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51. The relationship of prenatal and infant antibiotic exposure with childhood overweight and obesity: A systematic review

Author

Baron, Ruth, Taye, Meron, Besseling-Van Der Vaart, Isolde, Ujčič-Voortman, Joanne, Szajewska, Hania, Seidell, Jacob C., Verhoeff, Arnoud, Baron, Ruth, Taye, Meron, Besseling-Van Der Vaart, Isolde, Ujčič-Voortman, Joanne, Szajewska, Hania, Seidell, Jacob C., and Verhoeff, Arnoud

Abstract

This study aimed to assess the evidence regarding the relationship between early-life antibiotic exposure and childhood overweight/obesity by reviewing observational studies on prenatal antibiotic exposure and systematic reviews on infant antibiotic exposure. A search in Pubmed, Embase and Google Scholar covering the period 1st January till 1st December 2018 led to the identification of five studies on prenatal antibiotic exposure and four systematic reviews on infant antibiotic exposure. Positive trends between prenatal antibiotic exposure and overweight/obesity were reported in all studies; two studies reported a significant overall relationship and the other three reported significant relationships under certain conditions. Effect sizes ranged from odds ratio (OR): 1.04 (0.62-1.74) to relative risk (RR): 1.77 (1.25-2.51). Regarding infant antibiotics, one review concluded there was substantial evidence that infant antibiotic exposure increased the risk of childhood overweight/obesity [pooled effect sizes: RR: 1.21 (1.09-1.33) for overweight and RR: 1.18 (1.12-1.25) for obesity]. Two reviews concluded there was some evidence for a relationship [pooled effect sizes: OR: 1.05 (1.00-1.11) and OR: 1.11 (1.02-1.20)]. The fourth review concluded the studies were too heterogeneous for meta-analyses and the evidence regarding the relationship between infant antibiotic exposure and childhood overweight/obesity was inconclusive. More well-designed studies are needed that include data on intra-partum antibiotics and address important potential confounders (including maternal and childhood infections). This review points to some evidence of a relationship between early-life antibiotic exposure and childhood overweight/obesity; this is especially evident in certain children (i.e. exposed to multiple and broad-spectrum antibiotics, earlier postnatal exposure and male gender) and merits further research.

Published
2020
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52. Young Adults With Anterior Ischemic Optic Neuropathy:A Multicenter Optic Disc Drusen Study

Author

Hamann, Steffen, Malmqvist, Lasse, Wegener, Marianne, Fard, Masoud Aghsaei, Biousse, Valérie, Bursztyn, Lulu, Citirak, Gülsenay, Costello, Fiona, Crum, Alison V., Digre, Kathleen, Fraser, J. Alexander, Huna-Baron, Ruth, Katz, Bradley, Lawlor, Mitchell, Newman, Nancy J., Peragallo, Jason H., Petzold, Axel, Sibony, Patrick A., Subramanian, Prem S., Warner, Judith E.A., Wong, Sui H., Fraser, Clare L., Hamann, Steffen, Malmqvist, Lasse, Wegener, Marianne, Fard, Masoud Aghsaei, Biousse, Valérie, Bursztyn, Lulu, Citirak, Gülsenay, Costello, Fiona, Crum, Alison V., Digre, Kathleen, Fraser, J. Alexander, Huna-Baron, Ruth, Katz, Bradley, Lawlor, Mitchell, Newman, Nancy J., Peragallo, Jason H., Petzold, Axel, Sibony, Patrick A., Subramanian, Prem S., Warner, Judith E.A., Wong, Sui H., and Fraser, Clare L.

Abstract

Purpose: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION. Design: Retrospective, cross-sectional multicenter study. Methods: All patients with NA-AION 50 years old or younger, seen in neuro-ophthalmology clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, and March 31, 2019, were identified. Patients were included if ODD were diagnosed by any method, or if ODD were excluded by enhanced-depth imaging optical coherence tomography (EDI-OCT) using ODDS Consortium guidelines. NA-AION eyes with ODD were termed “ODD-AION”; those without were termed “NODD-AION”. Results: A total of 65 patients (127 eyes) with NA-AION were included (mean 41 years old). Of the 74 eyes with NA-AION, 51% had ODD-AION, whereas 43% of fellow eyes without NA-AION had ODD (P =.36). No significant differences were found between ODD-AION and NODD-AION eyes in terms of Snellen best-corrected VA or perimetric mean deviation. According to EDI-OCT results, 28% of eyes with NODD-AION had peripapillary hyperreflective ovoid mass-like structures (PHOMS); 7% had hyperreflective lines, whereas 54% with ODD-AION had PHOMS; and 66% had hyperreflective lines (P =.006 and P <.001, respectively). Conclusions: Most of these young NA-AION patients had ODD. This indicates that ODD may be an independent risk factor for the development of NA-AION, at least in younger patients. This study suggests ODD-AION be recognized as a novel diagnosis.

Published
2020

53. Comment on:Morphologic Features of Buried Optic Disc Drusen on En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Author

Sibony, Patrick A., Biousse, Valérie, Bursztyn, Lulu, Costello, Fiona, Digre, Kathleen, Fraser, J. Alexander, Fraser, Clare L., Huna-Baron, Ruth, Katz, Bradley, Lawlor, Mitchell, Malmqvist, Lasse, Newman, Nancy J., Peragallo, Jason, Petzold, Axel, Subramanian, Prem S., Warner, Judith E.A., Wegener, Marianne, Wong, Sui, Hamann, Steffen, Sibony, Patrick A., Biousse, Valérie, Bursztyn, Lulu, Costello, Fiona, Digre, Kathleen, Fraser, J. Alexander, Fraser, Clare L., Huna-Baron, Ruth, Katz, Bradley, Lawlor, Mitchell, Malmqvist, Lasse, Newman, Nancy J., Peragallo, Jason, Petzold, Axel, Subramanian, Prem S., Warner, Judith E.A., Wegener, Marianne, Wong, Sui, and Hamann, Steffen

Published
2020

60. Comment on: Morphologic Features of Buried Optic Disc Drusen on En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Author

Sibony, Patrick A., primary, Biousse, Valérie, additional, Bursztyn, Lulu, additional, Costello, Fiona, additional, Digre, Kathleen, additional, Fraser, J. Alexander, additional, Fraser, Clare L., additional, Huna-Baron, Ruth, additional, Katz, Bradley, additional, Lawlor, Mitchell, additional, Malmqvist, Lasse, additional, Newman, Nancy J., additional, Peragallo, Jason, additional, Petzold, Axel, additional, Subramanian, Prem S., additional, Warner, Judith E.A., additional, Wegener, Marianne, additional, Wong, Sui, additional, and Hamann, Steffen, additional

Published
2020
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61. Young Adults With Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study

Author

Hamann, Steffen, primary, Malmqvist, Lasse, additional, Wegener, Marianne, additional, Fard, Masoud Aghsaei, additional, Biousse, Valérie, additional, Bursztyn, Lulu, additional, Citirak, Gülsenay, additional, Costello, Fiona, additional, Crum, Alison V., additional, Digre, Kathleen, additional, Fraser, J. Alexander, additional, Huna-Baron, Ruth, additional, Katz, Bradley, additional, Lawlor, Mitchell, additional, Newman, Nancy J., additional, Peragallo, Jason H., additional, Petzold, Axel, additional, Sibony, Patrick A., additional, Subramanian, Prem S., additional, Warner, Judith E.A., additional, Wong, Sui H., additional, and Fraser, Clare L., additional

Published
2020
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68. OCULAR SURFACE TEMPERATURE DIFFERENCES IN RETINAL VASCULAR DISEASES

Author

Naidorf-Rosenblatt, Hadar, Landau-Part, Daphna, Moisseiev, Joseph, Alhalel, Amir, Huna-Baron, Ruth, Skaat, Alon, Pilus, Sima, Levi, Lior, and Leshno, Ari

Abstract

The ocular surface temperature was measured, by thermographic imaging, among healthy subjects and patients with age-related macular degeneration or diabetic retinopathy. The ocular surface temperature was significantly higher among eyes with age-related macular degeneration and lower among eyes with diabetic retinopathy compared with controls.

Published
2022
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72. Blocked Crossings Crisis Draws Local and National Calls for Action.

Author

Sanders, Topher, Schwartz, Dan, and Baron, Ruth

Subjects
MUNICIPAL budgets, MODEL railroads, BUSINESS enterprises, SCHOOL board members
Abstract

A railroad administration spokesperson said the agency had been working on the April 27 safety advisory prior to ProPublica's April 3 story on long trains. Within 48 hours of an investigation about children having to crawl under parked trains to get to school in an Indiana suburb, residents packed a public meeting to demand solutions, the Federal Railroad Administration issued a safety advisory, a bipartisan group of Indiana lawmakers sent a letter to the U.S. Department of Transportation pleading for change and Norfolk Southern's CEO, Alan Shaw, got involved. On the same day last week, the railroad administration issued a safety advisory on blocked crossings, its second in a month coming in the immediate wake of ProPublica's investigative stories on the rails. [Extracted from the article]

Published
2023

74. Break a Dry Spell

Author

Baron, Ruth

Subjects
Sexual intercourse -- Planning, Sexual excitement -- Methods, Female-male relations -- Methods, Company business planning, Health
Abstract

In a world where being handcuffed or teased with a riding crop has become vanilla, a taboo that remains is this: not having sex at all. So whether you're coupled [...]

Published
2013

75. Prognostic value of JAK2V617F mutation in pseudotumor cerebri associated with cerebral venous sinus thrombosis.

Author

Zloto, Ofira, Lubetsky, Aharon, Ben‐Bassat Mizrachi, Iris, Kesler, Anat, Quiros, Peter A., and Huna‐Baron, Ruth

Subjects
SINUS thrombosis, INTRACRANIAL hypertension, CRANIAL sinuses, VENOUS thrombosis, NERVE fibers, PLATELET count
Abstract

Objectives: To examine the clinical characteristics and prognosis of cerebral venous sinus thrombosis (CVST) that presented as pseudotumor cerebri (PTC) patients with JAK2V617F mutation. Methods: Medical records of all consecutive patients that presented with PTC and a JAK2V617F mutation who were treated were retrospectively reviewed. Data regarding demographics and ocular presenting symptoms and signs, neurological signs, hematological factors treatment, and prognosis were collected. Results: The most common presenting symptoms were headache (5 patients, 83.3%) and visual obscurations (5 patients, 83.3%). CVST of the sagittal sinus and sigmoid sinus were the most common site of thrombus. Platelet count and hemoglobin count were higher than normal during follow‐up. There was significant change in the disk edema degree as well as decline in retinal nerve fiber layer (RNFL) thickness (P < 0.001, P < 0.001, Matched pairs). There was no significant change in visual acuity (VA) or mean deviation (MD) during follow‐up (P = 0.95, 0.64, respectively, Matched pairs). Conclusions: Pseudotumor cerebri resulting from CSVT in our patients with JAK2V617F mutation was frequent in young patients and needed medical and surgical treatment, without improvement in visual functions and in third caused poor visual outcome. Therefore, we believe that a screening test for JAK2V617F mutation should be considered for patients with CVST without known risk factor presenting with PTC, especially when sagittal sinus or sigmoid sinus involvement or thrombocytosis or high hemoglobin are found upon presentation. This might lead to more aggressive management which may improve the visual prognosis of those young patients. [ABSTRACT FROM AUTHOR]

Published
2019
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76. Brandon Sanderson

Author

Baron, Ruth

Subjects
A Memory of Light: The Gathering Storm (Novel), Authors -- Interviews, General interest
Abstract

Byline: Ruth Baron [ Q&A ] Brandon Sanderson If the epic-fantasy genre seems suited only to people who play Magic: The Gathering and own Star Wars bedding, consider this: Robert [...]

Published
2009

77. The DETAILS Power 40

Author

Baron, Ruth, Bhattacharji, Alex, Cerulo, Erica, Curran, Nick, Daly, Ian, Gordinier, Jeff, Hendrickson, Matt, Hintz, Katie, Kandell, Steve, Laukhuf, Adam, Noti, Yaran, Reed, Jebediah, Schaefer, Kayleen, and Walters, David

Subjects
Celebrities -- Evaluation, Age -- Influence, General interest
Abstract

When Barack Obama declared 'We are the change we've been waiting for,' the pundits scratched their heads. In retrospect, though, it seems as if That One was onto something. For [...]

Published
2008

78. Susac syndrome

Author

Vishnevskia-Dai, Vicktoria, primary, Chapman, Joav, additional, Sheinfeld, Roee, additional, Sharon, Tal, additional, Huna-Baron, Ruth, additional, Manor, Riri S., additional, Shoenfeld, Yehuda, additional, and Zloto, Ofira, additional

Published
2016
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82. Acute Optic Neuropathy and Development of Posttraumatic Stress Disorder.

Author

Fabian, Ido D., Abudi, Anat, Kinori, Michael, Moisseiev, Joseph, Liashets-Peer, Anna, Zohar, Joseph, and Huna-Baron, Ruth

Subjects
OPTIC nerve diseases, POST-traumatic stress disorder, NEUROPATHY, RETINAL detachment, MEDICAL screening, STEROID drugs, DIAGNOSIS, DIAGNOSIS of post-traumatic stress disorder, COMPARATIVE studies, OPHTHALMIC surgery, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, PSYCHOMETRICS, QUESTIONNAIRES, RESEARCH, EVALUATION research, DISEASE prevalence, SURGICAL decompression, SURGERY
Abstract

This study aimed to determine the prevalence and risk factors of posttraumatic stress disorder (PTSD) in 171 acute optic neuropathy (AON) patients, and to compare the findings to those previously reported on 366 rhegmatogenous retinal detachment (RRD) patients. PTSD positively screened AON patients underwent a structured psychiatric interview and a Visual Function Questionnaire (VFQ). Clinical measures were retrieved from medical records and compared between cohorts. None of the AON patients was diagnosed with PTSD, as opposed to 2.5% of RRD patients (P = 0.063). Of the AON cohort, 34% of patients were administered steroids, compared to none of the RRD patients, whereas all of the RRD patients underwent surgery, compared to none of the AON patients (P < 0.001). Clinical measures and VFQ scores were not found as risk factors for PTSD prediction. Results imply the potential role of surgery and of steroid treatment in developing PTSD in cases of ocular insults. [ABSTRACT FROM AUTHOR]

Published
2017
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100. Letter

Author

Salomon, Ophira, primary, Huna-Baron, Ruth, additional, Steinberg, David, additional, Kurtz, Shimon, additional, and Seligsohn, Uri, additional

Published
2000
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