4,795 results on '"Baldari, A"'
Search Results
52. Modified distalization shoulder angle and lateralization shoulder angle show weakly correlation with clinical outcomes following reverse shoulder arthroplasty
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Saccone, Luca, Giovannetti de Sanctis, Edoardo, Caldaria, Antonio, Biagi, Nicolò, Baldari, Angelo, De Angelis D'Ossat, Gian Mauro, La Verde, Luca, Palumbo, Alessio, and Franceschi, Francesco
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- 2024
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53. Sleep quality and sex-related factors in adult patients with immune-mediated diabetes: a large cross-sectional study
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Bongiorno, Claudio, Moscatiello, Simona, Baldari, Michele, Saudelli, Enrico, Zucchini, Stefano, Maltoni, Giulio, Ribichini, Danilo, Bruco, Alessia, Lo Preiato, Valentina, Laffi, Gilberto, Pagotto, Uberto, and Di Dalmazi, Guido
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- 2023
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54. European Association for Endoscopic Surgery (EAES) consensus on Indocyanine Green (ICG) fluorescence-guided surgery
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Cassinotti, E., Al-Taher, M., Antoniou, S. A., Arezzo, A., Baldari, L., Boni, L., Bonino, M. A., Bouvy, N. D., Brodie, R., Carus, T., Chand, M., Diana, M., Eussen, M. M. M., Francis, N., Guida, A., Gontero, P., Haney, C. M., Jansen, M., Mintz, Y., Morales-Conde, S., Muller-Stich, B. P., Nakajima, K., Nickel, F., Oderda, M., Parise, P., Rosati, R., Schijven, M. P., Silecchia, G., Soares, A. S., Urakawa, S., and Vettoretto, N.
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- 2023
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55. Sex differences in muscle quality of firefighter recruits: a new exploratory approach to evaluation
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Perroni, Fabrizio, Cardinali, Ludovica, Cignitti, Lamberto, Amatori, Stefano, Rocchi, Marco B. L., Stocchi, Vilberto, Piccoli, Giovanni, Baldari, Carlo, Sisti, Davide, Guidetti, Laura, Vetrano, Mario, and Nusca, Sveva M.
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- 2023
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56. p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation
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Ludovica Lopresti, Nagaja Capitani, Vanessa Tatangelo, Carmela Tangredi, Gioia Boncompagni, Federica Frezzato, Andrea Visentin, Giuseppe Marotta, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Livio Trentin, Cosima T. Baldari, and Laura Patrussi
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PD-L1 ,immune checkpoint ,CLL ,p66Shc ,immune synapse ,ROS ,Biology (General) ,QH301-705.5 - Abstract
Introduction: Escape from immunosurveillance is a hallmark of chronic lymphocytic leukemia (CLL) cells. In the protective niche of lymphoid organs, leukemic cells suppress the ability of T lymphocytes to form the immune synapse (IS), thereby hampering T-cell mediated anti-tumoral activities. By binding its cognate receptor PD-1 at the surface of T lymphocytes, the inhibitory ligand PD-L1, which is overexpressed in CLL cells, mediates the T-cell suppressive activities of CLL cells. However, the molecular mechanism underlying PD-L1 overexpression in CLL cells remains unknown. We have previously reported a defective expression of the pro-apoptotic and pro-oxidant adaptor p66Shc in CLL cells, which is causally related to an impairment in intracellular reactive oxygen species (ROS) production and to the activation of the ROS-sensitive transcription factor NF-κB. The fact that PD-L1 expression is regulated by NF-κB suggests a mechanistic relationship between p66Shc deficiency and PD-L1 overexpression in CLL cells.Methods: 62 treatment-naive CLL patients and 43 healthy donors were included in this study. PD-L1 and p66Shc expression was quantified in B cells by flow cytometry and qRT-PCR. IS architecture and local signaling was assessed by flow cytometry and confocal microscopy. CD8+ cell killing activity was assessed by flow cytometry.Results: Here we show that residual p66Shc expression in leukemic cells isolated both from CLL patients and from the CLL mouse model Eμ-TCL1 inversely correlated with PD-L1 expression. We also show that the PD-L1 increase prevented leukemic cells from forming ISs with T lymphocytes. Reconstitution of p66Shc, but not of a ROS-defective mutant, in both CLL cells and the CLL-derived cell line MEC-1, enhanced intracellular ROS and decreased PD-L1 expression. Similar results were obtained following treatment of CLL cells with H2O2 as exogenous source of ROS, that normalized PD-L1 expression and recovered IS formation.Discussion: Our data provide direct evidence that the p66Shc-deficiency-related ROS depletion in CLL cells concurs to enhance PD-L1 expression and provides a mechanistic basis for the suppression of T cell-mediated anti-tumoral functions in the immunosuppressive lymphoid niche.
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- 2024
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57. Effects of sports experience on children's gross motor coordination level
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Valentina Biino, Valerio Giustino, Maria Chiara Gallotta, Marianna Bellafiore, Giuseppe Battaglia, Massimo Lanza, Carlo Baldari, Matteo Giuriato, Flavia Figlioli, Laura Guidetti, and Federico Schena
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sports practice ,gymnastics ,cycling ,athletics ,swimming ,BMI ,Sports ,GV557-1198.995 - Abstract
BackgroundGross motor coordination (GMC) development could be influenced by age, gender, weight status, geographical area, living setting, home environment, socio-economic status, sports practice.PurposeTo verify whether practicing sports and practicing different sports could influence children's GMC level.MethodsA total of 295 children aged 8–11 years were involved in the study and divided into 5 groups in relation to the sport they practiced: gymnastics group (n = 67; 51F, 16M), cycling group (n = 64; 15F, 49M), athletics group (n = 47; 22F, 25M), swimming group (n = 35; 20F, 15M), control group (n = 82; 42F, 40M). The four subtests of the Körperkoordinations Test für Kinder (KTK) assessed children's GMC level. The scores from each of the four subtests were summed into the KTK total raw score (RS) and then converted into a gender- and age-specific motor quotient (MQ).ResultsChildren practicing sports showed significantly higher RS and MQ score than children of control group (203.14 ± 38.55 vs. 163.63 ± 43.50 and 98.56 ± 15.79 vs. 83.01 ± 16.71, respectively; p
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- 2023
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58. Application of indocyanine green (ICG)-guided surgery in clinical practice: lesson to learn from other organs—an overview on clinical applications and future perspectives
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Cassinotti, E., Boni, L., and Baldari, L.
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- 2023
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59. Updating 90Y Voxel S-Values including internal Bremsstrahlung: Monte Carlo study and development of an analytical model
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Pistone, Daniele, Amato, Ernesto, Auditore, Lucrezia, Baldari, Sergio, and Italiano, Antonio
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- 2023
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60. iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis
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Lattanzi, Georgia, Strati, Francesco, Díaz-Basabe, Angélica, Perillo, Federica, Amoroso, Chiara, Protti, Giulia, Rita Giuffrè, Maria, Iachini, Luca, Baeri, Alberto, Baldari, Ludovica, Cassinotti, Elisa, Ghidini, Michele, Galassi, Barbara, Lopez, Gianluca, Noviello, Daniele, Porretti, Laura, Trombetta, Elena, Messuti, Eleonora, Mazzarella, Luca, Iezzi, Giandomenica, Nicassio, Francesco, Granucci, Francesca, Vecchi, Maurizio, Caprioli, Flavio, and Facciotti, Federica
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- 2023
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61. Internal Bremsstrahlung, the missing process in beta decay Monte Carlo simulation: The relevance in 32P Dose-Point-Kernel estimation
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Italiano, Antonio, Pistone, Daniele, Amato, Ernesto, Baldari, Sergio, and Auditore, Lucrezia
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- 2023
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62. The COVID - AGICT study: COVID–19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes
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Franco, Lorenzo De, Benigni, Roberto, Tribuzi, Angela, Marra, Ubaldo, Di Marino, Michele, Cova, Chiara, Bianchi, Beatrice, Nobile, Sara, Zorcolo, Luigi, Lisi, Giorgio, Allisiardi, Fabrizio, Grieco, Michele, Righetti, Carolina, Frisini, Marco, Brolese, Alberto, Grassia, Michele, Lucchi, Andrea, Bagaglini, Giulia, Sica, Giuseppe S., Manara, Michele, Turati, Luca, Macone, Lorenzo, Carminati, Roberta, Mariani, Pierpaolo, Rizzo, Gianluca, Coco, Claudio, Pennella, Francesca Pennetti, Rondelli, Fabio, Romano, Lucia, Giuliani, Antonio, Palaia, Raffaele, Belli, Andrea, Albino, Vittorio, Leongito, Maddalena, David, Giulia, Misitano, Pasquale, Pasulo, Silvia, Baiocchi, Gian Luca, La Mendola, Roberta, Hilal, Mohamnad Abu, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Capolupo, Gabriella Teresa, Caricato, Marco, Pinotti, Enrico, Montuori, Mauro, Bombardini, Cristina, Anania, Gabriele, Dibra, Rigers, Martines, Gennaro, Solaini, Leonardo, Ercolani, Giorgio, Oliva, Renato, Carati, Maria Vittoria, Grazi, Gian Luca, Ghio, Giacomo, Marchegiani, Francesco, Pucciarelli, Salvatore, La Torre, Filippo, Iannone, Immacolata, Krizzuk, Dimitri, Sammartino, Francesco, Catalano, Giorgia, Strignano, Paolo, Romagnoli, Renato, Piccione, Domenico, Nardo, Bruno, Reddavid, Rossella, Degiuli, Maurizio, Gerosa, Martino, Maggioni, Dario, Zuolo, Michele, Rigamonti, Marco, Ghazouani, Omar, Galleano, Raffaele, Percivale, Andrea, Tirloni, Luca, Moraldi, Luca, Fabbri, Nicolò, Feo, Carlo Vittorio, Colombo, Samuele, Di Saverio, Salomone, Barbato, Giuseppe, Coratti, Francesco, Sagnotta, Andrea, Mancini, Stefano, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Formisano, Giampaolo, Giuliani, Giuseppe, Guerra, Francesco, Messinese, Simona, Santelli, Francesco, Salvischiani, Lucia, Esposito, Sofia, Ferraro, Luca, Esposito, Alessandro, De Pastena, Matteo, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Kauffmann, Emanuele Federico, Boggi, Ugo, Deidda, Simona, Restivo, Angelo, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Depalma, Norma, D'Ugo, Stefano, Spampinato, Marcello, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Turri, Giulia, Pedrazzani, Corrado, Zese, Monica, Parini, Dario, Casaril, Andrea, Moretto, Gianluigi, De Leo, Antonio, Catarci, Marco, Trapani, Renza, Zonta, Sandro, Marsanic, Patrizia, Muratore, Andrea, Di Franco, Gregorio, Morelli, Luca, Coppola, Alessandro, Caputo, Damiano, Andreuccetti, Jacopo, Pignata, Giusto, Mastrangelo, Laura, Jovine, Elio, Mazzola, Michele, Ferrari, Giovanni, Mariani, Lorenzo, Ceccarelli, Graziano, Giuseppe, Rocco, Bolzon, Stefano, Grasso, Mariateresa, Testa, Silvio, Germani, Paola, de Manzini, Nicolò, Langella, Serena, Ferrero, Alessandro, Coletta, Diego, Bianchi, Paolo Pietro, Bengala, Carmelo, and Coratti, Andrea
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- 2023
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63. Porto-spleno-mesenteric venous thrombosis after elective splenectomy: a retrospective cohort study
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Ludovica Baldari, Luigi Boni, Beatrice Giuliani, and Elisa Cassinotti
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porto-spleno-mesenteric venous thrombosis ,portal thrombosis ,splenic thrombosis ,splenectomy ,splenectomy complications ,hematological disorders ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundElective splenectomy is the main treatment for a wide range of haematological diseases. Porto-spleno-mesenteric venous thrombosis represents one of the most severe complications of this procedure. The aim of this study was to evaluate risk factors associated with development of porto-spleno-mesenteric venous thrombosis after elective splenectomy.MethodsAll cases of elective splenectomy carried out from April 1st 2017 to January 31st 2023 were included in this single centre retrospective cohort study. Patients’ demographics and perioperative data were analysed and correlated with the incidence of postoperative thrombosis. All patients underwent postoperative doppler ultrasound screening for thrombosis. Analysis was performed using SPSS 28, with p-value < 0.05 considered significant.ResultsTwenty-two patients (10 women, 12 men) underwent splenectomy during the study period. Indications were: immune thrombocytopenia (n: 6), myeloproliferative disorder (n: 6), hereditary spherocytosis (n: 4), thalassemia (n: 1), lymphoma (n: 1), leukaemia (n: 1), other malignancies (n: 3). Six patients developed porto-spleno-mesenteric venous thrombosis and only 2 of them were symptomatic. Patients were treated with anticoagulation therapy with complete resolution. Analysis identified three main factors associated with thrombosis: spleen diameter (p = 0.03), myeloproliferative disorder (p = 0.02), intraoperative platelet transfusion (p = 0.002) and intraoperative red blood cells transfusion (p = 0.009).ConclusionStandardized postoperative screening allows prompt diagnosis and treatment of porto-spleno-mesenteric venous thrombosis even in asymptomatic cases. Patient with splenomegaly and affected by myeloproliferative disorder have a greater risk to develop this complication.
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- 2023
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64. Integrated Science 2050: Multidisciplinarity and Interdisciplinarity in Health
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Rezaei, Nima, Saghazadeh, Amene, Ghani, Abdul Rahman Izaini, Vedadhir, AbouAli, Vahed, Aida, Vellido, Alfredo, Afshar, Alireza, Zali, Alireza, Kushniruk, Andre, Blacutt, Andrée-Anne, Pennisi, Antonino, Condino-Neto, Antonio, Khojasteh, Arash, Soto-Rojas, Armando E., Brown, Brian, Velasques, Bruna, Lucchiari, Claudio, Atilano-Barbosa, Daniel, Aprígio, Danielle, Kirsch, Donald R., Chiricò, Donata, Rayzan, Elham, Karakoc-Aydiner, Elif, Borycki, Elizabeth, Palmerini, Emilio Maria, Balogh, Esther A., Minutoli, Fabio, Ghobadinezhad, Farbod, Farrokhi, Farid, Reza, Faruque, Young, Gerald, Sierpiński, Grzegorz, Sajadi, Haniye Sadat, Ochs, Hans D., Murtomaa, Heikki, Monkman, Helen, Mojtabavi, Helia, Tonelli, Hélio A., Ziaei, Heliya, Sakly, Houneida, Jho, Hunkoog, Celiński, Ireneusz, Abdullah, Jafri Malin, Šrol, Jakub, Seekins, Jayne, Ravetz, Joe, Periñán, Juan José Garrido, Bittencourt, Juliana, Sarkar, Kaushik, Saleki, Kiarash, de Siqueira Rotenberg, Luisa, Jamee, Mahnaz, Keshavarz-Fathi, Mahsa, Gongora, Mariana, Cagy, Mauricio, Akhlaghdoust, Meisam, Lotfi, Melika, Baziar, Milad, Rafiaei, Milad, Amin Khazeei Tabari, Mohammad, Khami, Mohammad R., Golabchi, Mohammad Rasoul, Fadavipour, Mohammadreza, Tagina, Moncef, Lakhanpaul, Monica, Folayan, Morenike Oluwatoyin, Shamsizadeh, Morteza, Said, Mourad, Rambod Rad, Niloofar, Yazdanpanah, Niloufar, Samieefar, Noosha, Ribeiro, Pedro, Phantumvanit, Prathip, Parikh, Priti, van de Pas, Remco, Majdzadeh, Reza, Laudicella, Riccardo, Stein, Richard A., Mercadillo, Roberto E., Kelishadi, Roya, Behrouzieh, Sadra, Afkham, Saina Adiban, Momtazmanesh, Sara, Hosseini, Sayedeh Azimeh, Baldari, Sergio, Teixeira, Silmar, Seyedpour, Simin, Roche, Stéphane, Kekeghe, Stephen E., Feldman, Steven R., Fernandes, Thayaná, Ulrichs, Timo, Dorigo, Tommaso, Roudenok, Vasili, Iyer, Veeraraghavan J., Emmerich, Veronica K., Marinho, Victor, Čavojová, Vladimíra, Al-Herz, Waleed, Pirkoohi, Zahra Rahimi, Zakaria, Zaitun, Idris, Zamzuri, Izadi, Zhila, and Rezaei, Nima, Editor-in-Chief
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- 2022
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65. Nuclear Medicine: A Transdisciplinary Field to Integrate Formal, Physical, Biological, and Medical Sciences
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Baldari, Sergio, Minutoli, Fabio, Laudicella, Riccardo, and Rezaei, Nima, Editor-in-Chief
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- 2022
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66. Multicentric validation of EndoDigest: a computer vision platform for video documentation of the critical view of safety in laparoscopic cholecystectomy
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Mascagni, Pietro, Alapatt, Deepak, Laracca, Giovanni Guglielmo, Guerriero, Ludovica, Spota, Andrea, Fiorillo, Claudio, Vardazaryan, Armine, Quero, Giuseppe, Alfieri, Sergio, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Cuccurullo, Diego, Costamagna, Guido, Dallemagne, Bernard, and Padoy, Nicolas
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- 2022
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67. Small Bowel Neuroendocrine Tumors: Focus on Pathologic Aspects and Controversial Surgical Issues
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Pino, Antonella, Frattini, Francesco, Ieni, Antonio, Colombo, Carla, De Leo, Simone, Rausei, Stefano, Boni, Luigi, Lianos, Georgios, Fadda, Guido, Yub, Kim Hoon, Baldari, Sergio, Campennì, Alfredo, and Dionigi, Gianlorenzo
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- 2022
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68. Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes
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Capitani, Nagaja, primary, Cassioli, Chiara, additional, Ravichandran, Keerthana, additional, and Baldari, Cosima T., additional
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- 2023
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69. Dysfunctional Immune Synapses in T Cell Immunodeficiencies
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Capitani, Nagaja, Patrussi, Laura, D’Elios, Mario Milco, Baldari, Cosima Tatiana, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima Tatiana, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, Vaglio, Augusto, Editorial Board Member, and Annunziato, Francesco, editor
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- 2021
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70. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
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Cossarizza, Andrea, Chang, Hyun-Dong, Radbruch, Andreas, Acs, Andreas, Adam, Dieter, Adam-Klages, Sabine, Agace, William W, Aghaeepour, Nima, Akdis, Mübeccel, Allez, Matthieu, Almeida, Larissa Nogueira, Alvisi, Giorgia, Anderson, Graham, Andrä, Immanuel, Annunziato, Francesco, Anselmo, Achille, Bacher, Petra, Baldari, Cosima T, Bari, Sudipto, Barnaba, Vincenzo, Barros-Martins, Joana, Battistini, Luca, Bauer, Wolfgang, Baumgart, Sabine, Baumgarth, Nicole, Baumjohann, Dirk, Baying, Bianka, Bebawy, Mary, Becher, Burkhard, Beisker, Wolfgang, Benes, Vladimir, Beyaert, Rudi, Blanco, Alfonso, Boardman, Dominic A, Bogdan, Christian, Borger, Jessica G, Borsellino, Giovanna, Boulais, Philip E, Bradford, Jolene A, Brenner, Dirk, Brinkman, Ryan R, Brooks, Anna ES, Busch, Dirk H, Büscher, Martin, Bushnell, Timothy P, Calzetti, Federica, Cameron, Garth, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L, Casola, Stefano, Cassatella, Marco A, Cavani, Andrea, Celada, Antonio, Chatenoud, Lucienne, Chattopadhyay, Pratip K, Chow, Sue, Christakou, Eleni, Čičin-Šain, Luka, Clerici, Mario, Colombo, Federico S, Cook, Laura, Cooke, Anne, Cooper, Andrea M, Corbett, Alexandra J, Cosma, Antonio, Cosmi, Lorenzo, Coulie, Pierre G, Cumano, Ana, Cvetkovic, Ljiljana, Dang, Van Duc, Dang-Heine, Chantip, Davey, Martin S, Davies, Derek, De Biasi, Sara, Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Delacher, Michael, Della Bella, Silvia, Dellabona, Paolo, Deniz, Günnur, Dessing, Mark, Di Santo, James P, Diefenbach, Andreas, Dieli, Francesco, Dolf, Andreas, Dörner, Thomas, Dress, Regine J, Dudziak, Diana, Dustin, Michael, Dutertre, Charles-Antoine, Ebner, Friederike, Eckle, Sidonia BG, Edinger, Matthias, Eede, Pascale, Ehrhardt, Götz RA, Eich, Marcus, Engel, Pablo, Engelhardt, Britta, and Erdei, Anna
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1.1 Normal biological development and functioning ,Underpinning research ,Inflammatory and immune system ,Allergy and Immunology ,Cell Separation ,Consensus ,Flow Cytometry ,Humans ,Phenotype ,Immunology - Abstract
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
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- 2019
71. Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells.
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Baldari, Silvia, Di Rocco, Giuliana, Heffern, Marie C, Su, Timothy A, Chang, Christopher J, and Toietta, Gabriele
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BRAF ,BRAFV600E mutation ,chelating agents ,colon cancer ,copper ,mitogen-activated protein kinase ,tetrathiomolybdate ,BRAF(V600E) mutation ,Prevention ,Cancer ,Digestive Diseases ,Colo-Rectal Cancer ,2.1 Biological and endogenous factors ,5.1 Pharmaceuticals ,Oncology and Carcinogenesis - Abstract
High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal regulated kinases 1 and 2 (ERK1/2). Consequently, copper-dependent activation of the mitogen-activated (MAP) kinase pathway has a role in promoting tumor growth. Conversely, copper chelation may represent a possible therapeutic approach for a specific subset of tumors characterized by activating mutations in the serine/threonine protein kinase V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF), such as the V600E, occurring within the kinase domain (BRAFV600E). Tetrathiomolybdate (TM) is a specific copper chelating agent currently used for the treatment of Wilson's disease and in preclinical studies for the management of metastatic cancers owing to its anti-angiogenic and anti-inflammatory properties. We evaluated in vitro and in vivo the effects of copper depletion achieved by pharmacological treatment with TM in human colorectal cells bearing the BRAFV600E mutation in comparison with BRAF wild type cells. We provide evidence that selective copper chelation differentially affects proliferation, survival and migration of colon cancer cells bearing the BRAFV600E mutation compared to BRAFwt acting via differential phosphorylation levels of ERK1/2. Moreover, tetrathiomolybdate treatment was also effective in reducing the clonogenic potential of colon cancer BRAFV600E cells resistant to BRAF pharmacological inhibition. In conclusion, these results support further assessment of copper chelation therapy as an adjuvant therapy for inhibiting the progression of colon cancers containing the BRAFV600E mutation.
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- 2019
72. Prostate Cancer Biochemical Recurrence Resulted Negative on [68Ga]Ga-PSMA-11 but Positive on [18F]Fluoromethylcholine PET/CT
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Riccardo Laudicella, Flavia La Torre, Valerio Davì, Ludovica Crocè, Demetrio Aricò, Giuseppe Leonardi, Simona Russo, Fabio Minutoli, Irene A. Burger, and Sergio Baldari
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prostate cancer ,PET ,PSMA ,choline ,biochemical recurrence ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
For prostate cancer (PCa) biochemical recurrence (BCR), the primarily suggested imaging technique by the European Association of Urology (EAU) guidelines is prostate-specific membrane antigen (PSMA) positron emission tomography/computer tomography (PET/CT). Indeed, the increased detection rate of PSMA PET/CT for early BCR has led to a fast and wide acceptance of this novel technology. However, PCa is a very heterogeneous disease, not always easily assessable with the highly specific PSMA PET with around 10% of cases occuring without PSMA expression. In this paper, we present the case of a patient with PCa BCR that resulted negative on [68Ga]Ga-PSMA-11 PET/CT, but positive on [18F]Fluoromethylcholine (Choline) PET/CT.
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- 2022
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73. Narrative identity among people with disabilities in the United States during the Covid-19 pandemic: The interdependent self
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Adler, Jonathan M., Manning, Robert B., III, Hennein, Rachel, Winschel, Julia, Baldari, Alessandra, Bogart, Kathleen R., Nario-Redmond, Michelle R., Ostrove, Joan M., Lowe, Sarah R., and Wang, Katie
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- 2022
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74. hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC
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Sarah Warren, Paola Nisticò, Federico Cappuzzo, Federica Marchesi, Isabella Sperduti, Silvia Carpano, Francesca De Nicola, Frauke Goeman, Lorenzo D'Ambrosio, Vanesa Gregorc, Claudio Tripodo, Vincenzo Russo, Paolo Visca, Francesca Paolini, Paola Trono, Annalisa Tocci, Belinda Palermo, Anna Di Carlo, Daniel D'Andrea, Francesca Di Modugno, Giacomo Corleone, Mariangela Panetta, Silvia Baldari, and Paolo Zucali
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Understanding how cancer signaling pathways promote an immunosuppressive program which sustains acquired or primary resistance to immune checkpoint blockade (ICB) is a crucial step in improving immunotherapy efficacy. Among the pathways that can affect ICB response is the interferon (IFN) pathway that may be both detrimental and beneficial. The immune sensor retinoic acid-inducible gene I (RIG-I) induces IFN activation and secretion and is activated by actin cytoskeleton disturbance. The actin cytoskeleton regulatory protein hMENA, along with its isoforms, is a key signaling hub in different solid tumors, and recently its role as a regulator of transcription of genes encoding immunomodulatory secretory proteins has been proposed. When hMENA is expressed in tumor cells with low levels of the epithelial specific hMENA11a isoform, identifies non-small cell lung cancer (NSCLC) patients with poor prognosis. Aim was to identify cancer intrinsic and extrinsic pathways regulated by hMENA11a downregulation as determinants of ICB response in NSCLC. Here, we present a potential novel mechanism of ICB resistance driven by hMENA11a downregulation.Methods Effects of hMENA11a downregulation were tested by RNA-Seq, ATAC-Seq, flow cytometry and biochemical assays. ICB-treated patient tumor tissues were profiled by Nanostring IO 360 Panel enriched with hMENA custom probes. OAK and POPLAR datasets were used to validate our discovery cohort.Results Transcriptomic and biochemical analyses demonstrated that the depletion of hMENA11a induces IFN pathway activation, the production of different inflammatory mediators including IFNβ via RIG-I, sustains the increase of tumor PD-L1 levels and activates a paracrine loop between tumor cells and a unique macrophage subset favoring an epithelial-mesenchymal transition (EMT). Notably, when we translated our results in a clinical setting of NSCLC ICB-treated patients, transcriptomic analysis revealed that low expression of hMENA11a, high expression of IFN target genes and high macrophage score identify patients resistant to ICB therapy.Conclusions Collectively, these data establish a new function for the actin cytoskeleton regulator hMENA11a in modulating cancer cell intrinsic type I IFN signaling and extrinsic mechanisms that promote protumoral macrophages and favor EMT. These data highlight the role of actin cytoskeleton disturbance in activating immune suppressive pathways that may be involved in resistance to ICB in NSCLC.
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- 2023
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75. Editorial: Community series in adaptor molecules in T cell signaling, volume II
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Sutatip Pongcharoen, Anne Spurkland, and Cosima T. Baldari
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T cell ,adaptor molecules ,TCR signaling ,signal transduction ,T cell receptor ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2023
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76. Corrigendum: TMEM123 a key player in immune surveillance of colorectal cancer
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Elisa Pesce, Chiara Cordiglieri, Mauro Bombaci, Serenella Eppenberger-Castori, Stefania Oliveto, Cristina Manara, Mariacristina Crosti, Caner Ercan, Mairene Coto, Andrea Gobbini, Susanna Campagnoli, Tiziano Donnarumma, Manuele Martinelli, Valeria Bevilacqua, Elisa De Camilli, Paola Gruarin, Maria L. Sarnicola, Elisa Cassinotti, Ludovica Baldari, Giuseppe Viale, Stefano Biffo, Sergio Abrignani, Luigi M. Terracciano, and Renata Grifantini
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colorectal cancer ,tumor microenvironment ,tumor-infiltrating lymphocytes ,TMEM123 ,cytoskeleton organization ,cell adhesion ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2023
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77. TMEM123 a key player in immune surveillance of colorectal cancer
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Elisa Pesce, Chiara Cordiglieri, Mauro Bombaci, Serenella Eppenberger-Castori, Stefania Oliveto, Cristina Manara, Mariacristina Crosti, Caner Ercan, Mairene Coto, Andrea Gobbini, Susanna Campagnoli, Tiziano Donnarumma, Manuele Martinelli, Valeria Bevilacqua, Elisa De Camilli, Paola Gruarin, Maria L. Sarnicola, Elisa Cassinotti, Ludovica Baldari, Giuseppe Viale, Stefano Biffo, Sergio Abrignani, Luigi M. Terracciano, and Renata Grifantini
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colorectal cancer ,tumor microenvironment ,tumor-infiltrating lymphocytes ,TMEM123 ,cytoskeleton organization ,cell adhesion ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells determines the balance between tumor elimination or outgrowth. We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 and CD8 T lymphocytes and it contributes to their effector phenotype. The presence of infiltrating TMEM123+ CD8+ T cells is associated with better overall and metastasis-free survival. TMEM123 localizes in the protrusions of infiltrating T cells, it contributes to lymphocyte migration and cytoskeleton organization. TMEM123 silencing modulates the underlying signaling pathways dependent on the cytoskeletal regulator WASP and the Arp2/3 actin nucleation complex, which are required for synaptic force exertion. Using tumoroid-lymphocyte co-culture assays, we found that lymphocytes form clusters through TMEM123, anchoring to cancer cells and contributing to their killing. We propose an active role for TMEM123 in the anti-cancer activity of T cells within tumour microenvironment.
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- 2023
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78. Which physical activity in patients affected by hypoparathyroidism? A review of the literature and practical recommendations
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Bonavolontà, V., Cianferotti, L., Iolascon, G., Moretti, A., Brandi, M. L., Fischetti, F., Lenzi, A., Baldari, C., and Migliaccio, S.
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- 2022
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79. Duodenal hematoma in pediatric age: a rare case report
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Brillantino, Carmela, Rossi, Eugenio, Baldari, Diana, Minelli, Rocco, Bignardi, Elio, Paviglianiti, Giuseppe, Restivo, Giulia, Cangemi, Maria A., Zeccolini, Raffaele, and Zeccolini, Massimo
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- 2022
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80. Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion
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Díaz-Basabe, A, Lattanzi, G, Perillo, F, Amoroso, C, Baeri, A, Farini, A, Torrente, Y, Penna, G, Rescigno, M, Ghidini, M, Cassinotti, E, Baldari, L, Boni, L, Vecchi, M, Caprioli, F, Facciotti, F, Strati, F, Díaz-Basabe A., Lattanzi G., Perillo F., Amoroso C., Baeri A., Farini A., Torrente Y., Penna G., Rescigno M., Ghidini M., Cassinotti E., Baldari L., Boni L., Vecchi M., Caprioli F., Facciotti F., Strati F., Díaz-Basabe, A, Lattanzi, G, Perillo, F, Amoroso, C, Baeri, A, Farini, A, Torrente, Y, Penna, G, Rescigno, M, Ghidini, M, Cassinotti, E, Baldari, L, Boni, L, Vecchi, M, Caprioli, F, Facciotti, F, Strati, F, Díaz-Basabe A., Lattanzi G., Perillo F., Amoroso C., Baeri A., Farini A., Torrente Y., Penna G., Rescigno M., Ghidini M., Cassinotti E., Baldari L., Boni L., Vecchi M., Caprioli F., Facciotti F., and Strati F.
- Abstract
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells. However, the impact of other bacteria associated with CRC, like Porphyromonas gingivalis, on their activation status remains unexplored. In this study, we demonstrate that mucosa-associated P. gingivalis induces a protumour phenotype in iNKT cells, subsequently influencing the composition of mononuclear-phagocyte cells within the tumor microenvironment. Mechanistically, in vivo and in vitro experiments showed that P. gingivalis reduces the cytotoxic functions of iNKT cells, hampering the iNKT cell lytic machinery through increased expression of chitinase 3-like-1 protein (CHI3L1). Neutralization of CHI3L1 effectively restores iNKT cell cytotoxic functions suggesting a therapeutic potential to reactivate iNKT cell-mediated antitumour immunity. In conclusion, our data demonstrate how P. gingivalis accelerates CRC progression by inducing the upregulation of CHI3L1 in iNKT cells, thus impairing their cytotoxic functions and promoting host tumor immune evasion.
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- 2024
81. Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study
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Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, Palisi, M, Danese, F, Cherubini, V, Perotti, S, Carvello, M, Carbone, F, Luberto, A, Calafiore, E, De Lucia, F, Sacchi, M, Sasia, D, Giuffrida, M, Ballauri, E, Cardile, M, Armentano, S, Beltrami, E, Preve, G, Vercellone, B, Mozzon, M, Folliero, C, Lirusso, C, Vecchiato, M, Ziccarelli, A, Gattesco, D, Moretti, L, Crestale, S, Banchini, F, Capelli, P, Romboli, A, Palmieri, G, Conti, L, Rizzi, N, Bonfili, D, De Manzini, N, Germani, P, Osenda, E, Cortinovis, S, Giunta, C, Fracon, S, Abdallah, H, Bogoni, S, Portolani, N, Nascimbeni, R, Molfino, S, Tiberio, G, Garosio, I, Lamperti, G, Rigosa, D, Ercolani, G, Solaini, L, Cavaliere, D, Avanzolini, A, D'Acapito, F, Chiarella, L, Di Pietrantonio, D, Annunziata, D, Piccolo, R, Sorrentino, M, Pansini, M, Cojutti, A, Graziano, M, Callegari, F, Balzarotti, L, Dameno, V, Cattaneo, A, Santolamazza, G, Altieri, C, Magarini, R, Pietrabissa, A, Dominioni, T, Pugliese, L, Peri, A, Botti, M, Salvetti, F, Boni, L, Cassinotti, E, Baldari, L, Messina, V, D'Abrosca, V, Cianci, P, Tumolo, R, Gattulli, D, Restini, E, Minafra, M, Sederino, M, Bottalico, B, Pilati, P, Franzato, B, Mattara, G, De Simoni, O, Barina, A, Tonello, M, Muratore, A, Calabro, M, Federico Pipitone, N, Cuzzola, B, Van Nood, E, Passuello, N, Frasson, A, Mammano, E, Faccio, L, Vittadello, F, Bressan, A, Sarzo, G, Tamini, N, Oldani, M, Cigagna, L, Carissimi, F, De Carlo, G, Baccalini, E, Nespoli, L, Giordano, A, Cantafio, S, Grifoni, L, Matani, D, Livi, S, Delogu, D, Scognamillo, F, Marrosu, A, Guerrini, L, Ugolini, G, Ghignone, F, Frascaroli, G, Albertini, N, Zattoni, D, Taffurelli, G, Montroni, I, Colombo, F, Danelli, P, Bondurri, A, Maffioli, A, Bonomi, A, Pezzoli, I, Cammarata, F, Goletti, O, Molteni, M, Assisi, A, Quartierini, G, Da Lio, C, Verdi, D, Mondi, I, Peluso, C, Macchi, L, Tanzanu, M, Zanzi, F, Pellegrini, S, Andreuccetti, J, D'Alessio, R, Pignata, G, De Capua, M, Canfora, I, Ottaviani, L, Lepiane, P, Balla, A, De Carlo, A, Saraceno, F, Scaramuzzo, R, Guida, A, Aguzzi, D, Bellora, P, Gentilli, S, Monni, M, Nikaj, H, Cillara, N, Cannavera, A, Deserra, A, Margiani, C, Cabula, R, Dettori, M, Gramignano, G, Lezoche, G, Ortenzi, M, Orlandoni, E, Curzi, F, Vitali, F, Capomagi, P, Palmieri, M, Del Rio, P, Bonati, E, Loderer, T, Cozzani, F, Rossini, M, Agnesi, S, Capolupo, G, Caricato, M, Carannante, F, Masciana, G, Marrelli, M, Miacci, V, Lauricella, S, Tonini, V, Cervellera, M, Pisconti, S, Lozito, C, Shahu, J, Mongelli, C, Morelli, G, Sartarelli, L, Sica, G, Siragusa, L, Bagaglini, G, Franceschilli, M, Bellato, V, Fiorani, C, Taddei, A, Risaliti, M, Bartolini, I, Ringressi, M, Tirloni, L, Laface, L, Abate, E, Casati, M, Gobbi, P, Opocher, E, Mariani, N, Ceretti, A, Giovenzana, M, Giuliani, B, Sironi, M, Grossi, U, Zanus, G, Santoro, G, Brizzolari, M, De Leo, E, Novello, S, Aquilino, K, Milardi, F, Olmi, S, Uccelli, M, Bonaldi, M, Cesana, G, Bindi, M, Galleano, R, Langone, A, Botto, M, Franceschi, A, Gambino, E, Ronconi, M, Casiraghi, S, Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., Celentano V., Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, Palisi, M, Danese, F, Cherubini, V, Perotti, S, Carvello, M, Carbone, F, Luberto, A, Calafiore, E, De Lucia, F, Sacchi, M, Sasia, D, Giuffrida, M, Ballauri, E, Cardile, M, Armentano, S, Beltrami, E, Preve, G, Vercellone, B, Mozzon, M, Folliero, C, Lirusso, C, Vecchiato, M, Ziccarelli, A, Gattesco, D, Moretti, L, Crestale, S, Banchini, F, Capelli, P, Romboli, A, Palmieri, G, Conti, L, Rizzi, N, Bonfili, D, De Manzini, N, Germani, P, Osenda, E, Cortinovis, S, Giunta, C, Fracon, S, Abdallah, H, Bogoni, S, Portolani, N, Nascimbeni, R, Molfino, S, Tiberio, G, Garosio, I, Lamperti, G, Rigosa, D, Ercolani, G, Solaini, L, Cavaliere, D, Avanzolini, A, D'Acapito, F, Chiarella, L, Di Pietrantonio, D, Annunziata, D, Piccolo, R, Sorrentino, M, Pansini, M, Cojutti, A, Graziano, M, Callegari, F, Balzarotti, L, Dameno, V, Cattaneo, A, Santolamazza, G, Altieri, C, Magarini, R, Pietrabissa, A, Dominioni, T, Pugliese, L, Peri, A, Botti, M, Salvetti, F, Boni, L, Cassinotti, E, Baldari, L, Messina, V, D'Abrosca, V, Cianci, P, Tumolo, R, Gattulli, D, Restini, E, Minafra, M, Sederino, M, Bottalico, B, Pilati, P, Franzato, B, Mattara, G, De Simoni, O, Barina, A, Tonello, M, Muratore, A, Calabro, M, Federico Pipitone, N, Cuzzola, B, Van Nood, E, Passuello, N, Frasson, A, Mammano, E, Faccio, L, Vittadello, F, Bressan, A, Sarzo, G, Tamini, N, Oldani, M, Cigagna, L, Carissimi, F, De Carlo, G, Baccalini, E, Nespoli, L, Giordano, A, Cantafio, S, Grifoni, L, Matani, D, Livi, S, Delogu, D, Scognamillo, F, Marrosu, A, Guerrini, L, Ugolini, G, Ghignone, F, Frascaroli, G, Albertini, N, Zattoni, D, Taffurelli, G, Montroni, I, Colombo, F, Danelli, P, Bondurri, A, Maffioli, A, Bonomi, A, Pezzoli, I, Cammarata, F, Goletti, O, Molteni, M, Assisi, A, Quartierini, G, Da Lio, C, Verdi, D, Mondi, I, Peluso, C, Macchi, L, Tanzanu, M, Zanzi, F, Pellegrini, S, Andreuccetti, J, D'Alessio, R, Pignata, G, De Capua, M, Canfora, I, Ottaviani, L, Lepiane, P, Balla, A, De Carlo, A, Saraceno, F, Scaramuzzo, R, Guida, A, Aguzzi, D, Bellora, P, Gentilli, S, Monni, M, Nikaj, H, Cillara, N, Cannavera, A, Deserra, A, Margiani, C, Cabula, R, Dettori, M, Gramignano, G, Lezoche, G, Ortenzi, M, Orlandoni, E, Curzi, F, Vitali, F, Capomagi, P, Palmieri, M, Del Rio, P, Bonati, E, Loderer, T, Cozzani, F, Rossini, M, Agnesi, S, Capolupo, G, Caricato, M, Carannante, F, Masciana, G, Marrelli, M, Miacci, V, Lauricella, S, Tonini, V, Cervellera, M, Pisconti, S, Lozito, C, Shahu, J, Mongelli, C, Morelli, G, Sartarelli, L, Sica, G, Siragusa, L, Bagaglini, G, Franceschilli, M, Bellato, V, Fiorani, C, Taddei, A, Risaliti, M, Bartolini, I, Ringressi, M, Tirloni, L, Laface, L, Abate, E, Casati, M, Gobbi, P, Opocher, E, Mariani, N, Ceretti, A, Giovenzana, M, Giuliani, B, Sironi, M, Grossi, U, Zanus, G, Santoro, G, Brizzolari, M, De Leo, E, Novello, S, Aquilino, K, Milardi, F, Olmi, S, Uccelli, M, Bonaldi, M, Cesana, G, Bindi, M, Galleano, R, Langone, A, Botto, M, Franceschi, A, Gambino, E, Ronconi, M, Casiraghi, S, Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., and Celentano V.
- Abstract
Background: The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy. Methods: Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018-2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of ≥ 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site. Results: LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15-1.096, P = 0.003). The rate of ≥ 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56-0.85, P < 0.001) and MEDIUM-volume (OR 0.72, 95% c.i. 0.62-0.83, P < 0.001) centres was lower than in VERY HIGH-volume centres. Of the 4676 rectal cancer patients, the rate of ≥ 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41-0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56-0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60-0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52-0.94, P = 0.019) volume centres (vs. VERY HIGH). Conclusion: Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes.
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- 2024
82. Radiomics and artificial intelligence in prostate cancer: new tools for molecular hybrid imaging and theragnostics
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Virginia Liberini, Riccardo Laudicella, Michele Balma, Daniele G. Nicolotti, Ambra Buschiazzo, Serena Grimaldi, Leda Lorenzon, Andrea Bianchi, Simona Peano, Tommaso Vincenzo Bartolotta, Mohsen Farsad, Sergio Baldari, Irene A. Burger, Martin W. Huellner, Alberto Papaleo, and Désirée Deandreis
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Prostate cancer ,Positron emission tomography ,Artificial intelligence ,Radiomics ,Theragnostics ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract In prostate cancer (PCa), the use of new radiopharmaceuticals has improved the accuracy of diagnosis and staging, refined surveillance strategies, and introduced specific and personalized radioreceptor therapies. Nuclear medicine, therefore, holds great promise for improving the quality of life of PCa patients, through managing and processing a vast amount of molecular imaging data and beyond, using a multi-omics approach and improving patients’ risk-stratification for tailored medicine. Artificial intelligence (AI) and radiomics may allow clinicians to improve the overall efficiency and accuracy of using these “big data” in both the diagnostic and theragnostic field: from technical aspects (such as semi-automatization of tumor segmentation, image reconstruction, and interpretation) to clinical outcomes, improving a deeper understanding of the molecular environment of PCa, refining personalized treatment strategies, and increasing the ability to predict the outcome. This systematic review aims to describe the current literature on AI and radiomics applied to molecular imaging of prostate cancer.
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- 2022
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83. Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
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Federico, Stefano, Khan, Tuhina, Fontana, Anna, Brogi, Simone, Benedetti, Rosaria, Sarno, Federica, Carullo, Gabriele, Pezzotta, Alex, Saraswati, Akella Prasanth, Passaro, Eugenia, Pozzetti, Luca, Papa, Alessandro, Relitti, Nicola, Gemma, Sandra, Butini, Stefania, Pistocchi, Anna, Ramunno, Anna, Vincenzi, Fabrizio, Varani, Katia, Tatangelo, Vanessa, Patrussi, Laura, Baldari, Cosima T., Saponara, Simona, Gorelli, Beatrice, Lamponi, Stefania, Valoti, Massimo, Saccoccia, Fulvio, Giannaccari, Marialaura, Ruberti, Giovina, Herp, Daniel, Jung, Manfred, Altucci, Lucia, and Campiani, Giuseppe
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- 2022
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84. Estrogen-related differences in antitumor immunity and gut microbiome contribute to sexual dimorphism of colorectal cancer.
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Lattanzi, Georgia, Perillo, Federica, Díaz-Basabe, Angélica, Caridi, Bruna, Amoroso, Chiara, Baeri, Alberto, Cirrincione, Elisa, Ghidini, Michele, Galassi, Barbara, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Vecchi, Maurizio, Caprioli, Flavio, Facciotti, Federica, and Strati, Francesco
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CYTOTOXIC T cells ,TUMOR-infiltrating immune cells ,GENDER medicine ,GUT microbiome ,SEXUAL dimorphism ,AGE factors in cancer - Abstract
Colorectal cancer (CRC) is a multifaceted disease whose development and progression varies depending on tumor location, age of patients, infiltration of immune cells within cancer lesions, and the tumor microenvironment. These pathophysiological characteristics are additionally influenced by sex-related differences. The gut microbiome plays a role in initiation and progression of CRC, and shapes anti-tumor immune responses but how responsiveness of the immune system to the intestinal microbiota may contribute to sexual dimorphism of CRC is largely unknown. We studied survival, tumor-infiltrating immune cell populations and tumor-associated microbiome of a cohort of n = 184 male and female CRC patients through high-dimensional single-cell flow cytometry and 16S rRNA gene sequencing. We functionally tested the immune system-microbiome interactions in in-vivo and in-vitro models of the disease. High-dimensional single-cell flow cytometry showed that female patients are enriched by tumor-infiltrating invariant Natural Killer T (iNKT) cells but depleted by cytotoxic T lymphocytes. The enrichment of oral pathobionts and a reduction of β-glucuronidase activity are distinctive traits characterizing the gut microbiome of female patients affected by CRC. Functional assays using a collection of human primary iNKT cell lines demonstrated that the gut microbiota of female patients functionally impairs iNKT cell anti-tumor functions interfering with the granzyme-perforin cytotoxic pathway. Our results highlight a sex-dependent functional relationship between the gut microbiome, estrogen metabolism, and the decline of cytotoxic T cell responses, contributing to the sexual dimorphism observed in CRC patients with relevant implications for precision medicine and the design of targeted therapeutic approaches addressing sex bias in cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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85. Diagnosis of cardiac amyloid transthyretin (ATTR) amyloidosis by early (soft tissue) phase [99mTc]Tc-DPD whole body scan: comparison with late (bone) phase imaging
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Minutoli, Fabio, Russo, Massimo, Di Bella, Gianluca, Laudicella, Riccardo, Spataro, Alessandro, Vento, Antonio, Comis, Alessio, Gentile, Luca, Mazzeo, Anna, Vita, Giuseppe, and Baldari, Sergio
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- 2022
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86. [177Lu]Lu-DOTA-TATE versus standard of care in adult patients with gastro-enteropancreatic neuroendocrine tumours (GEP-NETs): a cost-consequence analysis from an Italian hospital perspective
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Spada, Francesca, Campana, Davide, Lamberti, Giuseppe, Laudicella, Riccardo, Dellamano, Renato, Dellamano, Luca, Leeuwenkamp, Oscar, and Baldari, Sergio
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- 2022
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87. Prognostic factors in children and adolescents with differentiated thyroid carcinoma treated with total thyroidectomy and RAI: a real-life multicentric study
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Cistaro, Angelina, Quartuccio, Natale, Garganese, Maria Carmen, Villani, Maria Felicia, Altini, Claudio, Pizzoferro, Milena, Piccardo, Arnoldo, Cabria, Manlio, Massollo, Michela, Maghnie, Mohamad, Campennì, Alfredo, Siracusa, Massimiliano, Baldari, Sergio, Panareo, Stefano, Urso, Luca, Bartolomei, Mirco, De Palma, Diego, Grossi, Armando, Mazzoletti, Angelica, Dondi, Francesco, Bertagna, Francesco, Giubbini, Raffaele, and Albano, Domenico
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- 2022
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88. Editorial: Mechanisms of lymphocyte mediated cytotoxicity in health and disease
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Cosima T. Baldari, Salvatore Valitutti, and Michael L. Dustin
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CTL ,NK ,cytotoxicity ,immune evasion ,cancer ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2023
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89. Influence of training status on cardiac and vascular functioning in young recreational and competitive male rowers
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Lavinia Falcioni, Maria Chiara Gallotta, Carlo Baldari, Ludovica Cardinali, Matteo Campanella, Dafne Ferrari, Laura Guidetti, and Marco Meucci
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cardiovascular health ,non-invasive measurements ,rowing training ,young athletes ,rower athletes ,Pediatrics ,RJ1-570 - Abstract
IntroductionThe aim of the study was to investigate the influence of training status on cardiovascular function in young male recreational and competitive rowers.MethodsEjection duration in percentage to the heart rate period (ED%), subendocardial viability ratio (SEVR), augmentation index at 75 bpm (AIx75) and carotid to femoral pulse wave velocity (cf-PWV) of competitive rowers (CR) (age 17.6 ± 4.1 years), recreational rowers (RR) (age 16.7 ± 2.70 years) and athletes practicing other recreational sports (ORS) (age 15.3 ± 1.4 years) were assessed.ResultsED% was lower in CR compared to ORS (31.9 ± 3.9% vs. 38.4 ± 4.8%; p = 0.026) and cf-PWV was higher in CR compared to ORS (5.5 ± 1.0 m/s vs. 4.7 ± 0.5 m/s; p = 0.032). SEVR was higher in CR compared to RR and ORS (165.8 ± 33.7% vs. 127.4 ± 30.4% and 128.3 ± 27.8%; p = 0.022) and AIx75 was lower in CR compared to RR and ORS (−15.7 ± 8.6% vs. 1.2 ± 9.9% and 1.5 ± 9.1; p = 0.001).DiscussionHealthy, young competitive male rowers reported higher myocardial performance and better cardiovascular health than recreational athletes. Interpretations of cf-PWV in competitive rowers should be performed alongside other cardiovascular indicators.
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- 2023
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90. Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes
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Chang, Hsin-Fang, Schirra, Claudia, Ninov, Momchil, Hahn, Ulrike, Ravichandran, Keerthana, Krause, Elmar, Becherer, Ute, Bálint, Štefan, Harkiolaki, Maria, Urlaub, Henning, Valitutti, Salvatore, Baldari, Cosima T., Dustin, Michael L., Jahn, Reinhard, and Rettig, Jens
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- 2022
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91. Molecular Imaging of Vulnerable Plaque
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Laudicella, Riccardo, Christel, Kamani, Burger, Irene A., Baldari, Sergio, Alongi, Pierpaolo, and Caobelli, Federico, editor
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- 2021
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92. Defining the Burden of Emergency General Surgery in the Elderly Today
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Cassinotti, Elisa, Boni, Luigi, Baldari, Ludovica, Agresta, Ferdinando, editor, Podda, Mauro, editor, Campanile, Fabio Cesare, editor, Bergamini, Carlo, editor, and Anania, Gabriele, editor
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- 2021
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93. Soldierly virtue : an argument for the restructuring of Western military ethics to align with Aristotelian virtue ethics
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Baldari, John Doyle and Dow, Jamie
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174 - Abstract
Because wars are fought by human beings and not merely machines, a strong virtue ethic is an essential prerequisite for those engaged in combat. From a philosophical perspective, war has historically been seen as separate and outside of the commonly accepted forms of morality. Yet there remains a general, though not well-thought out, sense that those human beings who fight wars should act ethically. Since warfighters are often called upon to contemplate and complete tasks during war that are not normally required of non-warfighters (civilians), and it is believed these warfighters should act ethically, it becomes necessary to ask: What does soldierly virtue look like? In order to answer this question, I will examine essential elements of moral responsibility and military authority. Once complete, I will propose an Aristotelian-based virtue ethics system, one that is equally valuable to warfighter and civilian. To do this, I will examine the conversation in academia regarding virtue ethics and the foundations of virtue. I will provide both a cursory and deep reading of elements of Aristotle's conception of virtue, but ultimately I will provide a slightly more rigorous reading and reinterpretation of an Aristotelian-based virtue ethic, with a definitive final recommendation for this interpretation being best for everyone, in war or walking down the street. Upon completing a study of this work, one will walk away with a next-generation interpretation of Aristotelian-based Virtue Ethics that denies eudaimonia as the central principle, relying instead on phronesis as its central theme. Phronesis, when properly developed in the warfighter will lead to moral responsibility, better decision-making, and a seamless re-integration into civilian life once has returned from the horrors of war.
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- 2018
94. A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly
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Capitani, Nagaja, Onnis, Anna, Finetti, Francesca, Cassioli, Chiara, Plebani, Alessandro, Brunetti, Jlenia, Troilo, Arianna, D’Elios, Sofia, Baronio, Manuela, Gazzurelli, Luisa, Della Bella, Chiara, Billadeau, Daniel D., D’Elios, Mario Milco, Lougaris, Vassilios, and Baldari, Cosima T.
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- 2022
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95. Simplified patient-specific renal dosimetry in 177Lu therapy: a proof of concept
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Ligonnet, Thomas, Pistone, Daniele, Auditore, Lucrezia, Italiano, Antonio, Amato, Ernesto, Campennì, Alfredo, Schaefer, Niklaus, Boughdad, Sarah, Baldari, Sergio, and Gnesin, Silvano
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- 2021
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96. Nutritional and physical activity issues in frailty syndrome during the COVID-19 pandemic
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Maria Chiara Massari, Viviana Maria Bimonte, Lavinia Falcioni, Antimo Moretti, Carlo Baldari, Giovanni Iolascon, and Silvia Migliaccio
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
‘Frailty’ has been described as ‘a state of increased vulnerability of the individual caused by an impairment of homeostasis as a result of endogenous or exogenous stress’. Frail individuals are depicted by a dramatic change in health status following an apparently minor insult and a higher risk of adverse health-related outcomes such as osteoporosis and sarcopenia, falls and disability, and fragility fractures. Frailty is a condition of increasing importance due to the global ageing of the population during the last decades. Central to the pathophysiology of frailty is a mechanism that is partially independent of ageing, but most likely evolves with ageing: the cumulative level of molecular and cellular damage in every subject. Furthermore, an uncorrected nutrition and a sedentary behaviour play a pivotal role in worsening the syndrome. In January 2020, a cluster of a genus of the family Coronaviridae was isolated as the pathogen of the new coronavirus disease (COVID-19). Since then, this infection has spread worldwide causing one of the most dramatic pandemics of the modern era, with more than 500 million confirmed cases all over the world. The clinical spectrum of SARS-CoV-2 severity ranges from asymptomatic conditions to mild symptoms, such as fever, cough, ageusia, anosmia and asthenia, up to most severe conditions, such as acute respiratory distress syndrome (ARDS) and multi-organ failure leading to death. Primary evidence revealed that the elderly frail subjects were more susceptible to the disease in its most intense form and were at greater risk of developing severe COVID-19. Factors contributing to the severity of COVID-19, and the higher mortality rate, are a poor immune system activity and long-standing inflammatory status of the frail subjects compared with the general population. Further recent research also suggested a potential role of sedentary behaviour, metabolic chronic disorders linked to it and uncorrected nutritional status. Thus, the aim of this review was to evaluate the different studies and evidence related to COVID-19 pandemic, both nutritional status and physical activity, and, also, to provide further information on the correct nutritional approach in this peculiar pathological condition.
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- 2023
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97. Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome
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Claudia Grossi, Nagaja Capitani, Marisa Benagiano, Cosima Tatiana Baldari, Chiara Della Bella, Paolo Macor, Francesco Tedesco, Maria Orietta Borghi, Norma Maugeri, Mario Milco D’Elios, and Pier Luigi Meroni
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β2GPI ,neutrophils ,T cells ,NETs ,APS ,aPL ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent vascular thrombosis and miscarriages in the absence of known causes. Antibodies against phospholipid-binding proteins (aPL) are pathogenic players in both clotting and pregnancy APS manifestations. There is sound evidence that antibodies specific for beta2 glycoprotein I (β2GPI) trigger thrombotic and pregnancy complications by interacting with the molecule on the membranes of different cell types of the coagulation cascade, and in placenta tissues. In addition to the humoral response against β2GPI, both peripheral and tissue CD4+ β2GPI-specific T cells have been reported in primary APS as well as in systemic lupus erythematosus (SLE)-associated APS. While adaptive immunity plays a clear role in APS, it is still debated whether innate immunity is involved as well. Acute systemic inflammation does not seem to be present in the syndrome, however, there is sound evidence that complement activation is crucial in animal models and can be found also in patients. Furthermore, neutrophil extracellular traps (NETs) have been documented in arterial and venous thrombi with different etiology, including clots in APS models. Keeping in mind that β2GPI is a pleiotropic glycoprotein, acting as scavenger molecule for infectious agents and apoptotic/damaged body constituents and that self-molecules externalized through NETs formation may become immunogenic autoantigens, we demonstrated β2GPI on NETs, and its ability to stimulate CD4+β2GPI-specific T cells. The aim of this review is to elucidate the role of β2GPI in the cross-talk between the innate and adaptive immunity in APS.
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- 2023
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98. The prognostic power of 18F-FDG PET/CT extends to estimating systemic treatment response duration in metastatic castration-resistant prostate cancer (mCRPC) patients
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Bauckneht, Matteo, Bertagna, Francesco, Donegani, Maria Isabella, Durmo, Rexhep, Miceli, Alberto, De Biasi, Vincenzo, Laudicella, Riccardo, Fornarini, Giuseppe, Berruti, Alfredo, Baldari, Sergio, Versari, Annibale, Giubbini, Raffaele, Sambuceti, Gianmario, Morbelli, Silvia, and Albano, Domenico
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- 2021
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99. Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer
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Gebbia, Vittorio, Guarini, Aurelia, Piazza, Dario, Bertani, Alessandro, Spada, Massimiliano, Verderame, Francesco, Sergi, Concetta, Potenza, Enrico, Fazio, Ivan, Blasi, Livio, La Sala, Alba, Mortillaro, Gianluca, Roz, Elena, Marchese, Roberto, Chiarenza, Maurizio, Soto-Parra, Hector, Valerio, Maria Rosaria, Agneta, Giuseppe, Amato, Carmela, Lipari, Helga, Baldari, Sergio, Ferraù, Francesco, Di Grazia, Alfio, Mancuso, Gianfranco, Rizzo, Sergio, and Firenze, Alberto
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- 2021
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100. The role of PET radiomic features in prostate cancer: a systematic review
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Quartuccio, Natale, Marrale, Maurizio, Laudicella, Riccardo, Alongi, Pierpaolo, Siracusa, Massimiliano, Sturiale, Letterio, Arnone, Giuseppe, Cutaia, Giuseppe, Salvaggio, Giuseppe, Midiri, Massimo, Baldari, Sergio, and Arnone, Gaspare
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- 2021
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