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51. Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children.

Author

Breton, E, Gagné-Ouellet, V, Thibeault, K, Guérin, R, Van Lieshout, Rj, Perron, P, Hivert, Mf, and Bouchard, L

Abstract

Studies have linked maternal pre-pregnancy obesity and hyperglycaemia with metabolic and neurodevelopmental complications in childhood. DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci. NEGR1 is involved in both energy balance and behaviour regulation. The aim of this study was to investigate associations between placental DNAm at the NEGR1 gene locus and childhood anthropometric and neurodevelopmental profiles in preschoolers. We analysed 276 mother-child dyads from Gen3G, a prospective birth cohort from Sherbrooke. At 3yo (40.4 ± 3.0 months), we measured body mass index (BMI) and the mothers reported on offspring neurobehavior using the Strengths and Difficulties Questionnaire (SDQ). We quantified DNAm levels at 30 CpGs at the NEGR1 locus using the MethylationEPIC Array in placental biopsies. DNAm at four CpGs located before NEGR1 second exon predicted child's BMI z-score (cg26153364: β=−0.16 ± 0.04; p=0.008, cg23166710: β=0.14 ± 0.08; p=0.03) and SDQ total score (cg04932878: β=0.22 ± 1.0; p= 3.0x10−4, cg16525738: β=−0.14 ± 0.18; p=0.01, cg23166710: β=−0.13 ± 0.36; p= 0.04), explaining 4.2% (p=0.003) and 7.3% (p= 1.3 x 10−4) of BMI-z and SDQ variances. cg23166710 was associated with both childhood phenotypes and correlated with NEGR1 placental expression (r=−0.22, p=0.04), suggesting its possible functional role. Together, maternal metabolic characteristics during pregnancy with NEGR1 DNAm levels explained 7.4% (p=4.2 x 10−4) of BMI-z and 14.2% (p=2.8 x 10−7) of SDQ variance at 3yo. This longitudinal study suggests that placental NEGR1 DNAm is associated with adiposity and neurodevelopment in preschool children and highlights its potential role in their comorbidity. [ABSTRACT FROM AUTHOR]

Published
2020
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53. Numerical and experimental studies of long-range magnetic dipolar interactions.

Author

Ledbetter, M. P., Savukov, I. M., Bouchard, L.-S., and Romalis, M. V.

Subjects
NUMERICAL analysis, MAGNETIC dipoles, DIPOLE moments, MAGNETIC fields, MAGNETOMETERS
Abstract

We describe several numerical methods developed to analyze the behavior of spin polarized liquids in the presence of long-range magnetic dipolar interactions and external field gradients. Two of the methods use a discrete lattice of spins. In the first we calculate the magnetic field from the lattice of spins directly, either in the rotating frame, or in the lab frame. In the second method we include the dipolar fields from linear magnetization gradients analytically and calculate the dipolar fields from higher order gradients in Fourier space, where they are a local function of the magnetization. In the third method the magnetization is expanded in a Taylor series and the dipolar fields are calculated analytically for each term. The results of these calculations are compared to experimental data, in which we use two superconducting quantum interference device magnetometers adjacent to a spherical sample of hyperpolarized liquid 129Xe to detect the evolution of magnetization gradients. In particular, we observe an increase by a factor of 100 of the spin dephasing time in a longitudinal magnetic field gradient due to dipolar interactions of the spins. While each of the numerical techniques has certain limitations, they are generally in agreement with each other and with experimental data. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2004
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57. (429) Baseline pain intensity and pain interference moderate effects of cognitive behavioral stress management on leukocyte inflammatory gene expression in women with breast cancer

Author

Taub, C., primary, Fisher, H., additional, Amiel, C., additional, Jutagir, D., additional, Bouchard, L., additional, Gudenkauf, L., additional, Blomberg, B., additional, Diaz, A., additional, Lechner, S., additional, Carver, C., additional, and Antoni, M., additional

Published
2017
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64. O075 : Assessment of the transjugular porto-systemic shunt (TIPSS) in the management of complications of noncirrhotic portal hypertension

Author

Bissonnette, J., primary, Garcia-Pagán, J.-C., additional, Albillos, A., additional, Ferreira, C., additional, Turon, F., additional, Téllez, L., additional, Nault, J.-C., additional, Abdel Rehim, M., additional, Sibert, A., additional, Perreault, P., additional, Bouchard, L., additional, Carbonell, N., additional, Trottier-Tellier, F., additional, Rautou, P.-E., additional, Valla, D., additional, and Plessier, A., additional

Published
2015
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69. Maternal and fetal genetic contribution to gestational weight gain

Author

Warrington, N M, Richmond, R, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R, Karhunen, V, Tiesler, C M T, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V W V, Lowe Jr, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Aagaard Nohr, E, Marina, L Santa, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R M, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T I A, Pennell, C, Felix, J F, Jacobsson, B, Geller, F, Evans, D M, and Lawlor, D A

Abstract

Background:Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG.Participants and methods:A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight).Results:Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10−8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG.Conclusions:We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG.

Published
2018
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78. Lexicomatique et Dictionnairiques: Actes des quatrièmes Journées scientifiques du Réseau ' Lexicologie, Terminologie, Traduction ' de l'AUF, Lyon (France), 28-30 septembre 1995

Author

Apresjan, J.-D., Blanc, E., Bouchard, L.-H., Bourigault, Didier, Breidt, E., Brunet, Etienne, Clas, A., Daille, B., Delisle, S., Deville, G., Emirkanian, L., Fontenelle, T., Habaili, H., Jouis, C., Knowles, F., Lelubre, X., Leroy-Turcan, I., Mathieu-Colas, M., Mustafa-Elhadi, W., Radanyi, D., Ramos, M.-A., Mantha, S., Segond, F., Sérasset, G., Szende, T., Taifi, M., Tanaka, K., Prince, V., Thomas, P., Tutin, A., Van Campenhoudt, M., Wooldridge, R., Herbigniaux, E., Ben Ahmed, M., and Agence Universitaire de la Francophonie (AUF)

Subjects
traduction, lexicologie, francophonie, terminologie, [SCCO.LING]Cognitive science/Linguistics, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, dictionnaire
Abstract

International audience; Peu à peu les sciences interviennent dans les dictionnaires. Le dictionnaire a de plus en plus une vocation sociale. Ce sont les Larousses et les Littrés qui donnent la mesure. Aujourd'hui, c'est l'informatique qui apporte sa contribution à l'élaboration de dictionnaires. L'ordinateur a bouleversé la lexicographie, la lexicologie et le dictionnaire même. Le dictionnaire s'appuie de plus en plus largement sur des bases de données. La répartition entre dictionnaire de langue général et dictionnaire spécialisé semble s'amenuiser, le nouveau type de dictionnaire étant en mesure de répondre en fonction des intérêts de l'usager. C'est l'ère du dictionnaire à la carte qui s'ouvre.

Published
1996

79. Lexicomatique et Dictionnairiques

Author

Apresjan, J.-D., Blanc, E., Bouchard, L.-H., Bourigault, Didier, Breidt, E., Brunet, Etienne, Clas, A., Daille, B., Delisle, S., Deville, G., Emirkanian, L., Fontenelle, T., Habaili, H., Jouis, C., Knowles, F., Lelubre, X., Leroy-Turcan, I., Mathieu-Colas, M., Mustafa-Elhadi, W., Radanyi, D., Ramos, M.-A., Mantha, S., Segond, F., Sérasset, G., Szende, T., Taifi, M., Tanaka, K., Prince, V., Thomas, P., Tutin, A., van Campenhoudt, M., Wooldridge, R., Herbigniaux, E., Ben Ahmed, M., and Deggis, Gilles

Subjects
traduction, lexicologie, francophonie, terminologie, [SCCO.LING] Cognitive science/Linguistics, dictionnaire, [SHS.LANGUE] Humanities and Social Sciences/Linguistics
Abstract

Peu à peu les sciences interviennent dans les dictionnaires. Le dictionnaire a de plus en plus une vocation sociale. Ce sont les Larousses et les Littrés qui donnent la mesure. Aujourd'hui, c'est l'informatique qui apporte sa contribution à l'élaboration de dictionnaires. L'ordinateur a bouleversé la lexicographie, la lexicologie et le dictionnaire même. Le dictionnaire s'appuie de plus en plus largement sur des bases de données. La répartition entre dictionnaire de langue général et dictionnaire spécialisé semble s'amenuiser, le nouveau type de dictionnaire étant en mesure de répondre en fonction des intérêts de l'usager. C'est l'ère du dictionnaire à la carte qui s'ouvre.

Published
1996

82. The KACTUS view on the 'O' word

Author

Schreiber, A.T., Wielinga, B.J., Jansweijer, W.N.H., Anjewierden, A.A., van Harmelen, F.A.H., Guarino, N., Skuce, D., Bouchard, L., and Onderzoeksinstituut Psychologie (FMG)

Published
1995

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