159 results on '"Aygün, Fatih"'
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52. Hemodiafiltration in Treatment of a Patient with Hypercalcemia and Acute Lymphoblastic Leukemia
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Aygün, Fatih, primary, Koç, Başak, additional, Aygün, Fatma Deniz, additional, Özdemir, Gül Nihal, additional, Zülfükar, Bülent, additional, and Çam, Halit, additional
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- 2016
- Full Text
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53. Çocuk hastalarda diyabetik ketoz ve ketoasidoz sırasındaki elektrokardiyografik değişiklikler.
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Aygün, Deniz, Aygün, Fatih, Nişli, Kemal, Baş, Firdevs, and Çıtak, Agop
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ACIDOSIS , *DIABETIC acidosis , *ELECTROCARDIOGRAPHY , *ELECTROLYTES , *HEART conduction system , *INTENSIVE care units , *SEVERITY of illness index , *CHILDREN , *DIAGNOSIS , *THERAPEUTICS - Abstract
Aim: We aimed to study electrocardiographic changes in children with diabetic ketoacidosis and ketosis and to evaluate the relation of the changes with serum electrolyte levels and ketosis. Material and Methods: This study was performed in Istanbul Medical Faculty, Pediatric Emergency and Intensive Care Department between May 2008 and May 2009. The electrocardiographic parameters and QT length of children with diabetic ketoacidosis and ketosis were evaluated at diagnosis and after the treatment. Results: Forty patients were included in the study; 16 (40%) were diagnosed as having diabetic ketosis and 24 (60%) had diabetic ketoacidosis. Twenty-four (60%) patients were male and 16 (40%) were female and the mean age was 9.21±4.71 years (range, 1-16 years). Twelve (30%) cases of diabetic ketoacidosis were mild, three (7.5%) were moderate, and nine (22.5%) were severe. One patient had premature ventricular beats, and four had ST depression. The electrocardiographic parameters were all normal beyond the QTC length prolongation. The mean QTC length was 447±45 ms (380-560 ms) at diagnosis and 418±32 ms (350-500 ms) after treatment. The change in the QTC length was statistically significant. None of the patients had significant electrolyte disturbance and the prolongation of QTc length was not correlated with serum electrolyte levels. The prolongation of QTc length was statistically correlated with anion gap (r=0.33, p=0.03). Conclusions: In our study, we showed QTc length prolongation and the importance of performing electrocardiography during the diagnosis of diabetic ketoacidosis and ketosis. We also demonstrated that ketosis was responsible for the prolongation of QTc length. [ABSTRACT FROM AUTHOR]
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- 2017
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54. The Effect of Preoperative Smoking on Postoperative Cerebrovascular Accidents in Diabetic Patients Undergoing to Coronary Artery Bypass Graft Surgery
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AYGÜN, Fatih
- Subjects
Sigara içmek,koroner krter bypass graftlemesi,serebrovasküler olay,diyabetes mellitus ,Cigarette smoking,coronary arteries,Coronary Artery Bypass Grafting,cerebrovascular accident,diabetes mellitus - Abstract
AMAÇ: Bu çalıșma koroner arter bypass cerrahisi (KABC) uygulanan diyabetik hastalarda gelișebilecek postoperatif serebrovaskü- ler olay (SVO) ile preoperatif sigara içiminin ilișkisini araștırmak için düzenlenmiștir. YÖNTEM: Bu prospektif çalıșmada Ocak 2008 ve Temmuz 2011 tarihleri arasında KABC geçiren 135 hasta yer aldı. Hastalar iki gruba ayrıldılar. Grup 1 sigara içenler (n=17), Grup 2 ise sigara içmeyenlerden olușuyordu (n=118). Postoperatif öngörülen SVO riski için Amerikan Kalp Derneği’nin 2004’de güncellediği ölçüt kullanıldı. Kriterlere göre tahmini postoperatif SVO riski %0,6 ile %2 (bü- tün hastalar için ortalama %1,04±0,4) arasında değiști. Bütün hastalar postoperatif olası SVO’yu tanıyabilmek için ameliyat sonrası 60 günlük takip programına alındılar. SVO açısından belirti, bulgu ya da șüphesi olan hastalar; radyoloji ve nöroloji bölümleri ile ișbirliği altında multi-disipliner yaklașım ve seri kraniyal tomografilerle değerlendirildiler. İstatistiksel analiz Student t, Fischer’in kesinlik, Yates’in düzeltmeli ki-kare testi ve Mann Whitney U testleri kullanılarak yapıldı. P değerinin 0,05’ten küçük olması anlamlı sayıldı. BULGULAR: Katılımcıların 83’ü erkek ve 52’si kadındı. Hem sigara içenlerin (%88,2) hem de içmeyenlerin (%57,6) grubunda erkekler kadınlara göre anlamlı derecede daha fazlaydılar (p< 0,05). Sigara içenler grubundaki erkek oranı, sigara içmeyenler grubundaki erkek oranından da anlamlı derecede fazlaydı (p< 0,05). İnsüline bağımlı DM oranı sigara içenler grubunda %52,9 ve içmeyenler grubunda %30,5’ti, ancak iki grup arası fark istatistiksel olarak anlamalı değildi (p> 0,05). Preoperatif olarak belirlenen tahmini postoperatif SVO oranı, intraoperatif pompa ve çapraz klampleme zamanları açısından gruplar arası anlamlı farklılık saptanmadı (p>0,05). Sigara içenler grubunda iki (%11,8) ve içmeyenler grubunda iki (%1,7) postoperatif SVO gö- rüldü. Postoperatif SVO oranı sigara içenlerde anlamlı derecede yüksekti (p< 0,05). SONUÇ: KABC için kardiyovasküler cerrahi bölümüne bașvurudan önceki son altı ayda sigara içmek, diyabetik hastalarda postoperatif SVO riskini arttırır., AIM: The study was designed to investigate the correlation between preoperative cigarette smoking and postoperative cerebrovascular accidents (CVA) after coronary artery bypass graft (CABG) surgery in diabetic patients. METHODS: This prospective observational study included 135 diabetic patients underwent coronary artery bypass graft surgery between January 2008 and August 2011. The participating patients were divided into two groups as: Group 1 (n=17) smokers and Group 2 (n=118) non-smokers. Preoperative risk analysis for estimating the post operative CVA was performed by using the criteria of American Heart Association (ACC/AHA) updated in 2004. According to the criteria, assumed postoperative CVA risks ranged between 0.6% and 2% (mean rate for all patients was 1.04±0.4%). Until the postoperative 60th day, all patients were integrated in a follow up programme to scan and diagnose a probable CVA. Patients with symptoms, signs and suspicions of CVA were evaluated by a series cranial tomography scanning and a multi-disciplinary approach in conjunction with the departments of radiology and neurology. Statistical analysis was performed using Student’s t test, Fischer’s exact test, Yates’ correction chi-square test and Mann-Whitney U test. A p value < 0.05 was considered statistically signifi cant. RESULTS: There were 83 male and 52 female participants. The number of males was signifi cantly higher than the females in both the smokers (88.2%) and the non-smokers groups (57.6%), (p< 0.05). The rate of the male patients in the smokers group was also signifi cantly higher than the rate of the smokers in the nonsmokers group (p< 0.05). The rate of patients with insulin dependent DM was 52.9% and 30.5% in the smokers and non-smokers group, respectively, however the inter group difference was not signifi cant (p> 0.05). The rate of preoperatively defi ned estimated postoperative CVA risk, intra-operative pump use and crossclamping durations did not show signifi cant differences between the smokers and non-smokers (p> 0.05). There were two postoperative CVA (11.8%) cases in the smokers and two CVA cases in the non-smokers (1.7%) groups. The rate of CVA was signifi cantly higher among the smokers in comparison with the non-smokers (p< 0.05). CONCLUSION: Smoking in the last six months before attending to the department of cardiovascular surgery for isolated CABG surgery increases the risk for post operative CVA in diabetic patients.
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- 2011
55. Investigation of the relationship between Abdominal Aortic Calcified Plaques deter-mined by multidetector computed tomogra-phy (MDCT) and Body Mass Index (BMI)
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Efe, Duran, primary, Acar, Türker, additional, Aygün, Fatih, additional, Yıldız, Melda, additional, and Gemici, Kazım, additional
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- 2015
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56. Relation Between Obstructive Sleep Apnea and Duration of QRS Complex
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Aygün, Fatih, primary
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- 2015
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57. Effects of cardiopulmonary bypass on mediastinal drainage and the use of blood products in the intensive care unit in 60- to 80-year-old patients who have undergone coronary artery bypass grafting
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Aygün, Fatih, primary, Özülkü, Mehmet, primary, and Günday, Murat, additional
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- 2015
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58. Effect of postoperative pleural effusion in patients undergoing on-pump CABG
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Özülkü, Mehmet, primary and Aygün, Fatih, primary
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- 2015
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59. Antiepileptik ilaç kullanan çocuklarda tiroid hormonlarının değerlendirilmesi
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Aygün, Fatih, Aydınlı, Nur, Baş, Firdevs, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı
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Epilepsy ,Thyroid gland ,Hydrocortisone ,Thyroid hormones ,Anticonvulsants ,Children ,Çocuk Sağlığı ve Hastalıkları ,Child Health and Diseases - Abstract
Epilepsi ve onun tedavisinin endokrin sistem üzerine olan etkileri pek çok çalışmacının ilgisini çekmektedir. Çalışmalarda antiepileptik ilaçların hipotalamo-hipofizer ve gonadal aks üzerine etki ettiği bildirilmektedir. Bu çalışma ile antiepileptik ilaçların tiroid ve adrenal fonksiyonlar üzerine etkisinin araştırılması amaçlanmıştır.Bu çalışmada yaşları 3 ay ile14 yaş arasında değişen, fenobarbital (FB), valproik asit (VPA), karbamazepin (KBZ), okskarbazepin (OKZ), topiramat (TPM) ve levelirasetam (LEV) kullanan, 47'si kız ve 59'u erkek toplam 106 epilepsi tanılı çocuk hasta alındı. Bu hastaların klinik ve hormonal verileri retrospektif olarak dosya kayıtlarından elde edildi. Başvuru sırasındaki klinik bulguları yanında, görüntüleme ve EEG bulguları değerlendirilmeye alındı. Başvuru ve izlem sırasında 3,6 ve 9. aylardaki serbest tiroksin(sT4), tiroid situmulan hormon(TSH) ve kortizol düzeyleri tiroid ve adrenal fonksiyonları değerlendirmek için dosya kayıtlarından elde edildi. Klinik ve laboratuar bulguları ile karşılaştırmalar yapıldı.VPA dışındaki antiepileptikleri kullananlarda sT4, TSH, kortizol düzeyleri normal sınırlar içinde ve izlem sırasında da istatistiksel açıdan anlamlı bir değişim gözlenmedi. Buna karşın 9. aydaki izlemde VPA kullananlarda istatistiksel anlamlı TSH yüksekliği bulunmuştur(p=0,007). Ayrıca antiepileptik ilaçların kullanımı serum kortizol düzeyini etkilememiştir. Hastaların elektroensefalografi(EEG) bulguları ile tiroid hormon düzeyleri karşılaştırıldığında EEG'de ağır bozukluğu olan grupta tiroid disfonksiyonu anlamlı olarak sık bulunmuştur(p=0,041). Magnetik rezonans(MR) bulguları ile tiroid hormon düzeyleri karşılaştırıldığında patolojik görüntüleme bulguları olan hastalarda tiroid hormon bozukluğu görülme sıklığı artış göstermemiştir.Çalışmamızda VPA dışındaki antiepileptiklerin kullanımının 9 ay gibi kısa bir dönemde tiroid hormon bozukluğu oluşturmadığı gösterilmiştir. İzlem süresinin uzaması ile fonksiyon bozukluğu ortaya çıkma olasılığının artabileceğini düşünmekteyiz.Çalışmamızın sonuçları ışıgında; antiepileptik ilaç kullanan hastalarda oluşabilecek tiroid disfonksiyonu olasılığına yönelik tiroid hormon düzeyleri özellikle VPA kullanalarda düzenli olarak takip edilmelidir. Ayrıca EEG'de ağır bozukluğu olanlar daha yakından izlenmelidir.Anahtar kelimeler: Epilepsi, antiepileptikler, tiroid hormonları, kortizol. Many researchers are interested in epilepsy and its effects on endocrine system. In some studies, it has been shown that antiepileptic drugs had an effect on hypothalamo-hypophysial and gonadal axis. We aimed to investigate the effects of anti-epileptic drugs on thyroid and adrenal functions in our study.106 children of 47 girls and 59 boys whose ages differed between 3 months and 14 years, taking phenobarbital (PB), valproic acid (VPA), carbamezepin (CBZ), topiramate(TPM) and levericetam (LEV) for epilepsy diagnosis were included in our study. The clinical and hormonal data of these children were collected retrospectively in their hospital file records.Clinical evidence at the time of hospital admissions, imaging and EEG findings were also investigated. During admission and 3, 6 and 9 month follow-up periods, the results of free thyroxin (fT4), thyroid stimulating hormone (TSH) and cortisol levels were collected from the hospital records to evaluate the thyroid and adrenal functions. Clinical and laboratory results were compared.There has been no significant correlation in those taking anti-epileptic drugs except VPA with normal FT4 and cortisol levels. Elevated TSH levels of children taking VPA were statistically significant (p:0,0007) at the time of the 9th month's follow-up. On the other hand, anti-epileptic drug usage had no effects on cortisol levels. When the results of EEG and the thyroid hormon levels compared, there was a significantly increased correlation between serious EEG findings and thyroid disfunction(p:0,041).It was shown no increased correlation between pathological findings of magnetic resonans imaging(MR) and thyroid disfunction.Our study showed that anti-epileptic drugs except VPA didn?t cause any thyroid disfunction in a short time around 9 months. We think existance of thyroid disfunction is probably higher as the follow-up period is expanded.According to our study, thyroid hormone levels should be measured regularly to prevent thyroid disfunction in patients using anti-epileptic drugs, especially in those taking VPA. On the other hand, epileptic patients with severe EEG findings should be followed up frequently.Key words: Epilepsy, anti-epileptics, thyroid hormones, cortisol. 67
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- 2010
60. Preoperatif MPV; KABGO sonrası Serebrovasküler Olay için prediktör olabilir mi?
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Aygün, Fatih, primary, Özülkü, Mehmet, additional, and Günday, Murat, additional
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- 2014
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61. PIC mikrodenetleyicilerle fiziksel bir deneyin kontrolü
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Aygün, Fatih, Karkı, Hamdi Doğan, and Fizik Ana Bilim Dalı
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Fizik ve Fizik Mühendisliği ,PIC ,Physics and Physics Engineering - Abstract
Bu çalışmada, PIC mikrodenetleyiciler kullanılarak fiziksel bir deneyin kontrolü yapıldı. Fiziksel deneyde PIC mikrolarla sayıcı tasarlanarak zaman ölçüldü. Sayıcının programı MikroBasic programıyla yazıldı. Zaman ölçümü yapılarak cismin ortalama yerçekimi ivmesi ve sürtünme katsayısı hesaplandı. In this work, a physical experiment was controlled by PIC microcontroller PIC16F876. In the experiment, The time was measured via the electronic circuit which was projected and programme that was written using MikroBasic by us. After measured the time, we calculated a mean value of the earth gravity and the friction coefficient. 73
- Published
- 2009
62. Investigation of relation between visceral and subcutaneous abdominal fat volumes and calcified aortic plaques via multislice computed tomography
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Efe, Duran, primary, Aygün, Fatih, additional, Acar, Türker, additional, Yildiz, Melda, additional, and Gemici, Kazım, additional
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- 2014
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63. Ani Bebek Ölümünün Kardiyak Nedenleri
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Aygün, Fatih, primary and Köksal, Nilgün, additional
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- 2014
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64. Anaphylactic Shock After First Exposure to Ceftriaxone In a 8-Year-Old Child
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Aygün, Fatih, primary, Aygün, Fatma Deniz, additional, Nepesov, Serdar, additional, Çam, Halit, additional, and Camcıoğlu, Yıldız, additional
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- 2014
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65. Assessment of the Relationship between Non-Alcoholic Fatty Liver Disease and CAD using MSCT
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Efe, Duran, primary and Aygün, Fatih, additional
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- 2013
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66. İnvajinasyon ensefalopatisi: nadir bir olgu sunumu.
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Aygün, Fatih, Avar Aydın, Pınar Özge, Emre, Şenol, Uzunoğlu, Seval Şimşek, Saltık, Sema, and Çam, Halit
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- 2016
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67. Effect of L-arginine on Hemodynamic, Biochemical, and Histopathological Outcomes in a New Zealand Rabbit Model of Renal Ischemia-Reperfusion Injury.
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Özülkü, Mehmet and Aygün, Fatih
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ARGININE , *ISCHEMIA treatment , *TREATMENT of reperfusion injuries , *THERAPEUTICS - Abstract
Objective: In this study, we investigated the effect of L-arginine on hemodynamic, biochemical, and histopathological changes in a rabbit model with renal ischemia. Methods: Forty white New Zealand rabbits were used. The rabbits were divided into two groups as the control group (n=20) and L-arginine group (n=20). They were monitored by cannulating the auricular and femoral arteries. An aortic occlusion catheter was inserted through the contralateral femoral artery and was extended to the distal aspect of the left subclavian artery; it was then inflated, and occlusion was performed for 30 min. All rabbits received 4 mL/kg/h of NaCl infusion during the course of occlusion and within the first 60 min of reperfusion. In the L-arginine group, L-arginine was infused at a dosage of 3 mg/kg/h through the auricular vein during the first 60 min of occlusion and perfusion. Blood samples for biochemical parameters [glucose, lactate, hematocrit, blood urea nitrogen (BUN), and serum creatinine] were obtained in the peri-ischemic period, in the 20th minute of reperfusion, and just before sacrificing (48th hour). A histopathological examination was performed in both renal tissues. Histopathological scoring was performed by taking tubular epithelial cell flattening, brush border loss, cytoplasmic vacuolization, cell necrosis, and tubular lumen obstruction into consideration. All animals were sacrificed 48 h after the procedure. Results: A significant difference was found between the L-arginine and control groups in terms of the hemodynamic outcomes and 48th hour BUN and serum creatinine levels (p<0.05). The histopathological examination revealed a mean score of 3.2±0.89 in the control group and 2.60±0.68 in the L-arginine group (p<0.05) (p=0.022). Conclusion: It can be suggested that L-arginine reduces renal ischemia-reperfusion injury and in particular, the histopathological effects. (JAREM 2016; 6: 24-30) [ABSTRACT FROM AUTHOR]
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- 2016
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68. The treatment of giant abdominal aorta aneurysm with endovascular stent-graft
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Ulucan, Şeref, primary, Keser, Ahmet, additional, Kuzgun, Ahmet, additional, Aygün, Fatih, additional, and Efe, Duran, additional
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- 2012
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69. Thyroid Hormones in Children on Antiepileptic Therapy
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Aygün, Fatih, primary, Ekici, Barış, additional, Aydınlı, Nur, additional, Aydın, Banu Küçükemre, additional, Baş, Firdevs, additional, and Tatlı, Burak, additional
- Published
- 2011
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70. Effect of using pump on postoperative pleural effusion in the patients that underwent CABG.
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Özülkü, Mehmet and Aygün, Fatih
- Subjects
DRUG infusion pumps ,POSTOPERATIVE period ,PLEURAL effusions ,CORONARY artery bypass ,CARDIOVASCULAR surgery ,CARDIOPULMONARY bypass ,PATIENTS - Abstract
Copyright of Brazilian Journal of Cardiovascular Surgery is the property of Sociedade Brasileira de Cirurgia Cardiovascular and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
- Full Text
- View/download PDF
71. Investigation of relation between visceral and subcutaneous abdominal fat volumes and calcified aortic plaques via multislice computed tomography.
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Efe, Duran, Aygün, Fatih, Acar, Türker, Yildiz, Melda, and Gemici, Kazım
- Abstract
Objective The present study investigated effect of subcutaneous fat volume and abdominal visceral fat volume on aortic atherosclerosis via multislice computed tomography. Materials and methods The present study comprised 424 subjects who underwent non-contrast-enhanced abdominal CT in our clinic between June 2012 and June 2013. Using dedicated software visceral fat volume was calculated for each individual and then subcutaneous fat volume was calculated by subtracting visceral fat volume from total fat volume. By dividing visceral fat volume/subcutaneous fat volume participants were assigned to three groups according to their mean visceral fat volume/subcutaneous fat volume: Group 1 consisted of subjects with visceral fat volume/subcutaneous fat volume lower than 0.48 (Group 1 < 0.48); Group 2 consisted of subjects with visceral fat volume/subcutaneous fat volume equal to or higher than 0.48 and lower than 0.69 (0.48 ≤ Group 2 < 0.69); and Group 3 consisted of subjects with visceral fat volume/subcutaneous fat volume equal to or higher than 0.69 (Group 3 ≥ 0.69). Results The mean abdominal aortic calcium scores according to Agatston scoring (au) were 136.8 ± 418.7 au in Group 1, 179.9 ± 463 au in Group 2 and 212.2 ± 486.9 in Group 3, respectively. Conclusions We have demonstrated a significant correlation between visceral fat volume and abdominal aorta atherosclerosis, while there was absence of significant correlation between subcutaneous fat volume and abdominal atherosclerosis. [ABSTRACT FROM AUTHOR]
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- 2015
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72. Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients.
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Aygün, Fatih and Efe, Duran
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NEUTROPHILS , *CALCIUM , *CROSS-sectional imaging , *MEDICAL radiography , *LYMPHOCYTES - Abstract
Objective: The aim of the present study was to investigate the association of neutrophil/ lymphocyte ratio (NLR) with coronary artery calcium score (CACS) and obstructive coronary artery disease (CAD) detected by multislice computed tomography (MSCT) angiography in type 2 diabetes mellitus (T2DM) patients. Methods: Two hundred and ninety-two T2DM patients, who were either asymptomatic or symptomatic (but noncharacteristic) for coronary artery disease (CAD) and underwent MSCT angiography in our clinic between May 2009 and June 2014, were enrolled. All patients were divided into two groups according to their mean NLR values. Patients with NLR ⪡2.05 were assigned to Group 1 and patients with NLR >2.05 were assigned to Group 2. The association of NLR with CACS and obstructive CAD, which were detected by MSCT angiography, was investigated in T2DM patients. Results: According to the Agatston scoring method, the mean CACS was 129.5±209.8 Au in Group 1 and 290.3?±99.6 Au in Group 2 (P<0.001). Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P=0.021). Conclusion: The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ⪡2.05. In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ⪡2.05. [ABSTRACT FROM AUTHOR]
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- 2015
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73. Hiperkalsemi İçin Hemodiyafiltrasyon Uygulanan Akut Lenfoblastik Lösemi Vakası.
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AYGÜN, Fatih, KOÇ, Başak, AYGÜN, Fatma Deniz, ÖZDEMİR, Gül Nihal, ZÜLFÜKAR, Bülent, and ÇAM, Halit
- Abstract
Hypercalcemia is a rarely seen medical emergency in children compared with adults who present with nonspecific symptoms such as loss of appetite, nausea, vomiting, weight loss. Severe hypercalcemia is a rare complication of malignancy in children which can result in a life threatening condition. Herein, we report a H-year -old girl presenting with a mass on her neck and hypercalcemia. Her serum calcium level was 18.4 mg/dL which necessitated biochemical analysis with resultant establishment of diagnosis of pre B acute lymphoblastic leukemia (ALL) and ensuing venovenous hemofiltration treatment for her acute hypercalcemia. Our aim is to remind that malignancies should not be overlooked in the differential diagnosis of pediatric hypercalcemia. [ABSTRACT FROM AUTHOR]
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- 2014
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74. Treatment with enhanced external counterpulsation improves cognitive functions in chronic heart failure patients.
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Kozdağ, Güliz, İşeri, Pervin, Gökçe, Gökçen, Ertaş, Gökhan, Aygün, Fatih, Kutlu, Ayşe, Hebert, Kathy, and Ural, Dilek
- Abstract
Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2013
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75. Clinical effects of enhanced external counterpulsation treatment in patients with ischemic heart failure.
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Kozdağ, Güliz, Ertaş, Gökhan, Aygün, Fatih, Emre, Ender, Kirbaş, Ahu, Ural, Dilek, and Soran, Özlem
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ENHANCED external counterpulsation ,CORONARY heart disease treatment ,HEART failure ,BIOMARKERS ,LONGITUDINAL method ,NATRIURETIC peptides ,CHRONIC diseases - Abstract
Copyright of Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
- Full Text
- View/download PDF
76. Thyroid Hormones in Children on Antiepileptic Therapy.
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Aygün, Fatih, Ekici, Barış, Aydınlı, Nur, Aydın, Banu Küçükemre, Baş, Firdevs, and Tatlı, Burak
- Subjects
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THYROID hormones , *ANTICONVULSANTS , *CHILDHOOD epilepsy , *THYROTROPIN , *RETROSPECTIVE studies , *CARBAMAZEPINE , *ELECTROENCEPHALOGRAPHY - Abstract
The aim of this study was to evaluate the thyroid function alterations in a group of epileptic children taking antiepileptic drugs (AEDs). Patients demographic data and the free throxine (fT4) and thyroid-stimulating hormone (TSH) levels at the beginning of the treatment and at the third, sixth and ninth months of AED treatment were recorded retrospectively. A total of 106 children, 59 males and 47 females, were enrolled in the study. Mean patient age was 3.7 years, ranging between 3 months and 14 years. In total, 54%% of patients were on valproic acid (VPA), 16%% phenobarbital (PB), 14%% were on carbamazepine (CBZ), 6%% were on oxcarbazepine (OXC), 5%% were on levetiracetam, and 5%% were on topiramate therapy. There were no significant differences in average fT4 values between the drug groups. But the mean fT4 levels of the patients on VPA therapy showed a clear decrease within the observation period. No significant difference in average TSH values between the groups was detected in the beginning and in the third and sixth month. However, in the ninth month, a significant increase in TSH values was found in the VPA group ( p == 0.007). In the patients taking VPA, average TSH values rose progressively while staying within normal limits. During follow-up, thyroid dysfunction were found in 21 patients (19.6%%). A statistically significant relationship was found between severe electroencephalography (EEG) findings and thyroid dysfunction ( p == 0.041). It was concluded that epileptic children with severe EEG findings and using VPA could have thyroid dysfunction. These patients should be followed up closely by thyroid function tests during treatment. [ABSTRACT FROM AUTHOR]
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- 2012
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77. Geç Tanı Alan Metil Malonik Asidemi Vakası.
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AYGÜN, Fatih, ZÜBARİOĞLU, Tanyel, AYGÜN, Deniz, ZEYBEK, Çiğdem AKTUĞLU, and ÇAM, Halk
- Abstract
Methylmalonic acidemia (MMA) is an inherited metabolic disorder that results from deficiency of a vitamin B12- dependent enzyme methylmalonyl-CoA mutase. Lack of this enzyme which converts methylmalonil-CoA to succinyl-CoA and hydrolization to methylmalonic acid leads to increased methylmalonic acid levels in blood and urine. Onset of the clinical manifestations can onset in different ages, and forms. Asymptomatic cases up to adulthood have been reported. The most common clinical forms can be enumerated as acute metabolic decompensation state beginning in the neonatal period, acute intermittant form with asymptomatic intervals between acute episodes and chronic progressive form characterized by hypotonus, developmental, and neuromotor retardation. Herein, we report a 18 month-old female patient diagnosed as late- onset methylmalonic acidemia presenting with neuromotor retardation and convulsion. [ABSTRACT FROM AUTHOR]
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- 2015
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78. İlk Doz Seftriakson Kullanımı Sonrası Anafilaktik Şok Gelişimi.
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AYGÜN, Fatih, ÇAM, Halit, AYGÜN, Fatma Deniz, NEPESOV, Serdar, and CAMCIOĞLU, Yıldız
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In recent years there are threatening reports about allergic reactions and frequent usage of cephalosporins Fatal anaphylaxis after first exposure to cephalosporin is very rare (I ; 100 000). Herein, we report development of anaphylaxis after the first intravenous injection of ceftriaxone in a 8 year- old- male patient who was healthy and did not use ceftriaxone before. We reported this case in order to warm clinicians against the possible risk of anaphylaxis even after the first dose of ceftriaxone and to avoid administration of the drug without indication. [ABSTRACT FROM AUTHOR]
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- 2014
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79. Dev abdominal aorta anevrizmasının endovasküler stent-greft ile tedavisi.
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Ulucan, Şeref, Keser, Ahmet, Kuzgun, Ahmet, Aygün, Fatih, and Efe, Duran
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AORTIC aneurysm treatment ,ABDOMINAL aorta ,ENDOVASCULAR surgery ,SURGICAL stents ,ARTERIAL grafts ,ABDOMINAL surgery - Abstract
Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2012
- Full Text
- View/download PDF
80. Çocuklarda COVID-19.
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Evliyaoğlu, Olcay, Kılınç, Ayşe Ayzıt, Önal, Pınar, Aygün, Fatih, and Çokuğraş, Haluk
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- 2020
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81. Geç Tanı Alan Metil Malonik Asidemi Vakası
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AYGÜN, Fatih, ZÜBARİOĞLU, Tanyel, AYGÜN, Deniz, AKTUĞLU ZEYBEK, Çiğdem, and ÇAM, Halit
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Metilmalonik asidemi,nöromotor retardasyon,geç tanı ,Methylmalonic acidemia,neuromotor retardation,late- onset - Abstract
Metilmalonik asidemi MMA , B12 bağımlı bir enzim olan metilmalonil-KoA mutaz enziminin eksikliğinin yol açtığı bir metabolik hastalıktır. Metilmalonil-KoA’nın süksinilKoA’ya dönüşümünü sağlayan bu enzimin yokluğu metilmalonil-Koa birikimi, kan ve idrarda belirgin düzeyde artmış metilmalonik asit atılımı ile sonuçlanmaktadır. Hastalığın klinik bulguları farklı yaşlarda ve formlarda ortaya çıkabilir, erişkin döneme kadar asemptomatik vakaların olduğu bildirilmiştir. Sık görülen klinik formlar yenidoğan döneminde başlangıç gösteren akut metabolik dekompanzasyon tablosu, ataklar arasındaki dönemde yakınmanın olmadığı akut intermittan form ve hipotoni, gelişme geriliği ve nöromotor retardasyon ile karakterize kronik progresif tablo olarak sayılabilir. Bu makalede nöromotor gelişimi geri olan, nöbet geçirme yakınması ile başvuran ve metilmalonik asidemi teşhisi konulan 18 aylık bir kız hasta geç tanı alması nedeniyle sunulmuştur., Methylmalonic acidemia MMA is an inherited metabolic disorder that results from deficiency of a vitamin B12- dependent enzyme methylmalonyl-CoA mutase. Lack of this enzyme which converts methylmalonil-CoA to succinyl-CoA and hydrolization to methylmalonic acid leads to increased methylmalonic acid levels in blood and urine. Onset of the clinical manifestations can onset in different ages, and forms. Asymptomatic cases up to adulthood have been reported. The most common clinical forms can be enumerated as acute metabolic decompensation state beginning in the neonatal period, acute intermittant form with asymptomatic intervals between acute episodes and chronic progressive form characterized by hypotonus, developmental, and neuromotor retardation. Herein, we report a 18 month- old female patient diagnosed as late- onset methylmalonic acidemia presenting with neuromotor retardation and convulsion.
82. Hiperkalsemi İçin Hemodiyafiltrasyon Uygulanan Akut Lenfoblastik Lösemi Vakası
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AYGÜN, Fatih, KOÇ, Başak, AYGÜN, Fatma Deniz, ÖZDEMİR, Gül Nihal, ZÜLFÜKAR, Bülent, and ÇAM, Halit
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Hypercalcemia,child,acute lymphoblastic leukemia ,Hiperkalsemi,çocuk,akut lenfoblastik lösemi - Abstract
Hiperkalsemi çocuklarda yetişkinlere göre daha az görü- len, genellikle bulantı-kusma, kilo kaybı, iştahsızlık gibi özgün olmayan belirtiler gösteren acil bir tıbbi durumdur. Şiddetli hiperkalsemi, çocuklarda malignitenin ender bir komplikasyonudur ve yaşamı tehdit edecek kadar ciddi olabilir. Bu makalede boynunda kitle yakınmasıyla başvu- ran, biyopsi sonrası kontrol biyokimyasında serum kalsi- yum düzeyinin 18.4 mg/dL saptanması üzerine yapılan incelemeler sonucu Pre B akut lenfoblastik lösemi ALL tanısı alan ve akut hiperkalsemisi için venövenöz hemodi- yafiltrasyon uygulanan 11 yaşında kız hasta sunulmuştur. Amacımız çocuklarda hiperkalsemi ayırıcı tanısında malig- nitenin unutulmaması gerektiğini anımsatmaktadır, Hypercalcemia is a rarely seen medical emergency in child- ren compared with adults who present with nonspecific symptoms such as loss of appetite, nausea, vomiting, weight loss. Severe hypercalcemia is a rare complication of malig- nancy in children which can result in a life threatening con- dition. Herein, we report a 11- year -old girl presenting with a mass on her neck and hypercalcemia. Her serum calcium level was 18.4 mg/dL which necessitated biochemical analy- sis with resultant establishment of diagnosis of pre B acute lymphoblastic leukemia ALL and ensuing venovenous hemofiltration treatment for her acute hypercalcemia. Our aim is to remind that malignancies should not be overlooked in the differential diagnosis of pediatric hypercalcemia
83. Catheterization in the Pediatric Intensive Care Unit: Is it Safe?
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AYGÜN, Fatih, AYGÜN, Deniz, and KAÇAR, Alper
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Catheter,Child,Complication ,Kateter,Çocuk,Komplikasyon - Abstract
Objective: Intravascular catheters are being increasingly used both in intensive care units and inpatient care for the management of children. Herein, we aimed to determine the risk factors and the complications associated with the intravascular catheter placement.Material and Methods: The medical records of 262 patients hospitalized in Okmeydanı Training and Research Hospital’s Pediatric Intensive Care Department between October 2016 and June 2017 were evaluated retrospectively. The demographic data, indications for catheterization, the location and duration of catheterization, the complications including the rate of infection, and the reasons for removing the catheters were evaluated.Results: A total of 148 intravascular catheters were placed for 123 patients. We found that 57 catheters 38.5% had been used in female and 91 61.5% in male patients. The age range was 3 days to 17 years and the weight range 2.2 to 75 kilograms. The mean age at catheter insertion was 4.0±5.0 years. Signs of infection at presentation were present in 115 patients 77.7% . The reasons for catheterization were lack of vascular access in 83 56.1% patients, hemodialysis in 26 17.6% patients and replacement of drugs and fluids in 39 26.4% patients. Access sites were the femoral vein 63.5% and jugular vein 36.5% Urgent catheterization was required for 112 75.7% catheters. Noninfectious complications developed in 3 patients 2.1% . We did not experience any death during catheterization. Catheter sepsis developed in 2 patients 1.4% . The rate of infection was 1.6 for 1000 catheter days. A total of 124 catheters 83.8% were removed as they were no longer required. Conclusion: The expertise of the doctor performing the procedure and nursing care are important factors in reducing the complication rate of catheterization., Amaç: Damar içi kateter yerleştirilmesi gerek yoğun bakım üniteleri gerekse servislerde hasta çocukların yönetiminde giderek artan sıklıkta kullanılmaktadır. Çalışmada amaç, çocuk yoğun bakım hastalarında kateter yerleştirilmesi ile ilişkili komplikasyonlar ve risklerin değerlendirilmesidir. Gereç ve Yöntemler: 15 Ekim 2016 ile 15 Haziran 2017 tarihleri arasında Okmeydanı Eğitim ve Araştırma Hastanesi, Çocuk Yoğun Bakım Ünitesinde yatan 262 hastanın dosyası geriye dönük incelendi. Kateter takılan hastaların demografik bulguları, kateter takılma endikasyonları, takılma yeri ve kalış süresi, kateter takılma sırasında ve sonrasında gelişen komplikasyonlar, enfeksiyon oranları ve kateterin çekilme nedeni incelendi. Bulgular: Hastaların 123’üne toplam 148 adet kateter yerleştirildi. Kateterlerin 57’si %38,5 kız, 91’i %61,5 erkek hastaya takıldı. Hastaların yaş dağılımları 3 gün ile 17 yaş arasında olup ortalama kateter takılma yaşı 4,0±5,0 yıldı. Hastaların tartıları 2,2 ile 75 kilogram arasında idi. Hastaların 115’inde %77,7 başvuru anında enfeksiyon vardı. Takılma nedenlerinden en sık üç neden 83 %56,1 hastada damar yolu bulunamaması, 26’sında %17,6 hemodiyaliz uygulanması ve 39’unda %26,4 ilaç ve sıvı tedavisi idi. Hastalara takılan kateterlerin 94’ü %63,5 femoral ve 54’ü %36,5 jugulerdi. Kateterlerin 112’si %75,7 acil şartlarda takıldı. Hastaların 3’ünde %2,1 enfeksiyon dışı komplikasyon gözlendi. Kateter takılma sırasında ölen hastamız olmadı. Hastaların 2’sinde %1,4 kateter sepsisi gelişti. Bin kateter gününe düşen kateter enfeksiyon sıklığı ise 1,6 olarak hesaplandı. Kateterlerin 124’ü %83,8 gereksinimin ortadan kalkması nedeniyle çekildi.Sonuç: Çocuk hastalarında önem taşıyan kateterin tecrübeli kişiler tarafından yerleştirilmesi ve bakımı ile komplikasyon oranları azaltılabilmektedir
84. Attention to Headache in Children: Two Case with Hypertension and Cerebellar Hemorrhage
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OĞUZ, Fatma, AYGÜN, Fatih, ÜNÜVAR, Ayşegül, AKINCI, Nurver, KILIÇ, Ayşe, TATLI, Burak, ÜNÜVAR, Emin, and SIDAL, Müjgan
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Headache,hypertension,intracranial hemorrhage,chronic immun thrombocytopenic purpura ,Baş ağrısı,hipertansiyon,intrakranial kanama,kronik immun trombositopenik purpura - Abstract
Headache is one of the most commonly seen pain in child- hood. Headache prevalence is approximately 50 % in the first seven years and almost 75-80 % of children experien- ce once until 15 years old. Headache can be primary such as migrane or ıt can be secondary to a serious disease such as intracranial bleeding or intracranial tumors. The cause of chronic and repeating one is mostly due to benign dise- ases, it can be migrane or tension type headache; but also it can occur secondary to systemic diseases, intracranial infections or intracranial bleeding. Two patients admitted with headache will be presented, intended to draw attenti- on to issues. A boy who was diagnosed to have hypertensi- on at age of 15 with chronical headaches repeating since his age of 7 and 10-year-old girl with chronical immune thrombocytopenic purpura who suffered headaches for 3 weeks and was diagnosed cerebellar hematome have been represented in this study. Headache in children who were admitted to the clinic with acute, chronic and primary, secondary headache patients approached the distinction should be made, stories and detailed examination of syste- mic importance should be given, Baş ağrısı çocukluk çağında en sık görülen ağrılardan biridir. Yedi yaşından küçük çocuklarda baş ağrısı preve- lansı % 50’lere varan oranlardadır ve 15 yaşındaki çocukların % 75-80’i en az bir kez baş ağrısı ile tanışmış- tır. Baş ağrısı migren gibi primer nedenlere bağlı olabildi- ği gibi, intrakranial tümör veya kanama gibi daha ciddi sekonder nedenlerlede ortaya çıkabilir. Ayrıca, çocuklar- daki kronik ve yineleyen baş ağrıları çoğunlukla migren ve gerilim tipi gibi selim nedenlere bağlı olmakla beraber, santral sinir sistemi infeksiyonları, sistemik hastalıklar veya kafaiçi basınç artışı gibi ciddi organik durumlarda da ortaya çıkabilir. Baş ağrısı ile başvuran iki vaka sunula- rak, konuya dikkat çekmek amaçlanmıştır. Bu makalede 7 yaşından beri yineleyen kronik baş ağrıları olan ve ancak 15 yaşında hipertansif olduğu anlaşılan erkek hasta ile 3 haftadır baş ağrısı yakınması ile başvuran ve serebellar hematom tanısı almış 10 yaşındaki kronik immun trombo- sitopenik purpuralı kız hasta sunuldu. Baş ağrısı ile polik- liniğe başvuran çocuklarda akut, kronik ve primer, sekon- der baş ağrısı ayırımı yapılarak hastalara yaklaşılmalı; öykü ve ayrıntılı sistemik muayeneye önem verilmelidir
85. Is Gamma-Glutamyl Transferase Elevation Associated With Cardiac Failure In Infants With Ventricular Septal Defect?
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AYGÜN, Fatih and İRDEM, Ahmet
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Çocuk yoğun bakım,kalp yetersizliği,karaciğer,ventriküler septal defekt ,Pediatric intensive care,cardiac failure,liver,ventricular septal defect - Abstract
Purpose/Aim: Ventricular septal defect VSD which is the most common cause of congenital heart defects in children, can lead to heart failure 6–8 weeks after birth due to the decrease in the pulmonary vascular resistance. The clinical features of cardiac failure can be subtle during the infant period, so the laboratory parameters can help the diagnosis and the follow-up. The relation between gamma-glutamyl transferase GGT and cardiac failure is reported in adults. Herein, we aimed to evaluate the relationship between liver enzymes especially GGT levels and cardiac failure developing due to VSD in pediatric patients, Amaç: Doğuştan kalp hastalıkları içinde en sık görüleni olan ventriküler septal defekt VSD doğumdan 6–8 hafta sonra pulmoner vasküler direncinde azalmasıyla birlikte kalp yetersizliğine neden olabilir. Kalp yetersizliği klinik bulguları özellikle bebeklerde silik olabilir. Bu nedenle tanısı ve takibinde laboratuvar değerlerinden faydalanılır. Yetişkin hastalarda gama-glutamil transferaz GGT ile kalp yetersizliği arasında ilişki gösterilmiştir. Biz de bu çalışma ile VSD nedeniyle kalp yetersizliği gelişen hastalarda karaciğer enzimlerini, özellikle GGT düzeyini değerlendirmeyi amaçladık
86. Çok Düşük Doğum Ağırlıklı Bebeklerde Major Mortalite ve Morbidite Nedeni; Patent Duktus Arteriozus
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AYGÜN, Fatih, KÖKSAL, Nilgün, BOSTAN, Özlem M., UYSAL, Fahrettin, VARAL, İpek Güney, and DOĞAN, Pelin
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congenital, hereditary, and neonatal diseases and abnormalities ,Patent duktus arteriozus,preterm,ibuprofen ,Patent ductus arteriosus,preterm,ibuprofen - Abstract
Introduction: Patent Ductus Arteriosus PDA , a cardiac pathology commonly seen inpreterm infants, has negative effects on mortality and morbidity. Persistent patency ofPDA is positively correlated with respiratory distress syndrome RDS , prolongedrespiratory support, pulmonary hemorrhage, broncopulmonary dysplasia BPD ,necrotizing enterocolitis NEC , intraventricular hemorrhage, renal failure,neurodevelopmental impairment cerebral palsy , retinopathy of prematurity and death.The standard treatment regimen is to close symptomatic PDA and cyclooxygenaseinhibitors such as indomethacin, ibuprofen are the first choises. Our aim in this study isto report PDA rate, treatment and complications in premature infants. Materials and Methods: This study retrospectively enrolled 103 infants born, Giriş: Patent duktus arteriozus PDA , preterm yenidoğanlarda sıklıkla karşılaşılan,morbidite ve mortalite üzerine olumsuz etkileri olan kardiyak bir patolojidir. PDA’nın açıkkalması ile respiratuvar distres sendromu RDS , uzamış respiratör desteği, pulmonerhemoraji, bronkopulmoner displazi BPD , nekrotizan enterokolit NEK , intraventrikülerkanama İVK , renal yetmezlik, nörogelişimsel kusur serebral palsi , prematureretinopatisi ROP ve ölüm arasında anlamlı ilişki vardır. Semptomatik PDA’larınkapatılması standart hale gelmiş ve ilk tercih indometazin ve ibuprofen İBU gibisiklooksijenaz inhibitorleri olmuştur. Bu çalışmada preterm bebeklerde PDA sıklığı,tedavisi ve komplikasyonlarının araştırılması amaçlanmıştır.Gereç ve Yöntem: Ocak 2010 ile Kasım 2011 tarihleri arasında 33 hafta ve öncesindedoğan, konjenital major anomalisi veya konjenital kalp hastalığı olmayan, ilk hafta içindeekokardiyografisi EKO yapılmış 103 bebek retrospektif olarak değerlendirildi. PDA’ylailişkili pulmoner hemoraji, NEK, BPD, ROP ve ölüm oranları incelendi.Bulgular: Çalışmada 103 bebeğin 45’i erkek ve 58’i kızdı. Yetmiş bebek sezeryan, 33 bebeknormal doğumla doğmuştu. Bebeklerin gestasyonel haftası ortalama 29,7±2,2, PDA’sıaçık grupta gebelik haftası daha düşük olup 28,8±2,3 hafta idi. Bebeklerin ortalama tartısı1323±375 g idi. Aynı şekilde APGAR skoru ortalama 7,25±1,83 olup PDA’sı açık gruptaanlamlı düşüktü 6,7±1,9 . Doğumdan ortalama 4,8±4,4 gün sonra EKO yapıldı ve 103bebeğin 48 %46 ’inde PDA saptandı. PDA’sı açık olan grupta ortalama doğum tartısı1162±351 g, PDA’sı kapalı grupta ise 1465±340 g bulundu. PDA’sı açık bebeklerdepulmoner hemoraji, NEK, BPD, ROP ve ölüm oranları PDA’sı kapalı olanlarlakarşılaştırıldığında istatistiksel olarak anlamlı ölçüde yüksek bulundu p
87. ÇOCUK YOĞUN BAKIM HASTALARINDA ORTA VE AĞIR HİPONATREMİNİN ERKEN DÖNEM PROGNOZ ÜZERİNE ETKİSİ.
- Author
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Aygün, Fatih and Güvenç, Kübra Boydağ
- Abstract
Copyright of Journal of Pediatric Emergency & Intensive Care Medicine / Çocuk Acil ve Voğun Bakım Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
88. Evaluation of continuous renal replacement therapy and risk factors in the pediatric intensive care unit
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Fatih Aygün, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Aygün, Fatih
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Male ,medicine.medical_specialty ,Continuous Renal Replacement Therapy ,medicine.medical_treatment ,030232 urology & nephrology ,lcsh:Medicine ,030230 surgery ,Intensive Care Units, Pediatric ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Risk of mortality ,Medicine ,Humans ,Renal replacement therapy ,Child ,Retrospective Studies ,Pediatric intensive care unit ,Transplantation ,business.industry ,lcsh:R ,Acute kidney injury ,Infant ,Retrospective cohort study ,Metabolic acidosis ,Odds ratio ,Acute Kidney Injury ,medicine.disease ,Nephrology ,Concomitant ,Child, Preschool ,Emergency medicine ,Female ,Morbidity ,business - Abstract
Aygun, Fatih/0000-0001-6519-6583 WOS:000561254100006 PubMed ID: 32129197 Acute kidney injury (AKI) is one of the most common causes of increased mortality and morbidity in the pediatric intensive care unit (PICU). Continuous renal replacement therapy (CRRT) is the mainstay treatment for AKI in children as it allows continuous and programmed removal of fluids, which is tolerated better hemodynamically. Defining the risk factors of CRRT related to mortality and morbidity will help improve the outcomes of patients in the PICU. In this study, we aimed to determine the prognostic factors and outcomes of patients who received CRRT. This was a single-center, retrospective study on PICU patients requiring CRRT. Patients with a history of chronic renal failure and PICU stay duration of
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- 2020
89. Cardiac causes of sudden ınfant death
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Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bilim Dalı., Aygün, Fatih, and Köksal, Nilgün
- Subjects
Kardiyak neden ,Cardiac causes ,Ani bebek ölümü ,Sudden infant death ,Uzun QT ,İyon kanalı ,Aritmi ,Arrhythmias ,Ion channel ,Long QT - Abstract
Ani bebek ölümü sendromu (ABÖS) halen sebepleri ve mekanizmasıyla sırrını korumaktadır. ABÖS’e neden olan patofizyolojik mekanizma tam olarak anlaşılamamıştır. Yüz üstü pozisyonda uyumanın bu patofizyolojik olaylara katkısının olduğu düşünülmektedir. İlk defa Schwartz tarafından ABÖS ile kalp ve otonom sinir sistemi arasında ilişki olabileceği hipotezi öne sürülmüştür. Konjenital uzun QT sendromunun ventriküler taşiaritmi yaparak bazı ABÖS vakalarının sebebi olabileceği düşünülmektedir. Normal kardiyak ritimden birçok iyon kanalı ve diğer proteinlersorumlu iken, nadir bulunan aritmik bozukluklardan, genetik analizler sonucu, 5 iyon kanalı geni kesinlikle sorumlu tutulmaktadır. Özellikle kardiyak iyon kanallarında mutasyonu olan bebeklerde enfeksiyonlar, ateş, yüzüstü pozisyonda yatma gibi birçok faktörün uzun QT’ye eğilimi arttırdığı düşünülmektedir. Bu derlemede çocukluk çağında ölümlerin önemli bir nedenini oluşturan ve klinisyenlerin nispeten daha az önemsediği ABÖS’e dikkat çekilmek istenmiş ve ABÖS ile uzun QT ilişkisi değerlendirilmiştir. The mechanism and causes of sudden infant death syndrome (SIDS) is still remains its mystery. The pathophysiology of SIDS is not clear. Sleeping in prone position is thought to contribute to pathophysiology. Schwartz was the first physician suggesting that SIDS can be associated with heart and autonomic nervous system. Congenital long QT syndrome may trigger SIDS by causing ventricular tachycardia. Normal cardiac rhythm is regulated by ion channels and specific proteins, but genetical analyses clearly demonstrated that 5 ion channel genes were responsible for rare arrhythmias. The infections, fever and sleeping in prone position can increase the risk of long QT syndrome in babies having mutations in cardiac ion channels. In this review we tried to draw attention to SIDS as an important cause of death in childhood period and association of SIDS with long QT syndrome which is not necessarily noticed by physicians.
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- 2014
90. Çok düşük doğum ağırlıklı bebeklerde major mortalite ve morbidite nedeni; patent duktus arteriozus
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Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Kardiyoloji Bilim Dalı., Aygün, Fatih, Köksal, Nilgün, Bostan, Özlem M., Uysal, Fahrettin, Varal, İpek Günay, and Doğan, Pelin
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congenital, hereditary, and neonatal diseases and abnormalities ,Preterm ,education ,Patent ductus arteriosus ,Ibuprofen ,Patent duktus arteriozus - Abstract
Giriş: Patent duktus arteriozus (PDA), preterm yenidoğanlarda sıklıkla karşılaşılan, morbidite ve mortalite üzerine olumsuz etkileri olan kardiyak bir patolojidir. PDA’nın açık kalması ile respiratuvar distres sendromu (RDS), uzamış respiratör desteği, pulmoner hemoraji, bronkopulmoner displazi (BPD), nekrotizan enterokolit (NEK), intraventriküler kanama (İVK), renal yetmezlik, nörogelişimsel kusur (serebral palsi), premature retinopatisi (ROP) ve ölüm arasında anlamlı ilişki vardır. Semptomatik PDA’ların kapatılması standart hale gelmiş ve ilk tercih indometazin ve ibuprofen (İBU) gibi siklooksijenaz inhibitorleri olmuştur. Bu çalışmada preterm bebeklerde PDA sıklığı, tedavisi ve komplikasyonlarının araştırılması amaçlanmıştır. Gereç ve Yöntem: Ocak 2010 ile Kasım 2011 tarihleri arasında 33 hafta ve öncesinde doğan, konjenital major anomalisi veya konjenital kalp hastalığı olmayan, ilk hafta içinde ekokardiyografisi (EKO) yapılmış 103 bebek retrospektif olarak değerlendirildi. PDA’yla ilişkili pulmoner hemoraji, NEK, BPD, ROP ve ölüm oranları incelendi. Bulgular: Çalışmada 103 bebeğin 45’i erkek ve 58’i kızdı. Yetmiş bebek sezeryan, 33 bebek normal doğumla doğmuştu. Bebeklerin gestasyonel haftası ortalama 29,7±2,2, PDA’sı açık grupta gebelik haftası daha düşük olup 28,8±2,3 hafta idi. Bebeklerin ortalama tartısı 1323±375 g idi. Aynı şekilde APGAR skoru ortalama 7,25±1,83 olup PDA’sı açık grupta anlamlı düşüktü (6,7±1,9). Doğumdan ortalama 4,8±4,4 gün sonra EKO yapıldı ve 103 bebeğin 48 (%46)’inde PDA saptandı. PDA’sı açık olan grupta ortalama doğum tartısı 1162±351 g, PDA’sı kapalı grupta ise 1465±340 g bulundu. PDA’sı açık bebeklerde pulmoner hemoraji, NEK, BPD, ROP ve ölüm oranları PDA’sı kapalı olanlarla karşılaştırıldığında istatistiksel olarak anlamlı ölçüde yüksek bulundu (p
- Published
- 2012
91. Sternotomy with electrocautery and sternal wound infection in congenital heart surgery in patients under 1 year of age.
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Çeli K M, Aygün F, and Özkan M
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- Electrocoagulation, Humans, Retrospective Studies, Risk Factors, Sternotomy adverse effects, Surgical Wound Infection epidemiology, Heart Defects, Congenital surgery, Mediastinitis
- Abstract
Objective: The present study aimed to compare the rate of wound site infection in patients <1 year of age who underwent sternotomy using electrocautery, a routinely performed procedure in our clinic, with those reported in the literature., Methods: This double-center study included patients <1 year of age who underwent cardiac surgery via sternotomy performed with electrocautery for congenital heart disease between January 2017 and June 2019. Patient's data were retrospectively obtained from the hospital records., Results: In our study, seven patients developed SSI, which was superficial in six (1.3%) patients and in the form of mediastinitis in one (0.2%) patient., Conclusion: Sternotomy with electrocautery, which we consider an easy and safe method, was also not found to be statistically different from the other methods in terms of SWI., (© 2021 Wiley Periodicals LLC.)
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- 2021
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92. COVID-19 in children.
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Evliyaoğlu O, Kılınç AA, Önal P, Aygün F, and Çokuğraş H
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- 2020
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93. Electrocardiographic changes in children with diabetic ketoacidosis and ketosis.
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Aygün D, Aygün F, Nişli K, Baş F, and Çıtak A
- Abstract
Aim: We aimed to study electrocardiographic changes in children with diabetic ketoacidosis and ketosis and to evaluate the relation of the changes with serum electrolyte levels and ketosis., Material and Methods: This study was performed in Istanbul Medical Faculty, Pediatric Emergency and Intensive Care Department between May 2008 and May 2009. The electrocardiographic parameters and QT length of children with diabetic ketoacidosis and ketosis were evaluated at diagnosis and after the treatment., Results: Forty patients were included in the study; 16 (40%) were diagnosed as having diabetic ketosis and 24 (60%) had diabetic ketoacidosis. Twenty-four (60%) patients were male and 16 (40%) were female and the mean age was 9.21±4.71 years (range, 1-16 years). Twelve (30%) cases of diabetic ketoacidosis were mild, three (7.5%) were moderate, and nine (22.5%) were severe. One patient had premature ventricular beats, and four had ST depression. The electrocardiographic parameters were all normal beyond the QTC length prolongation. The mean QTC length was 447±45 ms (380-560 ms) at diagnosis and 418±32 ms (350-500 ms) after treatment. The change in the QTC length was statistically significant. None of the patients had significant electrolyte disturbance and the prolongation of QTc length was not correlated with serum electrolyte levels. The prolongation of QTc length was statistically correlated with anion gap (r=0.33, p=0.03)., Conclusions: In our study, we showed QTc length prolongation and the importance of performing electrocardiography during the diagnosis of diabetic ketoacidosis and ketosis. We also demonstrated that ketosis was responsible for the prolongation of QTc length., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
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- 2017
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94. A rare case with encephalopathy.
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Aygün F, Aydın PÖ, Emre Ş, Uzunoğlu SŞ, Saltık S, and Çam H
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- 2016
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95. Effects of Cardiopulmonary Bypass on Mediastinal Drainage and the Use of Blood Products in the Intensive Care Unit in 60- to 80-Year-Old Patients Who Have Undergone Coronary Artery Bypass Grafting.
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Aygün F, Özülkü M, and Günday M
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- Aged, Erythrocyte Transfusion, Female, Hematocrit, Humans, Intensive Care Units, Male, Middle Aged, Plasma, Postoperative Period, Retrospective Studies, Time Factors, Cardiopulmonary Bypass methods, Coronary Artery Bypass, Coronary Artery Bypass, Off-Pump, Drainage statistics & numerical data
- Abstract
Objective: The present study consisted of patients who underwent on-pump coronary artery bypass grafting (CABG) and off-pump CABG and investigated effect of using cardiopulmonary bypass (CPB) on the amount of postoperative drainage and blood products, red blood cell (RBC), free frozen plasma (FFP) given in the intensive care unit in 60-80-year-old patients who underwent CABG., Methods: The present study comprises a total of 174 patients who have undergone coronary artery bypass graft (off-pump or on-pump CABG) surgery in our clinic in between 2012-2015 year., Results: It was observed that the amount of drainage in the first 24 postoperative hours was lower in the on-pump CABG group (Group 1) when compared to off-pump group (Group 2) (Group 1 vs . Group 2; 703.5±253.8 ml vs . 719.6±209.4 ml;P =0.716). However, the amount of drainage in the second 24 hours was statistically significantly lower in the off-pump CABG group (Group 1 vs . Group 2; 259.8±170.6 mlvs . 190.1±129.1 ml; P =0.016). With regard to the amount of overall drainage, no statistically significant difference was observed between the two groups. Group 1 needed RBC transfusion higher than Group 2 (Group 1 vs . Group 2; 2.2±1.3 bag vs . 1.2±0.9 bag;P <0.001)., Conclusion: We can say that CPB influences the amount of second 24-hour drainage which indexed body surface area. In addition, CPB decreases hct, hb, thrombocyte count in ICU arrived, after 24 hours in postoperative period. Reduced thrombocyte counting effect can be appeared after 48 hours in the postoperative period of CPB.
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- 2015
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96. Effect of using pump on postoperative pleural effusion in the patients that underwent CABG.
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Özülkü M and Aygün F
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- Adult, Aged, Aged, 80 and over, Body Mass Index, Coronary Artery Bypass instrumentation, Coronary Artery Bypass, Off-Pump adverse effects, Coronary Artery Bypass, Off-Pump instrumentation, Female, Humans, Incidence, Male, Middle Aged, Patient Discharge, Pleural Effusion etiology, Retrospective Studies, Treatment Outcome, Coronary Artery Bypass adverse effects, Extracorporeal Circulation instrumentation, Pleural Effusion epidemiology, Postoperative Complications epidemiology
- Abstract
Objective: The present study investigated effect of using pump on postoperative pleural effusion in patients who underwent coronary artery bypass grafting., Methods: A total of 256 patients who underwent isolated coronary artery bypass grafting surgery in the Cardiovascular Surgery clinic were enrolled in the study. Jostra-Cobe (Model 043213 105, VLC 865, Sweden) heart-lung machine was used in on-pump coronary artery bypass grafting. Off-pump coronary artery bypass grafting was performed using Octopus and Starfish. Proximal anastomoses to the aorta in both on-pump and off-pump techniques were performed by side clamps. The patients were discharged from the hospital between postoperative day 6 and day 11., Results: The incidence of postoperative right pleural effusion and bilateral pleural effusion was found to be higher as a count in Group 1 (on-pump) as compared to Group 2 (off-pump). But the difference was not statistically significant [P>0.05 for right pleural effusion (P=0.893), P>0.05 for bilateral pleural effusion (P=0.780)]. Left pleural effusion was encountered to be lower in Group 2 (off-pump). The difference was found to be statistically significant (P<0.05, P=0.006)., Conclusion: Under the light of these results, it can be said that left pleural effusion is less prevalent in the patients that underwent off-pump coronary artery bypass grafting when compared to the patients that underwent on-pump coronary artery bypass grafting.
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- 2015
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97. Relationship of coronary artery disease with pericardial and periaortic adipose tissue and their volume detected by MSCT.
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Efe D, Aygün F, Ulucan Ş, and Keser A
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- Aged, Coronary Angiography methods, Diabetes Mellitus epidemiology, Dyslipidemias epidemiology, Female, Humans, Hypertension epidemiology, Male, Middle Aged, Multidetector Computed Tomography methods, Organ Size, Reproducibility of Results, Risk Factors, Smoking epidemiology, Adipose Tissue pathology, Aorta pathology, Coronary Artery Disease diagnosis, Coronary Artery Disease epidemiology, Pericardium pathology
- Abstract
Introduction: The relationship of pericardial and periaortic adipose tissue with coronary artery disease (CAD) and the significance of this relationship were investigated., Methods: The present study included 323 subjects, with or without cardiac symptoms, who underwent multislice computed tomography coronary angiography between May 2009 and January 2013. Patients were divided into two groups according to the mean values of pericardial adipose tissue volume (PCFV) and periaortic adipose tissue volume (PAFV). In the grouping based on PCFV, subjects with PCFV<157.7 cm3 comprised Group 1, and those with PCFV≥157.7 cm³ comprised Group 2. According to PAFV values, Group 1 consisted of subjects with PAFV<24.3 cm³, and Group 2 subjects with PAFV≥24.3 cm³. The relationship of CAD with each of PCFV and PAFV was investigated., Results: Based on PCFV measurements, there were 79 (43.6%) and 113 (79.6%) patients with CAD in Groups 1 and 2, respectively. Based on PAFV measurements, Group 1 comprised 90 (48.1%) and Group 2 comprised 102 (75%) CAD patients., Conclusions: In both groupings, the prevalence of CAD was significantly higher in Group 2 versus Group 1 (p<0.01 for both). There was a significant relationship between CAD and PAFV (p<0.05), but the relation between CAD and PCFV was more significant (p<0.01).
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- 2015
98. The protective effect of topical rifamycin treatment against sternal wound infection in diabetic patients undergoing on-pump coronary artery bypass graft surgery.
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Aygün F, Kuzgun A, Ulucan S, Keser A, Akpek M, and Kaya M
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- Aged, Aged, 80 and over, Cytoprotection, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Risk Factors, Sternum surgery, Treatment Outcome, Antirheumatic Agents pharmacology, Coronary Artery Bypass methods, Diabetes Complications drug therapy, Rifamycins pharmacology, Wound Infection drug therapy
- Abstract
Objectives: The aim of this study was to investigate the protective effect of topical rifamycin SV treatment against sternal wound infection (SWI) in diabetic patients undergoing on-pump coronary artery bypass graft (CABG) surgery., Methods: One hundred and fifty-nine diabetic patients who were scheduled to undergo isolated on-pump CABG surgery were included. Eight were excluded for various reasons. Of the 151 patients, 51 were on insulin therapy and 100 were on oral anti-diabetics. The risk of mediastinitis was assessed using the American College of Cardiology/American Heart Association 2004 guideline update for CABG surgery. According to the risk scores, patients were divided into two comparable groups: the rifamycin group (n = 78) received topical rifamycin treatment after on-pump CABG surgery, and the control group (n = 73) received no topical treatment., Results: Deep sternal wound infection (mediastinitis) was not observed in either group (0/78 vs 0/73, p = 1.0). No superficial sternal wound infection was observed in the rifamycin group, however, it did occur in one patient in the control group (0/78 vs 1/73, p = 0.303). Wound culture was performed and coagulase-negative staphylococci were observed. The infection regressed on initiation of antibiotic therapy against isolated bacteria and the patient was discharged after a full recovery., Conclusions: Although the difference in rate of superficial sternal wound infection (SSWI) in the rifamycin and control groups was not statistically significant, locally applied rifamycin SV during closure of the sternum in the CABG operation may have had a protective affect against SWI.
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- 2014
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99. Assessment of the relationship between non-alcoholic fatty liver disease and CAD using MSCT.
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Efe D and Aygün F
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- Adult, Age Factors, Aged, Chi-Square Distribution, Coronary Artery Disease etiology, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Fatty Liver complications, Female, Humans, Liver diagnostic imaging, Liver pathology, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Risk Factors, Sex Factors, Young Adult, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Fatty Liver diagnostic imaging, Multidetector Computed Tomography methods
- Abstract
Background: Some risk factors for atherosclerosis are followed by non-alcoholic fatty liver disease (NAFLD). We wanted to use Multislice computed tomography (MSCT) as technique for searching relationship between NAFLD and coronary artery disease (CAD)., Objective: The relationship between NAFLD and CAD was investigated using MSCT., Methods: A total of 372 individuals with or without cardiac symptoms who had undergone MSCT angiography were included in the study. The patients were divided into two groups according to the presence of NAFLD. Coronary artery segments were visually evaluated via MSCT angiography. Based on the coronary artery stenosis degree, those with no or minimal plaques were considered normal, whereas those who had stenosis of less than 50% and at least one plaque were considered to have non-obstructive coronary artery disease (non-obsCAD). The patients who had at least one plaque and coronary artery stenosis of 50% or more were considered to have obstructive coronary artery disease (obsCAD). NAFLD was determined according to the MSCT protocol, using the liver density., Results: According to the liver density, the number of patients with non-alcoholic fatty liver disease (group 1) was 204 (149 males, 54.8%) and with normal liver (group 2) was 168 (95 males, 45.2%). There were 50 (24.5%) non-obsCAD and 57 (27.9%) obsCAD cases in Group 1, and 39 (23.2%) non-obsCAD and 23 (13.7%) obsCAD cases in Group 2., Conclusions: The present study using MSCT demonstrated that the frequency of coronary artery disease in patients with NAFDL was significantly higher than that of patients without NAFDL.
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- 2014
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100. Treatment with enhanced external counterpulsation improves cognitive functions in chronic heart failure patients.
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Kozdağ G, Işeri P, Gökçe G, Ertaş G, Aygün F, Kutlu A, Hebert K, and Ural D
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- Age Factors, Aged, Female, Humans, Male, Treatment Outcome, Cognition, Counterpulsation methods, Heart Failure therapy
- Abstract
Objectives: Chronic heart failure (CHF) has been associated with an increased risk of poorer cognitive performance in older adults. Reversibility of cognitive impairment after medical treatment has been reported, although the restorative effects of enhanced external counterpulsation (EECP) on cognitive performance have not been studied. We investigated the effect of EECP on cognitive functions in CHF patients., Study Design: Thirty-six individuals (mean age: 66±8 years) who were diagnosed with CHF and were New York Heart Association (NYHA) Class II-III and Canadian Cardiovascular Society (CCS) Class II-III participated in this study. Neuropsychological assessment was performed in these patients., Results: Patients in the EECP treatment group showed a statistically significant improvement in spontaneous naming (p=0.011) and forward row score of the attention subset among domains of cognition (p=0.020) and interference time of executive function (p=0.012)., Conclusion: Enhanced external counter pulsation resulted in improvement in all domains of cognitive functions except verbal and visual memory tests.
- Published
- 2013
- Full Text
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