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52. Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy

Author

Bonati, L., Ederle, J., Dobson, J., Engelter, S., Featherstone, R., Gaines, P., Beard, J., Venables, G., Markus, H., Clifton, A., Sandercock, P., Brown, M., Bland, J., Buckenham, T., Taylor, R., Tognoni, G., Warlow, C., Bleakley, T., Colquhoun, D., Coward, L., Crawley, F., Dobinson, P., Holder, S., McCabe, D., Pereira, A., Rogers, J., Silver, L., Burrett, J., Crowther, J., Dobson, M., Hafner, B., Heineman, J., Hope, C., Knight, S., Naughten, A., Radley, A., Richards, S., Smith, D., Wenzel, S., Harrison, M., Ferro, J., Bladin, C., Donnan, G., Fell, G., Fitt, G., Royle, J., Davis, S., Gerraty, R., Mitchell, P., Goodman, M., Hankey, G., Khangure, M., Lawrence-Brown, Michael, Linto, J., McAuliffe, W., Prendergast, F., Siennarine, K., Stewart-Wynne, E., Grahovac, S., Morrish, W., Pageau, N., E Pringle, C., Richard, D., Malms, J., Reiher, L., Siebler, M., Belloni, G., Porta, M., Chamorro, A., Vila, N., Riambau, V., Vazquez, F., Boza, F., Garcia Rodríguez, J., Gil Peralta, A., González, A., González Marcos, J., Mayol Deya, A., Rauno, J., Kirsch, E., Lyrer, P., Rem, J., Bogousslavsky, J., Uske, A., Cleveland, T., Doyle, C., Sivaguru, A., Leopold, P., Loosemore, T., Enevoldson, T., Gilling-Smith, G., Harris, P., Nixon, T., Baskerville, P., Cox, T., Fraser, S., Jeffrey, M., Molloy, J., Butler, P., Dick, J., Frankel, F., Bradbury, A., Collie, D., Murie, J., Ruckley, C., Schultz, D., Sellar, R., Wardlaw, J., Ashleigh, R., McCollum, C., O'Neill, P., Gholkar, A., Mendelow, A., Walls, T., Angus-Leppan, H., Halpin, S., Hughes, J., Lane, I., Wiles, M., Wood, A., Birch, P., Earnshaw, J., Fuller, G., Heather, B., Poskitt, K., Tottle, A., Hope, D., Jefferson, D., McConachie, N., Duddy, M., Heafield, M., Vohra, R., Bonati, L., Ederle, J., Dobson, J., Engelter, S., Featherstone, R., Gaines, P., Beard, J., Venables, G., Markus, H., Clifton, A., Sandercock, P., Brown, M., Bland, J., Buckenham, T., Taylor, R., Tognoni, G., Warlow, C., Bleakley, T., Colquhoun, D., Coward, L., Crawley, F., Dobinson, P., Holder, S., McCabe, D., Pereira, A., Rogers, J., Silver, L., Burrett, J., Crowther, J., Dobson, M., Hafner, B., Heineman, J., Hope, C., Knight, S., Naughten, A., Radley, A., Richards, S., Smith, D., Wenzel, S., Harrison, M., Ferro, J., Bladin, C., Donnan, G., Fell, G., Fitt, G., Royle, J., Davis, S., Gerraty, R., Mitchell, P., Goodman, M., Hankey, G., Khangure, M., Lawrence-Brown, Michael, Linto, J., McAuliffe, W., Prendergast, F., Siennarine, K., Stewart-Wynne, E., Grahovac, S., Morrish, W., Pageau, N., E Pringle, C., Richard, D., Malms, J., Reiher, L., Siebler, M., Belloni, G., Porta, M., Chamorro, A., Vila, N., Riambau, V., Vazquez, F., Boza, F., Garcia Rodríguez, J., Gil Peralta, A., González, A., González Marcos, J., Mayol Deya, A., Rauno, J., Kirsch, E., Lyrer, P., Rem, J., Bogousslavsky, J., Uske, A., Cleveland, T., Doyle, C., Sivaguru, A., Leopold, P., Loosemore, T., Enevoldson, T., Gilling-Smith, G., Harris, P., Nixon, T., Baskerville, P., Cox, T., Fraser, S., Jeffrey, M., Molloy, J., Butler, P., Dick, J., Frankel, F., Bradbury, A., Collie, D., Murie, J., Ruckley, C., Schultz, D., Sellar, R., Wardlaw, J., Ashleigh, R., McCollum, C., O'Neill, P., Gholkar, A., Mendelow, A., Walls, T., Angus-Leppan, H., Halpin, S., Hughes, J., Lane, I., Wiles, M., Wood, A., Birch, P., Earnshaw, J., Fuller, G., Heather, B., Poskitt, K., Tottle, A., Hope, D., Jefferson, D., McConachie, N., Duddy, M., Heafield, M., and Vohra, R.

Abstract

Background: The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been investigated in randomized trials. Methods: In 414 patients with mostly symptomatic carotid stenosis randomized to endovascular treatment (angioplasty or stenting; n=213) or carotid endarterectomy (n=211) in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), the degree and length of stenosis and plaque surface irregularity were assessed on baseline intraarterial angiography. Outcome measures were stroke or death occurring between randomization and 30 days after treatment, and ipsilateral stroke and restenosis =50% during follow-up. Results: Carotid stenosis longer than 0·65 times the common carotid artery diameter was associated with increased risk of peri-procedural stroke or death after both endovascular treatment [odds ratio 2·79 (1·17-6·65), P=0·02] and carotid endarterectomy [2·43 (1·03-5·73), P=0·04], and with increased long-term risk of restenosis in endovascular treatment [hazard ratio 1·68 (1·12-2·53), P=0·01]. The excess in restenosis after endovascular treatment compared with carotid endarterectomy was significantly greater in patients with long stenosis than with short stenosis at baseline (interaction P=0·003). Results remained significant after multivariate adjustment. No associations were found for degree of stenosis and plaque surface. Conclusions: Increasing stenosis length is an independent risk factor for peri-procedural stroke or death in endovascular treatment and carotid endarterectomy, without favoring one treatment over the other. However, the excess restenosis rate after endovascular treatment compared with carotid endarterectomy increases with longer stenosis at baseline. Stenosis length merits further investigation in carotid revascularisation trials. © 2013 The Authors. International Journal of Strok

Published
2014

56. Gli studi sul tempo narrativo

Author

Albonico, S, Cabani, MC, Matarrese, T, Morato, N, Afribo, A, Montagnani, C, Stroppa, S, Soldani, A, Barenghi, M, Leonardi, L, Bocchi, G, Belloni, G, Gagliardi, P, Praloran, E, Pelosi, A, Pedroni, MM, BARENGHI, MARIO LUIGI, Albonico, S, Cabani, MC, Matarrese, T, Morato, N, Afribo, A, Montagnani, C, Stroppa, S, Soldani, A, Barenghi, M, Leonardi, L, Bocchi, G, Belloni, G, Gagliardi, P, Praloran, E, Pelosi, A, Pedroni, MM, and BARENGHI, MARIO LUIGI

Abstract

Questo articolo illustra il contributo fornito da Marco Praloran allo studio della temporalità romanzesca. In particolare, ne mette in luce tre aspetti: la stretta connessione istituita tra le rappresentazioni narrative del tempo e dello spazio (in un racconto il divenire è sempre discontinuo e circoscritto), l’importanza della trattazione propriamente linguistica (la temporalità narrativa prende sempre forma attraverso un particolare uso dei tempi verbali) e il coinvolgimento entro l’analisi della temporalità narrativa dell’ordine cognitivo della comprensione, che si realizza nell’atto della lettura.

Published
2013

57. Effect of interferon-α on progression of cirrhosis to hepatocellular carcinoma: A retrospective cohort study

Author

Brunetto, M. R., Oliveri, F., Koehler, M., Zahm, F., Bonino, F., Darvich, J., Findor, J. A., Tanno, H., Pinchuk, L., Baldi, M., Colombatto, P., Colombo, M., Del Ninno, E., Fasani, P., Rumi, M. G., Tommasini, M., Alberti, A., Benvegnu, L., Chemello, L., De Salvo, G., Awetta, M., Antoniello, S., Pardo, F., Bruno, S., Podda, M., Andreone, P., Bernardi, M., Gasbarrini, G., D'Aquino, M., Tempesta, D., Bottelli, R., Devita, A., Masucci, F., Belloni, G., Mangia, A., Tappero, G., Caporaso, N., Mazzella, G., Puoti, M., Hoersch, S., and Al Traif, I.

Subjects
General Medicine
Published
1998

58. A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon

Author

Fattovich, G., Giustina, G., Favarato, S., Ruol, A., Macarri, G., Orlandi, E., Iaquinto, G., Ambrosone, L., Francavilla, A., Pastore, G., Santantonio, M. T., Romagno, D., Bolondi, L., Sofia, S., Marchesini, A., Pisi, E., Mazzella, G., Roda, E., Attaro, L., Chiodo, E., Mori, E., Verucchi, G., Lanzini, A., Salmi, A., Calvi, B., Bozzetti, E., Radaeli, E., Bernasconi, M., Pilleri, G., Bacca, D., Romano, G., Mastrapasqua, G., Cozzolongo, R., Cacopardo, B., Nunnari, A., Blasi, A., Sala, L. O., Minoli, G., Sangiovanni, A., Spinzi, G. C., Colombo, A., Camassa, M., Riva, D., Maggi, G., Boccia, S., Gualandi, G., Nucci, A., Pacini, F., Marino, N., Mazzotta, E., La Mura, A., Pompei, A. G., Casinelli, K., Petrosillo, N., Giacchino, R., Timitilli, A., Spiga, E., Corsetti, M., Menicagli, V., Tucci, A., Bissoli, E., Raimondo, G., Rodino, G., Bellobuono, A., Ideo, G., Colombo, M., Pacchetti, S., Rumi, M. R., Battezzati, P. M., Bruno, S., Podda, M., Zuin, M., Fargion, S., Fiorelli, G., Gellmann, E., Vandelli, C., Ventura, E., Manenti, F., Villa, E., Caporaso, N., Coltorti, M., Morisco, E., Del Vecchio-Blanco, C., di Santolo, S. S., Di Nunzio, S., Ruggiero, G., Zampino, R., Ascione, A., De Luca, M., Galeota-Lanza, A., Aprea, L., Sagnelli, E., Felaco, E. M., Piccinino, E., Ballare, M., Monteverde, A., Tappero, G., Sanna, G., Alberti, A., Bonetti, P., Casarin, C., Diodati, G., Tremolada, E., Naccarato, R., Chiaramonte, M., Floreani, M. R., Almasio, P., Craxi, A., Loiacono, O., Pagliaro, L., Fiaccadori, E., Giuberti, T., Belloni, G., Bernardini, E., Buscarini, L., Sbolli, G., Giudici-Cipriani, A., Marenco, G., Mazzaro, C., Massari, M., Fornaciari, G., Plancher, A., Gasbarrini, G., Grieco, A., Luchetti, R., Rapaccini, G. L., Bombardieri, G., Di Virgilio, D., Bruno, G., Ricci, G. L., Hassan, G., Mari, T., Scalisi, I., Colloredo, G., Frunzio, A., Tabone, M., Costa, C., Rosina, E., Saracco, G., Verme, G., Frezza, M., Urban, E., Capra, E., Casaril, M., Corrocher, R., and Benetti, G. P.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Hepatitis, Viral, Human, Alpha interferon, Poison control, Chronic viral hepatitis, Interferon alfa, Side effects, Gastroenterology, Autoimmune Diseases, Internal medicine, Medicine, Humans, Adverse effect, Child, Aged, Retrospective Studies, Hepatitis, Hepatology, business.industry, Thyroid disease, Mental Disorders, Infant, Newborn, Infant, Middle Aged, medicine.disease, Recombinant Proteins, Surgery, Bone marrow suppression, Child, Preschool, Chronic Disease, Interferon Type I, Female, business, Viral hepatitis, medicine.drug
Abstract

Aims: The aim of this study was to assess the incidence of fatal, life-threatening side effects and the de novo appearance of non-hepatic morbidity during interferon alfa therapy for chronic viral hepatitis. The relationship of these adverse events to actual total dose and duration of interferon was also evaluated. Methods: We conducted a retrospective study at 73 Italian centers of 11 241 consecutive patients with chronic vital hepatitis who underwent interferon alfa treatment. Results: Five patients died during interferon therapy due to liver failure ( n =4) or complications arising from sepsis. Life-threatening side effects were observed in eight patients: two cases where depression developed and led to a suicide attempt and six patients with bone marrow suppression (granulocytes 3 or platelets 3 ). These symptoms and signs completely disappeared after interferon withdrawal. During interferon treatment, 131 patients developed the following de novo non-hepatic disorders: symptomatic thyroid disease ( n =71), impotence ( n =5), systemic autoimmune disease ( n =5), immune-mediated dermatologic disease ( n =14), diabetes mellitus ( n =10), cardiovascular disease ( n =7), psychosis n =10), seizures ( n =4), peripheral neuropathy ( n =3) and hemolytic anemia ( n =2). Most of these complications are reversible or can be ameliorated. Fatal or life-threatening side effects were not related to actual total dose or duration of interferon alfa, while the majority of patients with de novo non-hepatic morbidity received medium/high doses ( > 200 million units) of interferon alfa or were treated for periods longer than 16 weeks (68% and 80%, respectively). Conclusions: Treatment with interferon alfa may have fatal or life-threatening side effects, their incidence in this study being low (0.04% and 0.07%, respectively) and perhaps no different than in untreated patients with chronic viral hepatitis. Moreover de novo non-hepatic morbidity occurred in 1.2% of patients, and the dose and duration of interferon therapy seem important in determining the frequency of this complication. The development of clinically-overt thyroid disease was most common.

Published
1996

60. Carotid percutaneous angioplasty

Author

M. Porta, Belloni G, Munari Lm, Perretti A, L Moschini, and Ghia Hf

Subjects
Male, medicine.medical_specialty, Percutaneous, Time Factors, medicine.medical_treatment, Transluminal Angioplasty, Percutaneous angioplasty, Carotid stenoses, otorhinolaryngologic diseases, Medicine, Humans, Carotid Stenosis, Endarterectomy, Probability, business.industry, General Medicine, Middle Aged, Surgery, Cerebral Angiography, Safety profile, Treatment Outcome, Neurology, Early results, Female, Neurology (clinical), Radiology, business, Angioplasty, Balloon, Carotid Artery, Internal, Follow-Up Studies
Abstract

Clinical benefit from treatment of symptomatic severe carotid stenoses has been demonstrated recently. The safety profile of endarterectomy, however, justifies the development of alternative techniques as percutaneous transluminal angioplasty (PTA), at least in mild to moderate stenoses. Early results and follow-up data from our series of 44 carotid stenoses treated by PTA are reviewed in this paper, in comparison with other reports from literature. PTA may be beneficial as a therapy of symptomatic internal carotid stenoses, provided its cost/effectiveness has been evaluated by a valid method.

Published
1992

67. Evaluation of long-term efficacy of interferon alpha-2B and ribavirin in combination in naive patients with chronic hepatitis C: An italian multicenter experience

Author

Barbaro, G., primary, Di Lorenzo, G., additional, Belloni, G., additional, Ferrari, L., additional, Paiano, A., additional, Del Poggio, J., additional, Bacca, D., additional, Fruttaldo, L., additional, Mongiò, F., additional, Francavilla, R., additional, Scotto, G., additional, Grisorio, B., additional, Calleri, G., additional, Annese, M., additional, Barelli, A., additional, Rocchetto, P., additional, Rizzo, G., additional, Gualandi, G., additional, Poltronieri, I., additional, Pellicelli, A., additional, and Barbarini, G., additional

Published
2000
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68. Iron depletion and interferon (IFN) therapy: A multicenter, randomized trial in “naive” patients with chronic hepatitis C

Author

Fargion, S., primary, Ballarè, M., additional, Belloni, G., additional, Bissoli, F., additional, Borzio, M., additional, Ceriani, R., additional, Fiorelli, G., additional, Fracanzani, A.L., additional, Massari, M., additional, Mattioli, M., additional, Rossini, A., additional, Riggio, O., additional, and Trischitta, C., additional

Published
2000
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77. Angiofibroma rinofaringeo

Author

Quilici, N., primary, Scazzeri, F., additional, Prosetti, D., additional, Ferrito, G., additional, Moschini, L., additional, and Belloni, G., additional

Published
1994
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88. The autoregulatory capability of Galen's rete cerebri and its connections.

Author

Boulay, G., Kendall, B., Crockard, A., Sage, M., and Belloni, G.

Abstract

Copyright of Neuroradiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1975
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89. The vasodilator action of angiography with Urografin 60% on the basal vessels of the brain of the baboon.

Author

Boulay, G., Kendall, B., Symon, L., Pasztor, E., Crockard, A., Belloni, G., and Sage, M.

Abstract

Copyright of Neuroradiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1975
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91. Dementia after first stroke.

Author

Censori B, Manara O, Agostinis C, Camerlingo M, Casto L, Galavotti B, Partziguian T, Servali MC, Cesana B, Belloni G, Mamoli A, Censori, B, Manara, O, Agostinis, C, Camerlingo, M, Casto, L, Galavotti, B, Partziguian, T, Servalli, M C, and Cesana, B

Published
1996
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98. Epilessia vegetativa.

Author

Belloni, G. and Terzian, H.

Abstract

Copyright of Acta Neurovegetativa is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1962
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99. On the Experimental Calibration of a Potential Drop System for Crack Length Measurements in a Compact Tension Specimen

Author

Belloni, G, Gariboldi, E, Lo Conte, A, Tono, M, and Speranzoso, P

Abstract

The present study was focused on the setup of a system for monitoring deep cracks in notched specimens in creep and fatigue laboratory tests. The test configuration features, the instrumentation requirements, and the important problems of the calibration for potential drop application to both fatigue and creep crack growth tests on compact tension specimens are discussed in detail. Experimental tests on the compact tension specimen geometry were carried out at ambient and high temperatures in order to define and validate an experimental calibration for this specimen geometry, to check the effect of temperature, and to compare the crack growth calibration curves under creep or fatigue conditions.

Published
2002
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100. Study of the effectiveness of bronchial clearance in subjects with upper spinal cord injuries: examination of a rehabilitation programme involving mechanical insufflation and exsufflation.

Author

Pillastrini, P., Bordini, S., Bazzocchi, G., Belloni, G., and Menarini, M.

Subjects
SPINAL cord, WOUNDS & injuries, TRACHEOTOMY, THERAPEUTICS, PATIENT participation, RESEARCH institutes
Abstract

Study design:Randomized controlled trial.Objectives:To establish whether the use of mechanical insufflation/exsufflation leads to a significant improve in tracheostomy subjects with upper spinal cord injuries (C1–C7), ASIA classification grade A and bronchial hyper secretion the following parameters: forced vital capacity (FVC), forced exspiratory volume on the first second (FEV1), FEV1/FVC, peak exspiratory flow (PEF), arterious pressure of O2 (Pa O2), arterious pressure of CO2 (Pa CO2), pH, saturation of O2 (Sa O2).Setting:Spinal Cord Unit, Montecatone Rehabilitation Institute, Imola, Italy.Methods:The patients were split into two groups: the experimental group (EG) and the control group (CG). Each patient was given 10 treatments: the EG was given manual respiratory kinesitherapy associated with mechanical insufflation/exsufflation with inhale and exhale pressure between 15 cm H2O and 45 cm H2O, while the CG was only given manual kinesitherapy. The treatment sessions covered the necessary amount of time in order to achieve sufficient clearance. The study has been approved by the local ethic committee. The patients were informed before being enrolled in that study and gave their written consent.Results:At the end of the treatment associated with the mechanical insufflation/exsufflation, the EG showed a significant increase in FVC, FEV1 and PEF, although it was not possible to compare the latter with the CG. The other parameters were also subject to variations, although not statistically significant. The CG did not show signs of any significant change.Conclusion:The use of mechanical insufflation/exsufflation in subjects with the aforementioned characteristics is shown to be an effective adjunct to manual respiratory kinesitherapy, since it makes it possible to achieve adequate bronco-pulmonary clearance, even removing thick, deep secretions and making it possible to insufflate any areas affected by atelectasis.Spinal Cord (2006) 44, 614–616. doi:10.1038/sj.sc.3101870; published online 13 December 2005 [ABSTRACT FROM AUTHOR]

Published
2006
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