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51. Data from Microarray Analysis of Early Stage Serous Ovarian Cancers Shows Profiles Predictive of Favorable Outcome

Author

Berchuck, Andrew, primary, Iversen, Edwin S., primary, Luo, Jingqin, primary, Clarke, Jennifer P., primary, Horne, Hisani, primary, Levine, Douglas A., primary, Boyd, Jeff, primary, Alonso, Miguel A., primary, Secord, Angeles Alvarez, primary, Bernardini, Marcus Q., primary, Barnett, Jason C., primary, Boren, Todd, primary, Murphy, Susan K., primary, Dressman, Holly K., primary, Marks, Jeffrey R., primary, and Lancaster, Johnathan M., primary

Published
2023
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52. Figure S6 from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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53. Supplemental Figure legends from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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54. Supplementary Tables S1-S3 from Microarray Analysis of Early Stage Serous Ovarian Cancers Shows Profiles Predictive of Favorable Outcome

Author

Berchuck, Andrew, primary, Iversen, Edwin S., primary, Luo, Jingqin, primary, Clarke, Jennifer P., primary, Horne, Hisani, primary, Levine, Douglas A., primary, Boyd, Jeff, primary, Alonso, Miguel A., primary, Secord, Angeles Alvarez, primary, Bernardini, Marcus Q., primary, Barnett, Jason C., primary, Boren, Todd, primary, Murphy, Susan K., primary, Dressman, Holly K., primary, Marks, Jeffrey R., primary, and Lancaster, Johnathan M., primary

Published
2023
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55. Supplemental Tables from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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56. Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal

Author

Gervais, Nicole J., Gravelsins, Laura, Brown, Alana, Reuben, Rebekah, Perovic, Mateja, Karkaby, Laurice, Nicoll, Gina, Laird, Kazakao, Ramana, Shreeyaa, Bernardini, Marcus Q., Jacobson, Michelle, Velsher, Lea, Foulkes, William, Rajah, M. Natasha, Olsen, Rosanna K., Grady, Cheryl, Einstein, Gillian, Gervais, Nicole J., Gravelsins, Laura, Brown, Alana, Reuben, Rebekah, Perovic, Mateja, Karkaby, Laurice, Nicoll, Gina, Laird, Kazakao, Ramana, Shreeyaa, Bernardini, Marcus Q., Jacobson, Michelle, Velsher, Lea, Foulkes, William, Rajah, M. Natasha, Olsen, Rosanna K., Grady, Cheryl, and Einstein, Gillian

Abstract

Introduction: Women with early ovarian removal (<48 years) have an elevated risk for both late-life Alzheimers disease (AD) and insomnia, a modifiable risk factor. In early midlife, they also show reduced verbal episodic memory and hippocampal volume. Whether these reductions correlate with a sleep phenotype consistent with insomnia risk remains unexplored. Methods: We recruited thirty-one younger middleaged women with risk-reducing early bilateral salpingo-oophorectomy (BSO), fifteen of whom were taking estradiol-based hormone replacement therapy (BSO+ERT) and sixteen who were not (BSO). Fourteen age-matched premenopausal (AMC) and seventeen spontaneously peri-postmenopausal (SM) women who were similar to 10y older and not taking ERT were also enrolled. Overnight polysomnography recordings were collected at participants home across multiple nights (M=2.38 SEM=0.19), along with subjective sleep quality and hot flash ratings. In addition to group comparisons on sleep measures, associations with verbal episodic memory and medial temporal lobe volume were assessed. Results: Increased sleep latency and decreased sleep efficiency were observed on polysomnography recordings of those not taking ERT, consistent with insomnia symptoms. This phenotype was also observed in the older women in SM, implicating ovarian hormone loss. Further, sleep latency was associated with more forgetting on the paragraph recall task, previously shown to be altered in women with early BSO. Both increased sleep latency and reduced sleep efficiency were associated with smaller anterolateral entorhinal cortex volume. Discussion: Together, these findings confirm an association between ovarian hormone loss and insomnia symptoms, and importantly, identify an younger onset age in women with early ovarian removal, which may contribute to poorer cognitive and brain outcomes in these women., Funding Agencies|This work was supported by the Wilfred and Joyce Posluns Chair in Womens Brain Health and Aging (GE; WJP-150643), the Alzheimers Association Research Fellowship and Brain Canada Foundation (AARF-17-504715; NJG); Canadian Institutes of Health Research (CI [WJP-150643]; Joyce Posluns Chair in Womens Brain Health and Aging; Alzheimers Association Research Fellowship [AARF-17-504715]; Brain Canada Foundation [CNA 163902, MOP-143311]; Canadian Institutes of Health Research (CIHR); CIHR Masters award [310336]; Canadian Cancer Society; Ontario Brain Institute; Alzheimers Society of Canada; Womens Brain Health Initiative; NSERC Postgraduate Scholarships Doctoral Award; Ontario Graduate Scholarship award; General Motors Women in Science and Mathematics Award

Published
2023
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68. Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

Author

Le Page, Cécile, Rahimi, Kurosh, Köbel, Martin, Tonin, Patricia N., Meunier, Liliane, Portelance, Lise, Bernard, Monique, Nelson, Brad H., Bernardini, Marcus Q., Bartlett, John M. S., Bachvarov, Dimcho, Gotlieb, Walter H., Gilks, Blake, McAlpine, Jessica N., Nachtigal, Mark W., Piché, Alain, Watson, Peter H., Vanderhyden, Barbara, Huntsman, David G., Provencher, Diane M., and Mes-Masson, Anne-Marie

Published
2018
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69. The optimal time for surgery in women with serous ovarian cancer

Author

Stewart, Jocelyn M., Tone, Alicia A., Jiang, Haiyan, Bernardini, Marcus Q., Ferguson, Sarah, Laframboise, Stephane, Joan, Murphy K., Rosen, Barry, and May, Taymaa

Subjects
Chemotherapy -- Usage -- Patient outcomes, Cancer -- Chemotherapy, Ovarian cancer -- Care and treatment -- Patient outcomes, Health, Health care industry
Abstract

Background: Advanced high-grade serous ovarian carcinoma (HGSC) is commonly treated with surgery and chemotherapy. We investigated the survival of patients treated with primary or interval surgery at different times following [...]

Published
2016
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70. Leiomyosarcoma

Author

Devaud, Nicolas, primary, Vornicova, Olga, additional, Abdul Razak, Albiruni R., additional, Khalili, Korosh, additional, Demicco, Elizabeth G., additional, Mitric, Cristina, additional, Bernardini, Marcus Q., additional, and Gladdy, Rebecca A., additional

Published
2022
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73. Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

Author

Sudarshan, Deepthi, primary, Avvakumov, Nikita, additional, Lalonde, Marie-Eve, additional, Alerasool, Nader, additional, Joly-Beauparlant, Charles, additional, Jacquet, Karine, additional, Mameri, Amel, additional, Lambert, Jean-Philippe, additional, Rousseau, Justine, additional, Lachance, Catherine, additional, Paquet, Eric, additional, Herrmann, Lara, additional, Thonta Setty, Samarth, additional, Loehr, Jeremy, additional, Bernardini, Marcus Q., additional, Rouzbahman, Marjan, additional, Gingras, Anne-Claude, additional, Coulombe, Benoit, additional, Droit, Arnaud, additional, Taipale, Mikko, additional, Doyon, Yannick, additional, and Côté, Jacques, additional

Published
2022
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74. Implementation of a standardized voiding protocol after minimally invasive surgery: A quality improvement initiative

Author

Kim, Soyoun Rachel, primary, Laframboise, Stéphane, additional, Nelson, Gregg, additional, McCluskey, Stuart A., additional, Avery, Lisa, additional, Kujbid, Nastasia, additional, Zia, Aysha, additional, Bernardini, Marcus Q., additional, Ferguson, Sarah E., additional, May, Taymaa, additional, Hogen, Liat, additional, Cybulska, Paulina, additional, and Bouchard‐Fortier, Geneviève, additional

Published
2022
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75. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

Author

Sieh, Weiva, Köbel, Martin, Longacre, Teri A, Bowtell, David D, deFazio, Anna, Goodman, Marc T, Høgdall, Estrid, Deen, Suha, Wentzensen, Nicolas, Moysich, Kirsten B, Brenton, James D, Clarke, Blaise A, Menon, Usha, Gilks, C Blake, Kim, Andre, Madore, Jason, Fereday, Sian, George, Joshy, Galletta, Laura, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Matsuno, Rayna K, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Claus, Kalli, Kimberly R, Fridley, Brooke L, Keeney, Gary L, Vierkant, Robert A, Cunningham, Julie M, Brinton, Louise A, Yang, Hannah P, Sherman, Mark E, García-Closas, Montserrat, Lissowska, Jolanta, Odunsi, Kunle, Morrison, Carl, Lele, Shashikant, Bshara, Wiam, Sucheston, Lara, Jimenez-Linan, Mercedes, Driver, Kristy, Alsop, Jennifer, Mack, Marie, McGuire, Valerie, Rothstein, Joseph H, Rosen, Barry P, Bernardini, Marcus Q, Mackay, Helen, Oza, Amit, Wozniak, Eva L, Benjamin, Elizabeth, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Tinker, Anna V, Prentice, Leah M, Chow, Christine, Anglesio, Michael S, Johnatty, Sharon E, Chenevix-Trench, Georgia, Whittemore, Alice S, Pharoah, Paul DP, Goode, Ellen L, Huntsman, David G, and Ramus, Susan J

Published
2013
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77. Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Author

Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones, Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmana, Judith, Bandera, Elisa, V, Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia, V, Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A., Domchek, Susan M., Dork, Thilo, du Bois, Andreas, Durst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, ReneeT, Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Group, Opal Study, Group, AOCS, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Hogdall, Estrid, Hogdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th, John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., KimMatsuno, Rayna, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo, I, Olson, Sara H., Olsson, Hakan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamarina, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., BethTerry, Mary, Thomassen, Mads, Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Nieuwenhuysen, ElsVan, van Rensburg, Elizabeth J., Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., Pharoah, Paul D. P., Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones, Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmana, Judith, Bandera, Elisa, V, Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia, V, Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A., Domchek, Susan M., Dork, Thilo, du Bois, Andreas, Durst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, ReneeT, Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Group, Opal Study, Group, AOCS, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Hogdall, Estrid, Hogdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th, John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., KimMatsuno, Rayna, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo, I, Olson, Sara H., Olsson, Hakan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamarina, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., BethTerry, Mary, Thomassen, Mads, Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Nieuwenhuysen, ElsVan, van Rensburg, Elizabeth J., Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.

Abstract

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.

Published
2022
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81. Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes.

Author

Ren, Annie H., Filippou, Panagiota S., Soosaipillai, Antoninus, Dimitrakopoulos, Lampros, Korbakis, Dimitrios, Leung, Felix, Kulasingam, Vathany, Bernardini, Marcus Q., and Diamandis, Eleftherios P.

Subjects
OVARIAN cancer, EARLY detection of cancer, MUCINS, BIOMARKERS, DEVELOPED countries
Abstract

Ovarian cancer is the most lethal gynecological malignancy in developed countries. One of the key associations with the high mortality rate is diagnosis at late stages. This clinical limitation is primarily due to a lack of distinct symptoms and detection at the early stages. The ovarian cancer biomarker, CA125, is mainly effective for identifying serous ovarian carcinomas, leaving a gap in non-serous ovarian cancer detection. Mucin 13 (MUC13) is a transmembrane, glycosylated protein with aberrant expression in malignancies, including ovarian cancer. We explored the potential of MUC13 to complement CA125 as an ovarian cancer biomarker, by evaluating its ability to discriminate serous and non-serous subtypes of ovarian cancer at FIGO stages I–IV from benign conditions. We used our newly developed, high sensitivity ELISA to measure MUC13 protein in a large, well-defined cohort of 389 serum samples from patients with ovarian cancer and benign conditions. MUC13 and CA125 serum levels were elevated in malignant compared to benign cases (p<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of 0.74 (MUC13) and 0.76 (CA125). MUC13 concentrations were significantly higher in mucinous adenocarcinomas compared to benign controls (p=0.0005), with AUC of 0.80. MUC13 and CA125 showed significant elevation in early-stage cases (stage I–II) in relation to benign controls (p=0.0012 and p=0.014, respectively). We report the novel role of MUC13 as a serum ovarian cancer biomarker, where it could complement CA125 for detecting some subtypes of non-serous ovarian carcinoma and early-stage disease. [ABSTRACT FROM AUTHOR]

Published
2023
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84. Factors affecting surgical decision-making in carriers of BRCA1/2 pathogenic variants undergoing risk-reducing surgery at a dedicated hereditary ovarian cancer clinic.

Author

Jacobson, Michelle R. FRCS(C) NCMP, Walker, Melissa FRCSC, Ene, Gabrielle E.V. c, Firestone, Courtney, Bernardini, Marcus Q. FRCS(C), Allen, Lisa FRCS(C), Huszti, Ella, Sobel, Mara FRCS(C), Jacobson, Michelle R, Walker, Melissa, Ene, Gabrielle E V, Bernardini, Marcus Q, Allen, Lisa, and Sobel, Mara

Published
2022
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88. A prospective comparison of costs between robotics, laparoscopy, and laparotomy in endometrial cancer among women with Class III obesity or higher

Author

Kosa, Sarah D., primary, Ferguson, Sarah E., additional, Panzarella, Tony, additional, Lau, Susie, additional, Abitbol, Jeremie, additional, Samouëlian, Vanessa, additional, Giede, Christopher, additional, Steed, Helen, additional, Renkosinski, Benjamin, additional, Gien, Lilian T., additional, and Bernardini, Marcus Q., additional

Published
2021
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92. The Prevent Ovarian Cancer Program (POCP): Identification of Women at Risk for Ovarian Cancer Using Complementary Recruitment Approaches

Author

Tone, Alicia A., primary, McCuaig, Jeanna M., additional, Ricker, Nicole, additional, Boghosian, Talin, additional, Romagnuolo, Tina, additional, Stickle, Natalie, additional, Virtanen, Carl, additional, Zhang, Tong, additional, Kim, Raymond H., additional, Ferguson, Sarah E., additional, May, Taymaa, additional, Laframboise, Stephane, additional, Armel, Susan, additional, Demsky, Rochelle, additional, Volenik, Alexandra, additional, Stuart-McEwan, Terri, additional, Shaw, Patricia, additional, Oza, Amit, additional, Kamel-Reid, Suzanne, additional, Stockley, Tracy, additional, and Bernardini, Marcus Q., additional

Published
2021
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93. Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing

Author

Ferguson, Sarah E., Aronson, Melyssa, Pollett, Aaron, Eiriksson, Lua R., Oza, Amit M., Gallinger, Steven, Lerner-Ellis, Jordan, Alvandi, Zahra, Bernardini, Marcus Q., MacKay, Helen J., Mojtahedi, Golnessa, Tone, Alicia A., Massey, Christine, and Clarke, Blaise A.

Published
2014
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94. Maximizing cancer prevention through genetic navigation for Lynch syndrome detection in women with newly diagnosed endometrial and nonserous/nonmucinous epithelial ovarian cancer

Author

Kim, Soyoun Rachel, primary, Tone, Alicia, additional, Kim, Raymond H., additional, Cesari, Matthew, additional, Clarke, Blaise A., additional, Eiriksson, Lua, additional, Hart, Tae L., additional, Aronson, Melyssa, additional, Holter, Spring, additional, Lytwyn, Alice, additional, Maganti, Manjula, additional, Oldfield, Leslie, additional, Gallinger, Steven, additional, Bernardini, Marcus Q., additional, Oza, Amit M., additional, Djordjevic, Bojana, additional, Lerner‐Ellis, Jordan, additional, Van de Laar, Emily, additional, Vicus, Danielle, additional, Pugh, Trevor J., additional, Pollett, Aaron, additional, and Ferguson, Sarah E., additional

Published
2021
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95. Providers’ perspectives on reproductive decision-making amongst patients carrying a BRCA mutation: a needs assessment

Author

Dason, Shirin, primary, Drost, Leah, additional, Greenblatt, Ellen, additional, McMahon, Eileen, additional, Sobel, Mara, additional, Jacobson, Michelle, additional, Bernardini, Marcus Q, additional, Scheer, Adena, additional, Doshi, Tanya, additional, Wolff, Erika, additional, Han, Jinglan, additional, and Jones, Claire, additional

Published
2021
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98. Brief family history questionnaire to screen for Lynch syndrome in women with newly diagnosed non- serous, non-mucinous ovarian cancers.

Author

Soyoun Rachel Kim, Tone, Alicia, Kim, Raymond, Cesari, Matthew, Clarke, Blaise, Hart, Tae, Aronson, Melyssa, Holter, Spring, Lytwyn, Alice, Maganti, Manjula, Oldfield, Leslie, Gallinger, Steven, Bernardini, Marcus Q., Oza, Amit M., Djordjevic, Bojana, Lerner Ellis, Jordan, Van de Laar, Emily, Vicus, Danielle, Pugh, Trevor J., and Pollett, Aaron

Published
2022
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99. Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta‐analysis

Author

McAlpine, Jessica N., primary, Chiu, Derek S., additional, Nout, Remi A., additional, Church, David N., additional, Schmidt, Pascal, additional, Lam, Stephanie, additional, Leung, Samuel, additional, Bellone, Stefania, additional, Wong, Adele, additional, Brucker, Sara Y., additional, Lee, Cheng Han, additional, Clarke, Blaise A., additional, Huntsman, David G., additional, Bernardini, Marcus Q., additional, Ngeow, Joanne, additional, Santin, Alessandro D., additional, Goodfellow, Paul, additional, Levine, Douglas A., additional, Köbel, Martin, additional, Kommoss, Stefan, additional, Bosse, Tjalling, additional, Gilks, C. Blake, additional, and Talhouk, Aline, additional

Published
2021
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100. Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

Author

Sudarshan, Deepthi, primary, Avvakumov, Nikita, additional, Lalonde, Marie-Eve, additional, Alerasool, Nader, additional, Joly-Beauparlant, Charles, additional, Jacquet, Karine, additional, Mameri, Amel, additional, Lambert, Jean-Philippe, additional, Rousseau, Justine, additional, Lachance, Catherine, additional, Paquet, Eric, additional, Herrmann, Lara, additional, Setty, Samarth Thonta, additional, Loehr, Jeremy, additional, Bernardini, Marcus Q., additional, Rouzbahman, Marjan, additional, Gingras, Anne-Claude, additional, Coulombe, Benoit, additional, Droit, Arnaud, additional, Taipale, Mikko, additional, Doyon, Yannick, additional, and Côté, Jacques, additional

Published
2021
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