124 results on '"Bernard Harmegnies"'
Search Results
52. Etude acoustique de la production de glides dans la maladie de Parkinson
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Bernard Harmegnies, Myriam Piccaluga, Kathy Huet, Véronique Delvaux, and Virginie Roland
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lcsh:Social Sciences ,lcsh:H ,030507 speech-language pathology & audiology ,03 medical and health sciences ,0302 clinical medicine ,Philosophy ,0305 other medical science ,Humanities ,030217 neurology & neurosurgery - Abstract
Dans cet article, les résultats d’une étude acoustique sur la production de glides par des locuteurs atteints de la maladie de Parkinson et des locuteurs témoins sont présentés. Notre objectif est d’explorer la dynamique des articulateurs supralaryngés dans la MP, en particulier chez des locuteurs MP non dysarthriques. Nos résultats montrent des différences entre les deux groupes de sujets (locuteurs MP et témoins), en particulier en ce qui concerne l’amplitude des mouvements et la localisation dans le plan F1-F2. Nous notons également que ces différences se produisent en l’absence de dysarthrie, suggérant l’identification de phénomènes infracliniques dans la maladie de Parkinson.
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- 2020
53. Évolution du délai d’établissement du voisement (VOT) dans le vieillissement sain entre 40 et 80 ans
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Bernard Harmegnies, Myriam Piccaluga, Kathy Huet, Charlotte Vanderwaele, Véronique Delvaux, and Clémence Verhaegen
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lcsh:Social Sciences ,lcsh:H ,03 medical and health sciences ,0302 clinical medicine ,Philosophy ,05 social sciences ,0501 psychology and cognitive sciences ,Humanities ,030217 neurology & neurosurgery ,050105 experimental psychology - Abstract
Cette étude s’intéresse à l’évolution des capacités de production de la parole dans le vieillissement, dans une perspective lifespan. En effet, en plus de la diminution des capacités de production langagière, l’âge entraîne une réduction des capacités de contrôle moteur de la parole et une dégradation des structures oro-laryngées. Cependant, les effets de l’âge sur les capacités de production de la parole restent peu étudiés, particulièrement en langue française. Dans cette étude, nous nous centrons sur l’analyse du délai d’établissement du voisement (VOT), un paramètre important de la distinction entre les occlusives voisées et non voisées en français, et qui constitue un indice intéressant des capacités de coordination entre les gestes glottiques et supra-glottiques. Dans ce but, nous avons proposé une tâche de répétition de non-mots CVCV, comprenant les six consonnes occlusives du français /p,t,k,b,d,g/ à des participants de 40 à 80 ans, répartis en quatre groupes par tranches d’âges de 10 ans. Les résultats montrent la présence d’une diminution des valeurs de VOT ainsi que des pourcentages de voisement des premières consonnes voisées des non-mots après 60 ans. La présence d’effets délétères de l’âge sur les capacités d’initiation et de maintien du voisement des voisées du français est discutée.
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- 2020
54. Perception et production du trait de voisement chez l’enfant porteur d’implant(s) cochléaire(s)
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Sophie Fagniart, Véronique Delvaux, Chloé Doutriaux, Myriam Piccaluga, Anne Huberlant, Brigitte Charlier, Bernard Harmegnies, and Kathy Huet
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lcsh:Social Sciences ,lcsh:H ,03 medical and health sciences ,0302 clinical medicine ,General Medicine ,030223 otorhinolaryngology ,030217 neurology & neurosurgery - Abstract
Dans cette communication, nous décrirons une première étude visant à caractériser la perception et la production de consonnes occlusives voisées et non voisées auprès d’enfants présentant une surdité et porteurs d’implant(s) cochléaire(s), et d’enfants normo-entendants. Une tâche de perception catégorielle a ainsi montré des profils différents entre nos deux groupes d’enfants, les enfants implantés présentant des performances dans des tâches d’identification et de discrimination qui différaient de celles de leurs pairs entendants, pouvant suggérer une perception moins catégorielle. Au niveau productif, tandis que les deux groupes d’enfants présentaient des performances équivalentes en termes d’adéquation des productions voisées et non voisées, les analyses acoustiques réalisées sur les productions ont montré des valeurs de Voice Onset Time significativement plus courtes chez les enfants implantés.
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- 2020
55. Orofacial Strength and Voice Quality as Outcome of Levodopa Challenge Test in Parkinson Disease
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Jerome R. Lechien, Anissa Abderrakib, Kathy Huet, Serge Blecic, Bernard Harmegnies, Véronique Delvaux, Myriam Piccaluga, Sven Saussez, Bertil Delsaut, and Mohamad Khalife
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Adult ,Male ,Levodopa ,medicine.medical_specialty ,Oto-rhino-laryngologie ,muscle ,Voice Quality ,speech ,Diagnostic Techniques, Neurological ,Facial Muscles ,Disease ,Audiology ,aerodynamic ,acoustic ,Antiparkinson Agents ,03 medical and health sciences ,0302 clinical medicine ,Rating scale ,Neurologie ,Medicine ,Humans ,In patient ,Phonation ,Parkinson ,Muscle Strength ,Prospective Studies ,Voice Handicap Index ,levodopa ,030223 otorhinolaryngology ,Prospective cohort study ,Aged ,Aged, 80 and over ,Mouth ,business.industry ,voice ,Parkinson Disease ,Middle Aged ,Test (assessment) ,Otorhinolaryngology ,Female ,movement ,business ,strength ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objective: To assess the usefulness of orofacial strength and voice quality as assessment of response to levodopa challenge test (LCT) used in the diagnosis of early idiopathic Parkinson disease (IPD). Study Design: Controlled Prospective Study. Methods: From January 2014 to April 2019, patients with early IPD and healthy individuals were recruited and evaluated for clinical findings (Hoehn and Yahr scale; Unified Parkinson's Disease Rating Scale); Voice Handicap Index (VHI); grade of dysphonia, roughness, breathiness, asthenia, and strain and instability (GRBASI); maximal phonation time; phonation quotient; acoustic parameters; and orofacial muscle strength Oral Performance Instrument (IOPI; IOPI Medical, Woodinville, WA, USA) t) at baseline and 45 minutes after the levodopa intake (LCT). Results: A total of 32 IPD patients and 20 healthy individuals completed the study. Healthy individuals exhibited better VHI, grade of dysphonia, breathiness, asthenia, strain, instability, and acoustic measurements (noise-related, tremor, F0 short- and mid-term and intensity short-term parameters) than healthy subjects. The mean values of muscle strength of lips, cheeks, fundamental frequency (F0), highest F0, and shimmer significantly improved from pre- to post-LCT in IPD patients. Healthy individuals did not exhibit significant changes of orofacial strength and voice quality assessment from pre- to post-LCT. Significant associations were found between clinical, orofacial strength, and some aerodynamic and acoustic measurements. Conclusion: Orofacial strength and acoustic voice quality measurements may be used as objective outcomes of the LCT responsiveness in patients with early IPD. Level of Evidence: 3A. Laryngoscope, 2020., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2019
56. Validity and Reliability of the Reflux Sign Assessment
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Vinciane Muls, Camille Finck, Francois Mouawad, Sven Saussez, Bernard Harmegnies, Kathy Huet, Francois Bobin, Jerome R. Lechien, Sarah Remacle, Alexandra Rodriguez Ruiz, and Didier Dequanter
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Male ,medicine.medical_specialty ,Esophageal pH Monitoring ,Validity ,Laryngitis ,Endoscopy, Gastrointestinal ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Belgium ,medicine ,Laryngopharyngeal Reflux ,Humans ,030223 otorhinolaryngology ,business.industry ,Reflux ,Reproducibility of Results ,Proton Pump Inhibitors ,General Medicine ,Middle Aged ,medicine.disease ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Physical therapy ,Female ,Antacids ,Symptom Assessment ,business ,Sign (mathematics) ,Diet Therapy - Abstract
Objective: To develop and validate the Reflux Sign Assessment (RSA), a clinical instrument evaluating the physical findings of laryngopharyngeal reflux (LPR). Methods: A total of 106 patients completed a 3-month treatment based on the association of diet, pantoprazole, alginate, or magaldrate with the LPR characteristics (acid, nonacid, mixed). Forty-two asymptomatic individuals completed the study (control group). The RSA results and reflux finding score (RFS) were documented for the LPR patients at baseline and after treatment. Intrarater reliability was assessed through a test-retest blinded evaluation of signs (7-day intervals). Interrater reliability was assessed by comparing the RSA evaluations of three blinded otolaryngologists through Kendall’s W. Responsiveness to change was evaluated through a comparison of the baseline and 3-month posttreatment findings. The RSA cutoffs for determining the presence and absence of LPR were examined by receiver operating characteristic (ROC) analysis. Results: A total of 102 LPR patients completed the study (68 females). The mean age was 53 years. The mean RSA at baseline was 25.95 ± 9.58; it significantly improved to 18.96 ± 7.58 after 3 months of therapy ( P 14 may be suggestive of LPR. Conclusion: The RSA is a complete clinical instrument evaluating both laryngeal and extralaryngeal findings associated with LPR. The RSA demonstrated high intra- and interrater reliabilities and responsiveness to change.
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- 2019
57. Are the Acoustic Measurements Reliable in the Assessment of Voice Quality? A Methodological Prospective Study
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Sven Saussez, Myriam Piccaluga, Bernard Harmegnies, Véronique Delvaux, Serge Blecic, Jerome R. Lechien, Camille Finck, and Kathy Huet
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medicine.medical_specialty ,Voice Quality ,Audiology ,Physical strength ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Laryngopharyngeal reflux ,0302 clinical medicine ,Vowel ,medicine ,Laryngopharyngeal Reflux ,Humans ,Reflux symptom ,Prospective Studies ,030223 otorhinolaryngology ,Prospective cohort study ,Pantoprazole ,business.industry ,Reflux ,Acoustics ,LPN and LVN ,medicine.disease ,Otorhinolaryngology ,Duration (music) ,0305 other medical science ,business ,psychological phenomena and processes ,medicine.drug - Abstract
Summary Objective Acoustic parameters are widely used as voice quality therapeutic outcomes in many laryngological diseases. The aim of this study is to explore the impact of changes in the nature and duration of the analyzed time interval and the vowel choice on the significance of the acoustic measurements used as therapeutic outcomes in two different diseases. Study Design A prospective case series. Material and Methods From September 2013 to January 2018, patients with laryngopharyngeal reflux (LPR) disease were recruited and treated with pantoprazole, diet, and behavioral changes for 3 months. The reflux symptom index and reflux finding score were used for both diagnosis and assessment of treatment effectiveness. Simultaneously, patients with early idiopathic Parkinson's disease (IPD) were enrolled and benefited from a levodopa challenge test. An Iowa Oral Performance Instrument was used for objective outcomes in the assessment of levodopa effectiveness on muscular strength of IPD patients. Acoustic measurements were performed in both groups pre- and postmedication intake at different time intervals, including the “most stable” time intervals of 1 second, 2 seconds, 3 seconds, 4 seconds, and 5 seconds and a 1 second-time interval positioned at mid-production. We also measured acoustic parameters on the entire signal of three vowels and on the signal of each vowel being taken separately. Results A total of 80 LPR and 19 IPD patients met our inclusion criteria and completed the study protocol. LPR and IPD patients had significant clinical improvements throughout treatment, according to reflux symptom index, reflux finding score, and Iowa Oral Performance Instrument scores. The acoustic analysis revealed that acoustic parameters significantly improved from pre- to post-treatment and varied across methods used for measurement. The duration and position of the analyzed time interval in the production and the vowel on which the acoustic measures were made yielded considerable differences in the results. Conclusion Depending on the time interval over which the acoustic parameters are measured, the clinically demonstrated effect of the medication may or may not be statistically demonstrated irrespective of the disease. According to the results of this study and regarding the lack of standardization of acoustic measurement methods, a line of thought is proposed to bypass the interval selection problem.
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- 2019
58. Phonological and phonetic impairment in aphasic speech: an acoustic study of the voice onset time of six French-speaking aphasic patients
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Bernard Harmegnies, Véronique Delvaux, Clémence Verhaegen, Myriam Piccaluga, Sophie Fagniart, and Kathy Huet
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Adult ,Male ,Linguistics and Language ,medicine.medical_specialty ,Speech production ,Audiology ,Neuropsychological Tests ,behavioral disciplines and activities ,Language and Linguistics ,Speech and Hearing ,Speech Production Measurement ,Aphasia ,otorhinolaryngologic diseases ,medicine ,Humans ,Levels-of-processing effect ,Phonological Disorder ,Aged ,Voice-onset time ,Neuropsychology ,Linguistics ,Acoustics ,Middle Aged ,Variety (linguistics) ,Voice ,Female ,France ,medicine.symptom ,Psychology - Abstract
The aim of the present study is to contribute to the description of the speech production deficits in French-speaking aphasic patients, so as to shed light on their potential phonetic and/or phonological disorders. Acoustic studies of aphasics' speech productions remain relatively infrequent, especially in French, and when entering into the specifics, often lead to inconsistent results. We conducted a multiple-case study on six aphasic patients, four with non-fluent aphasia and two with fluent aphasia. They were administered a variety of language and neuropsychological tasks, then they participated in a customized non-word repetition task. Acoustic analyses of their speech productions were performed, focussing on VOT as the main acoustic correlate of the voicing contrast for oral stops. Other atypicalities in their productions were also classified. Results showed variable and mainly "mixed" phonetic-phonological impairment profiles that differed from the traditional hypotheses made in the literature about the speech deficits to be expected as a function of type of aphasia. Our results support the use of acoustic analyses in order to complete language examination in aphasic patients but also suggest that the frontier between phonological and phonetic impairment is not clear-cut. These outcomes are better accounted for by theories and models postulating close relationships between the phonological and phonetic levels of processing.
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- 2019
59. Cover Image
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Jérôme R. Lechien, Kathy Huet, Mohamad Khalife, Lisa G. De Marrez, Camille Finck, Bernard Harmegnies, and Sven Saussez
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Otorhinolaryngology - Published
- 2019
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60. Validity and reliability of the reflux symptom score
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Giovanni Dapri, Mihaela Horoi, Vinciane Muls, Alexandra Rodriguez Ruiz, Marie‐Therese Maréchal, Didier Dequanter, Francois Bobin, Kathy Huet, Sven Saussez, Camille Finck, Bernard Harmegnies, Katharina Ostermann, Marie Paule Thill, and Jerome R. Lechien
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Adult ,Male ,medicine.medical_specialty ,RSS ,Validity ,Severity of Illness Index ,Asymptomatic ,External validity ,Young Adult ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Cronbach's alpha ,Surveys and Questionnaires ,Internal medicine ,Laryngopharyngeal Reflux ,medicine ,Humans ,Translations ,Patient Reported Outcome Measures ,Prospective Studies ,Internal validity ,030223 otorhinolaryngology ,Aged ,Pantoprazole ,Aged, 80 and over ,business.industry ,Reproducibility of Results ,computer.file_format ,Middle Aged ,medicine.disease ,ROC Curve ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Female ,Symptom Assessment ,medicine.symptom ,business ,computer ,medicine.drug - Abstract
Objectives/hypothesis To develop and validate the Reflux Symptom Score (RSS), a self-administered patient-reported outcome questionnaire for patients with laryngopharyngeal reflux (LPR). Study design Prospective controlled study. Methods A total of 113 patients with LPR were enrolled and treated with diet and 3 months of pantoprazole, alginate, and/or magaldrate depending on the LPR characteristics (acid, nonacid, or mixed). Eighty asymptomatic individuals completed the study. Patients and controls completed the RSS twice within a 7-day period to assess test-retest reliability. Internal consistency was measured using Cronbach's α for the RSS items in patients and controls. Validity was assessed by comparing the baseline RSS with the Reflux Symptom Index (RSI) and Voice Handicap Index (VHI). Seventy-seven patients completed the RSS at baseline and after 6 and 12 weeks of treatment to assess responsiveness to change. The RSS cutoff for determining the presence and absence of LPR was examined by receiver operating characteristic analysis. Results Test-retest reliability (rs = 0.921) and internal consistency reliability (α = 0.969) were high. RSS exhibited high external validity indicated by a significant correlation with the RSI (rs = 0.831). Internal validity was excellent based on the higher RSS in patients compared with controls (P = .001). RSS, RSI, and VHI scores significantly improved from pre- to posttreatment, indicating a high responsiveness to change. RSS >13 can be considered suggestive of LPR-related symptoms. RSS was not influenced by the occurrence of gastroesophageal reflux disease, LPR subtypes, or patient characteristics. Conclusions RSS is a self-administered patient-reported outcome questionnaire that demonstrates high reliability and excellent criterion-based validity. RSS can be used in diagnosing and monitoring LPR disease. Level of evidence 3b Laryngoscope, 130:E98-E107, 2020.
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- 2019
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61. Perceptual, Aerodynamic, and Acoustic Characteristics of Voice Changes in Patients with Laryngopharyngeal Reflux Disease
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Myriam Piccaluga, Véronique Delvaux, Laura Bousard, Sven Saussez, Mohamad Khalife, Bernard Harmegnies, Camille Finck, Jerome R. Lechien, and Kathy Huet
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Voice Quality ,media_common.quotation_subject ,Disease ,Laryngitis ,Vocal Cords ,Audiology ,Correlation ,03 medical and health sciences ,Laryngopharyngeal reflux ,Young Adult ,0302 clinical medicine ,Perception ,otorhinolaryngologic diseases ,medicine ,Laryngopharyngeal Reflux ,Edema ,Humans ,In patient ,Voice Handicap Index ,Stroboscopy ,030223 otorhinolaryngology ,media_common ,Aged ,Aged, 80 and over ,Voice Disorders ,Laryngoscopy ,business.industry ,Reflux ,Middle Aged ,medicine.disease ,Dysphonia ,Otorhinolaryngology ,Spirometry ,030220 oncology & carcinogenesis ,Case-Control Studies ,Granulation Tissue ,Female ,business - Abstract
Laryngopharyngeal reflux (LPR) is an inflammatory condition suspected to be associated with dysphonia. In this study, we investigated multidimensional perceptual, aerodynamic, and acoustic voice changes in patients with clinically diagnosed LPR compared to healthy participants. We prospectively included 80 outpatients with Reflux Finding Score (RFS) >7 and Reflux Symptom Index (RSI) >13 from September 2013 to April 2016 and we compared clinical and voice quality assessments of these patients with 80 healthy participants. Statistically significant differences were found between groups with regard to Voice Handicap Index, perceptual voice quality (grades of dysphonia, roughness, strain, breathiness, asthenia, and instability), phonatory quotient, percentage jitter, percentage shimmer, peak-to-peak amplitude variation, standard deviation of fundamental frequency, and noise to harmonic ratio. Granulation score of RFS was found to affect the highest number of acoustic parameters. We did not identify significant correlation between vocal fold edema and objective voice quality measurements. This study supports that patients with LPR have significant deterioration of both subjective and objective voice quality compared to healthy participants.
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- 2019
62. Voice outcomes of laryngopharyngeal reflux treatment: a systematic review of 1483 patients
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Kathy Huet, Jerome R. Lechien, Bernard Harmegnies, Camille Finck, Pedro Costa de Araujo, Sven Saussez, Véronique Delvaux, and Myriam Piccaluga
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medicine.medical_specialty ,Voice Quality ,Disease ,Laryngitis ,Audiology ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Laryngopharyngeal Reflux ,medicine ,Humans ,Clinical significance ,Disease management (health) ,030223 otorhinolaryngology ,Voice Disorders ,business.industry ,Disease Management ,General Medicine ,medicine.disease ,Systematic review ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Voice ,Physical therapy ,Neurosurgery ,business - Abstract
The aim of this study is to explore voice quality modifications in laryngopharyngeal reflux (LPR) disease and to understand better the pathophysiological mechanisms underlying the development of communicative disability. Biological Abstracts, BioMed Central, Cochrane database, PubMed and Scopus were assessed for subject headings using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations. Relevant studies published between January 1990 and December 2015 describing the evaluation of voice quality in LPR disease were retrieved. Issues of clinical relevance, such as LPR diagnosis method, treatment efficacy and outcomes, were evaluated for each study. We determined the grade of recommendation for each publication according to the Oxford Centre for Evidence-Based Medicine evidence levels. The search identified 145 publications, of which 25 studies met the inclusion criteria for a total of 1483 LPR patients. Data were extracted by 2 independent physicians who identified 16 trials with a IIb evidence level, 7 trials with a IIa evidence level and 2 RCTs with a Ib evidence level where 4 patient-based instruments and 5 clinician-based instruments were used. The main voice assessment outcomes reported were hoarseness assessments by physicians or patients, followed by acoustic parameters; 15 and 14 articles, respectively, demonstrated significant improvements in subjective and objective voice assessments after treatment. The methodology used to measure acoustic parameters (i.e. sustained vowel duration, the sample portion choice for measurement, etc.) varied from one study to another. The majority of studies indicated that voice quality assessments (especially acoustic parameters) remain an interesting outcome to measure the effectiveness of treatment, but further studies using standardised and transparent methodology to measure acoustic parameters are necessary to confirm the place of each tool in the LPR disease evaluation.
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- 2016
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63. Association between laryngopharyngeal reflux and benign vocal folds lesions: A systematic review
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Maria Rosaria Barillari, Serge-Daniel Le Bon, Lise Crevier-Buchman, Jerome R. Lechien, Andrea Nacci, Camille Finck, Bernard Harmegnies, Lee M. Akst, Alexandra Rodriguez, Sven Saussez, Lechien, J. R., Saussez, S., Nacci, A., Barillari, M. R., Rodriguez, A., Le Bon, S. D., Crevier-Buchman, L., Harmegnies, B., Finck, C., Akst, L. M., University of Mons [Belgium] (UMONS), and Laboratory of Anatomy
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medicine.medical_specialty ,nodule ,Basic science ,vocal fold ,Reflux ,Vocal Cords ,Cochrane Library ,Laryngeal Diseases ,lesion ,03 medical and health sciences ,Laryngopharyngeal reflux ,Polyps ,0302 clinical medicine ,Reinke's edema ,Edema ,Laryngopharyngeal Reflux ,medicine ,Humans ,Prospective Studies ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics ,030223 otorhinolaryngology ,ComputingMilieux_MISCELLANEOUS ,Retrospective Studies ,cyst ,Clinical Trials as Topic ,business.industry ,sulcu ,Laryngeal Edema ,medicine.disease ,Dermatology ,laryngopharyngeal ,Systematic review ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Vocal folds ,polyp ,medicine.symptom ,benign ,business ,vocal cord - Abstract
Objectives To investigate the role of laryngopharyngeal reflux (LPR) in the development of benign lesions of the vocal folds (BLVF). Methods PubMed, Cochrane Library, and Scopus were searched by three independent investigators for articles published between January 1990 and November 2018 providing substantial information about the role of LPR in the development of nodules, polyps, cysts, Reinke's edema, and sulcus vocalis. Inclusion, exclusion, diagnostic criteria and clinical outcome evaluation of included studies were analyzed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Results Of the 155 relevant publications, 42 studies were included. Thirty-five were clinical studies and seven were experimental research studying the impact of reflux on vocal fold tissue. Only seven clinical studies utilized objective LPR diagnoses (pH monitoring), suggesting an association between LPR and the development of nodules, polyps, and Reinke's edema. These studies were characterized by a substantial heterogeneity due to discrepancies in inclusion/exclusion criteria, diagnostic methods, and clinical outcome evaluation. The few basic science studies on this topic support that LPR creates an environment that may predispose to BLVF through changes in defense mechanisms of the vocal folds, cell-to-cell dehiscence, inflammatory reaction of the vocal folds, and reaction to phonotrauma. Conclusions Caustic mucosal injury from LPR could cause increased susceptibility of the vocal fold mucosa to injury and subsequent formation of nodules, polyps, or Reinke's edema. However, the heterogeneity and the low number of high-quality studies limit the ability to draw definitive conclusions. Future clinical and experimental studies are needed to better identify the role of reflux in development of BLVF. Laryngoscope, 129:E329-E341, 2019.
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- 2019
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64. Laryngopharyngeal Reflux as Causative Factor of Vocal Fold Nodules
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Bernard Harmegnies, Sven Saussez, Camille Finck, and Jerome R. Lechien
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medicine.medical_specialty ,Fold (higher-order function) ,business.industry ,Vocal Cords ,LPN and LVN ,medicine.disease ,Gastroenterology ,Pepsin A ,Laryngeal Diseases ,Speech and Hearing ,Laryngopharyngeal reflux ,Polyps ,Otorhinolaryngology ,Internal medicine ,Laryngopharyngeal Reflux ,medicine ,Humans ,business - Published
- 2020
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65. Towards a Better Characterization of Parkinsonian Speech: A Multidimensional Acoustic Study
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Kathy Huet, Myriam Piccaluga, Véronique Delvaux, Sophie van Malderen, and Bernard Harmegnies
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Computer science ,Speech recognition ,Characterization (materials science) - Published
- 2018
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66. Alkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: Our experience on 65 patients
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Sven Saussez, Lisa G. De Marrez, Bernard Harmegnies, Jerome R. Lechien, Camille Finck, Mohamad Khalife, and Kathy Huet
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Male ,medicine.medical_specialty ,Esophageal pH Monitoring ,Voice Quality ,MEDLINE ,Disease ,Gastroenterology ,Laryngopharyngeal reflux ,Belgium ,Internal medicine ,Diet, Protein-Restricted ,Laryngopharyngeal Reflux ,Medicine ,Humans ,Diet, Fat-Restricted ,Life Style ,Pantoprazole ,Retrospective Studies ,Acid-Base Equilibrium ,medicine.diagnostic_test ,business.industry ,Life style ,Retrospective cohort study ,Proton Pump Inhibitors ,Middle Aged ,medicine.disease ,Otorhinolaryngology ,Multicenter study ,Female ,business ,Esophageal pH monitoring - Published
- 2018
67. Voice Quality as Therapeutic Outcome in Laryngopharyngeal Reflux Disease: A Prospective Cohort Study
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Jerome R. Lechien, Bernard Harmegnies, Myriam Piccaluga, Kathy Huet, Anne-Françoise Fourneau, Sven Saussez, Camille Finck, Véronique Delvaux, and Mohamad Khalife
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Male ,medicine.medical_specialty ,Time Factors ,Voice Quality ,Laryngitis ,Audiology ,Speech Acoustics ,Correlation ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Laryngopharyngeal reflux ,0302 clinical medicine ,Phonation ,Speech Production Measurement ,Laryngopharyngeal Reflux ,Medicine ,Humans ,Prospective Studies ,Voice Handicap Index ,030223 otorhinolaryngology ,Prospective cohort study ,Pantoprazole ,Voice Disorders ,business.industry ,Reflux ,Proton Pump Inhibitors ,Acoustics ,Recovery of Function ,Middle Aged ,LPN and LVN ,medicine.disease ,medicine.anatomical_structure ,Treatment Outcome ,Otorhinolaryngology ,Vocal folds ,Quality of Life ,Female ,Diet, Healthy ,0305 other medical science ,business ,Risk Reduction Behavior ,medicine.drug - Abstract
Summary Purpose To study the usefulness of voice quality as therapeutic outcome in laryngopharyngeal reflux disease. Material and methods A total of 80 patients with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were treated with pantoprazole, diet, and lifestyle recommendations for 3 months. The therapeutic effectiveness was assessed with RSI; RFS; Voice Handicap Index; blinded Grade, Roughness, Breathiness, Asthenia, Strain, and Instability (GRBASI); aerodynamic and a panel of acoustic measurements before and after treatment. A correlation analysis between symptoms, videolaryngostroboscopic signs, and acoustic measurements was conducted. Results Compared to baseline, means of RSI, RFS, Voice Handicap Index, perceptual dysphonia, and roughness significantly decreased. Significant improvements of phonatory quotient, percent jitter, percent shimmer, Relative Average Perturbation, Pitch Perturbation Quotient, Phonatory F0 Range, Amplitude Perturbation Quotient, smooth Amplitude Perturbation Quotient, and Peak-to-Peak Amplitude Variation were found at the end of treatment. Studies of correlation did not identify relevant correlation between videolaryngostroboscopic signs, especially vocal folds edema, and objective voice quality evaluations. Conclusion Voice quality assessments can help to better understand voice disorders and can be used as indicators of the treatment effectiveness in patients with laryngopharyngeal reflux-related symptoms.
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- 2018
68. Clinical outcomes of laryngopharyngeal reflux treatment: A systematic review and meta-analysis
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Fabrice Journe, Bernard Harmegnies, Marianne Paesmans, Lisa G. De Marrez, Petros D. Karkos, Antonio Schindler, Michael F. Vaezi, Abdul-Latif Hamdan, Sven Saussez, Jerome R. Lechien, and Camille Finck
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medicine.medical_specialty ,Placebo ,law.invention ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Randomized controlled trial ,law ,Epidemiology ,medicine ,Laryngopharyngeal Reflux ,Humans ,030223 otorhinolaryngology ,Intensive care medicine ,Randomized Controlled Trials as Topic ,business.industry ,Proton Pump Inhibitors ,medicine.disease ,Clinical trial ,Systematic review ,Treatment Outcome ,Otorhinolaryngology ,Meta-analysis ,Relative risk ,030211 gastroenterology & hepatology ,business - Abstract
Objectives To investigate the therapeutic benefit of proton pump inhibitors (PPIs) over placebo in patients with laryngopharyngeal reflux (LPR) and to analyze the epidemiological factors of heterogeneity in the literature. Methods An electronic literature search was conducted to identify articles published between 1990 and 2018 about clinical trials describing the efficiency of medical treatment(s) on LPR. First, a meta-analysis of placebo randomized controlled trials (RCTs) comparing PPIs versus placebo was conducted according to diet. The heterogeneity, response to PPIs, and evolution of clinical scores were analyzed for aggregate results. Second, a systematic review of diagnosis methods, clinical outcome of treatment, and therapeutic regimens was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results The search identified 1,140 relevant publications, of which 72 studies met the inclusion criteria for a total of 5,781 patients. Ten RCTs were included in the meta-analysis. The combined relative risk was 1.31 in favor of PPIs and increased to 1.42 when patients did not receive diet recommendations. Randomized controlled trials were characterized by a significant heterogeneity due to discrepancies in clinical therapeutic outcomes, diagnosis methods (lack of gold standard diagnostic tools), and therapeutic scheme. The epidemiological analysis of all articles supports the existence of these discrepancies in the entire literature. In particular, many symptoms and signs commonly encountered in LPR are not assessed in the treatment effectiveness. The lack of diagnosis precision and variability of inclusion criteria particularly create bias in all reported and included articles. Conclusion This meta-analysis supports a mild superiority of PPIs over placebo and the importance of diet as additional treatment but demonstrates the heterogeneity between studies, limiting the elaboration of clear conclusions. International recommendations are proposed for the development of future trials. Laryngoscope, 129:1174-1187, 2019.
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- 2018
69. Étude exploratoire des stratégies de production du ton 3 en chinois mandarin
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Kathy Huet, Véronique Delvaux, Bernard Harmegnies, Guoxian Zhang, Myriam Piccaluga, and Yizhi Huang
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- 2018
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70. Un protocole de recueil de productions orales chez l'enfant préscolaire : une étude préliminaire auprès d'enfants bilingues
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Bernard Harmegnies, Kathy Huet, Véronique Delvaux, Myriam Piccaluga, Morgane Monnier, and Marie Philippart De Foy
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- 2018
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71. La distinction entre les paraphasies phonologiques et phonétiques dans l'aphasie : Étude acoustique des productions de 6 patients aphasiques
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Myriam Piccaluga, Véronique Delvaux, Clémence Verhaegen, Sophie Fagniart, Bernard Harmegnies, and Kathy Huet
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- 2018
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72. The development of new clinical instruments in laryngopharyngeal reflux disease: The international project of young otolaryngologists of the International Federation of Oto-rhino-laryngological Societies
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Jerome R. Lechien, Lise Crevier-Buchman, Maria Rosaria Barillari, Camille Finck, Sven Saussez, Francois Bobin, Didier Dequanter, Antonio Schindler, Abdul-Latif Hamdan, E. Bartaire, Petros D. Karkos, Tareck Ayad, Bernard Harmegnies, Alexandra Rodriguez, Lechien Jerome, R, Schindler, Antonio, Hamdan, Al, Bobin, F, Barillari, Maria Rosaria, Harmegnies, B, Dequanter, D, Rodriguez, A, Bartaire, E, Ayad, T, Karkos, P, Crevier-Buchman, L, Finck, C, and Saussez, S
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medicine.medical_specialty ,Pediatrics ,Laryngopharyngeal ,Reflux ,Context (language use) ,Disease ,Laryngitis ,Placebo ,Severity of Illness Index ,law.invention ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Randomized controlled trial ,law ,Laryngiti ,Epidemiology ,medicine ,Laryngopharyngeal Reflux ,Humans ,030223 otorhinolaryngology ,Societies, Medical ,Randomized Controlled Trials as Topic ,business.industry ,medicine.disease ,Treatment ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Inclusion and exclusion criteria ,Surgery ,business - Abstract
Introduction To analyze the epidemiological characteristics of placebo controlled randomized trials (RCTs) that evaluated the effectiveness of medical treatments over placebo in laryngopharyngeal reflux (LPR). Material and methods PubMed, Cochrane database, and Scopus were assessed for subject headings using the PRISMA recommendations. Placebo RCTs published between 1990 and 2018 describing clinical evolution throughout LPR treatment were extracted and analyzed for evidence-based level, number of patients, inclusion and exclusion criteria, gender, age, symptoms and signs used as therapeutic outcomes, and treatment schemes. Results The database search identified 15 placebo RCTs with a total of 763 patients. The mean age of patients was 48.59 years and 52.68% of patients were female. Among the 15 placebo RCTs, 9 have demonstrated a partial or total superiority of a medical treatment over placebo. Most of authors based the LPR diagnosis on symptoms and signs without additional examination. Our analysis reveals an important heterogeneity between studies with regard to the diagnosis criteria, treatment schemes and signs and symptoms used as therapeutic outcomes. Many commonly reported signs and symptoms related to LPR were not used as therapeutic outcomes. Half of the authors did not prescribe diet and behavioral changes along the treatment. Conclusion The controversy in the RCTs about the superiority of medical treatment over placebo in LPR disease is probably due to discrepancies in the diagnosis method, exclusion criteria, therapeutic schemes and the lack of comprehensive tools for the assessment of signs and symptoms. In this context, the LPR Study Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies developed two new instruments to precisely assess signs and symptoms throughout the treatment. These two instruments could be used in future trials comparing medical treatment over placebo in LPR disease.
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- 2018
73. In response to Double-blind, placebo-controlled study with alginate suspension for laryngopharyngeal reflux disease
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Jerome R, Lechien, Petros D, Karkos, Bernard, Harmegnies, and Sven, Saussez
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Treatment Outcome ,Double-Blind Method ,Alginates ,Laryngopharyngeal Reflux ,Humans - Published
- 2018
74. Voice quality outcomes of idiopathic Parkinson's disease medical treatment: A systematic review
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Bernard Harmegnies, Véronique Delvaux, Sven Saussez, Kathy Huet, Virginie Roland, Serge Blecic, Jerome R. Lechien, and Myriam Piccaluga
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medicine.medical_specialty ,Voice Disorders ,Medical treatment ,business.industry ,Voice Quality ,media_common.quotation_subject ,Healthy subjects ,Parkinson Disease ,Disease ,Controlled studies ,Idiopathic parkinson's disease ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,Physical therapy ,medicine ,Humans ,Quality (business) ,Clinical significance ,030223 otorhinolaryngology ,Database research ,business ,030217 neurology & neurosurgery ,media_common - Abstract
Introduction To investigate voice quality (VQ) impairments in idiopathic Parkinson's disease (IPD) and to explore the impact of medical treatments and L-Dopa challenge testing on voice. Methods Relevant studies published between January 1980 and June 2017 describing VQ evaluations in IPD were retrieved using PubMed, Scopus, Biological Abstracts, BioMed Central and Cochrane databases. Issues of clinical relevance, including IPD treatment efficiency and voice quality outcomes, were evaluated for each study. The grade of recommendation for each publication was determined according to the Oxford Centre for Evidence-Based Medicine evidence levels. Results The database research yielded 106 relevant publications, of which 33 studies met the inclusion criteria, for a total of 964 patients with IPD. Data were extracted by 3 independent physicians who identified 21, 11 and 1 trials with IIIb, IIb and IIa evidence levels, respectively. The main VQ assessment tools used were acoustic testing (N = 27), aerodynamic testing (N = 10), subjective measurements (N = 8) and videolaryngostroboscopy (N = 3). The majority of trials (N = 32/33) identified subjective or objective VQ improvements after medical treatment (N = 10) or better VQ evaluations in healthy subjects compared to patients with IPD (N = 22). Especially, our analysis supports that VQ overall improves during the L-Dopa challenge testing, making the VQ evaluation an additional tool for the IPD diagnosis. The methodology used to assess subjective and objective VQ substantially varied from 1 study to another. All of the included studies took into consideration the patient's clinical profile in the VQ analysis. Conclusion The majority of studies supported that VQ assessments remain useful as outcome measures of the effectiveness of medical treatment and could be helpful for the IPD diagnosis based on L-Dopa challenge testing. Further controlled studies using standardised and transparent methodology for measuring acoustic parameters are necessary to confirm the place of each tool in both IPD diagnosis and treatment evaluation.
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- 2018
75. Image analysis of the interarytenoid area to detect laryngopharyngeal reflux disease
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Sven Saussez, Jerome R. Lechien, and Bernard Harmegnies
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medicine.medical_specialty ,business.industry ,Reflux ,medicine.disease ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Laryngitis ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Laryngopharyngeal Reflux ,Medicine ,Humans ,Radiology ,030223 otorhinolaryngology ,business - Published
- 2017
76. Évolution de l’organisation du système vocalique du français en contexte de bilinguisme simultané
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Myriam Piccaluga, Véronique Delvaux, Bernard Harmegnies, Kathy Huet, Marie Philippart De Foy, and Morgane Monnier
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lcsh:Social Sciences ,lcsh:H ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Political science ,05 social sciences ,0501 psychology and cognitive sciences ,0305 other medical science ,Humanities ,050105 experimental psychology - Abstract
Cette étude vise à examiner le développement phonético-phonologique du français et plus précisément la progressive organisation du système vocalique chez des enfants bilingues préscolaires exposés à l’une des trois combinaisons linguistiques suivantes : français-italien, français-arabe et français-mandarin. Les productions orales des enfants ont été recueillies longitudinalement via une tâche de dénomination originale en français. La dominance linguistique des enfants ainsi que leur développement lexical ont été évalués via des questionnaires parentaux. L’évolution de l’organisation du système vocalique a été évaluée via l’indice PHI (Huet & Harmegnies, 2000) permettant de générer une mesure de dispersion des valeurs formantiques dans l’espace vocalique. L’impact de la combinaison et de la dominance linguistiques ainsi que du développement lexical sur l’organisation du système vocalique a été investigué. Les résultats indiquent : (1) un système vocalique initialement mieux organisé chez les bilingues français-italien, (2) une augmentation parallèle de l’organisation du système vocalique et de la compétence lexicale chez les bilingues français-italien et français-arabe et (3), aucun effet de la dominance linguistique. Ces résultats enrichissent les connaissances sur le développement de la parole en français dans des contextes de bilinguisme simultané contrastés.
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- 2020
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77. In response to Double-blind, placebo-controlled study with alginate suspension for laryngopharyngeal reflux disease
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Bernard Harmegnies, Jerome R. Lechien, Petros D. Karkos, and Sven Saussez
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medicine.medical_specialty ,business.industry ,Treatment outcome ,Placebo-controlled study ,medicine.disease ,Gastroenterology ,Double blind ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030223 otorhinolaryngology ,Suspension (vehicle) ,business - Published
- 2018
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78. Quantitative study of the effects of settings changes on the LTAS.
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Bernard Harmegnies, John H. Esling, and Veronique Delplancq
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- 1989
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79. Effects of language change on voice quality. an experimental contribution to the study of the catalan-castilian case.
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Bernard Harmegnies, Marielle Bruyninckx, Joaquim Llisterri, and Dolors Poch
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- 1989
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80. Laryngopharyngeal Reflux and Voice Disorders: A Multifactorial Model of Etiology and Pathophysiology
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Sven Saussez, Camille Finck, Jerome R. Lechien, James A. Burns, and Bernard Harmegnies
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Pathology ,medicine.medical_specialty ,Voice Quality ,Disease ,Laryngitis ,Vocal Cords ,Cochrane Library ,Vibration ,Speech Acoustics ,03 medical and health sciences ,Speech and Hearing ,Laryngopharyngeal reflux ,0302 clinical medicine ,Phonation ,Risk Factors ,medicine ,Laryngopharyngeal Reflux ,Animals ,Humans ,Stroboscopy ,030223 otorhinolaryngology ,Hoarseness ,Laryngoscopy ,business.industry ,Reflux ,LPN and LVN ,medicine.disease ,Prognosis ,Dermatology ,Pathophysiology ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Vocal folds ,Etiology ,business - Abstract
Summary Objective The aim of this paper is to shed light on the pathogenesis and pathophysiological mechanisms underlying the development of hoarseness related to laryngopharyngeal reflux disease (LPRD). Material and methods PubMed, Embase, and The Cochrane Library were searched for the terms reflux, laryngopharyngeal, laryngitis, voice, and hoarseness. Experimental and clinical studies providing substantial information about the occurrence of voice disorders, laryngeal histologic changes, or any pathophysiological processes related to LPRD were included by two independent investigators. Results Of the 104 studies reviewed, 47 studies that met our inclusion criteria were analyzed. LPRD leads to significant macroscopic and microscopic histopathologic changes in the mucosa of the vibratory margin of the vocal folds. More and more studies suspect that epithelial cell dehiscence, microtraumas, inflammatory infiltrates, Reinke space dryness, mucosal drying, and epithelial thickening are probably responsible for the hoarseness related to reflux and the impairment of the subjective and objective voice quality evaluations. Conclusion Future clinical studies examining the pathophysiology of hoarseness related to LPRD should take into consideration all potential mechanisms involved in the development of hoarseness.
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- 2017
81. Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study
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Bernard Harmegnies, Mohamad Khalife, Sven Saussez, Jerome R. Lechien, Myriam Piccaluga, Véronique Delvaux, Anne Françoise Fourneau, and Kathy Huet
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Adult ,Male ,medicine.medical_specialty ,Laryngology ,Voice Quality ,Laryngopharyngeal reflux ,Audiology ,2-Pyridinylmethylsulfinylbenzimidazoles ,Voice Disorder ,03 medical and health sciences ,0302 clinical medicine ,Subjective and objective assessment ,otorhinolaryngologic diseases ,Humans ,Medicine ,Original Research Article ,Prospective Studies ,Voice Handicap Index ,030223 otorhinolaryngology ,Prospective cohort study ,Pantoprazole ,Aged ,Voice Disorders ,Laryngoscopy ,business.industry ,Reflux ,Proton Pump Inhibitors ,Middle Aged ,medicine.disease ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Reflux laryngitis ,Voice ,Female ,Surgery ,business ,medicine.drug - Abstract
Background Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. Methods Forty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months. RSI, RFS, Voice Handicap Index (VHI), and Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) were assessed at baseline and after three months post-therapy. Acoustic parameters were measured by selecting the most stable interval of the vowel /a/. A study of correlations between acoustic measurements and laryngoscopic signs was conducted in patients with roughness. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS). Results Significant improvement in RSI, RFS, VHI, jitter, percent jitter, relative average perturbation (RAP), shimmer, percent shimmer, and amplitude perturbation quotient (APQ) was found at 3 months of treatment (p
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- 2016
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82. The Production of Intervocalic Glides in Non Dysarthric Parkinsonian Speech
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Myriam Piccaluga, Kathy Huet, Marie-Claire Haelewyck, Véronique Delvaux, Bernard Harmegnies, and Virginie Roland
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03 medical and health sciences ,0302 clinical medicine ,Computer science ,Speech recognition ,05 social sciences ,Production (economics) ,0501 psychology and cognitive sciences ,030217 neurology & neurosurgery ,050105 experimental psychology - Published
- 2016
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83. Reply to the letter 'Laryngopharyngeal reflux disease in the elderly'
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Sven Saussez, Jerome R. Lechien, and Bernard Harmegnies
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medicine.medical_specialty ,business.industry ,General surgery ,MEDLINE ,General Medicine ,Disease ,medicine.disease ,Hypopharynx ,03 medical and health sciences ,Laryngopharyngeal reflux ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Gastroesophageal Reflux ,Laryngopharyngeal Reflux ,Head and neck surgery ,Humans ,Medicine ,Neurosurgery ,030223 otorhinolaryngology ,business ,Aged - Published
- 2017
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84. Application de la méthode LSVT BIG ® auprès de personnes atteintes de la maladie de Parkinson
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Virginie Roland, A. Schepers, P. Vega, F. Bruyr, and Bernard Harmegnies
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03 medical and health sciences ,0302 clinical medicine ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,030212 general & internal medicine ,030217 neurology & neurosurgery - Abstract
Introduction Les troubles moteurs et non moteurs augmentent au cours de l’evolution de la maladie de Parkinson et se manifestent tant au niveau du corps que de la voix [1] . La methode LSVT BIG ® est un programme protocole, specifique a la prise en charge des patients ayant la maladie de Parkinson et base sur l’amplitude de mouvements [2] . Elle s’inspire de la LSVT LOUD ® , methode de « reeducation sensori-motrice » du discours, pratiquee par les orthophonistes [2] . L’objectif de cette etude est de connaitre les effets de la LSVT BIG ® sur la motricite, l’equilibre, la qualite de vie et la voix. Materiel, population et methode Quatorze patients volontaires atteints de la maladie de Parkinson, de stade I a III selon l’echelle de Hoehn and Yahr, ont beneficie de 16 seances de LSVT BIG ® pendant 4 semaines. Les tests utilises ont ete : le Timed Up and Go (TUG), le Timed Up and Go cognitif (TUG cognitif), le Functional Reach Test (FRT), le Lateral Reach Test (LRT), l’echelle de qualite de vie PDQ-39, le score moteur de l’UPDRS, la stabilometrie et des enregistrements vocaux de logatomes pre-definis. Tous les tests ont ete effectues avant et apres la pratique de la LSVT BIG ® . Pour comparer ces resultats, nous avons utilise le test statistique de Student. Resultats Au niveau physique, des ameliorations significatives ( p 0,05) ont ete observees aux items de gene psychologique, communication, inconfort physique et troubles cognitifs du questionnaire de qualite de vie PDQ-39, au LRT et au centre de gravite dans les plans frontal et sagittal. Au niveau vocal, une amelioration significative aux temps maximaux de phonation a ete observee, d’autant plus importante lors de la tenue d’un « a ». L’amplitude de mouvement des articulateurs supralarynges n’a pas ete modifiee par la pratique de la LSVT BIG ® , mais la localisation des voyelles, dans l’espace vocalique, lors de la prononciation de logatome a ete modifie. Conclusion ou discussion La LSVT BIG ® semble appropriee a la neuroreeducation physique de la maladie de Parkinson. Cette methode, bien acceptee par les patients, demande une formation et un protocole rigoureux que nous avons respecte. Notre etude propose une ouverture vers l’exploration des liens entre la neuroreeducation physique et son influence sur la voix des patients atteints de la maladie de Parkinson.
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- 2017
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85. Implantation of Esterified Hyaluronic Acid in Microdissected Reinke's Space After Vocal Fold Microsurgery: Short- and Long-Term Results
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Philippe Lefebvre, Angélique Remacle, Bernard Harmegnies, and Camille Finck
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Male ,Microsurgery ,medicine.medical_specialty ,Time Factors ,Voice Quality ,medicine.medical_treatment ,Laryngoscopy ,Video Recording ,Vocal Cords ,Surgical Flaps ,Stroboscope ,Laryngeal Diseases ,Speech and Hearing ,chemistry.chemical_compound ,Belgium ,Hyaluronic acid ,Humans ,Medicine ,Prospective Studies ,Hyaluronic Acid ,Stroboscopy ,Prospective cohort study ,Fibrin glue ,Drug Implants ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,Surgical wound ,Recovery of Function ,LPN and LVN ,Combined Modality Therapy ,Anti-Bacterial Agents ,Surgery ,Treatment Outcome ,Otorhinolaryngology ,chemistry ,Female ,Implant ,business ,Microdissection - Abstract
In this study are reported the laryngeal and vocal results obtained after a microflap excision of benign vocal fold (VF) lesions and immediate implantation of esterified hyaluronic acid (EHA) in the surgical wound. In a previous pilot study on 11 cases, we have shown an excellent tolerance of this bioimplant. The objectives are to confirm the innocuity of the technique, to demonstrate the laryngeal and vocal evolution at short and long term, and to evaluate the eventual positive impact of EHA implantation on the pliability of the superficial layer of the lamina propria (SLLP) and on voice. This is a prospective and comparative study on 83 patients suffering from various benign VF lesions. Thirty-three patients were implanted with EHA, whereas 50 patients did not undergo implantation at the end of the microsurgical procedure. All patients undergo rigid laryngoscopy and microflap excision procedure under general anesthesia. After freeing up of the Reinke's space and creation of a mucosal microflap, a few fibers of EHA are inserted in the surgical wound, before closure of the incision with fibrin glue. Serial laryngeal and vocal assessments are performed in all patients using videostroboscopy (Wolff and Xion), perceptual and objective voice evaluation (MDVP software, Kay Elemetrics), and phonatory function measurements (Aerophone II). Pre- and early postoperative means are compared by analysis of variance. Delayed and long-term evolution of laryngeal and vocal data are compared by means of nonparametric statistical methods. The longest follow-up in the implanted group is 4 years. Early postoperative results are similar in both groups: a significant improvement of a majority of laryngeal and vocal data is observed after microsurgery. In the long term, the two groups exhibit a different behavior: further improvement of voice, as an ongoing process, is only observed in the EHA implanted group, together with improvement of some videostroboscopic characteristics. The nonimplanted group remains stable, with no further improvement of the voice quality obtained after microsurgery. Excellent short- and long-term tolerance of EHA implantation is confirmed by this larger series. The use of EHA implant in microdissected SLLP is safe and leads to good laryngeal and vocal outcomes in the treated patients. More interestingly, treated cases exhibit a continuous improvement over a long period of time.
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- 2010
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86. Impact of Chemoradiation After Supra- or Infrahyoid Cancer on Aerodynamic, Subjective, and Objective Voice Assessments: A Multicenter Prospective Study
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Kathy Huet, Mohamad Khalife, Véronique Delvaux, Anne-Françoise Fourneau, Bernard Harmegnies, Jerome R. Lechien, Sven Saussez, and Myriam Piccaluga
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Male ,medicine.medical_specialty ,Voice Quality ,Video Recording ,Audiology ,Speech Acoustics ,Disability Evaluation ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Belgium ,Phonation ,Speech Production Measurement ,Quality of life ,Surveys and Questionnaires ,otorhinolaryngologic diseases ,medicine ,Humans ,In patient ,Prospective Studies ,Stroboscopy ,Voice Handicap Index ,030223 otorhinolaryngology ,Prospective cohort study ,Voice Disorders ,Laryngoscopy ,business.industry ,Head and neck cancer ,Cancer ,Acoustics ,Chemoradiotherapy ,Middle Aged ,LPN and LVN ,medicine.disease ,Otorhinolaryngologic Neoplasms ,Cross-Sectional Studies ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Quality of Life ,Female ,Mouth Neoplasms ,Radiology ,Cranial Irradiation ,business - Abstract
Summary Objectives The study aimed to investigate the impact of chemoradiotherapy (CRT) on speech and voice quality according to the anatomic localization of the head and neck cancer. Methods Thirty-four patients treated by CRT for advanced suprahyoid (N = 17) or infrahyoid (N = 17) cancer were assessed for speech function, videolaryngostroboscopy, Voice Handicap Index, blinded Grade, Roughness, Breathiness, Asthenia, Strain, and Instability, acoustic measurements, and aerodynamic measurements. Quality of life was evaluated using the European Organization for Research and Treatment of Cancer Head and Neck 35 (EORTC QLQ-H&N35) questionnaire. Results Patients treated for an infrahyoid tumor presented more severe values of Voice Handicap Index items, dysphonia, breathiness, asthenia, and some acoustic cues (Voice Turbulence Index, Soft Phonation Index, degree of unvoiced segments, and number of unvoiced segments) than patients treated for a suprahyoid tumor. The EORTC QLQ-H&N35 communication item was better in the suprahyoid patient group. Conclusions Voice quality impairments associated with CRT are more severe in patients treated for advanced infrahyoid cancer, suggesting the need to develop specific posttherapy management of the dysphonia according to the tumor anatomical localization.
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- 2018
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87. Intra-speaker variability of the long term speech spectrum.
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Bernard Harmegnies and Albert Landercy
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- 1988
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88. SDDD: A new dissimilarity index for the comparison of speech spectra.
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Bernard Harmegnies
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- 1988
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89. Validity and Reliability of a French Version of Reflux Symptom Index
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Mohamad Khalife, Jerome R. Lechien, Véronique Delvaux, Anne-Françoise Fourneau, Sven Saussez, Kathy Huet, Camille Finck, Myriam Piccaluga, and Bernard Harmegnies
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Adult ,medicine.medical_specialty ,Validity ,Asymptomatic ,2-Pyridinylmethylsulfinylbenzimidazoles ,Young Adult ,03 medical and health sciences ,Speech and Hearing ,Laryngopharyngeal reflux ,0302 clinical medicine ,Cronbach's alpha ,Laryngopharyngeal Reflux ,medicine ,Humans ,Prospective Studies ,Voice Handicap Index ,030223 otorhinolaryngology ,Prospective cohort study ,Pantoprazole ,Aged ,Aged, 80 and over ,business.industry ,Reflux ,Reproducibility of Results ,Proton Pump Inhibitors ,Middle Aged ,LPN and LVN ,medicine.disease ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Physical therapy ,France ,medicine.symptom ,business ,medicine.drug - Abstract
Summary Objective To develop a French version of the Reflux Symptom Index (Fr-RSI) and to assess its internal consistency, reliability, and clinical validity. Study Design Controlled, prospective trial. Materials and Methods Forty-four patients with a reflux finding score > 7 and an Fr-RSI > 13 were enrolled and treated with 20 mg of pantoprazole twice daily and diet changes for 3 months. Ninety asymptomatic subjects were also included in the study. To assess reliability, Fr-RSI was completed twice within a 7-day period. Validity was assessed by comparing Fr-RSI scores with scores from the Voice Handicap Index (VHI) in 24 of 44 patients, at baseline and at 3 months posttherapy. Results The mean values of Fr-RSI at baseline and after 7 days were 20.17 ± 5.76 and 19.75 ± 7.08, respectively, for patients with laryngopharyngeal reflux (LPR) and 4.02 ± 3.49 and 3.71 ± 3.82, respectively, for controls. The test-retest reliability was high in patients with LPR (r BP = 0.78) and in healthy subjects (r BP = 0.80). Cronbach's alpha was 0.85, indicating high internal consistency. The mean Fr-RSI score significantly improved from a baseline of 20.17 ± 5.76 to 5.58 ± 3.65 after 3 months of treatment ( P = 0.001), and the initial mean VHI total score significantly improved from 20.29 ± 19.62 to 12.87 ± 12.04 after treatment ( P = 0.029), indicating validity of the results. However, of the subcategories of the VHI, only the mean physical score improved from a baseline of 11.19 ± 9.22 to 7.35 ± 5.96 after treatment ( P = 0.016). Conclusion The Fr-RSI developed in this study demonstrated both reliability and validity. It can be easily administered to assist in diagnosing and monitoring of LPR in French-speaking patients.
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- 2017
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90. méthode statistique pour le contrôle des changements vocaliques sous l’effet du style de parole. Applications à l’espagnol
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Bernard Harmegnies, Kathy Huet, and Dolors Poch-Olive
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It is well known that the speech signal conditions of emission can result in influences on the speaker, leading to dramatic changes on her or his speech productions. However, most of the studies performed on the speaking styles restrict their observations on very contrasted situations and compare the so-called spontaneous speech (collected during an ordinary conversation) to the laboratory speech (produced without any communication intention). In this paper, Spanish productions of a single speaker were analysed. Three situations with gradual involvement of the speaker in the communication process have been studied by means of a new methodology for the assessment of the system’s degree of organization in each speaking style, as initiated by previous analysis of Frenchspeaking subjects.
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- 2001
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91. Production training in second language acquisition: a comparison between objective measures and subjective judgments
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Bernard Harmegnies, Véronique Delvaux, Kathy Huet, and Myriam Piccaluga
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Variation (linguistics) ,Computer science ,Speech recognition ,American English ,Similarity (psychology) ,language ,Production (economics) ,French ,behavioral disciplines and activities ,Second-language acquisition ,psychological phenomena and processes ,language.human_language - Abstract
This paper reports on an exploratory study of the processes involved in the acquisition of new phonetic control regimes in L2 learning. We focus here on the acquisition of long VOT initial stops by French native speakers undergoing production training. Francophone speakers were asked to repeat /ta/ stimuli varying in VOT and burst intensity. The performances in production are assessed through a comparison between objective measures performed on the speech signals (VOT, burst intensity) and subjective measures from L2 listeners themselves (in terms of similarity between the model and the response) and from American English native listeners (in terms of similarity as well as L1 typicality). Results show that (i) the Francophone speakers reasonably matched in their responses the VOT and burst intensity variations of the stimuli; (ii) that the three subjective indices are highly correlated with each other, but that they only partially correlate with the acoustic parameters measured on the signals; (iii) that inter-individual variation is very large, among the speakers’productions as well as among the listeners’judgments.
- Published
- 2013
- Full Text
- View/download PDF
92. Time- and spectrum-related variabilities in stressed speech under laboratory and real conditions
- Author
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Dolors Poch, Bernard Harmegnies, Robert Ruiz, Emmanuelle Absil, and Claude Legros
- Subjects
Linguistics and Language ,Computer science ,Communication ,Speech recognition ,Fundamental frequency ,Language and Linguistics ,Computer Science Applications ,Voice analysis ,Formant ,Variation (linguistics) ,Modeling and Simulation ,Vowel ,Histogram ,Stress (linguistics) ,Computer Vision and Pattern Recognition ,Software ,Stroop effect - Abstract
Stress induced by various types of situation leads to vocal signal modifications. Previous studies have indicated that stressed speech is associated with a higher fundamental frequency and noticeable changes in vowel spectrum. This paper presents pitch- and spectral-based analyses of stressed speech corpora drawn from both artificial and real situations. The laboratory corpus is obtained by means of the Stroop test, the real-case corpus is extracted from the Cockpit Voice Recording of a crashed aeroplane. Analyses relative to pitch are presented and an index of microprosodic variation, CL, is introduced. Spectrum-related indicators of stress are issued from a cumulative histogram of sound level and from statistical analyses of formant frequencies. Distances to the F l-F2-F3 centre are also investigated. All these variations, throughout the two different situations, show the direct link between some new vocal parameters and stress appearances. The results confirm the validity of laboratory experiments on stress, but emphazise quantitative as well as qualitative differences between the situations and the speakers involved.
- Published
- 1996
- Full Text
- View/download PDF
93. La qualité palatale
- Author
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Bernard Harmegnies and Marielle Bruyninckx
- Subjects
Linguistics and Language ,Language and Linguistics - Published
- 1996
- Full Text
- View/download PDF
94. Phonetic Approaches of Laryngopharyngeal Reflux Disease: A Prospective Study
- Author
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Mohamad Khalife, Sven Saussez, Véronique Delvaux, Bernard Harmegnies, Anne-Françoise Fourneau, Jerome R. Lechien, Myriam Piccaluga, and Kathy Huet
- Subjects
Male ,Sound Spectrography ,Time Factors ,Audiology ,2-Pyridinylmethylsulfinylbenzimidazoles ,Laryngopharyngeal reflux ,0302 clinical medicine ,Speech Production Measurement ,Prospective Studies ,Young adult ,030223 otorhinolaryngology ,Prospective cohort study ,Pantoprazole ,Hoarseness ,medicine.diagnostic_test ,Middle Aged ,Combined Modality Therapy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Predictive value of tests ,Female ,medicine.drug ,Adult ,medicine.medical_specialty ,Voice Quality ,Laryngoscopy ,Speech Acoustics ,Young Adult ,03 medical and health sciences ,Speech and Hearing ,Phonation ,Phonetics ,Predictive Value of Tests ,Laryngopharyngeal Reflux ,medicine ,Humans ,Aged ,Models, Statistical ,business.industry ,Reflux ,Proton Pump Inhibitors ,Acoustics ,LPN and LVN ,medicine.disease ,Surgery ,Otorhinolaryngology ,business - Abstract
The study aimed to explore the impact of the selection of the analyzed time interval on the significance of acoustic measurements used to investigate laryngopharyngeal reflux (LPR) treatment efficacy, and based on these results to develop an alternative statistical approach in data analysis focusing on individual patient vocal behavior.This is a prospective case series.From September 2013 to July 2015, 41 patients with a reflux finding score (RFS) 7 and a reflux symptom index (RSI) 13 were enrolled and treated with pantoprazole 20 mg twice daily and diet behavioral changes for 3 months. Voice recordings were performed at baseline and after 3 months of treatment. Most stable time intervals of 1, 2, 3, 4, and 5 seconds, and a 1-second time interval positioned at mid-production, were subjected to acoustic analysis. Based on the latter, we developed an "informativeness coefficient" for each acoustic parameter that aimed at assessing its sensitivity to clinical resolution in the case of LPR disease.Significant clinical improvement (RSI and RFS) was observed after treatment (P 0.05). The acoustic analysis revealed that acoustic parameters significantly improving from pre- to posttreatment varied across time intervals. The duration and the position of the analyzed time interval in the production yielded considerable differences in the results. Analysis of the informativeness coefficient indicated that jitter, jitter percent, relative average perturbation (RAP), pitch perturbation quotient (PPQ), shimmer (ShdB), shimmer percent (Shim), amplitude perturbation quotient (APQ), and smoothed amplitude perturbation quotient (sAPQ) were the indices most sensitive to medical treatment efficacy, with a coefficient ranging from 75.86% to 86.21%.Depending on the selection of the time interval over which the acoustic parameters are measured, the potential effect of the treatment may or may not be statistically demonstrated. Future studies are needed to establish standardized methodological procedures for acoustic data analysis.
- Published
- 2017
- Full Text
- View/download PDF
95. Evolution temporelle de la variabilité du spectre moyen à long terme
- Author
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Bernard Harmegnies and Marielle Bruyninckx
- Subjects
030507 speech-language pathology & audiology ,03 medical and health sciences ,[PHYS.HIST]Physics [physics]/Physics archives ,0103 physical sciences ,Cepstrum ,Statistics ,General Physics and Astronomy ,Acoustic spectrum ,0305 other medical science ,010301 acoustics ,01 natural sciences ,Mathematics ,Term (time) - Abstract
Most research concerning the Long Term Average Spectrum (LTAS) variability has consisted in analyses of contemporary vocal utterances but others studies have nevertheless revealed the presence in LTAS of a specific variability depending on time. Purui et al ([1], [21) have shown a good Long Term Cepstrum stability for periods that do not exceed 3 weeks but a significant variability is progressively detected for longer periods. This communication must be inserted in the research work aiming at systematization of all the studies centered on the comparisons of recordings collected at 5-year intervals in similar experimental conditions
- Published
- 1994
- Full Text
- View/download PDF
96. A Phonetic Study of Voice - and Segment - Quality Changes during Second Language Acquisition
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Marielle Bruyninckx and Bernard Harmegnies
- Subjects
Linguistics and Language ,First language ,media_common.quotation_subject ,Sample (statistics) ,Pronunciation ,computer.software_genre ,Second-language acquisition ,Language and Linguistics ,Linguistics ,Term (time) ,Perception ,Quality (business) ,Psychology ,computer ,Interpreter ,media_common - Abstract
In this paper, we study the productions of twelve French-speaking Belgian subjects who attended a first-year Russian course with the aim of becoming translators or interpreters. A perceptual analysis, conducted by experts of Russian pronunciation, enabled us to define each learner's acquisition profile, and led to the choice of three subjects who had the most contrasted acquisition profiles in the sample. Segmental analysis was used in order to capture some specific phonetic processes involved in the acquisition of Russian. A comparison was made with speech samples drawn from the productions of a native speaker of Russian. Using Long Term Average Spectra as acoustic cues to voice quality, we were able to qualify the subjects' productions in a global and measurable way. This quantititative approach confirmed the results of perceptual and segmental analysis.
- Published
- 1994
- Full Text
- View/download PDF
97. Phonetic and/or phonological paraphasias in aphasia: An acoustic study of speech output in two aphasic patients
- Author
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Cl�mence, Verhaegen, primary, V�ronique, Delvaux, additional, Sophie, Fagniart, additional, Kathy, Huet, additional, Myriam, Piccaluga, additional, and Bernard, Harmegnies, additional
- Published
- 2016
- Full Text
- View/download PDF
98. La transparence lexicale en modalité orale; le cas du couple espagnol – français
- Author
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Heidi Siller-Runggaldier, Maria Iliescu, Dolors Poch-Olivé, Myriam Piccaluga, Bernard Harmegnies, and Paul Danler
- Published
- 2010
- Full Text
- View/download PDF
99. Centralización y reducción en las lenguas románicas
- Author
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Dolors Poch and Bernard Harmegnies
- Published
- 2010
- Full Text
- View/download PDF
100. La adaptación del locutor al interlocutor: dinámica del sistema vocálico del español en función de las características de los participantes en la conversación
- Author
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Bernard Harmegnies, Kathy Huet, Dolors Poch Olivé, and C. Dhainaut
- Subjects
Communication ,Lengua española ,business.industry ,media_common.quotation_subject ,First language ,Variación lingüística ,Análisis acústico ,Conversación ,Linguistics ,Variation (linguistics) ,Dynamics (music) ,Vowel ,Reading (process) ,Fonética ,Subject (grammar) ,Mental representation ,Conversation ,Psychology ,business ,Sistema vocálico ,media_common - Abstract
The paper is focused on the hypothesis that the linguistic behaviour of a speaker would depend on how he/she perceives the linguistic status of a person he/she is speaking to. This hypothesis is particularly interesting to study as an index of the mental representation that a determined group has of another, that is to say, the way a speaker adjusts his or her linguistic behaviour to that of the person he or she is speaking to will reflect how the latter is perceived by the speaker being the subject of our study. This paper presents an exploratory study of the dynamics of the Spanish vocalic system under the effect of the linguistic status variations of the interlocutor. A single speaker, native speaker of Spanish, was recorded on 3 situations in which the differences in the status of the person spoken to are clearly marked: a conversation with a native speaker of Spanish, a conversation with a non-native speaker of Spanish, and a reading task of isolated words. The assessment of the system's degree of organization in each speaking style was studied using various indices: the δ index to assess the variation of the degree of centralization of the vowel system under the speaking style variations, the Φ index, which allows better discrimination between the three speaking styles than the discriminant analysis, to quantify the ratio of the inter vocalic class variability compared to the intra vocalic class variability in each speaking style. The results show both that significant inter-style acoustical differences do exist, and that they can better be stressed by the use of the Φ index.
- Published
- 2003
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