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51. The histopathology of SPINK1-associated chronic pancreatitis

Author

Jones, Terrell E., Bellin, Melena D., Yadav, Dhiraj, Freeman, Martin L., Schwarzenberg, Sarah J., Slivka, Adam, Chennat, Jennifer S., Beilman, Gregory J., Chinnakotla, Srinath, Pruett, Timothy L., Kirchner, Varvara, Humar, Abhinav, Wijkstrom, Martin, Zureikat, Amer H., Nikiforova, Marina N., Wald, Abigail I., Whitcomb, David C., and Singhi, Aatur D.

Published
2020
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52. Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis

Author

Zhan, Wei, Akshintala, Venkata, Greer, Phil J., Greer, Julia B., Alkaade, Samer, Anderson, Michelle A., Muniraj, Thiruvengadam, Papachristou, Georgios I., Sandhu, Bimaljit S., Slivka, Adam, Wilcox, C. Mel, Bellin, Melena D., Singh, Vikesh K., Yadav, Dhiraj, Brand, Randall E., and Whitcomb, David C.

Published
2020
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54. The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis

Author

Abu-El-Haija, Maisam, Anazawa, Takayuki, Beilman, Gregory J., Besselink, Marc G., Del Chiaro, Marco, Demir, Ihsan Ekin, Dennison, Ashley R., Dudeja, Vikas, Freeman, Martin L., Friess, Helmut, Hackert, Thilo, Kleeff, Jorg, Laukkarinen, Johanna, Levy, Marlon F., Nathan, Jaimie D., Werner, Jens, Windsor, John A., Neoptolemos, John P., Sheel, Andrea R.G., Shimosegawa, Tooru, Whitcomb, David C., and Bellin, Melena D.

Published
2020
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55. Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Author

Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Dias Costa, Andressa, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., and Muzumdar, Mandar Deepak

Published
2020
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58. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer

Author

Hart, Phil A, Bellin, Melena D, Andersen, Dana K, Bradley, David, Cruz-Monserrate, Zobeida, Forsmark, Christopher E, Goodarzi, Mark O, Habtezion, Aida, Korc, Murray, Kudva, Yogish C, Pandol, Stephen J, Yadav, Dhiraj, Chari, Suresh T, and Consortium for the Study of Chronic Pancreatitis, Diabetes

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition, Diabetes, Cancer, Rare Diseases, Pancreatic Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Carcinoma, Pancreatic Ductal, Diabetes Mellitus, Humans, Pancreatic Neoplasms, Pancreatitis, Chronic, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer(CPDPC), Clinical sciences
Abstract

Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.

Published
2016

59. Preoperative Computerized Tomography and Magnetic Resonance Imaging of the Pancreas Predicts Pancreatic Mass and Functional Outcomes After Total Pancreatectomy and Islet Autotransplant

Author

Young, Michael C, Theis, Jake R, Hodges, James S, Dunn, Ty B, Pruett, Timothy L, Chinnakotla, Srinath, Walker, Sidney P, Freeman, Martin L, Trikudanathan, Arain, Mustafa, Robertson, Paul R, Wilhelm, Joshua J, Schwarzenberg, Sarah J, Bland, Barbara, Beilman, Gregory J, and Bellin, Melena D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Rare Diseases, Biomedical Imaging, Clinical Research, Autoimmune Disease, Digestive Diseases, Metabolic and endocrine, Adolescent, Adult, Autografts, Female, Humans, Islets of Langerhans Transplantation, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Pancreas, Pancreatectomy, Pancreatitis, Chronic, Preoperative Period, Tomography, X-Ray Computed, Treatment Outcome, Young Adult, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesApproximately two thirds of patients will remain on insulin therapy after total pancreatectomy with islet autotransplant (TPIAT) for chronic pancreatitis. We investigated the relationship between measured pancreas volume on computerized tomography or magnetic resonance imaging and features of chronic pancreatitis on imaging, with subsequent islet isolation and diabetes outcomes.MethodsComputerized tomography or magnetic resonance imaging was reviewed for pancreas volume (Vitrea software) and presence or absence of calcifications, atrophy, and dilated pancreatic duct in 97 patients undergoing TPIAT. Relationship between these features and (1) islet mass isolated and (2) diabetes status at 1-year post-TPIAT were evaluated.ResultsPancreas volume correlated with islet mass measured as total islet equivalents (r = 0.50, P < 0.0001). Mean islet equivalents were reduced by more than half if any one of calcifications, atrophy, or ductal dilatation were observed. Pancreatic calcifications increased the odds of insulin dependence 4.0 fold (1.1, 15). Collectively, the pancreas volume and 3 imaging features strongly associated with 1-year insulin use (P = 0.07), islet graft failure (P = 0.003), hemoglobin A1c (P = 0.0004), fasting glucose (P = 0.027), and fasting C-peptide level (P = 0.008).ConclusionsMeasures of pancreatic parenchymal destruction on imaging, including smaller pancreas volume and calcifications, associate strongly with impaired islet mass and 1-year diabetes outcomes.

Published
2016

60. Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

Author

Hering, Bernhard J, Clarke, William R, Bridges, Nancy D, Eggerman, Thomas L, Alejandro, Rodolfo, Bellin, Melena D, Chaloner, Kathryn, Czarniecki, Christine W, Goldstein, Julia S, Hunsicker, Lawrence G, Kaufman, Dixon B, Korsgren, Olle, Larsen, Christian P, Luo, Xunrong, Markmann, James F, Naji, Ali, Oberholzer, Jose, Posselt, Andrew M, Rickels, Michael R, Ricordi, Camillo, Robien, Mark A, Senior, Peter A, Shapiro, AM James, Stock, Peter G, and Turgeon, Nicole A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Autoimmune Disease, Transplantation, Clinical Trials and Supportive Activities, Diabetes, Metabolic and endocrine, Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Immunosuppression Therapy, Islets of Langerhans Transplantation, Male, Middle Aged, North America, Young Adult, Clinical Islet Transplantation Consortium, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveImpaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D). Current therapies are effective in preventing SHEs in 50-80% of patients with IAH and SHEs, leaving a substantial number of patients at risk. We evaluated the effectiveness and safety of a standardized human pancreatic islet product in subjects in whom IAH and SHEs persisted despite medical treatment.Research design and methodsThis multicenter, single-arm, phase 3 study of the investigational product purified human pancreatic islets (PHPI) was conducted at eight centers in North America. Forty-eight adults with T1D for >5 years, absent stimulated C-peptide, and documented IAH and SHEs despite expert care were enrolled. Each received immunosuppression and one or more transplants of PHPI, manufactured on-site under good manufacturing practice conditions using a common batch record and standardized lot release criteria and test methods. The primary end point was the achievement of HbA1c 0.0001). No study-related deaths or disabilities occurred. Five of the enrollees (10.4%) experienced bleeds requiring transfusions (corresponding to 5 of 75 procedures), and two enrollees (4.1%) had infections attributed to immunosuppression. Glomerular filtration rate decreased significantly on immunosuppression, and donor-specific antibodies developed in two patients.ConclusionsTransplanted PHPI provided glycemic control, restoration of hypoglycemia awareness, and protection from SHEs in subjects with intractable IAH and SHEs. Safety events occurred related to the infusion procedure and immunosuppression, including bleeding and decreased renal function. Islet transplantation should be considered for patients with T1D and IAH in whom other, less invasive current treatments have been ineffective in preventing SHEs.

Published
2016

61. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE

Author

Kumar, Soma, Ooi, Chee Y, Werlin, Steven, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D, Durie, Peter R, Fishman, Douglas S, Freedman, Steven D, Gariepy, Cheryl, Giefer, Matthew J, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan, Husain, Sohail Z, Lin, Tom K, Lowe, Mark E, Morinville, Veronique, Palermo, Joseph J, Pohl, John F, Schwarzenberg, Sarah Jane, Troendle, David, Wilschanski, Michael, Zimmerman, M Bridget, and Uc, Aliye

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Pediatric Research Initiative, Prevention, Pain Research, Digestive Diseases, Pediatric Cancer, Chronic Pain, Cancer, Clinical Research, Oral and gastrointestinal, Good Health and Well Being, Abdominal Pain, Acute Disease, Carrier Proteins, Child, Chymotrypsin, Cost of Illness, Cross-Sectional Studies, Cystic Fibrosis Transmembrane Conductance Regulator, Disease Progression, Emergency Service, Hospital, Female, Genetic Predisposition to Disease, Hospitalization, Humans, Male, Mutation, Pancreatitis, Pancreatitis, Chronic, Recurrence, Risk Factors, Trypsin, Trypsin Inhibitor, Kazal Pancreatic, Paediatrics
Abstract

ImportancePediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood.ObjectiveTo characterize and identify risk factors associated with ARP and CP in childhood.Design, setting, and participantsA multinational cross-sectional study of children with ARP or CP at the time of enrollment to the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) study at participant institutions of the INSPPIRE Consortium. From August 22, 2012, to February 8, 2015, 155 children with ARP and 146 with CP (aged ≤19 years) were enrolled. Their demographic and clinical information was entered into the REDCap (Research Electronic Data Capture) database at the 15 centers. Differences were analyzed using 2-sample t test or Wilcoxon rank sum test for continuous variables and Pearson χ2 test or Fisher exact test for categorical variables. Disease burden variables (pain variables, hospital/emergency department visits, missed school days) were compared using Wilcoxon rank sum test.Main outcomes and measuresDemographic characteristics, risk factors, abdominal pain, and disease burden.ResultsA total of 301 children were enrolled (mean [SD] age, 11.9 [4.5] years; 172 [57%] female); 155 had ARP and 146 had CP. The majority of children with CP (123 of 146 [84%]) reported prior recurrent episodes of acute pancreatitis. Sex distribution was similar between the groups (57% female in both). Hispanic children were less likely to have CP than ARP (17% vs 28%, respectively; odds ratio [OR] = 0.51; 95% CI, 0.29-0.92; P = .02). At least 1 gene mutation in pancreatitis-related genes was found in 48% of patients with ARP vs 73% of patients with CP (P

Published
2016

62. Toxic-metabolic Risk Factors in Pediatric Pancreatitis

Author

Husain, Sohail Z, Morinville, Veronique, Pohl, John, Abu-El-Haija, Maisam, Bellin, Melena D, Freedman, Steve, Hegyi, Peter, Heyman, Melvin B, Himes, Ryan, Ooi, Chee Y, Schwarzenberg, Sarah J, Usatin, Danielle, and Uc, Aliye

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Alcoholism, Alcohol Use and Health, Prevention, Tobacco Smoke and Health, Pediatric Research Initiative, Pediatric, Tobacco, Kidney Disease, Substance Misuse, Digestive Diseases, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Alcohol Drinking, Biomedical Research, Child, Drug-Related Side Effects and Adverse Reactions, Evidence-Based Medicine, Female, Humans, Hypercalcemia, Hypertriglyceridemia, Kidney Failure, Chronic, Male, Pancreatitis, Pediatrics, Practice Guidelines as Topic, Risk Factors, Smoking, hypercalcemia, chronic pancreatitis, acute pancreatitis, smoking, hypertriglyceridemia, alcohol, medications, acute recurrent pancreatitis, chronic renal failure, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

Pancreatitis in children can result from metabolic and toxic risk factors, but the evidence linking these factors is sparse. We review the evidence for association or causality of these risk factors in pancreatitis, discuss management strategies, and their rationale. We conducted a review of the pediatric pancreatitis literature with respect to the following risk factors: hyperlipidemia, hypercalcemia, chronic renal failure, smoking exposure, alcohol, and medications. Areas of additional research were identified. Hypertriglyceridemia of 1000 mg/dL or greater poses an absolute risk for pancreatitis; persistent elevations of calcium are predisposing. Further research is necessary to determine whether end-stage renal disease leads to increased pancreatitis in children similar to adults. It is unknown whether cigarette smoking exposure, which clearly increases risk in adults, also increases risk in children. The role of alcohol in pediatric pancreatitis, whether direct or modifying, needs to be elucidated. The evidence supporting most cases of medication-induced pancreatitis is poor. Drug structure, improper handling of drug by host, and bystander status may be implicated. Other pancreatitis risk factors must be sought in all cases. The quality of evidence supporting causative role of various toxic and metabolic factors in pediatric pancreatitis is variable. Careful phenotyping is essential, including search for other etiologic risk factors. Directed therapy includes correction/removal of any agent identified, and general supportive measures. Further research is necessary to improve our understanding of these pancreatitis risk factors in children.

Published
2016

63. Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry

Author

Ting, Jie, Wilson, Leslie, Schwarzenberg, Sarah Jane, Himes, Ryan, Barth, Bradley, Bellin, Melena D, Durie, Peter R, Fishman, Douglas S, Freedman, Steven D, Gariepy, Cheryl E, Giefer, Matthew J, Gonska, Tanja, Husain, Sohail Z, Kumar, Soma, Morinville, Veronique D, Lowe, Mark E, Ooi, Chee Y, Pohl, John F, Troendle, David, Usatin, Danielle, Werlin, Steven L, Wilschanski, Michael, Heyman, Melvin B, and Uc, Aliye

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Services, Chronic Pain, Clinical Research, Cancer, Pain Research, Pediatric, Digestive Diseases, Burden of Illness, 8.1 Organisation and delivery of services, Health and social care services research, Oral and gastrointestinal, Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Health Care Costs, Hospital Costs, Hospitalization, Humans, Infant, Male, Pancreatitis, Patient Acceptance of Health Care, Recurrence, Registries, Young Adult, economic, health care costs, hospitalization, pain, quality of life, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

ObjectiveTo estimate selected direct medical care costs of children with chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP).MethodsWe performed a cross-sectional study of data from International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE), a multinational registry of children with ARP or CP. We determined health care utilization and estimated costs of hospitalizations, surgical and endoscopic procedures, and medications in our study population. Health care utilization data were obtained from all subjects enrolled in the study, and costs were calculated using national United States costs.ResultsWe included 224 subjects (median age 12.7 years), 42% of whom had CP. Mean number of hospitalizations, including for surgery and endoscopic retrograde cholangiopancreatography, was 2.3 per person per year, costing an estimated average $38,755 per person per year. Including outpatient medications, estimated total mean cost was $40,589 per person per year. Subjects using surgical procedures or endoscopic retrograde cholangiopancreatography incurred mean annual costs of $42,951 per person and $12,035 per person, respectively. Estimated annual costs of pancreatic enzyme replacement therapy, diabetic medications, and pain medications were $4114, $1761, and $614 per person, respectively. In an exploratory analysis, patients with the following characteristics appear to accrue higher costs than those without them: more frequent ARP attacks per year, reported constant or episodic pain, family history of pancreatic cancer, and use of pain medication.ConclusionsARP and CP are uncommon childhood conditions. The severe burden of disease associated with these conditions and their chronicity results in high health care utilization and costs. Interventions that reduce the need for hospitalization could lower costs for these children and their families.

Published
2016

64. Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC)

Author

Palermo, Tonya M., Murray, Caitlin, Aalfs, Homer, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D., Ellery, Kate, Fishman, Douglas S., Gariepy, Cheryl E., Giefer, Matthew J., Goday, Praveen, Gonska, Tanja, Heyman, Melvin B., Husain, Sohail Z., Lin, Tom K., Liu, Quin Y., Mascarenhas, Maria R., Maqbool, Asim, McFerron, Brian, Morinville, Veronique D., Nathan, Jaimie D., Ooi, Chee Y., Perito, Emily R., Pohl, John F., Schwarzenberg, Sarah Jane, Sellers, Zachary M., Serrano, Jose, Shah, Uzma, Troendle, David, Zheng, Yuhua, Yuan, Ying, Lowe, Mark, and Uc, Aliye

Published
2020
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65. Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality

Author

Serrano, Jose, Laughlin, Maren R., Bellin, Melena D., Yadav, Dhiraj, Chinchilli, Vernon M., Andersen, Dana K., Greenbaum, Carla, Kozarek, Richard, Speake, Cate, Lord, Sandra, Irani, Shayan, Linsley, Peter, Kwok, William, Lacy-Hulbert, Adam, Hamerman, Jessica, Bahnson, Henry, Grubb, Brooke, Williams, Cassandra, Ackermann, Sarah, Varner, Kimberly, Goodarzi, Mark O., Pandol, Stephen J., Buxbaum, James, Diniz, Marcio, Goodman, Marc, Hines, O. Joe, Jeon, Christie, Korc, Murray, Li, Debiao, Petrov, Maxim, Pisegna, Joseph, Van Eyk, Jennifer, Vege, Santhi Swaroop, Fogel, Evan, Evans-Molina, Carmella, Tirkes, Temel, Sherman, Stuart, Easler, Jeffrey, Saeed, Zed, Sims, Emily, Oram, Richard, Weedon, Michael, Singh, Vikesh, Sun, Zhaoli, Afghani, Elham, Kalyani, Rita, Jacobs, Michael, Zaheer, Atif, Zhu, Heng, Akshintala, Venkata S., Papachristou, Georgios I., Hart, Phil A., Conwell, Darwin L., Bradley, David, Dungan, Kathleen, Shah, Zarine, Krebs, Zoe, Hazelett, Samantha, Forsmark, Christopher E., Casu, Anna, Hughes, Steven, Pratley, Richard E., Thompson, Martha Campbell, Wasserfall, Clive, Grajo, Joseph, Yazici, Cemal, Layden, Brian, Danielson, Kirstie, Boulay, Brian, Villa, Edward, Mutlu, Ece, Xia, Yinglin, Green, Stefan, Tussing-Humphreys, Lisa, Prabhakar, Bellur, Gaba, Ron, Ratia, Kiira, Daviglus, Martha, Spaggiari, Mario, Grippo, Paul J., Setiawan, Veronica, Keswani, Rajesh, Komanduri, Srinadh, Aadam, Aziz, Bellin, Melena, Trikudanathan, Guru, Fife, Brian, Freeman, Martin, Harindhanavudhi, Tasma, Moran, Antoinette, Spilseth, Benjamin, Hodges, James, Yadav, Dhiraj, Toledo, Frederico G. S., Dasyam, Anil, Phillips, Anna E., Kang, Chae-Ryon, Yechoor, Vijay, Saloman, Jami, Becker, Dorothy, Reynolds, Shari, Hall, Kristin, Stello, Kim, Mays, Melanie, Saul, Melissa, Park, Walter G., Basina, Marina, Habtezion, Aida, Poullos, Peter, Meyer, Everett, Chinchilli, Vernon M., Kong, Lan, Liu, Dajiang, Maranki, Jennifer, McCormick, Jennifer, Pichardo-Lowden, Ariana, Siddiqui, Ayesha, Raja-Khan, Nazia, Wang, Ming, Zhan, Xiang, Bottino, Rita, Faulkner, Georgia, Baab, Kendall Thomas, Dyer, Anne-Marie, Guzman, Jennifer, Holmes, Beth, Baron, Rose, Merchlinski, Aimee, Valencia-Moulton, Paula, Broach, James, and Bradley, David

Published
2022
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68. Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Dungan, Kathleen M., Hart, Phil A., Andersen, Dana K., Basina, Marina, Chinchilli, Vernon M., Danielson, Kirstie K., Evans-Molina, Carmella, Goodarzi, Mark O., Greenbaum, Carla J., Kalyani, Rita R., Laughlin, Maren R., Pichardo-Lowden, Ariana, Pratley, Richard E., Serrano, Jose, Sims, Emily K., Speake, Cate, Yadav, Dhiraj, Bellin, Melena D., and Toledo, Frederico G. S.

Published
2022
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69. Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Yazici, Cemal, Dyer, Anne-Marie, Conwell, Darwin L., Afghani, Elham, Andersen, Dana K., Basina, Marina, Bellin, Melena D., Boone, Leslie R., Casu, Anna, Easler, Jeffrey J., Greenbaum, Carla J., Hart, Phil A., Jeon, Christie Y., Lee, Peter J., Meier, Shelby, Papachristou, Georgios I., Raja-Khan, Nazia T., Saeed, Zeb I., Serrano, Jose, Yadav, Dhiraj, and Fogel, Evan L.

Published
2022
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70. Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Tirkes, Temel, Chinchilli, Vernon M., Bagci, Ulas, Parker, Jason G., Zhao, Xuandong, Dasyam, Anil K., Feranec, Nicholas, Grajo, Joseph R., Shah, Zarine K., Poullos, Peter D., Spilseth, Benjamin, Zaheer, Atif, Xie, Karen L., Wachsman, Ashley M., Campbell-Thompson, Martha, Conwell, Darwin L., Fogel, Evan L., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Pratley, Richard E., Yazici, Cemal, Laughlin, Maren R., Andersen, Dana K., Serrano, Jose, Bellin, Melena D., and Yadav, Dhiraj

Published
2022
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71. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Wasserfall, Clive, Dyer, Anne-Marie, Speake, Cate, Andersen, Dana K., Baab, Kendall Thomas, Bellin, Melena D., Broach, James R., Campbell-Thompson, Martha, Chinchilli, Vernon M., Lee, Peter J., Park, Walter G., Pratley, Richard E., Saloman, Jami L., Sims, Emily K., Tang, Gong, Yadav, Dhiraj, Yazici, Cemal, and Conwell, Darwin L.

Published
2022
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72. Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Casu, Anna, Grippo, Paul J., Wasserfall, Clive, Sun, Zhaoli, Linsley, Peter S., Hamerman, Jessica A., Fife, Brian T., Lacy-Hulbert, Adam, Toledo, Frederico G.S., Hart, Phil A., Papachristou, Georgios I., Bellin, Melena D., Yadav, Dhiraj, Laughlin, Maren R., Goodarzi, Mark O., and Speake, Cate

Published
2022
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73. Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis

Author

Lee, Bomi, Adamska, Julia Z., Namkoong, Hong, Bellin, Melena D., Wilhelm, Josh, Louis, Gregory L. SzoDavid M., Davis, Mark M., Pandol, Stephen J., and Habtezion, Aida

Subjects
Analysis, Development and progression, Macrophages -- Analysis, Pancreatitis -- Development and progression, Medical research -- Analysis, Organ transplantation -- Analysis, T cells -- Analysis, Genes, Surgery, Immune response, Pancreatectomy, Diseases, Autografts
Abstract

Introduction Chronic pancreatitis (CP) is an inflammatory disease of the pancreas and remains a major source of morbidity in the United States and Europe (1). CP is associated with an [...], Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of [CD68.sup.+] macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in [CD3.sup.+] T cell frequency, which prompted us to investigate the T cell receptor [beta] (TCR[beta]) repertoire in the CP and control groups. TCR[beta] sequencing revealed a significant increase in TCR[beta] repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in V[beta]-J[beta] gene family usage between hereditary and idiopathic CP and a positive correlation of TCR[beta] rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.

Published
2020
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78. Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients

Author

Abdel-Karim, Tasneem R., primary, Hodges, James S., additional, Herold, Kevan C., additional, Pruett, Timothy L., additional, Ramanathan, Karthik V., additional, Hering, Bernhard J., additional, Dunn, Ty B., additional, Kirchner, Varvara A., additional, Beilman, Gregory J., additional, and Bellin, Melena D., additional

Published
2024
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80. Design and Implementation of INSPPIRE

Author

Morinville, Veronique D, Lowe, Mark E, Ahuja, Monika, Barth, Bradley, Bellin, Melena D, Davis, Heather, Durie, Peter R, Finley, Brian, Fishman, Douglas S, Freedman, Steven D, Gariepy, Cheryl E, Giefer, Matthew J, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan, Husain, Sohail, Kumar, Soma, Ooi, Chee Y, Pohl, John F, Schwarzenberg, Sarah Jane, Troendle, David, Werlin, Steven L, Wilschanski, Michael, Yen, Elizabeth, and Uc, Aliye

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Pediatric Cancer, Burden of Illness, Digestive Diseases, Pediatric, Prevention, Cancer, Pediatric Research Initiative, Clinical Research, Good Health and Well Being, Adolescent, Biomedical Research, Child, Database Management Systems, Databases, Factual, Female, Humans, International Cooperation, Male, Pancreatitis, Pancreatitis, Chronic, Recurrence, Registries, Research Design, Surveys and Questionnaires, acute recurrent pancreatitis, children, chronic pancreatitis, database, questionnaire, registry, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

ObjectivesAcute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are rare and poorly understood diseases in children. Better understanding of these disorders can only be accomplished via a multicenter, structured, data collection approach.MethodsThe International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was created to investigate the epidemiology, etiologies, pathogenesis, natural history, and outcomes of pediatric ARP and CP. Patient and physician questionnaires were developed to capture information on demographics, medical history, family and social history, medications, hospitalizations, risk factors, diagnostic evaluation, treatments, and outcome information. Information collected in paper questionnaires was then transferred into Research Electronic Data Capture (REDCap), tabulated, and analyzed.ResultsThe administrative structure of the INSPPIRE consortium was established, and National Institutes of Health funding was obtained. A total of 14 sites (10 in the United States, 2 in Canada, and 2 overseas) participated. Questionnaires were amended and updated as necessary, followed by changes made into the REDCap database. Between September 1, 2012 and August 31, 2013, a total of 194 children were enrolled into the study: 54% were girls, 82% were non-Hispanic, and 72% were whites.ConclusionsThe INSPPIRE consortium demonstrates the feasibility of building a multicenter patient registry to study the rare pediatric diseases, ARP and CP. Analyses of collected data will provide a greater understanding of pediatric pancreatitis and create opportunities for therapeutic interventional studies that would not otherwise be possible without a multicenter approach.

Published
2014

81. Early Metabolic Measures Predict Long-term Insulin Independence in Recipients of Total Pancreatectomy and Islet Autotransplantation

Author

Nanno, Yoshihide, primary, Hodges, James S., additional, Freeman, Martin L., additional, Trikudanathan, Guru, additional, Schwarzenberg, Sarah J., additional, Downs, Elissa M., additional, Ramanathan, Karthik, additional, Pruett, Timothy L., additional, Beilman, Gregory J., additional, Chinnakotla, Srinath, additional, Hering, Bernhard J., additional, and Bellin, Melena D., additional

Published
2023
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83. TPIAT improves pain burden and quality of life at 1 year: Results from the Prospective Observational Study of TPIAT (POST) cohort

Author

Trikudanathan, Guru, primary, Eaton, Anne, additional, Abu-El-Haija, Maisam, additional, Adams, David, additional, Ahmad, Syed, additional, Beilman, Gregory J., additional, Chinnakotla, Srinath, additional, Downs, Elissa M., additional, Freeman, Martin L., additional, B. Gardner, Timothy, additional, Lara, Luis F., additional, Morgan, Katherine, additional, Mokshagundam, Sri Prakash, additional, Nathan, Jaimie D., additional, Naziruddin, Bashoo, additional, Posselt, Andrew, additional, Pruett, Timothy L., additional, Schwarzenberg, Sarah J., additional, Singh, Vikesh K., additional, Wijkstrom, Martin, additional, Witkowski, Piotr, additional, and Bellin, Melena D., additional

Published
2023
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85. A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

Author

Bellin, Melena D., Abu-El-Haija, Maisam, Morgan, Katherine, Adams, David, Beilman, Gregory J., Chinnakotla, Srinath, Conwell, Darwin L., Dunn, Ty B., Freeman, Martin L., Gardner, Timothy, Kirchner, Varvara A., Lara, Luis F., Long-Simpson, Leslie, Nathan, Jaimie D., Naziruddin, Bashoo, Nyman, John A., Pruett, Timothy L., Schwarzenberg, Sarah J., Singh, Vikesh K., Smith, Kerrington, Steel, Jennifer L., Wijkstrom, Martin, Witkowski, Piotr, and Hodges, James S.

Published
2018
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88. Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes

Author

Keymeulen, Bart, primary, De Groot, Kaat, additional, Jacobs-Tulleneers-Thevissen, Daniel, additional, Thompson, David M., additional, Bellin, Melena D., additional, Kroon, Evert J., additional, Daniels, Mark, additional, Wang, Richard, additional, Jaiman, Manasi, additional, Kieffer, Timothy J., additional, Foyt, Howard L., additional, and Pipeleers, Daniel, additional

Published
2023
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90. Case Report: Insulin hypersensitivity in youth with type 1 diabetes

Author

Alkhatib, Einas H., primary, Grundman, Jody B., additional, Adamusiak, Anna M., additional, Bellin, Melena D., additional, Brooks, Joel P., additional, Buckley, Kevin S., additional, Janssen, Erin M., additional, Kitcharoensakkul, Maleewan, additional, McNerney, Kyle P., additional, Pfeifer, Thea L., additional, Polk, Brooke I., additional, and Marks, Brynn E., additional

Published
2023
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92. Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations

Author

Giefer, Matthew J., Lowe, Mark E., Werlin, Steven L., Zimmerman, Bridget, Wilschanski, Michael, Troendle, David, Schwarzenberg, Sarah Jane, Pohl, John F., Palermo, Joseph, Ooi, Chee Y., Morinville, Veronique D., Lin, Tom K., Husain, Sohail Z., Himes, Ryan, Heyman, Melvin B., Gonska, Tanja, Gariepy, Cheryl E., Freedman, Steven D., Fishman, Douglas S., Bellin, Melena D., Barth, Bradley, Abu-El-Haija, Maisam, and Uc, Aliye

Published
2017
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94. Contributors

Author

Adachi, Tomohiko, primary, Adachi, Toshiyuki, additional, Alejandro, Rodolfo, additional, Alvarez, Ana M., additional, Alvaro, Domenico, additional, Andrei, Spencer R., additional, Armfield, Matthew, additional, Asthana, Amish, additional, Badylak, Stephen F., additional, Baidal, David A., additional, Balamurugan, Appakalai N., additional, Balzano, Gianpaolo, additional, Banerjee, Ipsita, additional, Barrera, Kaylene, additional, Bataller, Will, additional, Beilman, Greg J., additional, Bellin, Melena D., additional, Berman, Dora M., additional, Berry, Louise, additional, Bojar, Daniel, additional, Bottino, Rita, additional, Brigle, Nathaniel W., additional, Buchwald, Henry, additional, Buchwald, Jane N., additional, Cardinale, Vincenzo, additional, Carpino, Guido, additional, Cercone, Renee, additional, Chaimov, Deborah, additional, Chapman, Christopher G., additional, Child, Amanda, additional, Chinnakotla, Srinath, additional, Ciancio, Gaetano, additional, Colling, Kristin P., additional, Cook, Marie, additional, Cooper, David K.C., additional, Coughlan, Alexandria, additional, de Vries, Rick, additional, Domínguez-Bendala, Juan, additional, Dunn, Ty B., additional, Eguchi, Susumu, additional, Falconi, Massimo, additional, Feeney, Austin K., additional, Fontaine, Magali J., additional, Freedman, Benjamin S., additional, Fuenmayor, Virginia, additional, Fussenegger, Martin, additional, Gannon, Maureen, additional, Gauido, Eugenio, additional, Goedde, Michael A., additional, Gruessner, Rainer W.G., additional, Hermanns, Carolin, additional, Hidaka, Masaaki, additional, Hirabaru, Masataka, additional, Hughes, Michael G., additional, Hussain, Abid, additional, Imamura, Hajime, additional, Infante, Marco, additional, Janani, G., additional, Jetten, Marlon, additional, Jones, Christopher M., additional, Kalivarathan, Jagan, additional, Kanak, Mazhar A., additional, Kaplan, David L., additional, Kin, Tatsuya, additional, Kumar, Manishekhar, additional, Lakey, Jonathan R.T., additional, Lanzoni, Giacomo, additional, Larkin, Emily J., additional, Latres, Esther, additional, Lee, Yoojin C., additional, Linetsky, Elina, additional, Loganathan, Gopalakrishnan, additional, Maillard, Elisa, additional, Mandal, Biman B., additional, Martinez, Adela Helvia, additional, Matsushima, Hajime, additional, Matthews, Jeffrey B., additional, McEachron, Kendall, additional, Melzi, Raffaella, additional, Mercalli, Alessia, additional, Migliaccio, Giovanni, additional, Mitchell, Samantha A., additional, Mohammed, Sami, additional, Muir, Sean, additional, Nano, Rita, additional, Narayanan, Siddharth, additional, Natsuda, Koji, additional, Odorico, Jon S., additional, Ono, Shinichiro, additional, Orlando, Giuseppe, additional, Padilla, Nathalia, additional, Pellegrini, Silvia, additional, Perin, Laura, additional, Piemonti, Lorenzo, additional, Pileggi, Antonello, additional, Pineda Molina, Catalina, additional, Poli, Elizabeth C., additional, Qadir, Mirza Muhammad Fahd, additional, Ricordi, Camillo, additional, Rilo, L. Rodriguez, additional, Robertson, R. Paul, additional, Rust, William, additional, Sackett, Sara Dutton, additional, Saxena, Pratik, additional, Schwartzman, Alexander, additional, Schwarzenberg, Sarah J., additional, Sefton, Michael V., additional, Sharma, Sidharth, additional, Smood, Benjamin, additional, Socci, Davide, additional, Sordi, Valeria, additional, Stell, Adam, additional, Stock, Aaron A., additional, Takatsuki, Mitsuhisa, additional, Tomei, Alice A., additional, Tremmel, Daniel M., additional, Tuch, Bernard E., additional, Vaithilingam, Vijayaganapathy, additional, van Apeldoorn, Aart, additional, Villani, Valentina, additional, Vlahos, Alexander E., additional, Williams, Stuart K., additional, Xiao, Xiangwei, additional, Yadav, Kunal, additional, Yamashita, Manpei, additional, and Zulewski, Henryk, additional

Published
2020
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95. Long-term results of TPIAT

Author

McEachron, Kendall, primary, Coughlan, Alexandria, additional, Cook, Marie, additional, Berry, Louise, additional, Beilman, Greg J., additional, and Bellin, Melena D., additional

Published
2020
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100. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data from the INSPPIRE Cohort

Author

Bellin, Melena D., Lowe, Mark, Zimmerman, M. Bridget, Wilschanski, Michael, Werlin, Steven, Troendle, David M., Shah, Uzma, Schwarzenberg, Sarah J., Pohl, John F., Perito, Emily, Ooi, Chee Yee, Nathan, Jaimie D., Morinville, Veronique D., McFerron, Brian A., Mascarenhas, Maria R., Maqbool, Asim, Liu, Quin, Lin, Tom K., Husain, Sohail Z., Himes, Ryan, Heyman, Melvin B., Gonska, Tanja, Giefer, Matthew J., Gariepy, Cheryl E., Freedman, Steven D., Fishman, Douglas S., Barth, Bradley, Abu-El-Haija, Maisam, and Uc, Aliye

Published
2019
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