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51. Significant Increase in the Sensitivity of In-Flight Particle Detector Through Improvements and Innovation

Author

Pouliot, L., Blain, J., Nadeau, F., Lamontagne, M., Bisson, J. F., and Christian Moreau

Abstract

Innovation and improvements are described which yield a 20 fold increase in the signal-to-noise level of a two fiber, twin wavelength high speed pyrometer used for in-flight particle diagnostics. Examples are given of how these developments extend the application range of the technology to low temperature processes such as flame spraying of low emissivity materials.

Published
2001
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58. Stabilisation of industrial enzymes

Author

Lilly, M. D., primary, Barker, S. A., additional, Gray, C. J., additional, Lomath, A. W., additional, Atkinson, A., additional, Fullbrook, P. D., additional, Godfrey, T., additional, Kurowski, W. M., additional, Woodward, J., additional, Wiseman, A., additional, Bell, G., additional, Blain, J. A., additional, Patterson, J. D. E., additional, Todd, R., additional, and Hingley, S., additional

Published
2007
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65. Synthesis and Nonenzymatic Template-Directed Polymerization of 2'-Amino-2'-deoxythreose Nucleotides.

Author

Craig Blain, J., Ricardo, Alonso, and Szostak, Jack W.

Subjects
*POLYMERIZATION, *NUCLEOTIDES, *NUCLEIC acids, *NUCLEOSIDES, *GLYCALS, *HYDROXYL group, *PHOSPHORYLATION, *GUANINE
Abstract

Threose nucleic acid (TNA) is a potential alternative genetic material that may have played a role in the early evolution of life. We have developed a novel synthesis of 2'-amino modified TNA nucleosides (2'-NH2-TNA) based on a cycloaddition reaction between a glycal and an azodicarboxylate, followed by direct nucleosidation of the cycloadduct. Using this route, we synthesized the thymine and guanine 2'-NH2-TNA nucleosides in seven steps with 24% and 12% overall yield, respectively. We then phosphorylated the guanine nucleoside on the 3'-hydroxyl, activated the phosphate as the 2-methylimidazolide, and tested the ability of the activated nucleotide to copy C4 RNA, DNA, and TNA templates by nonenzymatic primer extension. We measured pseudo-first-order rate constants for the first nucleotide addition step of 1.5, 0.97, and 0.57 h–1 on RNA, DNA, and TNA templates, respectively, at pH 7.5 and 4 °C with 150 mM NaCl, 100 mM N-(hydroxylethyl)imidazole catalyst, and 5 mM activated nucleotide. The activated nucleotide hydrolyzed with a rate constant of 0.39 h–1, causing the polymerization reaction to stall before complete template copying could be achieved. These extension rates are more than 1 order of magnitude slower than those for amino-sugar ribonucleotides under the same conditions, and copying of the TNA template, which best represented a true self-copying reaction, was the slowest of all. The poor kinetics of 2'-NH2-TNA template copying could give insight into why TNA was ultimately not used as a genetic material by biological systems. [ABSTRACT FROM AUTHOR]

Published
2014
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67. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer.

Author

Shenglong Zhang, Craig Blain, J., Zielinska, Daria, Gryaznov, Sergei M., and Szostak, Jack W.

Subjects
*GENETIC polymorphisms, *CELL membranes, *RNA synthesis, *RIBONUCLEOTIDES, *POLYMERS
Abstract

Recent advances suggest that it may be possible to construct simple artificial cells from two subsystems: a self-replicating cell membrane and a self-replicating genetic polymer. Although multiple pathways for the growth and division of model protocell membranes have been characterized, no self-replicating genetic material is yet available. Nonenzymatic template-directed synthesis of RNA with activated ribonucleotide monomers has led to the copying of short RNA templates; however, these reactions are generally slow (taking days to weeks) and highly error prone. N3'-P5'-linked phosphoramidate DNA (3'-NP-DNA) is similar to RNA in its overall duplex structure, and is attractive as an alternative to RNA because the high reactivity of its corresponding monomers allows rapid and efficient copying of all four nucleobases on homopolymeric RNA and DNA templates. Here we show that both homopolymeric and mixed-sequence 3'-NP-DNA templates can be copied into complementary 3'-NP-DNA sequences. G:T and A:C wobble pairing leads to a high error rate, but the modified nucleoside 2-thiothymidine suppresses wobble pairing. We show that the 2-thiothymidine modification increases both polymerization rate and fidelity in the copying of a 3'-NP-DNA template into a complementary strand of 3'-NP-DNA. Our results suggest that 3'-NP-DNA has the potential to serve as the genetic material of artificial biological systems. [ABSTRACT FROM AUTHOR]

Published
2013
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69. Arizona board of examiners

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 57] : Vol 57 : Issue 10, Page(s) 1198, (dlps) volume: 0527912.0057.001, (dlps) article: 0527912.0057.001:507, http://quod.lib.umich.edu/t/text/accesspolicy.html

70. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 7, Page(s) 915, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:497, http://quod.lib.umich.edu/t/text/accesspolicy.html

71. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 6, Page(s) 788, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:443, http://quod.lib.umich.edu/t/text/accesspolicy.html

72. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 8, Page(s) 1016, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:535, http://quod.lib.umich.edu/t/text/accesspolicy.html

73. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 10, Page(s) 1202, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:592, http://quod.lib.umich.edu/t/text/accesspolicy.html

74. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 9, Page(s) 1107, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:565, http://quod.lib.umich.edu/t/text/accesspolicy.html

75. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 56] : Vol 56 : Issue 5, Page(s) 663, (dlps) volume: 0527912.0056.001, (dlps) article: 0527912.0056.001:360, http://quod.lib.umich.edu/t/text/accesspolicy.html

76. Arizona board of examiners

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 55] : Vol 55 : Issue 11, Page(s) 1203, (dlps) volume: 0527912.0055.001, (dlps) article: 0527912.0055.001:506, http://quod.lib.umich.edu/t/text/accesspolicy.html

77. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 50] : Vol 50 : Issue 11, Page(s) 1298, (dlps) volume: 0527912.0050.001, (dlps) article: 0527912.0050.001:804, http://quod.lib.umich.edu/t/text/accesspolicy.html

78. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 50] : Vol 50 : Issue 10, Page(s) 1159, (dlps) volume: 0527912.0050.001, (dlps) article: 0527912.0050.001:754, http://quod.lib.umich.edu/t/text/accesspolicy.html

79. Arizona Board of Examiners.

Author

Blain, J. Harvey, Blain, J. Harvey, Blain, J. Harvey, and Blain, J. Harvey

Abstract

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony., Vols. 1-13 are called "new series.", Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451., The Dental cosmos; a monthly record of dental science. [Vol. 50] : Vol 50 : Issue 5, Page(s) 547, (dlps) volume: 0527912.0050.001, (dlps) article: 0527912.0050.001:329, http://quod.lib.umich.edu/t/text/accesspolicy.html

100. La coulée directe de métaux

Author

Masounave, Jacques, Blain, J., and Essadiqi, E.

Abstract

La publication est conservée dans les Archives du CNRC., Séminaire ONU/CEE sur les nouvelles applications de l'acier face à la concurrence des matériaux de substitution, 2-6 mai 1988, Luxembourg

Published
1988

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