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51. Challenges and opportunities in the recovery of gold from electronic waste

Author

Kamalesh K. Singh, Jason B. Love, Mudila Dhanunjaya Rao, and Carole A. Morrison

Subjects
Waste management, General Chemical Engineering, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Electronic waste, 0104 chemical sciences, Sustainability, Hardware_INTEGRATEDCIRCUITS, Environmental science, Electronics, 0210 nano-technology
Abstract

Rapid global technological development has led to the rising production of electronic waste that presents both challenges and opportunities in its recycling. In this review, we highlight the value of metal resources in the printed circuit boards (PCBs) commonly found in end-of-life electronics, the differences between primary (ore) mining applications and secondary ('urban') mining, and the variety of metallurgical separations, in particular those that have the potential to selectively and sustainably recover gold from waste PCBs.

Published
2020

52. Selective recovery of nickel from obsolete mobile phone PCBs

Author

Mudila Dhanunjaya Rao, Kamalesh K. Singh, Carole A. Morrison, and Jason B. Love

Subjects
Solvent extraction, Nickel, ACORGA M5640, Materials Chemistry, Metals and Alloys, Cementation, Industrial and Manufacturing Engineering, WPCBs
Abstract

In the present investigation, the selective recovery of nickel from a leach solution of delaminated metal clads from obsolete mobile phone PCBs using the industrial reagent ACORGA M5640 has been studied. As a first step, copper is selectively separated from the mixed metal leach liquor by solvent extraction at pH 2, to leave a nickel-rich raffinate solution. A second stage solvent extraction process conducted at pH 8 then permits recovery of the nickel. Small quantities of zinc and cadmium are also co-extracted. In this study, the conditions for most suitable nickel extraction and stripping have been explored. Results indicate that quantitative extraction of nickel (99.7%) can be achieved using a 1:5 organic (10 vol% extractant in kerosene) to aqueous (pH 8) phase ratio in 60 min. The nickel in the organic phase is readily stripped from the extractant, with more than 95% recovered, along with low levels of zinc (1.7 mg/L) and cadmium (0.6 mg/L), following a 0.5 M hydrochloric acid or 1 M nitric acid strip step. Cyclic usage of the extractant organic layer revealed that its effectiveness to extraction has remained equivalent to the first cycle. Finally, the separation of trace elements such as lead, tin and cadmium from the raffinate of stage 2 solvent extraction is also studied by cementation with zinc powder. The study reveals that the removal of these elements and the generation of pure zinc solution can be obtained by adding 300% excess zinc powder (74 μm) at 50 °C with 500 rpm stirring speed in 60 min. The separation of copper in stage 1, nickel from copper-free aqueous solution in stage 2 and other minor elements from the raffinate of stage 2 solvent extraction ensures the proposed process is sustainable and avoids complexity in the sequential metal recovery processes.

Published
2022

54. Monitoring strategies for clinical intervention studies

Author

Sharon B. Love, Christiane Pauli-Magnus, Patricia Arnaiz Jimenez, Marie Mi Bonde, Nicole Bruni, Matthias Briel, Pascal Benkert, Matthew R. Sydes, Hannah Ewald, and Katharina Klatte

Subjects
medicine.medical_specialty, business.industry, Medicine, Humans, Pilot Projects, Pharmacology (medical), Prospective Studies, business, Intensive care medicine, Intervention studies
Abstract

BACKGROUND: Trial monitoring is an important component of good clinical practice to ensure the safety and rights of study participants, confidentiality of personal information, and quality of data. However, the effectiveness of various existing monitoring approaches is unclear. Information to guide the choice of monitoring methods in clinical intervention studies may help trialists, support units, and monitors to effectively adjust their approaches to current knowledge and evidence. OBJECTIVES: To evaluate the advantages and disadvantages of different monitoring strategies (including risk‐based strategies and others) for clinical intervention studies examined in prospective comparative studies of monitoring interventions. SEARCH METHODS: We systematically searched CENTRAL, PubMed, and Embase via Elsevier for relevant published literature up to March 2021. We searched the online 'Studies within A Trial' (SWAT) repository, grey literature, and trial registries for ongoing or unpublished studies. SELECTION CRITERIA: We included randomized or non‐randomized prospective, empirical evaluation studies of different monitoring strategies in one or more clinical intervention studies. We applied no restrictions for language or date of publication. DATA COLLECTION AND ANALYSIS: We extracted data on the evaluated monitoring methods, countries involved, study population, study setting, randomization method, and numbers and proportions in each intervention group. Our primary outcome was critical and major monitoring findings in prospective intervention studies. Monitoring findings were classified according to different error domains (e.g. major eligibility violations) and the primary outcome measure was a composite of these domains. Secondary outcomes were individual error domains, participant recruitment and follow‐up, and resource use. If we identified more than one study for a comparison and outcome definitions were similar across identified studies, we quantitatively summarized effects in a meta‐analysis using a random‐effects model. Otherwise, we qualitatively summarized the results of eligible studies stratified by different comparisons of monitoring strategies. We used the GRADE approach to assess the certainty of the evidence for different groups of comparisons. MAIN RESULTS: We identified eight eligible studies, which we grouped into five comparisons. 1. Risk‐based versus extensive on‐site monitoring: based on two large studies, we found moderate certainty of evidence for the combined primary outcome of major or critical findings that risk‐based monitoring is not inferior to extensive on‐site monitoring. Although the risk ratio was close to 'no difference' (1.03 with a 95% confidence interval [CI] of 0.81 to 1.33, below 1.0 in favor of the risk‐based strategy), the high imprecision in one study and the small number of eligible studies resulted in a wide CI of the summary estimate. Low certainty of evidence suggested that monitoring strategies with extensive on‐site monitoring were associated with considerably higher resource use and costs (up to a factor of 3.4). Data on recruitment or retention of trial participants were not available. 2. Central monitoring with triggered on‐site visits versus regular on‐site visits: combining the results of two eligible studies yielded low certainty of evidence with a risk ratio of 1.83 (95% CI 0.51 to 6.55) in favor of triggered monitoring intervention. Data on recruitment, retention, and resource use were not available. 3. Central statistical monitoring and local monitoring performed by site staff with annual on‐site visits versus central statistical monitoring and local monitoring only: based on one study, there was moderate certainty of evidence that a small number of major and critical findings were missed with the central monitoring approach without on‐site visits: 3.8% of participants in the group without on‐site visits and 6.4% in the group with on‐site visits had a major or critical monitoring finding (odds ratio 1.7, 95% CI 1.1 to 2.7; P = 0.03). The absolute number of monitoring findings was very low, probably because defined major and critical findings were very study specific and central monitoring was present in both intervention groups. Very low certainty of evidence did not suggest a relevant effect on participant retention, and very low‐quality evidence indicated an extra cost for on‐site visits of USD 2,035,392. There were no data on recruitment. 4. Traditional 100% source data verification (SDV) versus targeted or remote SDV: the two studies assessing targeted and remote SDV reported findings only related to source documents. Compared to the final database obtained using the full SDV monitoring process, only a small proportion of remaining errors on overall data were identified using the targeted SDV process in the MONITORING study (absolute difference 1.47%, 95% CI 1.41% to 1.53%). Targeted SDV was effective in the verification of source documents but increased the workload on data management. The other included study was a pilot study which compared traditional on‐site SDV versus remote SDV and found little difference in monitoring findings and the ability to locate data values despite marked differences in remote access in two clinical trial networks. There were no data on recruitment or retention. 5. Systematic on‐site initiation visit versus on‐site initiation visit upon request: very low certainty of evidence suggested no difference in retention and recruitment between the two approaches. There were no data on critical and major findings or on resource use. AUTHORS' CONCLUSIONS: The evidence base is limited in terms of quantity and quality. Ideally, for each of the five identified comparisons, more prospective, comparative monitoring studies nested in clinical trials and measuring effects on all outcomes specified in this review are necessary to draw more reliable conclusions. However, the results suggesting risk‐based, targeted, and mainly central monitoring as an efficient strategy are promising. The development of reliable triggers for on‐site visits is ongoing; different triggers might be used in different settings. More evidence on risk indicators that identify sites with problems or the prognostic value of triggers is needed to further optimize central monitoring strategies. In particular, approaches with an initial assessment of trial‐specific risks that need to be closely monitored centrally during trial conduct with triggered on‐site visits should be evaluated in future research.

Published
2021

55. Understanding the Recovery of Rare-Earth Elements by Ammonium Salts

Author

Jamie P. Hunter, Sara Dolezalova, Bryne T. Ngwenya, Carole A. Morrison, and Jason B. Love

Subjects
ionic liquids, extraction, rare-earths, mass-spectrometry, computational modelling, Mining engineering. Metallurgy, TN1-997
Abstract

While the recovery of rare earth elements (REEs) from aqueous solution by ionic liquids (ILs) has been well documented, the metal compounds that are formed in the organic phase remain poorly characterized. Using spectroscopic, analytical, and computational techniques, we provide detailed chemical analysis of the compounds formed in the organic phase during the solvent extraction of REEs by [(n-octyl)3NMe][NO3] (IL). These experiments show that REE recovery using IL is a rapid process and that IL is highly durable. Karl-Fischer measurements signify that the mode of action is unlikely to be micellar, while ions of the general formula REE(NO3)4(IL)2− are seen by negative ion electrospray ionization mass spectrometry. Additionally, variable temperature 139La nuclear magnetic resonance spectroscopy suggests the presence of multiple, low symmetry nitrato species. Classical molecular dynamics simulations show aggregation of multiple ILs around a microhydrated La3+ cation with four nitrates completing the inner coordination sphere. This increased understanding is now being exploited to develop stronger and more selective, functionalized ILs for REE recovery.

Published
2018
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56. Assessment of the Development of Social and Learning Networks in Construction Management Courses Using Social Network Analysis

Author

Mehmet E. Ozbek, Hannah B. Love, and Jennifer E. Cross

Subjects
Construction management, Community based research, Knowledge management, ComputingMilieux_THECOMPUTINGPROFESSION, business.industry, Computer science, 05 social sciences, 0211 other engineering and technologies, Service-learning, 050301 education, 02 engineering and technology, Building and Construction, Education, Variety (cybernetics), 021105 building & construction, ComputingMilieux_COMPUTERSANDEDUCATION, Technical skills, business, 0503 education, Social network analysis
Abstract

Preparing Construction Management (CM) students for their professional lives must include not only training on technical skills, but also a variety of personal interaction skills, from working with...

Published
2019

57. Canadian Surgery Forum 201901. The future of general surgery training: a Canadian resident nationwide Delphi consensus statement02. Traumatized: Can mindfulness lead to improved mental health outcomes after multisystem trauma?03. Operating room availability for general surgery in 2007 versus 2017 at a regional hospital in BC04. Perceptions and barriers to Gastrografin protocol implementation05. Resident opinions and educational experience of a mixed night-float system for general surgery resident call06. A scoping review of best management for hepato-pancreatobiliary trauma07. Simultaneous versus staged resection for synchronous colorectal liver metastases: a population-based cohort study08. Weight loss following hepatopancreatobiliary surgery. How much is too much?09. Uptake and patient outcomes of laparoscopic liver resection for colon cancer liver metastases: a population-based analysis10. Simultaneous resection of colorectal cancer with synchronous liver metastases: a survey-based analysis11. When is it safe to start VTE prophylaxis after blunt solid organ injury? A prospective study from a level I trauma centre12. Undertriaged trauma patients: Who are we missing?13. Trauma team activation at a level I trauma centre: time of day matters14. The diagnostic dilemma of shotgun injuries15. Evaluating the efficacy of self-study videos for the surgery clerkship rotation: an innovative project in undergraduate surgical education16. Systematic review and meta-analysis: preoperative anti-TNF therapy does not increase the risk of postoperative complications in patients with inflammatory bowel disease undergoing elective surgery17. Simulation platforms to assess laparoscopic suturing skills: a scoping review18. Cost analysis of simultaneous versus staged resection of colorectal cancer liver metastases: a population-based study19. Complementary and alternative medicine use among general surgery patients in Nova Scotia20. General surgery in Canada: current scope of practice and future needs21. Impact of dedicated operating time on access to surgical care in an acute care surgery model22. Adolescent appendicitis management and outcomes: comparison study between adult and pediatric institutions23. A systematic review of behavioural interventions to improve opioid prescribing after surgery24. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in trauma: a gap analysis of the Edmonton Zone Trauma Registry25. Learning by holographic anatomic models for surgical education26. The nature of learning from trauma team simulation27. Comparing reversing half-hitch alternating postsurgical knots and square knots for closure of enterotomy in a simulated deep body cavity: a randomized controlled trial28. Propagating the 'SEAD': exploring the value of an overnight call shift in the Surgical Exploration and Discovery Program29. Comparing 2 approaches to residency application file review30. A Canadian experience with posterior retroperitoneoscopic adrenalectomy31. A cost-efficient, realistic breast phantom for oncoplastic breast surgery training32. Impact of patient frailty on morbidity and mortality after common emergency general surgery operations33. Preventing opioid prescription after major surgery: a scoping review of the literature on opioid-free analgesia34. Correct usage of propensity score methodology in contemporary high-impact surgical literature35. Responsible blood compatibility testing for appendectomy: practice assessment at a single Canadian academic centre36. What patient factors are associated with participation in a provincial colorectal cancer screening program?37. Missed appendix tumours owing to nonoperative management for appendicitis38. Operative delay increases morbidity and mortality in emergency general surgery patients: a study of multiple EGS services within a single city39. Withdrawn40. Improved disease-free survival after prehabilitation for colorectal cancer surgery41. Development of a conceptual framework of recovery after abdominal surgery42. Comparison of Dor and Nissen fundoplication following laparoscopic paraesophageal hernia repair43. A systematic review and summary of clinical practice guidelines on the periprocedural management of patients on antithrombotic medications undergoing gastroenterological endoscopy44. Impact of socioeconomic status on postoperative complications following Whipple procedure for pancreatic ductal adenocarcinoma45. Clinical outcomes of high-risk breast lesions and breast cancer patients treated with total mastectomy and immediate reconstruction46. My On Call (MOC) Pager App: practising and assessing safe clinical decision-making47. Comprehensive complication index for major abdominal surgeries: an external validation using the American College of Surgeons’ National Surgical Quality Improvement Program (ACS NSQIP)48. The impact of surgeon experience on script concordance test scoring49. Decay of competence with extended research absences during postgraduate residency training: a scoping review50. Long-term outcomes of elderly patients managed nonoperatively for choledocholithiasis51. Predictors of mortality and cost among surgical patients admitted to hospital and requiring rapid response team activation52. Sex-based disparities in the hourly earnings of surgeons in Ontario’s fee-for-service system53. Outcomes of intestinal ischemia among patients undergoing cardiac surgery54. Factors influencing resident teaching evaluations: the relationship between resident interest in teaching, career plan, training level and their performance in teaching junior learners55. Validating a uniform system for measuring disease severity in acute colonic diverticulitis56. Active negative pressure peritoneal therapy and C-reactive protein (CRP) levels after abbreviated laparotomy for abdominal trauma or intraabdominal sepsis: the validity of serum and peritoneal CRP in measuring outcomes in critically ill patients57. Intraoperative use of indocyanine green fluorescence in emergency general surgery: a systematic review58. Is it safe? Nonoperaive management of blunt splenic injuries in geriatric trauma patients59. Bladder injury from laparoscopic appendicectomy: a multicentre experience over 5 years60. Perioperative cardiac investigations for chest pain after parathyroidectomy rarely yield a cardiac diagnosis61. Entero-hepatic axis injury following hemorrhagic shock: a role for uric acid62. Loss of functional independence after emergency abdominal surgery in older patients: a prospective cohort study63. Association between use of nonsteroidal antiinflammatory drugs, diuretics or angiotensin converting enzyme inhibitor/receptor blockers after major surgery and acute kidney injury: a nested, population-based case–control study64. Timing of CT for adhesive small bowel obstructions (SBO)65. The ABDO (Acute Biliary Disease Optimization) Study: improving the management of biliary diseases in emergency general surgery66. Rates and predictors of advanced biliary imaging and interventions in acute care surgery: a quality improvement study67. The use of early warning scores in patients undergoing emergency general surgery: a systematic review68. Does primary closure versus resection and anastomosis in patients with hollow viscus injury affect 30-day mortality?69. Impact of sarcopenia on morbidity and mortality after Whipple procedure for pancreatic ductal adenocarcinoma70. Mind the speaker gap: a cross-specialty analysis of the representation of women at surgical meetings in 5 different geographic regions71. Immediate breast reconstruction in locally advanced breast cancer: Is it safe?72. An administrative review of the incidence of adverse events involving electrocautery73. If you don’t document it, did it really happen? A review of the documentation of informed consent in laparoscopic cholecystectomy74. Can an online module help medical students gain confidence and proficiency in writing orders?75. The influence of undergraduate medical education anatomy exposure on choice of surgical specialty: a national survey76. Association between patient engagement and surgical outcomes: a pilot study77. Guidelines on the intraoperative transfusion of red blood cells: a systematic review78. Cancer is common in missed appendicitis: a retrospective cohort study79. Everyone is awesome: analyzing letters of reference in a general surgery residency selection process80. Evaluating the true additional costs of general surgery complications using a propensity score weighted model81. Deriving literature-based benchmarks for surgical complications from national databases in high-income countries: a systematic review on pancreatectomy outcomes82. The impact of distance on postoperative follow-up in pediatric general surgery patients: a retrospective review83. Water-soluble contrast in adhesive small bowel obstruction management: a Canadian centre’s experience84. Recognizing predatory journals in general surgery and their common violations85. Prophylactic negative pressure wound therapy for closed laparotomy incisions: a meta-analysis of randomized controlled trials86. Choosing Wisely Canada: 2019 general surgery recommendations87. Content-specific resident teaching can improve medical student learning outcomes on certifying examinations88. Transition to practice: preparedness for independent practice in general surgery graduates89. CAGS Exam 2.0: maximizing the potential for teaching and learning90. Resident attitudes toward the introduction of synoptic operative reporting for appendectomy and cholecystectomy91. Determining the individual, hospital and environmental cost of unnecessary laboratory investigations for patients admitted to general surgery services at an academic centre92. Gender-based compensation disparity among general surgeons in British Columbia93. Transgastric robotic resection for gastrointestinal stromal tumours of the stomach94. Recurrent gallstone ileus after laparoscopic-assisted enterolithotomy treated with totally laparoscopic enterolithotomy01. Predictors and outcomes among patients requiring salvage APR for the treatment of squamous cell carcinoma of the anus: a population-based study02. Short-course radiotherapy with perioperative systemic chemotherapy for patients with rectal cancer and synchronous resectable liver metastases: a single-centre Canadian experience03. Compliance with preoperative elements of the American Society of Colon and Rectal Surgeons rectal cancer surgery checklist improves pathologic and postoperative outcomes04. Clinical predictors of pathologic complete response following neoadjuvant chemoradiation therapy for rectal cancer: a systematic review and meta-analysis05. Rejected06. The impact of laparoscopic technique on the rate of perineal hernia after abdominoperineal resection of the rectum07. An assessment of the current perioperative practice, barriers and predictors for utilization of enhanced recovery after surgery protocols: a provincial survey08. Regional variation in the utilization of laparoscopy for the treatment of rectal cancer: the importance of fellowship training sites09. Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy: a systematic review and meta-analysis10. The relation between the gut microbiota and anastomotic leak in patients with colorectal cancer: a preliminary feasibility study11. Optimizing discharge decision-making in colorectal surgery: an audit of discharge practices in a newly implemented enhanced recovery pathway12. Trends in colectomy for colorectal neoplasms in ulcerative colitis (UC) patients over 2 decades: a National Inpatient Sample database analysis13. Spin in minimally invasive transanal total mesorectal excision articles (TaTME): an assessment of the current literature14. Venous thromboembolism (VTE) in colon cancer: a population-based cohort study of VTE rates following surgery and during adjuvant chemotherapy15. Robotic-assisted lateral lymph node dissection for rectal neuroendocrine tumor16. Loop ileostomy and colonic lavage as an alternative to colectomy for fulminant Clostridium difficile colitis17. Recurrent diverticulitis: Is it all in the family?18. Le traitement des fistules entérocutanées complexes : expérience du Centre hospitalier de l’Université de Montréal (CHUM)19. A North American single-blinded pilot randomized controlled trial for outpatient nonantibiotic management of acute uncomplicated diverticulitis (MUD TRIAL): feasibility and lessons learned20. Treatment failure after conservative management of acute diverticulitis: a nationwide readmission database analysis21. Impact of immunosuppression on mortality and major morbidity following sigmoid colectomy for diverticulitis: a propensity-score weighted analysis of the National Inpatient Sample22. Presentation and survival in colorectal cancer under 50 years of age: a systematic review and meta-analysis23. Genetics of postoperative recurrence of Crohn’s disease: a systematic review and meta-analysis24. Improving the identification and treatment of preoperative anemia in patients undergoing elective bowel resection25. Impact of postoperative complications on quality of life after colorectal surgery26. Colon cancer survival by subsite: a retrospective analysis of the National Cancer Database27. A second opinion for T1 colorectal cancer pathology reports results in frequent changes to clinical management28. Effects of the quadratus lumborum block regional anesthesia on postoperative pain after colorectal resection: a double-blind randomized clinical trial29. Safety of a short-stay postoperative unit for the early discharge of patients undergoing a laparosocpic right hemicolectomy30. What is the optimal bowel preparation to reduce surgical site infection in Crohn disease?31. TaTME surgery and the learning curve: our early experience32. Watch-and-wait experience in patients with rectal cancer: results in selected patients at a high-volume centre01. Automatic referral of suspicious findings detected on thoracic CT scan decreases delays in care without compromising referral quality02. Variation in receipt of therapy and survival with provider volume in noncurative esophagogastric cancer: a population-based analysis03. What makes patients high risk for lobectomy in the era of minimally invasive lobectomy?04. The value proposition of minimally invasive esophagectomy: a community hospital perspective05. Deviation from treatment plan in patients with potentially curable esophageal carcinoma06. Implementation of a standardized minimal opioid prescription for post-thoracic surgery patients is feasible and provides adequate pain control07. Sentinel node navigation surgery using indocyanine green in lung cancer: a systematic review and meta-analysis08. Surgical outcomes with trimodality neoadjuvant versus adjuvant therapy for esophageal cancer: results of the QUINTETT randomized trial09. Enhanced invasive mediastinal staging in an academic thoracic surgical unit by employing a shared accountability model for quality improvement10. Evaluation and harmonization of international database elements for adverse events monitoring following thoracic surgery: the pursuit of a common language11. Endobronchial ultrasound staging of operable non–small cell lung carcinoma: triple-negative lymph nodes may not require routine biopsy12. Wait times in the management of non-small cell lung cancer before, during and after regionalization of lung cancer care: a high-resolution analysis13. Wearable technology for preconditioning before thoracic surgery: a feasibility study14. Impact of carbohydrate-loading enhanced recovery after surgery protocol on adverse cardiopulmonary events in a thoracic surgery population15. Heat production during pulmonary artery sealing with energy vessel-sealing devices in a porcine model16. Who can afford to wait? The effect of wait times on survival in lung cancer patients: clinical predictors of poor outcomes17. Impact of the Integrated Comprehensive Care Program after thoracic surgery: a propensity score matched study18. Incidence, severity and risk of postoperative pulmonary complications in patients undergoing pulmonary resection for cancer19. Evaluation of the limits of use of a thoracoscopic lung palpation device to identify artificial tumour nodules in ex-vivo tissue20. Personalized surgical management of esophagogastric junction cancers21. Validity of a model to predict the risk of atrial fibrillation after thoracic surgery22. Severe symptoms persist for up to 1 year after diagnosis of stage I–III lung cancer: an analysis of province-wide patient-reported outcomes23. Do postoperative infectious adverse events influence cancer recurrence and survival after surgical resection of esophagogastric cancers? Experience from a Canadian university centre24. Utilization, safety and efficacy of hybrid esophagectomy on a population level25. Endoscopic submucosal dissection for upper gastrointestinal neoplasia: lessons learned from a high-volume North American centre26. Long-term quality of life after esophagectomy27. Early and late outcomes after surgery for pT4 NSCLC reclassified by AJCC 8th edition criteria28. Early results on the learning curve for subxiphoid video-assisted thoracoscopic lobectomy29. Should adjuvant therapy be offered for patients undergoing esophagectomy after neoadjuvant CROSS protocol for esophageal cancer? A multicentre cohort study30. Outcomes of patients discharged home with a chest tube following anatomic lung resection: a multicentre cohort study01. Management of cancer-associated intestinal obstruction in the final year of life02. Evaluating the prognostic significance of lymphovascular invasion in stage II and III colon cancer03. A matched case–control study on real-time electromagnetic navigation for breast-conserving surgery using NaviKnife04. Gaps in the management of depression symptom screening following cancer diagnosis: a population-based analysis of prospective symptom screening05. Patterns of symptom burden in neuroendocrine tumours: a population-based analysis of patient-reported outcomes06. Outcomes of salvage surgery for anal canal squamous cell carcinoma: a systematic review and meta-analysis07. Expression of the Plk4 inhibitor FAM46C predicts better survival following resection of gastric adenocarcinoma08. Current treatment strategies and patterns of recurrence in locally advanced colon cancer09. A 5-year retrospective review of outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in a provincial peritoneal malignancy program10. Withdrawn11. Geographic disparities in care and outcomes for noncurative pancreatic adenocarcinoma: a population-based study12. How often is implant-based breast reconstruction following postmastectomy radiation unsuccessful?13. Comparison of partial mastectomy specimen volume and tumour volume following neoadjuvant chemotherapy in breast cancer14. Two-year experience with hookwire localized clipped node and sentinel node as alternative to targeted axillary dissection in a regional centre15. Opioid use among cancer patients undergoing surgery and their associated risk of readmissions and emergency department visits in the 1-year postsurgical period16. Preliminary results of a pilot randomized controlled trial comparing axillary reverse mapping with standard axillary surgery in women with operable breast cancer17. Complementary and alternative medicine among general surgery patients in Nova Scotia18. Improving wait times and patient experience through implementation of a provincial expedited diagnostic pathway for BI-RADS 5 breast lesions19. Population-based regional recurrence patterns in Merkel cell carcinoma: a 15-year review20. Survival and health care cost benefits of high-volume care in the noncurative management of pancreatic adenocarcinoma: a population-based analysis21. Trends in the use of sentinel node biopsy after neoadjuvant chemotherapy in the United States22. Predictors of grossly incomplete resection in primary retroperitoneal sarcoma (RPS)23. Mastectomy versus breast conservation therapy: an examination of how individual, clinicopathologic and physician factors influence decision making24. Immunophenotyping postoperative myeloid-derived suppressor cells in cancer surgery patients25. Adherence to sentinel lymph node biopsy guidelines in the management of cutaneous melanoma in the province of British Columbia26. Breast cancer with supraclavicular and internal mammary node metastases: therapeutic options27. Textbook outcomes and survival in patients with gastric cancer: an analysis of the population registry of esophageal and stomach tumours of Ontario (PRESTO)28. Withdrawn29. Symptomatic bowel complications in patients with metastatic cancer: comparison of surgical versus medical outcomes and development of a prediction model for successful surgical palliation30. Rejected31. Gastric cancer biopsies show distinct biomarker profiles compared with normal gastric mucosa in Canadian patients32. Withdrawn01. Management of high patient-reported pain scores in noncurative pancreatic adenocarcinoma: a population-based analysis02. Outcomes of liver donors with a future liver remnant less than or equal to 30%: a matched-cohort study03. The applicability of intraoperative fluorescent imaging with indocyanine green in hepatic resection for malignancy: a systematic review and meta-analysis04. Impact of adjuvant chemotherapy completion on outcomes following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma05. Primary hepatic acinar cell carcinoma06. Laparoscopic distal pancreatectomy provides equivalent oncologic outcomes for pancreatic ductal adenocarcinoma07. Passive versus active intraabdominal drainage following pancreatic resection: Does a superior drainage system exist? A systematic review and meta-analysis08. Low yield of preoperative MRCP and ERCP in the management of low-intermediate suspicion choledocholithiasis09. Pancreatic cancer resection rates and survival in the United States and Canada10. Prognostic value of immune heterogeneity in colorectal cancer liver metastases11. Impact of intraoperative hypovolemic phlebotomy on blood loss and perioperative transfusion in patients undergoing hepatectomy for cancer12. Prediction of postoperative pancreatic fistula following pancreatectomy: a systematic review of clinical tools13. The impact of preoperative frailty in liver resection: an analysis of the American College of Surgeons’ National Surgical Quality Improvement Program (ACS NSQIP)14. Topical agents as adjuncts in pancreatic surgery for prevention of postoperative pancreatic fistula: a systematic review and meta-analysis15. Phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections (PRICE-1): a feasibility randomized controlled trial16. Pylorus-preserving versus classic pancreaticoduodenectomy: a single-centre retrospective review of total lymph node yield17. An audit and evaluation of appropriateness of intraoperative allogenic red blood cell transfusion in liver surgery: application of 3 decision rules18. A comparison of lymph node ratio with AJCC lymph node status for survival after Whipple resection for pancreatic adenocarcinoma19. Duodenopancréatectomie céphalique (intervention de Whipple) par voie laparoscopique pure20. Use of the Molecular Adsorbent Recirculating System (MARS) in acute liver failure: a multicentre experience21. Barriers to adjuvant chemotherapy after resection for pancreatic cancer22. Comparison of primary and metastatic pancreatic cancer by clinical and genomic features23. Factors associated with invasion and postoperative overall survival in resected IPMN01. Incisional hernia repair surgery improves patient-reported outcomes02. Prospective study of single-stage repair of contaminated hernias with the novel use of calcium sulfate antibiotic beads in conjunction with biologic porcine submucosa tissue matrix03. e-TEP transversus abdominus release04. Umbilical hernias05. Review of 1061 femoral hernias done at the Shouldice Hospital over a period of 6 years01. Metabolic outcomes after bariatric surgery for a provincial Indigenous population02. Outcomes of sleeve gastrectomy performed in a regional hospital03. A longitudinal analysis of wait times in a publicly funded, regionalized bariatric care system04. Concurrent laparoscopic ventral hernia repair with bariatric surgery: a propensity-matched analysis05. Outcomes from explantation of laparoscopic adjustable gastric band: experience from a Canadian bariatric centre of excellence06. Development of consensus-derived quality indicators for laparoscopic sleeve gastrectomy07. Conversion of sleeve gastrectomy to laparoscopic Roux-en-Y gastric bypass in intestinal nonrotation08. The utility of routine preoperative upper gastrointestinal series for laparoscopic sleeve gastrectomy09. Body image concerns, depression, suicidality and psychopharmacological changes in postoperative bariatric surgery patients: a mixed-methods study10. Technical factors associated with early sleeve stenosis after sleeve gastrectomy: an analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database11. Analysis of complication and readmission rates after laparoscopic sleeve gastrectomy at a single bariatric surgery centre: a retrospective NSQIP study12. Management of common bile duct stones in patients after Roux-en-Y gastric bypass: a systematic review13. Improvement and resolution of urinary incontinence after bariatric surgery: a systematic review and meta-analysis14. Bridging interventions for weight loss prior to bariatric surgery in patients with superobesity: a systematic review and meta-analysis15. Secondary and tertiary learning curves in bariatric surgery16. Achalasia following laparoscopic sleeve gastrectomy: a case report17. Multidisciplinary approach to halving length of stay after bariatric surgery18. Prospective analysis of staple line haemostatic materials in stapled bariatric surgery19. Barriers and facilitators to managing patients with class II and III obesity in primary care: a qualitative study20. The Edmonton Obesity Staging System predicts risk of postoperative complications and mortality following bariatric surgery21. The impact of attention-deficit/hyperactivity disorder on bariatric surgery outcomes: systematic review and meta-analysis22. The effect of bariatric surgery on migraines: a systematic review and meta-analysis23. A population-based matched cohort study of mortality after bariatric surgery24. Safety and outcomes of bariatric surgery performed at an ambulatory site associated with a tertiary care hospital in Canada25. Race and sex predict adverse outcomes following bariatric surgery: a propensity-matched MBSAQIP analysis26. A survey of primary care physician referral to bariatric surgery: access, perceptions and barriers

Author

M. El-Beheiry, V. Mocanu, S. Deghan Manshadi, A. Doumouras, J. Lee, I. Tavakoli, S. Skulsky, B. Zevin, H. Cheah, D. Pace, S. Seidl, R. Malhan, J. Yu, Z. Mir, A. McLean, J. Dang, K. Bartellas, W. Sun, N. Hanna, S. Stogryn, M. Moolla, S. Albacete, N. Ares Bruneau, O. Lovrics, R. Bendavid, F. Saleh, A. Drohan, S. Manoharan, A. Connor, J. Li, A. MacDonald, E. Girard, Y. Essaji, L. Baker, E. Theodosopoulos, C. Garcia-Ochoa, V. Zuk, M. Al Khaldi, D. Henault, J. Levy, Y. Wang, M. Driedger, J. Grab, R. Liu, K. Purich, J. Zuckerman, S. Tung, D. Skubleny, H. Li, L. Meloche-Dumas, S. Ollek, L. Angka, J. Gu, D. Ng, G. Gauvin, N. Coburn, M. Talbot, A. Laws, E. Roach, P. Lovrics, R. Tamblyn, A. Bazzarelli, E. Yee, N. Jedrzejko, C. Huynh, S. Luu, D. Cyr, J. Hallet, C. Yeo, D. Mutabdzic, S. Merchant, Y. Shargall, R. Ben-Avi, A. Katz, J. Mouhanna, J. Cools-Lartigue, A. Chen, V. Gupta, S. Gowing, H. Smith, A. Kammili, R. Ralph-Edwards, N. Seyednejad, N. Ahmadi, E. Goudie, E. MacKay, Y. Patel, S. Shakeel, D. Hylton, G. Sigler, V. Resende, R. Malthaner, N. Safieddine, M. Thivierge-Southidara, M. Bushra, L. Donahoe, T. Khalid, J. Rousseau, A. Pooni, D. Jones, M. Boulianne, M. Dykstra, D. Yu, T. Dumitra, R. Gilbert, M. Laffin, C. Griffiths, S. Al-Masrouri, M. Gagnon-Konamna, T. Almalki, T. McKechnie, L. Zhang, A. Ni, N. Caminsky, R. Hajjar, A. Motamedi, J. Springer, A. Black, N. Wong-Chong, R. Garfinkle, A. Pang, G. Ko, S. Lo, S. Neri, Z. Sagorin, A. Lalande, M. Lipson, C. Gomez-Garibello, M. Parapini, N. Zondervan, L. Abraham, T. Kuper, M. Mohammed, B. Elsolh, M. Wiebe, M. Horkoff, N. AlShahwan, C. Towaij, E. Walser, T. Wijayanayaka, S. Nanji, B. Giammarioli, K. Taqi, A. Arora, L. Qu, J. Beattie-Booth, D. Laczko, C. Way, K. D’Souza, M. Nguyen, D. Roberts, T. Wong, F. Khazoom, D. Lustig, M. Trust, S. Alqahtani, A. Kirkpatrick, E. Tang, G. Pang, J. Holden, F. Dossa, A. Tran, K. Edwards, N. Gawad, V. Pravong, L. Glass, H. Ahn, M. Trepanier, R. Alam, M. Meschino, L. Findlay-Shirras, S. Godzisz, E. Grose, G. Olleik, P. Murphy, G. Aldosary, K. Garber, J. Younan, T. Ziegler, M. Lemke, F. Shariff, R. Leung, A. Eksteen, D. Zhang, J. Schendel, A. Albarrak, T. Schroeder, J. Wang, E. Bilgic, L. Yang, N. Mookerji, M. Schellenberg, B. Zhang, J. Bogach, L. Streith, A. Kleiman, D. DeGirolamo, E. Clement, P. Vourtzoumis, S. Lim, W. Marini, G. Johal, M. Strickland, A. Madani, A. Lee, A. Ericson, C. Gratton, J. Ryan, T. Clements, M. Kim, C. Ball, S. Widder, D. Hwang, B. Mador, B. Greenberg, M. Ott, J. Silverberg, S. Parpia, R. Saskin, L. Ruo, M. Simunovic, P. Serrano, S. Ghazi Faisal, M. Pinto Sanchez, S. Cleary, K. Inaba, P. Heindel, S. Biswas, E. Benjamin, A. Strumwasser, K. Matsushima, L. Lam, D. Demetriades, J. Bardes, B. Love, Z. Warriner, M. Forestiere, D. Clark, J. El Haddad, P. Thin Vo, B. Lam, C. Seabrook, R. Feibel, S. Bennett, A. Istl, M. Alyafi, T. Hada, T. Landry, G. Fried, M. Vassiliou, C. Gu, A. Gafni, L. Helyer, C. Sheppard, D. Wilson, C. Champion, S. DiMillo, R. Kirkpatrick, S. Hiscock, R. Friesen, L. Smithson, P. Miles, C. Chiu, O. Panton, A. Meneghetti, M. Meloche, A. Liu, L. Chen, N. Yanchar, J. Sussman, N. Jivraj, B. Speller, A. Ruco, K. Ladha, S. Brar, D. Urbach, D. Wijeysundera, A. Tricco, H. Clarke, N. Baxter, D. O’Dochartaigh, J. Odenbach, M. Douma, R. Anantha, G. Regehr, R. Hatala, E. Sykes, D. Potter, T. Li, E. Khong, G. Sheahan, V. Wu, A. Adibfar, A. Abbasian, S. Jiang, J. Rutka, I. Raiche, A. Melck, T. Tse, A. Arnaout, J. Caudrelier, C. Foottit, E. Vandervoort, J. Belec, S. Savage, B. Zarzaur, B. Verdolin, A. Kouyoumdjian, C. El Kefraoui, A. Alldrit, A. Figueiredo, S. Valanci, J. Velasco, M. Schulz, D. Mouldoveanu, P. Nguyen-Powanda, G. Best, A. Banks, N. Pecorelli, G. Baldini, L. Feldman, J. Fiore, S. Wilson, J. Barkun, K. Bertens, G. Martel, F. Balaa, J. Abou Khalil, S. Lethbridge, R. Nenshi, K. Decker, H. Singh, N. Biswanger, J. Park, K. Wong, A. Giles, T. Rice, P. Engels, E. Minnella, T. Paradis, R. Awasthi, P. Kaneva, K. Schwartzman, F. Carli, L. Lee, J. Montanez, S. Law, Y. Watanabe, L. Chiavegato, M. Falconi, H. Satoshi, N. Mayo, R. Sorial, A. Siblini, L. Ferri, C. Mueller, S. Khair, E. Saidenberg, E. Kelly, C. Garcia Ochoa, L. Allen, K. Leslie, P. Dubé, G. Leblanc, L. Sideris, D. Borsuk, M. Tardif, C. Guertin, A. Chollet, M. Gervais, A. Boulay, H. McDonald, F. Rubens, E. McArthur, A. Skaro, A. Malvea, T. Wood, L. Cowley, M. Allen, A. Fowler, R. Visser, J. Bednarz, A. Tago, A. Baergan, A. Beaumont, K. Kroeker, R. Dale, A. McKay, S. Fernando, D. McIsaac, B. Rochwerg, G. Mok, A. Seely, D. Kubelik, D. Kim, P. Reardon, J. Shen, P. Tanuseputro, K. Thavorn, K. Kyeremanteng, A. Simpson, R. Sutradhar, G. Tomlinson, A. Detsky, I. Grant, A. Warraich, L. Hashem, D. Tran, H. Moloo, R. Musselman, L. Williams, J. Van Koughnett, K. Vogt, B. Huang, C. Doig, F. Al Hinai, P. Teixeira, L. Brown, S. Ali, B. Coopwood, J. Aydelotte, C. Brown, S. DiLernia, S. Chia, N. Nadkarni, D. Seow, S. Smith, Z. Tan, E. Dixon, I. Datta, A. Devrome, B. Hemmelgarn, M. Tonelli, N. Pannu, M. James, D. Naidu, A. Nadler, D. Ko, K. Martyn, V. Zou, P. Dawe, M. Hameed, A. Ferguson, B. Moffat, C. Frank, A. Beckett, K. Khwaja, P. Fata, D. Deckelbaum, T. Razek, J. Grushka, M. Roth, D. Wiseman, C. Yoshy, Y. Kaur, D. Little, J. Pao, E. Mckevitt, C. Dingee, R. Warburton, H. Quereshy, C. Masino, A. Maeda, T. Jackson, A. Okrainec, R. Selvam, E. Williams, J. Davidson, A. Butter, C. Eskicioglu, S. Reid, J. Mata, L. Park, A. Davis, A. Tinmouth, D. Fergusson, A. Maciver, S. Fraser, O. Daodu, C. Graham, D. Urban, M. Brindle, A. Shawyer, R. Hilsden, T. Ribeiro, A. Siddiqui, N. Alkhamesi, B. Kaur, D. Mok, S. Chadi, A. MacNeill, F. Wright, K. McLaughlin, T. Scott, A. Karimuddin, M. Wagner, B. Vair, T. Maclean, K. Spoyalo, D. Schaeffer, A. Guo, S. Brogly, K. Lajkosz, T. Hanna, M. Kalyvas, M. Raphael, C. Booth, S. Patel, S. Faria, N. Kopek, T. Hijal, A. Liberman, P. Charlebois, B. Stein, C. Vasilevsky, G. Ghitulescu, N. Morin, J. Faria, M. Boutros, Y. Xiao, M. Raval, T. Phang, S. Forbes, N. Amin, M. Cadeddu, D. Hong, N. Mak, P. Phang, G. Fragoso, F. Dagbert, É. DeBroux, R. Loungnarath, H. Sebajang, F. Schwenter, R. Ratelle, R. Wassef, A. Calvé, M. Constante, G. Ebead, C. Péthel, M. Santos, C. Richard, D. Hamad, B. He, K. Zhao, M. Alqahtani, M. Abou Khalil, D. Marinescu, A. Chadi, S. Wei, P. James, Y. Lee, E. Kmiotek, V. Pelsser, P. Bonaffini, C. Reinhold, P. Yousef, S. Liberman, E. De Broux, E. Salama, S. Lachance, S. Sabboobeh, J. Savard, F. Alrashid, T. Dang, T. Chambers, E. Wine, B. Dicken, K. Madsen, J. Greenberg, T. Zwiep, D. Touchie, D. McIsacc, M. Stem, J. Taylor, S. Chen, B. Safar, S. Fang, S. Gearhart, J. Efron, T. Gimon, W. Buie, A. MacLean, P. Paquet, R. Veilleux, S. Drolet, D. Simonyan, A. Turgeon, S. Zerhouni, P. Karanicolas, S. Ashamalla, M. Brar, A. De Buck van Overstraeten, R. Gryfe, H. MacRae, E. Kennedy, T. McAlister, J. Veenstra, K. Stewart, A. Valji, E. Bédard, S. Johnson, B. Laing, S. Turner, L. Davis, A. Mahar, Y. Liu, C. Earle, C. Kavanagh, T. Waddell, J. Yeung, M. Cypel, M. de Perrot, A. Pierre, S. Keshavjee, K. Yasufuku, G. Darling, A. Mohammed, S. Uddin, A. Behzadi, C. Vincelette, J. Molina, E. Lafontaine, J. Martin, B. Nasir, P. Ferraro, M. Liberman, C. Simone, S. Gazala, R. Zeldin, N. Safiedddine, A. Modasi, A. Nasralla, N. Switzer, D. Birch, S. Karmali, E. Yu, M. Sanatani, D. Lewis, A. Warner, A. Dar, B. Yaremko, J. Bierer, D. Palma, G. Rodrigues, D. Fortin, R. Inculet, E. Frechette, J. Raphael, S. Gaede, S. Kuruvilla, J. Younus, M. Vincent, J. Villeneuve, M. Legacy, C. Anstee, D. Maziak, F. Shamji, S. Sundaresan, S. Gilbert, K. Selvakumaran, B. Kidane, J. Spicer, D. French, C. Wen, J. Masters, C. Finley, F. Farrokhyar, J. Agzarian, W. Hanna, M. Dhanoa, O. Khan, N. Akhtar-Danesh, P. Dibajnia, M. Rok, M. Beauchamp, J. Wald, L. Mbuagbaw, null Fahim, E. Alghunaim, A. McGuire, R. Oliveira, V. Thiffault, A. Jouquan, R. Hadjeres, J. Berdugo, S. Karri, P. Villeneuve, S. Gagne, C. Thompson, C. Nicholson-Smith, M. Naish, R. Patel, O. Brandts-Longtin, C. Yeung, R. Passman, D. Hirpara, H. Zhao, R. Sutradhr, M. Doherty, A. Louie, A. Mattice, M. Shen, P. Carroll, M. Chen, M. Mulder, P. Fiset, R. Rayes, E. Lee, C. Sirois, D. Mulder, J. Lorange, E. Tawfik, L. Aubin, J. Eustache, F. Aburaida, E. Bedard, M. Coret, M. Ferguson, Y. Lopez-Hernandez, L. Schneider, F. Minervini, A. Brunelli, T. Miyazaki, L. Bertolaccini, M. Scarci, K. Hughes, C. Goldie, Y. Peng, S. O’Brien, S. Reddy, E. Sigurdson, C. Denlinger, J. Meyer, J. Farma, T. Ungi, A. Lasso, D. Jabs, T. Vaughan, J. Rudan, R. Walker, G. Fichtinger, C. Engel, E. Isenberg-Grzeda, L. Moody, C. Law, L. Bubis, S. Singh, S. Myrehaug, K. Beyfuss, P. Savage, T. Chesney, C. Swallow, K. Kazazian, J. Conner, J. Swett-Cosentino, K. Pacholczyk, A. Govindarajan, S. Minkova, H. Stuart, T. Hamilton, Y. McConnell, S. Chambers, S. Latosinsky, A. Grant, F. Angarita, K. Carpenter, R. Au, D. McCready, T. Cil, M. Elmi, R. Poon, A. Meguerditchian, S. Kurteva, N. Hodgson, S. Cornacchi, E. Parvez, I. Dayes, M. Forbes, L. Thabane, A. Crocker, J. Dort, D. Olson, A. Elwi, S. Anderes, S. Parker, A. Estey, A. Keehn, M. Quan, N. Look-Hong, N. Mittmann, N. Melchior, D. Sachs, C. Chang, C. Wang, A. Aggon, J. Daly, R. Bleicher, D. Callegaro, C. Raut, D. Strauss, C. Honore, E. Stoeckle, S. Bonvalot, W. Van Houdt, P. Rutkowski, Y. Schrage, M. Fiore, M. Delisle, R. Engler-Stringer, G. Groot, M. Andre, A. Jeong, M. Scaffidi, M. Market, L. Kuhlmann, T. Kislinger, R. Auer, M. Martinka, N. Davis, A. McFadden, A. Christopoulos, T. Ayad, R. Younan, A. Kaviani, K. Boulva, A.-A. Bernard, J. Beaulieu, P. Borduas, N. El Sayed, X. Ma, E. Sédillot, É. Patocskai, C. Allen-Ayodabo, E. Amirazodi, Q. Li, O. Saarela, C. De Mestral, B. Dingley, J. Dobransky, C. Nessim, E. Boivin, S. Bhavanam, S. Garg, R. McLean, M. McCall, D. Schiller, G. Rayat, A. Nathens, A. Gorgen, S. Acuña, N. Goldaracena, M. Cattral, A. Ghanekar, I. McGilvray, D. Grant, G. Sapisochin, A. Poonja, D. Bigam, D. Breadner, S. Welch, D. Rayner, N. Kneteman, M. Kendrick, J. Abou-Khalil, D. Mergui, J. Pelletier, T. Vanounou, M. Guttman, P. Saint-Hilaire, D. Stephen, N. Messaoudi, M. Plasse, A. Roy, M. Dagenais, R. Létourneau, R. Lapointe, F. Vandenbroucke-Menu, G. Soucy, S. Turcotte, F. Gryspeerdt, C. Bouchard, L. Massicotte, B. Rioux-Massé, F. Carrier, M. Segedi, J. Ouellet, C. Wherrett, A. Workneh, K. Gadbois, R. Jee, J. McVicar, P. Rao, P. Wong, S. Saeed, B. Shropshire, J. Olson, C. Karvellas, E. Vasilyeva, D. Renouf, S. Chung, C. Scudamore, A. Buczkowski, P. Kim, S. Gallinger, A. Wei, G. Liu, T. Crump, J. Sutherland, S. Minor, M. Mainprize, S. Gmora, M. Anvari, D. Khalil, R. Villiard, P. Koch, L. Windisch, M. Pyarali, S. Byrns, S. MacLellan, A. Vergis, A. Sharples, K. Hardy, D. Smith, N. Slater, S. Malik, T. Bao, K. Tikkinen, M. Pedziwiatr, P. Major, I. Aditya, Y. Krakowsky, C. Stockley, N. Dalgarno, M. Martin, C. Grady, R. Houlden, R. Birtwhistle, K. Smith, R. Morkem, D. Barber, A. Sharma, J. Kung, A. Mann, G. Babe, K. Dehghan, C. Reimer, D. Robertson, J. Choi, and K. Clouston

Subjects
Surgery
Published
2019

58. Evaluation of Simple Amides in the Selective Recovery of Gold from Secondary Sources by Solvent Extraction

Author

Andrew J. Duffy, Innis Carson, Carole A. Morrison, Peter A. Tasker, Izabela A. Kordas, Eddie Shao, Jason B. Love, Bryne T. Ngwenya, Luke M. M. Kinsman, Euan D. Doidge, and Yiran Ji

Subjects
General Chemical Engineering, Supramolecular chemistry, CATALYSTS, Protonation, 02 engineering and technology, recycling, 010402 general chemistry, WEEE, 01 natural sciences, Electronic waste, Catalysis, Gold iii, DESIGN, Environmental Chemistry, SPHERE COORDINATION CHEMISTRY, GOLD(III), Solvent extraction, Simple (philosophy), computational, METAL RECOVERY, Renewable Energy, Sustainability and the Environment, Chemistry, General Chemistry, AGGREGATION, 021001 nanoscience & nanotechnology, Combinatorial chemistry, humanities, 0104 chemical sciences, PROTONATION, ELECTRONIC WASTE, 0210 nano-technology, supramolecular
Abstract

The recycling of metals from end-of-life secondary sources such as electronic waste remains a significant environmental and technological challenge currently detrimental to the development of circular economies. The complex nature of electronic waste, containing a myriad of different elemental metals, means that sophisticated yet simple separation methods need to be developed in order to recycle these valuable and often critical metal resources. In this work simple primary, secondary, and tertiary amides are appraised as reagents that selectively transport gold from aqueous to organic phases in a solvent extraction experiment. While the strength of extraction of gold from single metal solutions is ordered 3o>2o>1o, the 3o and 2o amides are ineffective at gold transport from mixed-metal solutions of concentrations representative of smartphones due to the formation of a third, dense phase. Increasing the polarity of the organic phase can negate third phase formation but at the expense of selectivity. The identities of the species that reside in the organic and third phases have been studied by a combination of slope analysis, mass spectrometry, NMR spectroscopy, and computational methods. These techniques show that protonation of the amide L occurs at the oxygen atom, resulting in the protonated dimer HL2+ which acts as a receptor for AuCl4− to form dynamic supramolecular aggregates in the organic phase. The characterization of a tin complex in the third phase by X-ray crystallography supports these conclusions and furthermore, suggests the preference for the chelation of the proton by two amide molecules instead of the transport of hydronium into the organic phase and its subsequent use as structural template.

Published
2019

59. Severe Ehrlichia chaffeensis Infection in a Lung Transplant Recipient: A Review of Ehrlichiosis in the Immunocompromised Patient

Author

Nasia Safdar, Robert B. Love, and Dennis G. Maki

Subjects
ehrlichiosis, immunocompromised host, thrombotic thrombocytopenia purpura, United States, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We describe a case of human ehrlichiosis in a lung transplant recipient and review published reports on ehrlichiosis in immunocompromised patients. Despite early therapy with doxycycline, our patient had unusually severe illness with features of thrombotic thrombocytopenic purpura. Of 23 reported cases of ehrlichiosis in immunocompromised patients, organ failure occurred in all patients and 6 (25%) died.

Published
2002
Full Text
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60. PHENIX Collaboration

Author

A. Adare, S. Afanasiev, C. Aidala, N.N. Ajitanand, Y. Akiba, R. Akimoto, H. Al-Bataineh, J. Alexander, M. Alfred, A. Al-Jamel, H. Al-Ta'ani, K.R. Andrews, V. Andrieux, A. Angerami, K. Aoki, N. Apadula, L. Aphecetche, E. Appelt, Y. Aramaki, R. Armendariz, S.H. Aronson, J. Asai, H. Asano, E.C. Aschenauer, E.T. Atomssa, R. Averbeck, T.C. Awes, C. Ayuso, B. Azmoun, V. Babintsev, A. Bagoly, M. Bai, X. Bai, G. Baksay, L. Baksay, A. Baldisseri, N.S. Bandara, B. Bannier, K.N. Barish, P.D. Barnes, B. Bassalleck, A.T. Basye, S. Bathe, S. Batsouli, V. Baublis, F. Bauer, C. Baumann, S. Baumgart, A. Bazilevsky, M. Beaumier, S. Beckman, S. Belikov, R. Belmont, J. Ben-Benjamin, R. Bennett, A. Berdnikov, Y. Berdnikov, J.H. Bhom, A.A. Bickley, M.T. Bjorndal, D. Black, D.S. Blau, M. Boer, J.G. Boissevain, J.S. Bok, H. Borel, K. Boyle, M.L. Brooks, D.S. Brown, D. Broxmeyer, J. Bryslawskyj, D. Bucher, H. Buesching, V. Bumazhnov, G. Bunce, J.M. Burward-Hoy, C. Butler, S. Butsyk, C.M. Camacho, S. Campbell, V. Canoa Roman, A. Caringi, P. Castera, R. Cervantes, J.-S. Chai, B.S. Chang, W.C. Chang, J.-L. Charvet, C.-H. Chen, S. Chernichenko, C.Y. Chi, J. Chiba, M. Chiu, I.J. Choi, J.B. Choi, S. Choi, R.K. Choudhury, P. Christiansen, T. Chujo, P. Chung, A. Churyn, O. Chvala, V. Cianciolo, Z. Citron, C.R. Cleven, Y. Cobigo, B.A. Cole, M.P. Comets, Z. Conesa del Valle, M. Connors, P. Constantin, N. Cronin, N. Crossette, M. Csanád, T. Csörgő, T. Dahms, S. Dairaku, I. Danchev, T.W. Danley, K. Das, A. Datta, M.S. Daugherity, G. David, M.K. Dayananda, M.B. Deaton, K. DeBlasio, K. Dehmelt, H. Delagrange, A. Denisov, D. d'Enterria, A. Deshpande, E.J. Desmond, K.V. Dharmawardane, O. Dietzsch, L. Ding, A. Dion, P.B. Diss, D. Dixit, J.H. Do, M. Donadelli, L. D'Orazio, J.L. Drachenberg, O. Drapier, A. Drees, K.A. Drees, A.K. Dubey, M. Dumancic, J.M. Durham, A. Durum, D. Dutta, V. Dzhordzhadze, S. Edwards, Y.V. Efremenko, J. Egdemir, T. Elder, F. Ellinghaus, W.S. Emam, T. Engelmore, A. Enokizono, H. En'yo, B. Espagnon, S. Esumi, K.O. Eyser, B. Fadem, W. Fan, N. Feege, D.E. Fields, M. Finger, F. Fleuret, S.L. Fokin, B. Forestier, Z. Fraenkel, J.E. Frantz, A. Franz, A.D. Frawley, K. Fujiwara, Y. Fukao, Y. Fukuda, S.-Y. Fung, T. Fusayasu, S. Gadrat, K. Gainey, C. Gal, P. Gallus, P. Garg, A. Garishvili, I. Garishvili, F. Gastineau, H. Ge, M. Germain, F. Giordano, A. Glenn, H. Gong, X. Gong, M. Gonin, J. Gosset, Y. Goto, R. Granier de Cassagnac, N. Grau, S.V. Greene, G. Grim, M. Grosse Perdekamp, Y. Gu, T. Gunji, L. Guo, H. Guragain, H.-Å. Gustafsson, T. Hachiya, A. Hadj Henni, C. Haegemann, J.S. Haggerty, M.N. Hagiwara, K.I. Hahn, H. Hamagaki, J. Hamblen, H.F. Hamilton, R. Han, S.Y. Han, J. Hanks, H. Harada, C. Harper, E.P. Hartouni, K. Haruna, M. Harvey, S. Hasegawa, T.O.S. Haseler, K. Hashimoto, E. Haslum, K. Hasuko, R. Hayano, S. Hayashi, X. He, M. Heffner, T.K. Hemmick, T. Hester, J.M. Heuser, H. Hiejima, J.C. Hill, K. Hill, R. Hobbs, M. Hohlmann, R.S. Hollis, M. Holmes, W. Holzmann, K. Homma, B. Hong, T. Horaguchi, Y. Hori, D. Hornback, T. Hoshino, N. Hotvedt, J. Huang, S. Huang, M.G. Hur, T. Ichihara, R. Ichimiya, J. Ide, H. Iinuma, Y. Ikeda, K. Imai, Y. Imazu, J. Imrek, M. Inaba, Y. Inoue, A. Iordanova, D. Isenhower, L. Isenhower, M. Ishihara, A. Isinhue, T. Isobe, M. Issah, A. Isupov, Y. Ito, D. Ivanishchev, Y. Iwanaga, B.V. Jacak, M. Javani, S.J. Jeon, M. Jezghani, Z. Ji, J. Jia, X. Jiang, J. Jin, O. Jinnouchi, D. John, B.M. Johnson, T. Jones, E. Joo, K.S. Joo, V. Jorjadze, D. Jouan, D.S. Jumper, F. Kajihara, S. Kametani, N. Kamihara, J. Kamin, S. Kanda, M. Kaneta, S. Kaneti, B.H. Kang, J.H. Kang, J.S. Kang, H. Kanou, D. Kapukchyan, J. Kapustinsky, K. Karatsu, S. Karthas, M. Kasai, T. Kawagishi, D. Kawall, M. Kawashima, A.V. Kazantsev, S. Kelly, T. Kempel, J.A. Key, V. Khachatryan, P.K. Khandai, A. Khanzadeev, K. Kihara, K.M. Kijima, J. Kikuchi, A. Kim, B.I. Kim, C. Kim, D.H. Kim, D.J. Kim, E. Kim, E.-J. Kim, G.W. Kim, H.-J. Kim, H.J. Kim, K.-B. Kim, M. Kim, M.H. Kim, S.H. Kim, Y.-J. Kim, Y.K. Kim, Y.-S. Kim, B. Kimelman, D. Kincses, E. Kinney, K. Kiriluk, Á. Kiss, E. Kistenev, R. Kitamura, A. Kiyomichi, J. Klatsky, J. Klay, C. Klein-Boesing, D. Kleinjan, P. Kline, T. Koblesky, L. Kochenda, V. Kochetkov, M. Kofarago, Y. Komatsu, B. Komkov, M. Konno, J. Koster, D. Kotchetkov, D. Kotov, A. Kozlov, A. Král, A. Kravitz, F. Krizek, P.J. Kroon, J. Kubart, S. Kudo, G.J. Kunde, N. Kurihara, K. Kurita, M. Kurosawa, M.J. Kweon, Y. Kwon, G.S. Kyle, R. Lacey, Y.S. Lai, J.G. Lajoie, E.O. Lallow, D. Layton, A. Lebedev, Y. Le Bornec, S. Leckey, B. Lee, D.M. Lee, G.H. Lee, J. Lee, K. Lee, K.B. Lee, K.S. Lee, M.K. Lee, S. Lee, S.H. Lee, S.R. Lee, T. Lee, M.J. Leitch, M.A.L. Leite, M. Leitgab, E. Leitner, B. Lenzi, Y.H. Leung, B. Lewis, N.A. Lewis, X. Li, X.H. Li, P. Lichtenwalner, P. Liebing, H. Lim, S.H. Lim, L.A. Linden Levy, T. Liška, A. Litvinenko, H. Liu, L.D. Liu, M.X. Liu, V.-R. Loggins, S. Lokos, K. Lovasz, B. Love, R. Luechtenborg, D. Lynch, C.F. Maguire, T. Majoros, Y.I. Makdisi, M. Makek, M. Malaev, A. Malakhov, M.D. Malik, A. Manion, V.I. Manko, E. Mannel, Y. Mao, L. Mašek, H. Masuda, H. Masui, S. Masumoto, F. Matathias, M.C. McCain, M. McCumber, P.L. McGaughey, D. McGlinchey, C. McKinney, N. Means, A. Meles, M. Mendoza, B. Meredith, W.J. Metzger, Y. Miake, T. Mibe, J. Midori, A.C. Mignerey, D.E. Mihalik, P. Mikeš, K. Miki, A.J. Miller, T.E. Miller, A. Milov, S. Mioduszewski, D.K. Mishra, G.C. Mishra, M. Mishra, J.T. Mitchell, M. Mitrovski, G. Mitsuka, Y. Miyachi, S. Miyasaka, S. Mizuno, A.K. Mohanty, S. Mohapatra, P. Montuenga, H.J. Moon, T. Moon, Y. Morino, A. Morreale, D.P. Morrison, S.I.M. Morrow, M. Moskowitz, J.M. Moss, S. Motschwiller, T.V. Moukhanova, D. Mukhopadhyay, T. Murakami, J. Murata, A. Mwai, T. Nagae, K. Nagai, S. Nagamiya, K. Nagashima, T. Nagashima, Y. Nagata, J.L. Nagle, M. Naglis, M.I. Nagy, I. Nakagawa, H. Nakagomi, Y. Nakamiya, K.R. Nakamura, T. Nakamura, K. Nakano, S. Nam, C. Nattrass, A. Nederlof, P.K. Netrakanti, J. Newby, M. Nguyen, M. Nihashi, T. Niida, S. Nishimura, B.E. Norman, R. Nouicer, T. Novák, N. Novitzky, R. Novotny, A. Nukariya, A.S. Nyanin, J. Nystrand, C. Oakley, H. Obayashi, E. O'Brien, S.X. Oda, C.A. Ogilvie, H. Ohnishi, H. Oide, I.D. Ojha, M. Oka, K. Okada, O.O. Omiwade, Y. Onuki, J.D. Orjuela Koop, J.D. Osborn, A. Oskarsson, I. Otterlund, G.J. Ottino, M. Ouchida, K. Ozawa, R. Pak, D. Pal, A.P.T. Palounek, V. Pantuev, V. Papavassiliou, B.H. Park, I.H. Park, J. Park, J.S. Park, S. Park, S.K. Park, W.J. Park, S.F. Pate, L. Patel, M. Patel, H. Pei, J.-C. Peng, W. Peng, H. Pereira, D.V. Perepelitsa, G.D.N. Perera, V. Peresedov, D.Yu. Peressounko, C.E. PerezLara, J. Perry, R. Petti, M. Phipps, C. Pinkenburg, R. Pinson, R.P. Pisani, M. Proissl, A. Pun, M.L. Purschke, A.K. Purwar, H. Qu, P.V. Radzevich, J. Rak, A. Rakotozafindrabe, B.J. Ramson, I. Ravinovich, K.F. Read, S. Rembeczki, M. Reuter, K. Reygers, D. Reynolds, V. Riabov, Y. Riabov, E. Richardson, D. Richford, T. Rinn, N. Riveli, D. Roach, G. Roche, S.D. Rolnick, A. Romana, M. Rosati, C.A. Rosen, S.S.E. Rosendahl, P. Rosnet, Z. Rowan, J.G. Rubin, P. Rukoyatkin, J. Runchey, P. Ružička, V.L. Rykov, M.S. Ryu, S.S. Ryu, A.S. Safonov, B. Sahlmueller, N. Saito, T. Sakaguchi, S. Sakai, K. Sakashita, H. Sakata, H. Sako, V. Samsonov, M. Sano, S. Sano, M. Sarsour, H.D. Sato, K. Sato, S. Sato, T. Sato, M. Savastio, S. Sawada, B. Schaefer, B.K. Schmoll, K. Sedgwick, J. Seele, R. Seidl, Y. Sekiguchi, A.Yu. Semenov, V. Semenov, A. Sen, R. Seto, P. Sett, A. Sexton, D. Sharma, A. Shaver, T.K. Shea, I. Shein, A. Shevel, T.-A. Shibata, K. Shigaki, H.H. Shim, M. Shimomura, T. Shioya, T. Shohjoh, K. Shoji, P. Shukla, A. Sickles, C.L. Silva, D. Silvermyr, C. Silvestre, K.S. Sim, B.K. Singh, C.P. Singh, V. Singh, M.J. Skoby, M. Skolnik, S. Skutnik, M. Slunečka, K.L. Smith, W.C. Smith, M. Snowball, T. Sodre, S. Solano, A. Soldatov, R.A. Soltz, W.E. Sondheim, S.P. Sorensen, I.V. Sourikova, N.A. Sparks, F. Staley, P.W. Stankus, P. Steinberg, E. Stenlund, M. Stepanov, A. Ster, S.P. Stoll, M.R. Stone, T. Sugitate, C. Suire, A. Sukhanov, J.P. Sullivan, T. Sumita, J. Sun, S. Syed, J. Sziklai, T. Tabaru, S. Takagi, E.M. Takagui, A. Takahara, A. Takeda, A. Taketani, R. Tanabe, K.H. Tanaka, Y. Tanaka, S. Taneja, K. Tanida, M.J. Tannenbaum, S. Tarafdar, A. Taranenko, P. Tarján, G. Tarnai, E. Tennant, H. Themann, D. Thomas, T.L. Thomas, R. Tieulent, A. Timilsina, T. Todoroki, M. Togawa, A. Toia, J. Tojo, L. Tomášek, M. Tomášek, Y. Tomita, H. Torii, C.L. Towell, M. Towell, R. Towell, R.S. Towell, V.-N. Tram, I. Tserruya, Y. Tsuchimoto, T. Tsuji, S.K. Tuli, H. Tydesjö, N. Tyurin, Y. Ueda, B. Ujvari, K. Utsunomiya, C. Vale, H. Valle, H.W. van Hecke, M. Vargyas, S. Vazquez-Carson, E. Vazquez-Zambrano, A. Veicht, J. Velkovska, R. Vértesi, A.A. Vinogradov, M. Virius, B. Voas, A. Vossen, V. Vrba, N. Vukman, E. Vznuzdaev, M. Wagner, D. Walker, X.R. Wang, Z. Wang, D. Watanabe, K. Watanabe, Y. Watanabe, Y.S. Watanabe, F. Wei, R. Wei, J. Wessels, S. Whitaker, A.S. White, S.N. White, N. Willis, D. Winter, S. Wolin, C.P. Wong, J.P. Wood, C.L. Woody, R.M. Wright, M. Wysocki, B. Xia, W. Xie, C. Xu, Q. Xu, L. Xue, S. Yalcin, Y.L. Yamaguchi, H. Yamamoto, K. Yamaura, R. Yang, A. Yanovich, Z. Yasin, P. Yin, J. Ying, S. Yokkaichi, J.H. Yoo, J.S. Yoo, I. Yoon, Z. You, G.R. Young, I. Younus, H. Yu, I.E. Yushmanov, W.A. Zajc, O. Zaudtke, A. Zelenski, C. Zhang, S. Zharko, S. Zhou, J. Zimamyi, L. Zolin, and L. Zou

Subjects
Nuclear and High Energy Physics
Published
2019

61. Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial.

Author

Ashish Narayan Masurekar, Catriona A Parker, Milensu Shanyinde, Anthony V Moorman, Jeremy P Hancock, Rosemary Sutton, Philip J Ancliff, Mary Morgan, Nicholas J Goulden, Chris Fraser, Peter M Hoogerbrugge, Tamas Revesz, Philip J Darbyshire, Shekhar Krishnan, Sharon B Love, and Vaskar Saha

Subjects
Medicine, Science
Abstract

The outcomes of Central Nervous System (CNS) relapses in children with acute lymphoblastic leukaemia (ALL) treated in the ALL R3 trial, between January 2003 and March 2011 were analysed. Patients were risk stratified, to receive a matched donor allogeneic transplant or fractionated cranial irradiation with continued treatment for two years. A randomisation of Idarubicin with Mitoxantrone closed in December 2007 in favour of Mitoxantrone. The estimated 3-year progression free survival for combined and isolated CNS disease were 40.6% (25·1, 55·6) and 38.0% (26.2, 49.7) respectively. Univariate analysis showed a significantly better survival for age

Published
2014
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62. Simple Amides and Amines for the Synergistic Recovery of Rhodium from Hydrochloric Acid by Solvent Extraction

Author

Andrew I. Carrick, Jane Patrick, Emma R. Schofield, Jason B. Love, Carole A. Morrison, Gary S. Nichol, Alexander Bouch, and Euan D. Doidge

Subjects
hydrometallurgy, Chemistry, Multidisciplinary, PLATINUM-GROUP METALS, synergistic, chemistry.chemical_element, Hot Paper, Hydrochloric acid, recycling, 010402 general chemistry, PT(IV), 01 natural sciences, Catalysis, Rhodium, Metal, MEDIA, chemistry.chemical_compound, Amide, GOLD, Amines, SPECIATION, Science & Technology, Full Paper, 010405 organic chemistry, Organic Chemistry, Extraction (chemistry), Aqueous two-phase system, SELECTIVE RECOVERY, RH(III), General Chemistry, Full Papers, sustainability, Enol, Combinatorial chemistry, Amides, 0104 chemical sciences, Chemistry, chemistry, visual_art, Reagent, Physical Sciences, visual_art.visual_art_medium, SEPARATION, Solvents, CHLORIDE, COMPLEXES, Hydrochloric Acid, 03 Chemical Sciences, critical metals
Abstract

The separation and isolation of many of the platinum group metals (PGMs) is currently achieved commercially using solvent extraction processes. The extraction of rhodium is problematic however, as a variety of complexes of the form [RhCln(H2O)6‐n](n−3)− are found in hydrochloric acid, making it difficult to design a reagent that can extract all the rhodium. In this work, the synergistic combination of a primary amine (2‐ethylhexylamine, LA) with a primary amide (3,5,5‐trimethylhexanamide, L1) is shown to extract over 85 % of rhodium from 4 M hydrochloric acid. Two rhodium complexes are shown to reside in the organic phase, the ion‐pair [HLA]3[RhCl6] and the amide complex [HLA]2[RhCl5(L1)]; in the latter complex, the amide is tautomerized to its enol form and coordinated to the rhodium centre through the nitrogen atom. This insight highlights the need for ligands that target specific metal complexes in the aqueous phase and provides an efficient synergistic solution for the solvent extraction of rhodium., A synergistic combination of a simple primary amine (LA) and a simple primary amide (L1) is shown to extract rhodium from hydrochloric acid. A range of experimental and computational techniques are used to elucidate the structures of two different complexes in the organic phase; the ion‐pair [HLA]3[RhCl6] and the amide complex [HLA]2[RhCl5(L1)]. In the latter complex, the amide is tautomerized to its enol form and coordinated through the nitrogen atom.

Published
2021

63. Interpersonal relationships drive successful team science: an exemplary case-based study

Author

Sue VandeWoude, Ellen R. Fisher, Bailey K. Fosdick, Hannah B. Love, Kevin R. Crooks, and Jennifer E. Cross

Subjects
030213 general clinical medicine, Social Sciences, Participant observation, Terminology, 03 medical and health sciences, 0302 clinical medicine, AZ20-999, Social network analysis, General Psychology, 030304 developmental biology, 0303 health sciences, Social network, Scientific progress, business.industry, General Arts and Humanities, General Social Sciences, General Business, Management and Accounting, Focus group, Interactional expertise, History of scholarship and learning. The humanities, Engineering ethics, Psychology, business, General Economics, Econometrics and Finance, Systemic problem
Abstract

Scientists are increasingly charged with solving complex societal, health, and environmental problems. These systemic problems require teams of expert scientists to tackle research questions through collaboration, coordination, creation of shared terminology, and complex social and intellectual processes. Despite the essential need for such interdisciplinary interactions, little research has examined the impact of scientific team support measures like training, facilitation, team building, and expertise. The literature is clear that solving complex problems requires more than contributory expertise, expertise required to contribute to a field or discipline. It also requires interactional expertise, socialised knowledge that includes socialisation into the practices of an expert group. These forms of expertise are often tacit and therefore difficult to access, and studies about how they are intertwined are nearly non-existent. Most of the published work in this area utilises archival data analysis, not individual team behaviour and assessment. This study addresses the call of numerous studies to use mixed-methods and social network analysis to investigate scientific team formation and success. This longitudinal case-based study evaluates the following question: How are scientific productivity, advice, and mentoring networks intertwined on a successful interdisciplinary scientific team? This study used applied social network surveys, participant observation, focus groups, interviews, and historical social network data to assess this specific team and assessed processes and practices to train new scientists over a 15-year period. Four major implications arose from our analysis: (1) interactional expertise and contributory expertise are intertwined in the process of scientific discovery; (2) team size and interdisciplinary knowledge effectively and efficiently train early career scientists; (3) integration of teaching/training, research/discovery, and extension/engagement enhances outcomes; and, (4) interdisciplinary scientific progress benefits significantly when interpersonal relationships among scientists from diverse disciplines are formed. This case-based study increases understanding of the development and processes of an exemplary team and provides valuable insights about interactions that enhance scientific expertise to train interdisciplinary scientists.

Published
2021

64. An economic approach to produce iron doped TiO2 nanorods from ilmenite for photocatalytic applications

Author

Xianfeng Fan, Jason B. Love, Jialin Yu, and Shibo Shao

Subjects
Materials science, Dopant, Mechanical Engineering, Metals and Alloys, chemistry.chemical_element, 02 engineering and technology, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Nanomaterials, Titanium oxide, chemistry.chemical_compound, chemistry, Chemical engineering, Mechanics of Materials, Titanium dioxide, Materials Chemistry, Photocatalysis, engineering, Nanorod, 0210 nano-technology, Ilmenite, Titanium
Abstract

Titanium dioxide (TiO2) is one of the most promising photocatalytic materials, but its practical applications are always limited since it could only be excited in the UV range and has low photocatalytic efficiency due to its wide band gap and fast recombination rate. To overcome these problems, transition metals have been used as dopants to improve the photocatalytic performance of titanium dioxide. However, previous investigations have shown that doping by hydrothermal, sol-gel or other synthetic pathways in the catalyst synthesis are difficult to scale-up for mass production. In this work, ilmenite (FeTiO3), the most abundant titanium mineral, was used as the raw material to produce iron-doped titanium oxide nanorods by an economic acid treatment approach. Compared with commercial titanium oxide nanomaterials, the photocatalytic performance for Rhodamine B (RHB) degradation of as-prepared materials were significantly improved and could be activated by visible light irradiation. The results from characterization also show the band gap and recombination rate are modified by the iron dopant. This work provides a possible method which can significantly reduce the cost for producing iron doped TiO2 in high yield for photocatalytic applications.

Published
2021

65. The Loyal Wife

Author

B. Love and B. Love

Abstract

An emotionally charged psychological thriller that will leave fans breathless as they bear witness to the lengths a wife will go to honor her vows. An addictive page turner for fans of twisty plots in the same vein of Colleen Hoover's Verity.Perfect wife… Perfect life… until you can't remember either. The moment Dante Williams wakes up on the side of the road, unsure of where he is or who he is, his life changes for the worse. After a brief stay in the hospital, Dante is released to the care of his loving wife, Sade. Sade is beautiful, successful, and loyal. So loyal, she devotes herself to Dante indefinitely, hoping this will help him appreciate what he has—his life and his wife. While seemingly having it all, their perfect marriage isn't enough to keep Dante from digging up the past in hopes of recovering his memory. It isn't long before he begins questioning Sade's behavior and intentions. Once secrets start to unravel, Dante is left more confused than the day following the accident. When Dante discovers evidence of something more sinister at play, he prepares to end his marriage but learns quickly that Sade meant every word in her vows and plans to honor them, until death.

Published
2024

66. Synthesis and complexes of a constrained-cavity Schiff-base dipyrrin macrocycle

Author

Jason B. Love and Karlotta van Rees

Subjects
chemistry.chemical_classification, Schiff base, chemistry.chemical_element, Salt (chemistry), law.invention, Inorganic Chemistry, chemistry.chemical_compound, Elimination reaction, chemistry, law, Polymer chemistry, Lithium, Crystallization, Spectroscopy
Abstract

A new constrained-cavity [1 + 1] Schiff-base dipyrrin macrocycle comprising an N4donor-pocket has been synthesised by spontaneous oxidation andin situcrystallisation. Access to Fe(ii) and Zn(ii) complexes is achieved by salt elimination reactions of the lithium salt. All compounds have been characterised by NMR and UV-vis spectroscopy, X-ray crystallography, and DFT analysis.

Published
2021

67. Inflammatory Disorders: Psoriasis, Lichen Planus, Pityriasis Rosea, and Sarcoidosis

Author

Callie R. Mitchell and Porcia B. Love

Subjects
medicine.medical_specialty, integumentary system, Erythema, Lichen planus pigmentosus, business.industry, medicine.disease, Hyperpigmentation, Dermatology, stomatognathic diseases, medicine.anatomical_structure, stomatognathic system, Psoriasis, Scalp, Pityriasis rosea, medicine, Lichen planus actinicus, Sarcoidosis, medicine.symptom, skin and connective tissue diseases, business
Abstract

Inflammatory skin conditions are common in all ages and races. These disorders can be disfiguring and cause great discomfort, leading to a negative impact on the patient’s quality of life. Inflammatory conditions can present atypically in skin of color. In darker skin, psoriasis plaques may be violaceous with gray scale, and erythema is sometimes difficult to appreciate. In skin of color, the classic purple color of lichen planus may be black, gray, brown, or violaceous. Lichen planus actinicus and lichen planus pigmentosus are variants that are more common in darker skin. Atypical forms of pityriasis rosea present more commonly in skin of color, including papular pityriasis rosea, and involvement of the face, scalp, and mouth. There is a higher incidence of sarcoidosis in African Americans compared to Caucasians, and African Americans seemed to be diagnosed at an earlier age and have more severe disease. If untreated, inflammatory conditions in patients with skin of color can lead to post-inflammatory hyperpigmentation, which can be very difficult to treat.

Published
2021

68. Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

Author

David M. Levine, Tania Noder, Jakob R. Izbicki, Hauke Lang, Marino Venerito, Hugh Barr, Laura Chegwidden, Timo Hess, Horst Neuhaus, Kirsten B. Moysich, David C. Whiteman, Christine B. Ambrosone, Peter H. Watson, Douglas A. Corley, Harvey A. Risch, Jessica Becker, Rebecca Harrison, Sharon B. Love, James Y. Dai, Arnulf H. Hölscher, Jesper Lagergren, Andrea May, Leslie Bernstein, Anna H. Wu, Thomas Rösch, Geoffrey Liu, Markus M. Nöthen, Paul Moayyedi, Katja Ott, Mario Anders, Michael Vieth, Stuart MacGregor, Johannes Schumacher, Oliver Pech, Qianchuan He, Brigitte Schumacher, Rupert Mayershofer, Lothar Veits, Wong Ho Chow, Matthew F. Buas, Lesley A. Anderson, Puya Gharahkhani, John deCaestecker, Margaret M. Madeleine, Josef Weismüller, Claire Palles, Lynn Onstad, Nicholas J. Shaheen, Susanne Moebus, Christian Gerges, Marilie D. Gammon, Christian Ell, Yogesh K. Vashist, Anne C. Böhmer, Laura J. Hardie, Ines Gockel, Thomas Schmidt, David MacDonald, Stephen Attwood, Shruti G. Dighe, Hendrik Manner, Jianhong Chen, Nicole Kreuser, Dietmar Lorenz, Janusz Jankowski, Hans Prenen, Prasad G. Iyer, Weimin Ye, Michael Knapp, Li Yan, Thomas L. Vaughan, Ian Tomlinson, and Claudia Schmidt

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Medizin, Single-nucleotide polymorphism, Genome-wide association study, Biology, Adenocarcinoma, Polymorphism, Single Nucleotide, Receptor, IGF Type 1, 03 medical and health sciences, Barrett Esophagus, 0302 clinical medicine, Risk Factors, Somatomedins, Internal medicine, Genetic variation, medicine, Biomarkers, Tumor, SNP, Humans, Genetic Predisposition to Disease, Risk factor, Germ-Line Mutation, Cancer Biomarkers and Molecular Epidemiology, Insulin-like growth factor 1 receptor, Genetic association, Aged, General Medicine, Middle Aged, medicine.disease, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, 030220 oncology & carcinogenesis, Barrett's esophagus, Female, Human medicine, Carrier Proteins, Genome-Wide Association Study, Signal Transduction
Abstract

Contains fulltext : 235640.pdf (Publisher’s version ) (Closed access) Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analysis was employed to evaluate pathway-level and gene-level associations with BE/EAC, using genotypes for 270 single-nucleotide polymorphisms (SNPs) in or near 12 IGF-related genes, ascertained from 3295 BE cases, 2515 EAC cases and 3207 controls in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) GWAS. Gene-level signals were assessed using Multi-marker Analysis of GenoMic Annotation (MAGMA) and SNP summary statistics from BEACON and an expanded GWAS meta-analysis (6167 BE cases, 4112 EAC cases, 17 159 controls). Global variation in the IGF pathway was associated with risk of BE (P = 0.0015). Gene-level associations with BE were observed for GHR (growth hormone receptor; P = 0.00046, false discovery rate q = 0.0056) and IGF1R (IGF1 receptor; P = 0.0090, q = 0.0542). These gene-level signals remained significant at q < 0.1 when assessed using data from the largest available BE/EAC GWAS meta-analysis. No significant associations were observed for EAC. This study represents the most comprehensive evaluation to date of inherited genetic variation in the IGF pathway and BE/EAC risk, providing novel evidence that variation in two genes encoding cell-surface receptors, GHR and IGF1R, may influence risk of BE.

Published
2021

69. Water promoted photocatalytic Cβ-O bonds hydrogenolysis in lignin model compounds and lignin biomass conversion to aromatic monomers

Author

Shibo Shao, Ke Wang, Jason B. Love, Jialin Yu, Shangfeng Du, Zongyang Yue, and Xianfeng Fan

Subjects
Lignin valorization, General Chemical Engineering, Biomass utilization, Environmental Chemistry, C−O bond cleavage, General Chemistry, Photocatalysis, Industrial and Manufacturing Engineering
Abstract

Photocatalysis has proved its potential in cleaving the Cβ-O linkages between the natural aromatic units in lignin biomass and converting abundant lignin biomass to valuable aromatic monomer products. However, the slow reaction rate and low selectivity for aromatic monomers still hinder its future industrial implementation. To address these challenges in photocatalytic Cβ-O bond fragmentation, a Zn/S rich phase zinc indium sulfide photocatalyst was developed to promote hydrogenolysis of Cβ-O linkages in lignin. In this work, water is for the first time, used as the hydrogen donor and can significantly promote the photocatalytic process by eliminating the limitation of protons supply. The reaction selectivity for aromatic monomers increased by 170% and PP-ol conversion rate raised by 58% comparing to the reaction condition without water. Notably, complete conversion of lignin model compounds with an expectational improved reaction rate and over 90% selectivity for aromatic monomers have been achieved in this study. The isotopic labeling experiments and kinetic isotope effects (KIE) measurements also indicate that the dissociation of the O–H bond in water which provides protons to the Cβ-O bond hydrogenolysis process is a critical step to this reaction. Mechanistic studies reveal that the dehydrogenated radical intermediates are initially generated by the oxidation of photogenerated holes, and the protons generated from photocatalytic water splitting are superior in facilitating the subsequently hydrogenolysis process of Cβ-O bonds. This study provides a new and effective strategy to promote the cleavage of Cβ-O linkages and is helpful for the future development of photocatalytic lignin valorization.

Published
2022

70. Measurement of jet-medium interactions via direct photon-hadron correlations in Au+Au and d+Au collisions at sNN=200 GeV

Author

Atsushi Takahara, K. A. Drees, A. V. Kazantsev, C. M. Camacho, Gary Grim, R. S. Towell, Prashant Shukla, Dmitry Blau, K. V. Dharmawardane, L. Tomášek, S. F. Pate, Ke. Nakamura, P. Mikeš, Y. Nakamiya, D. Lynch, H. Al-Bataineh, J. A. Key, J. Klatsky, P. Tarján, G. Baksay, J. B. Choi, L. Patel, I. Tserruya, S. Tarafdar, J. Hanks, S. Motschwiller, D. Ivanishchev, B. Voas, V. Papavassiliou, R. S. Hollis, C. E. Perezlara, E. P. Hartouni, V. Singh, H. Asano, T. C. Awes, E. Vazquez-Zambrano, E. J. Desmond, A. Hodges, Kyoichiro Ozawa, T. Liška, Jun Kikuchi, Z. Sun, A. Yu. Semenov, M. Rosati, D. Kawall, Yuhei Morino, A. Nederlof, T. Murakami, E. M. Takagui, Eva Haslum, K. O. Eyser, Y. Onuki, Y. Imazu, Shoichi Hasegawa, S. Choi, T. Niida, S. P. Stoll, A. Sen, V. S. Pantuev, M. Sano, A. Lebedev, A. Rakotozafindrabe, Jan Rak, R. Lacey, M. Sarsour, Mate Csanad, Tomoya Tsuji, M. Mendoza, S. N. White, L. Zou, J. G. Lajoie, Deepa Thomas, K. Tanida, J. Hamblen, M. Nihashi, M. Skolnik, S. I. Morrow, S. Baumgart, S. Bathe, R. Granier de Cassagnac, Charles Maguire, Kenjiro Miki, Bruno Lenzi, N. Crossette, R. P. Pisani, Tamás Csörgő, U. Acharya, M. McCumber, P. Garg, S. Sawada, Masamichi Ishihara, A. Glenn, P. V. Radzevich, A. Ster, Y. Fukao, B. Azmoun, Y. J. Mao, M. Kawashima, Hiromi Iinuma, T. Hester, E. Kistenev, B. Ujvari, M. Kasai, N. A. Sparks, J. Ying, J. Runchey, A. Isinhue, N. Grau, H. Qu, M. Leitgab, Shuo Han, Eunja Kim, Motoi Inaba, J. C. Hill, Minghui Liu, R. M. Wright, Sung Keun Park, C. Baumann, Zvi Hirsh Citron, S. Yokkaichi, P. Lichtenwalner, Kensuke Homma, E. Richardson, Senta Greene, P. Rosnet, K. Fujiwara, H. Obayashi, Y. Tsuchimoto, A. Berdnikov, J. Newby, Hideki Hamagaki, W. Fan, K. Aoki, M. Vargyas, G. David, T. Todoroki, Y. Iwanaga, K. Das, K. Nakano, M. Heffner, Kenneth Francis Read, N. N. Ajitanand, K. Okada, Gerd Joachim Kunde, D. Richford, S. Taneja, H. Van Hecke, K. B. Kim, J. Alexander, Y. L. Yamaguchi, Frank Ellinghaus, B. Bassalleck, K. Karatsu, K. I. Hahn, B. Sahlmueller, H. A. Gustafsson, A. Král, S. Kametani, H. En'yo, Alexander Milov, I. Nakagawa, R. Luechtenborg, A. A. Vinogradov, S. P. Whitaker, A. Caringi, M. J. Leitch, I. Shein, E. Leitner, M. Patel, N. Ramasubramanian, T. Ichihara, Y. Ikeda, Takahiro Nakamura, M. Konno, H. Pei, Y. Hori, Anne Marie Sickles, H. Themann, K. Gainey, Young-Ki Kim, T. Engelmore, N. Novitzky, O. Drapier, C. P. Singh, K. Sedgwick, J. Midori, I. Younus, V. Borisov, Peter Christiansen, J. S. Bok, B. M. Johnson, P. Kline, K. S. Lee, A. Dion, E. O'Brien, Paul Constantin, M. Grosse Perdekamp, J. Huang, Bum-Hoon Lee, E. J. Mannel, T. Rinn, J. T. Mitchell, R. Seidl, G. R. Young, I. E. Yushmanov, A. Taranenko, W. E. Sondheim, E. R. Kinney, D. P. Morrison, Vladislav Manko, S. Campbell, B. H. Kang, S. Wolin, B. Blankenship, Susumu Oda, R. Akimoto, Jiangyong Jia, Y. Goto, N. Kamihara, T. Horaguchi, Mihael Makek, X. Jiang, C. Pinkenburg, N. A. Lewis, M. K. Dayananda, Aram Kim, F. Matathias, T. W. Jones, Filip Krizek, H. J. Kim, Vladimir Samsonov, Tatsuya Chujo, K. Dehmelt, S. R. P. Mohapatra, C. Zhang, A. Durum, Dillon Scott Fitzgerald, Iu. Mitrankov, T. Kempel, V. Canoa Roman, P. Chung, S. K. Park, P. Liebing, M. Wysocki, Jen-Chieh Peng, P. Ružička, A. Kiss, Byoungchoo Park, A. Isupov, B. Bannier, K. S. Sim, Christine Nattrass, A. Garishvili, J. Imrek, Y. Gu, K. Boyle, P. A. Rukoyatkin, M. Stepanov, G. Roche, P. Steinberg, D. Kleinjan, M. S. Ryu, D. Reynolds, S. Belikov, K. S. Joo, Torsten Dahms, K. Yamaura, M. Potekhin, C. Oakley, A. Drees, Henner Buesching, R. Yang, I. V. Sourikova, C. Vale, J. Sziklai, Steve Edwards, Yu. Efremenko, D. K. Mishra, Inkyu Park, A. Meles, R. A. Soltz, Ajit Kumar Mohanty, T. A. Shibata, T. Sato, Xiong Wang, B. Love, Z. Conesa del Valle, M. Naglis, T. Majoros, K. L. Smith, Takahiro Fusayasu, J. H. Kang, Y. Miyachi, Dong Jo Kim, Alexander Malakhov, K. Imai, M. Proissl, J. S. Haggerty, S. R. Lee, C. L. Silva, D. H. Kim, Brian Cole, M. S. Daugherity, Alberica Toia, D. Isenhower, T. Moon, Viktor Riabov, Z. Ji, D. Winter, Hongfang Liu, D. E. Fields, N. Apadula, X. Gong, M. Chiu, D. Yu Peressounko, Dennis Perepelitsa, Taku Gunji, H. Gong, F. Kajihara, A. Veicht, A. Basye, A. Vossen, C. A. Ogilvie, Y. Tanaka, Jihyun Bhom, Qiao Xu, Y. J. Kwon, J. M. Durham, D. Silvermyr, Eun Joo Kim, I. Garishvili, O. Dietzsch, F. Wei, Ryugo S. Hayano, A. K. Purwar, Ferdinando Giordano, S. Butsyk, Y. Komatsu, Aaron Angerami, S. Zhou, E. T. Atomssa, Yoshifumi Ueda, J. H. Do, R. Esha, R. Petti, Kisung Lee, T. K. Hemmick, Bhawani Singh, Yasuo Miake, Y. Riabov, M. Javani, S. D. Rolnick, H. Valle, Susumu Sato, B. Mulilo, Tomofumi Nagae, J. L. Nagle, Yanjun Wu, K. Watanabe, Dipanwita Dutta, Nagahiro Saito, C. P. Wong, N. Riveli, S. Esumi, Y. S. Lai, L. A. Linden Levy, D. Sharma, C. Gal, J. S. Kang, R. Ichimiya, L. S. Zolin, S. W. Nam, W. J. Park, K. DeBlasio, Christopher Rosen, L. Kochenda, M. Issah, P. Castera, Kenta Shigaki, H. J. Moon, L. Baksay, M. Nguyen, M. Connors, W. A. Zajc, Julia Velkovska, A. Khatiwada, Y. Zhai, A. Iordanova, K. Shoji, J. Ide, J. Murata, V. Baublis, Yongsun Kim, Don McGlinchey, K. Sakashita, A. G. Litvinenko, D. Firak, Martin Purschke, C. A. Aidala, W. Peng, P. W. Stankus, B. Komkov, A. Denisov, Yuki Watanabe, V. Cianciolo, D. Kotov, L. Guo, Alexei Khanzadeev, Agneta Oskarsson, D. Kincses, Shinichi Masumoto, A. Yanovich, L. Bichon, E. Stenlund, D. Kotchetkov, S. Huang, A. S. Nyanin, M. Larionova, Animesh Datta, Sergey Fokin, C. Y. Chi, Y. Berdnikov, M. Moskowitz, S. S.E. Rosendahl, Rachid Nouicer, Tsutomu Mibe, M. A. L. Leite, G. Bunce, J.-G. Park, A. N. Zelenski, Y. Watanabe, S. H. Lee, Z. Fraenkel, N. Cronin, C. Silvestre, Yasutada Akiba, C. McKinney, M. Mishra, S. Nagamiya, R. K. Choudhury, D. Hornback, D. Jouan, Vaclav Vrba, Klaus Johannes Reygers, Astrid Morreale, Rui Wei, M. Kurosawa, S. H. Lim, S. Solano, T. V. Moukhanova, R. Belmont, B. Meredith, D. Larionova, Marisilvia Donadelli, J. S. Kapustinsky, A. Adare, V. Babintsev, B. Lewis, V. Bumazhnov, D. Black, M. Tomášek, John Wood, J. P. Wessels, J. Seele, G. S. Kyle, Alice Mignerey, L. D'Orazio, S. Miyasaka, A. Franz, M. Ouchida, S. Hayashi, N. Means, J. Jin, Byung-Sik Hong, A. Bazilevsky, H. A. Torii, B. Kurgyis, Toru Sugitate, Pawan Kumar Netrakanti, X. Sun, D. M. Lee, A. Kozlov, R. Seto, K. Kiriluk, François Fleuret, Takao Sakaguchi, R. Tanabe, Jason Kamin, B. Fadem, A. D. Frawley, X. He, J. Sun, Y. Aramaki, V. Peresedov, Robert Vertesi, Barbara Jacak, Rushan Han, Wesley James Metzger, W. Holzmann, J. Koster, Maya Hachiya Shimomura, Vardan Khachatryan, Y. I. Makdisi, H. Masui, A. A. Bickley, C. L. Woody, A. Mwai, Sándor Lökös, K. N. Barish, S. Zharko, S. Sano, M. L. Brooks, M. J. Tannenbaum, E. Tennant, S. Rembeczki, S. Dairaku, M. Virius, Manabu Togawa, C. H. Chen, A. Manion, I. Ravinovich, M. Bai, E. C. Aschenauer, J. D. Osborn, Inseok Yoon, Zhiying You, R. Bennett, T. L.T. Thomas, M. Finger, J. E. Frantz, Jongmin Lee, A. Enokizono, P. K. Khandai, A. Taketani, Priyanka Sett, D. S. Jumper, Makoto Oka, K. B. Lee, S. Nelson, L. Ding, D. Roach, K. M. Kijima, A. Pun, K. Hashimoto, Xingguo Li, M. Gonin, H. Al-Ta'Ani, A. Sukhanov, K. Kurita, H. Pereira, C. O. Kim, R. Pak, S. Kaneti, S. P. Sorensen, O. Chvala, Seong H. Kim, T. Hachiya, A. Kravitz, S. V. Afanasiev, H. Sako, M. I. Nagy, D. Watanabe, Marcus Hohlmann, M. D. Malik, E. Vznuzdaev, J. Bryslawskyj, I. Danchev, Beomkyu Kim, Wei Xie, A. Deshpande, I. J. Choi, B. Xia, Tadaaki Isobe, M. Slunečka, P. L. McGaughey, Ralf Peter Averbeck, and A. Nukariya

Subjects
Quark, Physics, Photon, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Nuclear Theory, Hadron, Nuclear matter, 01 natural sciences, Nuclear physics, Deuterium, Fragmentation (mass spectrometry), 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics
Abstract

We present direct photon-hadron correlations in 200 GeV/A Au+Au, d+Au, and p+p collisions, for direct photon pT from 5–12 GeV/c, collected by the PHENIX Collaboration in the years from 2006 to 2011. We observe no significant modification of jet fragmentation in d+Au collisions, indicating that cold nuclear matter effects are small or absent. Hadrons carrying a large fraction of the quark's momentum are suppressed in Au+Au compared to p+p and d+Au. As the momentum fraction decreases, the yield of hadrons in Au+Au increases to an excess over the yield in p+p collisions. The excess is at large angles and at low hadron pT and is most pronounced for hadrons associated with lower momentum direct photons. Comparison to theoretical calculations suggests that the hadron excess arises from medium response to energy deposited by jets.

Published
2020

71. Synthesis and structures of anionic rhenium polyhydride complexes of boron–hydride ligands and their application in catalysis

Author

Stephen P. Thomas, Liam J. Donnelly, Simon Parsons, Jason B. Love, and Carole A. Morrison

Subjects
Perrhenate, Chemistry, Pinacol, Hydride, chemistry.chemical_element, Regioselectivity, General Chemistry, Nuclear magnetic resonance spectroscopy, Borane, Rhenium, Borylation, chemistry.chemical_compound, Polymer chemistry
Abstract

The rhenium complex, [K(DME)(18-c-6)][ReH4(Bpin)(η2-HBpin)(κ2-H2Bpin)] 1, comprising hydride and boron ligands only, has been synthesized by exhaustive deoxygenation of the commercially available perrhenate anion (ReO4−) with pinacol borane (HBpin). The structure of 1 was analysed by X-ray crystallography, NMR spectroscopy, and DFT calculations. While no hydrides were located in the X-ray crystal structure, it revealed a trigonal arrangement of pinacol boron ligands. Variable-temperature NMR spectroscopy supported the presence of seven hydride ligands but further insight was hindered by the fluxionality of both hydride and boron ligands at low temperature. Further evaluation of the structure by Ab Initio Random Structure Searching (AIRSS) identified the presence of hydride, boryl, σ-borane, and dihydroborate ligands. This complex, either isolated or prepared in situ, is a catalyst for the 1,4-hydroboration of N-heteroaromatic substrates under simple operating procedures. It also acts as a reagent for the stoichiometric C–H borylation of toluene, displaying high meta regioselectivity in the borylated products. Reaction of 1 with 9-BBN resulted in HBpin substitution to form the new anionic tetra(dihydroborate) complex [K(DME)(18-c-6)][Re(κ2-H-9-BBN)4] 4 for which the hydride positions were clearly identified by X-ray crystallography. The method used to generate these isolable yet reactive boron–hydride complexes is direct and straightforward and has potential utility for the exploitation of other metal oxo compounds in operationally simple catalytic reactions., Exhaustive deoxygenation of perrhenate by pinacol borane forms a new Re anion of boron and hydride ligands only that undergoes borane ligand exchange, stoichiometric C–H boration, and catalytic pyridine hydroboration.

Published
2020

72. Reducing the Competition: A Dual-Purpose Ionic Liquid for the Extraction of Gallium from Iron Chloride Solutions

Author

Carole A. Morrison, Bryne T. Ngwenya, Luke M. M. Kinsman, and Jason B. Love

Subjects
inorganic chemicals, Magnetic Resonance Spectroscopy, Iron, Inorganic chemistry, Iodide, Pharmaceutical Science, chemistry.chemical_element, Ionic Liquids, Gallium, recycling, Chloride, Ferric Compounds, Analytical Chemistry, UV-Vis spectrophotometry, lcsh:QD241-441, chemistry.chemical_compound, NMR spectroscopy, Chlorides, lcsh:Organic chemistry, Drug Discovery, medicine, Physical and Theoretical Chemistry, Solvent extraction, ionic liquid, chemistry.chemical_classification, Communication, Organic Chemistry, Extraction (chemistry), Nuclear magnetic resonance spectroscopy, sustainability, solvent extraction, Solutions, chemistry, Chemistry (miscellaneous), Ionic liquid, secondary resources, Molecular Medicine, Spectrophotometry, Ultraviolet, Counterion, medicine.drug
Abstract

The separation of gallium from iron by solvent extraction from chloride media is challenging because the anionic chloridometalates, FeCl4− and GaCl4−, display similar chemical properties. However, we report here that the selective separation of gallium from iron in HCl solution can be achieved using the dual-purpose ionic liquid methyltrioctylammonium iodide in a solvent extraction process. In this case, the reduction of Fe3+ to Fe2+ by the iodide counterion was found to inhibit Fe transport, facilitating quantitative Ga extraction by the ionic liquid with minimal Fe extraction from 2 M HCl.

Published
2020

73. Erratum: Evolution of π0 Suppression in Au+Au Collisions from sNN=39 to 200 GeV [Phys. Rev. Lett. 109 , 152301 (2012)]

Author

X. Jiang, H. Pei, S. Taneja, K. Karatsu, H. J. Kim, Y. Hori, Anne Marie Sickles, H. Themann, K. Gainey, M. S. Daugherity, Y. L. Yamaguchi, Y. Komatsu, Mate Csanad, I. Ravinovich, Marisilvia Donadelli, V. Bumazhnov, M. Nihashi, B. Komkov, K. B. Lee, I. Younus, Peter Christiansen, N. N. Ajitanand, X. He, Y. Aramaki, V. Peresedov, Robert Vertesi, K. S. Sim, J. Koster, M. Bai, E. C. Aschenauer, Barbara Jacak, L. Ding, T. Kempel, Takahiro Nakamura, Alice Mignerey, L. D'Orazio, R. P. Pisani, R. Yang, Vladimir Samsonov, Norio Saito, Tsutomu Mibe, M. A. L. Leite, S. H. Lim, E. J. Desmond, D. Roach, K. M. Kijima, S. Bathe, Kensuke Homma, E. Richardson, Y. Tanaka, E. Mannel, Hiromi Iinuma, Senta Greene, A. Durum, S. Miyasaka, A. Ster, Christine Nattrass, J. S. Kapustinsky, V. Babintsev, M. Javani, L. Guo, Alexei Khanzadeev, Y. J. Kwon, C. P. Singh, Zhiying You, Agneta Oskarsson, B. Azmoun, Y. Berdnikov, S. H. Lee, Y. Akiba, M. Finger, K. Hashimoto, K. O. Eyser, Tomoya Tsuji, S. Dairaku, M. Tomášek, G. S. Kyle, B. Bassalleck, H. Qu, H. J. Moon, E. O'Brien, B. M. Johnson, Filip Krizek, Takao Sakaguchi, A. Sen, A. D. Frawley, S. V. Afanasiev, Yu. Efremenko, J. H. Kang, Y. Miyachi, J. S. Haggerty, S. R. Lee, Shinichi Masumoto, E. Stenlund, S. Huang, Aaron Angerami, J. S. Kang, R. A. Soltz, Tomofumi Nagae, R. Lacey, J. L. Nagle, P. Castera, M. Mendoza, S. N. White, Hideki Hamagaki, K. Aoki, M. Vargyas, G. David, T. Todoroki, K. I. Hahn, A. Isupov, M. Virius, S. Choi, C. L. Silva, Y. Nakamiya, Byung-Sik Hong, A. Bazilevsky, J. Sziklai, C. McKinney, S. Nagamiya, A. Taranenko, Atsushi Takahara, Y. Fukao, Vaclav Vrba, R. Granier de Cassagnac, W. A. Zajc, J. Sun, A. Adare, Charles Maguire, M. Gonin, M. Grosse Perdekamp, Brian Cole, E. Kistenev, D. E. Fields, D. M. Lee, R. S. Towell, T. Horaguchi, K. A. Drees, V. Baublis, O. Dietzsch, J. M. Durham, T. Hester, V. S. Pantuev, A. Denisov, Yuki Watanabe, M. Sano, V. Cianciolo, M. E. Connors, C. H. Chen, K. Watanabe, S. K. Park, K. Shoji, I. Garishvili, F. Wei, S. Baumgart, Y. S. Lai, M. McCumber, Maya Hachiya Shimomura, J. Rak, E. T. Atomssa, Rui Wei, A. Manion, Sergey Fokin, J. Klatsky, Yongsun Kim, T. V. Moukhanova, P. W. Stankus, S. Tarafdar, A. Sukhanov, D. Kawall, K. Kurita, Dmitry Blau, H. Pereira, K. Nakano, K. B. Kim, W. E. Sondheim, P. Kline, J. T. Mitchell, K. S. Lee, J. E. Frantz, D. Ivanischev, Minghui Liu, Ryugo S. Hayano, H. Asano, J. B. Choi, C. Gal, Julia Velkovska, K. Tanida, Jongmin Lee, M. Proissl, D. Winter, D. Yu Peressounko, Eva Haslum, K. Okada, Animesh Datta, J. Hanks, C. Y. Chi, A. Lebedev, A. Dion, J. Imrek, R. Seidl, Y. I. Makdisi, Vladislav Manko, M. Rosati, Tamás Csörgő, E. Vazquez-Zambrano, Kenneth Francis Read, J. Alexander, A. Nederlof, A. Enokizono, Beomkyu Kim, K. Boyle, P. A. Rukoyatkin, B. Sahlmueller, Zvi Hirsh Citron, T. Ichihara, H. A. Gustafsson, Gerd Joachim Kunde, M. Kurosawa, M. J. Leitch, C. O. Kim, A. Deshpande, A. Taketani, R. Belmont, S. Yokkaichi, Y. Riabov, C. A. Ogilvie, R. S. Hollis, M. Kasai, B. Meredith, R. Pak, Y. Tsuchimoto, T. K. Hemmick, Bhawani Singh, Kenta Shigaki, Yasuo Miake, I. Shein, B. Lewis, I. J. Choi, A. Kiss, H. Van Hecke, C. Vale, Jiangyong Jia, Henner Buesching, Y. Goto, Steve Edwards, Y. Ikeda, M. J. Tannenbaum, N. Grau, I. E. Yushmanov, M. Leitgab, K. Sedgwick, H. A. Torii, M. Slunečka, Mihael Makek, S. Kaneti, S. P. Sorensen, Toru Sugitate, Viktor Riabov, K. S. Joo, D. K. Mishra, D. Kleinjan, P. L. McGaughey, Motoi Inaba, J. C. Hill, X. Gong, R. Akimoto, K. V. Dharmawardane, A. S. Nyanin, François Fleuret, Jason Kamin, M. I. Nagy, A. V. Kazantsev, X. Bing, O. Chvala, E. Tennant, N. Apadula, Y. Watanabe, Takahiro Fusayasu, Rachid Nouicer, D. Watanabe, L. A. Linden Levy, A. N. Zelenski, C. Pinkenburg, L. Tomášek, Alexander Malakhov, M. Stepanov, G. Roche, A. Vossen, R. Petti, D. Silvermyr, E. Vznuzdaev, L. S. Zolin, M. Chiu, Ajit Kumar Mohanty, T. A. Shibata, L. Patel, A. Yanovich, S. Esumi, A. Iordanova, T. C. Awes, Kyoichiro Ozawa, D. Sharma, J. G. Lajoie, M. Soumya, T. Hachiya, J. Murata, Martin Purschke, C. A. Aidala, C. L. Woody, A. Berdnikov, D. Kotchetkov, R. K. Choudhury, A. Garishvili, I. V. Sourikova, D. Isenhower, M. Ouchida, Taku Gunji, S. Butsyk, S. D. Rolnick, Prashant Shukla, S. F. Pate, Ke. Nakamura, S. Motschwiller, V. Papavassiliou, A. Král, Alexander Milov, I. Nakagawa, Young-Ki Kim, T. Engelmore, N. Novitzky, O. Drapier, B. Love, A. G. Litvinenko, Bum-Hoon Lee, E. R. Kinney, D. P. Morrison, S. Campbell, B. H. Kang, R. Seto, M. Wysocki, B. Bannier, B. Fadem, H. Al-Ta'Ani, Tatsuya Chujo, T. Murakami, E. M. Takagui, M. Issah, I. Tserruya, K. N. Barish, Don McGlinchey, M. L. Brooks, V. Singh, D. Kotov, S. Sawada, J. Ying, A. Franz, M. Sarsour, R. Reynolds, S. P. Stoll, A. Glenn, Eunja Kim, Jen-Chieh Peng, D. Jouan, S. Wolin, Inkyu Park, Xiong Wang, Byoungchoo Park, Dong Jo Kim, A. Drees, and A. Veicht

Subjects
Nuclear physics, Physics, Published Erratum, General Physics and Astronomy
Published
2020

74. Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection

Author

J L, Faul, C P, Kerley, B, Love, E, O'Neill, C, Cody, W, Tormey, K, Hutchinson, L J, Cormican, and C M, Burke

Subjects
25-Hydroxyvitamin D 2, Male, Respiratory Distress Syndrome, SARS-CoV-2, Pneumonia, Viral, COVID-19, Vitamin D Deficiency, Severity of Illness Index, Betacoronavirus, Risk Factors, Disease Progression, Humans, Coronavirus Infections, Pandemics
Published
2020

75. Selective oxo ligand functionalisation and substitution reactivity in an oxo/catecholate-bridged U

Author

Bradley E, Cowie, Iskander, Douair, Laurent, Maron, Jason B, Love, and Polly L, Arnold

Subjects
Chemistry
Abstract

A UIV/UIV “Pacman” complex exhibits facile oxo-ligand functionalisation and substitution reactivity, owing to a bridging catecholate ligand that enhances the μ-oxo nucleophilicity and stabilises the resulting products., The oxo- and catecholate-bridged UIV/UIV Pacman complex [{(py)UIVOUIV(μ-O2C6H4)(py)}(LA)] A (LA = a macrocyclic “Pacman” ligand; anthracenylene hinge between N4-donor pockets, ethyl substituents on meso-carbon atom of each N4-donor pocket) featuring a bent UIV–O–UIV oxo bridge readily reacts with small molecule substrates to undergo either oxo-atom functionalisation or substitution. Complex A reacts with H2O or MeOH to afford [{(py)UIV(μ-OH)2UIV(μ-O2C6H4)(py)}(LA)] (1) and [{(py)UIV(μ-OH)(μ-OMe)UIV(μ-O2C6H4)(py)}(LA)] (2), respectively, in which the bridging oxo ligand in A is substituted for two bridging hydroxo ligands or one bridging hydroxo and one bridging methoxy ligand, respectively. Alternatively, A reacts with either 0.5 equiv. of S8 or 4 equiv. of Se to provide [{(py)UIV(μ-η2:η2-E2)UIV(μ-O2C6H4)(py)}(LA)] (E = S (3), Se (4)) respectively, in which the [E2]2– ion bridges the two UIV centres. To the best of our knowledge, complex A is the first example of either a d- or f-block bimetallic μ-oxo complex that activates elemental chalcogens. Complex A also reacts with XeF2 or 2 equiv. of Me3SiCl to provide [{(py)UIV(μ-X)2UIV(μ-O2C6H4)(py)}(LA)] (X = F (5), Cl (6)), in which the oxo ligand has been substituted for two bridging halido ligands. Reacting A with either XeF2 or Me3SiCl in the presence of O(Bcat)2 at room temperature forms [{(py)UIV(μ-X)(μ-OBcat)UIV(μ-O2C6H4)(py)}(LA)] (X = F (5A), Cl (6A)), which upon heating to 80 °C is converted to 5 and 6, respectively. In order to probe the importance of the bent UIV–O–UIV motif in A on the observed reactivity, the bis(boroxido)-UIV/UIV complex, [{(py)(pinBO)UIVOUIV(OBpin)(py)}(LA)] (B), featuring a linear UIV–O–UIV bond angle was treated with H2O and Me3SiCl. Complex B reacts with two equiv. of either H2O or Me3SiCl to provide [{(py)HOUIVOUIVOH(py)}(LA)] (7) and [{(py)ClUIVOUIVCl(py)}(LA)] (8), respectively, in which reactions occur preferentially at the boroxido ligands, with the μ-oxo ligand unchanged. The formal UIV oxidation state is retained in all of the products 1–8, and selective reactions at the bridging oxo ligand in A is facilitated by: (1) its highly nucleophilic character which is a result of a non-linear UIV–O–UIV bond angle causing an increase in U–O bond covalency and localisation of the lone pairs of electrons on the μ-oxo group, and (2) the presence of the bridging catecholate ligand, which destabilises a linear oxo-bridging geometry and stabilises the resulting products.

Published
2020

76. Co-extraction of Iron and Sulfate by Bis(2,4,4-trimethylpentyl)phosphinic Acid, CYANEX®272

Author

Jason B. Love, Peter A. Tasker, Innis Carson, Michael Moser, Boban Jakovljevic, Adam J. Fischmann, Soderstrom Matthew Dean, and Carole A. Morrison

Subjects
Solvent, chemistry.chemical_compound, Co extraction, Chemistry, General Chemical Engineering, General Chemistry, Sulfate, Solvent extraction, Nuclear chemistry
Abstract

The mode of action of iron(III) uptake from sulfate solutions by the commercial extractant CYANEX®272, bis(2,4,4-trimethylpentyl)phosphinic acid, has been studied using conventional solvent extraction methods, together with 31P{1 H} NMR spectroscopy, electrospray ionisation mass spectrometry, and DFT calculations that have not previously been used to analyse the content of the ISOPAR M water-immiscible phase. The maximum Fe-loading recorded was 177% of the theoretical maximum, based on the formation of an Fe(III) complex [Fe(L)3] with a 1:3 molar ratio of Fe to phosphinate (L). Inductively coupled plasma optical emission spectroscopy (ICP-OES) indicates that sulfate or hydrogen sulfate ions are co-extracted in a 1:2 molar ratio with iron across the whole of the Fe-loading range, which helps to account for the loadings being greater than 100% of the theoretical value. 31P{1 H} NMR spectroscopy indicates that the limiting factor in Fe-loading is the availability of uncomplexed CYANEX®272 (sulfate is present in large excess). In contrast to the behaviour of Co(II) and Zn(II) extraction by CYANEX®272, there is no evidence for the formation of polymeric Fe(III) complexes and highly viscous solutions at high metal loadings. The identity of the extracted species is likely to be a polynuclear Fe(III) sulfate complex.

Published
2020

77. Tantalum Recycling by Solvent Extraction: Chloride Is Better than Fluoride

Author

Carole A. Morrison, Jason B. Love, Luke M. M. Kinsman, Bryne T. Ngwenya, Rosa A. M. Crevecoeur, and Amrita Singh-Morgan

Subjects
lcsh:TN1-997, tantalum, Inorganic chemistry, Tantalum, chemical separation, chemistry.chemical_element, Halide, 02 engineering and technology, recycling, 010402 general chemistry, 01 natural sciences, Chloride, WEEE, Metal, chemistry.chemical_compound, medicine, General Materials Science, lcsh:Mining engineering. Metallurgy, Metals and Alloys, Aqueous two-phase system, 021001 nanoscience & nanotechnology, solvent extraction, 0104 chemical sciences, chemistry, visual_art, Reagent, visual_art.visual_art_medium, Leaching (metallurgy), 0210 nano-technology, Fluoride, medicine.drug
Abstract

The recycling of tantalum (Ta) is becoming increasingly important due to the criticality of its supply from a conflict mineral. It is used extensively in modern electronics, such as in capacitors, and so electronic waste is a potentially valuable secondary source of this metal. However, the recycling of Ta is difficult, not least because of the challenges of its leaching and subsequent separation from other metals. In this work, we show that Ta(V) halides, such as TaCl5 and TaF5, which can potentially be accessed from Ta metal upon acid halide leaching, can be recovered by solvent extraction using a simple primary amide reagent. The need for high halide concentrations in the aqueous phase implies the formation of the hexahalide salts [TaX6]&minus, (X = F, Cl) and that an anion-swing mechanism operates. While extraction of the fluorides is poor (up to 45%), excellent extraction under chloride conditions is found (&gt, 99%) and presents an alternative route to Ta recycling.

Published
2020
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78. 4CPS-184 Evaluation of a clinical pharmacy service on an inpatient ward in an acute hospital

Author

C Mc Gann, B Love, J Carr, E Dolan, and M O’Connor

Subjects
medicine.medical_specialty, business.industry, government.form_of_government, Pharmacist, Psychological intervention, Clinical pharmacy, Patient safety, Pharmaceutical care, Emergency medicine, government, Medicine, Activity-based costing, business, Grading (education), health care economics and organizations, Incident report
Abstract

Background and importance Intensive clinical pharmacy input from admission to discharge has been shown to improve patient outcomes. The clinical pharmacy service in our institution has historically been under-resourced. Aim and objectives The study aim was to develop a ward based clinical pharmacy service and to evaluate its impact using a number of clinical, safety and financial metrics. Material and methods A clinical pharmacist was assigned to provide pharmaceutical care to patients on a medicine for the older person ward. Over an 8 week period, the pharmacist prospectively recorded her interventions/activities. To assess impact on patient care, interventions were graded according to the Eadon criteria. The potential cost avoidance associated with interventions was estimated using two methods identified in the literature. Both define costs related to medication errors and calculate cost avoidance associated with clinical interventions based on prevention of harm. Medication incident reporting was analysed to assess the impact on patient safety. Results Eighty–four patients received a pharmacist review. Across a spectrum of activities, a total of 267 pharmacist interventions were recorded: 87% of patients had at least one pharmacist intervention. A total of 90% of interventions requiring follow–up with the medical team were accepted and resulted in a change to patient care. Eadon grading of interventions deemed that 81% of interventions improved the standard of patient care. Two different methods were used to estimate potential cost avoidance: one estimated annual savings of €154 103–€344 926; the other estimated these at €174 373. Given current pharmacist salary costs, this equates to a cost–benefit ratio of 2.8:1 to 6.3:1. (This does not include the 27% reduction in drug spend observed during the study period. However, more longitudinal data are required to confirm and characterise this phenomenon.) In the third quarter of 2018, 21 medication incidents were reported from the study ward compared with an average of 4 incident reports from the first and second quarters of 2018. This represents a fivefold increase in medication incident reporting, suggestive of an enhanced culture of patient safety. Conclusion and relevance This study assessed and quantified a wide spectrum of pharmacist contributions to medication management and safety. Costing of these contributions estimated the cost–benefit ratio of the clinical pharmacy service, providing compelling support for the extension of this service throughout the hospital. References and/or acknowledgements No conflict of interest.

Published
2020

79. 2SPD-011 Trans-interface gain share programme for biosimilar infliximab

Author

S Cullen, C Mc Gann, J Carr, and B Love

Subjects
Incentive, Procurement, business.industry, Conflict of interest, medicine, Operations management, Biosimilar, Pharmacy, Front loading, Business, Infliximab, Reimbursement, medicine.drug
Abstract

Background and importance Biosimilars offer substantial savings to healthcare systems. In Ireland, however, prescriber hesitance remains an obstacle to their introduction. In June 2013, biosimilar infliximab was licensed by the EMA. Despite being one of the first European countries with commercial availability, penetration of the Irish market was only 25% in April 2018. In a Dublin acute hospital, a novel system for infliximab reimbursement exists across the primary and secondary care interface. This presented further challenges to implementing a biosimilar switch programme due to the lack of perceivable incentives for key stakeholders. Aim and objectives This descriptive review outlines the development of a trans-interface gain sharing (TIGS) programme catalysing the introduction of biosimilar infliximab in an Irish acute hospital. Material and methods Trans-interface engagement with key stakeholders began in 2017. Within the acute hospital, multiple impediments to biosimilar adoption were identified. In September 2018, the parameters of the TIGS programme were finalised, projecting cost saving for primary care and creating an income stream for secondary care, to be used for service development and enhancement. Achievement of procurement savings was the primary outcome of this study, with the impact of income generation within the acute hospital as secondary outcomes. Results Within 12 months of commencing the TIGS programme, the percentage of patients on biosimilar infliximab increased from 25% to 95%. Despite a 3.5% increase in infliximab usage, the procurement cost decreased by 45.4% (projected full year saving for 2019 of €859 372). To stimulate rapid uptake, the TIGS programme apportioned 80% of the savings to the acute hospital for at least the first 2 years. These savings were invested in pharmacy and rheumatology frontline services and provided the budgetary headroom to support increased access to alternative biologic therapies in gastroenterology (51.6% growth in access to vedolizumab). Conclusion and relevance In its first year, the TIGS programme stimulated successful introduction of biosimilar infliximab with projected procurement savings of almost €1m. The front loading of savings to frontline services will continue for a further 12–18 months, with recalibration of the gain share arrangement in 2021. References and/or acknowledgements No conflict of interest.

Published
2020

80. Pressure-induced inclusion of neon in the crystal structure of a molecular Cu2(pacman) complex at 4.67 GPa

Author

Simon Parsons, Christine M. Beavers, Konstantin V. Kamenev, Nico Giordano, Jason B. Love, James R. Pankhurst, and Simon J. Teat

Subjects
Materials science, Ligand, Organic Chemistry, Metals and Alloys, chemistry.chemical_element, General Chemistry, Crystal structure, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Neon, Crystallography, Adsorption, chemistry, Void space, Chemical Sciences, Materials Chemistry, Ceramics and Composites, Inclusion (mineral), Ambient pressure
Abstract

Crystals of a Cu complex of the macrocyclic Schiff-base calixpyrrole or 'Pacman' ligand, Cu2(L), do not contain any solvent-accessible void space at ambient pressure, but adsorb neon at 4.67 GPa, forming Cu2(L)·3.5Ne.

Published
2020

82. Cellular basis of tissue regeneration by omentum.

Author

Shivanee Shah, Erin Lowery, Rudolf K Braun, Alicia Martin, Nick Huang, Melissa Medina, Periannan Sethupathi, Yoichi Seki, Mariko Takami, Kathryn Byrne, Christopher Wigfield, Robert B Love, and Makio Iwashima

Subjects
Medicine, Science
Abstract

The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells.Omentum consists of a variety of phenotypically and functionally distinctive cells. To understand the mechanism of tissue repair support by the omentum in more detail, we analyzed the cell subsets derived from the omentum on immune and inflammatory responses. Our data demonstrate that the omentum contains at least two groups of cells that support tissue repair, immunomodulatory myeloid derived suppressor cells and omnipotent stem cells that are indistinguishable from mesenchymal stem cells. Based on these data, we propose that the omentum is a designated organ for tissue repair and healing in response to foreign invasion and tissue damage.

Published
2012
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83. The Supramolecular and Coordination Chemistry of Cobalt(II) Extraction by Phosphinic Acids

Author

Carole A. Morrison, Peter A. Tasker, Boban Jakovljevic, Adam J. Fischmann, Jason B. Love, Innis Carson, Michael Moser, and Soderstrom Matthew Dean

Subjects
chemistry.chemical_classification, Extraction (chemistry), Supramolecular chemistry, chemistry.chemical_element, Industrial chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Coordination complex, Inorganic Chemistry, 020401 chemical engineering, chemistry, Phosphinic Acids, Organic chemistry, Self-assembly, 0204 chemical engineering, Cobalt
Abstract

A combination of mass spectrometry, DFT calculations and 31P{1H} NMR spectroscopy has been used to define the mode of action of the commercial cobalt extractant, bis(2,4,4-trimethylpentyl)phosphinic acid (CYANEX®272, L1H) in Co recovery. The nature of the Co(II)-complexes formed in the water-immiscible phase is determined largely by the propensity of phosphinates to form strong interligand H-bonds in the outer coordination sphere and also to form stable µ2-Co-O-P-O-Co bridges. At low Co loading levels, the predominant species is the 4:1 complex, [Co(L1.L1H)2], in which coordinated neutral phosphinic acid ligands form strong H-bonds to adjacent anionic phosphinates. At higher Co loading, oligomers such as [(L1.L1H)Co(L12Co)n(L1.L1H)] are formed with µ2-phosphinate bridging, resulting in a substantial increase in the viscosity of the water-immiscible phase. The presence of tris(2,4,4-trimethylpentyl)phosphine oxide (L2) in the commercial formulation reduces the viscosity because its incorporation into oligomeric complexes such as [(L2)Co{L13CoL1CoL13Co}mL1] can terminate chains, resulting in a lower average molecular weight. The uptake of Zn by L1H shows a very similar dependence of viscosity on loading, and DOSY spectra and mass spectrometry demonstrate that higher molecular weight species are present at high Zn loading.

Published
2018

84. Interactions of vanadium(<scp>iv</scp>) with amidoxime ligands: redox reactivity

Author

Zhiyong Zhang, John Arnold, Bernard F. Parker, James R. Pankhurst, Stephan Hohloch, Jason B. Love, and Linfeng Rao

Subjects
Chemistry, chemistry.chemical_element, Vanadium, Sorption, 02 engineering and technology, Uranium, 010402 general chemistry, 021001 nanoscience & nanotechnology, Oxime, 01 natural sciences, Redox, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, Oxidation state, Oxidizing agent, Polymer chemistry, Reactivity (chemistry), 0210 nano-technology
Abstract

The use of amidoxime-functionalized polymer fibers as a sorbent for uranium has attracted recent interest for the extraction of uranium from seawater. Vanadium is one of the main competing ions for uranium sorption as V(v) species, however, vanadium is also present as V(iv) in seawater. In the present study, the interactions of V(iv) with amidoxime and similar ligands were explored. Attempts were made to synthesize V(iv) complexes of glutaroimide-dioxime, a molecular analogue of polymer sorbents. However, V(iv) was found to react irreversibly with glutaroimide-dioxime and other oxime groups, oxidizing to the V(v) oxidation state. We have explored the reactions and propose mechanisms, as well as characterized the redox behavior of the vanadium-glutaroimide-dioxime complex.

Published
2018

85. Optimization of process parameters for the selective leaching of copper, nickel and isolation of gold from obsolete mobile phone PCBs

Author

Carole A. Morrison, Kamalesh K. Singh, Mudila Dhanunjaya Rao, and Jason B. Love

Subjects
Materials science, TJ807-830, Environmental engineering, chemistry.chemical_element, Renewable energy sources, chemistry.chemical_compound, Response surface methodology, Nickel, Nitric acid, Selective leaching, Electrical and Electronic Engineering, Base metal, Dissolution, Waste printed circuit boards, Metallurgy, Building and Construction, TA170-171, Copper, Kinetics, chemistry, Reagent, Leaching, Leaching (metallurgy)
Abstract

The sequential separation of base and precious metals from the end-of-life mobile phone printed circuit boards (PCBs) is a significant challenge for the development of recycling process that exhibit material circularity. In this contribution, a simple, eco-friendly, and efficient leaching process is developed for the dissolution of copper and nickel from obsolete mobile phone PCBs to facilitate the isolation of a gold-rich residue. Chemical pre-treatment of downsized PCBs produced a metallic portion for which the leaching parameters for copper and nickel were optimised, including the type of leaching reagent, temperature, time, pulp density and agitation speed. It was found that quantitative dissolution of base metals occurred using 3.0 M nitric acid at 30 °C with a 50 g/L pulp density, 2 h residence time, and 500 rpm stirring speed; under these conditions, no gold was dissolved. Design of Experiment analysis using Response Surface Methodology was also undertaken to validate the process. Finally, the kinetics of the leaching process were studied and shown to conform to the chemically controlled surface reaction model, with activation energies of 39.7 and 18.4 kJ/mol for copper and nickel. Importantly, the leaching process optimised in this work avoids the need for high temperatures and reduces energy consumption and effluent generation, leading to the cleaner processing of obsolete mobile phone PCBs for the separation of gold from the dominant base metals.

Published
2021

86. Pin1 modulates the type 1 immune response.

Author

Stephane Esnault, Ruedi K Braun, Zhong-Jian Shen, Zhuzai Xiang, Erika Heninger, Robert B Love, Matyas Sandor, and James S Malter

Subjects
Medicine, Science
Abstract

BACKGROUND/ABSTRACT: Immune responses initiated by T cell receptor (TCR) and costimulatory molecule mediated signaling culminate in maximal cytokine mRNA production and stability. The transcriptional responses to co-stimulatory T cell signalling involve calcineurin and NF-AT, which can be antagonized by interference with the cis-trans peptidyl-prolyl isomerases (PPIase), cyclophilin A and FKBP. Signalling molecules downstream of CD28 which are essential for the stabilization of cytokine mRNAs are largely unknown.We now show that Pin1, a third member of the PPIase family mediates the post-transcriptional regulation of Th1 cytokines by activated T cells. Blockade of Pin1 by pharmacologic or genetic means greatly attenuated IFN-gamma, IL-2 and CXCL-10 mRNA stability, accumulation and protein expression after cell activation. In vivo, Pin1 blockade prevented both the acute and chronic rejection of MHC mismatched, orthotopic rat lung transplants by reducing the expression of IFN-gamma and CXCL-10. Combined transcriptional and post-transcriptional blockade with cyclosporine A and the Pin1 inhibitor, juglone, was synergistic.These data suggest Pin1 inhibitors should be explored for use as immunosuppressants and employed with available calcineurin inhibitors to reduce toxicity and enhance effectiveness.

Published
2007
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88. Cover Feature: Simple Amides and Amines for the Synergistic Recovery of Rhodium from Hydrochloric Acid by Solvent Extraction (Chem. Eur. J. 34/2021)

Author

Alexander Bouch, Jason B. Love, Emma R. Schofield, Gary S. Nichol, Andrew I. Carrick, Jane Patrick, Carole A. Morrison, and Euan D. Doidge

Subjects
chemistry.chemical_compound, chemistry, Hydrometallurgy, Organic Chemistry, chemistry.chemical_element, Organic chemistry, Hydrochloric acid, General Chemistry, Solvent extraction, Catalysis, Rhodium
Published
2021

89. On the Extraction of HCl and H2PtCl6 by Tributyl Phosphate: A Mode of Action Study

Author

Ross J. Ellis, Peter A. Tasker, Carole A. Morrison, Stephen Woollam, Kirstian J. MacRuary, Ross J. Gordon, Richard A. Grant, and Jason B. Love

Subjects
010405 organic chemistry, Chemistry, General Chemical Engineering, Inorganic chemistry, Extraction (chemistry), Aqueous two-phase system, Hydrochloric acid, General Chemistry, 010402 general chemistry, 01 natural sciences, Chloride, Toluene, 0104 chemical sciences, chemistry.chemical_compound, Action study, Solvation shell, medicine, Tributyl phosphate, medicine.drug
Abstract

Combining computational modeling with experimental measurements has revealed the self-assembly of nano-aggregate structures in the transfer of HCl and PtCl62– from an aqueous phase into toluene by the common industrial extractant tributyl phosphate (TBP). Molecular dynamics simulations have been coupled to analytical measurements to provide an atomistic interpretation of the mode of action of TBP under 6 M and 10 M HCl conditions. The structures conform to reverse micelles, where the Cl– or PtCl62– core is encapsulated by a hydration shell that acts as a mediating bridge to the electronegative oxygen atom in the TBP phosphate groups. For the 6 M HCl extraction model, the data support stable aggregates forming from 2–3 TBP molecules around one chloride anion if the number of water molecules encapsulating the chloride anion is no more than five; increasing the water content to 10 molecules allows a fourth TBP molecule to coordinate. For the 10 M HCl extraction model, stable structures are obtained that conform to the empirical formula (TBP.HCl.H2O)3–5. At 6 M HCl, extraction of PtCl62– is achieved by encapsulation by four TBP molecules; the data for extraction at 10 M HCl indicate larger aggregates containing multiple PtCl62– anions are likely to be forming. In all cases, the hydrated core regions of the reverse micelles are considerably exposed. The diameters of the self-assembled structures around chloride ions agree well with available literature data from small-angle neutron-scattering experiments.

Published
2017

90. Rational Synthesis and Electronic Structure of Functionalized Trinuclear Pd Metal Sheet Sandwich Complexes

Author

Alexander Pöthig, Christian Jandl, James R. Pankhurst, and Jason B. Love

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, Binding properties, Charge density, Electronic structure, Metal sheet, 010402 general chemistry, Electrochemistry, 01 natural sciences, 0104 chemical sciences, Characterization (materials science), Inorganic Chemistry, Crystallography, Computational chemistry, Oxidation state, Computational analysis, Physical and Theoretical Chemistry
Abstract

In this article we present the rational synthesis and full characterization of molecular Pd3 clusters sandwiched by imidazolium- and pyridinium-functionalized cycloheptatrienide ligands, of general formula [Pd3Br3(C7H6R)2]+. From functionalized η3-cycloheptatrienide Pd complexes as starting materials, PdBr2(η3-C7H6R), a number of synthetic routes were tested and a generally applicable strategy was developed on the basis of the formation of dimeric “preclusters”, [{PdBr(η3-C7H6R)}2(μ-Br)]+, which exhibit a Pd–Pd interaction. Spectroscopic and electrochemical results indicate a noninteger, common oxidation state of Pd in the trinuclear clusters, and crystallographic analysis reveals distinct differences in the binding properties of the Pd atoms in the solid state, suggesting that in certain environments there are even two discernible oxidation states, which is supported by computational analysis of the charge distribution.

Published
2017

91. Triggering Redox Activity in a Thiophene Compound: Radical Stabilization and Coordination Chemistry

Author

Massimiliano Curcio, Stephen Sproules, Dimitri Mignard, Jason B. Love, and James R. Pankhurst

Subjects
chemistry.chemical_classification, Half-reaction, 010405 organic chemistry, Stereochemistry, Metalation, General Medicine, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Redox, Catalysis, 0104 chemical sciences, Coordination complex, Ion, Redox Activity, Dication, chemistry.chemical_compound, chemistry, Thiophene
Abstract

The synthesis, metalation, and redox properties of an acyclic bis(iminothienyl)methene L− are presented. This π-conjugated anion displays pronounced redox activity, undergoing facile one-electron oxidation to the acyclic, metal-free, neutral radical L* on reaction with FeBr2. In contrast, reaction of L− with CuI forms the unique, neutral Cu2I2(L*) complex of a ligand-centered radical, whereas reaction with the stronger oxidant AgBF4 forms the metal-free radical dication L*2+.

Published
2017

92. Metal-binding motifs of alkyl and aryl phosphinates; versatile mono and polynucleating ligands

Author

Euan D. Doidge, Jason B. Love, Peter A. Tasker, Carole A. Morrison, Mary R. Healy, and Innis Carson

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, Chemistry, Hydrogen bond, Aryl, Phosphinate, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, Metal, chemistry.chemical_compound, visual_art, Polymer chemistry, Materials Chemistry, visual_art.visual_art_medium, Crystallographic database, Metal-organic framework, Carboxylate, Physical and Theoretical Chemistry, Alkyl
Abstract

An analysis of 552 structures of metal complexes of alkyl and arylphosphinates in the Cambridge Crystallographic Database shows that the phosphinate ligating group is remarkably versatile and is able to adopt ten different binding motifs in both mono- and polynuclear complexes in which an individual phosphinate group can bind to up to five metal atoms. The majority of both homo- and heteroleptic complexes contain Msingle bondOsingle bondPR2double bond; length as m-dashOsingle bondM units in oligomeric and polymeric structures. In many heteroleptic complexes ligands containing hydrogen bond donors form strong bonding interactions with the phosphinate, generating pseudochelated structures. Similar pseudochelates, −Osingle bondPR2double bond; length as m-dashO⋯Hsingle bondOsingle bondPR2double bond; length as m-dashO, are formed when both a phosphinate and its parent phosphinic acid are coordinated to a single metal atom. Such structures feature also in the solution chemistry involved in metal extraction processes using phosphinate ligands. As might be expected, many of the binding motifs found in phosphinate complexes are similar to those in carboxylate complexes but there are fewer examples of phosphinates being used to form metal organic frameworks.

Published
2017

93. Assigning Peptide Disulfide Linkage Pattern Among Regio-Isomers via Methoxy Addition to Disulfide and Tandem Mass Spectrometry

Author

Xiaoxiao Ma, Chasity B. Love-Nkansah, Kirt L. Durand, Craig A. Stinson, Yu Xia, and Lei Tan

Subjects
Collision-induced dissociation, Ultraviolet Rays, Stereochemistry, Disulfide Linkage, Peptide, 010402 general chemistry, Tandem mass spectrometry, 01 natural sciences, chemistry.chemical_compound, Isomerism, Tandem Mass Spectrometry, Structural Biology, Insulin, Organic chemistry, Cysteine, Disulfides, Protein disulfide-isomerase, Spectroscopy, chemistry.chemical_classification, 010401 analytical chemistry, Sulfoxide, 0104 chemical sciences, chemistry, Thiol, Peptides
Abstract

Pinpointing disulfide linkage pattern is critical in the characterization of proteins and peptides consisting of multiple disulfide bonds. Herein, we report a method based on coupling online disulfide modification and tandem mass spectrometry (MS/MS) to distinguish peptide disulfide regio-isomers. Such a method relies on a new disulfide bond cleavage reaction in solution, involving methanol as a reactant and 254 nm ultraviolet (UV) irradiation. This reaction leads to selective cleavage of a disulfide bond and formation of sulfenic methyl ester (–SOCH3) at one cysteine residue and a thiol (–SH) at the other. Under low energy collision-induced dissociation (CID), cysteine sulfenic methyl ester motif produces a signature methanol loss (–32 Da), allowing its identification from other possible isomeric structures such as S-hydroxylmethyl (–SCH2OH) and methyl sulfoxide (–S(O)-CH3). Since disulfide bond can be selectively cleaved and modified upon methoxy addition, subsequent MS2 CID of the methoxy addition product provides enhanced sequence coverage as demonstrated by the analysis of bovine insulin. More importantly, this reaction does not induce disulfide scrambling, likely due to the fact that radical intermediates are not involved in the process. An approach based on methoxy addition followed by MS3 CID has been developed for assigning disulfide linkage patterns in peptide disulfide regio-isomers. This methodology was successfully applied to characterizing peptide systems having two disulfide bonds and three disulfide linkage isomers: side-by-side, overlapped, and looped-within-a-loop configurations.

Published
2017

95. Recent Advances in the Deoxydehydration of Vicinal Diols and Polyols

Author

Liam J. Donnelly, Stephen P. Thomas, and Jason B. Love

Subjects
Green chemistry, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Alkene, Organic Chemistry, Diol, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Homogeneous, Selectivity, Deoxygenation, Vicinal
Abstract

Deoxydehydration (DODH) is one of the most promising tools to reduce the oxygen content of biomass (sugars and polyols) and provide analogues of platform chemicals that are derived from fossil resources. This reaction converts a vicinal diol into an alkene and is typically catalyzed by high-oxidation-state metal-oxo compounds in the presence of a stoichiometric reductant, with examples of both homogeneous and heterogeneous systems. This mini-review will highlight the developments in this field over the past 5 years and focus on efforts to solve the problems that currently prevent DODH being performed on a commercial scale, including the nature of the reductant, substrate scope and selectivity, and catalyst recovery and expense.

Published
2019

97. Thermal and Photochemical Reduction and Functionalization Chemistry of the Uranyl Dication, [U VI O2] 2+

Author

Bradley E. Cowie, Jamie M. Purkis, Jason B. Love, Jonathan Austin, and Polly L. Arnold

Subjects
010405 organic chemistry, General Chemistry, 010402 general chemistry, Photochemistry, Uranyl, 01 natural sciences, 0104 chemical sciences, Ion, Dication, Reduction (complexity), chemistry.chemical_compound, chemistry, Covalent bond, Thermal, Anaerobic reaction, Surface modification
Abstract

The uranyl ion, [UVIO2]2+, possesses rigorously trans, strongly covalent, and chemically robust Uoxo groups. However, through the use of anaerobic reaction techniques, both one and two-electron reductive functionalization of the uranyl oxo groups have been discovered and developed. Prior to 2010, this unusual reactivity centered around the reductive silylation of the uranyl ion which entailed conversion of the oxo ligands into siloxy ligands, and reductive metalation of the uranyl oxo with Group 1 and f-block metals. This review surveys the large number of new examples of reductive functionalization of the uranyl ion that have been reported since 2010, including reductive borylation and alumination, metalation with d- or f-block metals, and new examples of reductive silylation. Other examples of oxo-group functionalization of [UVIO2]2+ that do not involve reduction, mainly with Group 1 cations, are also covered, along with new advances in the photochemistry of the uranyl(VI) ion that involve the transient formation of formally uranyl(V) [UVO2]+ ion.

Published
2019

98. Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions

Author

A. Sen, V. S. Pantuev, M. Sano, M. Stepanov, Emily D. Richardson, X. He, J. Zimamyi, O. O. Omiwade, M. Harvey, S. Belikov, K. S. Joo, A. Rakotozafindrabe, J. Hamblen, K. Hasuko, Y. Aramaki, V. Peresedov, Y. Watanabe, Ajit Kumar Mohanty, T. A. Shibata, C. L. Silva, R. A. Soltz, T. Sato, C. M. Camacho, R. S. Towell, Prashant Shukla, S. F. Pate, Dmitry Blau, Y. Fukao, A. Shevel, O. Jinnouchi, H. En'yo, J. Koster, M. Grosse Perdekamp, A. Hadj Henni, T. Hester, I. Younus, Ke. Nakamura, O. Drapier, H. Al-Bataineh, E. Vazquez-Zambrano, A. Nederlof, J. Park, H. Masui, A. K. Dubey, F. Matathias, H. Asano, Florian Bauer, M. Kasai, Y. Iwanaga, Joakim Nystrand, A. Vossen, T. L. Thomas, I. E. Yushmanov, Eun-Hee Kim, P. Constantin, Beomkyu Kim, Wei Xie, M. J. Leitch, A. A. Bickley, C. L. Woody, A. Veicht, A. Mwai, Eva Haslum, B. Lenzi, A. Soldatov, D. Isenhower, A. Toia, Tamas Novak, T. Moon, Kensuke Homma, H. Pei, L. Guo, Alexei Khanzadeev, Shinichi Masumoto, E. Stenlund, J. B. Choi, H. Sakata, Min-Hye Kim, R. Vértesi, S. H. Lee, Dipak Kumar Mishra, C. Baumann, M. S. Daugherity, C. P. Singh, T. Jones, Z. Rowan, Tomoya Tsuji, J. H. Bhom, T. V. Moukhanova, M. Mendoza, Peter Christiansen, R. Ichimiya, Atsushi Takahara, L. Mašek, D. Kawall, K. Tanida, Ryugo S. Hayano, I. J. Choi, B. Xia, S. Motschwiller, D. Ivanishchev, Dennis Perepelitsa, H. Themann, S. Chernichenko, V. Papavassiliou, Z. Ji, D. Winter, D. Yu Peressounko, Y. Riabov, Y. Onuki, C. E. Perezlara, Filip Krizek, N. A. Lewis, K. A. Drees, H. Lim, B. Bassalleck, S. Takagi, J. Bryslawskyj, Kenta Shigaki, M. Boer, M. Nguyen, V. I. Kochetkov, L. Aphecetche, S. Park, J. Murata, I. Nakagawa, Aaron Angerami, V-N. Tram, N. Grau, R. J. Petti, Sándor Lökös, K. N. Barish, J. M. Burward-Hoy, P. Tarján, S. N. White, J. G. Lajoie, Deepa Thomas, Jan Rak, R. Lacey, A. V. Kazantsev, Alexander Milov, Tae-Yeon Lee, Martin Purschke, C. A. Aidala, H. J. Kim, R. Granier de Cassagnac, A. Isupov, C. Suire, A. S. Nyanin, S. Zharko, S. Sano, S. Butsyk, Vladimir Samsonov, M. Konno, Gerd Joachim Kunde, A. Dion, Johannes Peter Wessels, I. Ravinovich, J. L. Charvet, S. Afanasiev, A. Ster, N. Feege, I. Otterlund, Christine Nattrass, A. Adare, J. Klatsky, C. P. Wong, M. Connors, W. A. Zajc, V. Baublis, A. Denisov, M. Leitgab, J. Sziklai, I. Shein, V. Cianciolo, Zvi Hirsh Citron, H. Ge, Rachid Nouicer, A. N. Zelenski, M. Proissl, Young-Ki Kim, T. Engelmore, Y. Tomita, Motoi Inaba, K. Nakano, M. J. Skoby, J. Newby, G. Roche, M. Mitrovski, Takafumi Niida, J. Huang, Hiroaki Ohnishi, K. B. Lee, Brian Cole, L. Tomášek, R. M. Wright, T. E. Miller, M. Kurosawa, Sergey Fokin, Z. Sun, A. Yu. Semenov, Bum-Hoon Lee, D. E. Mihalik, Senta Greene, K. Sedgwick, M. L. Brooks, S. Yokkaichi, W. C. Smith, B. M. Johnson, Alberto Baldisseri, Mihael Makek, K. Das, J. T. Mitchell, P. Mikeš, N. Hotvedt, R. Seidl, M. K. Dayananda, Prakhar Garg, B. Bannier, R. Belmont, M. Sarsour, A. T. Basye, M. K. Lee, B. Love, Marie Germain, C. Xu, E. P. Hartouni, Y. Miyachi, K. B. Kim, W. E. Sondheim, K. Boyle, P. A. Rukoyatkin, K. S. Sim, Kei Nagashima, V. Canoa Roman, P. Chung, M. I. Nagy, A. Morreale, Z. Fraenkel, Y. Nagata, M. Bai, D. Watanabe, M. D. Malik, Vladislav Manko, Saskia Mioduszewski, H. A. Gustafsson, M. Slunečka, E. Vznuzdaev, E. C. Aschenauer, S. S. Ryu, J. S. Kang, Junji Tojo, J. Gosset, Mate Csanad, A. Berdnikov, C. Zhang, J. P. Sullivan, A. Iordanova, A. Caringi, Frank Ellinghaus, E. R. Kinney, D. P. Morrison, B. H. Kang, M. Naglis, Tomofumi Nagae, J. L. Nagle, S. Y. Fung, M. B. Deaton, Y. Tanaka, T. K. Shea, P. Rosnet, B. Meredith, V. Khachatryan, D. Hornback, B. Komkov, P. Castera, J. Imrek, V. E. Semenov, B. E. Norman, M. Holmes, P. Ružička, Raphael Noel Tieulent, W. S. Emam, A. Datta, M. Javani, B. Fadem, E. O'Brien, Y. Kwon, A. G. Litvinenko, A. Kozlov, R. Seto, A. Bagoly, Maya Hachiya Shimomura, R. S. Hollis, G. David, L. Patel, T. C. Awes, Kyoichiro Ozawa, T. Liška, K. O. Eyser, K. Fujiwara, Y. L. Yamaguchi, N. Kamihara, R. K. Choudhury, T. Murakami, Robert F. Hobbs, B. Lewis, Viktor Riabov, Jun Kikuchi, Tadaaki Isobe, B. Azmoun, Y. J. Mao, K. Haruna, T. W. Danley, J. D. Osborn, A. Taranenko, R. Yang, H. Hiejima, S. Taneja, Kazushi Miki, H. Al-Ta'Ani, A. Král, M. J. Kweon, H. Kanou, J. S. Chai, Petr Gallus, T. Majoros, L. Ding, D. Roach, K. M. Kijima, Taku Gunji, H. Gong, M. Nihashi, Tatsuya Chujo, D. Richford, Zhiying You, K. Imai, Shoji Nagamiya, John Hill, K. Hashimoto, T. Horaguchi, Brajesh K. Singh, C. Silvestre, R. Bennett, M. Kawashima, J. Seele, Yoshifumi Ueda, H. J. Moon, Norio Saito, Tsutomu Mibe, P. Liebing, M. A. L. Leite, D. Sharma, C. Vale, P. L. McGaughey, K. Karatsu, M. Patel, F. Kajihara, F. Staley, L. Baksay, V. Dzhordzhadze, I. Danchev, A. Garishvili, David D'Enterria, Gary Grim, J. H. Do, T. Tabaru, S. Batsouli, B. Kurgyis, Toru Sugitate, L. D. Isenhower, K. V. Dharmawardane, Susumu Sato, Y. I. Makdisi, M. Kaneta, Xingguo Li, B. S. Chang, Y. Le Bornec, Ahmed Al-Jamel, Marisilvia Donadelli, V. Bumazhnov, M. P. Comets, Charles Maguire, J. L. Drachenberg, S. Leckey, M. Finger, S. Tarafdar, G. Mitsuka, Y. Hori, Anne Marie Sickles, J. Jin, J. E. Frantz, Jen-Chieh Peng, K. Gainey, I. V. Sourikova, N. Novitzky, Jongmin Lee, S. Choi, J. Klay, S. I. Morrow, H. Delagrange, Y. S. Kim, Y. H. Leung, Josh Moss, E. M. Takagui, S. P. Sorensen, Dylan Walker, R. P. Pisani, Debashish Pal, Y. Nakamiya, D. Lynch, S. Sawada, J. S. Bok, D. Kotchetkov, D. Reynolds, François Fleuret, H. W. Van Hecke, Y. Tsuchimoto, T. Ichihara, M. Oka, O. Chvala, H. Iinuma, M. C. McCain, S. Hasegawa, R. Tanabe, D. Layton, I. Garishvili, Akio Kiyomichi, J. Ying, Seong H. Kim, F. Wei, Inkyu Park, M. McCumber, J. Runchey, E. Kistenev, Xiong Wang, Z. Conesa del Valle, S. Zhou, Matthew G. Reuter, Herve Borel, B. Ujvari, Nikolay Tyurin, M. N. Wagner, Susanta K. Mohapatra, J. S. Kapustinsky, Takahiro Fusayasu, G. R. Young, M. Alfred, T. Hachiya, G. Baksay, Dong Jo Kim, A. P.T. Palounek, K. Okada, P. Lichtenwalner, A. Kiss, P. Kline, K. S. Lee, S. D. Rolnick, A. Enokizono, B. Espagnon, L. Zou, H. Harada, I. D. Ojha, Alexander Malakhov, Qiao Xu, N. Kurihara, ShinIchi Esumi, A. Glenn, A. Kravitz, J. M. Heuser, W. C. Chang, Z. Yasin, Henner Buesching, J. Sun, B. Forestier, M. T. Bjorndal, D. Silvermyr, S. Baumgart, L. S. Zolin, M. Ouchida, V. Babintsev, W. J. Park, Steve Edwards, M. Tomášek, N. Means, J. Asai, Atsushi Taketani, M. Wysocki, I. Tserruya, Masamichi Ishihara, A. Sukhanov, K. Kurita, Rushan Han, M. N. Hagiwara, Christopher Rosen, S. H. Lim, H. Pereira, P. D. Barnes, H. Yu, X. Gong, Y. Morino, Yu. Efremenko, A. Yanovich, V. Singh, V. L. Rykov, T. Dahms, A. Hodges, Marcus Hohlmann, G. S. Kyle, C. O. Kim, R. Pak, N. Willis, C. Y. Chi, M. J. Tannenbaum, James Alexander, Y. Ikeda, Shingo Sakai, S. P. Stoll, L. A. Linden Levy, J. G. Boissevain, Yasutada Akiba, H. Torii, P. V. Radzevich, Hirohiko Sato, S. K. Tuli, Minghui Liu, S. Bathe, Eunja Kim, E. J. Mannel, Agneta Oskarsson, S. Dairaku, D. Kincses, T. Rinn, Y. Berdnikov, R. Averbeck, Byung-Sik Hong, C. McKinney, M. Mishra, Kazuhiro Tanaka, Vaclav Vrba, Klaus Johannes Reygers, K. Hill, O. Zaudtke, Rui Wei, R. Akimoto, B. Sahlmueller, E. J. Desmond, A. Bazilevsky, Y. J. Kim, B. K. Schmoll, M. Virius, E. T. Atomssa, M. Heffner, A. Kim, Jaehyeok Yoo, D. Mukhopadhyay, E. Tennant, S. Rembeczki, M. Gonin, C. Pinkenburg, K. Dehmelt, J. D. Orjuela Koop, S. Kametani, C. H. Chen, Kenneth Francis Read, A. Manion, Y. Cobigo, Alexandre Lebedev, J. H. Kang, D. M. Lee, D. Bucher, J. S. Haggerty, S. R. Lee, A. Romana, S. Gadrat, Y. S. Lai, K. Kiriluk, J. Chiba, Alice Mignerey, X. Jiang, L. D'Orazio, S. Miyasaka, A. Franz, G. C. Mishra, Xiao-yan Li, Hiroyuki Sako, Y. Komatsu, Takao Sakaguchi, S. W. Nam, C. Klein-Boesing, A. D. Frawley, S. Huang, S. H. Aronson, W. Holzmann, O. Dietzsch, H. Valle, M. Chiu, Dipanwita Dutta, C. A. Ogilvie, Sung Keun Park, C. Gal, Julia Velkovska, S. Kelly, M. Rosati, N. N. Ajitanand, T. K. Hemmick, J. M. Durham, Yasuo Miake, Tamás Csörgő, Takahiro Nakamura, D. McGlinchey, Susumu Oda, A. A. Vinogradov, Henrik Tydesjö, L. Kochenda, M. Issah, T. Shohjoh, A. Durum, T. Kawagishi, Jiangyong Jia, D. S. Brown, K. Yamaura, S. Wolin, D. Kleinjan, S. Campbell, Hongfang Liu, D. E. Fields, B. V. Jacak, A. K. Purwar, R. Armendariz, J. Hanks, Byoungchoo Park, N. Apadula, C. Oakley, A. Drees, J. Kubart, K. Sakashita, D. Kotov, J. Egdemir, D. S. Jumper, F. Gastineau, Jason Kamin, Y. Goto, S. S.E. Rosendahl, K. Watanabe, G. Bunce, K. Shoji, A. Churyn, D. Jouan, W. Peng, P. W. Stankus, C. R. Cleven, C. Haegemann, Y. Inoue, P. J. Kroon, T. Kempel, Dong-Hun Kim, S. Kaneti, M. G. Hur, Steven E. Skutnik, M. Togawa, T. O. S. Haseler, H. Qu, Hideki Hamagaki, W. Fan, K. Aoki, M. Vargyas, T. Todoroki, K. I. Hahn, A. Deshpande, Helsinki Institute of Physics, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), PHENIX, Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique subatomique et des technologies associées ( SUBATECH ), IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Nantes ( UN ), Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique de Clermont ( LPC ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique Nucléaire de Lyon ( IPNL ), Université Claude Bernard Lyon 1 ( UCBL ), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Photon, heavy ion: scattering, 62.4 GeV-cms, Au+Au collisions, General Physics and Astronomy, transverse momentum dependence, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 39 GeV-cms/nucleon62.4 GeV-cms, [ PHYS.NEXP ] Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment (nucl-ex), Nuclear Experiment, 39 GeV-cms/nucleon, Physics, Range (particle radiation), RHIC, Large Hadron Collider, Multiplicative function, PHENIX, nucleus nucleus: colliding beams, PRIRODNE ZNANOSTI. Fizika, photon: direct production, CERN LHC Coll, photon: yield, COLISÕES DE ÍONS PESADOS RELATIVÍSTICOS, quark-gluon plasma, beam energy scan, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 114 Physical sciences, energy dependence, Nuclear physics, direct photons, energy: scaling, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], DILEPTONS, Au+Au collisions, beam energy scan, quark-gluon plasma, direct photons, PHENIX, RHIC, 0103 physical sciences, 010306 general physics, impact parameter: dependence, Scaling, Nuclear Physics, gold, NATURAL SCIENCES. Physics, Yield (chemistry), High Energy Physics::Experiment, Relativistic Heavy Ion Collider, Beam (structure), experimental results
Abstract

The PHENIX collaboration presents first measurements of low-momentum ($0.4$1\,GeV/$c$) direct-photon yield $dN_{\gamma}^{\rm dir}/d\eta$ is a smooth function of $dN_{\rm ch}/d\eta$ and can be well described as proportional to $(dN_{\rm ch}/d\eta)^\alpha$ with $\alpha{\approx}1.25$. This scaling behavior holds for a wide range of beam energies at the Relativistic Heavy Ion Collider and the Large Hadron Collider, for centrality selected samples, as well as for different, $A$$+$$A$ collision systems. At a given beam energy the scaling also holds for high $p_T$ ($>5$\,GeV/$c$) but when results from different collision energies are compared, an additional $\sqrt{s_{_{NN}}}$-dependent multiplicative factor is needed to describe the integrated-direct-photon yield., Comment: 673 authors from 82 institutions, 10 pages, 4 figures. v2 is version accepted for publication in Physical Review Letters. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2019

99. Proton Chelating Ligands Drive Improved Chemical Separations for Rhodium

Author

Peter A. Tasker, Kazuko Morisaku, Mark R. Antonio, Fumiyuki Ito, Ross J. Gordon, William T. Heller, Midori Goto, Ryuhei Motokawa, Emma R. Schofield, Hirokazu Narita, Jason B. Love, Carole A. Morrison, Mikiya Tanaka, Tsuyoshi Yaita, Hideaki Shiwaku, and Rebecca M. Nicolson

Subjects
SOLVENT-EXTRACTION, Inorganic chemistry, chemistry.chemical_element, Hydrochloric acid, 010402 general chemistry, 01 natural sciences, Rhodium, Inorganic Chemistry, Metal, chemistry.chemical_compound, DESIGN, ELEMENTS, SPHERE COORDINATION CHEMISTRY, Physical and Theoretical Chemistry, SPECIATION, Aqueous solution, 010405 organic chemistry, Chemistry, Extraction (chemistry), HCL, 0104 chemical sciences, Leaching (chemistry), SELECTIVITY, NEUTRON-SCATTERING, Reagent, visual_art, visual_art.visual_art_medium, COMPLEXES, CHLORIDE, Selectivity
Abstract

Current methods for the extraction of rhodium carry the highest carbon footprint and worst pollution metrics of all of the elements used in modern technological applications. Improving upon existing methods is made difficult by the limited understanding of the molecular-level chemistry occurring in these processes, particularly in the hydrometallurgical separation step. While many of the precious metals can be separated by solvent extraction, there currently exist no commercial extraction reagents for Rh. This is due to its complicated mixed speciation upon leaching into hydrochloric acid, which gives rise to difficulties in designing effective reagents for solvent extraction. Herein we show that the diamidoamine reagent N-n-hexyl-bis(N-methyl-N-n-octyl-ethylamide)amine transports Rh(III) from aqueous HCl into an organic phase as the mono-aquated dianion [RhCl5(H2O)]2– through the formation of an outer-sphere assembly; this assembly has been characterized by experimentation (slope analysis, FT-IR and NMR spectroscopy, EXAFS, SANS, ESI-MS) and computational modeling. The paper demonstrates the importance of applying a broad range of techniques to obtain a convincing mode of action view for the complex processes involved in anion recognition in the solution phase. A consistent and comprehensive understanding of how the ligand operates to achieve Rh(III) selectivity over the competitor anion Cl− has emerged. This knowledge will guide the rational design of the next generation of extractants and thus offers promise for improving the sustainability of metal extraction from both traditional mining sources and the recycling of secondary source materials.

Published
2019

100. Polynuclear alkoxy-zinc complexes of bowl-shaped macrocycles and their use in the copolymerisation of cyclohexene oxide and CO2

Author

Charlotte K. Williams, Shyeni Paul, James R. Pankhurst, Yunqing Zhu, and Jason B. Love

Subjects
chemistry.chemical_classification, 010405 organic chemistry, chemistry.chemical_element, Polymer, Zinc, 010402 general chemistry, Polypyrrole, 01 natural sciences, 0104 chemical sciences, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, visual_art, Polymer chemistry, Alkoxy group, visual_art.visual_art_medium, Polycarbonate, Selectivity, Cyclohexene oxide
Abstract

The reactions between alcohols and the tetranuclear ethyl-Zn complexes of an ortho-phenylene-bridged polypyrrole macrocycle, Zn4Et4(L1) 1 and the related anthracenyl-bridged macrocyclic complex, Zn4Et4(THF)4(L2) 2 have been studied. With long-chain alcohols such as n-hexanol, the clean formation of the tetranuclear hexoxide complex Zn4(OC6H13)4(L1) 3 occurs. In contrast, the use of shorter-chain alcohols such as i-propanol results in the trinuclear complex Zn3(μ2-OiPr)2(μ3-OiPr)(HL1) 4 that arises from demetalation; this complex was characterised by X-ray crystallography. The clean formation of these polynuclear zinc clusters allowed a study of their use as catalysts in the ring-opening copolymerisation (ROCOP) reaction between cyclohexene oxide and CO2. In situ reactions involving the pre-catalyst 1 and n-hexanol formed the desired polymer with the best selectivity for polycarbonate (90%) at 30 atm CO2, whilst the activity and performance of pre-catalyst 2 was poor in comparison.

Published
2019

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