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58. European Surveillance System on Contact Allergies (ESSCA): Contact allergies in relation to body sites in patients with allergic contact dermatitis

Author

Oosterhaven J, Uter W, Aberer W, Armario-Hita J, Ballmer-Weber B, Bauer A, Czarnecka-Operacz M, Elsner P, Garcia-Gavin J, Gimenez-Arnau A, John S, Krecisz B, Mahler V, Rustemeyer T, Sadowska-Przytocka A, Sanchez-Perez J, Simon D, Valiukeviciene S, Weisshaar E, Schuttelaar M, Beiteke U, Frosch P, Brasch J, Fuchs T, Balato A, Ayala F, Kiec-Swierczynska M, Fernandez-Redondo V, Mercader P, Ruiz I, Silvestre J, Bircher A, Grabbe J, and ESSCA Working Grp

Subjects
body site, contact allergy, allergic contact dermatitis, patch test, sensitization
Abstract

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on the prevalence of contact allergies to the European baseline series, both overall and in subgroups of patients. However, affected body sites have hitherto not been addressed. Objective: To determine the prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Methods: Analysis of data collected by the ESSCA (www.essca-dc.org) in consecutively patch tested patients, from 2009 to 2014, in eight European countries was performed. Cases were selected on the basis of the presence of minimally one positive patch test reaction to the baseline series, and a final diagnosis of ACD attributed to only one body site. Results: Six thousand two hundred and fifty-five cases were analysed. The head and hand were the most common single sites that ACD was attributed to. Differences between countries were seen for several body sites. Nickel, fragrance mix I, cobalt and methylchloroisothiazolinone/-methylisothiazolinone were the most frequent allergens reported for various body sites. Conclusions: Distinct allergen patterns per body site were observed. However, contact allergies were probably not always relevant for the dermatitis that patients presented with. The possibility of linking positive patch test reactions to relevance, along with affected body sites, should be a useful addition to patch test documentation systems.

Published
2019

59. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Author

Westerhout, J., Baumert, J.L., Blom, W.M., Allen, K.J., Ballmer-Weber, B., Crevel, R.W.R., Dubois, A.E.J., Fernández-Rivas, M., Greenhawt, M.J., Hourihane, J.O., Koplin, J.J., Kruizinga, A.G., Le, T.M., Sampson, H.A., Shreffler, W.G., Turner, P.J., Taylor, S.L., Houben, G.F., and Remington, B.C.

Subjects
No observed adverse effect level–lowest observed adverse effect level derivation, Double-blind, placebo-controlled food challengeeliciting dose, Risk management, Threshold, Food allergy, Food challenge, Decision-making process, Risk assessment
Abstract

Background: Food allergies are a significant public health issue, and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility of limiting risks to zero, quantitative allergen risk assessment and management strategies are needed. Objective: We sought to develop appropriate methods for informing population-based risk assessments and risk management programs to benefit all stakeholders but particularly patients with food allergy. Methods: Individual thresholds for food allergens (maximum tolerable doses and minimum eliciting doses) can ideally be established through double-blind, placebo-controlled food challenges. If double-blind, placebo-controlled food challenge data are not available, data from widely used open food challenges using predefined objective criteria can also provide useful data regarding minimum eliciting doses. For more than 20 years, the Netherlands Organisation for Applied Scientific Research and the Food Allergy Research and Resource Program at the University of Nebraska-Lincoln have been collecting individual maximum tolerable doses and minimum eliciting doses that produce objective symptoms from published and unpublished clinical data to better refine knowledge regarding the sensitivity of the population to food allergens. Results: In this article we provide in-depth insights into the methodology applied by the Netherlands Organisation for Applied Scientific Research and Food Allergy Research and Resource Program to derive individual maximum tolerable doses and minimum eliciting doses for objective symptoms from clinical food challenge data. More than 90 examples for determining individual allergic thresholds are presented. Conclusion: With the methodology presented in this article, we aim to stimulate harmonization and transparency in quantitative food allergen risk assessment and risk management programs, encouraging their wider adoption. © 2019 American Academy of Allergy, Asthma & Immunology

Published
2019

60. Erratum: Contact sensitization to plants of the Compositae family: Data of the Information Network of Departments of Dermatology (IVDK) from 2007 to 2016 (vol 80, pg 222, 2019)

Author

Baron, J. M., Grabbe, J., Ludwig, A., Bircher, A., Laubstein, B., Zuberbier, T., Worm, M., Simon, D., Effendy, Isaak, Dickel, H., Fartasch, M., Meyersburg, D., Patsinakidis, N., Zutt, M., Große-Hüttmann, P., Hausenblas, P., Martin, V., Reich, K., Breuer, K., Vieluf, D., Jung, A., Lippert, U., Pilz, B., Frosch, P. J., Mydlach, B., Pirker, C., Herbst, R., Kügler, K., Beiteke, U., Richter, G., Aschoff, R., Spornraft-Ragaller, P., Bauer, A., Koch, A., Peters, K. -P., Diepgen, T. L., Hertl, M., Mahler, V., Wagner, N., Ockenfels, H. -M., Hillen, U., Schwantes, H., Szliska, Ch., Geier, J., Meyer, J., Grunwald-Delitz, H., Kaatz, M., Kränke, B., Aberer, W., Jünger, M., Fuchs, Th., Buhl, T., Gaber, G., Lübbe, D., Kreft, B., Kiehn, M., Wessbecher, R., Coors, E., Witte, J., Seemann, U., Schröder-Kraft, C., Schaefer, T., Werfel, Th., Kapp, A., Schulze-Dirks, A., Hartmann, M., Jappe, U., Schäkel, K., Weisshaar, E., Löffler, H., Bahmer, F. A., Koch, P., Pföhler, C., Gebhardt, M., Wigger-Alberti, W., Schliemann, S., Brasch, J., Spring, P., Curdin, C., Treudler, R., Nestoris, St., Shimanovich, I., Hartmann, K., Recke, A., Becker, D., Bayerl, Ch., Kurzen, H., Booken, D., Klemke, C. -D., Ludwig-Peitsch, W., Schmieder, A., Pfützner, W., Hoffmann, J., Stadler, R., Oppel, T., Przybilla, B., Thomas, P., Schuh, T., Eben, R., Molin, S., Agathos, M., Ramrath, K., Georgi, M., Isbary, G., Rakoski, J., Darsow, U., Biedermann, T., Hellweg, B., Brehler, R., Behring, M., Müller, I., Debus, D., Bachtler, A., Ertner, K., Baur, V., Padeken, M., Kautz, O., Uter, W., John, S. M., Schwanitz, H. J., Schürer, N., Skudlik, Ch., Prager, W., Heise, H., Trcka, J., Rothaupt, D., Plaza, T., Nist, G., Rieker-Schwienbacher, J., Lischka, G., Roecken, M., Fischer, J., Staib, G., Hinrichs, R., Weiss, J., Arnold, J., Trautmann, A., Knopf, B., Teubner, D., Mechtel, D., Ballmer-Weber, B., and Navarini, A.

Published
2019

61. Wytyczne EAACI/GA2LEN/EDF/WAO dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki

Author

Zuberbier, T., primary, Aberer, W., additional, Asero, R., additional, Latiff, A., additional, Baker, D., additional, Ballmer-Weber, B., additional, Bernstein, J., additional, Bindslev-Jensen, C., additional, Brzoza, Z., additional, Bedrikow, R., additional, Canonica, G., additional, Church, M., additional, Craig, T., additional, Danilycheva, I., additional, Dressler, C., additional, Ensina, L., additional, Giménez-Arnau, A., additional, Godse, K., additional, Gonçalo, M., additional, Grattan, C., additional, Hebert, J., additional, Hide, M., additional, Kaplan, A., additional, Kapp, A., additional, Katelaris, C., additional, Kocatürk, E., additional, Kulthanan, K., additional, Larenas-Linnemann, D., additional, Leslie, T., additional, Magerl, M., additional, Mathelier-Fusade, P., additional, Meshkova, R., additional, Metz, M., additional, Nast, A., additional, Nettis, E., additional, Oude-Elberink, H., additional, Rosumeck, S., additional, Saini, S., additional, Sánchez-Borges, M., additional, Schmid-Grendelmeier, P., additional, Staubach, P., additional, Sussman, G., additional, Toubi, E., additional, Vena, G., additional, Vestergaard, C., additional, Wedi, B., additional, Werner, R., additional, Zhao, Z., additional, and Maurer, M., additional

Published
2020
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62. Nicht-Zöliakie-Gluten-/Weizen-Sensitivität (NCGS) – ein bislang nicht definiertes Krankheitsbild mit fehlenden Diagnosekriterien und unbekannter Häufigkeit

Author

Reese, I., primary, Schäfer, C., additional, Tebbe, J. Kleine-, additional, Ahrens, B., additional, Bachmann, O., additional, Ballmer-Weber, B., additional, Beyer, K., additional, Bischoff, S.C., additional, Blümchen, K., additional, Dölle, S., additional, Enck, P., additional, Enninger, A., additional, Huttegger, I., additional, Lämmel, S., additional, Lange, L., additional, Lepp, U., additional, Mahler, V., additional, Mönnikes, H., additional, Ockenga, J., additional, Otto, B., additional, Schnadt, S., additional, Szepfalusi, Z., additional, Treudler, R., additional, Wassmann-Otto, A., additional, Zuberbier, T., additional, Werfel, T., additional, and Worm, M., additional

Published
2019
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65. Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy

Author

Datema, M.R. van Ree, R. Asero, R. Barreales, L. Belohlavkova, S. de Blay, F. Clausen, M. Dubakiene, R. Fernández-Perez, C. Fritsche, P. Gislason, D. Hoffmann-Sommergruber, K. Jedrzejczak-Czechowicz, M. Jongejan, L. Knulst, A.C. Kowalski, M. Kralimarkova, T.Z. Le, T.-M. Lidholm, J. Papadopoulos, N.G. Popov, T.A. del Prado, N. Purohit, A. Reig, I. Seneviratne, S.L. Sinaniotis, A. Versteeg, S.A. Vieths, S. Zwinderman, A.H. Mills, E.N.C. Fernández-Rivas, M. Ballmer-Weber, B.

Abstract

Background: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity. Aim: To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to improve predictive accuracy. Methods: Patients reporting hazelnut allergy (n = 423) from 12 European cities were tested for IgE against individual hazelnut allergens. Symptoms (reported and during Double-blind placebo-controlled food challenge [DBPCFC]) were categorized in mild, moderate, and severe. Multiple regression models to predict severity were generated from clinical factors and sensitization patterns (CRD- and extract-based). Odds ratios (ORs) and areas under receiver-operating characteristic (ROC) curves (AUCs) were used to evaluate their predictive value. Results: Cor a 9 and 14 were positively (OR 10.5 and 10.1, respectively), and Cor a 1 negatively (OR 0.14) associated with severe symptoms during DBPCFC, with AUCs of 0.70-073. Combining Cor a 1 and 9 improved this to 0.76. A model using a combination of atopic dermatitis (risk), pollen allergy (protection), IgE against Cor a 14 (risk) and walnut (risk) increased the AUC to 0.91. At 92% sensitivity, the specificity was 76.3%, and the positive and negative predictive values 62.2% and 95.7%, respectively. For reported symptoms, associations and generated models proved to be almost identical but weaker. Conclusion: A model combining CRD with clinical background and extract-based serology is superior to CRD alone in assessing the risk of severe reactions to hazelnut, particular in ruling out severe reactions. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Published
2018

66. How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?

Author

Dubois, A. E. J., Turner, P. J., Hourihane, J., Ballmer‐Weber, B., Beyer, K., Chan, C.‐H., Gowland, M. H., O'Hagan, S., Regent, L., Remington, B., Schnadt, S., Stroheker, T., Crevel, R. W. R., University of Zurich, Dubois, A E J, and Medical Research Council (MRC)

Subjects
Precautionary allergen labelling (PAL), Allergy, Immunology, severity, 610 Medicine & health, Review Article, Cross Reactions, Severity of Illness Index, Severity, Risk Factors, eliciting dose, Humans, Immunology and Allergy, allergenic foods, Eliciting dose (ED), Review Articles, Risk assessment, 2403 Immunology, risk assessment, 10177 Dermatology Clinic, Allergens, Europe, Food, 1107 Immunology, precautionary allergen labelling, 2723 Immunology and Allergy, Immunization, Allergenic foods, Food Hypersensitivity
Abstract

Quantitative risk assessment for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depends on multiple factors, related to the allergen, the host and any treatments which might be administered. Some of these factors are plausibly still unknown. Quantitative risk assessment shows that limiting exposure through control of dose reduces the rates of reactions in allergic populations, but its impact on the relative frequency of severe reactions at different doses is unclear. Food challenge studies suggest that the relationship between dose of allergenic food and reaction severity is complex even under relatively controlled conditions. Because of these complexities, epidemiological studies provide very limited insight into this aspect of the dose-response relationship. Emerging data from single-dose challenges suggest that graded food challenges may overestimate the rate of severe reactions. It may be necessary to generate new data (such as those from single dose-challenges) to reliably identify the effect of dose on severity for use in quantitative risk assessment. Success will reduce uncertainty in the susceptible population and improve consumer choice.

Published
2018
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67. The urgent need for a harmonized severity scoring system for acute allergic reactions

Author

Muraro, A., primary, Fernandez-Rivas, M., additional, Beyer, K., additional, Cardona, V., additional, Clark, A., additional, Eller, E., additional, Hourihane, J. O'B., additional, Jutel, M., additional, Sheikh, A., additional, Agache, I., additional, Allen, K. J., additional, Angier, E., additional, Ballmer-Weber, B., additional, Bilò, M. B., additional, Bindslev-Jensen, C., additional, Camargo, C. A., additional, Cianferoni, A., additional, DunnGalvin, A., additional, Eigenmann, P. A., additional, Halken, S., additional, Hoffmann-Sommergruber, K., additional, Lau, S., additional, Nilsson, C., additional, Poulsen, L. K., additional, Rueff, F., additional, Spergel, J., additional, Sturm, G., additional, Timmermans, F., additional, Torres, M. J., additional, Turner, P., additional, van Ree, R., additional, Wickman, M., additional, Worm, M., additional, Mills, E. N. C., additional, and Roberts, G., additional

Published
2018
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69. Management of hypersensitivity reactions to iodinated contrast media

Author

Brockow, Knut, Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., Dewachter, P., Guéant, J. L., Rodriguez Guéant, R. M., Mouton Faivre, C., Ring, J., Romano, A., Sainte Laudy, J., Demoly, P., Pichler, W. J., Aberer, W., Ballmer Weber, B. K., Bilo, M. B., Birnbaum, J., Blanca, M., Blõmecke, B., Campi, P., De Weck, A., Drouet, M., Dzviga, C., Fernandez, J., Gomez, E., Kapp, A., Kidon, M., Kowalski, M., Laroche, D., Mertès, M., Merk, H., Moneret Vautrin, D. A., Pascual Marcos, C., Rebelo Gomes, E., Rueff, F., Sanz, M. L., Torres, M. J., Vervloet, D., Wedi, B., MARONE, GIANNI, Brockow, Knut, Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., Dewachter, P., Guéant, J. L., Rodriguez Guéant, R. M., Mouton Faivre, C., Ring, J., Romano, A., Sainte Laudy, J., Demoly, P., Pichler, W. J., Aberer, W., Ballmer Weber, B. K., Bilo, M. B., Birnbaum, J., Blanca, M., Blõmecke, B., Campi, P., De Weck, A., Drouet, M., Dzviga, C., Fernandez, J., Gomez, E., Kapp, A., Kidon, M., Kowalski, M., Laroche, D., Marone, Gianni, Mertès, M., Merk, H., Moneret Vautrin, D. A., Pascual Marcos, C., Rebelo Gomes, E., Rueff, F., Sanz, M. L., Torres, M. J., Vervloet, D., and Wedi, B.

Subjects
medicine.medical_specialty, Allergy, Premedication, Immunology, Drug Hypersensitivity, Iodinated contrast media, Skin test, Immediate reaction, Prevalence, Immunology and Allergy, Medicine, In patient, Iodine Compound, business.industry, Contrast media, Risk Factor, ALLERGIC/HYPERSENSITIVITY, Nonimmediate reaction, Diagnostic test, medicine.disease, Dermatology, Surgery, Skin reaction, business, Diagnosi, Human
Abstract

All iodinated contrast media (CM) are known to cause both immediate (≤1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future.

Published
2005
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70. The urgent need for a harmonized severity scoring system for acute allergic reactions

Author

Muraro, A, Fernandez-Rivas, M, Beyer, K, Cardona, V, Clark, A, Eller, E, Hourihane, JO, Jutel, M, Sheikh, A, Agache, I, Allen, KJ, Angier, E, Ballmer-Weber, B, Bilo, MB, Bindslev-Jensen, C, Camargo, CA, Cianferoni, A, DunnGalvin, A, Eigenmann, PA, Halken, S, Hoffmann-Sommergruber, K, Lau, S, Nilsson, C, Poulsen, LK, Rueff, F, Spergel, J, Sturm, G, Timmermans, F, Torres, MJ, Turner, P, van Ree, R, Wickman, M, Worm, M, Mills, ENC, Roberts, G, Muraro, A, Fernandez-Rivas, M, Beyer, K, Cardona, V, Clark, A, Eller, E, Hourihane, JO, Jutel, M, Sheikh, A, Agache, I, Allen, KJ, Angier, E, Ballmer-Weber, B, Bilo, MB, Bindslev-Jensen, C, Camargo, CA, Cianferoni, A, DunnGalvin, A, Eigenmann, PA, Halken, S, Hoffmann-Sommergruber, K, Lau, S, Nilsson, C, Poulsen, LK, Rueff, F, Spergel, J, Sturm, G, Timmermans, F, Torres, MJ, Turner, P, van Ree, R, Wickman, M, Worm, M, Mills, ENC, and Roberts, G

Abstract

The accurate assessment and communication of the severity of acute allergic reactions are important to patients, clinicians, researchers, the food industry, and public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach, and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore, there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that work across the range of allergenic triggers and address the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders' perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that are clinically meaningful and are useful for allergy healthcare professionals and researchers, and (ii) a three-grade-based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.

Published
2018

71. How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?

Author

Dubois, A E J; https://orcid.org/0000-0001-7909-0296, Turner, P J; https://orcid.org/0000-0001-9862-5161, Hourihane, J, Ballmer-Weber, B, Beyer, K, Chan, C -H, Gowland, M H, O'Hagan, S, Regent, L, Remington, B, Schnadt, S, Stroheker, T, Crevel, R W R, Dubois, A E J; https://orcid.org/0000-0001-7909-0296, Turner, P J; https://orcid.org/0000-0001-9862-5161, Hourihane, J, Ballmer-Weber, B, Beyer, K, Chan, C -H, Gowland, M H, O'Hagan, S, Regent, L, Remington, B, Schnadt, S, Stroheker, T, and Crevel, R W R

Abstract

Funding informationThis work was conducted by an expert group of the European branch of the International Life Sciences Institute, ILSI Europe. This publication was coordinated by the Food Allergy Task Force. Industry members of this task force are listed on the ILSI Europe website at http://ilsi.eu/task-forces/food-safety/food-allergy/. Experts are not paid for the time spent on this work; however, the nonindustry members within the expert group were offered support for travel and accommodation costs from the Food Allergy Task Force to attend meetings to discuss the manuscript and a small compensatory sum (honorarium) with the option to decline. The expert group carried out the work, that is collecting/analysing data/information and writing the scientific paper separate to other activities of the task force. The research reported is the result of a scientific evaluation in line with ILSI Europe's framework to provide a precompetitive setting for public‐private partnership. ILSI Europe facilitated scientific meetings and coordinated the overall project management and administrative tasks relating to the completion of this work. For further information about ILSI Europe, please email info@ilsieurope.be or call +3227710014. The opinions expressed herein and the conclusions of this publication are those of the authors and do not necessarily represent the views of ILSI Europe nor those of its member companies or any regulatory authority.

Published
2018

72. Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy

Author

Arts-assistenten Kinderen, MS Dermatologie/Allergologie, Infection & Immunity, Datema, M. R., van Ree, R., Asero, R., Barreales, L., Belohlavkova, S., de Blay, F., Clausen, M., Dubakiene, R., Fernández-Perez, C., Fritsche, P., Gislason, D., Hoffmann-Sommergruber, K., Jedrzejczak-Czechowicz, M., Jongejan, L., Knulst, A. C., Kowalski, M., Kralimarkova, T. Z., Le, T. M., Lidholm, J., Papadopoulos, N. G., Popov, T. A., del Prado, N., Purohit, A., Reig, I., Seneviratne, S. L., Sinaniotis, A., Versteeg, S. A., Vieths, S., Zwinderman, A. H., Mills, E. N.C., Fernández-Rivas, M., Ballmer-Weber, B., Arts-assistenten Kinderen, MS Dermatologie/Allergologie, Infection & Immunity, Datema, M. R., van Ree, R., Asero, R., Barreales, L., Belohlavkova, S., de Blay, F., Clausen, M., Dubakiene, R., Fernández-Perez, C., Fritsche, P., Gislason, D., Hoffmann-Sommergruber, K., Jedrzejczak-Czechowicz, M., Jongejan, L., Knulst, A. C., Kowalski, M., Kralimarkova, T. Z., Le, T. M., Lidholm, J., Papadopoulos, N. G., Popov, T. A., del Prado, N., Purohit, A., Reig, I., Seneviratne, S. L., Sinaniotis, A., Versteeg, S. A., Vieths, S., Zwinderman, A. H., Mills, E. N.C., Fernández-Rivas, M., and Ballmer-Weber, B.

Published
2018

73. Kutane Symptome nach Genuss pollenassoziierter Nahrungsmittel

Author

Ballmer-Weber, B. and Ballmer-Weber, B.

Abstract

Zusammenfassung: Die pollenassoziierte Nahrungsmittelallergie beruht auf einer Struktur- und Sequenzähnlichkeit allergener Proteine in Pollen und pflanzlichen Nahrungsmitteln. Die primäre IgE-Antwort richtet sich bei betroffenen Patienten in der Regel primär gegen Epitope auf Pollenproteinen mit sekundärer Erkennung homologer Epitope auf Nahrungsmittelallergenen. So leiden z.B. in Zentral- und Nordeuropa bis zu 80% der Birkenpollenallergiker gleichzeitig unter einer Nahrungsmittelallergie insbesondere gegen Stein- und Kernobst sowie gegen verschiedene Nüsse und Gemüse. Die Hauptmanifestation der pollenassoziierten Nahrungsmittelallergie ist das orale Allergiesyndrom, eine Kontakturtikaria der Mundschleimhaut. Neben der Kontakturtikaria insbesondere der Hände bei Berührung der allergenen Nahrungsmittel entwickeln Patienten mit pollenassoziierter Nahrungsmittelallergie bei deren Einnahme v.a. generalisierte Urtikaria und Angioödeme als kutane Symptome. Der Einfluss einer pollenassoziierten Nahrungsmittelallergie auf die Ausprägung und den Verlauf des atopischen Ekzems ist bis heute noch nicht definitiv geklärt

Published
2018

74. Patch test results with fragrance markers of the baseline series - Analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

Author

Frosch PJ, Duus Johansen J, Schuttelaar ML, Silvestre JF, Sánchez-Pérez J, Weisshaar E, Uter W, Aberer W, Bircher A, Simon D, Ballmer-Weber B, Spring P, Frosch P, Fuchs T, Brasch J, Bauer A, Elsner P, John SM, Mahler V, Johansen JD, Giménez Arnau A, García-Gavín J, Fernández-Redondo V, Amario-Hita JC, Mercader P, Ruiz I, Jolanki R, Pesonen M, Rantanen T, Ayala F, Balato A, Peserico A, Fortina AB, Filon FL, Corradin MT, Gallo R, Valiukeviciene S, Sliuziaviciene G, Coenraads PJ, Rustemeyer T, Kręcicz B, Kieć-Świerczyńska M, Spiewak R, Sadowska A, Czarnecka-Operacz M, Dugonik A, Pandurovic MK, Kmecl T, Vok M, Godnic S, Mesto N, Lunder T, Green CM, Wilkinson M, Sansom JE, King CM, Horne HL, English JS, Johnston GA, Statham BN, Chowdhury MM, Stone N, Cooper S, Gawkrodger DJ, Sabroe R, Holden C, Ormerod AD., Frosch, Pj, Duus Johansen, J, Schuttelaar, Ml, Silvestre, Jf, Sánchez-Pérez, J, Weisshaar, E, Uter, W, Aberer, W, Bircher, A, Simon, D, Ballmer-Weber, B, Spring, P, Frosch, P, Fuchs, T, Brasch, J, Bauer, A, Elsner, P, John, Sm, Mahler, V, Johansen, Jd, Giménez Arnau, A, García-Gavín, J, Fernández-Redondo, V, Amario-Hita, Jc, Mercader, P, Ruiz, I, Jolanki, R, Pesonen, M, Rantanen, T, Ayala, F, Balato, A, Peserico, A, Fortina, Ab, Filon, Fl, Corradin, Mt, Gallo, R, Valiukeviciene, S, Sliuziaviciene, G, Coenraads, Pj, Rustemeyer, T, Kręcicz, B, Kieć-Świerczyńska, M, Spiewak, R, Sadowska, A, Czarnecka-Operacz, M, Dugonik, A, Pandurovic, Mk, Kmecl, T, Vok, M, Godnic, S, Mesto, N, Lunder, T, Green, Cm, Wilkinson, M, Sansom, Je, King, Cm, Horne, Hl, English, J, Johnston, Ga, Statham, Bn, Chowdhury, Mm, Stone, N, Cooper, S, Gawkrodger, Dj, Sabroe, R, Holden, C, and Ormerod, Ad.

Subjects
Adult, Male, Allergic Contact, Patch Test, Petrolatum, Allergen, Dermatiti, regional difference, Perfume, Europe, contact sensitization, Retrospective Studie, Population Surveillance, Dermatitis, Allergic Contact, contact allergy, fragrance, Prevalence, Immunology and Allergy, Female, patch testing, Human
Published
2015

75. A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research

Author

Grabenhenrich, L.B. Reich, A. Bellach, J. Trendelenburg, V. Sprikkelman, A.B. Roberts, G. Grimshaw, K.E.C. Sigurdardottir, S. Kowalski, M.L. Papadopoulos, N.G. Quirce, S. Dubakiene, R. Niggemann, B. Fernández-Rivas, M. Ballmer-Weber, B. van Ree, R. Schnadt, S. Mills, E.N.C. Keil, T. Beyer, K.

Abstract

Background: The conduct of oral food challenges as the preferred diagnostic standard for food allergy (FA) was harmonized over the last years. However, documentation and interpretation of challenge results, particularly in research settings, are not sufficiently standardized to allow valid comparisons between studies. Our aim was to develop a diagnostic toolbox to capture and report clinical observations in double-blind placebo-controlled food challenges (DBPCFC). Methods: A group of experienced allergists, paediatricians, dieticians, epidemiologists and data managers developed generic case report forms and standard operating procedures for DBPCFCs and piloted them in three clinical centres. The follow-up of the EuroPrevall/iFAAM birth cohort and other iFAAM work packages applied these methods. Recommendations: A set of newly developed questionnaire or interview items capture the history of FA. Together with sensitization status, this forms the basis for the decision to perform a DBPCFC, following a standardized decision algorithm. A generic form including details about severity and timing captures signs and symptoms observed during or after the procedures. In contrast to the commonly used dichotomous outcome FA vs no FA, the allergy status is interpreted in multiple categories to reflect the complexity of clinical decision-making. Conclusion: The proposed toolbox sets a standard for improved documentation and harmonized interpretation of DBPCFCs. By a detailed documentation and common terminology for communicating outcomes, these tools hope to reduce the influence of subjective judgment of supervising physicians. All forms are publicly available for further evolution and free use in clinical and research settings. © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.

Published
2017

76. Allergy / Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot

Author

Zulehner, N., Nagl, B., Briza, P., Roulias, A., Ballmer-Weber, B., Zlabinger, G. J., Ferreira, F., and Bohle, B.

Subjects
Dau c 1, birch pollen-associated food allergy, Bet v 1, T cells, hemic and immune systems, allergic sensitization
Abstract

BACKGROUND: In contrast to other Bet v 1-related food allergens, the major carrot allergen, Dau c 1, has been suggested to induce food allergy independently from Bet v 1. As T cells are crucial in the sensitization process, we sought to characterize the T-cell response to Dau c 1 and its cross-reactivity with Bet v 1. METHODS: Dau c 1-specific T-cell lines (TCL) and clones (TCC) established from PBMC of birch pollen-allergic patients with carrot allergy were analyzed for reactivity to Bet v 1, epitope specificity, allergen-induced cytokine secretion, and expression of integrins 47 and 41, critical for gut and lung homing, respectively. mRNA expression of GATA3 and Tbet was analyzed in sorted CD3+ CD4+ CFSElow cells proliferating upon stimulation of PBMC with Dau c 1 or Bet v 1. Dau c 1 was incubated with endolysosomal proteases, and the resulting fragments were identified by mass spectrometry. RESULTS: Among 14 distinct T-cell-activating regions, Dau c 1139-153 was recognized by 55% of the patients. Only 6 of 15 (40%) Dau c 1-specific TCL and 9 of 21 (43%) TCC reacted with Bet v 1. Bet v 1-nonreactive TCC were mainly Th1-like and showed a higher expression of the integrin 7 and a significantly lower expression of the integrin 1 than Bet v 1-positive TCC. A Th1-like response was also detected in Dau c 1-reactive CD3+ CD4+ CFSElow cells. Full-length Dau c 1 was still detectable after 48 h of endolysosomal degradation. Proteolytic fragments of Dau c 1 matched its T-cell-activating regions. CONCLUSION: Dau c 1 displays several characteristics of sensitizing allergens, namely a major T-cell-activating region, low susceptibility to endolysosomal degradation, and induction of a Bet v 1-independent T-cell response. These cellular insights confirm that the major carrot allergen has a special status among Bet v 1-related food allergens. (VLID)2220291

Published
2017
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78. How does dose impact on the severity of food‐induced allergic reactions, and can this improve risk assessment for allergenic foods?

Author

Dubois, A. E. J., primary, Turner, P. J., additional, Hourihane, J., additional, Ballmer‐Weber, B., additional, Beyer, K., additional, Chan, C.‐H., additional, Gowland, M. H., additional, O'Hagan, S., additional, Regent, L., additional, Remington, B., additional, Schnadt, S., additional, Stroheker, T., additional, and Crevel, R. W. R., additional

Published
2018
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80. EAACI molecular allergology user's guide

Author

Matricardi, P.M., Kleine-Tebbe, J., Hoffmann, H.J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R.C., Agache, I., Asero, R., Ballmer-Weber, B., Barber, D., Beyer, K., Biedermann, T., Bilo, M.B., Blank, S., Bohle, B., Bosshard, P.P., Breiteneder, H., Brough, H.A., Caraballo, L.R., Caubet, J.C., Crameri, R., Davies, J.M., Douladiris, N., Ebisawa, M., EIgenmann, P.A., Fernandez-Rivas, M., Ferreira, F., Gadermaier, G., Glatz, M., Hamilton, R.G., Hawranek, T., Hellings, P.W., Hoffmann-Sommergruber, K., Jakob, T., Jappe, U., Jutel, M., Kamath, S.D., Knol, E.F., Korosec, P., Kuehn, A., Lack, G., Lopata, A.L., Makela, M.J., Morisset, M., Niederberger, V., Nowak-Węgrzyn, A.H., Papadopoulos, N.G., Pastorello, E.A., Pauli, G., Platts-Mills, T., Posa, D., Poulsen, L.K., Raulf, M., Sastre, J., Scala, E., Schmid, J.M., Schmid-Grendelmeier, P., van Hage, M., van Ree, R., Vieths, S., Weber, R., Wickman, M., Muraro, A., and Ollert, M.

Subjects
Ige, Ige Cross-reactivity, Allergy, Allergy Diagnosis, Anaphylaxis, Asthma, Atopic Dermatitis, Component-resolved Diagnosis, Diagnosis, Diagnostic Algorithms, Food Allergy, Guidelines, Lipocalins, Microarray, Molecular Allergology, Non-spec, food and beverages
Abstract

The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

Published
2016

82. EAACI Molecular Allergology User's Guide

Author

Matricardi, P.M. Kleine-Tebbe, J. Hoffmann, H.J. Valenta, R. Hilger, C. Hofmaier, S. Aalberse, R.C. Agache, I. Asero, R. Ballmer-Weber, B. Barber, D. Beyer, K. Biedermann, T. Bilò, M.B. Blank, S. Bohle, B. Bosshard, P.P. Breiteneder, H. Brough, H.A. Caraballo, L. Caubet, J.C. Crameri, R. Davies, J.M. Douladiris, N. Ebisawa, M. EIgenmann, P.A. Fernandez-Rivas, M. Ferreira, F. Gadermaier, G. Glatz, M. Hamilton, R.G. Hawranek, T. Hellings, P. Hoffmann-Sommergruber, K. Jakob, T. Jappe, U. Jutel, M. Kamath, S.D. Knol, E.F. Korosec, P. Kuehn, A. Lack, G. Lopata, A.L. Mäkelä, M. Morisset, M. Niederberger, V. Nowak-Węgrzyn, A.H. Papadopoulos, N.G. Pastorello, E.A. Pauli, G. Platts-Mills, T. Posa, D. Poulsen, L.K. Raulf, M. Sastre, J. Scala, E. Schmid, J.M. Schmid-Grendelmeier, P. van Hage, M. van Ree, R. Vieths, S. Weber, R. Wickman, M. Muraro, A. Ollert, M.

Subjects
food and beverages
Abstract

The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled ‘component-resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Published
2016

83. Component‐resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy

Author

Datema, M. R., primary, van Ree, R., additional, Asero, R., additional, Barreales, L., additional, Belohlavkova, S., additional, de Blay, F., additional, Clausen, M., additional, Dubakiene, R., additional, Fernández‐Perez, C., additional, Fritsche, P., additional, Gislason, D., additional, Hoffmann‐Sommergruber, K., additional, Jedrzejczak‐Czechowicz, M., additional, Jongejan, L., additional, Knulst, A. C., additional, Kowalski, M., additional, Kralimarkova, T. Z., additional, Le, T.‐M., additional, Lidholm, J., additional, Papadopoulos, N. G., additional, Popov, T. A., additional, del Prado, N., additional, Purohit, A., additional, Reig, I., additional, Seneviratne, S. L., additional, Sinaniotis, A., additional, Versteeg, S. A., additional, Vieths, S., additional, Zwinderman, A. H., additional, Mills, E. N. C., additional, Fernández‐Rivas, M., additional, and Ballmer‐Weber, B., additional

Published
2017
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85. Erratum : IgE recognition patterns in peanut allergy are age dependent: Perspectives of the EuroPrevall study (Allergy (2015) 70 (391-406))

Author

Ballmer-Weber, B. K., Lidholm, J., Fernández-Rivas, M., Seneviratne, S., Hanschmann, K. M., Vogel, L., Bures, P., Fritsche, P., Summers, C., Knulst, A. C., Le, T. M., Reig, I., Papadopoulos, N. G., Sinaniotis, A., Belohlavkova, S., Popov, T., Kralimarkova, T., De Blay, F., Purohit, A., Clausen, M., Kowalski, M. L., Asero, R., Dubakiene, R., Barreales, L., Clare Mills, E. N., Van Ree, R., and Vieths, S.

Subjects
Immunology, Immunology and Allergy
Published
2015

88. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Author

Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, 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LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, and Jones, C

Published
2017

89. European Surveillance System on Contact Allergies (ESSCA):results with the European baseline series, 2013/14

Author

Uter, W, Amario-Hita, J C, Balato, A, Ballmer-Weber, B, Bauer, A, Belloni Fortina, A, Bircher, A, Chowdhury, M M U, Cooper, S M, Czarnecka-Operacz, M, Dugonik, A, Gallo, R, Giménez-Arnau, A, Johansen, J D, John, S M, Kieć-Świerczyńska, M, Kmecl, T, Kręcisz, B, Larese Filon, F, Mahler, V, Pesonen, M, Rustemeyer, T, Sadowska-Przytocka, A, Sánchez-Pérez, J, Schliemann, S, Schuttelaar, M L, Simon, D, Spiewak, R, Valiukevičienė, S, Weisshaar, E, White, I R, Wilkinson, S M, Uter, W, Amario-Hita, J C, Balato, A, Ballmer-Weber, B, Bauer, A, Belloni Fortina, A, Bircher, A, Chowdhury, M M U, Cooper, S M, Czarnecka-Operacz, M, Dugonik, A, Gallo, R, Giménez-Arnau, A, Johansen, J D, John, S M, Kieć-Świerczyńska, M, Kmecl, T, Kręcisz, B, Larese Filon, F, Mahler, V, Pesonen, M, Rustemeyer, T, Sadowska-Przytocka, A, Sánchez-Pérez, J, Schliemann, S, Schuttelaar, M L, Simon, D, Spiewak, R, Valiukevičienė, S, Weisshaar, E, White, I R, and Wilkinson, S M

Abstract

BACKGROUND: Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, such as introduction of new substances, new products or formulations and regulatory intervention, the spectrum of contact sensitization changes.OBJECTIVE: To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe.METHODS: Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (ESSCA, www.essca-dc.org) in consecutively patch-tested patients, 2013/14, in 46 departments in 12 European countries.RESULTS: Altogether, 31 689 patients were included in the analysis. Compared to a similar analysis in 2004, the prevalence of contact allergy to methylisothiazolinone went up to around 20% in several departments. In comparison, contact allergy to the metals nickel, cobalt and chromium remained largely stable, at 18.1%, 5.9% and 3.2%, respectively, similar to mostly unchanged prevalence with fragrance mix I, II and Myroxylon pereirae (balsam of Peru) at 7.3%, 3.8% and 5.3%, respectively. In the subgroup of departments diagnosing (mainly) patients with occupational contact dermatitis, the prevalence of work-related contact allergies such as epoxy resin or rubber additives was found to be increased, compared to general dermatology departments.CONCLUSION: Continuous surveillance of contact allergy based on network data offers the identification of time trends or persisting problems, and thus enables focussing in-depth research (subgroup analyses, exposure analysis) on areas where it is needed.

Published
2017

90. A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research

Author

Grabenhenrich, L B, Reich, A, Bellach, J, Trendelenburg, V, Sprikkelman, A B, Roberts, G, Grimshaw, K E C; https://orcid.org/0000-0003-3649-7963, Sigurdardottir, S, Kowalski, M L, Papadopoulos, N G, Quirce, S, Dubakiene, R, Niggemann, B, Fernández-Rivas, M, Ballmer-Weber, B, van Ree, R, Schnadt, S, Mills, E N C, Keil, T, Beyer, K, Grabenhenrich, L B, Reich, A, Bellach, J, Trendelenburg, V, Sprikkelman, A B, Roberts, G, Grimshaw, K E C; https://orcid.org/0000-0003-3649-7963, Sigurdardottir, S, Kowalski, M L, Papadopoulos, N G, Quirce, S, Dubakiene, R, Niggemann, B, Fernández-Rivas, M, Ballmer-Weber, B, van Ree, R, Schnadt, S, Mills, E N C, Keil, T, and Beyer, K

Published
2017

91. Hände sind besonders empfindlich

Author

Ballmer-Weber, B K, University of Zurich, and Ballmer-Weber, B K

Subjects
10177 Dermatology Clinic, 610 Medicine & health
Published
2012

93. Nahrungsmittelallergien bei Erwachsenen

Author

Ballmer-Weber, B K, University of Zurich, Schmid-Grendelmeier, P, and Ballmer-Weber, B K

Subjects
10177 Dermatology Clinic, 610 Medicine & health
Published
2012

96. Allergic reactions to food proteins

Author

Ballmer-Weber, B K, University of Zurich, and Ballmer-Weber, B K

Subjects
Diabetes and Metabolism, 2712 Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Endocrinology, 10177 Dermatology Clinic, 2916 Nutrition and Dietetics, Medicine (miscellaneous), 610 Medicine & health, 2701 Medicine (miscellaneous), General Medicine
Published
2011
Full Text
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100. Allergien

Author

Ballmer-Weber, B K, University of Zurich, Buchmann, P, Degen, L, and Ballmer-Weber, B K

Subjects
10177 Dermatology Clinic, 610 Medicine & health
Published
2010

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