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72 results on '"Berno, Tamara"'

51. Identification of a STAT3-miRNA Axis in T-LGL Leukemia

Author

Zambello, Renato, primary, Mariotti, Barbara, additional, Teramo, Antonella, additional, Rossato, Marzia, additional, Barilà, Gregorio, additional, Calabretto, Giulia, additional, Ercolin, Chiara, additional, Berno, Tamara, additional, Trentin, Livio, additional, Facco, Monica, additional, Semenzato, Gianpietro, additional, and Bazzoni, Flavia, additional

Published
2015
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55. Effect of low‐dose bortezomib on bone formation in smouldering multiple myeloma.

Author

Hildebrandt, Gerhard C., Berno, Tamara, Gurule, Andrea, Mohan, Meera, Yoon, Doonghoon, Salama, Mohamed, and Zangari, Maurizio

Subjects
*BORTEZOMIB, *MULTIPLE myeloma, *BONES, *X-rays, *BORONIC acids
Abstract

The article presents results of a study which examined the bone anabolic features of low-dose, intravenous bortezomib in patients suffering from smouldering multiple myeoloma. Bone density was evaluated using dual energy X-ray absorptiometry scan while assays of myeloma markers were conducted at the baseline.

Published
2019
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58. NK cells and their receptors in naive and rituximab-treated patients with anti-MAG polyneuropathy

Author

Benedetti, Luana, primary, Facco, Monica, additional, Franciotta, Diego, additional, Torre, Chiara Dalla, additional, Campagnolo, Marta, additional, Lucchetta, Marta, additional, Boscaro, Elisa, additional, Ermani, Mario, additional, Del Sette, Massimo, additional, Berno, Tamara, additional, Candiotto, Laura, additional, Zambello, Renato, additional, and Briani, Chiara, additional

Published
2013
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59. Could hypoxia increase the prevalence of thrombotic complications in polycythemia vera?

Author

Zangari, Maurizio, primary, Fink, Louis, additional, Tolomelli, Giulia, additional, Lee, Jasmine C.H., additional, Stein, Brady L., additional, Hickman, Kimberly, additional, Swierczek, Sabina, additional, Kelley, Todd W., additional, Berno, Tamara, additional, Moliterno, Alison R., additional, Spivak, Jerry L., additional, Gordeuk, Victor R., additional, and Prchal, Josef T., additional

Published
2013
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60. Lenalidomide long-term neurotoxicity.

Author

Torre, Chiara Dalla, Zambello, Renato, Cacciavillani, Mario, Campagnolo, Marta, Berno, Tamara, Salvalaggio, Alessandro, De March, Elena, Barilà, Gregorio, Lico, Albano, Lucchetta, Marta, Ermani, Mario, and Briani, Chiara

Published
2016
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61. Phase I Exploratory Study of IV Formulation of Panobinostat in Combination with Bortezomib in Relapsed/Refractory Multiple Myeloma Patients: Effect On Serum PTH and Gene Expression Profiling (GEP) Studies

Author

Zangari, Maurizio, primary, Berno, Tamara, additional, Talamo, Giampaolo, additional, Zhan, Xin, additional, Zhou, Wen, additional, Wang, He, additional, Yang, Ye, additional, Xia, Jiliang, additional, Zhou, Yi, additional, Pena, Karen, additional, Lujan, Leanne, additional, Kohan, Jessica, additional, Salama, Mohamed E, additional, and Zhan, Fenghuang, additional

Published
2012
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64. Intrinsic and Estrinsic Mechanism Contributes to Maintain the JAK/STAT Pathway Aberrantly Activated in T-Type Large Granular Lymphocyte Leukemia

Author

Zambello, Renato, primary, Teramo, Antonella, additional, Gattazzo, Cristina, additional, Passeri, Francesca, additional, Lico, Albana, additional, Tasca, Giulia, additional, Cabrelle, Anna, additional, Frezzato, Federica, additional, Martini, Veronica, additional, Trimarco, Valentina, additional, Berno, Tamara, additional, Boscaro, Elisa, additional, Facco, Monica, additional, Trentin, Livio, additional, and Semenzato, Gianpietro, additional

Published
2011
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69. Lenalidomide Therapy Is Associated with Improvement of Peripheral Neuropathy in Patient with Relapsed/Refractory Multiple Myeloma: Preliminary Results From a Single-Centre Prospective Non Interventional Study.

Author

Zambello, Renato, primary, Berno, Tamara, additional, Candiotto, Laura, additional, Torre, Chiara Dalla, additional, Campagnolo, Marta, additional, Lucchetta, Marta, additional, Trentin, Livio, additional, Briani, Chiara, additional, and Semenzato, Gianpietro, additional

Published
2009
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70. Phenotypic and functional analyses of dendritic cells in patients with lymphoproliferative disease of granular lymphocytes (LDGL)

Author

Zambello, Renato, primary, Berno, Tamara, additional, Cannas, Giovanna, additional, Baesso, Ilenia, additional, Binotto, Gianni, additional, Bonoldi, Emanuela, additional, Bevilacqua, Pierantonio, additional, Miorin, Marta, additional, Facco, Monica, additional, Trentin, Livio, additional, Agostini, Carlo, additional, and Semenzato, Gianpietro, additional

Published
2005
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71. Bortezomib, Thalidomide and Lenalidomide: Have They Really Changed the Outcome of Multiple Myeloma?

Author

Mian M, Tinelli M, DE March E, Turri G, Meneghini V, Pescosta N, Berno T, Marabese A, Mondello P, Patriarca F, Pizzolo G, Semenzato G, Cortelazzo S, and Zambello R

Subjects
Bortezomib therapeutic use, Humans, Lenalidomide, Leukemia, Plasma Cell surgery, Multiple Myeloma surgery, Prognosis, Retrospective Studies, Stem Cell Transplantation, Survival Analysis, Thalidomide therapeutic use, Treatment Outcome, Bortezomib administration & dosage, Leukemia, Plasma Cell drug therapy, Multiple Myeloma drug therapy, Thalidomide administration & dosage, Thalidomide analogs & derivatives
Abstract

Treatment of multiple myeloma (MM) has significantly improved, although the disease remains incurable. Prospective clinical trials evaluating the impact on outcome of new drugs such as proteasome inhibitors or immunomodulating agents are limited since they are not able to reflect the clinical routine and available retrospective data are not detailed enough to directly evaluate the value of new drugs. To address these information gaps, we performed a retrospective real-life analysis. We retrospectively assessed 949 patients treated for multiple myeloma or plasma cell leukemia at three Italian cancer centers in the years 1979-2014. Clinical features at the time of diagnosis were consistent with what was observed in clinical routine. A total of 39% of patients underwent high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). The median overall survival (OS) of the whole group was 5.4 years and ranged from 3.4 years for patients who did not receive at least one of the new drugs compared to 5.9 years in the other patients (p<0.001). The improvement in OS due to administration of new drugs was also observed among different prognostic sub-groups such as age, Durie and Salmon stage, international staging system and renal impairment. Availability of new drugs significantly improved survival of patients who underwent ASCT and also those who did not. In conclusion, we provided evidence that the advent of the new drugs drastically improved the outcome of patients with MM, also in cases with poor risk at the time of diagnosis. ASCT is still of major importance in the treatment of this disease. Nevertheless, MM remains incurable and new therapeutic approaches are warranted., (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2016

72. Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells.

Author

Gattazzo C, Teramo A, Passeri F, De March E, Carraro S, Trimarco V, Frezzato F, Berno T, Barilà G, Martini V, Piazza F, Trentin L, Facco M, Semenzato G, and Zambello R

Subjects
Adult, Aged, Aged, 80 and over, Chronic Disease, Cohort Studies, Disease Progression, Female, Flow Cytometry, Follow-Up Studies, Gene Rearrangement, Humans, Immunophenotyping, Killer Cells, Natural metabolism, Killer Cells, Natural pathology, Leukemia, Large Granular Lymphocytic metabolism, Leukemia, Large Granular Lymphocytic pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Receptors, Antigen, T-Cell genetics, Receptors, Antigen, T-Cell metabolism, Receptors, KIR genetics, T-Lymphocytes metabolism, T-Lymphocytes pathology, T-Lymphocytes, Cytotoxic metabolism, T-Lymphocytes, Cytotoxic pathology, Killer Cells, Natural immunology, Leukemia, Large Granular Lymphocytic immunology, Receptors, KIR metabolism, T-Lymphocytes immunology, T-Lymphocytes, Cytotoxic immunology
Abstract

The etiology of chronic large granular lymphocyte proliferations is largely unknown. Although these disorders are characterized by the expansion of different cell types (T and natural killer) with specific genetic features and abnormalities, several lines of evidence suggest a common pathogenetic mechanism. According to this interpretation, we speculated that in patients with natural killer-type chronic lymphoproliferative disorder, together with natural killer cells, also T lymphocytes undergo a persistent antigenic pressure, possibly resulting in an ultimate clonal T-cell selection. To strengthen this hypothesis, we evaluated whether clonal T-cell populations were detectable in 48 patients with killer immunoglobulin-like receptor-restricted natural killer-type chronic lymphoproliferative disorder. At diagnosis, in half of the patients studied, we found a clearly defined clonal T-cell population, despite the fact that all cases presented with a well-characterized natural killer disorder. Follow-up analysis confirmed that the TCR gamma rearrangements were stable over the time period evaluated; furthermore, in 7 patients we demonstrated the appearance of a clonal T subset that progressively matures, leading to a switch between killer immunoglobulin-like receptor-restricted natural killer-type disorder to a monoclonal T-cell large granular lymphocytic leukemia. Our results support the hypothesis that a common mechanism is involved in the pathogenesis of these disorders., (Copyright© Ferrata Storti Foundation.)

Published
2014
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