51. Sequential kidney-liver transplantation from the same living donor for lecithin cholesterol acyl transferase deficiency.
- Author
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Ahmad SB, Miller M, Hanish S, Bartlett ST, Hutson W, Barth RN, and LaMattina JC
- Subjects
- Adult, Female, Humans, Kidney Failure, Chronic etiology, Lecithin Cholesterol Acyltransferase Deficiency complications, Male, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Lecithin Cholesterol Acyltransferase Deficiency surgery, Liver Transplantation methods, Living Donors
- Abstract
Background: Lecithin cholesterol acyl transferase (LCAT) deficiency is a rare autosomal recessive disorder of lipoprotein metabolism that results in end-stage renal disease (ESRD) necessitating transplantation. As LCAT is produced in the liver, combined kidney and liver transplantation was proposed to cure the clinical syndrome of LCAT deficiency., Methods: A 29-year-old male with ESRD secondary to LCAT deficiency underwent a sequential kidney-liver transplantation from the same living donor (LD). One year following the kidney transplant, auxiliary partial orthotopic liver transplant (APOLT) of a left lateral segment from the same donor was performed., Results: At 5 years follow-up, there have been no major complications, readmissions, or rejection episodes. Serum lipid abnormalities recurred within the first year, but liver and kidney allograft function remains intact., Conclusion: Few cases of sequential transplantation from the same LD have been performed in adults. This is the first APOLT and multi-organ transplant performed for LCAT deficiency. Sequential organ transplant from the same LD for ESRD secondary to a metabolic disorder of the liver is feasible in adults and should be further investigated., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
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