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51. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.

Author

Timmins, Iain R., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A., Brantley, Kristen D., Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V., Dossus, Laure, Eliassen, A. Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E., Houlston, Richard S., Joshu, Corinne E., and Kirsh, Victoria A.

Published
2024
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55. Validating a model for predicting breast cancer and nonbreast cancer death in women aged 55 years and older

Author

Wolfson, Emily A, primary, Schonberg, Mara A, additional, Eliassen, A Heather, additional, Bertrand, Kimberly A, additional, Shvetsov, Yurii B, additional, Rosner, Bernard A, additional, Palmer, Julie R, additional, LaCroix, Andrea Z, additional, Chlebowski, Rowan T, additional, Nelson, Rebecca A, additional, and Ngo, Long H, additional

Published
2023
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57. Mammographic density and risk of breast cancer by age and tumor characteristics

Author

Bertrand, Kimberly A, Tamimi, Rulla M, Scott, Christopher G, Jensen, Matthew R, Pankratz, V, Visscher, Daniel, Norman, Aaron, Couch, Fergus, Shepherd, John, Fan, Bo, Chen, Yunn-Yi, Ma, Lin, Beck, Andrew H, Cummings, Steven R, Kerlikowske, Karla, and Vachon, Celine M

Abstract

Abstract Introduction Understanding whether mammographic density (MD) is associated with all breast tumor subtypes and whether the strength of association varies by age is important for utilizing MD in risk models. Methods Data were pooled from six studies including 3414 women with breast cancer and 7199 without who underwent screening mammography. Percent MD was assessed from digitized film-screen mammograms using a computer-assisted threshold technique. We used polytomous logistic regression to calculate breast cancer odds according to tumor type, histopathological characteristics, and receptor (estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2)) status by age (51%) versus average density (11-25%). Women ages 2.1 cm) versus small tumors and positive versus negative lymph node status (P’s

Published
2013

58. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I, Skibola, Christine F, Joseph, Vijai, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S, Kelly, Rachel S, Lan, Qing, Teras, Lauren R, Chatterjee, Nilanjan, Chung, Charles C, Yeager, Meredith, Brooks-Wilson, Angela R, Hartge, Patricia, Purdue, Mark P, Birmann, Brenda M, Armstrong, Bruce K, Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B, Call, Timothy G, Shanafelt, Tait D, Novak, Anne J, Kay, Neil E, Liebow, Mark, Wang, Alice H, Smedby, Karin E, Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T, Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A, Jones, Brandt, Diver, W Ryan, Link, Brian K, Weiner, George J, Conde, Lucia, Bracci, Paige M, Riby, Jacques, Holly, Elizabeth A, Smith, Martyn T, Jackson, Rebecca D, Tinker, Lesley F, Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G, Achenbach, Sara J, Vachon, Celine M, Goldin, Lynn R, Strom, Sara S, Lanasa, Mark C, Spector, Logan G, Leis, Jose F, Cunningham, Julie M, Weinberg, J Brice, Morrison, Vicki A, Caporaso, Neil E, Norman, Aaron D, Linet, Martha S, De Roos, Anneclaire J, Morton, Lindsay M, Severson, Richard K, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, María-Dolores, Vermeulen, Roel CH, Travis, Ruth C, Giles, Graham G, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Spinelli, John J, and Bertrand, Kimberly A

Subjects
Cancer, Case-Control Studies, Chromosomes, Human, Pair 2, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Recombination, Genetic, Risk, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P=1.22×10(-14)), 18q21.33 (BCL2, P=7.76×10(-11)), 11p15.5 (C11orf21, P=2.15×10(-10)), 4q25 (LEF1, P=4.24×10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P=2.50×10(-9)), 9p21.3 (CDKN2B-AS1, P=1.27×10(-8)), 18q21.32 (PMAIP1, P=2.51×10(-8)), 15q15.1 (BMF, P=2.71×10(-10)) and 2p22.2 (QPCT, P=1.68×10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P=2.08×10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

Published
2013

59. Pesticide exposure and liver cancer : a review

Author

VoPham, Trang, Bertrand, Kimberly A., Hart, Jaime E., Laden, Francine, Brooks, Maria M., Yuan, Jian-Min, Talbott, Evelyn O., Ruddell, Darren, Chang, Chung-Chou H., and Weissfeld, Joel L.

Published
2017

60. Diabetes and breast cancer mortality in Black women

Author

Charlot, Marjory, Castro-Webb, Nelsy, Bethea, Traci N., Bertrand, Kimberly, Boggs, Deborah A., Denis, Gerald V., Adams-Campbell, Lucile L., Rosenberg, Lynn, and Palmer, Julie R.

Published
2017

66. Validating a model for predicting breast cancer and nonbreast cancer death in women aged 55 years and older.

Author

Wolfson, Emily A, Schonberg, Mara A, Eliassen, A Heather, Bertrand, Kimberly A, Shvetsov, Yurii B, Rosner, Bernard A, Palmer, Julie R, LaCroix, Andrea Z, Chlebowski, Rowan T, Nelson, Rebecca A, and Ngo, Long H

Subjects
BREAST cancer, CANCER patients, BREAST imaging, ONCOLOGY nursing, DISEASE risk factors, SURVIVAL analysis (Biometry), WOMEN'S health
Abstract

Background To support mammography screening decision making, we developed a competing-risk model to estimate 5-year breast cancer risk and 10-year nonbreast cancer death for women aged 55 years and older using Nurses' Health Study data and examined model performance in the Black Women's Health Study (BWHS). Here, we examine model performance in predicting 10-year outcomes in the BWHS, Women's Health Initiative-Extension Study (WHI-ES), and Multiethnic Cohort (MEC) and compare model performance to existing breast cancer prediction models. Methods We used competing-risk regression and Royston and Altman methods for validating survival models to calculate our model's calibration and discrimination (C index) in BWHS (n = 17 380), WHI-ES (n = 106 894), and MEC (n = 49 668). The Nurses' Health Study development cohort (n = 48 102) regression coefficients were applied to the validation cohorts. We compared our model's performance with breast cancer risk assessment tool (Gail) and International Breast Cancer Intervention Study (IBIS) models by computing breast cancer risk estimates and C statistics. Results When predicting 10-year breast cancer risk, our model's C index was 0.569 in BWHS, 0.572 in WHI-ES, and 0.576 in MEC. The Gail model's C statistic was 0.554 in BWHS, 0.564 in WHI-ES, and 0.551 in MEC; IBIS's C statistic was 0.547 in BWHS, 0.552 in WHI-ES, and 0.562 in MEC. The Gail model underpredicted breast cancer risk in WHI-ES; IBIS underpredicted breast cancer risk in WHI-ES and in MEC but overpredicted breast cancer risk in BWHS. Our model calibrated well. Our model's C index for predicting 10-year nonbreast cancer death was 0.760 in WHI-ES and 0.763 in MEC. Conclusions Our competing-risk model performs as well as existing breast cancer prediction models in diverse cohorts and predicts nonbreast cancer death. We are developing a website to disseminate our model. [ABSTRACT FROM AUTHOR]

Published
2024
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70. Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Author

Harvey, Summer V, primary, Wentzensen, Nicolas, additional, Bertrand, Kimberly, additional, Black, Amanda, additional, Brinton, Louise A, additional, Chen, Chu, additional, Costas, Laura, additional, Dal Maso, Luigino, additional, De Vivo, Immaculata, additional, Du, Mengmeng, additional, Garcia-Closas, Montserrat, additional, Goodman, Marc T, additional, Gorzelitz, Jessica, additional, Johnson, Lisa, additional, Lacey, James V, additional, Liao, Linda, additional, Lipworth, Loren, additional, Lissowska, Jolanta, additional, Miller, Anthony B, additional, O'Connell, Kelli, additional, O’Mara, Tracy A, additional, Ou, Xiao, additional, Palmer, Julie R, additional, Patel, Alpa V, additional, Paytubi, Sonia, additional, Pelegrina, Beatriz, additional, Petruzella, Stacey, additional, Prizment, Anna, additional, Rohan, Thomas, additional, Sandin, Sven, additional, Setiawan, Veronica Wendy, additional, Sinha, Rashmi, additional, Trabert, Britton, additional, Webb, Penelope M, additional, Wilkens, Lynne R, additional, Xu, Wanghong, additional, Yang, Hannah P, additional, Zheng, Wei, additional, and Clarke, Megan A, additional

Published
2023
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74. Supplementary Figure Legends from Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics

Author

Bertrand, Kimberly A., primary, Scott, Christopher G., primary, Tamimi, Rulla M., primary, Jensen, Matthew R., primary, Pankratz, V. Shane, primary, Norman, Aaron D., primary, Visscher, Daniel W., primary, Couch, Fergus J., primary, Shepherd, John, primary, Chen, Yunn-Yi, primary, Fan, Bo, primary, Wu, Fang-Fang, primary, Ma, Lin, primary, Beck, Andrew H., primary, Cummings, Steven R., primary, Kerlikowske, Karla, primary, and Vachon, Celine M., primary

Published
2023
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77. Data from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author

Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary

Published
2023
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78. Table S1 from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author

Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary

Published
2023
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79. Supplementary Table S1 from Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics

Author

Bertrand, Kimberly A., primary, Scott, Christopher G., primary, Tamimi, Rulla M., primary, Jensen, Matthew R., primary, Pankratz, V. Shane, primary, Norman, Aaron D., primary, Visscher, Daniel W., primary, Couch, Fergus J., primary, Shepherd, John, primary, Chen, Yunn-Yi, primary, Fan, Bo, primary, Wu, Fang-Fang, primary, Ma, Lin, primary, Beck, Andrew H., primary, Cummings, Steven R., primary, Kerlikowske, Karla, primary, and Vachon, Celine M., primary

Published
2023
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80. Supplementary Figure S2 from Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics

Author

Bertrand, Kimberly A., primary, Scott, Christopher G., primary, Tamimi, Rulla M., primary, Jensen, Matthew R., primary, Pankratz, V. Shane, primary, Norman, Aaron D., primary, Visscher, Daniel W., primary, Couch, Fergus J., primary, Shepherd, John, primary, Chen, Yunn-Yi, primary, Fan, Bo, primary, Wu, Fang-Fang, primary, Ma, Lin, primary, Beck, Andrew H., primary, Cummings, Steven R., primary, Kerlikowske, Karla, primary, and Vachon, Celine M., primary

Published
2023
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82. Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium : An individual-participant meta-analysis

Author

Brasky, Theodore M., Hade, Erinn M., Cohn, David E., Newton, Alison M., Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A., Cook, Linda S., De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L., Friedenreich, Christine M., Goodman, Marc T., Gorzelitz, Jessica, Ibiebele, Torukiri I., Krogh, Vittorio, Liao, Linda M., Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A., Palmer, Julie R., Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J., Setiawan, Veronica Wendy, Shu, Xiao-ou, Trabert, Britton, Brandt, Piet A. van den, Webb, Penelope M., Wentzensen, Nicolas, Wilkens, Lynne R., Wolk, Alicja, Yu, Herbert, Neuhouser, Marian L., Brasky, Theodore M., Hade, Erinn M., Cohn, David E., Newton, Alison M., Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A., Cook, Linda S., De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L., Friedenreich, Christine M., Goodman, Marc T., Gorzelitz, Jessica, Ibiebele, Torukiri I., Krogh, Vittorio, Liao, Linda M., Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A., Palmer, Julie R., Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J., Setiawan, Veronica Wendy, Shu, Xiao-ou, Trabert, Britton, Brandt, Piet A. van den, Webb, Penelope M., Wentzensen, Nicolas, Wilkens, Lynne R., Wolk, Alicja, Yu, Herbert, and Neuhouser, Marian L.

Abstract

Background. Limited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial can-cer risk; particularly among certain subgroups characterized by body mass and tumor pathology. Materials and methods. Data from 12 prospective cohort studies participating in the Epidemiology of Endome-trial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid in-takes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study -specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk. Results. Women with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were as-sociated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not dif-fer by cancer grade. Conclusion. Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly over-weight/obese women.(c) 2022 Elsevier Inc. All rights reserved.

Published
2023
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83. Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis

Author

Brasky, Theodore M, Hade, Erinn M, Cohn, David E, Newton, Alison M, Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A, Cook, Linda S, De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L, Friedenreich, Christine M, Goodman, Marc T, Gorzelitz, Jessica, Ibiebele, Torukiri I, Krogh, Vittorio, Liao, Linda M, Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A, Palmer, Julie R, Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J, Setiawan, Veronica Wendy, Shu, Xiao-Ou, Trabert, Britton, van den Brandt, Piet A, Webb, Penelope M, Wentzensen, Nicolas, Wilkens, Lynne R, Wolk, Alicja, Yu, Herbert, Neuhouser, Marian L, Brasky, Theodore M, Hade, Erinn M, Cohn, David E, Newton, Alison M, Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A, Cook, Linda S, De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L, Friedenreich, Christine M, Goodman, Marc T, Gorzelitz, Jessica, Ibiebele, Torukiri I, Krogh, Vittorio, Liao, Linda M, Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A, Palmer, Julie R, Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J, Setiawan, Veronica Wendy, Shu, Xiao-Ou, Trabert, Britton, van den Brandt, Piet A, Webb, Penelope M, Wentzensen, Nicolas, Wilkens, Lynne R, Wolk, Alicja, Yu, Herbert, and Neuhouser, Marian L

Abstract

BACKGROUND: Limited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial cancer risk; particularly among certain subgroups characterized by body mass and tumor pathology.MATERIALS AND METHODS: Data from 12 prospective cohort studies participating in the Epidemiology of Endometrial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid intakes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study-specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk.RESULTS: Women with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were associated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not differ by cancer grade.CONCLUSION: Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly overweight/obese women.

Published
2023

84. International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries

Author

McCormack, Valerie A., Burton, Anya, dos-Santos-Silva, Isabel, Hipwell, John H., Dickens, Caroline, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Lee, Charmaine Pei Ling, Chia, Kee-Seng, Ozmen, Vahit, Aribal, Mustafa Erkin, Flugelman, Anath Arzee, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, van Gils, Carla H., Wanders, Johanna O.P., Vinayak, Sudhir, Ndumia, Rose, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Won Lee, Jong, Kim, Jisun, Pereira, Ana, Garmendia, Maria Luisa, Sirous, Reza, Sirous, Mehri, Peplonska, Beata, Bukowska, Agnieszka, Tamimi, Rulla M., Bertrand, Kimberly, Nagata, Chisato, Kwong, Ava, Vachon, Celine, Scott, Christopher, Perez-Gomez, Beatriz, Pollan, Marina, Maskarinec, Gertraud, Giles, Graham, Hopper, John, Stone, Jennifer, Rajaram, Nadia, Teo, Soo-Hwang, Mariapun, Shivaani, Yaffe, Martin J., Schüz, Joachim, Chiarelli, Anna M., Linton, Linda, and Boyd, Norman F.

Published
2016
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87. Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach

Author

Gao, Guimin, Zhao, Fangyuan, Ahearn, Thomas U, Lunetta, Kathryn L, Troester, Melissa A, Du, Zhaohui, Ogundiran, Temidayo O, Ojengbede, Oladosu, Blot, William, Nathanson, Katherine L, Domchek, Susan M, Nemesure, Barbara, Hennis, Anselm, Ambs, Stefan, McClellan, Julian, Nie, Mark, Bertrand, Kimberly, Zirpoli, Gary, Yao, Song, Olshan, Andrew F, Bensen, Jeannette T, Bandera, Elisa V, Nyante, Sarah, Conti, David V, Press, Michael F, Ingles, Sue A, John, Esther M, Bernstein, Leslie, Hu, Jennifer J, Deming-Halverson, Sandra L, Chanock, Stephen J, Ziegler, Regina G, Rodriguez-Gil, Jorge L, Sucheston-Campbell, Lara E, Sandler, Dale P, Taylor, Jack A, Kitahara, Cari M, O’Brien, Katie M, Bolla, Manjeet K, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Michailidou, Kyriaki, Pharoah, Paul D P, Wang, Qin, Figueroa, Jonine, Biritwum, Richard, Adjei, Ernest, Wiafe, Seth, Ambrosone, Christine B, Zheng, Wei, Olopade, Olufunmilayo I, García-Closas, Montserrat, Palmer, Julie R, Haiman, Christopher A, and Huo, Dezheng

Subjects
Multifactorial Inheritance, Receptors, Estrogen/genetics, Breast Neoplasms, General Medicine, Breast Neoplasms/genetics, Receptors, Estrogen, Risk Factors, Genetics, Humans, Original Article, Female, Genetic Predisposition to Disease, Multifactorial Inheritance/genetics, Molecular Biology, Genetics (clinical), Genome-Wide Association Study
Abstract

Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remains relatively low. We aim to develop optimal PRSs for the prediction of overall and estrogen receptor (ER) subtype-specific breast cancer risk in AA women. The AA dataset comprised 9235 cases and 10 184 controls from four genome-wide association study (GWAS) consortia and a GWAS study in Ghana. We randomly divided samples into training and validation sets. We built PRSs using individual-level AA data by a forward stepwise logistic regression and then developed joint PRSs that combined (1) the PRSs built in the AA training dataset and (2) a 313-variant PRS previously developed in women of European ancestry. PRSs were evaluated in the AA validation set. For overall breast cancer, the odds ratio per standard deviation of the joint PRS in the validation set was 1.34 [95% confidence interval (CI): 1.27–1.42] with the area under receiver operating characteristic curve (AUC) of 0.581. Compared with women with average risk (40th–60th PRS percentile), women in the top decile of the PRS had a 1.98-fold increased risk (95% CI: 1.63–2.39). For PRSs of ER-positive and ER-negative breast cancer, the AUCs were 0.608 and 0.576, respectively. Compared with existing methods, the proposed joint PRSs can improve prediction of breast cancer risk in AA women.

Published
2022

93. Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes

Author

Yaghjyan, Lusine, Tamimi, Rulla M., Bertrand, Kimberly A., Scott, Christopher G., Jensen, Matthew R., Pankratz, V. Shane, Brandt, Kathy, Visscher, Daniel, Norman, Aaron, Couch, Fergus, Shepherd, John, Fan, Bo, Chen, Yunn-Yi, Ma, Lin, Beck, Andrew H., Cummings, Steven R., Kerlikowske, Karla, and Vachon, Celine M.

Published
2017
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95. A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Author

Ardisson Korat, Andres V., primary, Chiu, Yu-Han, additional, Bertrand, Kimberly A., additional, Zhang, Shumin, additional, Epstein, Mara M., additional, Rosner, Bernard A., additional, Chiuve, Stephanie, additional, Campos, Hannia, additional, Giovannucci, Edward L., additional, Chavarro, Jorge E., additional, and Birmann, Brenda M., additional

Published
2022
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96. Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis

Author

Brasky, Theodore M., primary, Hade, Erinn M., additional, Cohn, David E., additional, Newton, Alison M., additional, Petruzella, Stacey, additional, O'Connell, Kelli, additional, Bertrand, Kimberly A., additional, Cook, Linda S., additional, De Vivo, Immaculata, additional, Du, Mengmeng, additional, Freudenheim, Jo L., additional, Friedenreich, Christine M., additional, Goodman, Marc T., additional, Gorzelitz, Jessica, additional, Ibiebele, Torukiri I., additional, Krogh, Vittorio, additional, Liao, Linda M., additional, Lipworth, Loren, additional, Lu, Lingeng, additional, McCann, Susan, additional, O'Mara, Tracy A., additional, Palmer, Julie R., additional, Ponte, Jeanette, additional, Prizment, Anna, additional, Risch, Harvey, additional, Sandin, Sven, additional, Schouten, Leo J., additional, Setiawan, Veronica Wendy, additional, Shu, Xiao-ou, additional, Trabert, Britton, additional, van den Brandt, Piet A., additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Wilkens, Lynne R., additional, Wolk, Alicja, additional, Yu, Herbert, additional, and Neuhouser, Marian L., additional

Published
2022
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