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51. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph

Author

Casabonne, D., primary, Reina, O., additional, Benavente, Y., additional, Becker, N., additional, Maynadie, M., additional, Foretova, L., additional, Cocco, P., additional, Gonzalez-Neira, A., additional, Nieters, A., additional, Boffetta, P., additional, Middeldorp, J. M., additional, and de Sanjose, S., additional

Published
2010
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52. Association of JAK-STAT pathway related genes with lymphoma risk

Author

Butterbach, K, primary, Behrens, S, additional, de Sanjosé, S, additional, Benavente, Y, additional, Becker, N, additional, Foretova, L, additional, Maynadie, M, additional, Cocco, P, additional, Staines, A, additional, Boffetta, P, additional, Brennan, P, additional, and Nieters, A, additional

Published
2010
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53. Tumor Necrosis Factor (TNF) and Lymphotoxin- (LTA) Polymorphisms and Risk of Non-Hodgkin Lymphoma in the InterLymph Consortium

Author

Skibola, C. F., primary, Bracci, P. M., additional, Nieters, A., additional, Brooks-Wilson, A., additional, de Sanjose, S., additional, Hughes, A. M., additional, Cerhan, J. R., additional, Skibola, D. R., additional, Purdue, M., additional, Kane, E., additional, Lan, Q., additional, Foretova, L., additional, Schenk, M., additional, Spinelli, J. J., additional, Slager, S. L., additional, De Roos, A. J., additional, Smith, M. T., additional, Roman, E., additional, Cozen, W., additional, Boffetta, P., additional, Kricker, A., additional, Zheng, T., additional, Lightfoot, T., additional, Cocco, P., additional, Benavente, Y., additional, Zhang, Y., additional, Hartge, P., additional, Linet, M. S., additional, Becker, N., additional, Brennan, P., additional, Zhang, L., additional, Armstrong, B., additional, Smith, A., additional, Shiao, R., additional, Novak, A. J., additional, Maynadie, M., additional, Chanock, S. J., additional, Staines, A., additional, Holford, T. R., additional, Holly, E. A., additional, Rothman, N., additional, and Wang, S. S., additional

Published
2010
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54. Personal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma

Author

Zhang, Y., primary, Sanjose, S. D., additional, Bracci, P. M., additional, Morton, L. M., additional, Wang, R., additional, Brennan, P., additional, Hartge, P., additional, Boffetta, P., additional, Becker, N., additional, Maynadie, M., additional, Foretova, L., additional, Cocco, P., additional, Staines, A., additional, Holford, T., additional, Holly, E. A., additional, Nieters, A., additional, Benavente, Y., additional, Bernstein, L., additional, Zahm, S. H., additional, and Zheng, T., additional

Published
2008
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60. Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.

Author

Urayama KY, Jarrett RF, Hjalgrim H, Diepstra A, Kamatani Y, Chabrier A, Gaborieau V, Boland A, Nieters A, Becker N, Foretova L, Benavente Y, Maynadié M, Staines A, Shield L, Lake A, Montgomery D, Taylor M, Smedby KE, and Amini RM

Abstract

Background: Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification.Methods: We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided.Results: Two novel loci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P = 1.3 × 10(-13)) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 × 10(-25)) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 × 10(-15); rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 × 10(-10)) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 × 10(-31)). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study (OR = 1.21, 95% CI = 1.10 to 1.33, P = 1.5 × 10(-4)) and replication series (P = .03).Conclusion: Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. [ABSTRACT FROM AUTHOR]

Published
2012
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61. Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control study.

Author

Costas L, Casabonne D, Benavente Y, Becker N, Boffetta P, Brennan P, Cocco P, Foretova L, Maynadié M, Staines A, Kane E, Nieters A, and de Sanjosé S

Abstract

Background: The study of lymphomagenesis has rarely focused on hormonal factors. Higher incidence rates are observed for many lymphoma subtypes in men compared with women suggesting an underlying association. Our goal was to investigate the association between reproductive factors and lymphomas. Methods: The Epilymph study is a multicenter case-control study carried out in six European countries from 1998 to 2004. Female cases of mature T-cell neoplasms ( n = 52), Hodgkin lymphoma ( n = 147), and mature B-cell neoplasms ( n = 795), including its common subtypes, and their respective controls ( n = 1,141) frequency matched by age, gender, and center were considered. Results: An odds reduction of 29% (95% CI −46 to −6%) was observed for mature T-cell neoplasms for each child increase among parous women and of 13% (95% CI −19 to −7%) for mature B-cell neoplasms; while no association was observed for Hodgkin lymphoma. By B-cell neoplasm subtypes, these associations were found for chronic lymphocytic leukemia/small lymphocytic lymphoma (−21%, 95% CI −31 to −9%) and diffuse large B-cell lymphoma (DLBCL; −14%; 95% CI −23 to −3%). Overall, no associations were observed with age at first and last pregnancy, and ever use of hormonal contraceptives and lymphoma. Higher odds ratios for a short-term use of hormonal contraceptives (<5 years), but not for a long-term use, were observed for mature B-cell neoplasms, DLBCL, and follicular lymphoma compared with never use. Conclusion: These data support the hypothesis that increased parity confers a protective effect against lymphoma. Less clearly, our results also indicate that hormonal contraceptives could play a role. [ABSTRACT FROM AUTHOR]

Published
2012
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62. Nota remitida por D. Antonio Benavente y Montalvo, del Colegio de San Buenaventura de Rioseco, notificando el envío del importe de los derechos de título de socio corresponsal

Author

Benavente y Montalvo, Antonio and Colegio de San Buenaventura. Rioseco (Valladolid)

Subjects
Socios: Nombramientos y Correspondencia
Abstract

Nota remitida por D. Antonio Benavente y Montalvo, del Colegio de San Buenaventura de Rioseco, notificando el envío del importe de los derechos de título de socio corresponsal.

Published
1885

63. Advertencias para Reyes, Principes, y Embaxadores

Author

Benavente y Benavides, Cristobal de, Martínez, Francisco, imp., and Noort, Juan de

Subjects
Educación de príncipes -- España -- Historia -- Siglo 17o, Derecho, España -- Política y gobierno -- Siglo 17o. -- Obras anteriores a 1800
Abstract

Tít. tomado del epígrafe Colofón Sign.: [ ]\p2\s, [calderón]\p4\s, A-Z\p8\s, 2A-2Z\p8\s Texto con doble fileteado Port. grab. calc.: "Juan Noort fecit" La h. de grab. calc.: "Juan de Noort fecit", retr. del priÌ ncipe Baltasar Carlos, en [ ]\b2\s

Published
1642

65. Papeles varios de los reinados de Felipe III y Felipe IV [Manuscrito]

Author

Losada y Prada, Andrés de, Isabel Clara Eugenia, Infanta de España 1566-1633, Felipe IV, Rey de España, Montesclaros, Juan de Mendoza y Luna, Marqués de, Benavente y Benavides, Cristóbal de, Puente, Luis de la 1554-1624, María de Jesús de Ágreda 1602-1665, Benavente Quiñones, Jerónimo de fl. 1655-1661, Mazarin, Jules 1602-1661, Anaya Villanueva, Bartolomé de, Oquendo, Antonio de 1577-1640, Ciudad Real, Juan Alonso Idiáquez de Butrón y Múgica, Duque de m. 1653, Losada y Prada, Andrés de, Isabel Clara Eugenia, Infanta de España 1566-1633, Felipe IV, Rey de España, Montesclaros, Juan de Mendoza y Luna, Marqués de, Benavente y Benavides, Cristóbal de, Puente, Luis de la 1554-1624, María de Jesús de Ágreda 1602-1665, Benavente Quiñones, Jerónimo de fl. 1655-1661, Mazarin, Jules 1602-1661, Anaya Villanueva, Bartolomé de, Oquendo, Antonio de 1577-1640, and Ciudad Real, Juan Alonso Idiáquez de Butrón y Múgica, Duque de m. 1653

Abstract

Manuscritos e impresos, Originales y copias, Carta de Don Andrés de Losada al Marqués de Montes-Claros dándole noticias de la Infanta Doña Isabel (h. 1-2). Carta de la Infanta Doña Isabel a Felipe IV, 1625 (h. 3). Provisiones de Flandes de 1625 (h. 4). Carta del Marqués de Montes-Claros (h. 5). Partidas de 1625 (h. 6). Carta de Felipe a la Infanta Doña Isabel (h. 10-12v). Representación del Conde de Champlite en que pretende la merced de Grande de España (h. 13-14). Papel de Don Alonso de Losada sobre la asistencia del ejército del Palatinado, 1625-1626 (h. 15-16v). Copia de un título original concediendo permiso para andar en coche al Regidor de la villa de Madrid Don Martín de Montalvo, 1611 (h. 19). Razón individual que remitió a Felipe IV Cristóbal de Benavente del reconocimiento que hizo de las provincias rebeldes, 1620 (h. 22-32v). Instrucción dada por Felipe IV a Don Gaspar Ruiz de Pereda, veedor general del ejército de Flandes, 1618 (h. 34-52v). Carta original del Padre Luis de la Puente a Doña Francisca de Luna (h. 54-55v). Declaración de la geografía por la Madre María de Jesús de Ágreda (h. 56-65v). Carta escrita por el general Don Gerónimo de Benavente Quiñones dirigida al embajador de España en Inglaterra, 1655 (h. 67-69v). Respuesta de un ministro al Rey Felipe IV sobre hacer o no las paces con Portugal, traducida del portugués (h. 71-76). Carta de Don Fernando de Guevara, abad de Santiago de Peñalba (h. 80-83v). Carta de Felipe IV al Cardenal de Sandoval, Arzobispo de Toledo, 1656 (h. 87-88). [Impreso son firmas manuscritas]: Escrituras de asiento y concordia que el Estado eclesiástico de las santas iglesias de la corona de Castilla y León otorgó en favor de Felipe IV, 1665 (h. 90-96v). Copia de la carta del Cardenal Mazarino al Conde de Peñaranda y respuesta, 1660 (h. 100-104v). Apuntaciones curiosas sacadas de la historia de España (h. 107-109v). Despacho de Felipe IV dirigido al Gobernador y contadurías del ejército sobre los absentistas del pan de munición estando el ejército en Extremadura, Derecho y administración pública en las Indias hispánicas: actas del XII Congreso Internacional de Historia del Derecho Indiano. Cuenca, 2002, Paz, América, Roca, Gayangos, Stradling, R. A.: Philip IV and the Government of Spain: 1621-1665. Cambridge, 1988, Pascual de Gayangos, En blanco las h. 7-9, 17-18, 20-21, 33, 53, 66, 70, 77-79, 84-86, 89, 98-99, 105-106, 110, 119-122, 132-133, 169-170, 175, 177, 185-186, 210-211, 220, 222-224, 226

67. Papeles varios de los reinados de Felipe III y Felipe IV [Manuscrito]

Author

Losada y Prada, Andrés de, Isabel Clara Eugenia, Infanta de España 1566-1633, Felipe IV, Rey de España, Montesclaros, Juan de Mendoza y Luna, Marqués de, Benavente y Benavides, Cristóbal de, Puente, Luis de la 1554-1624, María de Jesús de Ágreda 1602-1665, Benavente Quiñones, Jerónimo de fl. 1655-1661, Mazarin, Jules 1602-1661, Anaya Villanueva, Bartolomé de, Oquendo, Antonio de 1577-1640, Ciudad Real, Juan Alonso Idiáquez de Butrón y Múgica, Duque de m. 1653, Losada y Prada, Andrés de, Isabel Clara Eugenia, Infanta de España 1566-1633, Felipe IV, Rey de España, Montesclaros, Juan de Mendoza y Luna, Marqués de, Benavente y Benavides, Cristóbal de, Puente, Luis de la 1554-1624, María de Jesús de Ágreda 1602-1665, Benavente Quiñones, Jerónimo de fl. 1655-1661, Mazarin, Jules 1602-1661, Anaya Villanueva, Bartolomé de, Oquendo, Antonio de 1577-1640, and Ciudad Real, Juan Alonso Idiáquez de Butrón y Múgica, Duque de m. 1653

Abstract

Manuscritos e impresos, Originales y copias, Carta de Don Andrés de Losada al Marqués de Montes-Claros dándole noticias de la Infanta Doña Isabel (h. 1-2). Carta de la Infanta Doña Isabel a Felipe IV, 1625 (h. 3). Provisiones de Flandes de 1625 (h. 4). Carta del Marqués de Montes-Claros (h. 5). Partidas de 1625 (h. 6). Carta de Felipe a la Infanta Doña Isabel (h. 10-12v). Representación del Conde de Champlite en que pretende la merced de Grande de España (h. 13-14). Papel de Don Alonso de Losada sobre la asistencia del ejército del Palatinado, 1625-1626 (h. 15-16v). Copia de un título original concediendo permiso para andar en coche al Regidor de la villa de Madrid Don Martín de Montalvo, 1611 (h. 19). Razón individual que remitió a Felipe IV Cristóbal de Benavente del reconocimiento que hizo de las provincias rebeldes, 1620 (h. 22-32v). Instrucción dada por Felipe IV a Don Gaspar Ruiz de Pereda, veedor general del ejército de Flandes, 1618 (h. 34-52v). Carta original del Padre Luis de la Puente a Doña Francisca de Luna (h. 54-55v). Declaración de la geografía por la Madre María de Jesús de Ágreda (h. 56-65v). Carta escrita por el general Don Gerónimo de Benavente Quiñones dirigida al embajador de España en Inglaterra, 1655 (h. 67-69v). Respuesta de un ministro al Rey Felipe IV sobre hacer o no las paces con Portugal, traducida del portugués (h. 71-76). Carta de Don Fernando de Guevara, abad de Santiago de Peñalba (h. 80-83v). Carta de Felipe IV al Cardenal de Sandoval, Arzobispo de Toledo, 1656 (h. 87-88). [Impreso son firmas manuscritas]: Escrituras de asiento y concordia que el Estado eclesiástico de las santas iglesias de la corona de Castilla y León otorgó en favor de Felipe IV, 1665 (h. 90-96v). Copia de la carta del Cardenal Mazarino al Conde de Peñaranda y respuesta, 1660 (h. 100-104v). Apuntaciones curiosas sacadas de la historia de España (h. 107-109v). Despacho de Felipe IV dirigido al Gobernador y contadurías del ejército sobre los absentistas del pan de munición estando el ejército en Extremadura, Derecho y administración pública en las Indias hispánicas: actas del XII Congreso Internacional de Historia del Derecho Indiano. Cuenca, 2002, Paz, América, Roca, Gayangos, Stradling, R. A.: Philip IV and the Government of Spain: 1621-1665. Cambridge, 1988, Pascual de Gayangos, En blanco las h. 7-9, 17-18, 20-21, 33, 53, 66, 70, 77-79, 84-86, 89, 98-99, 105-106, 110, 119-122, 132-133, 169-170, 175, 177, 185-186, 210-211, 220, 222-224, 226

68. Correspondencia de Diego Sarmiento de Acuña, Conde de Gondomar [Manuscrito]

Author

Gondomar, Diego Sarmiento de Acuña, Conde de 1567-1626, Benavente y Benavides, Cristóbal de, San Juan, Pedro de, Spínola, Ambrosio 1569-1630, Lerma, Francisco Gómez de Sandoval y Rojas, Duque de 1553-1625, Oñate, Íñigo Vélez de Guevara y Tassis, Conde de 1597-1658, Bedmar, Alfonso de la Cueva, Marqués de 1572-1655, Belveder, Luis de Velasco, Marqués de, Añover, Luis Lasso de la Vega Conde de, Urquina, Mateo fl. 1622, Lendínez, Jorge de, Bucquoy, Charles Bonaventure de Longueval, Conde de, Maximiliano I, Elector de Baviera 1573-1651, Leopoldo V, Archiduque de Austria 1586-1632, Gondomar, Diego Sarmiento de Acuña, Conde de 1567-1626, Benavente y Benavides, Cristóbal de, San Juan, Pedro de, Spínola, Ambrosio 1569-1630, Lerma, Francisco Gómez de Sandoval y Rojas, Duque de 1553-1625, Oñate, Íñigo Vélez de Guevara y Tassis, Conde de 1597-1658, Bedmar, Alfonso de la Cueva, Marqués de 1572-1655, Belveder, Luis de Velasco, Marqués de, Añover, Luis Lasso de la Vega Conde de, Urquina, Mateo fl. 1622, Lendínez, Jorge de, Bucquoy, Charles Bonaventure de Longueval, Conde de, Maximiliano I, Elector de Baviera 1573-1651, and Leopoldo V, Archiduque de Austria 1586-1632

Abstract

Cartas, algunas cifradas, referentes principalmente a la Guerra del Palatinado, dirigidas al Conde de Gondomar por: Ambrosio Spínola, Marqués de los Balbases y de Spínola, Cristóbal de Benavente y Benavides, Pedro de San Juan, Duque de Lerma, Conde de Novelle, Marqués de Belveder, Conde de Añover, Juan Velasco, Mateo de Urquina, Fr. Iñigo de Brihuela, Jorge de Lendínez; y copias de las cartas del Conde de Oñate y del Rey al Marqués de Bedmar, embajador en Flandes, del Archiduque Leopoldo y del Conde de de Bucquoy al Marqués de Spínola, y del Duque Maximiliano de Baviera al Príncipe elector de Maguncia, remitidas de nuevo a Gondomar, Sellos de placa, Original con firmas autógrafas y copias, En Mss/18619: Nota autógrafa de Pascual de Gayangos en la h. I: Este libro y otros libros de cartas fueron de Don Francisco López de la Torre y Ayllón y Gallo, a cuyos herederos los compré en 1852, Roca, Gayangos, Cartas, algunas cifradas, referentes principalmente a la Guerra del Palatinado, dirigidas al Conde de Gondomar por: Ambrosio Spínola, Marqués de los Balbases y de Spínola, Cristóbal de Benavente y Benavides, Pedro de San Juan, Duque de Lerma, Conde de Novelle, Marqués de Belveder, Conde de Añover, Juan Velasco, Mateo de Urquina, Fr. Iñigo de Brihuela, Jorge de Lendínez; y copias de las cartas del Conde de Oñate y del Rey al Marqués de Bedmar, embajador en Flandes, del Archiduque Leopoldo y del Conde de de Bucquoy al Marqués de Spínola, y del Duque Maximiliano de Baviera al Príncipe elector de Maguncia, remitidas de nuevo a Gondomar, Francisco López de la Torre y Ayllón y Gallo, Pascual de Gayangos, Fechadas la mayoría en Bruselas entre enero y diciembre de 1620, y algunas en Viena, Languelois, Ruffochs, Marimont y Praga, Deteriorados los márgenes. Mal encuadernadas algunas h., la ubicación correcta sería: la h. 68, entre 63 y 64; la h. 127 entre la122 y 123; y la 160, entre la 151 y 152, Dos foliaciones en lápiz, en la más moderna pasa de la h. 232 a la 234. Varias h. en blanco

69. Papeles varios relativos a los reinados de Felipe II, Felipe III y Felipe IVh[Manuscrito]

Author

Toledo, Pedro de m. 1627, Peramoto, Alberto, Benavente y Benavides, Cristóbal de, Saboya, Carlos Manuel I, Duque de 1562-1630, Vera y Figueroa, Juan Antonio de, Conde de la Roca, Mazarin, Jules 1602-1661, Toledo, Pedro de m. 1627, Peramoto, Alberto, Benavente y Benavides, Cristóbal de, Saboya, Carlos Manuel I, Duque de 1562-1630, Vera y Figueroa, Juan Antonio de, Conde de la Roca, and Mazarin, Jules 1602-1661

Abstract

En h. 1 firma autógrafa de Gayangos, En h. 1: "Aunque rotulado por fuera Felipe II, todos los papeles contenidos en este tomo, exceptuando el 1º y algún otro del tiempo de Felipe 2º, corresponden al reinado de Felipe IV", Carta original de Felipe III a Fernando de Borja, para felicitar al gran duque de Toscana por el nacimiento de su hijo. Madrid, 26 diciembre, 1609 (h. 1-3). Siete dictámenes del consejero de Estado, Pedro de Toledo, sobre asuntos de la monarquía española. 1623 (h. 5-38). Copia de la carta del conde de Peñaranda, en respuesta a una del cardenal Mazarino. 15 febrero 1660 (h. 40-42). Papel sobre la extracción de la moneda de España a países extranjeros y explicación del valor de la moneda imaginaria (h. 44-51). Modo con que se enarboló el estandarte en Madrid, el 2 de mayo de 1621, habiéndose convocado a junta al Ayuntamiento por Francisco de Vallacis, conde de Peñaflor (h. 53-57). Carta del embajador en Francia, sobre la sesión que tuvo con el cardenal Richelieu y fray Josef, en materia de paces. 1634 (h. 59-71). Cartas originales del duque de Saboya, Carlos Emanuel, sobre las capitulaciones de paz hechas en Madrid con Felipe III. 1617 (h. 73-85). Artículos acordados con el príncipe de Orange para los eclesiásticos y magistrados de la ciudad de Maastrich (h. 86-87). Discurso del conde de la Roca, embajador en Venecia, dirigida a los señores que componían el gobierno. 1632 (h. 89-106). Papel dado por el conde de la Roca al senado de Venecia sobre la invasión de la Valtelina (h. 108-115). Papel de Alberto de Peramoto contra el proceder de España en materia de religión, entre los reinados de los Reyes Católicos y de Felipe IV y refutación del mismo (h. 123-169). Papel que prueba que los franceses faltaron a los capítulos de paz con España (h. 171-189). Razonamiento del rey de Francia sobre el rompimiento de la guerra contra el rey de España. 1635 (h. 191-203). Relación de lo sucedido con los principes de Saboya en los negocios políticos de su tiempo. 1642 (h. 206-219). Última declaración del cardenal Albornoz sobre las dudas que se ofrecieron en la Paz de Saboya y Génova. 1635 (h. 221-225). Relación de los sucesos de madama Leopoldina Henrietta Boleña (h. 226-229). Propo, Roca, Gayangos, Paz, América (2ª ed.), Pascual de Gayangos, Tít. del tejuelo: Reynado de Phelipe Tercero, Algunas h. en blanco

70. Advertencias para Reyes, Principes, y Embaxadores ...

Author

Benavente y Benavides, Cristóbal de, Martínez, Francisco fl. 1627-1645 imp., Benavente y Benavides, Cristóbal de, and Martínez, Francisco fl. 1627-1645 imp.

Abstract

Colofón, Sign.: [ ]², ¶⁴, A-Z⁸, 2A-2Z⁸, Portada grabada calcográfica : "Juan Noort fecit", La h. de lám. es un grabado calcográfico : "Juan de Noort fecit", retr. del príncipe Baltasar Carlos, en [ ]₂

71. [Retrato de Baltasar Carlos de Austria] [Material gráfico]

Author

Noort, Juan de 1587-1652, Benavente y Benavides, Cristóbal de Advertencias para Reyes, Principes, y Embaxadores ..., Martínez, Francisco fl. 1627-1645 imp., Noort, Juan de 1587-1652, Benavente y Benavides, Cristóbal de Advertencias para Reyes, Principes, y Embaxadores ..., and Martínez, Francisco fl. 1627-1645 imp.

Abstract

Inscripción: "DON BALTHASAR CARLOS PRINCIPE DE ESPAÑA", Iconografía Hispana, Barcia Retratos conservados en la B.N., Páez. Repertorio, El Antiguo Madrid : catálogo general ilustrado, 1926, Catálogo del Gabinete de Estampas del Museo Municipal de Madrid

72. Memorial del pleyto que los vezinos de la Abadia de Santander, que se llama san Cebrian, Beçama, Azoños, y Maoño, tratan. Con D. Christoual de venauente y Benauides, Abad de Santander, que primero se siguo con el Reuerendissimo Padre Maestro Fray Antonio de Sotomayor, Confessor de su Magestad, posseyendo la dicha Abadia

Author

Santa Cruz de Bezana, Benavente y Benavides, Cristóbal de demandado, Maoño Concejo demandante, Azoños Concejo demandante, Santa Cruz de Bezana, Benavente y Benavides, Cristóbal de demandado, Maoño Concejo demandante, and Azoños Concejo demandante

Abstract

Sobre separar los dichos lugares de la jurisdicción de la Abadia de Santander, Sobre separar los dichos lugares de la jurisdicción de la Abadia de Santander, Precede al título: [cristus], Título tomado de la cabecera del texto, Se ha respetado la puntuación original, Fecha aproximada de impresión tomada del final del texto: "en quatro de Março de 1634", Sign.: A-E², Inicial grabada, Apostillas marginales, Verso de la última hoja en blanco

73. Por los vezinos y lugares de san Cebrian, Beçana, Azonos, y Maono. Con El Abad de Santander, y el señor Fiscal

Author

Santa Cruz de Bezana, Benavente y Benavides, Cristóbal de demandado, Viuda de Juan González (fl.1633-1639) impresor, Maoño Concejo demandante, Azoños Concejo demandante, Santa Cruz de Bezana, Benavente y Benavides, Cristóbal de demandado, Viuda de Juan González (fl.1633-1639) impresor, Maoño Concejo demandante, and Azoños Concejo demandante

Abstract

Se ha respetado la puntuación original, Título tomado de la cabecera del texto, El pie de imprenta consta en el colofón, Sign.: A-E², F²⁻¹, En h. 1r grabado xilográfico con el anagrama de la Compañía de Jesús: "IHS", Inicial grabada

74. Por don Christoual de Benauente y Benauides Abad de Santander, en la causa que trata con Los lugares de san Cebrian, Bezano, Maono, y Azoños. Sobre La jusrisdiccion de los dichos lugares, y possession della

Author

Benavente y Benavides, Cristóbal de, Viuda de Juan González (fl.1633-1639) impresor, Santa Cruz de Bezana demandado, Maoño Concejo demandado, Azoños Concejo demandado, Benavente y Benavides, Cristóbal de, Viuda de Juan González (fl.1633-1639) impresor, Santa Cruz de Bezana demandado, Maoño Concejo demandado, and Azoños Concejo demandado

Abstract

Se ha respetado la puntuación original, Título tomado de la cabecera del texto, El pie de imprenta consta en el colofón, Sign.: A-H², En h. 1r grabado xilográfico con el anagrama de la Compañía de Jesús: "IHS", Inicial grabada

75. Por don Cristoual de Benauides y Benauente Abad de Santander. Con Los lugares de S. Cebrian, Becano, Moano, y Azonos. Sobre La juridicion de los dichos lugares, y possession della

Author

Benavente y Benavides, Cristóbal de, Santa Cruz de Bezana demandado, Maoño Concejo demandado, Azoños Concejo demandado, Benavente y Benavides, Cristóbal de, Santa Cruz de Bezana demandado, Maoño Concejo demandado, and Azoños Concejo demandado

Abstract

Se ha respetado la puntuación original, Título tomado de la cabecera del texto, Precede al título: [cristus], Fecha aproximada de impresión deducida de otros papeles del mismo pleito, Sign.: A⁴, Inicial grabada, Apostillas marginales

76. Adicion breue, hecha en segunda instancia, en virtud de decretro del Consejo, al memorial del pleyto que los vezinos del Abadia de Santander, que se lñlama San Cebrian, Beçama, y Açoños, y Maoño, tratan con Don Christoual de Benauente y Benauides, Abad de Santander, que primero se siguio con el Reuerendissimo Padre Maestro fray Antonio de Sotomayor, Confessor de su Magestad, posseyendo la dicha Abadia

Author

Benavente y Benavides, Cristóbal de litigante, Santa Cruz de Bezana litigante, Azoños Concejo litigante, Maoño Concejo litigante, Benavente y Benavides, Cristóbal de litigante, Santa Cruz de Bezana litigante, Azoños Concejo litigante, and Maoño Concejo litigante

Abstract

Sobre separar los dichos lugares de la jurisdicción de la Abadia de Santander, Sobre separar los dichos lugares de la jurisdicción de la Abadia de Santander, Precede al título: [cristus], Título tomado de la cabecera del texto, Se ha respetado la puntuación original, Fecha aproximada de impresión tomada del final del texto: "En 23 de Mayo de 1635", Sign.: A-B², C²⁻¹, Inicial grabada

79. Papeles varios genealógicos y jurídicos [Manuscrito]

Author

Ascargorta, Domingo de Origen de los Condes Duques de Benavente y su apellido Pimentel and Ascargorta, Domingo de Origen de los Condes Duques de Benavente y su apellido Pimentel

Abstract

Manuscritos e impresos, [Impreso]: [Solicitud de graduación de General de Artillería por D. Rodrigo Gudinez Brochero y Texeda, Governador de la frontera de Zamora].-- [S.l.: s.n., s.a.].-- 2 h. ; Fol. (h. 1-2). [Impreso]: Relacion de servicios del Capitan de Mar, y Guerra Don Francisco Guiral.- [S.l.: s.n., 1715?].- 3 p.; Fol.- Sign.: A±2÷ (h. 3-4). [Impreso]: Relacion de servicios del Sargento Mayor Don Manvuel de Villarreal.-- [S.l.: s.n., 1688?].- [4] h. ; Fol.- Sign.: A±2÷ (h. 5-8). [Impreso]: Copia de carta... al Emperador, por el General Conde de Sussa, desde la Plaça de Lebenz, en veinte de julio deste año de 1664.- En Madrid: Por Francisco Nieto, 1664.- [2] h. ; Fol. (h. 9-10). [Impreso]: Por Don Pedro Pasqval de Ibarra, natural de Alicante, con D. Francisco Pasqual de Ibarra... sobre que se le den dos mil libras para el homenage de casa.- [S.l.: s.n., s.a.].- 27 p. ; Fol.- Sig.: A-N±2÷, O±1÷ (h. 11-37v). [Impreso]: Trasvmpto de el Memorial de la calidad y servicios.... de Don Joseph Alfonso de Guerra, y Villegas.- [S.l.: s.n., s.a.].-- 10 h.; Fol.- Sign.: A-E±2÷ (h. 38-47). [Impreso]: Por Carlos Perez de Sarrio Generoso... con Francisco Sanchez Generoso en el pleito de svplicacion de la sentencia que declaro a favor de Carlos Perez de Sarrio la succession en el mayorazgo.- [S.l.: s.n., 1693?].- 43 p.; Fol.- Sign.: A-L±2÷ (h. 48-69). [Impreso]: [Sobre el Memorial enviado a S.M., en nombre del Príncipe de Paternó, contra el Virrey de Sicilia].- [S.l.: s.n., s.a.].- 62 p. ; Fol.- Sign.: A-H±4÷ (h. 87-117v). [Papeles referentes a la Casa de los Condes de Benavente]: Décima de Juan de Arenillas: Domingo, en vuestra elocuencia / quien aqueste libro mira (h. 122v); Idem de Juan Fernández de Perea: Segunda inmortalidad / deban Domingo elocuente (h. 122v); Testamento de Alfonso Jiraldez (1330) sacado en 1687 (h. 123-127); Detención de Alfonso Pimentel por orden de Juan II, 1451 (h. 129-131; Donación de Alfonso [i.e. Enrique IV] al Conde de Benavente de los bienes enajenados a Luis de Melga, Castro, Américo, Quevedo, El Buscón; advertencias y notas, en Clásicos castellanos, Galván Desvaux, Daniel, Felipe IV y la defensa del valimiento : el proceso contra el Duque de Uceda, Universidad de Valladolid, 2016. [Ed. y estudio de Memorial de pleyto qve Don Juan Chumacero y Sotomayor..., trata con el Duque de Vzeda], García Cubero, Quevedo, Francisco de, Obras completas. T. II: Obras en verso. Estudio preliminar, ed. y notas de Felicidad Buendía, Madrid, 1964, Pérez Marcos, Regina, El Duque de Uceda, en Los validos, José Antonio Escudero (coord.), Madrid, 2004, Domingo, en vuestra elocuencia / quien aqueste libro mira... (h. 122v), Segunda inmortalidad / deban Domingo elocuente... (h. 122v), A vuestro ingenio, el morir / con justa razón llamamos (h. 135), Domingo, tan felizmente / hoy vuestro ingenio se atreve... (h. 135), Hoy que a tu alabanza exhorto / (Domingo) mi musa, en suma... (h. 135v), La poderosa energía / de tu cuidado señor... (h. 135v), Si en cosas grandes basta haber querido / disculpa tiene ya mi atrevimiento... (h. 136r), Juan Alfonso Guerra y Sandoval, Varias h. en blanco. Pérdida de soporte en las h. 172 y 298, Algunos documentos mal encuadernados, Escudo de los Condes de Benavente, en h. 122

80. Advertencias para Reyes, Principes, y Embaxadores ...

Author

Martínez, Francisco, fl. 1627-1645, imp, Noort, Juan de, 1587-1652, grab, Benavente y Benavides, Cristóbal de, n. 1582, Martínez, Francisco, fl. 1627-1645, imp, Noort, Juan de, 1587-1652, grab, and Benavente y Benavides, Cristóbal de, n. 1582

Abstract

Copia digital : Biblioteca Digital Hispánica (Biblioteca Nacional de España), Copia digital : Google Books, Título tomado del epígrafe, Tít. tomado del epígrafe, Colofón, Sign.: [ ]\p2\s, ¶\p4\s, A-Z\p8\s, 2A-2Z\p8\s, Texto con doble fileteado, Portada grabada calcográfica: "Juan Noort fecit", Sign.: [ ]\p2\s, [calderón]\p4\s, A-Z\p8\s, 2A-2Z\p8\s, Port. grab. calc.: "Juan Noort fecit", La hoja de grabado calcográfico: "Juan de Noort fecit", retrato del príncipe Baltasar Carlos, en [ ]\b2\s, La h. de grab. calc.: "Juan de Noort fecit", retr. del príncipe Baltasar Carlos, en [ ]\b2\s

82. ¡Madre!

Author

Benavente y Martínez, Jacinto

Published
1915

83. Un oso.

Author

Benavente y Martínez, Jacinto

Published
1918

86. Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium

Author

Areti Lagiou, María Rubín-García, Nuria Aragonés, Akihisa Hidaka, Lina Mu, Matteo Rota, Weimin Ye, Vicente Martín, Yolanda Benavente, Carlo La Vecchia, Monica Ferraroni, Nuno Lunet, Mohammadreza Pakseresht, Domenico Palli, Dmitry Maximovich, Farhad Pourfarzi, Zuo-Feng Zhang, Shoichiro Tsugane, Amelie Plymoth, Manuela García-de-la-Hera, Roberta Pastorino, Gerson Shigueaki Hamada, Reza Malekzadeh, Pagona Lagiou, Jesús Vioque, Gemma Castaño-Vinyals, Facundo Vitelli-Storelli, Samantha Morais, Claudio Pelucchi, Guo-Pei Yu, David Zaridze, Stefania Boccia, Eva Negri, Rossella Bonzi, Instituto de Saúde Pública da Universidade do Porto, Vitelli-Storelli F., Rubin-Garcia M., Pelucchi C., Benavente Y., Bonzi R., Rota M., Palli D., Ferraroni M., Lunet N., Morais S., Ye W., Plymoth A., Malekzadeh R., Tsugane S., Hidaka A., Aragones N., Castano-Vinyals G., Zaridze D.G., Maximovich D., Vioque J., Garcia-de-la-Hera M., Zhang Z.-F., Hamada G.S., Pakseresht M., Pourfarzi F., Mu L., Boccia S., Pastorino R., Yu G.-P., Lagiou A., Lagiou P., Negri E., Vecchia C.L., and Martin V.

Subjects
Cancer Research, medicine.medical_specialty, Stomach cancer, Pooling, Oncology and Carcinogenesis, Article, Stomach--Cancer, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, Family history, Gastric cancer, International consortium, Meta-analyses, Socioeconomic status, Settore MED/42 - IGIENE GENERALE E APPLICATA, RC254-282, Cancer, family history, Medical records, business.industry, Prevention, gastric cancer, Càncer d'estómac, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Odds ratio, medicine.disease, Confidence interval, Oncology, international consortium, meta-analyses, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Digestive Diseases, business, Històries clíniques
Abstract

Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64–2.04, I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82, 95% CI: 1.59–2.05 for subjects with FH) than for cardia GC (OR = 1.38, 95% CI: 0.98–1.77), and for the intestinal (OR = 1.92, 95% CI: 1.62–2.23) than for the diffuse histotype (OR = 1.62, 95% CI: 1.28–1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance.

Published
2021

87. Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Author

Amy Moore, Eleanor Kane, Zhaoming Wang, Orestis A. Panagiotou, Lauren R. Teras, Alain Monnereau, Nicole Wong Doo, Mitchell J. Machiela, Christine F. Skibola, Susan L. Slager, Gilles Salles, Nicola J. Camp, Paige M. Bracci, Alexandra Nieters, Roel C. H. Vermeulen, Joseph Vijai, Karin E. Smedby, Yawei Zhang, Claire M. Vajdic, Wendy Cozen, John J. Spinelli, Henrik Hjalgrim, Graham G. Giles, Brian K. Link, Jacqueline Clavel, Alan A. Arslan, Mark P. Purdue, Lesley F. Tinker, Demetrius Albanes, Giovanni M. Ferri, Thomas M. Habermann, Hans-Olov Adami, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul Brennan, Angela R. Brooks-Wilson, Federico Canzian, Lucia Conde, David G. Cox, Karen Curtin, Lenka Foretova, Susan M. Gapstur, Hervé Ghesquières, Martha Glenn, Bengt Glimelius, Rebecca D. Jackson, Qing Lan, Mark Liebow, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Lindsay M. Morton, Kari E. North, Kenneth Offit, Marina Padoan, Alpa V. Patel, Sara Piro, Vignesh Ravichandran, Elio Riboli, Silvia de Sanjose, Richard K. Severson, Melissa C. Southey, Anthony Staines, Carolyn Stewart, Ruth C. Travis, Elisabete Weiderpass, Stephanie Weinstein, Tongzhang Zheng, Stephen J. Chanock, Nilanjan Chatterjee, Nathaniel Rothman, Brenda M. Birmann, James R. Cerhan, Sonja I. Berndt, Moore A., Kane E., Wang Z., Panagiotou O.A., Teras L.R., Monnereau A., Wong Doo N., Machiela M.J., Skibola C.F., Slager S.L., Salles G., Camp N.J., Bracci P.M., Nieters A., Vermeulen R.C.H., Vijai J., Smedby K.E., Zhang Y., Vajdic C.M., Cozen W., Spinelli J.J., Hjalgrim H., Giles G.G., Link B.K., Clavel J., Arslan A.A., Purdue M.P., Tinker L.F., Albanes D., Ferri G.M., Habermann T.M., Adami H.-O., Becker N., Benavente Y., Bisanzi S., Boffetta P., Brennan P., Brooks-Wilson A.R., Canzian F., Conde L., Cox D.G., Curtin K., Foretova L., Gapstur S.M., Ghesquieres H., Glenn M., Glimelius B., Jackson R.D., Lan Q., Liebow M., Maynadie M., McKay J., Melbye M., Miligi L., Milne R.L., Molina T.J., Morton L.M., North K.E., Offit K., Padoan M., Patel A.V., Piro S., Ravichandran V., Riboli E., de Sanjose S., Severson R.K., Southey M.C., Staines A., Stewart C., Travis R.C., Weiderpass E., Weinstein S., Zheng T., Chanock S.J., Chatterjee N., Rothman N., Birmann B.M., Cerhan J.R., and Berndt S.I.

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Chronic lymphocytic leukemia, Follicular lymphoma, diffuse large B-cell lymphoma, Single-nucleotide polymorphism, Genome-wide association study, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, follicular lymphoma, immune system diseases, Internal medicine, hemic and lymphatic diseases, Genetics, Medicine, Leucèmia limfocítica crònica, genetics, Original Research, Genetic association, Cancer och onkologi, business.industry, non-Hodgkin lymphoma, Odds ratio, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, marginal zone lymphoma, Lymphoma, Malaltia de Hodgkin, 030104 developmental biology, Cancer and Oncology, 030220 oncology & carcinogenesis, polygenic risk score, diffuse large B-celllymphoma, chronic lymphocytic leukemia, Hodgkin's disease, genetic, business, Diffuse large B-cell lymphoma, Genètica, height
Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

Published
2020

88. Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Author

Paul Brennan, M. G. Ennas, Qing Lan, Sasha Bernatsky, Alan A. Arslan, Peter Kraft, Lohith Madireddy, Roel Vermeulen, Kenan Onel, Graham G. Giles, John J. Spinelli, Eleanor Kane, Bengt Glimelius, Alexandra Nieters, David V. Conti, Christine F. Skibola, Pouya Khankhanian, Amy Moore, Ruth C. Travis, Mads Melbye, Sonja I. Berndt, Mark Liebow, Lauren R. Teras, Pierluigi Cocco, Lennox Din, Alain Monnereau, Mark P. Purdue, Lenka Foretova, Stephen J. Chanock, Stephen M. Ansell, Angela Brooks-Wilson, Wendy Cozen, Kenneth Offit, Demetrius Albanes, Anne J. Novak, Melissa C. Southey, Paolo Boffetta, Nicola J. Camp, James R. Cerhan, Rudolph Kaaks, Silvia de Sanjosé, Karen Curtin, Sophia S. Wang, James McKay, Nicole Wong Doo, Hans-Olov Adami, Tongzhang Zheng, Claire M. Vajdic, Nisha Pradhan, Giacomo Muzi, Gilles Salles, Nathaniel Rothman, Yolanda Benavente, Marc Maynadié, Brian K. Link, Delphine Casabonne, Hervé Ghesquières, Joseph Vijai, Karin E. Smedby, Paige M. Bracci, David G. Cox, Brenda M. Birmann, Lucia Miligi, Carolyn Stewart, Lucia Conde, Leonid Padyukov, Eve Roman, Richard K. Severson, Jorge R. Oksenberg, Immaculata De Vivo, Yawei Zhang, Corrado Magnani, Jacqueline Clavel, Lindsay M. Morton, Corinne Haioun, Jonathan N. Hofmann, Karen H. Costenbader, Pierre-Antoine Gourraud, Mohammad Sheikh, Stephanie J. Weinstein, Susan L. Slager, Paolo Vineis, Nikitha Kosaraju, Zachary Taub, Henrik Hjalgrim, Roger L. Milne, Morris Din, Martha Glenn, Nikolaus Becker, Timothy J. Vyse, Thomas M. Mack, Anthony Staines, Department of Medicine, Clinical Epidemiology, McGill University Health Center [Montreal] (MUHC), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Emory University [Atlanta, GA], Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, Germany, International Agency for Cancer Research (IACR), Department of Public Health, Vientiane Municipality, Registre des hémopathies malignes de Côte d'Or, Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University, GRAPHOS - IFROSS Recherche, Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon, Faculty of Medicine, Section of Rheumatology, Imperial College London, Karolinska Institutet [Stockholm], Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Chemistry and Biochemistry [Boulder], University of Colorado [Boulder], Uppsala Universitet [Uppsala], Carver College of Medicine, University of Iowa, Service d'hématologie clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Division of Cancer Epidemiology and Genetics, National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Health Sciences, University of York [York, UK], Service de Radio-Oncologie [Lyon], Hospices Civils de Lyon (HCL)-Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), University of Melbourne, Centre Léon Bérard [Lyon], Mayo Clinic [Rochester], Occupational and Environmental Epidemiology Branch [Bethesda, Maryland], Division of Cancer Epidemiology and Genetics [Bethesda, Maryland], National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH)-National Cancer Institute [Bethesda] (NCI-NIH), Memorial Sloane Kettering Cancer Center [New York], Huntsman Cancer Institute, Clinical Genetics Service, ISPO - Cancer Prevention and Research Institute, Unit of Environmental and Occupational Epidemiology, Dept. of Epidemiology Research, Statens Serum Institut [Copenhagen], B.B. Brodie Department of Neuroscience, Department of Pathology, Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Unit of Environment Cancer Epidemiology, IARC, University of Torino and CPO-Piemonte, Università degli studi di Torino (UNITO), Department of Epidemiology, Harvard School of Public Health, Wayne State University [Detroit], Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Cancer Epidemiology Centre, Cancer Council Victoria, Cancer Epidemiology Unit, University of Oxford [Oxford], De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies (MONARIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Catalan Institute of Oncology (ICO), Department of Neurology [San Francisco, CA, USA], University of California [San Francisco] (UCSF), University of California-University of California, Norris Comprehensive Cancer Center, Masaryk University [Brno] (MUNI), Università degli studi di Torino = University of Turin (UNITO), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), Imperial College London, University of Oxford, Din L., Sheikh M., Kosaraju N., Smedby K.E., Bernatsky S., Berndt S.I., Skibola C.F., Nieters A., Wang S., McKay J.D., Cocco P., Maynadie M., Foretova L., Staines A., Mack T.M., de Sanjose S., Vyse T.J., Padyukov L., Monnereau A., Arslan A.A., Moore A., Brooks-Wilson A.R., Novak A.J., Glimelius B., Birmann B.M., Link B.K., Stewart C., Vajdic C.M., Haioun C., Magnani C., Conti D.V., Cox D.G., Casabonne D., Albanes D., Kane E., Roman E., Muzi G., Salles G., Giles G.G., Adami H.-O., Ghesquieres H., De Vivo I., Clavel J., Cerhan J.R., Spinelli J.J., Hofmann J., Vijai J., Curtin K., Costenbader K.H., Onel K., Offit K., Teras L.R., Morton L., Conde L., Miligi L., Melbye M., Ennas M.G., Liebow M., Purdue M.P., Glenn M., Southey M.C., Din M., Rothman N., Camp N.J., Wong Doo N., Becker N., Pradhan N., Bracci P.M., Boffetta P., Vineis P., Brennan P., Kraft P., Lan Q., Severson R.K., Vermeulen R.C.H., Milne R.L., Kaaks R., Travis R.C., Weinstein S.J., Chanock S.J., Ansell S.M., Slager S.L., Zheng T., Zhang Y., Benavente Y., Taub Z., Madireddy L., Gourraud P.-A., Oksenberg J.R., Cozen W., Hjalgrim H., Khankhanian P., and Le Bihan, Sylvie

Subjects
Oncology, Male, Multifactorial Inheritance, Lymphoma, Epidemiology, Chronic lymphocytic leukemia, Follicular lymphoma, Genome-wide association study, Disease, Neurodegenerative, meta-analysi, immune system diseases, HLA Antigens, Risk Factors, hemic and lymphatic diseases, 2.1 Biological and endogenous factors, HLA Antigen, Aetiology, Genetics (clinical), Cancer, Allele, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Lymphoma, Non-Hodgkin, non-Hodgkin lymphoma, 030305 genetics & heredity, Single Nucleotide, Hematology, Middle Aged, 3. Good health, Public Health and Health Services, Female, Human, medicine.medical_specialty, autoimmune disease, genome-wide association study, meta-analysis, Alleles, Autoimmune Diseases, Humans, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Non-Hodgkin, Article, 03 medical and health sciences, Rare Diseases, Internal medicine, Genetic variation, medicine, Genetics, Polymorphism, 030304 developmental biology, Autoimmune disease, business.industry, Multiple sclerosis, Risk Factor, Arthritis, Inflammatory and immune system, Human Genome, medicine.disease, Brain Disorders, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Published
2019

89. Temática popular en la Antígona de Sófocles y en algunas de sus recreaciones en la Europa del siglo XX: J. M. Pemán, S. Espriu, J. Dantas, J. Anouilh, J. Cocteau y B. Brecht

Author

Vico Burgos, Ramón, Benavente y Barreda, Mariano, Camacho Rojo, José María, and Universidad de Granada. Departamento de Filología Griega

Subjects
82.091, Sófocles, 495-405 (a. C.), Antígona (Mitología griega), 807.5, 159.97, Filología Griega
Abstract

Tesis Univ. Granada. Departamento de Filología Griega. Leída el 10 de mayo de 2012

Published
2018

90. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author

Mariagrazia Zucca, Thomas M. Habermann, Lauren R. Teras, Joseph Vijai, Lenka Foretova, Simon Crouch, Anneclaire J. De Roos, Jacqueline Clavel, Lindsay M. Morton, Melissa C. Southey, W. Ryan Diver, Patrick M. Gaffney, James McKay, Eve Roman, Sophia S. Wang, Mark P. Purdue, Hans-Olov Adami, Gilles Salles, Jarmo Virtamo, Yan W. Asmann, Angela Brooks-Wilson, Thierry Jo Molina, Andrew D. Zelenetz, Ahmet Dogan, Kenneth Offit, Peter Kraft, Gianluca Severi, Zhaoming Wang, Tongzhang Zheng, Sonja I. Berndt, Brian K. Link, Sasha Bernatsky, Theodore R. Holford, Emanuele Angelucci, Paige M. Bracci, Martyn T. Smith, Stephen J. Chanock, Brenda M. Birmann, Hervé Ghesquières, Stephen M. Ansell, Paolo Vineis, Mads Melbye, Kari E. North, Jenny Turner, Jacques Riby, Charles E. Lawrence, Alain Monnereau, Nikolaus Becker, Lucia Conde, James R. Cerhan, Susan L. Slager, Demetrius Albanes, Henrik Hjalgrim, Hervé Tilly, Héctor A. Velásquez García, Rebecca D. Jackson, Ann E. Clarke, Elizabeth A. Holly, Robert J. Klein, Paolo Boffetta, Mark Liebow, Karin E. Smedby, Marco Rais, David G. Cox, Patricia Hartge, Rosalind Ramsey-Goldman, Rachel S. Kelly, Lesley F. Tinker, Christine F. Skibola, Wendy Cozen, Tracy Lightfoot, Anne J. Novak, Heiner Boeing, Roel Vermeulen, Claire M. Vajdic, Bengt Glimelius, Kimberly A. Bertrand, Marc Maynadie, Eleanor Kane, Nathaniel Rothman, Yolanda Benavente, Paul Brennan, Anne Tjønneland, John J. Spinelli, Qing Lan, Anne Kricker, Alex Smith, Anthony Staines, Graham G. Giles, Carrie A. Thompson, Thomas E. Witzig, Stephanie J. Weinstein, Karen H. Cotenbader, Corinne Haioun, Anne Zeleniuch-Jacquotte, Simonetta Di Lollo, Alexandra Nieters, Rudolph Kaaks, Silvia de Sanjosé, Richard K. Severson, Yawei Zhang, Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Oklahoma Medical Research Foundation, Registre des hémopathies malignes de Côte d'Or, Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Université Bourgogne Franche-Comté ( UBFC ), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), University of Calgary, Bernatsky, S. and García, H.A.V. and Spinelli, J.J. and Gaffney, P. and Smedby, K.E. and Ramsey-Goldman, R. and Wang, S.S. and Adami, H.-O. and Albanes, D. and Angelucci, E. and Ansell, S.M. and WAsmann, Y. and Becker, N. and Benavente, Y. and Berndt, S.I. and Bertrand, K.A. and Birmann, B.M. and Boeing, H. and Boffetta, P. and Bracci, P.M. and Brennan, P. and Brooks-Wilson, A.R. and Cerhan, J.R. and Chanock, S.J. and Clavel, J. and Conde, L. and Cotenbader, K.H. and Cox, D.G. and Cozen, W. and Crouch, S. and De Roos, A.J. and De Sanjose, S. and Di Lollo, S. and Diver, W.R. and Dogan, A. and Foretova, L. and Ghesquières, H. and Giles, G.G. and Glimelius, B. and Habermann, T.M. and Haioun, C. and Hartge, P. and Hjalgrim, H. and Holford, T.R. and Holly, E.A. and Jackson, R.D. and Kaaks, R. and Kane, E. and Kelly, R.S. and Klein, R.J. and Kraft, P. and Kricker, A. and Lan, Q. and Lawrence, C. and Liebow, M. and Lightfoot, T. and Link, B.K. and Maynadie, M. and McKay, J. and Melbye, M. and Molina, T.J. and Monnereau, A. and Morton, L.M. and Nieters, A. and North, K.E. and Novak, A.J. and Offit, K. and Purdue, M.P. and Rais, M. and Riby, J. and Roman, E. and Rothman, N. and Salles, G. and Severi, G. and Severson, R.K. and Skibola, C.F. and Slager, S.L. and Smith, A. and Smith, M.T. and Southey, M.C. and Staines, A. and Teras, L.R. and Thompson, C.A. and Tilly, H. and Tinker, L.F. and Tjonneland, A. and Turner, J. and Vajdic, C.M. and Vermeulen, R.C.H. and Vijai, J. and Vineis, P. and Virtamo, J. and Wang, Z. and Weinstein, S. and Witzig, T.E. and Zelenetz, A. and Zeleniuch-Jacquotte, A. and Zhang, Y. and Zheng, T. and Zucca, M. and Clarke, A.E., McGill University Health Center [Montreal] (MUHC), Oklahoma Medical Research Foundation (OMRF), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, and dIRAS RA-I&I RA

Subjects
Oncology, medicine.medical_specialty, Immunology, Single-nucleotide polymorphism, Genome-wide association study, [SDV.CAN]Life Sciences [q-bio]/Cancer, lymphoma, Human leukocyte antigen, Bioinformatics, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Internal medicine, medicine, SNP, 030203 arthritis & rheumatology, Systemic lupus erythematosus, business.industry, General Medicine, medicine.disease, Systemic lupus, Lupus Nephritis, Risk of diffuse large B-cell lymphoma, 3. Good health, Lymphoma, 030220 oncology & carcinogenesis, business, Diffuse large B-cell lymphoma, IRF5, malignancy
Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE. © 2017 BMJ Publishing Group. All rights reserved.

Published
2017

91. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Author

Law, Philip J, Berndt, Sonja I, Speedy, Helen E, Camp, Nicola J, Sava, Georgina P, Skibola, Christine F, Holroyd, Amy, Vijai, Joseph, Sunter, Nicola J, Nieters, Alexandra, Bea, Silvia, Pettitt, AR, Monnereau, Alain, Martin-Garcia, David, Goldin, Lynn R, Clot, Guillem, Teras, Lauren R, Quintela, Inés, Birmann, Brenda M, Jayne, Sandrine J, Cozen, Wendy, Majid, Aneela, Smedby, Karin E, Lan, Qing, Dearden, Claire, Brooks-Wilson, Angela R, Hall, Andrew G, Purdue, Mark P, Mainou-Fowler, Tryfonia, Vajdic, Claire M, Jackson, Graham H, Cocco, Pierluigi, Marr, Helen, Zhang, Yawei, Zheng, Tongzhang, Giles, Graham G, Lawrence, Charles, Call, Timothy G, Liebow, Mark, Melbye, Mads, Glimelius, Bengt, Mansouri, Larry, Glenn, Martha, Curtin, Karen, Diver, W Ryan, Link, Brian K, Conde, Lucia, Bracci, Paige M, Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, Mckay, James, Albanes, Demetrius, Weinstein, Stephanie, Wang, Zhaoming, Caporaso, Neil E, Morton, Lindsay M, Severson, Richard K, Riboli, Elio, Vineis, Paolo, Vermeulen, Roel CH, Southey, Melissa C, Milne, Roger L, Clavel, Jacqueline, Topka, Sabine, Spinelli, John J, Kraft, Peter, Ennas, Maria Grazia, Summerfield, Geoffrey, Ferri, Giovanni M, Harris, Robert J, Miligi, Lucia, Pettitt, Andrew R, North, Kari E, Allsup, David J, Fraumeni, Joseph F, Bailey, James R, Offit, Kenneth, Pratt, Guy, Hjalgrim, Henrik, Pepper, Chris, Chanock, Stephen J, Fegan, Chris, Rosenquist, Richard, Sanjose, Silvia de, Carracedo, Angel, Dyer, Martin JS, Catovsky, Daniel, Campo, Elias, Cerhan, James R, Allan, James M, Rothman, Nathanial, Houlston, Richard, Slager, Susan, Law, P.J., Berndt, S.I., Speedy, H.E., Camp, N.J., Sava, G.P., Skibola, C.F., Holroyd, A., Joseph, V., Sunter, N.J., Nieters, A., Bea, S., Monnereau, A., Martin-Garcia, D., Goldin, L.R., Clot, G., Teras, L.R., Quintela, I., Birmann, B.M., Jayne, S., Cozen, W., Majid, A., Smedby, K.E., Lan, Q., Dearden, C., Brooks-Wilson, A.R., Hall, A.G., Purdue, M.P., Mainou-Fowler, T., Vajdic, C.M., Jackson, G.H., Cocco, P., Marr, H., Zhang, Y., Zheng, T., Giles, G.G., Lawrence, C., Call, T.G., Liebow, M., Melbye, M., Glimelius, B., Mansouri, L., Glenn, M., Curtin, K., Diver, W.R., Link, B.K., Conde, L., Bracci, P.M., Holly, E.A., Jackson, R.D., Tinker, L.F., Benavente, Y., Boffetta, P., Brennan, P., Maynadie, M., McKay, J., Albanes, D., Weinstein, S., Wang, Z., Caporaso, N.E., Morton, L.M., Severson, R.K., Riboli, E., Vineis, P., Vermeulen, R.C.H., Southey, M.C., Milne, R.L., Clavel, J., Topka, S., Spinelli, J.J., Kraft, P., Ennas, M.G., Summerfield, G., Ferri, G.M., Harris, R.J., Miligi, L., Pettitt, A.R., North, K.E., Allsup, D.J., Fraumeni, J.F., Jr., Bailey, J.R., Offit, K., Pratt, G., Hjalgrim, H., Pepper, C., Chanock, S.J., Fegan, C., Rosenquist, R., De Sanjose, S., Carracedo, A., Dyer, M.J.S., Catovsky, D., Campo, E., Cerhan, J.R., Allan, J.M., Rothman, N., Houlston, R., and Slager, S.

Subjects
Lymphocytic leukaemia
Abstract

Several chronic 14175 lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10-13), 1q42.13 (rs41271473, P=1.06 × 10-10), 4q24 (rs71597109, P=1.37 × 10 -10), 4q35.1 (rs57214277, P=3.69 × 10-8), 6p21.31 (rs3800461, P=1.97 × 10-8), 11q23.2 (rs61904987, P=2.64 × 10-11), 18q21.1 (rs1036935, P=3.27 × 10-8), 19p13.3 (rs7254272, P=4.67 × 10-8) and 22q13.33 (rs140522, P=2.70 × 10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.

Published
2017

92. Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project

Author

Paolo Boffetta, John J. Spinelli, Jennifer Turner, Dennis D. Weisenburger, Luigino Dal Maso, Christine F. Skibola, Joanne S. Colt, Marc Maynadié, Marshall E. Kadin, Anneclaire J. De Roos, Sonja I. Berndt, Joshua N. Sampson, Lucia Miligi, James R. Cerhan, Susan L. Slager, Eve Roman, Silvia Franceschi, Jacqueline Clavel, Karin E. Smedby, Andrea Martine 't Mannetje, Carlo La Vecchia, Paige M. Bracci, Martha S. Linet, Yolanda Benavente, Michael Spriggs, Lindsay M. Morton, Eleanor Kane, Christina A. Clarke, Alain Monnereau, Silvia de Sanjosé, Claire M. Vajdic, Adele Seniori Costantini, Alexandra Nieters, Yawei Zhang, Pierluigi Cocco, Brian C.-H. Chiu, Mads Melbye, Jennifer L. Kelly, Sam M. Mbulaiteye, Anne Kricker, Aaron D. Norman, Dennis P. Robinson, Sophia S. Wang, Morton, L.M., Sampson, J.N., Cerhan, J.R., Turner, J.J., Vajdic, C.M., Wang, S.S., Smedby, K.E., De Sanjosé, S., Monnereau, A., Benavente, Y., Bracci, P.M., Chiu, B.C.H., Skibola, C.F., Zhang, Y., Mbulaiteye, S.M., Spriggs, M., Robinson, D., Norman, A.D., Kane, E.V., Spinelli, J.J., Kelly, J.L., La Vecchia, C., Maso, L.D., Maynadié, M., Kadin, M.E., Cocco, P., Costantini, A.S., Clarke, C.A., Roman, E., Miligi, L., Colt, J.S., Berndt, S.I., Mannetje, A., de Roos, A.J., Kricker, A., Nieters, A., Franceschi, S., Melbye, M., Boffetta, P., Clavel, J., Linet, M.S., Weisenburger, D.D., and Slager, S.L.

Subjects
Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Adolescent, Chronic lymphocytic leukemia, Follicular lymphoma, Non-Hodgkin lymphoma (NHL), Article, Lymphoplasmacytic Lymphoma, Young Adult, Risk Factors, immune system diseases, hemic and lymphatic diseases, Internal medicine, Epidemiology of cancer, Prevalence, medicine, Humans, Aged, Aged, 80 and over, Mycosis fungoides, business.industry, Lymphoma, Non-Hodgkin, Australia, Waldenstrom macroglobulinemia, General Medicine, Middle Aged, medicine.disease, Non-Hodgkin's lymphoma, Europe, Case-Control Studies, Epidemiologic Research Design, North America, Immunology, International Lymphoma Epidemiology Consortium, hematologic malignancy, Female, Mantle cell lymphoma, business
Abstract

Background: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design. Methods: We pooled individual-level data from 20 case-control studies (17 471 NHL cases, 23 096 controls) from North America, Europe, and Australia. Centralized data harmonization and analysis ensured standardized definitions and approaches, with rigorous quality control. Results: The pooled study population included 11 specified NHL subtypes with more than 100 cases: diffuse large B-cell lymphoma (N = 4667), follicular lymphoma (N = 3530), chronic lymphocytic leukemia/small lymphocytic lymphoma (N = 2440), marginal zone lymphoma (N = 1052), peripheral T-cell lymphoma (N = 584), mantle cell lymphoma (N = 557), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (N = 374), mycosis fungoides/Sézary syndrome (N = 324), Burkitt/Burkitt-like lymphoma/leukemia (N = 295), hairy cell leukemia (N = 154), and acute lymphoblastic leukemia/lymphoma (N = 152). Associations with medical history, family history, lifestyle factors, and occupation for each of these 11 subtypes are presented in separate articles in this issue, with a final article quantitatively comparing risk factor patterns among subtypes. Conclusions: The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date. The analyses contribute to our understanding of the multifactorial nature of NHL subtype etiologies, motivate hypothesis-driven prospective investigations, provide clues for prevention, and exemplify the benefits of international consortial collaboration in cancer epidemiology.

Published
2014

93. Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Author

Paige M. Bracci, Thomas M. Habermann, Kenneth P. Cantor, Stefania Rodella, John J. Spinelli, Brenda M. Birmann, Paul Brennan, Alain Monnereau, Christina A. Clarke, Eva Negri, Susan L. Slager, Elizabeth A. Holly, Patricia Hartge, Silvia Franceschi, Sonja I. Berndt, Silvia de Sanjosé, Paolo Vineis, Qing Lan, Anneclaire J. De Roos, Paolo Crosignani, Jennifer Turner, Randy D. Gascoyne, Joanne S. Colt, Eve Roman, Richard K. Severson, Alexandra M. Levine, Emanuele Stagnaro, Bengt Glimelius, Marc Maynadié, Jonathan W. Friedberg, Yawei Zhang, Theodore R. Holford, Angela Brooks-Wilson, Oriana Nanni, Dennis D. Weisenburger, Joshua N. Sampson, Nathaniel Rothman, Yolanda Benavente, Andrew L. Feldman, Leslie Bernstein, Pierluigi Cocco, Marshall E. Kadin, Luigino Dal Maso, Valerio Ramazzotti, Lenka Foretova, Lucia Miligi, Sophia S. Wang, Rosario Tumino, Hans-Olov Adami, Wendy Cozen, Tracy Lightfoot, Sam M. Mbulaiteye, Jacqueline Clavel, Tongzhang Zheng, Paolo Boffetta, Anne Kricker, Martha S. Linet, Alexandra Nieters, Christine F. Skibola, Claire M. Vajdic, Nikolaus Becker, Laurent Orsi, Eleanor Kane, Diego Serraino, Carlo La Vecchia, Alex Smith, James M. Foran, Lindsay M. Morton, Anthony Staines, Simonetta Di Lollo, Mads Melbye, Jennifer L. Kelly, James R. Cerhan, Timothy G. Call, Henrik Hjalgrim, Christopher R. Flowers, Bruce K. Armstrong, Joseph M. Connors, Mark Liebow, Ora Paltiel, Ellen T. Chang, Aaron Blair, Karin E. Smedby, Carla Vindigni, Brian C.-H. Chiu, Adele Seniori Costantini, Scott Davis, Morton, L.M., Slager, S.L., Cerhan, J.R., Wang, S.S., Vajdic, C.M., Skibola, C.F., Bracci, P.M., de Sanjosé, S., Smedby, K.E., Chiu, B.C.H., Zhang, Y., Mbulaiteye, S.M., Monnereau, A., Turner, J.J., Clavel, J., Adami, H.-O., Chang, E.T., Glimelius, B., Hjalgrim, H., Melbye, M., Crosignani, P., di Lollo, S., Miligi, L., Nanni, O., Ramazzotti, V., Rodella, S., Costantini, A.S., Stagnaro, E., Tumino, R., Vindigni, C., Vineis, P., Becker, N., Benavente, Y., Boffetta, P., Brennan, P., Cocco, P., Foretova, L., Maynadié, M., Nieters, A., Staines, A., Colt, J.S., Cozen, W., Davis, S., de Roos, A.J., Hartge, P., Rothman, N., Severson, R.K., Holly, E.A., Call, T.G., Feldman, A.L., Habermann, T.M., Liebow, M., Blair, A., Cantor, K.P., Kane, E.V., Lightfoot, T., Roman, E., Smith, A., Brooks-Wilson, A., Connors, J.M., Gascoyne, R.D., Spinelli, J.J., Armstrong, B.K., Kricker, A., Holford, T.R., Lan, Q., Zheng, T., Orsi, L., Dal Maso, L., Franceschi, S., La Vecchia, C., Negri, E., Serraino, D., Bernstein, L., Levine, A., Friedberg, J.W., Kelly, J.L., Berndt, S.I., Birmann, B.M., Clarke, C.A., Flowers, C.R., Foran, J.M., Kadin, M.E., Paltiel, O., Weisenburger, D.D., Linet, M.S., and Sampson, J.N.

Subjects
Adult, Male, Cancer Research, Adolescent, Chronic lymphocytic leukemia, Follicular lymphoma, Comorbidity, Disease, Non-Hodgkin lymphoma (NHL), Article, Young Adult, Risk Factors, immune system diseases, Occupational Exposure, hemic and lymphatic diseases, Odds Ratio, medicine, Cluster Analysis, Humans, Risk factor, Family history, Life Style, Aged, Aged, 80 and over, International Lymphoma Epidemiology Consortium (InterLymph), business.industry, Lymphoma, Non-Hodgkin, Australia, Case-control study, General Medicine, Odds ratio, Middle Aged, medicine.disease, Lymphoma, Europe, Oncology, Case-Control Studies, North America, Immunology, Female, business
Abstract

Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the fifth most common type of cancer in more developed regions of the world (1). Numerous NHL subtypes with distinct combinations of morphologic, immunophenotypic, genetic, and clinical features are currently recognized (2,3). The incidence of NHL subtypes varies substantially by age, sex, and race/ethnicity (4–7). However, the etiological implications of this biological, clinical, and epidemiological diversity are incompletely understood. The importance of investigating etiology by NHL subtype is clearly supported by research on immunosuppression, infections, and autoimmune diseases, which are the strongest and most established risk factors for NHL. Studies of solid organ transplant recipients and individuals infected with HIV demonstrate that risks are markedly increased for several—but not all—NHL subtypes (8–13). Some infections and autoimmune diseases are associated with a single specific subtype [eg, human T-cell lymphotropic virus, type I (HTLV-I) with adult T-cell leukemia/lymphoma (14), celiac disease with enteropathy-type peripheral T-cell lymphoma (PTCL) (15–17)], whereas others [eg, Epstein–Barr virus, hepatitis C virus (HCV), Sjogren’s syndrome (18–21)] have been associated with multiple subtypes. In the last two decades, reports from individual epidemiological studies of NHL have suggested differences in risks among NHL subtypes for a wide range of risk factors, but most studies have lacked the statistical power to assess any differences quantitatively and have not systematically evaluated combinations of subtypes. One study assessed multiple risk factors and found support for both etiologic commonality and heterogeneity for NHL subtypes, with risk factor patterns suggesting that immune dysfunction is of greater etiologic importance for diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphoma than for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (22). However, that analysis was limited to approximately 1300 NHL cases and considered only the four most common NHL subtypes. Pooling data from multiple studies through the International Lymphoma Epidemiology Consortium (InterLymph) have provided substantial insight into associations between specific risk factors and NHL subtypes, with evidence that family history of hematologic malignancy, autoimmune diseases, atopic conditions, lifestyle factors (smoking, alcohol, anthropometric measures, and hair dye use), and sun exposure are associated with NHL risk (19,21,23–32). However, no previous study has compared patterns of risk for a range of exposures for both common and rarer NHL subtypes. We undertook the InterLymph NHL Subtypes Project, a pooled analysis of 20 case–control studies including 17 471 NHL cases and 23 096 controls, to advance understanding of NHL etiology by investigating NHL subtype-specific risks associated with medical history, family history of hematologic malignancy, lifestyle factors, and occupation. The detailed risk factor profiles for each of 11 NHL subtypes appear in this issue (15–17,33–40). In this report, we assess risk factor heterogeneity among the NHL subtypes and identify subtypes that have similar risk factor profiles.

Published
2014

94. Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region

Author

Joseph Vijai, W. Ryan Diver, Degui Zhi, Brenda M. Birmann, Henrik Hjalgrim, Bruce K. Armstrong, Gianluca Severi, Pierluigi Cocco, Joseph F. Fraumeni, Xifeng Wu, Graham G. Giles, Eleanor Kane, Herve Ghesquieres, Eve Roman, Edward Giovannucci, Mads Melbye, Rudolph Kaaks, Lindsay M. Morton, Nicholas K. Akers, Elizabeth A. Holly, Liming Liang, Patrizio Mazza, Kari E. North, John J. Spinelli, Carrie A. Thompson, Bodil Ohlsson, Yuanqing Ye, Anneclaire J. De Roos, Stephen J. Chanock, Theodore R. Holford, Paul Brennan, Jianjun Liu, Roel Vermeulen, Thomas E. Witzig, Angela Brooks-Wilson, Mark P. Purdue, Ahmet Dogan, Gilles Salles, Kenneth Offit, Lucia Conde, Laurie Burdett, George J. Weiner, Anne Kricker, James McKay, Peter Kraft, Sonja I. Berndt, Attilio Gabbas, Rebecca Montalvan, Rebecca D. Jackson, Baoshan Ma, Zhaoming Wang, Patricia Hartge, Danylo J. Villano, Marc Maynadie, Mortimer J. Lacher, Lauren R. Teras, Susan L. Slager, Lenka Foretova, Rachel S. Kelly, Martha S. Linet, Brian K. Link, Jarmo Virtamo, Charles C. Chung, Anne Zeleniuch-Jacquotte, Martyn T. Smith, Tracy Lightfoot, Jacques Riby, Paolo Boffetta, Meredith Yeager, Brian C.-H. Chiu, Grzegorz S. Nowakowski, Yolanda Benavente, Bengt Glimelius, Mark Liebow, Saioa Chamosa, Charles E. Lawrence, Karin E. Smedby, Nikolaus Becker, Thomas M. Habermann, Jacqueline Clavel, Qing Lan, Alexandra Nieters, Maryjean Schenk, Sophia S. Wang, Demetrius Albanes, Lesley F. Tinker, Alex Smith, Anthony Staines, Amy Hutchinson, Wendy Cozen, Hans-Olov Adami, Anne J. Novak, Christine F. Skibola, Ann Maria, Elisabete Weiderpass, Kimberly A. Bertrand, James R. Cerhan, Maria Grazia Ennas, Claire M. Vajdic, Jinyan Huang, Paul I.W. de Bakker, Paige M. Bracci, Tongzhang Zheng, Ruth C. Travis, Paolo Vineis, Jia Nee Foo, Jennifer Turner, Alain Monnereau, Silvia de Sanjosé, Nathaniel Rothman, Yawei Zhang, Jian Gu, Skibola, C.F., Berndt, S.I., Vijai, J., Conde, L., Wang, Z., Yeager, M., De Bakker, P.I.W., Birmann, B.M., Vajdic, C.M., Foo, J.-N., Bracci, P.M., Vermeulen, R.C.H., Slager, S.L., De Sanjose, S., Wang, S.S., Linet, M.S., Salles, G., Lan, Q., Severi, G., Hjalgrim, H., Lightfoot, T., Melbye, M., Gu, J., Ghesquières, H., Link, B.K., Morton, L.M., Holly, E.A., Smith, A., Tinker, L.F., Teras, L.R., Kricker, A., Becker, N., Purdue, M.P., Spinelli, J.J., Zhang, Y., Giles, G.G., Vineis, P., Monnereau, A., Bertrand, K.A., Albanes, D., Zeleniuch-Jacquotte, A., Gabbas, A., Chung, C.C., Burdett, L., Hutchinson, A., Lawrence, C., Montalvan, R., Liang, L., Huang, J., Ma, B., Liu, J., Adami, H.-O., Glimelius, B., Ye, Y., Nowakowski, G.S., Dogan, A., Thompson, C.A., Habermann, T.M., Novak, A.J., Liebow, M., Witzig, T.E., Weiner, G.J., Schenk, M., Hartge, P., De Roos, A.J., Cozen, W., Zhi, D., Akers, N.K., Riby, J., Smith, M.T., Lacher, M., Villano, D.J., Maria, A., Roman, E., Kane, E., Jackson, R.D., North, K.E., Diver, W.R., Turner, J., Armstrong, B.K., Benavente, Y., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., Staines, A., McKay, J., Brooks-Wilson, A.R., Zheng, T., Holford, T.R., Chamosa, S., Kaaks, R., Kelly, R.S., Ohlsson, B., Travis, R.C., Weiderpass, E., Clavel, J., Giovannucci, E., Kraft, P., Virtamo, J., Mazza, P., Cocco, P., Ennas, M.G., Chiu, B.C.H., Fraumeni, J.F., Jr., Nieters, A., Offit, K., Wu, X., Cerhan, J.R., Smedby, K.E., Chanock, S.J., and Rothman, N.

Subjects
EXPRESSION, Follicular lymphoma, Single-nucleotide polymorphism, Genome-wide association study, Human leukocyte antigen, Biology, VARIANTS, Polymorphism, Single Nucleotide, follicular lymphoma, HLA Antigens, Polymorphism (computer science), Report, CLASS-I, RESOURCE, Biomarkers, Tumor, Genetics, medicine, Chromosomes, Human, Humans, TOOL, Genetic Predisposition to Disease, Genetics(clinical), PEPTIDE, Allele, Lymphoma, Follicular, Alleles, Genetics (clinical), Genetic association, SNPS, RISK, Genome-wide association, Haplotype, medicine.disease, HLA, Haplotypes, Case-Control Studies, UNIVERSITY, SET, Genome-Wide Association Study
Abstract

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10 -20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10 -11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10 -10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10 -10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10 -8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRß1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10 -67 to 2.67 × 10 -70). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10 -16) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10 -9). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. © 2014 by The American Society of Human Genetics. All rights reserved.

Published
2016

95. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

Author

Henrik Hjalgrim, Joseph Vijai, Bengt Glimelius, Kimberly A. Bertrand, Immaculata De Vivo, Eve Roman, Martha Glenn, Nathaniel Rothman, Yolanda Benavente, Zhaoming Wang, Ju-Hyun Park, Anneclaire J. De Roos, John J. Spinelli, Demetrius Albanes, Paul Brennan, Emanuele Angelucci, Mariagrazia Zucca, Qing Lan, Kari E. North, Paige M. Bracci, Mark P. Purdue, Marco Rais, Melissa C. Southey, Alain Monnereau, Ahmet Dogan, Graham G. Giles, Robert J. Klein, Peter Kraft, Lesley F. Tinker, Laurie Burdett, Lucia Conde, Carrie A. Thompson, James McKay, Martyn T. Smith, Göran Roos, Yan W. Asmann, Dennis D. Weisenburger, Elizabeth A. Holly, Thomas E. Witzig, Liming Liang, Paul I.W. de Bakker, Alex Smith, Jarmo Virtamo, Charles E. Lawrence, Patricia Hartge, Karen Curtin, Anthony Staines, Nikolaus Becker, Nicola J. Camp, Charles C. Chung, Degui Zhi, Brenda M. Birmann, W. Ryan Diver, Roel Vermeulen, Sonja I. Berndt, Tongzhang Zheng, Silvia de Sanjosé, Eleanor Kane, James R. Cerhan, Christopher R. Flowers, Joseph F. Fraumeni, Stephen J. Chanock, Stephen M. Ansell, Angela Brooks-Wilson, Kenneth Offit, Jinyan Huang, Mads Melbye, Edward Giovannucci, Baoshan Ma, Tracy Lightfoot, Brian K. Link, Richard K. Severson, Theodore R. Holford, Yawei Zhang, Anne Tjønneland, Meredith Yeager, Wendy Cozen, Anne J. Novak, Lauren R. Teras, Claire M. Vajdic, Lisa A. Cannon-Albright, Lenka Foretova, Christine F. Skibola, Sophia S. Wang, Hans-Olov Adami, Andrew D. Zelenetz, Jenny Turner, Paolo Vineis, Corinne Haioun, Hervé Tilly, Anne Zeleniuch-Jacquotte, Thomas M. Habermann, Paolo Boffetta, Jacqueline Clavel, Herve Ghesquieres, Stephanie J. Weinstein, Lindsay M. Morton, Susan L. Slager, Simon Crouch, Gilles Salles, Rachel S. Kelly, Karin E. Smedby, Amy Hutchinson, David G. Cox, Elio Riboli, Jacques Riby, Rebecca D. Jackson, Mark Liebow, Thierry Jo Molina, Danylo J. Villano, Marc Maynadie, Yuanqing Ye, Heiner Boeing, Jian Gu, Brian C.-H. Chiu, Simonetta Di Lollo, Mitchell J. Machiela, Alexandra Nieters, Xifeng Wu, Rudolph Kaaks, Machiela, M.J., Lan, Q., Slager, S.L., Vermeulen, R.C.H., Teras, L.R., Camp, N.J., Cerhan, J.R., Spinelli, J.J., Wang, S.S., Nieters, A., Vijai, J., Yeager, M., Wang, Z., Ghesquières, H., McKay, J., Conde, L., de Bakker, P.I.W., Cox, D.G., Burdett, L., Monnereau, A., Flowers, C.R., De Roos, A.J., Brooks-Wilson, A.R., Giles, G.G., Melbye, M., Gu, J., Jackson, R.D., Kane, E., Purdue, M.P., Vajdic, C.M., Albanes, D., Kelly, R.S., Zucca, M., Bertrand, K.A., Zeleniuch-Jacquotte, A., Lawrence, C., Hutchinson, A., Zhi, D., Habermann, T.M., Link, B.K., Novak, A.J., Dogan, A., Asmann, Y.W., Liebow, M., Thompson, C.A., Ansell, S.M., Witzig, T.E., Tilly, H., Haioun, C., Molina, T.J., Hjalgrim, H., Glimelius, B., Adami, H.-O., Roos, G., Bracci, P.M., Riby, J., Smith, M.T., Holly, E.A., Cozen, W., Hartge, P., Morton, L.M., Severson, R.K., Tinker, L.F., North, K.E., Becker, N., Benavente, Y., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., Staines, A., Lightfoot, T., Crouch, S., Smith, A., Roman, E., Ryan Diver, W., Offit, K., Zelenetz, A., Klein, R.J., Villano, D.J., Zheng, T., Zhang, Y., Holford, T.R., Turner, J., Southey, M.C., Clavel, J., Virtamo, J., Weinstein, S., Riboli, E., Vineis, P., Kaaks, R., Boeing, H., Tjønneland, A., Angelucci, E., Di Lollo, S., Rais, M., De Vivo, I., Giovannucci, E., Kraft, P., Huang, J., Ma, B., Ye, Y., Chiu, B.C.H., Liang, L., Park, J.-H., Chung, C.C., Weisenburger, D.D., Fraumeni, J.F., Jr and Salles, G., Glenn, M., Cannon-Albright, L., Curtin, K., Wu, X., Smedby, K.E., de Sanjose, S., Skibola, C.F., Berndt, S.I., Birmann, B.M., Chanock, S.J., Rothman, N., LS IRAS EEPI GRA (Gezh.risico-analyse), Sub Atmospheric physics and chemistry, dIRAS RA-I&I RA, dIRAS RA-2, Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Cancer environnement ( EPICENE ), Bordeaux population health ( BPH ), Université de Bordeaux ( UB ) -Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bordeaux ( UB ) -Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Registre des hémopathies malignes de la Gironde, Institut Bergonié - CRLCC Bordeaux, Department of Agronomy, University of Wisconsin-Madison [Madison], Service hématologie Poitiers, CHU, Service d'hématologie clinique, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Université Paris Descartes - Paris 5 ( UPD5 ), Oslo and Akershus University College ( OAUC ), Laboratoire de mécanique Biomécanique Polymère Structures ( LaBPS ), Université de Lorraine ( UL ), The Tisch Cancer Institute, Mount Sinai School of Medicine, International Agency for Cancer Research ( IACR ), International Agency for Cancer Research, Registre des hémopathies malignes de Côte d'Or, Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), University of Chicago Medicine, Institut National de la Santé et de la Recherche Médicale ( INSERM ), French National Registry of Childhood Hematological malignancies (NRCH), NRCH, Division of Epidemiology, Public Health and Primary Care, Imperial College London, Unit of Cancer Epidemiology, AOU S. Giovanni Battista, CPO Piemonte, CeRMS, University of Torino, Department of Epidemiology and Public Health, Department Cancer Epidemiology, German Cancer Research Center, Institute of Human Nutrition Potsdam-Rehbruecke, Diet, Cancer and Health, Danish Cancer Society, Justus Liebig University Giessen, Sino French Research Center for Biomedical Imaging ( HIT-INSA ), Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Harbin Institute of Technology ( HIT ), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Beijing] ( CAS ), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, University of Wisconsin-Madison, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris Descartes - Paris 5 (UPD5), Akershus University College, Laboratoire de mécanique Biomécanique Polymère Structures (LaBPS), Université de Lorraine (UL), Icahn School of Medicine at Mount Sinai [New York] (MSSM), International Agency for Cancer Research (IACR), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), Institut National de la Santé et de la Recherche Médicale (INSERM), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Justus-Liebig-Universität Gießen (JLU), Sino French Research Center for Biomedical Imaging (HIT-INSA), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Harbin Institute of Technology (HIT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chinese Academy of Sciences [Beijing] (CAS), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Harbin Institute of Technology (HIT), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (CRCL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Oslo and Akershus University College (OAUC), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
0301 basic medicine, Serum, Male, Lymphoma, analysis, Chronic lymphocytic leukemia, Follicular lymphoma, Global Health, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, immunology, surgery, 0302 clinical medicine, Endocrinology, immune system diseases, single nucleotide polymorphism, Germany, hemic and lymphatic diseases, London, 80 and over, Odds Ratio, genetics, Prospective Studies, B-cell lymphoma, Association Studies Article, Genetics (clinical), Aged, 80 and over, education.field_of_study, telomere, Genome, Leukemia, Age Factors, General Medicine, Environmental exposure, Genomics, Middle Aged, b-cell lymphoma, small cell lymphoma, Italy, 030220 oncology & carcinogenesis, Medicine, epidemiology, Female, France, Risk of B-cell lymphoma subtypes, Risk, Adult, Canada, China, Lymphoma, B-Cell, Genotype, Adolescent, leukocytes, etiology, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Environment, Risk Assessment, methods, Time, 03 medical and health sciences, medicine, Humans, Family, Genetic Predisposition to Disease, education, Molecular Biology, Alleles, Occupational Health, Genetic Association Studies, Aged, B-Cell, International Agencies, Odds ratio, Environmental Exposure, medicine.disease, Telomere, Non-Hodgkin's lymphoma, 030104 developmental biology, Immunology, physiology, Chronic Disease, pathology, Laboratories, metabolism
Abstract

International audience; Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk

Published
2016

96. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Author

Nathaniel Rothman, Yolanda Benavente, Paul Brennan, Qing Lan, Pierluigi Cocco, Simon Crouch, Anneclaire J. De Roos, Josh Wright, Christine F. Skibola, Mark P. Purdue, Elisabete Weiderpass, James R. Cerhan, Randy D. Gascoyne, Maria Grazia Ennas, Kari E. North, Zhaoming Wang, Jinyan Huang, Julie M. Cunningham, Alain Monnereau, Peter Kraft, Patricia Hartge, Edward Giovannucci, Karen Curtin, Giovanna Masala, Jacqueline Clavel, Neil E. Kay, Jacques Riby, María Dolores Chirlaque, John J. Spinelli, Delphine Casabonne, Jenny Turner, Lucia Conde, Lesley F. Tinker, Martha Glenn, Sara S. Strom, Donna K. Arnett, Rebecca Montalvan, Ju-Hyun Park, Melissa C. Southey, Ann Maria, Karin E. Smedby, Lindsay M. Morton, Marc Maynadié, Laurie Burdett, Amy Hutchinson, Bengt Glimelius, W. Ryan Diver, Elio Riboli, Sonja I. Berndt, Lisa A. Cannon-Albright, Kimberly A. Bertrand, Aaron D. Norman, Sara J. Achenbach, Celine M. Vachon, Angela Cox, Xifeng Wu, Theodore R. Holford, Neil E. Caporaso, Joseph F. Fraumeni, Roel Vermeulen, Rudolph Kaaks, Mads Melbye, Joseph Vijai, Kari G. Chaffee, Lauren R. Teras, Rebecca D. Jackson, Lenka Foretova, J. Brice Weinberg, Paige M. Bracci, Sophia S. Wang, Demetrius Albanes, Stephen J. Chanock, Wendy Cozen, Mark Liebow, Anne J. Novak, Hans-Olov Adami, George J. Weiner, Angela Brooks-Wilson, Kenneth Offit, Anne Kricker, Claire M. Vajdic, James McKay, Ellen T. Chang, Baoshan Ma, Cristine Allmer, Susan L. Slager, Brian K. Link, Elizabeth A. Holly, Anthony Staines, Liming Liang, Jarmo Virtamo, Timothy G. Call, Nicola J. Camp, Ruth C. Travis, Alexandra Nieters, Degui Zhi, Brenda M. Birmann, Tait D. Shanafelt, Rachel S. Kelly, Graham G. Giles, Nilanjan Chatterjee, John A. Snowden, Yuanqing Ye, Núria Sala, Tongzhang Zheng, Paolo Boffetta, Lynn R. Goldin, Danylo J. Villano, Jose F. Leis, Paolo Vineis, Lucia Miligi, Jian Gu, Justin M. Leach, Silvia de Sanjosé, Richard K. Severson, Yawei Zhang, Henrik Hjalgrim, Roger L. Milne, Charles E. Lawrence, Meredith Yeager, Moara Machado, Nikolaus Becker, Joseph M. Connors, Anne Zeleniuch-Jacquotte, Giovanni Maria Ferri, Stephanie J. Weinstein, LS IRAS EEPI GRA (Gezh.risico-analyse), Sub Atmospheric physics and chemistry, dIRAS RA-I&I RA, dIRAS RA-2, Berndt, S.I., Camp, N.J., Skibola, C.F., Vijai, J., Wang, Z., Gu, J., Nieters, A., Kelly, R.S., Smedby, K.E., Monnereau, A., Cozen, W., Cox, A., Wang, S.S., Lan, Q., Teras, L.R., Machado, M., Yeager, M., Brooks-Wilson, A.R., Hartge, P., Purdue, M.P., Birmann, B.M., Vajdic, C.M., Cocco, P., Zhang, Y., Giles, G.G., Zeleniuch-Jacquotte, A., Lawrence, C., Montalvan, R., Burdett, L., Hutchinson, A., Ye, Y., Call, T.G., Shanafelt, T.D., Novak, A.J., Kay, N.E., Liebow, M., Cunningham, J.M., Allmer, C., Hjalgrim, H., Adami, H.-O., Melbye, M., Glimelius, B., Chang, E.T., Glenn, M., Curtin, K., Cannon-Albright, L.A., Diver, W.R., Link, B.K., Weiner, G.J., Conde, L., Bracci, P.M., Riby, J., Arnett, D.K., Zhi, D., Leach, J.M., Holly, E.A., Jackson, R.D., Tinker, L.F., Benavente, Y., Sala, N., Casabonne, D., Becker, N., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., McKay, J., Staines, A., Chaffee, K.G., Achenbach, S.J., Vachon, C.M., Goldin, L.R., Strom, S.S., Leis, J.F., Weinberg, J.B., Caporaso, N.E., Norman, A.D., De Roos, A.J., Morton, L.M., Severson, R.K., Riboli, E., Vineis, P., Kaaks, R., Masala, G., Weiderpass, E., Chirlaque, M.-D., Vermeulen, R.C.H., Travis, R.C., Southey, M.C., Milne, R.L., Albanes, D., Virtamo, J., Weinstein, S., Clavel, J., Zheng, T., Holford, T.R., Villano, D.J., Maria, A., Spinelli, J.J., Gascoyne, R.D., Connors, J.M., Bertrand, K.A., Giovannucci, E., Kraft, P., Kricker, A., Turner, J., Ennas, M.G., Ferri, G.M., Miligi, L., Liang, L., Ma, B., Huang, J., Crouch, S., Park, J.-H., Chatterjee, N., North, K.E., Snowden, J.A., Wright, J., Fraumeni, J.F., Offit, K., Wu, X., De Sanjose, S., Cerhan, J.R., Chanock, S.J., Rothman, N., Slager, S.L., National Cancer Institute ( NIH ), Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Registre des hémopathies malignes de Côte d'Or, Mayo Clinic [Rochester], National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), and UNICANCER-UNICANCER

Subjects
0301 basic medicine, Medicin och hälsovetenskap, Chronic lymphocytic leukemia, General Physics and Astronomy, Genome-wide association study, VARIANTS, Medical and Health Sciences, Malalties hereditàries, [ SDV.MHEP.HEM ] Life Sciences [q-bio]/Human health and pathology/Hematology, Chronic, Genetics, RISK, Leukemia, Multidisciplinary, BANK1, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, Bcl-2-Like Protein 11, Adaptor Proteins, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Single Nucleotide, Lymphocytic, 3. Good health, PRIORITIZATION, Multidisciplinary Sciences, medicine.anatomical_structure, Science & Technology - Other Topics, TRANSCRIPTION FACTOR EOMESODERMIN, Genetic disorders, EXPRESSION, SUSCEPTIBILITY LOCI, Science, European Continental Ancestry Group, FAS GENE-MUTATIONS, Locus (genetics), Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, CLASSIFICATION, White People, Article, 03 medical and health sciences, Proto-Oncogene Proteins, MD Multidisciplinary, medicine, Genetic predisposition, SNP, Humans, Leucèmia limfocítica crònica, Genetic Predisposition to Disease, Polymorphism, B cell, Serpins, Genetic association, Adaptor Proteins, Signal Transducing, Science & Technology, Signal Transducing, B-Cell, Membrane Proteins, General Chemistry, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, 030104 developmental biology, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, Apoptosis Regulatory Proteins, T-Box Domain Proteins, FOLLICULAR LYMPHOMA, Genome-Wide Association Study
Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P, Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPP associated with risk of this disease.

Published
2016

97. PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Danica R. Skibola, Lenka Foretova, Lindsay M. Morton, James R. Cerhan, Sophia S. Wang, John J. Spinelli, Eran Halperin, Stephen J. Chanock, Stephen M. Ansell, Paul Brennan, Luz Agana, Mark P. Purdue, Alexandra Nieters, Anne Kricker, Alice H. Wang, Marc Maynadié, Silvia de Sanjosé, Paige M. Bracci, Lucia Conde, Katja Butterbach, Richard K. Severson, Yawei Zhang, Jacques Riby, Anneclaire J. De Roos, Christine F. Skibola, Patricia Hartge, Wendy Cozen, Anne J. Novak, Claire M. Vajdic, Qing Lan, Susan L. Slager, Nathaniel Rothman, Yolanda Benavente, Nikolaus Becker, Anthony Staines, Pierluigi Cocco, Tait D. Shanafelt, Andrew E. Grulich, Bruce K. Armstrong, Tongzhang Zheng, Paolo Boffetta, Martyn T. Smith, Angela Brooks-Wilson, Nieters, A., Conde, L., Slager, S.L., Brooks-Wilson, A., Morton, L., Skibola, D.R., Novak, A.J., Riby, J., Ansell, S.M., Halperin, E., Shanafelt, T.D., Agana, L., Wang, A.H., De Roos, A.J., Severson, R.K., Cozen, W., Spinelli, J., Butterbach, K., Becker, N., De Sanjose, S., Benavente, Y., Cocco, P., Staines, A., Maynadié, M., Foretova, L., Boffetta, P., Brennan, P., Lan, Q., Zhang, Y., Zheng, T., Purdue, M., Armstrong, B., Kricker, A., Vajdic, C.M., Grulich, A., Smith, M.T., Bracci, P.M., Chanock, S.J., Hartge, P., Cerhan, J.R., Wang, S.S., Rothman, N., and Skibola, C.F.

Subjects
Male, Genotype, Immunology, Follicular lymphoma, Single-nucleotide polymorphism, Genome-wide association study, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Biochemistry, PRRC2A, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Meta-Analysis as Topic, Risk Factors, immune system diseases, Proto-Oncogene Proteins, hemic and lymphatic diseases, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, Genotyping, Non-Hodgkin lymphoma, InterLymph consortium, 030304 developmental biology, 0303 health sciences, Lymphoid Neoplasia, Bcl-2-Like Protein 11, Lymphoma, Non-Hodgkin, Case-control study, Membrane Proteins, Proteins, Cell Biology, Hematology, Odds ratio, medicine.disease, 3. Good health, Lymphoma, BCL2L11, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Apoptosis Regulatory Proteins
Abstract

Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 × 10−11), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 × 10−9) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.

Published
2012

98. Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study

Author

Paul Brennan, Lucia Miligi, Mariagrazia Zucca, Pierluigi Cocco, Marc Maynadié, Claudia Pili, Andrea Martine 't Mannetje, Silvia de Sanjosé, Giannina Satta, Paolo Boffetta, Yolanda Benavente, Anthony Staines, Nikolaus Becker, Alexandra Nieters, M Pilleri, Maria Grazia Ennas, S Dubois, Lenka Foretova, Cocco, P., Satta, G., Dubois, S., Pili, C., Pilleri, M., Zucca, M., Mannetje, A.M., Becker, N., Benavente, Y., De Sanjosé, S., Foretova, L., Staines, A., Maynadié, M., Nieters, A., Brennan, P., Miligi, L., Ennas, M.G., and Boffetta, P.

Subjects
Adult, Male, medicine.medical_specialty, Lymphoma, B-Cell, case-control study, lymphoma, Logistic regression, Toxicology, agrochemical, Risk Factors, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Pesticides, B-cell lymphoma, business.industry, Public Health, Environmental and Occupational Health, Case-control study, occupational exposure, Pesticide, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Europe, Leukemia, Case-Control Studies, Etiology, Female, Occupational exposure, business
Abstract

Objectives We investigated the role of occupational exposure to specific groups of agrochemicals in the aetiology of lymphoma overall, B cell lymphoma and its most prevalent subtypes. Methods In 1998–2003, 2348 incident lymphoma cases and 2462 controls were recruited to the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Job modules were applied for farm work including specific questions on type of crop, farm size, pests being treated, type and schedule of pesticide use. In each study centre, industrial hygienists and occupational experts assessed exposure to specific groups of pesticides and individual compounds with the aid of agronomists. We calculated the OR and its 95% CI associated with lymphoma and the most prevalent lymphoma subtypes with unconditional logistic regression, adjusting for age, gender, education and centre. Results Risk of lymphoma overall, and B cell lymphoma was not elevated, and risk of chronic lymphocytic leukaemia (CLL) was elevated amongst those ever exposed to inorganic (OR=1.6, 95% CI 1.0 to 2.5) and organic pesticides (OR=1.5, 95% CI 1.0 to 2.1). CLL risk was highest amongst those ever exposed to organophosphates (OR=2.7, 95% CI 1.2 to 6.0). Restricting the analysis to subjects most likely exposed, no association was observed between pesticide use and risk of B cell lymphoma. Conclusions Our results provide limited support to the hypothesis of an increase in risk of specific lymphoma subtypes associated with exposure to pesticides.

Published
2012

99. Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium

Author

Renato Talamini, John J. Spinelli, Yolanda Benavente, Marc Maynadié, Alexandra Nieters, Andrew E. Grulich, Paul Brennan, James R. Cerhan, Anthony Staines, Pierluigi Cocco, Silvia Franceschi, Wendy Cozen, Lenka Foretova, Nikolaus Becker, Patricia Hartge, Ramon Bosch, Claire M. Vajdic, Elizabeth A. Holly, Lindsay M. Morton, Paige M. Bracci, Silvia de Sanjosé, Eric A. Engels, Yawei Zhang, Tongzhang Zheng, Paolo Boffetta, De Sanjose, S., Benavente, Y., Vajdic, C.M., Engels, E.A., Morton, L.M., Bracci, P.M., Spinelli, J.J., Zheng, T., Zhang, Y., Franceschi, S., Talamini, R., Holly, E.A., Grulich, A.E., Cerhan, J.R., Hartge, P., Cozen, W., Boffetta, P., Brennan, P., Maynadié, M., Cocco, P., Bosch, R., Foretova, L., Staines, A., Becker, N., and Nieters, A.

Subjects
Adult, Male, Risk, medicine.medical_specialty, Lymphoma, B-Cell, Adolescent, Non-Hodgkin Lymphoma, Hepatitis C virus, Follicular lymphoma, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Gastroenterology, Article, Lymphoplasmacytic Lymphoma, immune system diseases, hemic and lymphatic diseases, Internal medicine, Epidemiology, Prevalence, medicine, Humans, Sex Distribution, Aged, Aged, 80 and over, Hepatology, business.industry, Racial Groups, Australia, Hepatitis C, Odds ratio, Middle Aged, medicine.disease, United States, Malaltia de Hodgkin, Lymphoma, Europe, Logistic Models, Case-Control Studies, Immunology, Female, Hodgkin's disease, business, Diffuse large B-cell lymphoma
Abstract

Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma). © 2008 AGA Institute.

Published
2008

100. Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

Author

Silvia de Sanjosé, Scott Davis, Patricia Hartge, Wendy Cozen, Ora Paltiel, Richard K. Severson, Anne Kricker, Lindsay M. Morton, Yawei Zhang, Pierluigi Cocco, Henrik Hjalgrim, Dennis D. Weisenburger, Anneclaire J. De Roos, Martha S. Linet, Qing Lan, Claire M. Vajdic, Elizabeth A. Holly, James R. Cerhan, Karin E. Smedby, John J. Spinelli, Tracy Lightfoot, Alexandra Nieters, Otoniel Martinez-Maza, Tongzhang Zheng, Elizabeth C. Breen, Christopher R. Flowers, Elizabeth E. Brown, Eve Roman, Marc Maynadié, Graciela S. Alarcón, Stephen J. Chanock, Nikolaus Becker, Nathaniel Rothman, Jennifer Turner, Yolanda Benavente, Christine F. Skibola, Paige M. Bracci, Anthony Staines, Eleanor Kane, Jenna M. Voutsinas, Paolo Boffetta, Martyn T. Smith, Lenka Foretova, Sophia S. Wang, Susan L. Slager, Brenda M. Birmann, Angela Brooks-Wilson, Wang, S.S., Vajdic, C.M., Linet, M.S., Slager, S.L., Voutsinas, J., Nieters, A., De Sanjose, S., Cozen, W., Alarcón, G.S., Martinez-Maza, O., Brown, E.E., Bracci, P.M., Lightfoot, T., Turner, J., Hjalgrim, H., Spinelli, J.J., Zheng, T., Morton, L.M., Birmann, B.M., Flowers, C.R., Paltiel, O., Becker, N., Holly, E.A., Kane, E., Weisenburger, D., Maynadie, M., Cocco, P., Foretova, L., Staines, A., Davis, S., Severson, R., Cerhan, J.R., Breen, E.C., Lan, Q., Brooks-Wilson, A., De Roos, A.J., Smith, M.T., Roman, E., Boffetta, P., Kricker, A., Zhang, Y., Skibola, C., Chanock, S.J., Rothman, N., Benavente, Y., Hartge, P., and Smedby, K.E.

Subjects
Lymphoma, Epidemiology, Original Contributions, tumor necrosis factor, Follicular lymphoma, Non-Hodgkin, interaction, Single-nucleotide polymorphism, Human leukocyte antigen, medicine.disease_cause, Polymorphism, Single Nucleotide, Autoimmune Disease, Medical and Health Sciences, Mathematical Sciences, Autoimmunity, Autoimmune Diseases, Rare Diseases, immune system diseases, HLA Antigens, human leukocyte antigen, hemic and lymphatic diseases, Genotype, medicine, Genetics, Humans, 2.1 Biological and endogenous factors, Polymorphism, Aetiology, Cancer, business.industry, Tumor Necrosis Factor-alpha, Lymphoma, Non-Hodgkin, Inflammatory and immune system, autoimmune conditions, Odds ratio, Single Nucleotide, Hematology, medicine.disease, Autoimmune conditions - risk of non-Hodgkin lymphoma (NHL), Interleukin-10, Case-Control Studies, Immunology, HIV/AIDS, business, Diffuse large B-cell lymphoma, environment
Abstract

Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04). © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

Published
2015

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