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54. Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders

Author

Novi, Giovanni, Bovis, Francesca, Capobianco, Marco, Frau, Jessica, Mataluni, Giorgia, Curti, Erica, Zuliani, Luigi, Cavalla, Paola, Brambilla, Laura, Annovazzi, Pietro, Repice, Anna Maria, Lanzillo, Roberta, Esposito, Sabrina, Benedetti, Luana, Maietta, Ilaria, Sica, Francesco, Buttari, Fabio, Malucchi, Simona, Fenu, Giuseppe, Landi, Doriana, Bosa, Chiara, Realmuto, Sabrina, Malentacchi, Maria, Granella, Franco, Signori, Alessio, Bonavita, Simona, Uccelli, Antonio, and Sormani, Maria Pia

Published
2019
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55. Cardiovascular autonomic individual profile of relapsing-remitting multiple sclerosis patients and risk of extending cardiac monitoring after first dose fingolimod

Author

Vanoli, Emilio, Montano, Nicola, De Angelis, Giuseppe, Badilini, Fabio, Mirabella, Massimiliano, Bonavita, Simona, Patti, Francesco, Bianco, Assunta, Sparaco, Maddalena, Chisari, Clara, Laroni, Alice, Frigerio, Francesca, Bartezaghi, Marta, Rossi, Silvia, Turrini, Renato, and Mancardi, Gianluigi

Published
2019
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56. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi

Published
2022
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57. Extending the Interval of Natalizumab Dosing: Is Efficacy Preserved?

Author

Clerico, Marinella, De Mercanti, Stefania Federica, Signori, Alessio, Iudicello, Marco, Cordioli, Cinzia, Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lavorgna, Luigi, Maniscalco, Giorgia Teresa, Curti, Erica, Lorefice, Lorena, Cocco, Eleonora, Nociti, Viviana, Mirabella, Massimiliano, Baroncini, Damiano, Mataluni, Giorgia, Landi, Doriana, Petruzzo, Martina, Lanzillo, Roberta, Gandoglia, Ilaria, Laroni, Alice, Frangiamore, Rita, Sartori, Arianna, Cavalla, Paola, Costantini, Gianfranco, Sormani, Maria Pia, and Capra, Ruggero

Published
2020
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61. Cost-Analysis of Telemedicine Interventions Compared with Traditional Care in the Management of Chronic Neurological Diseases: A Systematic Review.

Author

Maida, Elisabetta, Bresciamorra, Vincenzo, Triassi, Maria, Lanzillo, Roberta, Bonavita, Simona, and Lavorgna, Luigi

Subjects
NATIONAL health services, NEUROLOGICAL disorders, CHRONIC diseases, TELEMEDICINE, COGNITIVE therapy
Abstract

Background: Telemedicine has proven successful in relieving the burden of chronic neurological disorders from the national health care systems by ensuring a highly customized and effective management plan. Although many studies focus on assessing telemedicine effectiveness, little is known about the economic implications of telemedicine applications in chronic neurological diseases (CNDs). This issue could account for a lack of widespread implementation. Objective: Our study attempted to fill this gap by systematically reviewing scientific literature on the economic evaluation of telemedicine compared with traditional care in the management of CNDs. Methods: We performed a literature search on PubMed, Google Scholar, Scopus, Embase, and Medline. The inclusion criteria were as follows: (1) studies with a full cost-analysis; (2) randomized controlled trials; (3) studies comparing telemedicine interventions with traditional care; (4) articles focusing only on CNDs. Conversely, the exclusion criteria were as follows: (1) studies focusing on acute neurological conditions or other diseases and (2) study protocols, case report, duplicate articles, abstract only, books, letters to editors, and review articles. Results: Ten articles met the inclusion criteria. Three different approaches of telemedicine intervention could be identified: digital cognitive-behavioral therapy (CBT), motor telerehabilitation, and home monitoring and assessment devices. Conclusion: Cost-analysis showed an overall benefit in terms of both cost and effectiveness from the application of telemedicine instead of in-presence management in CNDs. Among the identified interventions, digital CBT proved to be the most cost-saving. However, promising results were also found in monitoring and assessment devices and in telerehabilitation. Definitely, however, more thorough, comprehensive, and high-quality economic evaluation studies are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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66. Correction to: Disability assessment using Google Maps

Author

Lavorgna, Luigi, Iaffaldano, Pietro, Abbadessa, Gianmarco, Lanzillo, Roberta, Esposito, Sabrina, Ippolito, Domenico, Sparaco, Maddalena, Cepparulo, Simone, Lus, Giacomo, Viterbo, Rosa, Clerico, Marinella, Trojsi, Francesca, Ragonese, Paolo, Borriello, Giovanna, Signoriello, Elisabetta, Palladino, Raffaele, Moccia, Marcello, Brigo, Francesco, Troiano, Maria, Tedeschi, Gioacchino, and Bonavita, Simona

Published
2022
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69. Validation of an iPad version of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) (P3-3.010)

Author

Sacca, Francesco, primary, Costabile, Teresa, additional, Signoriello, Elisabetta, additional, Lauro, Francesca, additional, Altieri, Manuela, additional, Ziello, Antonio Rosario, additional, d’Ambrosio, Alessandro, additional, Bisecco, Alvino, additional, Maniscalco, Giorgia Teresa, additional, Bonavita, Simona, additional, Gallo, Antonio, additional, Morra, Vincenzo Brescia, additional, Lus, Giacomo, additional, and Russo, Cinzia Valeria, additional

Published
2023
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71. Sexual Dysfunction in People with Multiple Sclerosis: The Role of Disease Severity, Illness Perception, and Depression

Author

Scandurra, Cristiano, primary, Rosa, Laura, additional, Carotenuto, Antonio, additional, Moccia, Marcello, additional, Arena, Sebastiano, additional, Ianniello, Antonio, additional, Nozzolillo, Agostino, additional, Turrini, Mariavittoria, additional, Streito, Lidia Mislin, additional, Abbadessa, Gianmarco, additional, Ferraro, Elisabetta, additional, Mattioli, Manuela, additional, Chiodi, Alessandro, additional, Maldonato, Nelson Mauro, additional, Bonavita, Simona, additional, Clerico, Marinella, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Patti, Francesco, additional, Lavorgna, Luigi, additional, Filippi, Massimo, additional, Borriello, Giovanna, additional, D’Amico, Emanuele, additional, Pozzilli, Carlo, additional, Brescia Morra, Vincenzo, additional, Petracca, Maria, additional, and Lanzillo, Roberta, additional

Published
2023
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73. Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis

Author

Zizolfi, Brunella, primary, Foreste, Virginia, additional, Bonavita, Simona, additional, Rubino, Valentina, additional, Ruggiero, Giuseppina, additional, Brescia Morra, Vincenzo, additional, Lanzillo, Roberta, additional, Carotenuto, Antonio, additional, Boscia, Francesca, additional, Taglialatela, Maurizio, additional, and Guida, Maurizio, additional

Published
2023
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74. Cladribine vs other drugs in MS: Merging randomized trial with real-life data

Author

Signori, Alessio, Saccà, Francesco, Lanzillo, Roberta, Maniscalco, Giorgia Teresa, Signoriello, Elisabetta, Repice, Anna Maria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Perini, Paola, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Pareja-Gutierrez, Lorena, La Gioia, Sara, Frigeni, Barbara, Barcella, Valeria, Frau, Jessica, Cocco, Eleonora, Fenu, Giuseppe, Clerici, Valentina Torri, Sartori, Arianna, Rasia, Sarah, Cordioli, Cinzia, Stromillo, Maria Laura, Di Sapio, Alessia, Pontecorvo, Simona, Grasso, Roberta, Barone, Stefania, Barrilà, Caterina, Russo, Cinzia Valeria, Esposito, Sabrina, Ippolito, Domenico, Landi, Doriana, Visconti, Andrea, and Sormani, Maria Pia

Published
2020
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77. Repetitive Transcranial Magnetic Stimulation (rTMS) in Mild Cognitive Impairment: Effects on Cognitive Functions—A Systematic Review.

Author

Sharbafshaaer, Minoo, Gigi, Ilaria, Lavorgna, Luigi, Esposito, Sabrina, Bonavita, Simona, Tedeschi, Gioacchino, Esposito, Fabrizio, and Trojsi, Francesca

Subjects
TRANSCRANIAL magnetic stimulation, MILD cognitive impairment, FUNCTIONAL magnetic resonance imaging, COGNITIVE ability, DEFAULT mode network, COGNITION disorders
Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique also used as a non-pharmacological intervention against cognitive impairment. The purpose of the present review was to summarize what is currently known about the effectiveness of rTMS intervention on different cognitive domains in patients with mild cognitive impairment (MCI) and to address potential neuromodulation approaches in combination with electroencephalography (EEG) and neuroimaging, especially functional magnetic resonance imaging (fMRI). In this systematic review, we consulted three main databases (PubMed, Science Direct, and Scopus), and Google Scholar was selected for the gray literature search. The PRISMA flowchart drove the studies' inclusion. The selection process ensured that only high-quality studies were included; after removing duplicate papers, explicit ratings were given based on the quality classification as high (A), moderate (B), or low (C), considering factors such as risks of bias, inaccuracies, inconsistencies, lack of direction, and publication bias. Seven full-text articles fulfilled the stated inclusion, reporting five double-blind, randomized, sham-controlled studies, a case study, and a randomized crossover trial. The results of the reviewed studies suggested that rTMS in MCI patients is safe and effective for enhancing cognitive functions, thus making it a potential therapeutic approach for MCI patients. Changes in functional connectivity within the default mode network (DMN) after targeted rTMS could represent a valuable indicator of treatment response. Finally, high-frequency rTMS over the dorsolateral prefrontal cortex (DLPFC) has been shown to significantly enhance cognitive functions, such as executive performance, together with the increase of functional connectivity within frontoparietal networks. The main limitations were the number of included studies and the exclusion of studies using intermittent theta-burst stimulation, used in studies on Alzheimer's disease. Therefore, neuroimaging techniques in combination with rTMS have been shown to be useful for future network-based, fMRI-guided therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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78. Pain, quality of life, and religiosity in people with multiple sclerosis

Author

Abbadessa Gianmarco, Bonavita Simona, Trojsi Francesca, Sparaco Maddalena, Lavorgna Luigi, Miele Giuseppina, Ippolito Domenico, Sparaco, Maddalena, Miele, Giuseppina, Abbadessa, Gianmarco, Ippolito, Domenico, Trojsi, Francesca, Lavorgna, Luigi, and Bonavita, Simona

Subjects
Multiple Sclerosis, Visual analogue scale, media_common.quotation_subject, Pain, Dermatology, Religiosity, Faith, Quality of life (healthcare), Surveys and Questionnaires, Spirituality, Humans, Medicine, Multiple sclerosi, media_common, Expanded Disability Status Scale, business.industry, Multiple sclerosis, General Medicine, medicine.disease, Prayer, Religion, Psychiatry and Mental health, Quality of Life, Neurology (clinical), business, Clinical psychology
Abstract

Purpose To investigate in multiple sclerosis (MS) patients, the relationship between pain and religiosity and to determine whether distinct dimensions of religiosity were associated with quality of life. Methods MS patients during clinical follow-up filled out the visual analogue scale for pain (VAS), the Mc Gill questionnaire (McGQ), the 36-Item Short Form Health Survey (SF-36), and the religious attitude scale (RAS), and expanded disability status scale (EDSS) was assessed. Results Ninety-two MS patients were enrolled, only two declined. There was a negative correlation between religious practice and faith and some domains of the SF-36 and a positive correlation between sensory, affective, and evaluative aspects of pain (at McGQ) and religious practices, and between evaluative aspects of pain (at McGQ) and faith. EDSS was significantly higher in practitioner believers compared to not practitioners. Conclusions More disabled MS patients, with worse quality of life, also due to physical pain, find a source of comfort in faith and religious practices. Pain is not relieved by prayer; therefore, we may guess that in MS the poor beneficial effect of religiosity and practice on pain perception may be linked to a structural/functional damage of neural circuits involved in reducing pain during prayer.

Published
2021

83. Alemtuzumab-Related Lymphocyte Subset Dynamics and Disease Activity or Autoimmune Adverse Events: Real-World Evidence

Author

Signoriello, Elisabetta, primary, Lus, Giacomo, additional, Saccà, Francesco, additional, Puthenparampil, Marco, additional, Coppola, Cinzia, additional, Di Pietro, Andrea, additional, Puoti, Gianfranco, additional, Criscuolo, Maria Cristina, additional, Foschi, Matteo, additional, Miele, Giuseppina, additional, Abbadessa, Gianmarco, additional, Brescia Morra, Vincenzo, additional, Gallo, Paolo, additional, Bonavita, Simona, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2023
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84. Long-Term Neuromodulatory Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Plasmatic Matrix Metalloproteinases (MMPs) Levels and Visuospatial Abilities in Mild Cognitive Impairment (MCI)

Author

Cirillo, Giovanni, primary, Pepe, Roberta, additional, Siciliano, Mattia, additional, Ippolito, Domenico, additional, Ricciardi, Dario, additional, de Stefano, Manuela, additional, Buonanno, Daniela, additional, Atripaldi, Danilo, additional, Abbadessa, Salvatore, additional, Perfetto, Brunella, additional, Sharbafshaaer, Minoo, additional, Sepe, Giovanna, additional, Bonavita, Simona, additional, Iavarone, Alessandro, additional, Todisco, Vincenzo, additional, Papa, Michele, additional, Tedeschi, Gioacchino, additional, Esposito, Sabrina, additional, and Trojsi, Francesca, additional

Published
2023
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87. Reduced Clinical Connectome Fingerprinting in Multiple Sclerosis Predicts Fatigue Severity

Author

Cipriano, Lorenzo, primary, Lopez, Emahnuel Troisi, additional, Liparoti, Marianna, additional, minino, roberta, additional, Romano, Antonella, additional, Polverino, Arianna, additional, Ciaramella, Francesco, additional, Ambrosanio, Michele, additional, Bonavita, Simona, additional, Jirsa, Viktor, additional, Sorrentino, Giuseppe, additional, and Sorrentino, Pierpaolo, additional

Published
2023
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89. Editorial: Disease modifying therapies in multiple sclerosis

Author

Bonavita, Simona, Ghajarzadeh, Mahsa, Lavorgna, Luigi, Bonavita, Simona, Ghajarzadeh, Mahsa, and Lavorgna, Luigi

Subjects
Neurology, disease modifying therapy, multiple sclerosi, pediatric onset multiple sclerosi, predictor, pregnancy, Neurology (clinical)
Published
2022

93. Unmet needs and gaps in the identification of secondary progression in multiple sclerosis: a Southern Italy healthcare professionals’ perspective

Author

Lus, Giacomo, primary, Bassano, Marco André, additional, Brescia Morra, Vincenzo, additional, Bonavita, Simona, additional, Gallo, Antonio, additional, Maimone, Davide, additional, Malerba, Laura, additional, Maniscalco, Giorgia Teresa, additional, Saccà, Francesco, additional, Salemi, Giuseppe, additional, Turrini, Renato, additional, Cottone, Salvatore, additional, Sessa, Edoardo, additional, Buccafusca, Maria, additional, and Grimaldi, Luigi Maria Edoardo, additional

Published
2022
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94. Clinical effectiveness of different natalizumab interval dosing schedules in a large Italian population of patients with multiple sclerosis

Author

Chisari, CLARA GRAZIA, Grimaldi Luigi Maria, Salemi, Giuseppe, Ragonese, Paolo, Iaffaldano, Pietro, Bonavita, Simona, Sparaco, Maddalena, Rovaris, Marco, D'Arma, Alessia, Lugaresi, Alessandra, Ferrò Maria Teresa, Grossi, Paola, Di Sapio Alessia, Cocco, Eleonora, Granella, Franco, Curti, Erica, Lepore, Vito, Trojano, Maria, Patti, Francesco, on behalf of the Italian MS Register Study Group, Chisari, Clara Grazia, Grimaldi, Luigi Maria, Salemi, Giuseppe, Ragonese, Paolo, Iaffaldano, Pietro, Bonavita, Simona, Sparaco, Maddalena, Rovaris, Marco, D'Arma, Alessia, Lugaresi, Alessandra, Ferrò, Maria Teresa, Grossi, Paola, Di Sapio, Alessia, Cocco, Eleonora, Granella, Franco, Curti, Erica, Lepore, Vito, Trojano, Maria, Patti, Francesco, Chisari C.G., Grimaldi L.M., Salemi G., Ragonese P., Iaffaldano P., Bonavita S., Sparaco M., Rovaris M., D'Arma A., Lugaresi A., Ferro M.T., Grossi P., DI Sapio A., Cocco E., Granella F., Curti E., Lepore V., Trojano M., and Patti F.

Subjects
Adult, medicine.medical_specialty, Population, multiple sclerosis, Drug Administration Schedule, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, natalizumab, 0302 clinical medicine, Natalizumab, Dosing schedules, Internal medicine, medicine, Humans, Immunologic Factors, natalizumab, risk stratification, multiple sclerosis, safety, effectiveness, Dosing, education, Proportional Hazards Models, Retrospective Studies, 030304 developmental biology, 0303 health sciences, education.field_of_study, Proportional hazards model, business.industry, Multiple sclerosis, Retrospective cohort study, Middle Aged, medicine.disease, Psychiatry and Mental health, Treatment Outcome, Italy, Tolerability, Settore MED/26 - Neurologia, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Abstract

IntroductionNatalizumab (NTZ) is one of the most effective treatment options for multiple sclerosis (MS) treatment. Our study aimed to evaluate the effectiveness of NTZ when administered according to the extended dosing strategy compared with standard 4-weekly administration in a large Italian MS population.Materials and methodsThis retrospective multicentre study included patients with relapsing-remitting MS (RR-MS) who received NTZ administrations between the 1 June 2012 and the 15 May 2018 and were followed by the ‘Italian MS Register’. All patients with MS were stratified into two groups based on NTZ administration schedule: standard interval dosing (SID) patients who received infusions on average from 28 to 32 days (median 30) and extended interval dosing (EID) including patients who have been infused with interval between 33 and 49 days (median 43). Clinical data were assessed at baseline (before starting NTZ), after 12 (T1) and 24 months (T2) of treatment.ResultsOut of 5231 patients with RR-MS screened, 2092 (mean age 43.2±12.0, 60.6% women) were enrolled. A total of 1254 (59.9%) received NTZ according to SID, and 838 (40.1%) according to EID. At 12 and 24 months, no differences in terms of annualised relapse rate and disability status were found between the two groups. Progression index and confirmed disability worsening were similar between the two groups.DiscussionThe use of NTZ with an extended interval schedule showed similar effectiveness compared with SID. Unchanged clinical efficacy of EID schedule may raise the question of a possible advantage in terms of tolerability and safety.

Published
2020

97. Validation of an iPad version of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)

Author

Costabile, Teresa, primary, Signoriello, Elisabetta, additional, Lauro, Francesca, additional, Altieri, Manuela, additional, Ziello, Antonio Rosario, additional, D’Ambrosio, Alessandro, additional, Bisecco, Alvino, additional, Maniscalco, Giorgia, additional, Bonavita, Simona, additional, Gallo, Antonio, additional, Morra, Vincenzo Brescia, additional, Lus, Giacomo, additional, Saccà, Francesco, additional, and Russo, Cinzia Valeria, additional

Published
2022
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100. Breakthrough SARS-CoV-2 infections in MS patients on disease-modifying therapies

Author

Schiavetti, Irene, primary, Cordioli, Cinzia, additional, Stromillo, Maria Laura, additional, Teresa Ferrò, Maria, additional, Laroni, Alice, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Pasquali, Livia, additional, Rilla, Maria Teresa, additional, Signoriello, Elisabetta, additional, Iodice, Rosa, additional, Di Sapio, Alessia, additional, Lanzillo, Roberta, additional, Caleri, Francesca, additional, Annovazzi, Pietro, additional, Conte, Antonella, additional, Liberatore, Giuseppe, additional, Ruscica, Francesca, additional, Docimo, Renato, additional, Bonavita, Simona, additional, Ulivelli, Monica, additional, Cavalla, Paola, additional, Patti, Francesco, additional, Ferraro, Diana, additional, Clerico, Marinella, additional, Immovilli, Paolo, additional, Di Filippo, Massimiliano, additional, Salvetti, Marco, additional, and Sormani, Maria Pia, additional

Published
2022
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