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524 results on '"Athale, Uma"'

51. Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia

Author

Lipshultz, Steven E., Lipsitz, Stuart R., Kutok, Jeffery L., Miller, Tracie L., Colan, Steven D., Neuberg, Donna S., Stevenson, Kristen E., Fleming, Mark D., Sallan, Stephen E., Franco, Vivian I., Henkel, Jacqueline M., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Michon, Bruno, Laverdiere, Caroline, Larsen, Eric, Kelly, Kara M., and Silverman, Lewis B.

Published
2013
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52. Corrigendum

Author

Burns, Melissa A., primary, Place, Andrew E., additional, Stevenson, Kristen E., additional, Gutiérrez, Alejandro, additional, Forrest, Suzanne, additional, Pikman, Yana, additional, Vrooman, Lynda M., additional, Harris, Marian H., additional, Weinberg, Olga K., additional, Hunt, Sarah K., additional, O'Brien, Jane E., additional, Asselin, Barbara L., additional, Athale, Uma H., additional, Clavell, Luis A., additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, JustineM., additional, Kelly, Kara M., additional, Laverdiere, Caroline, additional, Leclerc, Jean‐Marie, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Sulis, Maria Luisa, additional, Welch, Jennifer J.G., additional, Neuberg, Donna S., additional, Sallan, Stephen E., additional, and Silverman, Lewis B., additional

Published
2020
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53. Frequency and Prognostic Significance of Recurrent Gene Mutations in Pediatric B-ALL: Report from the DFCI ALL Consortium

Author

Gotti, Giacomo, primary, Puligandla, Maneka, additional, Stevenson, Kristen E., additional, Mar, Brenton G., additional, Asselin, Barbara L, additional, Athale, Uma, additional, Clavell, Luis A., additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, Justine M., additional, Kelly, Kara M., additional, Laverdiere, Caroline, additional, Leclerc, Jean-Marie, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Sulis, Maria L., additional, Tran, Thai Hoa, additional, Welch, Jennifer J.G., additional, Stegmaier, Kimberly, additional, Harris, Marian H., additional, Silverman, Lewis B., additional, and Pikman, Yana, additional

Published
2020
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55. Healthcare Utilization and Costs Associated with Different Treatment Protocols for Newly Diagnosed Childhood Acute Lymphoblastic Leukemia: A Population-Based Study

Author

Gupta, Sumit, primary, Mittman, Nicole, additional, Pechlivanoglou, Petros, additional, Li, Qing, additional, Athale, Uma, additional, Bassal, Mylene, additional, Breakey, Vicky R., additional, Gibson, Paul J., additional, Silva, Mariana, additional, Zabih, Veda, additional, Pole, Jason, additional, and Sutradhar, Rinku, additional

Published
2020
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57. Identification of prognostic factors in childhood T‐cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05‐001 and 11‐001

Author

Burns, Melissa A., primary, Place, Andrew E., additional, Stevenson, Kristen E., additional, Gutiérrez, Alejandro, additional, Forrest, Suzanne, additional, Pikman, Yana, additional, Vrooman, Lynda M., additional, Harris, Marian H., additional, Weinberg, Olga K., additional, Hunt, Sarah K., additional, O'Brien, Jane E., additional, Asselin, Barbara L., additional, Athale, Uma H., additional, Clavell, Luis A., additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, Justine M., additional, Kelly, Kara M., additional, Laverdiere, Caroline, additional, Leclerc, Jean‐Marie, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Sulis, Maria Luisa, additional, Welch, Jennifer J.G., additional, Neuberg, Donna S., additional, Sallan, Stephen E., additional, and Silverman, Lewis B., additional

Published
2020
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65. Outcomes of haemoglobin Bart’s hydrops fetalis following intrauterine transfusion in Ontario, Canada

Author

Zhang, Hui Jue, primary, Amid, Ali, additional, Janzen, Laura A, additional, Segbefia, Catherine I, additional, Chen, Shiyi, additional, Athale, Uma, additional, Charpentier, Karen, additional, Merelles-Pulcini, Manuela, additional, Seaward, Gareth, additional, Kelly, Edmond N, additional, Odame, Isaac, additional, Waye, John S, additional, Ryan, Greg, additional, and Kirby-Allen, Melanie, additional

Published
2020
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66. Protective Effects of Dietary Intake of Antioxidants and Treatment-Related Toxicity in Childhood Leukemia: A Report From the DALLT Cohort

Author

Ladas, Elena J., primary, Blonquist, Traci M., additional, Puligandla, Maneka, additional, Orjuela, Manuela, additional, Stevenson, Kristen, additional, Cole, Peter D., additional, Athale, Uma H., additional, Clavell, Luis A., additional, Leclerc, Jean-Marie, additional, Laverdiere, Caroline, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Greene Welch, Jennifer, additional, Asselin, Barbara L., additional, Sallan, Stephen E., additional, Silverman, Lewis B., additional, and Kelly, Kara M., additional

Published
2020
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69. Utilising red cell antigen genotyping and serological phenotyping in sickle cell disease patients to risk‐stratify patients for alloimmunisation risk

Author

Shih, Andrew W., primary, Yan, Matthew T.S., additional, Elahie, Allahna L., additional, Barty, Rebecca L., additional, Liu, Yang, additional, Berardi, Philip, additional, Azzam, Mona, additional, Siddiqui, Reda, additional, Parvizian, Michael K., additional, Mcdougall, Tara, additional, Heddle, Nancy M., additional, Al‐Habsi, Khalid S., additional, Goldman, Mindy, additional, Cote, Jacqueline, additional, Athale, Uma, additional, and Verhovsek, Madeleine M., additional

Published
2020
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71. Experience with ponatinib in paediatric patients with leukaemia

Author

Rossoff, Jenna, primary, Huynh, Van, additional, Rau, Rachel E., additional, Macy, Margaret E., additional, Sulis, Maria L., additional, Schultz, Kirk R., additional, Burke, Michael J., additional, Athale, Uma, additional, O'Brien, Maureen M., additional, Gregory, John J., additional, Sluis, Inge M., additional, Keller, Frank G., additional, Zwaan, Christian M., additional, Suttorp, Meinolf, additional, and Hijiya, Nobuko, additional

Published
2020
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72. Fluctuations in dietary intake during treatment for childhood leukemia: A report from the DALLT cohort

Author

Ladas, Elena J., primary, Orjuela, Manuela, additional, Stevenson, Kristen, additional, Cole, Peter D., additional, Lin, Meiko, additional, Athale, Uma H., additional, Clavell, Luis A., additional, Leclerc, Jean-Marie, additional, Laverdiere, Caroline, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Welch, Jennifer Greene, additional, Asselin, Barbara L., additional, Sallan, Stephen E., additional, Silverman, Lewis B., additional, and Kelly, Kara M., additional

Published
2019
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74. Genetic Ancestry and Skeletal Toxicities Among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort

Author

Zhu, Qianqian, primary, Yao, Song, additional, Cole, Peter D, additional, Kahn, Justine M., additional, Harris, Marian H., additional, Schiller, Emily, additional, Athale, Uma, additional, Clavell, Luis A., additional, Laverdiere, Caroline, additional, Leclerc, Jean-Marie, additional, Michon, Bruno, additional, Schorin, Marshall A., additional, Welch, Jennifer J.G., additional, Sallan, Stephen E., additional, Silverman, Lewis B., additional, and Kelly, Kara M., additional

Published
2019
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88. Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?

Author

Halton Jacqueline, Nagel Kim, Brandão Leonardo R, Silva Mariana, Gibson Paul, Chan Anthony, Blyth Kay, Hicks Kim, Parmar Nagina, Paddock Leslie, Willing Stephanie, Thabane Lehana, and Athale Uma

Subjects
Central venous line, Central venous line dysfunction, Infection, Thromboembolism, Cancer, Children, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Thromboembolism (TE) and infection are two common complications of central venous line (CVL). Thrombotic CVL-dysfunction is a common, yet less studied, complication of CVL. Two retrospective studies have reported significant association of CVL-dysfunction and TE. Recent studies indicate association of CVL-related small clot with infection. Infection is the most common cause of non-cancer related mortality in children with cancer. We and others have shown reduced overall survival (OS) in children with cancer and CVL-dysfunction compared to those without CVL-dysfunction. Despite these observations, to date there are no prospective studies to evaluate the clinical significance of CVL-dysfunction and it’s impact on the development of TE, infection, or outcome of children with cancer. Study design This is a prospective, analytical cohort study conducted at five tertiary care pediatric oncology centers in Ontario. Children (≤ 18 years of age) with non-central nervous system cancers and CVL will be eligible for the study. Primary outcome measure is symptomatic TE and secondary outcomes are infection, recurrence of cancer and death due to any cause. Data will be analyzed using regression analyses. Discussion The overall objective is to delineate the relationship between CVL-dysfunction, infection and TE. The primary aim is to evaluate the role of CVL-dysfunction as a predictor of symptomatic TE in children with cancer. We hypothesize that children with CVL-dysfunction have activation of the coagulation system resulting in an increased risk of symptomatic TE. The secondary aims are to study the impact of CVL-dysfunction on the rate of infection and the survival [OS and event free survival (EFS)] of children with cancer. We postulate that patients with CVL-dysfunction have an occult CVL-related clot which acts as a microbial focus with resultant increased risk of infection. Further, CVL-dysfunction by itself or in combination with associated complications may cause therapy delays resulting in adverse outcome. This study will help to identify children at high risk for TE and infection. Based on the study results, we will design randomized controlled trials of prophylactic anticoagulant therapy to reduce the incidence of TE and infection. This in turn will help to improve the outcome in children with cancer.

Published
2012
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89. Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol

Author

Balakumaran, Janatani, primary, Birk, Tanisha, additional, Golemiec, Breanne, additional, Helmeczi, Wryan, additional, Inkaran, Jeyanth, additional, Kao, Yun-ya, additional, Leigh, Jennifer, additional, Saliba, Sarah, additional, Sharma, Rishi, additional, Spatafora, Laura, additional, Wright, Kristin, additional, Yao, William, additional, Hillis, Christopher, additional, Banfield, Laura, additional, Thabane, Lehana, additional, Athale, Uma, additional, and Samaan, M Constantine, additional

Published
2019
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90. Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group

Author

Athale, Uma, primary, Hijiya, Nobuko, additional, Patterson, Briana C., additional, Bergsagel, John, additional, Andolina, Jeffrey R., additional, Bittencourt, Henrique, additional, Schultz, Kirk R., additional, Burke, Michael J., additional, Redell, Michele S., additional, Kolb, E. Anders, additional, and Johnston, Donna L., additional

Published
2019
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91. Efficacy and toxicity of pegaspargase and calaspargase pegol in childhood acute lymphoblastic leukemia/lymphoma: Results of DFCI 11-001.

Author

Vrooman, Lynda M., primary, Blonquist, Traci M., additional, Supko, Jeffrey G., additional, Hunt, Sarah K., additional, O'Brien, Jane E., additional, Kay-Green, Samantha, additional, Athale, Uma H., additional, Clavell, Luis Antonio, additional, Cole, Peter D., additional, Harris, Marian H., additional, Kelly, Kara M., additional, Laverdiere, Caroline, additional, Leclerc, Jean-Marie, additional, Michon, Bruno, additional, Welch, Jennifer JG, additional, Stevenson, Kristen E., additional, Neuberg, Donna S., additional, Sallan, Stephen E., additional, and Silverman, Lewis B., additional

Published
2019
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92. High Vs. Low-Intensity Bridging Chemotherapy in Children with Acute Lymphoblastic Leukemia Awaiting Chimeric Antigen Receptor T-Cell Therapy: A Population-Based Study from Ontario, Canada

Author

Gupta, Sumit, primary, Alexander, Sarah, additional, Zupanec, Sue, additional, Athale, Uma, additional, Bassal, Mylene, additional, Edwards, Ethan, additional, Gibson, Paul J., additional, Johnston, Donna, additional, Marjerrison, Stacey, additional, Zorzi, Alexander, additional, Hitzler, Johann K., additional, Naqvi, Ahmed, additional, Punnett, Angela, additional, Whitlock, James A., additional, Grupp, Stephan A., additional, Maude, Shannon L., additional, and Krueger, Joerg, additional

Published
2018
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94. Increasing Incidence and Prevalence of Pathologic Hemoglobinopathies Among Children in Ontario, Canada from 1991-2013

Author

Simpson, Ewurabena, primary, Klaassen, Robert J, additional, Chakraborty, Pranesh, additional, Potter, Beth, additional, Kirby-Allen, Melanie Ann, additional, Odame, Isaac, additional, Williams, Suzan, additional, Athale, Uma, additional, Jardine, Lawrence, additional, Gibson, Paul J., additional, Silva, Mariana, additional, Merelles-Pulcini, Manuela, additional, Bowerman, Brooke, additional, Petrcich, William, additional, and Benchimol, Eric I, additional

Published
2018
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96. Outcomes of haemoglobin Bart's hydrops fetalis following intrauterine transfusion in Ontario, Canada.

Author

Hui Jue Zhang, Amid, Ali, Janzen, Laura A., Segbefia, Catherine I., Shiyi Chen, Athale, Uma, Charpentier, Karen, Merelles-Pulcini, Manuela, Seaward, Gareth, Kelly, Edmond N., Odame, Isaac, Waye, John S., Ryan, Greg, Kirby-Allen, Melanie, Zhang, Hui Jue, and Chen, Shiyi

Subjects
HYDROPS fetalis, WECHSLER Intelligence Scale for Children, HEMOGLOBINS, CHILD patients
Abstract

Objectives: With improved access to intrauterine transfusion (IUT), more fetuses with haemoglobin Bart's hydrops fetalis (HBHF; homozygous α0-thalassaemia) will survive.Design: To evaluate the long-term outcome of affected fetuses with and without IUT in Ontario, Canada, we retrospectively collected data on IUTs and pregnancy outcomes in all cases of HBHF, from 1989 to 2014. Clinical outcome and neurocognitive profiles of long-term survivors were also collected and compared with data from 24 patients with transfusion-dependent β-thalassaemia (TDT-β).Results: Of the 99 affected pregnancies (93 prenatally diagnosed), 68 resulted in miscarriage or elective termination of pregnancy. Twelve mothers (12%) continued their pregnancies without IUT, and none of those newborns survived the first week of life. All 13 fetuses that received IUT(s) were live-born, but 3 died due to severe hydrops at birth and 1 died due to infection. The remaining nine survivors, in comparison with TDT-β patients, had earlier iron overload requiring iron chelation therapy. Endocrinopathies and short stature were more frequent in these patients. Neurocognitive outcome was not significantly affected in five patients who were assessed, and none were diagnosed with intellectual impairment. In three patients, MRI studies demonstrated brain white matter changes in keeping with 'silent' ischaemic infarcts.Conclusions: In patients with HBHF, IUT is associated with improved survival. While acceptable neurocognitive outcome can be expected, these patients have more clinical complications compared with their TDT-β counterparts. The clinical and neurocognitive outcomes of HBHF should be discussed in detail when counselling and offering IUT for patients. [ABSTRACT FROM AUTHOR]

Published
2021
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97. Identification of prognostic factors in childhood T‐cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05‐001 and 11‐001.

Author

Burns, Melissa A., Place, Andrew E., Stevenson, Kristen E., Gutiérrez, Alejandro, Forrest, Suzanne, Pikman, Yana, Vrooman, Lynda M., Harris, Marian H., Hunt, Sarah K., O'Brien, Jane E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Gennarini, Lisa M., Kahn, Justine M., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean‐Marie, and Michon, Bruno

Published
2021
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99. Influence of HIV epidemic on the incidence of Kaposi's sarcoma in Zambian children

Author

Athale, Uma H., Patil, P.S., Chintu, C., and Elem, B.

Subjects
Zambia -- Health aspects, Kaposi's sarcoma -- Demographic aspects, HIV infection -- Complications, Health
Abstract

The incidence of Kaposi's sarcoma in Zambian children has increased dramatically since 1981. Researchers reviewed the records of all pediatric KS cases seen at Zambia's University Teaching Hospital since 1981. In that period, the hospital recorded 85 pediatric KS cases. There were no cases in 1981, but the number of cases gradually increased, especially after 1987. Before 1986, pediatric KS represented six percent of all childhood cancers on average. Between 1987 and 1992, it averaged 19% of all childhood cancers. More than half of the children with KS were less than five years old. In almost 79% of the cases, the primary lesion was in the lymph nodes. The average survival following diagnosis was 13 weeks.

Published
1995

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