5,712 results on '"Baxendale A."'
Search Results
52. Further investigations into imine-mediated formation of allylic nitro compounds
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Sharley, James S., Gambacorta, Guido, Collado Pérez, Ana María, Ferri, Estela Espinos, Miranda, Amadeo Fernandez, Quesada, Jorge Sanchez, and Baxendale, Ian R.
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- 2022
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53. Detection of Giardia and helminths in Western Europe at local K9 (canine) sites (DOGWALKS Study)
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Jason Drake, Sarah Sweet, Kingsley Baxendale, Evan Hegarty, Stephanie Horr, Hanne Friis, Troy Goddu, William G. Ryan, and Georg von Samson-Himmelstjerna
- Subjects
Ascarid ,Centrifugal flotation ,Coproantigen ,Dog ,Europe ,Giardia ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Intestinal parasite contamination from infected dogs can place other dogs and humans at risk. A study was initiated to estimate the prevalence of canine intestinal parasitism by collecting fecal samples in cities across Western Europe. Methods Fresh fecal samples were collected from 2469 dogs visiting 164 parks in 33 cities across 12 countries. Each owner responded to a questionnaire focusing on their dog’s signalment and recent anthelmintic treatment history. The collected samples were examined for hookworms, whipworms, ascarids and Giardia using a coproantigen diagnostic immunoassay and microscopy following centrifugal flotation. Results Nematodes or Giardia were detected in at least one sample from 100% of cities and in 93.3% of parks. Nematodes were detected in 57% of parks. Overall, 22.8% of dogs tested positive for an intestinal parasite, with Giardia being the most commonly identified parasites (17.3% of dogs, 83.5% of parks). For nematode infection, 7.6% of all dogs tested positive, with 9.9% of dogs aged 1 month had passed since the previous dose. Conclusions The prevalence estimates of intestinal parasite infections in dogs reported here highlight the need for owner education concerning guidelines for regular testing and treatment, even in older dogs. Failure to adhere to guidelines can result in ongoing transmission of these infections, including those with zoonotic potential. Combining coproantigen immunoassay with centrifugal flotation for diagnostic testing and regular anthelmintic treatment are important measures for ensuring optimal intestinal parasite control. Graphical Abstract
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- 2022
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54. GENESISS 2—Generating Standards for In-Situ Simulation project: a systematic mapping review
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Kerry Evans, Jenny Woodruff, Alison Cowley, Louise Bramley, Giulia Miles, Alastair Ross, Joanne Cooper, and Bryn Baxendale
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In-situ simulation ,simulation-based education ,Clinical training ,Simulated practice ,Health professions ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background In-situ simulation is increasingly employed in healthcare settings to support learning and improve patient, staff and organisational outcomes. It can help participants to problem solve within real, dynamic and familiar clinical settings, develop effective multidisciplinary team working and facilitates learning into practice. There is nevertheless a reported lack of a standardised and cohesive approach across healthcare organisations. The aim of this systematic mapping review was to explore and map the current evidence base for in-situ interventions, identify gaps in the literature and inform future research and evaluation questions. Methods A systematic mapping review of published in-situ simulation literature was conducted. Searches were conducted on MEDLINE, EMBASE, AMED, PsycINFO, CINAHL, MIDIRS and ProQuest databases to identify all relevant literature from inception to October 2020. Relevant papers were retrieved, reviewed and extracted data were organised into broad themes. Results Sixty-nine papers were included in the mapping review. In-situ simulation is used 1) as an assessment tool; 2) to assess and promote system readiness and safety cultures; 3) to improve clinical skills and patient outcomes; 4) to improve non-technical skills (NTS), knowledge and confidence. Most studies included were observational and assessed individual, team or departmental performance against clinical standards. There was considerable variation in assessment methods, length of study and the frequency of interventions. Conclusions This mapping highlights various in-situ simulation approaches designed to address a range of objectives in healthcare settings; most studies report in-situ simulation to be feasible and beneficial in addressing various learning and improvement objectives. There is a lack of consensus for implementing and evaluating in-situ simulation and further studies are required to identify potential benefits and impacts on patient outcomes. In-situ simulation studies need to include detailed demographic and contextual data to consider transferability across care settings and teams and to assess possible confounding factors. Valid and reliable data collection tools should be developed to capture the complexity of team and individual performance in real settings. Research should focus on identifying the optimal frequency and length of in-situ simulations to improve outcomes and maximize participant experience.
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- 2022
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55. Noise Sharing and Mexican Hat Coupling in a Stochastic Neural Field
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Baxendale, Peter H., Greenwood, Priscilla E., and Ward, Lawrence M.
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Quantitative Biology - Neurons and Cognition - Abstract
A diffusion-type coupling operator biologically significant in neuroscience is a difference of Gaussian functions (Mexican Hat operator) used as a spatial-convolution kernel. We are interested in pattern formation by \emph{stochastic} neural field equations, a class of space-time stochastic differential-integral equations using the Mexican Hat kernel. We explore, quantitatively, how the parameters that control the shape of the coupling kernel, coupling strength, and aspects of spatially-smoothed space-time noise, influence the pattern in the resulting evolving random field. We confirm that a spatial pattern that is damped in time in a deterministic system may be sustained and amplified by stochasticity. We find that spatially-smoothed noise alone causes pattern formation even without direct spatial coupling. Our analysis of the interaction between coupling and noise sharing allows us to determine parameter combinations that are optimal for the formation of spatial pattern., Comment: 17 pages, 7 figures
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- 2018
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56. Atlas regionales con Sistemas de Información Geográfica en la generación de resultados de transferencia.
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Buzai, Gustavo D., primary, Lanzelotti, Sonia L., additional, Principi, Noelia, additional, Galbán, Eloy Montes, additional, Humacata, Luis, additional, Suárez, Gabriel Acuña, additional, and Baxendale, Claudia A., additional
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- 2022
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57. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
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Evans, R A, Leavy, O C, Richardson, M, Elneima, O, McAuley, H J C, Shikotra, A, Singapuri, A, Sereno, M, Saunders, R M, Harris, V C, Houchen-Wolloff, L, Aul, R, Beirne, P, Bolton, C E, Brown, J S, Choudhury, G, Diar-Bakerly, N, Easom, N, Echevarria, C, Fuld, J, Hart, N, Hurst, J, Jones, M G, Parekh, D, Pfeffer, P, Rahman, N M, Rowland-Jones, S L, Shah, A M, Wootton, D G, Chalder, T, Davies, M J, De Soyza, A, Geddes, J R, Greenhalf, W, Greening, N J, Heaney, L G, Heller, S, Howard, L S, Jacob, J, Jenkins, R G, Lord, J M, Man, W D-C, McCann, G P, Neubauer, S, Openshaw, P J M, Porter, J C, Rowland, M J, Scott, J T, Semple, M G, Singh, S J, Thomas, D C, Toshner, M, Lewis, K E, Thwaites, R S, Briggs, A, Docherty, A B, Kerr, S, Lone, N I, Quint, J, Sheikh, A, Thorpe, M, Zheng, B, Chalmers, J D, Ho, L P, Horsley, A, Marks, M, Poinasamy, K, Raman, B, Harrison, E M, Wain, L V, Brightling, C E, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, N, Ahmed, R, Ahwireng, N, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Ali, M, Aljaroof, M, All, AM, Allan, L, Allen, R J, Allerton, L, Allsop, L, Almeida, P, Altmann, D, Alvarez Corral, M, Amoils, S, Anderson, D, Antoniades, C, Arbane, G, Arias, A, Armour, C, Armstrong, L, Armstrong, N, Arnold, D, Arnold, H, Ashish, A, Ashworth, A, Ashworth, M, Aslani, S, Assefa-Kebede, H, Atkin, C, Atkin, P, Aung, H, Austin, L, Avram, C, Ayoub, A, Babores, M, Baggott, R, Bagshaw, J, Baguley, D, Bailey, L, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Banerjee, A, Bang, B, Barker, R E, Barman, L, Barratt, S, Barrett, F, Basire, D, Basu, N, Bates, M, Bates, A, Batterham, R, Baxendale, H, Bayes, H, Beadsworth, M, Beckett, P, Beggs, M, Begum, M, Bell, D, Bell, R, Bennett, K, Beranova, E, Bermperi, A, Berridge, A, Berry, C, Betts, S, Bevan, E, Bhui, K, Bingham, M, Birchall, K, Bishop, L, Bisnauthsing, K, Blaikely, J, Bloss, A, Bolger, A, Bonnington, J, Botkai, A, Bourne, C, Bourne, M, Bramham, K, Brear, L, Breen, G, Breeze, J, Bright, E, Brill, S, Brindle, K, Broad, L, Broadley, A, Brookes, C, Broome, M, Brown, A, Brown, J, Brown, M, Brown, V, Brugha, T, Brunskill, N, Buch, M, Buckley, P, Bularga, A, Bullmore, E, Burden, L, Burdett, T, Burn, D, Burns, G, Burns, A, Busby, J, Butcher, R, Butt, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Carborn, H, Card, B, Carr, C, Carr, L, Carson, G, Carter, P, Casey, A, Cassar, M, Cavanagh, J, Chablani, M, Chambers, R C, Chan, F, Channon, K M, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Cheng, Y, Chetham, L, Childs, C, Chilvers, E R, Chinoy, H, Chiribiri, A, Chong-James, K, Choudhury, N, Chowienczyk, P, Christie, C, Chrystal, M, Clark, D, Clark, C, Clarke, J, Clohisey, S, Coakley, G, Coburn, Z, Coetzee, S, Cole, J, Coleman, C, Conneh, F, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Cooper, J, Cooper, S, Copeland, D, Cosier, T, Coulding, M, Coupland, C, Cox, E, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Cuthbertson, D, Daines, L, Dalton, M, Daly, P, Daniels, A, Dark, P, Dasgin, J, David, A, David, C, Davies, E, Davies, F, Davies, G, Davies, G A, Davies, K, Dawson, J, Daynes, E, Deakin, B, Deans, A, Deas, C, Deery, J, Defres, S, Dell, A, Dempsey, K, Denneny, E, Dennis, J, Dewar, A, Dharmagunawardena, R, Dickens, C, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, S L, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Draxlbauer, K, Drury, K, Dulawan, P, Dunleavy, A, Dunn, S, Earley, J, Edwards, S, Edwardson, C, El-Taweel, H, Elliott, A, Elliott, K, Ellis, Y, Elmer, A, Evans, D, Evans, H, Evans, J, Evans, R, Evans, R I, Evans, T, Evenden, C, Evison, L, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Fayzan, T, Featherstone, J, Felton, T, Finch, J, Finney, S, Finnigan, J, Finnigan, L, Fisher, H, Fletcher, S, Flockton, R, Flynn, M, Foot, H, Foote, D, Ford, A, Forton, D, Fraile, E, Francis, C, Francis, R, Francis, S, Frankel, A, Fraser, E, Free, R, French, N, Fu, X, Furniss, J, Garner, L, Gautam, N, George, J, George, P, Gibbons, M, Gill, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Goodwin, C, Gooptu, B, Gordon, H, Gorsuch, T, Greatorex, M, Greenhaff, P L, Greenhalgh, A, Greenwood, J, Gregory, H, Gregory, R, Grieve, D, Griffin, D, Griffiths, L, Guerdette, A-M, Guillen Guio, B, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Guy, Z, H Henson, H, Hadley, K, Haggar, A, Hainey, K, Hairsine, B, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hancock, A, Hancock, K, Hanley, N A, Haq, S, Hardwick, H E, Hardy, E, Hardy, T, Hargadon, B, Harrington, K, Harris, E, Harrison, P, Harvey, A, Harvey, M, Harvie, M, Haslam, L, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Haynes, M, Hazeldine, J, Hazelton, T, Heeley, C, Heeney, J L, Heightman, M, Henderson, M, Hesselden, L, Hewitt, M, Highett, V, Hillman, T, Hiwot, T, Hoare, A, Hoare, M, Hockridge, J, Hogarth, P, Holbourn, A, Holden, S, Holdsworth, L, Holgate, D, Holland, M, Holloway, L, Holmes, K, Holmes, M, Holroyd-Hind, B, Holt, L, Hormis, A, Hosseini, A, Hotopf, M, Howard, K, Howell, A, Hufton, E, Hughes, A D, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurditch, E, Husain, M, Hussell, T, Hutchinson, J, Ibrahim, W, Ilyas, F, Ingham, J, Ingram, L, Ionita, D, Isaacs, K, Ismail, K, Jackson, T, James, W Y, Jarman, C, Jarrold, I, Jarvis, H, Jastrub, R, Jayaraman, B, Jezzard, P, Jiwa, K, Johnson, C, Johnson, S, Johnston, D, Jolley, C J, Jones, D, Jones, G, Jones, H, Jones, I, Jones, L, Jones, S, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kanellakis, N, Kaprowska, s, Kausar, Z, Keenan, N, Kelly, S, Kemp, G, Kerslake, H, Key, A L, Khan, F, Khunti, K, Kilroy, S, King, B, King, C, Kingham, L, Kirk, J, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O, Kon, S, Kon, S S, Koprowska, S, Korszun, A, Koychev, I, Kurasz, C, Kurupati, P, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lavelle-Langham, L, Lawrie, A, Lawson, C, Layton, A, Lea, A, Lee, D, Lee, J-H, Lee, E, Leitch, K, Lenagh, R, Lewis, D, Lewis, J, Lewis, V, Lewis-Burke, N, Li, X, Light, T, Lightstone, L, Lilaonitkul, W, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Loosley, R, Lota, H, Lovegrove, W, Lucey, A, Lukaschuk, E, Lye, A, Lynch, C, MacDonald, S, MacGowan, G, Macharia, I, Mackie, J, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Magtoto, M M, Mairs, N, Majeed, N, Major, E, Malein, F, Malim, M, Mallison, G, Mandal, S, Mangion, K, Manisty, C, Manley, R, March, K, Marciniak, S, Marino, P, Mariveles, M, Marouzet, E, Marsh, S, Marshall, B, Marshall, M, Martin, J, Martineau, A, Martinez, L M, Maskell, N, Matila, D, Matimba-Mupaya, W, Matthews, L, Mbuyisa, A, McAdoo, S, Weir McCall, J, McAllister-Williams, H, McArdle, A, McArdle, P, McAulay, D, McCormick, J, McCormick, W, McCourt, P, McGarvey, L, McGee, C, Mcgee, K, McGinness, J, McGlynn, K, McGovern, A, McGuinness, H, McInnes, I B, McIntosh, J, McIvor, E, McIvor, K, McLeavey, L, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McNeill, J, McQueen, A, McShane, H, Mears, C, Megson, C, Megson, S, Mehta, P, Meiring, J, Melling, L, Mencias, M, Menzies, D, Merida Morillas, M, Michael, A, Milligan, L, Miller, C, Mills, C, Mills, N L, Milner, L, Misra, S, Mitchell, J, Mohamed, A, Mohamed, N, Mohammed, S, Molyneaux, P L, Monteiro, W, Moriera, S, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A J, Moss, P, Motohashi, K, Msimanga, N, Mukaetova-Ladinska, E, Munawar, U, Murira, J, Nanda, U, Nassa, H, Nasseri, M, Neal, A, Needham, R, Neill, P, Newell, H, Newman, T, Newton-Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Norman, C, Novotny, P, Nunag, J, Nwafor, L, Nwanguma, U, Nyaboko, J, O'Donnell, K, O'Brien, C, O'Brien, L, O'Regan, D, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Orriss-Dib, L, Osborne, L, Osbourne, R, Ostermann, M, Overton, C, Owen, J, Oxton, J, Pack, J, Pacpaco, E, Paddick, S, Painter, S, Pakzad, A, Palmer, S, Papineni, P, Paques, K, Paradowski, K, Pareek, M, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Patale, S, Patel, B, Patel, M, Patel, S, Pattenadk, D, Pavlides, M, Payne, S, Pearce, L, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peterkin, Z, Peto, T, Petousi, N, Petrie, J, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plant, H, Plein, S, Plekhanova, T, Plowright, M, Polgar, O, Poll, L, Porter, J, Portukhay, S, Powell, N, Prabhu, A, Pratt, J, Price, A, Price, C, Price, D, Price, L, Prickett, A, Propescu, J, Pugmire, S, Quaid, S, Quigley, J, Qureshi, H, Qureshi, I N, Radhakrishnan, K, Ralser, M, Ramos, A, Ramos, H, Rangeley, J, Rangelov, B, Ratcliffe, L, Ravencroft, P, Reddington, A, Reddy, R, Redfearn, H, Redwood, D, Reed, A, Rees, M, Rees, T, Regan, K, Reynolds, W, Ribeiro, C, Richards, A, Richardson, E, Rivera-Ortega, P, Roberts, K, Robertson, E, Robinson, E, Robinson, L, Roche, L, Roddis, C, Rodger, J, Ross, A, Ross, G, Rossdale, J, Rostron, A, Rowe, A, Rowland, A, Rowland, J, Roy, K, Roy, M, Rudan, I, Russell, R, Russell, E, Saalmink, G, Sabit, R, Sage, E K, Samakomva, T, Samani, N, Sampson, C, Samuel, K, Samuel, R, Sanderson, A, Sapey, E, Saralaya, D, Sargant, J, Sarginson, C, Sass, T, Sattar, N, Saunders, K, Saunders, P, Saunders, L C, Savill, H, Saxon, W, Sayer, A, Schronce, J, Schwaeble, W, Scott, K, Selby, N, Sewell, T A, Shah, K, Shah, P, Shankar-Hari, M, Sharma, M, Sharpe, C, Sharpe, M, Shashaa, S, Shaw, A, Shaw, K, Shaw, V, Shelton, S, Shenton, L, Shevket, K, Short, J, Siddique, S, Siddiqui, S, Sidebottom, J, Sigfrid, L, Simons, G, Simpson, J, Simpson, N, Singh, C, Singh, S, Sissons, D, Skeemer, J, Slack, K, Smith, A, Smith, D, Smith, S, Smith, J, Smith, L, Soares, M, Solano, T S, Solly, R, Solstice, AR, Soulsby, T, Southern, D, Sowter, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steele, N, Steiner, M, Stensel, D, Stephens, G, Stephenson, L, Stern, M, Stewart, I, Stimpson, R, Stockdale, S, Stockley, J, Stoker, W, Stone, R, Storrar, W, Storrie, A, Storton, K, Stringer, E, Strong-Sheldrake, S, Stroud, N, Subbe, C, Sudlow, C L, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Tarusan, L, Tavoukjian, V, Taylor, A, Taylor, C, Taylor, J, Te, A, Tedd, H, Tee, CJ, Teixeira, J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thamu, B, Thickett, D, Thomas, C, Thomas, S, Thomas, A K, Thomas-Woods, T, Thompson, T, Thompson, A A R, Thornton, T, Tilley, J, Tinker, N, Tiongson, G F, Tobin, M, Tomlinson, J, Tong, C, Touyz, R, Tripp, K A, Tunnicliffe, E, Turnbull, A, Turner, E, Turner, S, Turner, V, Turner, K, Turney, S, Turtle, L, Turton, H, Ugoji, J, Ugwuoke, R, Upthegrove, R, Valabhji, J, Ventura, M, Vere, J, Vickers, C, Vinson, B, Wade, E, Wade, P, Wainwright, T, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, J A, Walsh, S, Warburton, L, Ward, T J C, Warwick, K, Wassall, H, Waterson, S, Watson, E, Watson, L, Watson, J, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Weston, H, Wheeler, H, White, S, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Whitworth, V, Wight, A, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Willoughby, J, Wilson, A, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Wood, C, Woodhead, F, Woods, J, Wormleighton, J, Worsley, J, Wraith, D, Wrey Brown, C, Wright, C, Wright, L, Wright, S, Wyles, J, Wynter, I, Xu, M, Yasmin, N, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Zawia, A, Zeidan, L, Zhao, B, and Zongo, O
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- 2022
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58. How to be a Better Doctor: Recognizing How Cognitive Biases Shape—and Distort—Clinical Evidence.
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Baxendale, Sallie
- Abstract
Rather than the absence of any harm, it is the expectation of an overall benefit of a medical treatment that is the foundation of the implicit doctor-patient contract. In the context of an expectation of efficacy, powerful cognitive biases can blind clinicians to obvious signs that a treatment is not helping, or may even be harming their patients. With examples from medical history and current clinical controversies, this paper examines how systematic psychological biases can distort not just individual decision making, but perceptions of the evidence base upon which clinical decisions are built. These distortions can perpetuate harmful practices in medicine long after the objective evidence points in a different direction. By becoming aware of these biases and the way they shape perceptions of the evidence base, doctors can reduce the negative impact they may have on the patients in their care. [ABSTRACT FROM AUTHOR]
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- 2025
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59. Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection.
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Fleury, Marine N., Binding, Lawrence P., Taylor, Peter, Xiao, Fenglai, Giampiccolo, Davide, Buck, Sarah, Winston, Gavin P., Thompson, Pamela J., Baxendale, Sallie, McEvoy, Andrew W., Koepp, Matthias J., Duncan, John S., and Sidhu, Meneka K.
- Abstract
Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery. We assess memory network changes, from 3–12 months to 10 years postoperatively, in 25 patients (12 left-sided resections) relative to 10 healthy matched controls, using longitudinal task-based functional MRI and standard neuropsychology assessments. We observe key adaptive changes in memory networks of a predominantly seizure-free cohort. Ongoing neuroplasticity in posterior medial temporal regions and contralesional cingulum or pallidum contribute to long-term verbal and visual memory recovery. Here, we show the potential for sustained cognitive improvement and importance of strategic approaches in epilepsy treatment, advocating for conservative surgeries and long-term use of cognitive rehabilitation for ongoing recovery.Using functional MRI, the authors tracked memory recovery over a decade after epilepsy surgery, revealing key brain changes in spared medial temporal structures and contralateral regions, highlighting neural mechanisms behind sustained improvement. [ABSTRACT FROM AUTHOR]
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- 2025
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60. Preoperative predictors of postoperative satisfaction with surgery
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Cook, Charlotte and Baxendale, Sallie
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- 2022
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61. GENESISS 1—Generating Standards for In-Situ Simulation project: a scoping review and conceptual model
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Bryn Baxendale, Kerry Evans, Alison Cowley, Louise Bramley, Guilia Miles, Alastair Ross, Eleanore Dring, and Joanne Cooper
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In-situ simulation ,Simulation-based education ,Clinical training ,Simulated practice ,Health professions ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background In-Situ Simulation (ISS) enables teams to rehearse and review practice in the clinical environment to facilitate knowledge transition, reflection and safe learning. There is increasing use of ISS in healthcare organisations for which patient safety and quality improvement are key drivers. However, the effectiveness of ISS interventions has not yet been fully demonstrated and requires further study to maximise impact. Cohesive programmatic implementation is lacking and efforts to standardise ISS terms and concepts, strengthen the evidence base and develop an integrated model of learning is required. The aim of this study was to explore the current evidence, theories and concepts associated with ISS across all areas of healthcare and develop a conceptual model to inform future ISS research and best practice guidance. Methods A scoping review was undertaken with stakeholder feedback to develop a conceptual model for ISS. Medline, OpenGrey and Web of Science were searched in September 2018 and updated in December 2020. Data from the included scoping review studies were analysed descriptively and organised into categories based on the different motivations, concepts and theoretical approaches for ISS. Categories and concepts were further refined through accessing stakeholder feedback. Results Thirty-eight papers were included in the scoping review. Papers reported the development and evaluation of ISS interventions. Stakeholder groups highlighted situations where ISS could be suitable to improve care and outcomes and identified contextual and practical factors for implementation. A conceptual model of ISS was developed which was organised into four themes: 1. To understand and explore why systematic events occur in complex settings; 2.To design and test new clinical spaces, equipment, information technologies and procedures; 3. To practice and develop capability in individual and team performance; 4. To assess competency in complex clinical settings. Conclusions ISS presents a promising approach to improve individual and team capabilities and system performance and address the ‘practice-theory gap’. However, there are limitations associated with ISS such as the impact on the clinical setting and service provision, the reliance of having an open learning culture and availability of relevant expertise. ISS should be introduced with due consideration of the specific objectives and learning needs it is proposed to address. Effectiveness of ISS has not yet been established and further research is required to evaluate and disseminate the findings of ISS interventions.
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- 2022
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62. Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients
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Diego Cantoni, Martin Mayora-Neto, Nazia Thakur, Ahmed M. E. Elrefaey, Joseph Newman, Sneha Vishwanath, Angalee Nadesalingam, Andrew Chan, Peter Smith, Javier Castillo-Olivares, Helen Baxendale, Bryan Charleston, Jonathan Heeney, Dalan Bailey, and Nigel Temperton
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Biology (General) ,QH301-705.5 - Abstract
Bat Coronavirus RaTG13, a sarbecovirus related to SARS-CoV-2, is more potently neutralized by antibodies from convalescent SARS-CoV-2-infected patients as well as vaccinated healthcare workers despite the spike proteins having high diversity within their receptor binding domains (RBD).
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- 2022
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63. Treatment of chronic or relapsing COVID-19 in immunodeficiency
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Brown, Li-An K., Moran, Ed, Goodman, Anna, Baxendale, Helen, Bermingham, William, Buckland, Matthew, AbdulKhaliq, Iman, Jarvis, Hannah, Hunter, Michael, Karanam, Surendra, Patel, Aisha, Jenkins, Megan, Robbins, Alexander, Khan, Sujoy, Simpson, Thomas, Jolles, Stephen, Underwood, Jonathan, Savic, Sinisa, Richter, Alex, Shields, Adrian, Brown, Michael, and Lowe, David M.
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- 2022
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64. Land Body Ecologies: A case study for global transdisciplinary collaboration at the intersections of environment and mental health
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Samrawit Gougsa, Victoria Pratt, Babitha George, Cecilia Vilela, Daniel Kobei, Sylvia Kokunda, Ilan Kelman, Ben Eaton, Lilian Maina, Samson Luari, Outi Autti, Kaisa Kerätär, Jenni Laiti, Catherine Baxendale, Romit Raj, Reema Deshpande, Riya Gokharu, Neha Singh, Sheila Ghelani, Nqatyiswa Mendu, and Ayesha Ahmad
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Transdisciplinary research ,Mental health ,Climate change ,Solastalgia ,Creative methodologies ,Environment ,Public aspects of medicine ,RA1-1270 ,Meteorology. Climatology ,QC851-999 - Abstract
Land Body Ecologies (LBE) is a global, transdisciplinary research group seeking to understand the mental health dimensions of minority, Indigenous and other land-dependent communities’ relationship to ecologies in a changing environment. We posit that our project is a successful case of global transdisciplinary collaboration that can serve as an example for others. In this paper we present: (1) an overview of our project structure across various disciplines and geographies; (2) a description of how we manage day-to-day operations and decision-making; (3) details of how we operationalise collaboration through examples from three key areas – creative methodologies, language considerations and authorship; (4) a discussion on strengths and limitations of the project.
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- 2023
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65. Spectroscopic dataset of Hedione's derivatives gathered during process development
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James S. Sharley, Guido Gambacorta, Ana María Collado Pérez, Estela Espinos Ferri, Amadeo Fernandez Miranda, Jorge Sanchez Quesada, and Ian R. Baxendale
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Hedione ,Chlorination ,Dehydrohedione ,NMR ,Fluorination ,Accurate mass ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
The dataset of spectroscopic analysis performed on starting materials, intermediates, and products relating to the synthesis of Hedione are hereby presented. The data were acquired in Durham university during the period between October 2020 and September 2021 for the development of a preparative method to Dehydrohedione. The latter is a key intermediate for the synthesis of cis-Hedione, an important fragrance ingredient. Proton, Carbon-13, and Fluorine-19 Nuclear magnetic resonance of the compounds were recorded employing a Varian 600 MHz, and a Bruker Avance-400 instrument. The IR spectra were recorded in a Perkin Elmer Spectrum Two UATR Two FT-IR and the accurate mass employing a Waters QtoF premier as mass spectrometer.
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- 2023
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66. Editorial
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Sallie Baxendale
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Neurology. Diseases of the nervous system ,RC346-429 ,Neurophysiology and neuropsychology ,QP351-495 - Published
- 2023
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67. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
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Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adeyemi, F, Ahmad, S, Ahmed, R, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Aljaroof, M, Allan, L, Allen, R, Alli, A, Altmann, D, Anderson, D, Andrews, M, Angyal, A, Antoniades, C, Arbane, G, Armour, C, Armstrong, N, Armstrong, L, Arnold, H, Arnold, D, Ashworth, M, Ashworth, A, Assefa-Kebede, H, Atkin, P, Atkins, H, Atkins, A, Aul, R, Avram, C, Baggott, R, Baguley, D, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Bambrough, J, Barker, R E, Barratt, S, Barrett, F, Basire, D, Basu, N, Batterham, R, Baxendale, H, Bayes, H, Bayley, M, Beadsworth, M, Beirne, P, Bell, R, Bell, D, Berry, C, Betts, S, Bhui, K, Bishop, L, Blaikely, J, Bloomfield, C, Bloss, A, Bolger, A, Bolton, C E, Bonnington, J, Botkai, A, Bourne, M, Bourne, C, Bradley, E, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brightling, C E, Brill, S, Brindle, K, Broad, L, Broome, M, Brown, J S, Brown, M, Brown, J, Brown, R, Brown, V, Brown, A, Brugha, T, Brunskill, N, Buch, M, Bularga, A, Bullmore, E, Burn, D, Burns, G, Busby, J, Buttress, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Card, B, Carr, L, Carson, G, Carter, P, Cavanagh, J, Chalder, T, Chalmers, J D, Chambers, R C, Channon, K, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Chetham, L, Chilvers, E R, Chinoy, H, Chong-James, K, Choudhury, N, Choudhury, G, Chowdhury, P, Chowienczyk, P, Christie, C, Clark, D, Clark, C, Clarke, J, Clift, P, Clohisey, S, Coburn, Z, Cole, J, Coleman, C, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Coupland, C, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Daines, L, Dalton, M, Dark, P, Dasgin, J, David, A, David, C, Davies, M, Davies, G, Davies, K, Davies, F, Davies, G A, Daynes, E, De Silva, T, De Soyza, A, Deakin, B, Deans, A, Defres, S, Dell, A, Dempsey, K, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar Bakerly, N, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, C, Dobson, S L, Docherty, A B, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Dulawan, P, Dunleavy, A, Dunn, S, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, Elliott, B, Elliott, A, Ellis, Y, Elmer, A, Elneima, O, Evans, R A, Evans, J, Evans, H, Evans, D, Evans, R I, Evans, R, Evans, T, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Felton, T, Finch, J, Finney, S, Fisher, H, Fletcher, S, Flockton, R, Foote, D, Ford, A, Forton, D, Francis, R, Francis, S, Francis, C, Frankel, A, Fraser, E, Free, R, French, N, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, P M, George, J, Gibbons, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Gooptu, B, Gorsuch, T, Gourlay, E, Greenhaff, P, Greenhalf, W, Greenhalgh, A, Greening, N J, Greenwood, J, Greenwood, S, Gregory, R, Grieve, D, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Hadley, K, Haggar, A, Hainey, K, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hanley, N A, Hardwick, H E, Hardy, E, Hargadon, B, Harrington, K, Harris, V, Harrison, E M, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Heaney, L G, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hillman, T, Hingorani, A, Hiwot, T, Ho, L P, Hoare, A, Hoare, M, Hogarth, P, Holbourn, A, Holdsworth, L, Holgate, D, Holmes, K, Holroyd-Hind, B, Horsley, A, Hosseini, A, Hotopf, M, Houchen, L, Howard, L, Howell, A, Hufton, E, Hughes, A, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurst, J R, Hurst, R, Husain, M, Hussell, T, Ibrahim, W, Ient, A, Ingram, L, Ismail, K, Jackson, T, Jacob, J, James, W Y, Janes, S, Jarvis, H, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, S, Johnson, C, Johnston, D, Jolley, C, Jolley, C J, Jones, I, Jones, S, Jones, D, Jones, H, Jones, G, Jones, M, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kar, P, Kausar, Z, Kelly, S, Kerr, S, Key, A L, Khan, F, Khunti, K, King, C, King, B, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O M, Kon, S, Kon, S S, Korszun, A, Kotanidis, C, Koychev, I, Kurupati, P, Kwan, J, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lawrie, A, Lea, A, Leavy, O C, Lee, D, Lee, E, Leitch, K, Lenagh, R, Lewis, K, Lewis, V, Lewis, K E, Lewis, J, Lewis-Burke, N, Light, T, Lightstone, L, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Lone, N I, Loosley, R, Lord, J M, Lota, H, Lucey, A, MacGowan, G, Macharia, I, Mackay, C, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Mairs, N, Majeed, N, Major, E, Malim, M, Mallison, G, Man, W, Mandal, S, Mangion, K, Mansoori, P, Marciniak, S, Mariveles, M, Marks, M, Marshall, B, Martineau, A, Maskell, N, Matila, D, Matthews, L, Mayet, J, McAdoo, S, McAllister-Williams, H, McArdle, P, McArdle, A, McAulay, D, McAuley, H J C, McAuley, D F, McCafferty, K, McCann, G P, McCauley, H, McCourt, P, Mcgarvey, L, McGinness, J, McGovern, A, McGuinness, H, McInnes, I B, McIvor, K, McIvor, E, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McQueen, A, McShane, H, Megson, S, Meiring, J, Menzies, D, Michael, A, Michael, B D, Milligan, L, Mills, N, Mitchell, J, Mohamed, A, Molyneaux, P L, Monteiro, W, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A, Moss, A J, Moss, P, Mukaetova-Ladinska, E, Munawar, U, Murali, E, Murira, J, Nassa, H, Neill, P, Neubauer, S, Newby, D, Newell, H, Newton Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Novotny, P, Nunag, J, Nyaboko, J, O'Brien, L, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Openshaw, P J M, Osbourne, R, Ostermann, M, Overton, C, Oxton, J, Pacpaco, E, Paddick, S, Papineni, P, Paradowski, K, Pareek, M, Parekh, D, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Parvin, R, Patale, S, Patel, B, Patel, S, Patel, M, Pathmanathan, B, Pavlides, M, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peto, T, Petousi, N, Petrie, J, Pfeffer, P, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plein, S, Plekhanova, T, Poinasamy, K, Polgar, O, Poll, L, Porter, J C, Portukhay, S, Powell, N, Price, L, Price, D, Price, A, Price, C, Prickett, A, Quaid, S, Quigley, J, Quint, J, Qureshi, H, Rahman, N, Rahman, M, Ralser, M, Raman, B, Ramos, A, Rangeley, J, Rees, T, Regan, K, Richards, A, Richardson, M, Rivera-Ortega, P, Robertson, E, Rodgers, J, Ross, G, Rossdale, J, Rostron, A, Routen, A, Rowland, A, Rowland, M J, Rowland, J, Rowland-Jones, S L, Roy, K, Rudan, I, Russell, R, Russell, E, Sabit, R, Sage, E K, Samani, N, Samuel, R, Sapey, E, Saralaya, D, Saratzis, A, Sargeant, J, Sass, T, Sattar, N, Saunders, K, Saunders, R, Saxon, W, Sayer, A, Schwaeble, W, Scott, J, Scott, K, Selby, N, Semple, M G, Sereno, M, Shah, K, Shah, A, Shah, P, Sharma, M, Sharpe, M, Sharpe, C, Shaw, V, Sheikh, A, Shevket, K, Shikotra, A, Short, J, Siddiqui, S, Sigfrid, L, Simons, G, Simpson, J, Singapuri, A, Singh, S J, Singh, C, Singh, S, Skeemer, J, Smith, I, Smith, J, Smith, L, Smith, A, Soares, M, Southern, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steiner, M, Stensel, D, Stern, M, Stewart, I, Stockley, J, Stone, R, Storrie, A, Storton, K, Stringer, E, Subbe, C, Sudlow, C, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Taylor, C, Taylor, A, Te, A, Tedd, H, Tee, C J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thickett, D, Thomas, D, Thomas, D C, Thomas, A K, Thompson, A A R, Thompson, T, Thornton, T, Thwaites, R S, Tobin, M, Toingson, G F, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turner, E, Turtle, L, Turton, H, Ugwuoke, R, Upthegrove, R, Valabhji, J, Vellore, K, Wade, E, Wain, L V, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, S, Walsh, J A, Watson, L, Watson, J, Watson, E, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Wheeler, H, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, B, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Woodhead, F, Woods, J, Wootton, D, Worsley, J, Wraith, D, Wright, L, Wright, C, Wright, S, Xie, C, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Yousuf, A, Zawia, A, Zhao, B, Zongo, O, Evans, Rachael A, McAuley, Hamish J C, Harrison, Ewen M, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Elneima, Omer, Docherty, Annemarie B, Lone, Nazir I, Leavy, Olivia C, Daines, Luke, Baillie, J Kenneth, Brown, Jeremy S, Chalder, Trudie, De Soyza, Anthony, Diar Bakerly, Nawar, Easom, Nicholas, Geddes, John R, Greening, Neil J, Hart, Nick, Heaney, Liam G, Heller, Simon, Howard, Luke, Hurst, John R, Jacob, Joseph, Jenkins, R Gisli, Jolley, Caroline, Kerr, Steven, Kon, Onn M, Lewis, Keir, Lord, Janet M, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Raman, Betty, Richardson, Matthew, Rowland, Matthew, Semple, Malcolm G, Shah, Ajay M, Singh, Sally J, Sheikh, Aziz, Thomas, David, Toshner, Mark, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Wain, Louise V, and Brightling, Christopher E
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- 2021
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68. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
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Boztug, Kaan, Brunner, Juergen, Demel, Ulrike F., Förster-Waldl, Elisabeth, Gasteiger, Lukas M., Göschl, Lisa, Kojić, Marina, Schroll, Andrea, Seidel, Markus G., Wintergerst, Uwe, Wisgrill, Lukas, Sharapova, Svetlana O., Goffard, Jean-Christophe, Kerre, Tessa, Meyts, Isabelle, Roosens, Fine, Smet, Julie, Haerynck, Filomeen, Eric, Zelimir Pavle, Milenova, Veneta, Gagro, Alenka, Richter, Darko, Chovancova, Zita, Hlavackova, Eva, Litzman, Jiri, Milota, Tomas, Sediva, Anna, Elaziz, Dalia Abd, Alkady, Radwa Salaheldin, El Sayed El Hawary, Rabab, Eldash, Alia S., Galal, Nermeen, Lotfy, Sohilla, Meshaal, Safa S., Reda, Shereen M., Sobh, Ali, Elmarsafy, Aisha, Seppänen, Mikko R.J., Brosselin, Pauline, Courteille, Virginie, De Vergnes, Nathalie, Kracker, Sven, Pergent, Martine, Randrianomenjanahary, Philippe, Ahrenstorf, Gerrit, Albert, Michael H., Ankermann, Tobias, Atschekzei, Faranaz, Baumann, Ulrich, Becker, Benjamin C., Behrends, Uta, Belohradsky, Bernd H., Biegner, Anika-Kerstin, Binder, Nadine, Bode, Sebastian F.N., Boesecke, Christoph, Boetticher, Benedikt, Borte, Michael, Borte, Stephan, Classen, Carl Friedrich, Dirks, Johannes, Dückers, Gregor, El-Helou, Sabine, Ernst, Diana, Fasshauer, Maria, Fecker, Gisela, Felgentreff, Kerstin, Foell, Dirk, Ghosh, Sujal, Girschick, Hermann J., Goldacker, Sigune, Graf, Norbert, Graf, Dagmar, Greil, Johann, Hanitsch, Leif Gunnar, Hauck, Fabian, Heeg, Maximilian, Heine, Sabine I., Henes, Joerg C., Hoenig, Manfred, Holzer, Ursula, Holzinger, Dirk, Horneff, Gerd, Hundsdoerfer, Patrick, Jablonka, Alexandra, Jakoby, Donate, Joean, Oana, Kaiser-Labusch, Petra, Klemann, Christian, Kobbe, Robin, Körholz, Julia, Kramm, Christof M., Krüger, Renate, Landwehr-Kenzel, Sybille, Lehmberg, Kai, Liese, Johannes G., Lippert, Conrad Ferdinand, Maccari, Maria Elena, Masjosthusmann, Katja, Meinhardt, Andrea, Metzler, Markus, Morbach, Henner, Müller, Ingo, Naumann-Bartsch, Nora, Neubert, Jennifer, Niehues, Tim, Peter, Hans-Hartmut, Rieber, Nikolaus, Ritterbusch, Henrike, Rockstroh, Jürgen Kurt, Roesler, Joachim, Schauer, Uwe, Scheible, Raphael, Schmalzing, Marc, Schmidt, Reinhold Ernst, Schneider, Dominik T., Schreiber, Stefan, Schuetz, Catharina, Schulz, Ansgar, Schulze-Koops, Hendrik, Schulze-Sturm, Ulf, Schuster, Volker, Schwaneck, Eva C., Schwarz, Klaus, Schwarze-Zander, Carolynne, Sirin, Mehtap, Skapenko, Alla, Sogkas, Georgios, Sparber-Sauer, Monika, Speckmann, Carsten, Steinmann, Sandra, Stiehler, Sophie, Tenbrock, Klaus, von Bernuth, Horst, Warnatz, Klaus, Wasmuth, Jan-Christian, Weiss, Michael, Witte, Torsten, Wittke, Kirsten, Wittkowski, Helmut, Zeuner, Rainald A., Farmaki, Evangelia, Hatzistilianou, Maria N., Kakkas, Ioannis, Kanariou, Maria G., Kapousouzi, Androniki, Liatsis, Emmanouil, Maggina, Paraskevi, Papadopoulou-Alataki, Efimia, Raptaki, Maria, Speletas, Matthaios, Tantou, Sofia, Goda, Vera, Kriván, Gergely, Marodi, Laszlo, Abolhassani, Hassan, Aghamohammadi, Asghar, Rezaei, Nima, Feighery, Conleth, Leahy, Timothy Ronan, Ryan, Paul, Batzir, Nurit Assia, Garty, Ben Zion, Tamary, Hannah, Aiuti, Alessandro, Amodio, Donato, Azzari, Chiara, Barzaghi, Federica, Baselli, Lucia A., Cancrini, Caterina, Carrabba, Maria, Cazzaniga, Marco, Cesaro, Simone, Chinello, Matteo, Danieli, Maria Giovanna, Dellepiane, Rosa Maria, Fabio, Giovanna, Gambineri, Eleonora, Lodi, Lorenzo, Lougaris, Vassilios, Marasco, Carolina, Martire, Baldassarre, Marzollo, Antonio, Milito, Cinzia, Moschese, Viviana, Pignata, Claudio, Plebani, Alessandro, Porta, Fulvio, Quinti, Isabella, Ricci, Silvia, Soresina, Annarosa, Tommasini, Alberto, Vacca, Angelo, Vanessa, Clementina, Blažienė, Audra, Sitkauskiene, Brigita, Gowin, Ewelina, Heropolitańska-Pliszka, Edyta, Pietrucha, Barbara, Szaflarska, Anna, Więsik-Szewczyk, Ewa, Wolska-Kuśnierz, Beata, Esteves, Isabel, Faria, Emilia, Marques, Laura Hora, Neves, João Farela, Silva, Susana L., Teixeira, Carla, Pereira da Silva, Sara, Capilna, Brindusa Ruxandra, Guseva, Marina N., Shcherbina, Anna, Bobcakova, Anna, Ciznar, Peter, Gabzdilova, Juliana, Jesenak, Milos, Kapustova, Lenka, Orosova, Jaroslava, Petrovicova, Otilia, Raffac, Stefan, Kopač, Peter, Allende, Luis M., Antolí, Arnau, Blanch, Gemma Rocamora, Carbone, Javier, Dieli-Crimi, Romina, Garcia-Prat, Marina, Gil-Herrera, Juana, Gonzalez-Granado, Luis Ignacio, Agulló, Pilar Llobet, Olbrich, Peter, Parra-Martínez, Alba, Paz-Artal, Estela, Pleguezuelo, Daniel E., Rodríguez, Nerea Salmón, Sánchez-Ramón, Silvia, Santos-Pérez, Juan Luis, Solanich, Xavier, Soler-Palacin, Pere, González-Amores, Miriam, Ekwall, Olov, Fasth, Anders, Bitzenhofer-Grüber, Michaela, Candotti, Fabio, Dimitriou, Florentia, Heininger, Ulrich, Holbro, Andreas, Jandus, Peter, Kolios, Antonios G.A., Marschall, Karin, Schmid, Jana Pachlopnik, Posfay-Barbe, Klara M., Prader, Seraina, Reichenbach, Janine, Steiner, Urs C., Trück, Johannes, Bredius, Robbert G., de Kruijf- Bazen, Suzanne, de Vries, Esther, Henriet, Stefanie S.V., Kuijpers, Taco W., Potjewijd, Judith, Rutgers, Abraham, Stol, Kim, van Aerde, Koen J., Van den Berg, J. Merlijn, van de Ven, Annick A.J.M., Montfrans, Jorisvan, Aydemir, Sezin, Baris, Safa, Dogu, Figen, Ikinciogullari, Aydan, Karakoc-Aydiner, Elif, Kilic, Sara S., Kiykim, Ayca, Kökçü Karadağ, Şefika İlknur, Kutukculer, Necil, Ocak, Suheyla, UNAL, Ekrem, Boyarchuk, Oksana, Hilfanova, Anna, Kostyuchenko, Larysa V., Alachkar, Hana, Arkwright, Peter D., Baxendale, Helen E., Bernatoniene, Jolanta, Coulter, Tanya I., Garcez, Tomaz, Goddard, Sarah, Gompels, Mark M., Grigoriadou, Sofia, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Ibberson, Lisa, Nademi, Zoreh, Noorani, Sadia, Parvin, Shahnaz, Steele, Cathal Laurence, Thomas, Moira, Waruiru, Catherine, Yong, Patrick F.K., Bourne, Helen, Thalhammer, Julian, Kindle, Gerhard, Nieters, Alexandra, Rusch, Stephan, Fischer, Alain, Grimbacher, Bodo, Edgar, David, Buckland, Matthew, Mahlaoui, Nizar, and Ehl, Stephan
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- 2021
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69. Epilepsy & gambling: Risk factors for problem gambling behaviors in people with epilepsy
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Heaney, Dominic and Baxendale, Sallie
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- 2021
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70. Are psychological distress, substance misuse, and sexual sensation seeking associated with autoerotic asphyxiation-related distress?
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Roche, Kailey, Moss, Sarah, Baxendale, Emily, and Stephens, Skye
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- 2020
71. Neutralizing Anti-interferon-γ Autoantibodies: an Ameliorating Factor in COVID-19 Infection?
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Kacar, Mark, Cortes-Acevedo, Paulina, Patel, Vinesh, Carter, Clive, Hughes, Pamela, McGann, Hugh P., Gkrania-Klotsas, Effrossyni, Baxendale, Helen E., Barcenas-Morales, Gabriela, Doffinger, Rainer, and Savic, Sinisa
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- 2021
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72. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study
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Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Roynon, A, Northfield, J, Winchester, S, Cieciwa, P, Pai, A, Bakker, P, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Osuji, N, Chitalia, N, Bailey, T, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Brake, S, Gunn, J, Selassi, A, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Lewis, T, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Aeron-Thomas, J, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Shah, A, Russell, J, Brennan, D, Dave, A, Chawla, A, Westwell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Horsley, A, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Flanagan, D, Dhasmana, D, Fowler, S, Cameron, E, Prentice, L, Sinclair, C, Bateman, V, McLelland-Brooks, K, Ho, A, Murphy, M, Cochrane, A, Gibson, A, Black, K, Tempeton, K, Donaldson, S, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Cross, A, Mirfenderesky, M, Joyce, S, Sinanovic, I, Howard, M, Cowling, P, Brazil, M, Hanna, E, Abdelrazik, A, Brand, S, Sheridan, EA, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Browne, D, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Warren, S, Brooking, D, Pai, S, Druyeh, R, Smith, E, Stone, S, Meisner, S, Delgado, D, Underhill, E, Keen, L, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Birch, S, DeSilva, T, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Painter, Sharen, Price, C, Pepperell, J, James, K, Trinick, T, Moore, L, Day, J, Boulos, A, Knox, I, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Bain, SC, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, White, N, Longfellow, R, Hughes, LE, Green, ME, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Hilton, D, Powell, J, Jackson, A, Plant, AJ, Ahmed, N, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, RE, Donaghy, T, O'Kane, M, Shipman, K, Sierra, R, Parmar, C, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Saei, Ayoub, Andrews, Nick, Oguti, Blanche, Charlett, Andre, Wellington, Edgar, Stowe, Julia, Gillson, Natalie, Atti, Ana, Islam, Jasmin, Karagiannis, Ioannis, Munro, Katie, Khawam, Jameel, Chand, Meera A, Brown, Colin S, Ramsay, Mary, Lopez-Bernal, Jamie, and Hopkins, Susan
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- 2021
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73. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
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Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Winchester, S, Cieciwa, P, Pai, A, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Botes, D, Chitalia, N, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Callens, C, Beazer, S, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Gantert, K, Russell, J, Brennan, D, Dave, A, Chawla, A, Westell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Ingram, S, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Reeks, C, Fowler, S, Prentice, L, Spears, M, McKerron, G, McLelland-Brooks, K, Anderson, J, Donaldson, S, Templeton, K, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Mirfenderesky, M, Cross, A, Price, J, Joyce, S, Sinanovic, I, Howard, M, Lewis, T, Cowling, P, Potoczna, D, Brand, S, Sheridan, L, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Penny-Thomas, K, Pai, S, Zamikula, J, Smith, E, Stone, S, Boldock, E, Howcroft, D, Thompson, C, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Marsh, L, Tazzyman, S, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Jones, A, Price, C, Pepperell, J, Schultz, M, Day, J, Boulos, A, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, Staines, N, Longfellow, R, Green, ME, Hughes, LE, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Jory, H, Virgilio, E, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, R, Donaghy, T, Shipman, K, Sierra, R, Jones, N, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, De Silva, T, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Charlett, Andre, Atti, Ana, Monk, Edward J M, Simmons, Ruth, Wellington, Edgar, Cole, Michelle J, Saei, Ayoub, Oguti, Blanche, Munro, Katie, Wallace, Sarah, Kirwan, Peter D, Shrotri, Madhumita, Vusirikala, Amoolya, Rokadiya, Sakib, Kall, Meaghan, Zambon, Maria, Ramsay, Mary, Brooks, Tim, Brown, Colin S, Chand, Meera A, and Hopkins, Susan
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- 2021
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74. Neuropsychology of Insular Epilepsy
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Boucher, Olivier, primary, Baxendale, Sallie, additional, Bouthillier, Alain, additional, and Nguyen, Dang Khoa, additional
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- 2022
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75. Wendy Kopp
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Thomas, Matthew A. M., primary and Baxendale, Helen, additional
- Published
- 2022
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76. Machine-based production scheduling for rotomoulded plastics manufacturing.
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Mark Baxendale, James M. McGree, Aaron Bellette, and Paul Corry
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- 2021
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77. ALMOST-SURE STABILITY OF THE SINGLE MODE SOLUTION OF A NOISY NONLINEAR AUTOPARAMETRIC SYSTEM.
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BAXENDALE, PETER H. and NAMACHCHIVAYA, N. SRI
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LYAPUNOV exponents ,ENERGY transfer ,PENDULUMS ,NONLINEAR systems ,RESONANCE - Abstract
For a pendulum suspended below a vibrating block with white noise forcing, the solution in which the pendulum remains vertical is called the single mode solution. When this solution becomes unstable there is energy transfer from the block to the pendulum, helping to absorb the vibrations of the block. We study the Lyapunov exponent λ governing the almost-sure stability of the process linearized along the single mode solution. The linearized equation is excited by a combination of white and colored noise processes, which makes the evaluation of λ nontrivial. Depending on the relative sizes of the noise intensity and the damping coefficients, λ may take either negative or positive values. For white noise forcing of intensity εν we prove λ(ε) =λ
0 +ε²λ2 +O(ε4 ) as ε →0, where λ0 and λ2 are given explicitly in terms of the parameters of the system. [ABSTRACT FROM AUTHOR]- Published
- 2024
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78. Addressing neuropsychological diagnostics in adults with epilepsy: Introducing the International Classification of Cognitive Disorders in Epilepsy: The IC CODE Initiative
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Marc Norman, Sarah J. Wilson, Sallie Baxendale, William Barr, Cady Block, Robyn M. Busch, Alberto Fernandez, Erik Hessen, David W. Loring, Carrie R. McDonald, and Bruce P. Hermann
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cognitive diagnosis ,IC‐Code ,neuropsychology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract This paper addresses the absence of an international diagnostic taxonomy for cognitive disorders in patients with epilepsy. Initiated through the 2020 Memorandum of Understanding between the International League Against Epilepsy and the International Neuropsychological Society, neuropsychological representatives from both organizations met to address the problem and consequences of the absence of an international diagnostic taxonomy for cognitive disorders in epilepsy, overview potential solutions, and propose specific solutions going forward. The group concluded that a classification of cognitive disorders in epilepsy, including an overall taxonomy and associated operational criteria, was clearly lacking and sorely needed. This paper reviews the advantages and shortcomings of four existing cognitive diagnostic approaches, including taxonomies derived from the US National Neuropsychology Network, DSM‐V Neurocognitive Disorders, the Mild Cognitive Impairment classification from the aging/preclinical dementia literature, and the Research Domain Criteria Initiative. We propose a framework to develop a consensus‐based classification system for cognitive disorders in epilepsy that will be international in scope and be applicable for clinical practice and research globally and introduce the International Classification of Cognitive Disorders in Epilepsy (IC‐CODE) project.
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- 2021
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79. Benzo[1,2,3]dithiazole Compounds: A History of Synthesis and Their Renewed Applicability in Materials and Synthetic Chemistry, Originating from the Herz Reaction
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Alexander J. Nicholls and Ian R. Baxendale
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thiazole ,disulfur dichloride ,Herz reaction ,heterocycle formation ,organic radical anion ,semiconductor ,Chemistry ,QD1-999 - Abstract
The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although, with the benefit of increased diagnostic techniques and improved understanding, these structures are attracting greater attention in additional research settings, including applications as organic radicals and semiconductors. In addition, the benzodithiazole functionality has been shown to be a valuable synthetic intermediate in the preparation of a variety of other privileged aromatic and heteroaromatic targets, many of which are important APIs. In this review, the authors aim to critically analyse the potential applicability of these compounds to the fields of not only small-scale laboratory synthetic and medicinal chemistry but also commercial-scale processes and increasingly materials chemistry.
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- 2021
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80. A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries
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Guido Gambacorta, James S. Sharley, and Ian R. Baxendale
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flavours and fragrances ,flow chemistry ,process chemistry ,synthesis ,Science ,Organic chemistry ,QD241-441 - Abstract
Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a multibillion dollar industry and the flourishing sub-field of flow chemistry evolving within the discipline of organic synthesis. This is illustrated through selected examples of industrially important transformations specific to the fragrances and flavours industry and by highlighting the advantages of conducting these transformations by using a flow approach. This review is designed to be a compendium of techniques and apparatus already published in the chemical and engineering literature which would constitute a known solution or inspiration for commonly encountered procedures in the manufacture of fragrance and flavour chemicals.
- Published
- 2021
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81. Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear
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Ana A. Jones, Elvira Diamantopoulou, Sarah Baxendale, and Tanya T. Whitfield
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extracellular matrix ,heparan sulphate proteoglycan ,chondroitin sulphate proteoglycan ,epithelial morphogenesis ,semicircular canals ,otoliths ,Biology (General) ,QH301-705.5 - Abstract
Epithelial morphogenesis to form the semicircular canal ducts of the zebrafish inner ear depends on the production of the large glycosaminoglycan hyaluronan, which is thought to contribute to the driving force that pushes projections of epithelium into the lumen of the otic vesicle. Proteoglycans are also implicated in otic morphogenesis: several of the genes coding for proteoglycan core proteins, together with enzymes that synthesise and modify their polysaccharide chains, are expressed in the developing zebrafish inner ear. In this study, we demonstrate the highly specific localisation of chondroitin sulphate to the sites of epithelial projection outgrowth in the ear, present before any morphological deformation of the epithelium. Staining for chondroitin sulphate is also present in the otolithic membrane, whereas the otoliths are strongly positive for keratan sulphate. We show that heparan sulphate biosynthesis is critical for normal epithelial projection outgrowth, otolith growth and tethering. In the ext2 mutant ear, which has reduced heparan sulphate levels, but continues to produce hyaluronan, epithelial projections are rudimentary, and do not grow sufficiently to meet and fuse to form the pillars of tissue that normally span the otic lumen. Staining for chondroitin sulphate and expression of versican b, a chondroitin sulphate proteoglycan core protein gene, persist abnormally at high levels in the unfused projections of the ext2 mutant ear. We propose a model for wild-type epithelial projection outgrowth in which hyaluronan and proteoglycans are linked to form a hydrated gel that fills the projection core, with both classes of molecule playing essential roles in zebrafish semicircular canal morphogenesis.
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- 2022
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82. The importance of taking ART appropriately in children and adolescents with HIV-1 to reach the highest capacity of immune function later in life
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Katrine Schou Sandgaard, Triantafylia Gkouleli, Teresa Attenborough, Stuart Adams, Deena Gibbons, Mette Holm, Sarah Eisen, Helen Baxendale, Anita De Rossi, Savita Pahwa, Benny Chain, Athina S. Gkazi, and Nigel Klein
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HIV-1 ,children ,immune reconstitution ,thymic output ,antiretroviral therapy (ART) ,T cell receptor repertoires ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Current antiretroviral therapy (ART) guidelines recommend treating all children with HIV-1 infection. This has changed from the broader use of ART to treat children to improve morbidity and minimise mortality. However, prior to current recommendations, not everyone with HIV-1 received timely treatment. What happens to the paediatric immune system when HIV-1 replication is not appropriately supressed remains unclear. 11 samples from adolescents with HIV-1 on ART and uninfected controls in the UK, aged 12–25 years, were examined; overall, adolescents with CD4+ counts > 500/μl and a viral load < 50 copies/ml were compared with adolescents with CD4+ counts < 500/μl and a viral load > 50 copies/ml at time of sampling. Measurements of thymic output were combined with high throughput next generation sequencing and bioinformatics to systematically organize CD4+ and CD8+ T cell receptor (TCR) repertoires. TCR repertoire diversity, clonal expansions, TCR sequence sharing, and formation of TCR clusters in HIV-1 infected adolescents with successful HIV-1 suppression were compared to adolescents with ineffective HIV-1 suppression. Thymic output and CD4+ T cell numbers were decreased in HIV-1 infected adolescents with poor HIV-1 suppression. A strong homeostatic TCR response, driven by the decreased CD4+ T cell compartment and reduced thymic output was observed in the virally uncontrolled HIV-1-infected adolescents. Formation of abundant robust TCR clusters and structurally related TCRs were found in the adolescents with effective HIV-1 suppression. Numerous CD4+ T cell numbers in the virally controlled adolescents emphasize the importance of high thymic output and formation of robust TCR clusters in the maintenance of HIV-1 suppression. While the profound capacity for immune recovery in children may allow better opportunity to deal with immunological stress, when ART is taken appropriately, this study demonstrates new insights into the unique paediatric immune system and the immunological changes when HIV-1 replication is ongoing.
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- 2022
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83. Parental experiences of ultrarapid genomic testing for their critically unwell infants and children
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Brett, Gemma R., Martyn, Melissa, Lynch, Fiona, de Silva, Michelle G., Ayres, Samantha, Gallacher, Lyndon, Boggs, Kirsten, Baxendale, Anne, Schenscher, Sarah, King-Smith, Sarah, Fowles, Lindsay, Springer, Amanda, Lunke, Sebastian, Vasudevan, Anand, Krzesinski, Emma, Pinner, Jason, Sandaradura, Sarah A., Barnett, Christopher, Patel, Chirag, Wilson, Meredith, and Stark, Zornitza
- Published
- 2020
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84. Consent in forefoot surgery; What does it mean to the patient?
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Baxendale-Smith, Leo D., Middleton, Scott D., McKinley, John C., and Thomson, Colin E.
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- 2020
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85. The association of cognitive phenotypes with postoperative outcomes after epilepsy surgery in patients with temporal lobe epilepsy
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Baxendale, Sallie and Thompson, Pamela
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- 2020
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86. Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial
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Feig, Denice, Donat, Diane, Gandhi, Shital, Cleave, Barbara, Zhou, Vivian, Viguiliouk, Effie, Fong, Debbie, Strom, Michele, Deans, Melissa, Kamath, Aarthi, Godbout, Ariane, Weber, Florence, Mahone, Michele, Wo, Bi Lan, Bedard, Marie-Josee, Robinson, Melanie, Daigle, Sylvie, Leblanc, Sophie, Ludwig, Sora, Pockett, Sherri, Slater, Laurie, Donovan, Lois, Oldford, Carolyn, Young, Catherine, Virtanen, Heidi, Lodha, Abhay, Cooper, Stephanie, Yamamoto, Jennifer, Gougeon, Claire, Verhesen, Cheryl, Zahedi, Afshan, Taha, Nashwah, Turner, Marci, Neculau, Madalena, Robb, Cathy, Szwiega, Krystyna, Lee, Grace, Rey, Evelyne, Perreault, Sophie, Coolen, Jillian, Armson, Anthony B, Ransom, Thomas, Dias, Raquel, Slaunwhite, Janet, Baxendale, Darlene, Fanning, Cora, Halperin, Ilana, Gale, Veronica, Kader, Tina, Hirsimaki, Heidi, Long, Hélène, Lambert, Julie, Castonguay, Annie, Chalifoux, Steve, McManus, Ruth, Watson, Margaret, Powell, Anne-Marie, Sultana, Munira, ArthurHayward, Vinolia, Marin, Mauricio, Cauchi, Lorraine, MacBean, Leila, Keely, Erin, Malcolm, Janine, Clark, Heather, Karovitch, Allan, Belanger, Heather, Champagne, Josee, Schutt, Kayla, Sloan, Jennifer, Mitchell, Joyce, Favreau, Colette, O'Shea, Elaine, McGuire, Debbie, Peng, Melin, St Omer, Dynika, Lee, Julie, Klinke, Jennifer, Young, Sharon, Barts, Agnieszka, Carr, Francina, Subrt, Peter, Miller, David, Coles, Karen, Capes, Sarah, Smushkin, Galina, Phillips, Richard, Fergusson, Carol, Lacerte, Stacey, Houlden, Robyn, Breen, Adriana, Stone-Hope, Bonnie, Ryan, Edmond A, Kwong, Sarah, Rylance, Heather, Khurana, Rshmi, McNab, Tammy, Beauchamp, Shirley, Weisnagel, S John, D'Amours, Martin, Allen, Christyne, Dubé, Marie-Christine, Julien, Valérie-Ève, Lambert, Camille, Bourbonniere, Marie-Claude, Rheaume, Louise, Bouchard, Myriam, Carson, George, Williams, Suzanne, Wolfs, Maria, Berger, Howard, Cheng, Alice, Ray, Joel, Hanna, Amir, De Souza, Leanne, Berndl, Leslie, Meltzer, Sara, Garfield, Natasha, El-Messidi, Amira, Bastien, Louise, Segal, Shari, Thompson, David, Lim, Ken, Kong, Jason, Thompson, Sharon, Orr, Christine, Galway, Brenda, Parsons, Minnie, Rideout, Krista, Rowe, Bernadette, Crane, Joan, Andrews, Wayne, Joyce, Carol, Newstead-Angel, Jill, Brandt, Judy, Meier, Simona, Laurie, Josephine, McIntyre, David, Liley, Helen, Fox, Jane, Barrett, Helen, Maguire, Frances, Nerdal-Bussell, Marnie, Nie, Wenjun, Bergan, Carolyn, Cavallaro, Bekki, Tremellen, Anne, Cook, Anne, Simmons, David, Rajagopal, Rohit, Vizza, Lisa, Mattick, Maureen, Bishop, Claudia, Nema, Jodie, Kludas, Renee, McLean, Mark, Hendon, Susan, Sigmund, Allison, Wong, Vincent, Lata, Prem, Russell, Hamish, Singh, Razita, Zinman, Bernard, Asztalos, Elizabeth, Fantus, George I, Lipscombe, Lorraine L, Barrett, Jon, Tomlinson, George, Murphy, Kellie, McMurray, Keitha, Karanicolas, Paul, Murphy, Helen, Sanchez, Johanna, Klein, Gail, Tian, Simon, Tobin, Siobhan, Mangoff, Kathryn, Feig, Denice S, Donovan, Lois E, Sanchez, J Johanna, Fantus, I George, Hutton, Eileen, Barrett, Jon F R, Karanicolas, Paul J, McIntyre, H David, Tian, Simon Yu, and Murphy, Kellie E
- Published
- 2020
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87. Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations
- Author
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Adhya, Zoe, Alachkar, Hana, Anantharachagan, Ariharan, Antrobus, Richard, Arumugakani, Gururaj, Ashford, Sofie, Astle, William J., Attwood, Anthony, Bacchelli, Chiara, Batista, Joana, Baxendale, Helen E., Bethune, Claire, Bibi, Shahnaz, Bleda, Marta, Boardman, Barbara, Booth, Claire, Bradley, John R., Breen, Gerome, Brown, Matthew, Browning, Michael J., Brownlie, Mary, Buckland, Matthew S., Burns, Siobhan O., Burren, Oliver S., Carss, Keren, Chambers, John, Chandra, Anita, Brod, Naomi Clements, Clifford, Hayley, Cooper, Nichola, Daugherty, Louise C., Davies, E.G., Davies, Sophie, Davis, John, Deacock, Sarah, Deevi, Sri V.V., Dempster, John, Devlin, Lisa A., Dewhurst, Eleanor F., Downes, Kate, Drewe, Elizabeth, Duarte, Daniel, Edgar, J. David M., Edwards, Karen, Egner, William, El-Shanawany, Tariq, Erwood, Marie, Fletcher, Debra, Fox, James, Frary, Amy J., Frontini, Mattia, Furnell, Abigail, Gaspar, H. Bobby, Ghurye, Rohit, Gilmour, Kimberly C., Gleadall, Nicholas S., Goddard, Sarah, Gordins, Pavels, Gräf, Stefan, Grassi, Luigi, Greene, Daniel, Grigoriadou, Sofia, Hackett, Scott, Hague, Rosie, Haimel, Matthias, Harper, Lorraine, Hayman, Grant, Herwadkar, Archana, Hu, Fengyuan, Hughes, Stephen, Huissoon, Aarnoud P., James, Roger, Jolles, Stephen, Jolley, Jennifer, Jones, Julie, Karim, Yousuf, Kasanicki, Mary A., Kelleher, Peter, Kempster, Carly, Kiani, Sorena, Kingston, Nathalie, Klein, Nigel, Kostadima, Myrto, Kreuzhuber, Roman, Kuijpers, Taco W., Kumararatne, Dinakantha, Laffan, James, Allen, Hana Lango, Lear, Sara E., Linger, Rachel, Longhurst, Hilary, Lorenzo, Lorena E., Lyons, Paul A., Maimaris, Jesmeen, Manson, Ania, Mapeta, Rutendo, Martin, Jennifer, McCarthy, Mark I., McDermott, Elizabeth M., McKinney, Harriet, Meacham, Stuart, Megy, Karyn, Millar, Hazel, Mistry, Anoop, Morrisson, Valerie, Murng, Sai H.K., Nasir, Iman, Nejentsev, Sergey, Noorani, Sadia, Oksenhendler, Eric, Ouwehand, Willem H., Papadia, Sofia, Penkett, Christopher J., Petersen, Romina, Ponsford, Mark J., Qasim, Waseem, Quinn, Ellen, Quinti, Isabella, Raymond, F. Lucy, Rayner-Matthews, Paula J., Richter, Alex, Samani, Nilesh, Samarghitean, Crina, Sanchis-Juan, Alba, Sargur, Ravishankar B., Savic, Sinisa, Seneviratne, Suranjith L., Sewell, W.A. Carrock, Seyres, Denis, Shackley, Fiona, Shamardina, Olga, Simeoni, Ilenia, Simpson, Michael A., Smith, Kenneth G.C., Staines, Simon, Staples, Emily, Stark, Hannah, Stauss, Hans, Steele, Cathal L., Stephens, Jonathan, Stirrups, Kathleen E., Thaventhiran, James E., Thomas, David, Thomas, Moira J., Thomas, Patrick, Thrasher, Adrian J., Tilly, Tobias, Titterton, Catherine, Treadaway, Paul, Tuna, Salih, Turro, Ernest, Urniaz, Rafal, von Ziegenweidt, Julie, Walker, Neil, Watt, Christopher, Welch, Steven B., Whitehorn, Deborah, Willcocks, Lisa, Wood, Nicholas, Wood, Yvette, Workman, Sarita, Worth, Austen, Yates, Katherine, Yeatman, Nigel, Yong, Patrick F.K., Young, Timothy, Yu, Ping, Zlamalova, Eliska, Lorenzini, Tiziana, Fliegauf, Manfred, Klammer, Nils, Frede, Natalie, Proietti, Michele, Bulashevska, Alla, Camacho-Ordonez, Nadezhda, Varjosalo, Markku, Kinnunen, Matias, de Vries, Esther, van der Meer, Jos W.M., Ameratunga, Rohan, Roifman, Chaim M., Schejter, Yael D., Kobbe, Robin, Hautala, Timo, Atschekzei, Faranaz, Schmidt, Reinhold E., Schröder, Claudia, Stepensky, Polina, Shadur, Bella, Pedroza, Luis A., van der Flier, Michiel, Martínez-Gallo, Mónica, Gonzalez-Granado, Luis Ignacio, Allende, Luis M., Shcherbina, Anna, Kuzmenko, Natalia, Zakharova, Victoria, Neves, João Farela, Svec, Peter, Fischer, Ute, Ip, Winnie, Bartsch, Oliver, Barış, Safa, Klein, Christoph, Geha, Raif, Chou, Janet, Alosaimi, Mohammed, Weintraub, Lauren, Boztug, Kaan, Hirschmugl, Tatjana, Dos Santos Vilela, Maria Marluce, Holzinger, Dirk, Seidl, Maximilian, Lougaris, Vassilios, Plebani, Alessandro, Alsina, Laia, Piquer-Gibert, Monica, Deyà-Martínez, Angela, Slade, Charlotte A., Aghamohammadi, Asghar, Abolhassani, Hassan, Hammarström, Lennart, Kuismin, Outi, Helminen, Merja, Freeman, Alexandra F., Cook, Matthew, Bakhtiar, Shahrzad, Christiansen, Mette, Cunningham-Rundles, Charlotte, Patel, Niraj C., Rae, William, Niehues, Tim, Brauer, Nina, Syrjänen, Jaana, Seppänen, Mikko R.J., Tuijnenburg, Paul, Warnatz, Klaus, and Grimbacher, Bodo
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- 2020
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88. Cognitive rehabilitation and prehabilitation in people with epilepsy
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Baxendale, Sallie
- Published
- 2020
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89. Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration
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Arno, Gavin, Carss, Keren J, Hull, Sarah, Zihni, Ceniz, Robson, Anthony G, Fiorentino, Alessia, Hardcastle, Alison J, Holder, Graham E, Cheetham, Michael E, Plagnol, Vincent, Moore, Anthony, Raymond, F Lucy, Matter, Karl, Balda, Maria S, Webster, Andrew R, Black, Graeme, Hall, Georgina, Ingram, Stuart, Gillespie, Rachel, Manson, Forbes, Sergouniotis, Panagiotis, Inglehearn, Chris, Toomes, Carmel, Ali, Manir, McKibbin, Martin, Poulter, James, Khan, Kamron, Lord, Emma, Nemeth, Andrea, Downes, Susan, Halford, Stephanie, Yu, Jing, Lise, Stefano, Ponitkos, Nikos, Michaelides, Michel, Webster, Andrew, van Heyningen, Veronica, Aitman, Timothy, Alachkar, Hana, Ali, Sonia, Allen, Louise, Allsup, David, Ambegaonkar, Gautum, Anderson, Julie, Antrobus, Richard, Armstrong, Ruth, Arumugakani, Gururaj, Ashford, Sofie, Astle, William, Attwood, Antony, Austin, Steve, Bacchelli, Chiara, Bakchoul, Tamam, Bariana, Tadbir K, Baxendale, Helen, Bennett, David, Bethune, Claire, Bibi, Shahnaz, Bitner-Glindzicz, Maria, Bleda, Marta, Boggard, Harm, Bolton-Maggs, Paula, Booth, Claire, Bradley, John R, Brady, Angie, Brown, Matthew, Browning, Michael, Bryson, Christine, Burns, Siobhan, Calleja, Paul, Canham, Natalie, Carmichael, Jenny, Carss, Keren, Caulfield, Mark, Chalmers, Elizabeth, Chandra, Anita, Chinnery, Patrick, Chitre, Manali, Church, Colin, Clement, Emma, Clements-Brod, Naomi, Clowes, Virginia, Coghlan, Gerry, Collins, Peter, Cooper, Nichola, Creaser-Myers, Amanda, DaCosta, Rosa, Daugherty, Louise, Davies, Sophie, Davis, John, De Vries, Minka, Deegan, Patrick, Deevi, Sri VV, and Deshpande, Charu
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Biological Sciences ,Bioinformatics and Computational Biology ,Biomedical and Clinical Sciences ,Genetics ,Ophthalmology and Optometry ,Human Genome ,Rare Diseases ,Neurosciences ,Eye Disease and Disorders of Vision ,Aetiology ,2.1 Biological and endogenous factors ,Eye ,Adult ,Alleles ,Amino Acid Sequence ,Cell Polarity ,Epithelial Cells ,Exome ,Eye Proteins ,Female ,Genetic Variation ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Membrane Proteins ,Middle Aged ,Mutation ,Missense ,Nerve Tissue Proteins ,Pedigree ,Phenotype ,Retina ,Retinal Degeneration ,Retinal Dystrophies ,Rho Guanine Nucleotide Exchange Factors ,rhoA GTP-Binding Protein ,UK Inherited Retinal Disease Consortium ,NIHR Bioresource - Rare Diseases Consortium ,ARHGEF18 ,apicobasal polarity ,inherited retinal dystrophy ,p114RhoGEF ,retinal degeneration ,retinitis pigmentosa ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Mutations in more than 250 genes are implicated in inherited retinal dystrophy; the encoded proteins are involved in a broad spectrum of pathways. The presence of unsolved families after highly parallel sequencing strategies suggests that further genes remain to be identified. Whole-exome and -genome sequencing studies employed here in large cohorts of affected individuals revealed biallelic mutations in ARHGEF18 in three such individuals. ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA, a small GTPase protein that is a key component of tight junctions and adherens junctions. This biological pathway is known to be important for retinal development and function, as mutation of CRB1, encoding another component, causes retinal dystrophy. The retinal structure in individuals with ARHGEF18 mutations resembled that seen in subjects with CRB1 mutations. Five mutations were found on six alleles in the three individuals: c.808A>G (p.Thr270Ala), c.1617+5G>A (p.Asp540Glyfs∗63), c.1996C>T (p.Arg666∗), c.2632G>T (p.Glu878∗), and c.2738_2761del (p.Arg913_Glu920del). Functional tests suggest that each disease genotype might retain some ARHGEF18 activity, such that the phenotype described here is not the consequence of nullizygosity. In particular, the p.Thr270Ala missense variant affects a highly conserved residue in the DBL homology domain, which is required for the interaction and activation of RHOA. Previously, knock-out of Arhgef18 in the medaka fish has been shown to cause larval lethality which is preceded by retinal defects that resemble those seen in zebrafish Crumbs complex knock-outs. The findings described here emphasize the peculiar sensitivity of the retina to perturbations of this pathway, which is highlighted as a target for potential therapeutic strategies.
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- 2017
90. Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease
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Carss, Keren J, Arno, Gavin, Erwood, Marie, Stephens, Jonathan, Sanchis-Juan, Alba, Hull, Sarah, Megy, Karyn, Grozeva, Detelina, Dewhurst, Eleanor, Malka, Samantha, Plagnol, Vincent, Penkett, Christopher, Stirrups, Kathleen, Rizzo, Roberta, Wright, Genevieve, Josifova, Dragana, Bitner-Glindzicz, Maria, Scott, Richard H, Clement, Emma, Allen, Louise, Armstrong, Ruth, Brady, Angela F, Carmichael, Jenny, Chitre, Manali, Henderson, Robert HH, Hurst, Jane, MacLaren, Robert E, Murphy, Elaine, Paterson, Joan, Rosser, Elisabeth, Thompson, Dorothy A, Wakeling, Emma, Ouwehand, Willem H, Michaelides, Michel, Moore, Anthony T, Consortium, NIHR-BioResource Rare Diseases, Aitman, Timothy, Alachkar, Hana, Ali, Sonia, Allsup, David, Ambegaonkar, Gautum, Anderson, Julie, Antrobus, Richard, Arumugakani, Gururaj, Ashford, Sofie, Astle, William, Attwood, Antony, Austin, Steve, Bacchelli, Chiara, Bakchoul, Tamam, Bariana, Tadbir K, Baxendale, Helen, Bennett, David, Bethune, Claire, Bibi, Shahnaz, Bleda, Marta, Boggard, Harm, Bolton-Maggs, Paula, Booth, Claire, Bradley, John R, Brady, Angie, Brown, Matthew, Browning, Michael, Bryson, Christine, Burns, Siobhan, Calleja, Paul, Canham, Natalie, Carss, Keren, Caulfield, Mark, Chalmers, Elizabeth, Chandra, Anita, Chinnery, Patrick, Church, Colin, Clements-Brod, Naomi, Clowes, Virginia, Coghlan, Gerry, Collins, Peter, Cooper, Nichola, Creaser-Myers, Amanda, DaCosta, Rosa, Daugherty, Louise, Davies, Sophie, Davis, John, De Vries, Minka, Deegan, Patrick, Deevi, Sri VV, Deshpande, Charu, Devlin, Lisa, Doffinger, Rainer, Dormand, Natalie, Drewe, Elizabeth, and Edgar, David
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Genetics ,Neurosciences ,Eye Disease and Disorders of Vision ,Human Genome ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Eye ,Good Health and Well Being ,Adaptor Proteins ,Signal Transducing ,Alleles ,Base Sequence ,Choroideremia ,DNA Mutational Analysis ,Ethnicity ,Exome ,Female ,Genes ,Recessive ,Genetic Variation ,Genome ,Human ,Humans ,Introns ,Male ,Mutation ,Rare Diseases ,Retinal Diseases ,NIHR-BioResource Rare Diseases Consortium ,copy-number variants ,rare sequence variant ,retinal dystrophy ,whole-genome sequence ,Biological Sciences ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who have had whole-genome sequencing (n = 605), whole-exome sequencing (n = 72), or both (n = 45) performed, as part of the NIHR-BioResource Rare Diseases research study. We identified pathogenic variants (single-nucleotide variants, indels, or structural variants) for 404/722 (56%) individuals. Whole-genome sequencing gives unprecedented power to detect three categories of pathogenic variants in particular: structural variants, variants in GC-rich regions, which have significantly improved coverage compared to whole-exome sequencing, and variants in non-coding regulatory regions. In addition to previously reported pathogenic regulatory variants, we have identified a previously unreported pathogenic intronic variant in CHM in two males with choroideremia. We have also identified 19 genes not previously known to be associated with inherited retinal disease, which harbor biallelic predicted protein-truncating variants in unsolved cases. Whole-genome sequencing is an increasingly important comprehensive method with which to investigate the genetic causes of inherited retinal disease.
- Published
- 2017
91. Mapping the continuum of research strategies
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Baxendale, Matthew
- Published
- 2019
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92. Evaluation of a manualised speech and language therapy programme for children with social communication disorder: the SCIP feasibility study
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Catherine Adams, Jacqueline Gaile, Hazel Roddam, Janet Baxendale, Laura Clitheroe, and Richard Emsley
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Pragmatics ,Social communication ,Intervention ,Trial ,Speech ,Language therapy ,Medicine (General) ,R5-920 - Abstract
Abstract Background Children with Social (Pragmatic) Communication Disorder (SPCD) have long-term needs in using and processing social language and have a high risk of later mental health difficulties. A manualised speech and language therapy programme, the Social Communication Intervention Programme (SCIP) provides therapy content for SPCD. A feasibility study is required to derive more precise estimates of key parameters for a future trial of SCIP. Aims To assess the feasibility of conducting a substantive randomized controlled trial of SCIP for children with SPCD. Methods A questionnaire was distributed to paediatric speech and language therapists in England. Survey questions addressed number of eligible children, routine intervention provision and trial recruitment factors. In the second phase, a single-arm intervention feasibility study was completed. Fifteen speech and language practitioners identified 24 children aged 5–11 years with SPCD. Practitioners received training/supervision to deliver 20 SCIP therapy sessions to each child. At time 1, parents of participating children provided three communication goals; expected steps in each goal were defined. After intervention, parents and practitioners independently rated each goal compared to baseline ability. Two research practitioners compared parent post-intervention commentaries with outcome scores to derive guidance about clinical significance. All practitioners recorded audio commentaries on therapy experiences. Post-intervention interviews were conducted with 6 practitioners and 6 parents. An expert panel completed a Delphi consultation on trial design. Results Routine practice for SPCD varies widely. Children tend to be embedded in autism provision. Participation in a future trial was well supported provided resources are available to services. Outcomes analysis indicated all children except one made some progress on parent ratings; all children made progress on practitioner ratings. A power analysis for a future trial was carried out using current outcome measure as putative primary endpoint. Practitioners’ audio-diaries provided suggestions for training and adaption in a future trial. Outcomes and therapy methods were acceptable to practitioners and parents. Conclusions The feasibility study evaluated a novel outcome measure of social communication skills in SPCD. A power calculation indicated a feasible framework for a trial within a realistic period of time. Recommendations for recruitment methods, adaptation of manual and training were supported by practitioners and an expert panel. Trial registration Title: Speech-language therapy for child social communication disorder Trial ID: ISRCTN48030419 . Date registered: January 1, 2017. Registered retrospectively.
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- 2020
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93. Tracking on crystallization process of doped metal oxide IATO to optimize solvothermal conditions
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Hu, Te, Baxendale, Ian R., Su, Yuchang, Li, Fangjiang, Duan, Shaomi, Zhang, Yaping, and Fan, Honxin
- Published
- 2022
- Full Text
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94. Identification of potential biological targets of oxindole scaffolds via in silico repositioning strategies [version 2; peer review: 2 approved]
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Annachiara Tinivella, Luca Pinzi, Guido Gambacorta, Ian Baxendale, and Giulio Rastelli
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Brief Report ,Articles ,drug repurposing ,ligand-based ,molecular docking ,data mining ,synthetic products - Abstract
Background: Drug repurposing is an alternative strategy to traditional drug discovery that aims at predicting new uses for already existing drugs or clinical candidates. Drug repurposing has many advantages over traditional drug development, such as reduced attrition rates, time and costs. This is especially the case considering that most drugs investigated for repurposing have already been assessed for their safety in clinical trials. Repurposing campaigns can also be designed for libraries of already synthesized molecules at different levels of biological experimentation, from null to in vitro and in vivo. Such an extension of the “repurposing” concept is expected to provide significant advantages for the identification of novel drugs, as the synthetic accessibility of the desired compounds is often one of the limiting factors in the traditional drug discovery pipeline. Methods: In this work, we performed a computational repurposing campaign on a library of previously synthesized oxindole-based compounds, in order to identify potential new targets for this versatile scaffold. To this aim, ligand-based approaches were firstly applied to evaluate the similarity degree of the investigated compound library, with respect to ligands extracted from the DrugBank, Protein Data Bank (PDB) and ChEMBL databases. In particular, the 2D fingerprint-based and 3D shape-based similarity profiles were evaluated and compared for the oxindole derivates. Results: The analyses predicted a set of potential candidate targets for repurposing, some of them emerging by consensus of different computational analyses. One of the identified targets, i.e., the vascular endothelial growth factor receptor 2 (VEGFR-2) kinase, was further investigated by means of docking calculations, followed by biological testing of one candidate. Conclusions: While the compound did not show potent inhibitory activity towards VEGFR-2, the study highlighted several other possibilities of therapeutically relevant targets that may be worth of consideration for drug repurposing.
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- 2022
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95. Identification of potential biological targets of oxindole scaffolds via in silico repositioning strategies [version 1; peer review: 2 approved]
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Annachiara Tinivella, Luca Pinzi, Guido Gambacorta, Ian Baxendale, and Giulio Rastelli
- Subjects
Brief Report ,Articles ,drug repurposing ,ligand-based ,molecular docking ,data mining ,synthetic products - Abstract
Background: Drug repurposing is an alternative strategy to traditional drug discovery that aims at predicting new uses for already existing drugs or clinical candidates. Drug repurposing has many advantages over traditional drug development, such as reduced attrition rates, time and costs. This is especially the case considering that most drugs investigated for repurposing have already been assessed for their safety in clinical trials. Repurposing campaigns can also be designed for libraries of already synthesized molecules at different levels of biological experimentation, from null to in vitro and in vivo. Such an extension of the “repurposing” concept is expected to provide significant advantages for the identification of novel drugs, as the synthetic accessibility of the desired compounds is often one of the limiting factors in the traditional drug discovery pipeline. Methods: In this work, we performed a computational repurposing campaign on a library of previously synthesized oxindole-based compounds, in order to identify potential new targets for this versatile scaffold. To this aim, ligand-based approaches were firstly applied to evaluate the similarity degree of the investigated compound library, with respect to ligands extracted from the DrugBank, Protein Data Bank (PDB) and ChEMBL databases. In particular, the 2D fingerprint-based and 3D shape-based similarity profiles were evaluated and compared for the oxindole derivates. Results: The analyses predicted a set of potential candidate targets for repurposing, some of them emerging by consensus of different computational analyses. One of the identified targets, i.e., the vascular endothelial growth factor receptor 2 (VEGFR-2) kinase, was further investigated by means of docking calculations, followed by biological testing of one candidate. Conclusions: While the compound did not show potent inhibitory activity towards VEGFR-2, the study highlighted several other possibilities of therapeutically relevant targets that may be worth of consideration for drug repurposing.
- Published
- 2022
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96. Withdrawn Behavior in Preschool: Implications for Emotion Knowledge and Broader Emotional Competence
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Samantha E. Clark, Robin L. Locke, Sophia L. Baxendale, and Ronald Seifer
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preschoolers ,emotion ,development ,emotion knowledge ,context ,anger ,Psychology ,BF1-990 - Abstract
The present study investigated the respective roles of withdrawal, language, and context-inappropriate (CI) anger in the development of emotion knowledge (EK) among a subsample of 4 and 5 year-old preschoolers (n = 74). Measures included parent-reported withdrawn behavior, externalizing behavior, and CI anger, as well as child assessments of receptive language and EK. Ultimately, findings demonstrated that receptive language mediated the relationship between withdrawn behavior and situational EK. However, CI anger significantly interacted with receptive language, and, when incorporated into a second-stage moderated mediation analysis, moderate levels of CI anger rendered the indirect effect of withdrawn behavior on situational EK via receptive language insignificant. Cumulatively, these findings demonstrate a mechanism by which withdrawal may impact EK. They also indicate that such an effect may be attenuated in children with moderate levels of CI anger. Implications of these findings are discussed.
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- 2022
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97. Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19
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Youssif M. Ali, Nicholas J. Lynch, Priyanka Khatri, Ifeoluwa E. Bamigbola, Andrew C. Y. Chan, Munehisa Yabuki, Gregory A. Demopulos, Jonathan L. Heeney, Sumita Pai, Helen Baxendale, and Wilhelm J. Schwaeble
- Subjects
K. pneumoniae ,COVID-19 ,SARS-CoV-2 ,complement system ,bacterial infection ,S. aureus ,Immunologic diseases. Allergy ,RC581-607 - Abstract
A high incidence of secondary Klebsiella pneumoniae and Staphylococcus aureus infection were observed in patients with severe COVID-19. The cause of this predisposition to infection is unclear. Our data demonstrate consumption of complement in acute COVID-19 patients reflected by low levels of C3, C4, and loss of haemolytic activity. Given that the elimination of Gram-negative bacteria depends in part on complement-mediated lysis, we hypothesised that secondary hypocomplementaemia is rendering the antibody-dependent classical pathway activation inactive and compromises serum bactericidal activity (SBA). 217 patients with severe COVID-19 were studied. 142 patients suffered secondary bacterial infections. Klebsiella species were the most common Gram-negative organism, found in 58 patients, while S. aureus was the dominant Gram-positive organism found in 22 patients. Hypocomplementaemia was observed in patients with acute severe COVID-19 but not in convalescent survivors three months after discharge. Sera from patients with acute COVID-19 were unable to opsonise either K. pneumoniae or S. aureus and had impaired complement-mediated killing of Klebsiella. We conclude that hyperactivation of complement during acute COVID-19 leads to secondary hypocomplementaemia and predisposes to opportunistic infections.
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- 2022
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98. An examination of autoerotic asphyxiation in a community sample
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Baxendale, Emily, Roche, Kailey, and Stephens, Skye
- Published
- 2019
99. Quantum-tunneling controlled thermoelectricity in polymers
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Qiu, Manting and Baxendale, Mark
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- 2020
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100. Accurate ride comfort estimation combining accelerometer measurements, anthropometric data and neural networks
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Cieslak, M., Kanarachos, S., Blundell, M., Diels, C., Burnett, M., and Baxendale, A.
- Published
- 2020
- Full Text
- View/download PDF
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