prevention ,Rare Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Carbon ,Case-Control Studies ,Cohort Studies ,Germ-Line Mutation ,Humans ,Pancreatic Neoplasms ,Polymorphism ,Single Nucleotide ,United States ,Pancreatic cancer ,One-carbon metabolism ,Polymorphisms ,Biomarkers ,Public Health and Health Services ,Oncology and carcinogenesis - Abstract
PurposeThe evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed.MethodsUsing biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (
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- 2013
76. Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
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Elena, Joanne W, Steplowski, Emily, Yu, Kai, Hartge, Patricia, Tobias, Geoffrey S, Brotzman, Michelle J, Chanock, Stephen J, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Bao, Ying, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E, Gaziano, J Michael, Giovannucci, Edward L, Duell, Eric J, Hallmans, Göran, Howard, Barbara V, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kooperberg, Charles, Kraft, Peter, Mendelsohn, Julie B, Michaud, Dominique S, Palli, Domenico, Phillips, Lawrence S, Overvad, Kim, Patel, Alpa V, Sansbury, Leah, Shu, Xiao-Ou, Simon, Michael S, Slimani, Nadia, Trichopoulos, Dimitrios, Visvanathan, Kala, Virtamo, Jarmo, Wolpin, Brian M, Zeleniuch-Jacquotte, Anne, Fuchs, Charles S, Hoover, Robert N, and Gross, Myron
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Biomedical and Clinical Sciences ,Epidemiology ,Health Services and Systems ,Health Sciences ,Oncology and Carcinogenesis ,Rare Diseases ,Cancer ,Pancreatic Cancer ,Prevention ,Digestive Diseases ,Clinical Research ,Diabetes ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Good Health and Well Being ,Adenocarcinoma ,Adult ,Aged ,Aged ,80 and over ,Case-Control Studies ,Cohort Studies ,Diabetes Complications ,Diabetes Mellitus ,Female ,Humans ,Male ,Middle Aged ,Pancreatic Neoplasms ,Risk Factors ,Public Health and Health Services ,Oncology and carcinogenesis - Abstract
PurposeDiabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan).MethodsThe pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (
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- 2013
77. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, and Cross, Amanda J.
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- 2019
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78. Decline in Instrumental Activities of Daily Living over 4-Year: The Association with Hearing, Visual and Dual Sensory Impairments among Non-Institutionalized Women
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Bouscaren, N., Yildiz, H., Dartois, L., Vercambre, M. N., and Boutron-Ruault, Marie Christine
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- 2019
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79. Use of benzodiazepines and cardiovascular mortality in a cohort of women aged over 50 years
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Mesrine, Sylvie, Gusto, Gaëlle, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, and Fournier, Agnès
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- 2018
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80. Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study
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Freisling, Heinz, Noh, Hwayoung, Slimani, Nadia, Chajès, Véronique, May, Anne M., Peeters, Petra H., Weiderpass, Elisabete, Cross, Amanda J., Skeie, Guri, Jenab, Mazda, Mancini, Francesca R., Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Katzke, Verena A., Kühn, Tilman, Steffen, Annika, Boeing, Heiner, Tjønneland, Anne, Kyrø, Cecilie, Hansen, Camilla P., Overvad, Kim, Duell, Eric J., Redondo-Sánchez, Daniel, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Perez-Cornago, Aurora, Tsilidis, Konstantinos K., Aune, Dagfinn, Ward, Heather, Trichopoulou, Antonia, Naska, Androniki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Ericson, Ulrika, Sonestedt, Emily, Winkvist, Anna, Braaten, Tonje, Romieu, Isabelle, and Sabaté, Joan
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- 2018
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81. Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
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Li, Donghui, Duell, Eric J, Yu, Kai, Risch, Harvey A, Olson, Sara H, Kooperberg, Charles, Wolpin, Brian M, Jiao, Li, Dong, Xiaoqun, Wheeler, Bill, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Fuchs, Charles S, Gallinger, Steven, Gross, Myron, Hartge, Patricia, Hoover, Robert N, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Mandelson, Margaret T, Petersen, Gloria, Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Buring, Julie E, Canzian, Federico, Chang, Kenneth, Chanock, Stephen J, Cotterchio, Michelle, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hoffman Bolton, Judith A, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Patel, Alpa V, Rabe, Kari G, Riboli, Elio, Shu, Xiao-Ou, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Watters, Joanne, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey, and Stolzenberg-Solomon, Rachael Z
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Humans ,Pancreatic Neoplasms ,Genetic Predisposition to Disease ,Case-Control Studies ,Polymorphism ,Single Nucleotide ,Genome-Wide Association Study ,Polymorphism ,Single Nucleotide ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
Four loci have been associated with pancreatic cancer through genome-wide association studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to identify groups of genes or biological pathways enriched with disease-associated single-nucleotide polymorphisms (SNPs) whose individual effect sizes may be too small to be detected by standard single-locus methods. We used the adaptive rank truncated product method in a pathway-based analysis of GWAS data from 3851 pancreatic cancer cases and 3934 control participants pooled from 12 cohort studies and 8 case-control studies (PanScan). We compiled 23 biological pathways hypothesized to be relevant to pancreatic cancer and observed a nominal association between pancreatic cancer and five pathways (P < 0.05), i.e. pancreatic development, Helicobacter pylori lacto/neolacto, hedgehog, Th1/Th2 immune response and apoptosis (P = 2.0 × 10(-6), 1.6 × 10(-5), 0.0019, 0.019 and 0.023, respectively). After excluding previously identified genes from the original GWAS in three pathways (NR5A2, ABO and SHH), the pancreatic development pathway remained significant (P = 8.3 × 10(-5)), whereas the others did not. The most significant genes (P < 0.01) in the five pathways were NR5A2, HNF1A, HNF4G and PDX1 for pancreatic development; ABO for H.pylori lacto/neolacto; SHH for hedgehog; TGFBR2 and CCL18 for Th1/Th2 immune response and MAPK8 and BCL2L11 for apoptosis. Our results provide a link between inherited variation in genes important for pancreatic development and cancer and show that pathway-based approaches to analysis of GWAS data can yield important insights into the collective role of genetic risk variants in cancer.
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- 2012
82. The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk
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Berger, Eloïse, Maitre, Noële, Romana Mancini, Francesca, Baglietto, Laura, Perduca, Vittorio, Colineaux, Hélène, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Castagné, Raphaële, and Delpierre, Cyrille
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- 2020
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83. Variant ABO Blood Group Alleles, Secretor Status, and Risk of Pancreatic Cancer: Results from the Pancreatic Cancer Cohort Consortium
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Wolpin, Brian M, Kraft, Peter, Xu, Mousheng, Steplowski, Emily, Olsson, Martin L, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Stolzenberg-Solomon, Rachael Z, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Austin, Melissa A, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Göran, Hankinson, Susan E, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kooperberg, Charles, Mendelsohn, Julie B, Michaud, Dominique S, Overvad, Kim, Patel, Alpa V, Sanchéz, Maria-José, Sansbury, Leah, Shu, Xiao-Ou, Slimani, Nadia, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vineis, Paolo, Visvanathan, Kala, Virtamo, Jarmo, Wactawski-Wende, Jean, Watters, Joanne, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hartge, Patricia, and Fuchs, Charles S
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Digestive Diseases ,Cancer ,Clinical Research ,Genetics ,Rare Diseases ,Pancreatic Cancer ,Prevention ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,ABO Blood-Group System ,Alleles ,Cohort Studies ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genotype ,Glycosyltransferases ,Humans ,Odds Ratio ,Pancreatic Neoplasms ,Phenotype ,Polymorphism ,Single Nucleotide ,Medical and Health Sciences ,Epidemiology - Abstract
BackgroundSubjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk.MethodsWe determined ABO variants and secretor phenotype from single nucleotide polymorphisms in ABO and FUT2 genes in 1,533 cases and 1,582 controls from 12 prospective cohort studies. Adjusted odds ratios (OR) for pancreatic cancer were calculated using logistic regression.ResultsAn increased risk was observed in participants with A(1) but not A(2) alleles. Compared with subjects with genotype O/O, genotypes A(2)/O, A(2)/A(1), A(1)/O, and A(1)/A(1) had ORs of 0.96 (95% CI, 0.72-1.26), 1.46 (95% CI, 0.98-2.17), 1.48 (95% CI, 1.23-1.78), and 1.71 (95% CI, 1.18-2.47). Risk was similar for O01 and O02 variant O alleles. Compared with O01/O01, the ORs for each additional allele of O02, A(1), and A(2) were 1.00 (95% CI, 0.87-1.14), 1.38 (95% CI, 1.20-1.58), and 0.96 (95% CI, 0.77-1.20); P, O01 versus O02 = 0.94, A(1) versus A(2) = 0.004. Secretor phenotype was not an effect modifier (P-interaction = 0.63).ConclusionsAmong participants in a large prospective cohort consortium, ABO allele subtypes corresponding to increased glycosyltransferase activity were associated with increased pancreatic cancer risk.ImpactThese data support the hypothesis that ABO glycosyltransferase activity influences pancreatic cancer risk rather than actions of other nearby genes on chromosome 9q34.
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- 2010
84. Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
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Jacobs, Eric J, Chanock, Stephen J, Fuchs, Charles S, Lacroix, Andrea, McWilliams, Robert R, Steplowski, Emily, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Petersen, Gloria, Zheng, Wei, Agalliu, Ilir, Allen, Naomi E, Amundadottir, Laufey, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Clipp, Sandra, Dorronsoro, Miren, Gaziano, J Michael, Giovannucci, Edward L, Hankinson, Susan E, Hartge, Patricia, Hoover, Robert N, Hunter, David J, Jacobs, Kevin B, Jenab, Mazda, Kraft, Peter, Kooperberg, Charles, Lynch, Shannon M, Sund, Malin, Mendelsohn, Julie B, Mouw, Tracy, Newton, Christina C, Overvad, Kim, Palli, Domenico, Peeters, Petra HM, Rajkovic, Aleksandar, Shu, Xiao-Ou, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M, Yu, Kai, and Zeleniuch-Jacquotte, Anne
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Humans ,Pancreatic Neoplasms ,Genetic Predisposition to Disease ,Case-Control Studies ,Cohort Studies ,Genome-Wide Association Study ,Colo-Rectal Cancer ,Clinical Research ,Rare Diseases ,Aging ,Cancer ,Digestive Diseases ,Prostate Cancer ,Ovarian Cancer ,Pancreatic Cancer ,Breast Cancer ,Prevention ,Urologic Diseases ,2.1 Biological and endogenous factors ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
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- 2010
85. Anthropometric Measures, Body Mass Index, and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
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Arslan, Alan A, Helzlsouer, Kathy J, Kooperberg, Charles, Shu, Xiao-Ou, Steplowski, Emily, Bueno-de-Mesquita, H Bas, Fuchs, Charles S, Gross, Myron D, Jacobs, Eric J, Lacroix, Andrea Z, Petersen, Gloria M, Stolzenberg-Solomon, Rachael Z, Zheng, Wei, Albanes, Demetrius, Amundadottir, Laufey, Bamlet, William R, Barricarte, Aurelio, Bingham, Sheila A, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E, Chanock, Stephen J, Clipp, Sandra, Gaziano, J Michael, Giovannucci, Edward L, Hankinson, Susan E, Hartge, Patricia, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kraft, Peter, Lynch, Shannon M, Manjer, Jonas, Manson, Joann E, McTiernan, Anne, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Palli, Domenico, Rohan, Thomas E, Slimani, Nadia, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Wolpin, Brian M, Yu, Kai, Zeleniuch-Jacquotte, Anne, and Patel, Alpa V
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Obesity ,Cancer ,Clinical Research ,Nutrition ,Prevention ,Pancreatic Cancer ,Rare Diseases ,Digestive Diseases ,Adult ,Aged ,Aged ,80 and over ,Body Mass Index ,Case-Control Studies ,Female ,Humans ,Logistic Models ,Male ,Middle Aged ,Overweight ,Pancreatic Neoplasms ,Risk Factors ,Sex Distribution ,United States ,Waist Circumference ,Pancreatic Cancer Cohort Consortium ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services - Abstract
BackgroundObesity has been proposed as a risk factor for pancreatic cancer.MethodsPooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, or = 35.0). Models were adjusted for potential confounders.ResultsIn all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; P(trend) < .001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; P(trend) < .03), and in women it was 1.34 (95% CI, 1.05-1.70; P(trend) = .01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; P(trend) = .003) but less so in men.ConclusionsThese findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
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- 2010
86. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
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Petersen, Gloria M, Amundadottir, Laufey, Fuchs, Charles S, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Jacobs, Kevin B, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Risch, Harvey A, Zheng, Wei, Albanes, Demetrius, Bamlet, William R, Berg, Christine D, Boutron-Ruault, Marie-Christine, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Howard, Barbara, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Kaaks, Rudolf, Kooperberg, Charles, Krogh, Vittorio, Kurtz, Robert C, Lynch, Shannon M, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Parikh, Hemang, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Rodriguez, Laudina, Seminara, Daniela, Shu, Xiao-Ou, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wang, Zhaoming, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Fraumeni, Joseph F, Hoover, Robert N, Hartge, Patricia, and Chanock, Stephen J
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Chromosomes ,Human ,Pair 1 ,Chromosomes ,Human ,Pair 5 ,Chromosomes ,Human ,Pair 13 ,Humans ,Carcinoma ,Pancreatic Neoplasms ,Genetic Predisposition to Disease ,Case-Control Studies ,Cohort Studies ,Linkage Disequilibrium ,Polymorphism ,Single Nucleotide ,Genome-Wide Association Study ,Genetic Loci ,Rare Diseases ,Cancer ,Genetics ,Clinical Research ,Pancreatic Cancer ,Digestive Diseases ,Human Genome ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
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- 2010
87. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.
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Wolpin, Brian M, Kraft, Peter, Gross, Myron, Helzlsouer, Kathy, Bueno-de-Mesquita, H Bas, Steplowski, Emily, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Jacobs, Eric J, Lacroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Anderson, Garnet, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Clipp, Sandra, Gaziano, John Michael, Giovannucci, Edward L, Hallmans, Göran, Hankinson, Susan E, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin, Kooperberg, Charles, Lynch, Shannon M, Mendelsohn, Julie B, Michaud, Dominique S, Overvad, Kim, Patel, Alpa V, Rajkovic, Aleksandar, Sanchéz, Maria-José, Shu, Xiao-Ou, Slimani, Nadia, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vineis, Paolo, Virtamo, Jarmo, Wactawski-Wende, Jean, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hartge, Patricia, and Fuchs, Charles S
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Humans ,Pancreatic Neoplasms ,Genetic Predisposition to Disease ,ABO Blood-Group System ,Logistic Models ,Odds Ratio ,Risk Factors ,Cohort Studies ,Gene Frequency ,Genotype ,Alleles ,Aged ,Middle Aged ,Female ,Male ,Clinical Research ,Genetics ,Pancreatic Cancer ,Rare Diseases ,Digestive Diseases ,Cancer ,Prevention ,2.1 Biological and endogenous factors ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.
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- 2010
88. Nevi, Ambient Ultraviolet Radiation, and Thyroid Cancer Risk : A French Prospective Study
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Mesrine, Sylvie, Kvaskoff, Marina, Bah, Thierno, Wald, Lucien, Clavel-Chapelon, Françoise, and Boutron-Ruault, Marie-Christine
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- 2017
89. Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes : A collaborative re-analysis from the Ovarian Cancer Cohort Consortium
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Ose, Jennifer, Schock, Helena, Poole, Elizabeth M., Lehtinen, Matti, Visvanathan, Kala, Helzlsouer, Kathy, Buring, Julie E., Lee, I-Min, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Mattiello, Amalia, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Sánchez, María-José, Idahl, Annika, Travis, Ruth C., Rinaldi, Sabina, Merritt, Melissa A., Wentzensen, Nicolas, Tworoger, Shelley S., Kaaks, Rudolf, and Fortner, Renée T.
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- 2017
90. Associations between serum lipids and breast cancer incidence and survival in the E3N prospective cohort study
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His, Mathilde, Dartois, Laureen, Fagherazzi, Guy, Boutten, Anne, Dupré, Thierry, Mesrine, Sylvie, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, and Dossus, Laure
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- 2017
91. Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
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Nimptsch, Katharina, Song, Mingyang, Aleksandrova, Krasimira, Katsoulis, Michail, Freisling, Heinz, Jenab, Mazda, Gunter, Marc J., Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-De-Mesquita, H. Bas, Chong, Dawn Q., Jensen, Majken K., Wu, Chunsen, Overvad, Kim, Kühn, Tilman, Barrdahl, Myrto, Melander, Olle, Jirström, Karin, Peeters, Petra H., Sieri, Sabina, Panico, Salvatore, Cross, Amanda J., Riboli, Elio, Van Guelpen, Bethany, Myte, Robin, Huerta, José María, Rodriguez-Barranco, Miguel, Quirós, José Ramón, Dorronsoro, Miren, Tjønneland, Anne, Olsen, Anja, Travis, Ruth, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Severi, Gianluca, Bonet, Catalina, Palli, Domenico, Janke, Jürgen, Lee, Young-Ae, Boeing, Heiner, Giovannucci, Edward L., Ogino, Shuji, Fuchs, Charles S., Rimm, Eric, Wu, Kana, Chan, Andrew T., and Pischon, Tobias
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- 2017
92. Chronic Consumption of Artificial Sweetener in Packets or Tablets and Type 2 Diabetes Risk : Evidence from the E3N-European Prospective Investigation into Cancer and Nutrition Study
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Fagherazzi, Guy, Gusto, Gaëlle, Affret, Aurélie, Mancini, Francesca Romana, Dow, Courtney, Balkau, Beverley, Clavel-Chapelon, Françoise, Bonnet, Fabrice, and Boutron-Ruault, Marie-Christine
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- 2017
93. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium
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Lynch, Shannon M, Vrieling, Alina, Lubin, Jay H, Kraft, Peter, Mendelsohn, Julie B, Hartge, Patricia, Canzian, Federico, Steplowski, Emily, Arslan, Alan A, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Amundadottir, Laufey, Bingham, Sheila A, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Chanock, Stephen J, Clipp, Sandra, Hoover, Robert N, Jacobs, Kevin, Johnson, Karen C, Kooperberg, Charles, Luo, Juhua, Messina, Catherine, Palli, Domenico, Patel, Alpa V, Riboli, Elio, Shu, Xiao-Ou, Rodriguez Suarez, Laudina, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Tong, Elissa, Trichopoulos, Dimitrios, Virtamo, Jarmo, Ye, Weimin, Yu, Kai, Zeleniuch-Jacquette, Anne, Bueno-de-Mesquita, H Bas, and Stolzenberg-Solomon, Rachael Z
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Tobacco ,Digestive Diseases ,Cancer ,Pancreatic Cancer ,Rare Diseases ,Prevention ,Tobacco Smoke and Health ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Adenocarcinoma ,Adult ,Aged ,Aged ,80 and over ,Case-Control Studies ,Cohort Studies ,Female ,Humans ,Male ,Middle Aged ,Pancreatic Neoplasms ,Prospective Studies ,Risk ,Smoking ,Smoking Cessation ,United States ,pancreas ,pancreatic neoplasms ,smoking ,tobacco use cessation ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR) = 1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (> or =30 cigarettes/day: OR = 1.75, 95% CI: 1.27, 2.42), duration (> or =50 years: OR = 2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (> or =40 pack-years: OR = 1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis.
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- 2009
94. Plasma levels of OPN (ng/ml) in HCC Cases and matched Controls. from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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95. Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort
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Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary
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- 2023
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96. Data from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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97. Data from Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study
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Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bas Bueno-de-Mesquita, H., primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J.B., primary, Fedirko, Veronika, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Romaguera, Dora, primary, Overvad, Kim, primary, Østergaard, Jane Nautrup, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Morois, Sophie, primary, Masala, Giovanna, primary, Agnoli, Claudia, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Naska, Androniki, primary, Bamia, Christina, primary, Peeters, Petra H., primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Dorronsoro, Miren, primary, Huerta, Jose-María, primary, Barricarte, Aurelio, primary, Hallmans, Göran, primary, Palmqvist, Richard, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Allen, Naomi E., primary, Tsilidis, Konstantinos K, primary, and Pischon, Tobias, primary
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- 2023
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98. Supplementary Figures Legends from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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99. Cubic spline for the association between OPN levels and HCC from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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100. Supplementary Table 1 from Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study
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Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Jenab, Mazda, primary, Bas Bueno-de-Mesquita, H., primary, Jansen, Eugene, primary, van Duijnhoven, Fränzel J.B., primary, Fedirko, Veronika, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Riboli, Elio, primary, Romaguera, Dora, primary, Overvad, Kim, primary, Østergaard, Jane Nautrup, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Morois, Sophie, primary, Masala, Giovanna, primary, Agnoli, Claudia, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Vineis, Paolo, primary, Kaaks, Rudolf, primary, Lukanova, Annekatrin, primary, Trichopoulou, Antonia, primary, Naska, Androniki, primary, Bamia, Christina, primary, Peeters, Petra H., primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, María-José, primary, Dorronsoro, Miren, primary, Huerta, Jose-María, primary, Barricarte, Aurelio, primary, Hallmans, Göran, primary, Palmqvist, Richard, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Allen, Naomi E., primary, Tsilidis, Konstantinos K, primary, and Pischon, Tobias, primary
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- 2023
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