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58. Should kidney allografts from old donors be allocated only to old recipients?

Author

Süsal, C., Kumru, G., Döhler, B., Morath, C., Baas, M.C., Lutz, J., Unterrainer, C., Arns, W., Aubert, O., Bara, C., Beiras-Fernandez, A., Böhmig, G.A., Bösmüller, C., Diekmann, F., Dutkowski, P., Hauser, I., Legendre, C., Lozanovski, V.J., Mehrabi, A., Melk, A., Minor, T., Mueller, T.F., Pisarski, P., Rostaing, L., Schemmer, P., Schneeberger, S., Schwenger, V., Sommerer, C., Tönshoff, B., Viebahn, R., Viklicky, O., Weimer, R., Weiss, K.H., Zeier, M., Živčić-Ćosić, S., Heemann, U., Süsal, C., Kumru, G., Döhler, B., Morath, C., Baas, M.C., Lutz, J., Unterrainer, C., Arns, W., Aubert, O., Bara, C., Beiras-Fernandez, A., Böhmig, G.A., Bösmüller, C., Diekmann, F., Dutkowski, P., Hauser, I., Legendre, C., Lozanovski, V.J., Mehrabi, A., Melk, A., Minor, T., Mueller, T.F., Pisarski, P., Rostaing, L., Schemmer, P., Schneeberger, S., Schwenger, V., Sommerer, C., Tönshoff, B., Viebahn, R., Viklicky, O., Weimer, R., Weiss, K.H., Zeier, M., Živčić-Ćosić, S., and Heemann, U.

Abstract

Item does not contain fulltext, In several deceased donor kidney allocation systems, organs from elderly donors are allocated primarily to elderly recipients. The Eurotransplant Senior Program (ESP) was implemented in 1999, and since then, especially in Europe, the use of organs from elderly donors has steadily increased. The proportion of ≥60-year-old donors reported to the Collaborative Transplant Study (CTS) by European centers has doubled, from 21% in 2000-2001 to 42% in 2016-2017. Therefore, in the era of organ shortage it is a matter of debate whether kidney organs from elderly donors should only be allocated to elderly recipients or whether <65-year-old recipients can also benefit from these generally as "marginal" categorized organs. To discuss this issue, a European Consensus Meeting was organized by the CTS on April 12, 2018, in Heidelberg, in which 36 experts participated. Based on available evidence, it was unanimously concluded that kidney organs from 65- to 74-year-old donors can also be allocated to 55- to 64-year-old recipients, especially if these organs are from donors with no history of hypertension, no increased creatinine, no cerebrovascular death, and no other reasons for defining a marginal donor, such as diabetes or cancer.

Published
2020

59. Self-medication with antibiotics in Europe: O53

Author

Grigoryan, L., Haaijer-Ruskamp, F. M., Monnet, D., Mechtler, R., Andrasevic, A. Tambic, Alkerwi, A., Scicluna, E. A., Lundborg, C. Stalsby, Birkin, J., Di Matteo, A., Cunney, R., Edelstein, H., Valinteliene, R., Deschepper, R., Andrajati, R., Grzesiowski, P., Campos, J., Bara, C., Tesar, T., and Cizman, M.

Published
2005

63. Efficacité du méthotrexate en adjonction d’un traitement par anti-histaminiques H1 dans le traitement de l’urticaire chronique spontanée sévère réfractaire aux anti-H1 seuls : essai de phase III, randomisé, en double aveugle (NCT01960283)

Author

Leducq, S., primary, Samimi, M., additional, Bernier, C., additional, Soria, A., additional, Amsler, E., additional, Staumont-Sallé, D., additional, Gabison, G., additional, Chosidow, O., additional, Bénéton, N., additional, Bara, C., additional, Grange-Prunier, A., additional, Wierzbicka-Hainaut, E., additional, Brenaut, E., additional, Droitcourt, C., additional, Rayson-Peyron, N., additional, Bourgoin, H., additional, Cornillier, H., additional, Machet, L., additional, Giraudeau, B., additional, Caille, A., additional, and Maruani, A., additional

Published
2019
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64. Improvement of Left Ventricular Ejection Fraction by a Novel Electrical Microcurrent Therapy in a Sheep Model of Chronic Heart Failure

Author

Napp, L., primary, Baum, C., additional, Dogan, G., additional, Hanke, J.S., additional, Meyer, T., additional, Goettel, P., additional, Brandes, K., additional, Sarikouch, S., additional, Bara, C., additional, Bauersachs, J., additional, Haverich, A., additional, Mueller, J., additional, and Schmitto, J.D., additional

Published
2019
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65. Cardiac Transplantation in Higher Risk Patients: Is Ex Vivo Heart Perfusion a Safe Preservation Technique? A Two Center Experience

Author

Rojas, S.V., primary, Ius, F., additional, Schibilsky, D., additional, Kaufeld, T., additional, Sommer, W., additional, Benk, C., additional, Goecke, T., additional, Siemeni, T., additional, Poyanmehr, R., additional, Rümke, S., additional, Mogaldea, A., additional, Bobylev, D., additional, Salman, J., additional, Avsar, M., additional, Tudorache, I., additional, Bara, C., additional, Beyersdorf, F., additional, Haverich, A., additional, Siepe, M., additional, and Warnecke, G., additional

Published
2019
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66. Cardiac Transplantation across Preformed HLA-Antibody Barriers: Results of a Peritransplant Desensitization Protocol

Author

Ius, F., primary, Rojas, S.V., additional, Kaufeld, T., additional, Sommer, W., additional, Bara, C., additional, Salman, J., additional, Siemeni, T., additional, Poyanmehr, R., additional, Bobylev, D., additional, Avsar, M., additional, Tudorache, I., additional, Falk, C.S., additional, Haverich, A., additional, and Warnecke, G., additional

Published
2019
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67. Effects of Ex Vivo Perfusion and Il-6 Receptor Blockade on Ischemia Reperfusion Injury in Cardiac Transplantation

Author

Falk, C., primary, Ius, F., additional, Rojas-Hernandez, S.V., additional, Wiegmann, B., additional, Wandrer, F., additional, Kaufeld, T., additional, Sommer, W., additional, Bara, C., additional, Salman, J., additional, Siemeni, T., additional, Poyanmehr, R., additional, Bobylev, D., additional, Tudorache, I., additional, Avsar, M., additional, Haverich, A., additional, and Warnecke, G., additional

Published
2019
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69. Ex Vivo Heart Perfusion for Higher Risk Cardiac Transplantations: A Retrospective Analysis from Two German Centers

Author

Rojas, S., additional, Ius, F., additional, Schibilsky, D., additional, Kaufeld, T., additional, Benk, C., additional, Goecke, T., additional, Avsar, M., additional, Poyanmehr, R., additional, Rümke, S., additional, Mogaldea, A., additional, Bobylev, D., additional, Salman, J., additional, Siemeni, T., additional, Bara, C., additional, Beyersdorf, F., additional, Haverich, A., additional, Siepe, M., additional, and Warnecke, G., additional

Published
2019
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71. Prognostic Value of the Nutritional Risk Index in Candidates for Continuous Flow Left Ventricular Assist Device Therapy

Author

Uribarri, A., primary, Rojas, S.V., additional, Hanke, J.S., additional, Dogan, G., additional, Siemeni, T., additional, Kaufeld, T., additional, Goecke, T., additional, Rojas-Hernandez, S., additional, Warnecke, G., additional, Bara, C., additional, Avsar, M., additional, Schmitto, J.D., additional, and Haverich, A., additional

Published
2018
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72. Specificity of DNA ADP-Ribosylation Reversal by NADARs

Author

Bara Cihlova, Yang Lu, Andreja Mikoč, Marion Schuller, and Ivan Ahel

Subjects
ADP-ribosylation, toxin–antitoxin system, DNA modification, PARP, DNA damage, YbiA, Medicine
Abstract

Recent discoveries establish DNA and RNA as bona fide substrates for ADP-ribosylation. NADAR (“NAD- and ADP-ribose”-associated) enzymes reverse guanine ADP-ribosylation and serve as antitoxins in the DarT-NADAR operon. Although NADARs are widespread across prokaryotes, eukaryotes, and viruses, their specificity and broader physiological roles remain poorly understood. Using phylogenetic and biochemical analyses, we further explore de-ADP-ribosylation activity and antitoxin functions of NADAR domains. We demonstrate that different subfamilies of NADAR proteins from representative E. coli strains and an E. coli-infecting phage retain biochemical activity while displaying specificity in providing protection from toxic guanine ADP-ribosylation in cells. Furthermore, we identify a myxobacterial enzyme within the YbiA subfamily that functions as an antitoxin for its associated DarT-unrelated ART toxin, which we termed YarT, thus presenting a hitherto uncharacterised ART-YbiA toxin–antitoxin pair. Our studies contribute to the burgeoning field of DNA ADP-ribosylation, supporting its physiological relevance within and beyond bacterial toxin–antitoxin systems. Notably, the specificity and confinement of NADARs to non-mammals infer their potential as highly specific targets for antimicrobial drugs with minimal off-target effects.

Published
2024
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79. Pemphigoïdes bulleuses associées aux gliptines : mythe ou réalité ?

Author

Plaquevent, M., primary, Tetart, F., additional, Fardet, L., additional, Oro, S., additional, Bernard, P., additional, Roussel, A., additional, Avenel-Audran, M., additional, Chaby, G., additional, D’incan, M., additional, Souteyrand, P., additional, Duvert-Lehembre, S., additional, Picard-Dahan, C., additional, Jeudy, G., additional, Labeille, B., additional, Morice, C., additional, Richard, M.-A., additional, Bourgault Villada, I., additional, Litrowski, N., additional, Bara, C., additional, Mahe, E., additional, Prost, C., additional, Alexandre, M., additional, Quereux, G., additional, Soria, A., additional, Thomas-Beaulieu, D., additional, Pauwels, C., additional, and Joly, P., additional

Published
2017
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81. Telemonitoring in LVAD-Patients: Acceptance and Need

Author

Feldmann, C., primary, Deniz, E., additional, Schmidt, T., additional, Hoffmann, J., additional, Hanke, J.S., additional, Rojas, S.V., additional, Dogan, G., additional, Berliner, D., additional, Bara, C., additional, Warnecke, G., additional, Haverich, A., additional, Schmitto, J.D., additional, and Reiss, N., additional

Published
2017
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83. Scuola Lavoro Famiglia Università. Per un sistema formativo alleato e competente

Author

Malavasi Pierluigi (ORCID:0000-0001-8178-967X), Simeone Domenico (ORCID:0000-0002-4718-1190), M. Amadini, E. Bara, C. Bellotti, C. Birbes, L. Cadei, P. Malavasi, S. Mazzoli, M. P. Mostarda, S. Sandrini, D. Simeone, A. Vischi, E. Zane, P. Zini, Malavasi, Pierluigi, Simeone, Domenico, Malavasi Pierluigi (ORCID:0000-0001-8178-967X), Simeone Domenico (ORCID:0000-0002-4718-1190), M. Amadini, E. Bara, C. Bellotti, C. Birbes, L. Cadei, P. Malavasi, S. Mazzoli, M. P. Mostarda, S. Sandrini, D. Simeone, A. Vischi, E. Zane, P. Zini, Malavasi, Pierluigi, and Simeone, Domenico

Abstract

In uno scenario contrassegnato dall’accelerazione dei cambiamenti socioeconomici e dalla complessità delle dinamiche geopolitiche, la sfida della collaborazione tra scuola e lavoro permane centrata sulla formazione delle persone. Chiama in causa famiglie e università, la coscienza e l’intenzionalità dell’impegno profuso nelle relazioni educative. Gli autori dei saggi indicano le potenzialità di un’alleanza sistemica e competente tra istituzioni formative, professioni e realtà associative. Senza celare ambiguità e difficoltà nei percorsi di alternanza scuola lavoro, il volume accredita l’ipotesi che per favorirne il successo sia essenziale la progettazione e il coordinamento pedagogico. Nel curricolo del secondo ciclo di istruzione, includere moduli in cui gli allievi svolgono esperienze in contesti lavorativi può dare vita ad un inedito processo di cross fertilisation, tra saperi e organizzazioni, generi e generazioni. Scuola lavoro università famiglia. Per un sistema formativo alleato e competente. Nell’intelligenza delle nostre mani, lo sviluppo umano come libertà

Published
2017

85. The Impact of Telemonitoring in Patients with Ventricular Assist Device

Author

Deniz, E., additional, Feldmann, C., additional, Schmidt, T., additional, Hoffmann, J.D., additional, Hanke, J., additional, Rojas-Hernandez, S.V., additional, Dogan, G., additional, Berliner, D., additional, Bara, C., additional, Warnecke, G., additional, Haverich, A., additional, Schmitto, J.D., additional, and Reiss, N., additional

Published
2017
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86. First Experience with the HeartAssist5® Left Ventricular Assist Device

Author

Deniz, E., additional, Hanke, J.S., additional, Schwick, F., additional, Rojas-Hernandez, S.V., additional, Dogan, G., additional, Feldmann, C., additional, Molitoris, U., additional, Fegbeutel, C., additional, Bara, C., additional, Shrestha, M., additional, Haverich, A., additional, and Schmitto, J.D., additional

Published
2017
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89. Heart-Lung Transplantation for Congenital Heart Disease: A 25 Years Single Center Experience

Author

Bobylev, D., primary, Salman, J., additional, Sommer, W., additional, Tudorache, I., additional, Ius, F., additional, Siemeni, T., additional, Kuehn, C., additional, Avsar, M., additional, Bara, C., additional, Horke, A., additional, Boethig, D., additional, Schwerk, N., additional, Gottlieb, J., additional, Haverich, A., additional, and Warnecke, G., additional

Published
2016
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95. Chronische Abstoßung

Author

Suhling, H., primary, Gottlieb, J., additional, Bara, C., additional, Taubert, R., additional, Jäckel, E., additional, Schiffer, M., additional, and Bräsen, J.H., additional

Published
2016
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96. Tuberculose active et psoriasis traité par anti-TNF alpha : étude nationale

Author

Guinard, E., primary, Bulai Livideanu, C., additional, Barthélémy, H., additional, Viguier, M., additional, Reguiai, Z., additional, Richard, M.-A., additional, Jullien, D., additional, Martinelli, J., additional, Beneton, N., additional, Bara, C., additional, Vabres, P., additional, Grandvuillemin, A., additional, Marguery, M.C., additional, Amelot, F., additional, Ofaiche, J., additional, Konstantinou, M.-P., additional, Bagheri, H., additional, and Paul, C., additional

Published
2015
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98. Perioperative ECMO Use in Lung Transplantation for Severe Pulmonary Hypertension

Author

Tudorache, I., primary, Sommer, W., additional, Ius, F., additional, Kühn, C., additional, Wiesner, O., additional, Hadem, J., additional, Fühner, T., additional, Avsar, M., additional, Schwerk, N., additional, Böthig, D., additional, Gottlieb, J., additional, Welte, T., additional, Bara, C., additional, Haverich, A., additional, Höper, M., additional, and Warnecke, G., additional

Published
2015
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99. A Multi-Center, Randomized, Open-Label, Parallel Group Phase IV Trial Investigating the Outcome on Renal Function, Efficacy and Safety of CNI-Reduction or Elimination With Everolimus in De Novo Heart Transplant: Recipients: The MANDELA Study Design

Author

Deuse, T., primary, Bara, C., additional, Barten, M., additional, Hirt, S., additional, Doesch, A., additional, Knosalla, C., additional, Grinninger, C., additional, Stypmann, J., additional, Porstner, M., additional, Wimmer, P., additional, and Schulz, U., additional

Published
2015
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