534 results on '"Asehnoune K"'
Search Results
52. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
- Author
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Reignier, J., Boisrame-Helms, J., Brisard, L., Lascarrou, J. B., Ait Hssain, A., Anguel, N., Argaud, Laurent, Asehnoune, K., Asfar, P., Bellec, F., Botoc, V., Bretagnol, A., Bui, H. N., Canet, E., Da Silva, D., Darmon, M., Das, V., Devaquet, J., Djibre, M., Ganster, F., Garrouste-Orgeas, M., Gaudry, S., Gontier, O., Guerin, C., Guidet, B., Guitton, C., Herbrecht, J. E., Lacherade, J. C., Letocart, P., Martino, F., Maxime, V., Mercier, E., Mira, J. P., Nseir, S., Piton, G., Quenot, J. P., Richecoeur, J., Rigaud, J. P., Robert, R., Rolin, N., Schwebel, C., Sirodot, M., Tinturier, F., Thevenin, D., Giraudeau, B., Le Gouge, A., Investigators, Nutrirea- Trial, Intensive, Care, Sepsis, group, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,Adult ,Enteral Nutrition ,Shock/complications/mortality/*therapy ,Time Factors ,Respiration ,[SDV]Life Sciences [q-bio] ,Vasoconstrictor Agents/therapeutic use ,Length of Stay ,Middle Aged ,Critical Care ,Treatment Outcome ,Artificial ,Humans ,Female ,Hospital Mortality ,Parenteral Nutrition ,Aged - Abstract
BACKGROUND: Whether the route of early feeding affects outcomes of patients with severe critical illnesses is controversial. We hypothesised that outcomes were better with early first-line enteral nutrition than with early first-line parenteral nutrition. METHODS: In this randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2 trial) done at 44 French intensive-care units (ICUs), adults (18 years or older) receiving invasive mechanical ventilation and vasopressor support for shock were randomly assigned (1:1) to either parenteral nutrition or enteral nutrition, both targeting normocaloric goals (20-25 kcal/kg per day), within 24 h after intubation. Randomisation was stratified by centre using permutation blocks of variable sizes. Given that route of nutrition cannot be masked, blinding of the physicians and nurses was not feasible. Patients receiving parenteral nutrition could be switched to enteral nutrition after at least 72 h in the event of shock resolution (no vasopressor support for 24 consecutive hours and arterial lactate \textless2 mmol/L). The primary endpoint was mortality on day 28 after randomisation in the intention-to-treat-population. This study is registered with ClinicalTrials.gov, number NCT01802099. FINDINGS: After the second interim analysis, the independent Data Safety and Monitoring Board deemed that completing patient enrolment was unlikely to significantly change the results of the trial and recommended stopping patient recruitment. Between March 22, 2013, and June 30, 2015, 2410 patients were enrolled and randomly assigned; 1202 to the enteral group and 1208 to the parenteral group. By day 28, 443 (37%) of 1202 patients in the enteral group and 422 (35%) of 1208 patients in the parenteral group had died (absolute difference estimate 2.0%; [95% CI -1.9 to 5.8]; p=0.33). Cumulative incidence of patients with ICU-acquired infections did not differ between the enteral group (173 [14%]) and the parenteral group (194 [16%]; hazard ratio [HR] 0.89 [95% CI 0.72-1.09]; p=0.25). Compared with the parenteral group, the enteral group had higher cumulative incidences of patients with vomiting (406 [34%] vs 246 [20%]; HR 1.89 [1.62-2.20]; p\textless0.0001), diarrhoea (432 [36%] vs 393 [33%]; 1.20 [1.05-1.37]; p=0.009), bowel ischaemia (19 [2%] vs five [\textless1%]; 3.84 [1.43-10.3]; p=0.007), and acute colonic pseudo-obstruction (11 [1%] vs three [\textless1%]; 3.7 [1.03-13.2; p=0.04). INTERPRETATION: In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocaloric parenteral nutrition. FUNDING: La Roche-sur-Yon Departmental Hospital and French Ministry of Health.
- Published
- 2018
53. Interleukine-22 et cellules épithéliales alvéolaires : impact sur la réponse immune innée dans un modèle de pneumonie à Pseudomonas aeruginosa
- Author
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Lamberet, R., primary, Broquet, A., additional, Boutoille, D., additional, Asehnoune, K., additional, and Caillon, J., additional
- Published
- 2019
- Full Text
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54. 0.5% levobupivacaine versus 0.5% ropivacaine: Are they different in ultrasound-guided sciatic block?
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Pham Dang C, Langlois C, Lejus C, Nguyen Jm, Lambert C, and Asehnoune K
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ropivacaine ,medicine.medical_specialty ,business.industry ,Ropivacaine ,ultrasound ,Ultrasound ,Block (permutation group theory) ,Context (language use) ,Surgery ,lcsh:RD78.3-87.3 ,Saphenous nerve ,Anesthesiology and Pain Medicine ,Quartile ,Levobupivacaine ,lcsh:Anesthesiology ,Anesthesia ,Medicine ,Original Article ,Sciatic nerve ,Erratum ,business ,sciatic ,medicine.drug - Abstract
Context and Aims: Little is known about onset and duration of sciatic block after 0.5% levobupivacaine (Levo) versus 0.5% ropivacaine (Ropi) for ultrasound-guided technique. We assessed these parameters in the ultrasound-guided block, to know for the practice. Setting and Design: A comparative randomized double-blind study was conducted in the University Hospital. Materials and Methods: Were included 35 adults of ASA I-II, scheduled for foot surgery, presenting clear imaging of their sciatic nerve at mid-thigh. A volume of 20 mL of either 0.5% Levo or 0.5% Ropi were injected around the sciatic nerve at mid-thigh using ultrasound guidance (out of the plane) followed by placement of a catheter to use, if necessary, for perioperative analgesia. A femoral single shot block was systematically performed to block the saphenous nerve. The onset times until complete foot block (primary outcome) and the sensory and motor block duration (secondary outcome) were assessed using Wilcoxon test. Values were expressed as medians (1 st -3 rd quartile). Results: Except for two delayed sciatic blocks in each group, the onset time otherwise was 35 min (20-60) in Ropi versus 40 min (30-60) in Levo, P = 0.5. Sensory block lasted longer in Levo, 17 h (14-27) compared with 15 h (10-17) in Ropi, P = 0.04. No significant between-group difference was found with motor block durations, 15 h (12-18) in Levo and 15 h (12-16) in Ropi, P = 0.3. Conclusion: No difference of onset times was found in ultrasound-guided sciatic block whether using Levo or Ropi. Levo induced a longer-lasting sensory block.
- Published
- 2015
55. Intracerebral hemorrhage in ICU: is it worth treating?
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Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, Kingma, W, Navis, G, Boerma, E, Rulisek, J, Balik, M, Zacharov, S, Kim, H, Jeon, S, Namgung, H, Lee, E, Cho, Y, Lee, Y, Huang, A, Cioccari, L, Luethi, N, Mårtensson, J, Bellomo, R, Forsberg, M, Edman, G, Höjer, J, Forsberg, S, Freile, M, Hidalgo, F, Molina, J, Lecumberri, R, Rosselló, A, Travieso, P, Leon, G, Sanchez, J, Frias, L, Rosello, D, Verdejo, J, Serrano, J, Winterwerp, D, van Galen, T, Vazin, A, Karimzade, I, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, B, Kureshi, N, Fenerty, L, Thibault Halman, G, Erdogan, M, Walling, S, Green, R, Clarke, D, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Politi, E, Kostopanagiotou, G, Crewdson, K, Rehn, M, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Baker, C, Mansfield, L, Stafford, V, Wade, C, Watson, G, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Furneval, J, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Baudouin, S, Ramírez, C, Escalada, S, Viera, M, Santana, M, Balcázar, L, Monroy, N, Campelo, F, Vázquez, C, Santana, P, Santana, S, Quintard, H, Bouzat, P, Wollersheim, T, Malleike, J, Haas, K, Carbon, N, Schneider, J, Birchmeier, C, Fielitz, J, Spuler, S, Weber Carstens, S, Enseñat, L, Pérez Madrigal, A, Saludes, P, Proença, L, Gruartmoner, G, Espinal, C, Mesquida, J, Huber, W, Eckmann, M, Elkmann, F, Gruber, A, Lahmer, T, Mayr, U, Herner, A, Schellnegger, R, Schmid, R, Ayoub, W, Samy, W, Esmat, A, Battah, A, Mukhtar, S, Mongkolpun, W, Cortés, D, Cordeiro, C, Funcke, S, Groesdonk, H, Saugel, B, Wagenpfeil, G, Wagenpfeil, S, Reuter, D, Fernandez, M, Fernandez, R, Magret, M, González Castro, A, Bouza, M, García, C, Balerdi, B, Mas, A, Arauzo, V, Añón, J, Ruiz, F, Ferreres, J, Tomás, R, Alabert, M, Tizón, A, Altaba, S, Llamas, N, Goligher, E, Fan, E, Herridge, M, Vorona, S, Sklar, M, Dres, M, Rittayamai, N, Lanys, A, Urrea, C, Tomlinson, G, Reid, W, Rubenfeld, G, Kavanagh, B, Brochard, L, Ferguson, N, Neto, A, de Abreu, M, Pelosi, P, Schultz, M, Guérin, C, Papazian, L, Reignier, J, Ayzac, L, Loundou, A, Forel, J, Rolland Debord, C, Bureau, C, Poitou, T, Clavel, M, Perbet, S, Terzi, N, Kouatchet, A, Similowski, T, Demoule, A, Hunfeld, N, Trogrlic, Z, Ladage, S, Osse, R, Koch, B, Rietdijk, W, Devlin, J, van der Jagt, M, Picetti, E, Ceccarelli, P, Mensi, F, Malchiodi, L, Risolo, S, Rossi, I, Antonini, M, Servadei, F, Caspani, M, Roquilly, A, Lasocki, S, Seguin, P, Geeraerts, T, Perrigault, P, Dahyot Fizelier, C, Paugam Burtz, C, Cook, F, Cinotti, R, Dit Latte, D, Mahe, P, Fortuit, C, Feuillet, F, Asehnoune, K, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Barbadillo, S, de Molina, F, Álvarez Lerma, F, Rodríguez, A, Zakharkina, T, Martin Loeches, I, Matamoros, S, Povoa, P, Torres, A, Kastelijn, J, Hofstra, J, de Jong, M, Sterk, P, Artigas, A, Bos, L, Moreau, A, Salluh, J, Rodriguez, A, Nseir, S, de Jong, E, van Oers, J, Nijsten, M, de Lange, D, Bonvicini, D, Labate, D, Benacchio, L, Olivieri, A, Pizzirani, E, Lopez Delgado, J, Gonzalez Romero, M, Fuentes Mila, V, Berbel Franco, D, Romera Peregrina, I, Martinez Pascual, A, Perez Sanchez, J, Abellan Lencina, R, Ávila Espinoza, R, Moreno Gonzalez, G, Sbraga, F, Griffiths, S, Grocott, M, Doyle, J, Wilkerson, P, Soon, Y, Huddart, S, Dickinson, M, Riga, A, Zuleika, A, Miyamoto, K, Kawazoe, Y, Morimoto, T, Yamamoto, T, Fuke, A, Hashimoto, A, Koami, H, Beppu, S, Katayama, Y, Ito, M, Ohta, Y, Yamamura, H, Rygård, S, Holst, L, Wetterslev, J, Johansson, P, Perner, A, Soliman, I, van Dijk, D, van Delden, J, Cremer, O, Mcwilliams, D, Snelson, C, Neves, A, Loudet, C, Busico, M, Vazquez, D, Villalba, D, Veronesi, M, Lischinsky, A, López, F, Mori, L, Plotnikow, G, Díaz, A, Giannasi, S, Hernandez, R, Krzisnik, L, Cecotti, C, Viola, L, Lopez, R, Sottile, J, Benavent, G, Estenssoro, E, Chen, C, Lai, C, Cheng, K, Chou, W, Chan, K, Roeker, L, Horkan, C, Gibbons, F, Christopher, K, Weijs, P, Mogensen, K, Rawn, J, Robinson, M, Tang, Z, Qiu, C, Ouyang, B, Cai, C, Guan, X, Regueira, T, Cea, L, Carlos, S, Elisa, B, Puebla, C, Vargas, A, Poulsen, M, Thomsen, L, Kjærgaard, S, Rees, S, Karbing, D, Frank, S, Müller, M, Skrypnikov, V, Pickerodt, P, Falk, R, Mahlau, A, Lee, A, Inglis, R, Morgan, R, Barker, G, Kamata, K, Abe, T, Saitoh, D, Tokuda, Y, Butler, M, Hwa, H, Gil, L, Vaquero, R, Rodriguez Ruiz, E, Lago, A, Allut, J, Gestal, A, Thomas Rüddel, D, Schwarzkopf, D, Fleischmann, C, Reinhart, K, Suwanpasu, S, Sattayasomboon, Y, Filho, N, Oliveira, J, Ballalai, C, De Lucia, C, Araponga, G, Veiga, L, Silva, C, Garrido, M, Ramos, B, Ricaldi, E, Gomes, S, Wright, C, Docking, R, Doherty, P, Black, E, Stenhouse, P, Plummer, M, Finnis, M, Phillips, L, Kar, P, Bihari, S, Biradar, V, Moodie, S, Horowitz, M, Shaw, J, Yatabe, T, Inoue, S, Sakaguchi, M, Egi, M, Abdelhamid, Y, Hokka, M, Mizobuchi, S, Giersch, E, Summers, M, Hatzinikolas, S, Heller, S, Jones, K, Schweizer, R, Jacquet Lagreze, M, Portran, P, Junot, S, Allaouchiche, B, Fellahi, J, Guerci, P, Ergin, B, Kapucu, A, Ince, C, Crisman, M, Shinotsuka, C, Fagnoul, D, Orbegozo, D, Preiser, J, Thooft, A, Brimioulle, S, Iwasaka, H, Tahara, S, Nagamine, M, Ichigatani, A, Cabrera, A, Zepeda, E, Granillo, J, Sánchez, J, Montoya, A, Montenegro, A, Blanco, G, Robles, C, Drolz, A, Horvatits, T, Roedl, K, Rutter, K, Funk, G, Schneeweiss, B, Fuhrmann, V, Sabetian, G, Pooresmaeel, F, Ghaffaripour, S, Farbod, A, Tabei, H, Taheri, L, Anandanadesan, R, Metaxa, V, Teixeira, C, Pereira, S, Hernández Marrero, P, Carvalho, A, Beckmann, M, Hartog, C, Raadts, A, Robertsen, A, Førde, R, Skaga, N, Helseth, E, Honeybul, S, Ho, K, Lopez, P, Ortega, P, Sola, E, Spasova, T, Kopecky, O, Rusinova, K, Waldauf, P, Cepeplikova, Z, Domínguez, J, Almudevar, P, Carmona, S, Muñoz, J, Castañeda, D, Abellán, A, Villamizar, P, Ramos, J, Pérez, L, Lucendo, A, Ejarque, M, Estella, A, Camps, V, Martín, M, Masnou, N, Barbosa, S, Varela, A, Palma, I, Cristina, L, Nunes, E, Pereira, I, Campello, G, Granja, C, Pande, R, Pandey, M, Varghese, S, Chanu, M, Van Dam, M, Ter Braak, E, Gracia, M, Viciana, R, Recuerda, M, Fontaiña, L, Tharmalingam, B, Kovari, F, Rose, L, Mcginlay, M, Amin, R, Burns, K, Connolly, B, Hart, N, Jouvet, P, Katz, S, Leasa, D, Mawdsley, C, Mcauley, D, Blackwood, B, Denham, S, Worrall, R, Arshad, M, Isherwood, P, Khadjibaev, A, Sabirov, D, Rosstalnaya, A, Parpibaev, F, Sharipova, V, Guzman, C, Cha, Y, Lee, S, Tyagi, N, Rajput, R, Taneja, S, Singh, V, Sharma, S, Mittal, S, Rao, B, Ayachi, J, Fraj, N, Romdhani, S, Khedher, A, Meddeb, K, Sma, N, Azouzi, A, Bouneb, R, Chouchene, I, El Ghardallou, M, Boussarsar, M, Jennings, R, Walter, E, Ribeiro, J, Moniz, I, Marçal, R, Santos, A, Candeias, C, E. 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- Subjects
intracerebral haemorrhage in intensive care - Published
- 2016
56. La modulation in situ des fonctions phagocytaires des macrophages alvéolaires (MA) résidents après la résolution d’une infection primaire induit une sensibilité prolongée à une infection secondaire
- Author
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Jacqueline, C., primary, Davieau, M., additional, Broquet, A., additional, Misme, B., additional, Chaumette, T., additional, Vourc’h, M., additional, Cinotti, R., additional, Villadangos, J., additional, Asehnoune, K., additional, and Roquilly, A., additional
- Published
- 2018
- Full Text
- View/download PDF
57. Ischémies digitales : présentation clinique, étiologies et suivi à long terme. Une cohorte de 323 patients
- Author
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Raimbeau, A., primary, Pistorius, M.-A., additional, Goueffic, Y., additional, Connault, J., additional, Plissonneau, P., additional, Maurel, B., additional, Reignier, J., additional, Asehnoune, K., additional, Aartifoni, M., additional, Didier, Q., additional, Gautier, G., additional, Trochu, J.-N., additional, Rozec, B., additional, N’Gohou, C., additional, Durant, C., additional, Pottier, P., additional, Planchon, B., additional, Agard, C., additional, and Espitia, O., additional
- Published
- 2018
- Full Text
- View/download PDF
58. The research agenda for trauma critical care
- Author
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Asehnoune, K, Balogh, Z, Citerio, G, Cap, A, Billiar, T, Stocchetti, N, Cohen, M, Pelosi, P, Curry, N, Gaarder, C, Gruen, R, Holcomb, J, Hunt, B, Juffermans, N, Maegele, M, Midwinter, M, Moore, F, O’Dwyer, M, Pittet, J, Schöchl, H, Schreiber, M, Spinella, P, Stanworth, S, Winfield, R, Brohi, K, Asehnoune, K, Balogh, Z, Citerio, G, Cap, A, Billiar, T, Stocchetti, N, Cohen, M, Pelosi, P, Curry, N, Gaarder, C, Gruen, R, Holcomb, J, Hunt, B, Juffermans, N, Maegele, M, Midwinter, M, Moore, F, O’Dwyer, M, Pittet, J, Schöchl, H, Schreiber, M, Spinella, P, Stanworth, S, Winfield, R, and Brohi, K
- Abstract
In this research agenda on the acute and critical care management of trauma patients, we concentrate on the major factors leading to death, namely haemorrhage and traumatic brain injury (TBI). In haemostasis biology, the results of randomised controlled trials have led to the therapeutic focus moving away from the augmentation of coagulation factors (such as recombinant factor VIIa) and towards fibrinogen supplementation and administration of antifibrinolytics such as tranexamic acid. Novel diagnostic techniques need to be evaluated to determine whether an individualised precision approach is superior to current empirical practice. The timing and efficacy of platelet transfusions remain in question, while new blood products need to be developed and evaluated, including whole blood variants, lyophilised products and novel red cell storage modalities. The current cornerstones of TBI management are intracranial pressure control, maintenance of cerebral perfusion pressure and avoidance of secondary insults (such as hypotension, hypoxaemia, hyperglycaemia and pyrexia). Therapeutic hypothermia and decompressive craniectomy are controversial therapies. Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for predicting the long-term outcome in mild and severe TBI. Novel biomarkers may also help in outcome prediction and may predict chronic neurological symptoms. For trauma in general, rehabilitation is complex and multidimensional, and the optimal timing for commencement of rehabilitation needs investigation. We propose priority areas for clinical trials in the next 10 years
- Published
- 2017
59. ESICM LIVES 2016: part two
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Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Meleti, D. E., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. 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Cambronero, Jiménez, R., Rebollo, S., Alejandro, O., Fernández, A., Moreno, S., Herrera, L., Ojados, A., Galindo, M., Murcia, J., Contreras, M., Sánchez-Argente, S., Bonilla, Y., Rodríguez, M. D., Allegue, J. M., Cakin, Ö., Parlak, H., Kirca, H., Mutlu, F., Aydınlı, B., Cengiz, M., Ramazanoglu, A., Jung, E.-J., Oh, S.-Y., Domenech, J. Cebrián, Montalvo, A. Pinos, Chornet, T. Ciges, Martinez, P. Concha, Ribas, M. Piñol, Costa, R. Gimeno, Ortega, A. Castellanos, Forbes, C., Prescott, H., Lal, A., Khan, F. A., Dela Pena, E. G., Dizon, J. S., Perez, P. P. P., Wong, C. M. J., Garach, M. Muñoz, Romero, O. Moreno, Puerta, R. Ramirez, Diaz, F. Acosta, Bailon, A. M. Perez, Pinel, A. Carranza, Maldonado, L. Peñas, Kalaiselvan, M. S., kumar, R. L. Siva, Renuka, M. K., Kumar, A. S. Arun, De Rosa, S., Ferrari, F., Checcacci, S. Carboni, Rigobello, A., Joannidis, M., Politi, F., Pellizzari, A., Bonato, R., Fernandez-Carmona, A., Macias-Guarasa, I., Gutierrez-Rodriguez, R., Martinez-Lopez, P., Diaz-Castellanos, M. A., Arias-Diaz, M., Aguilar-Alonso, E., Nikandish, R. N., Artemenko, V., Budnyuk, A., Bassi, G. Li, Senussi, T., Idone, F., Xiol, E. Aguilera, Travierso, C., Chiurazzi, C., Motos, A., Amaro, R., Hua, Y., Fernández-Barat, L., Ranzani, O. T., Bobi, Q., Rigol, M., Youn, A., Hwang, J. Gyung, Ossorio, M. E. Yuste, Figueira, H., Oliveira, R., Mota, A., Kamp, O., Cruciger, O., Aach, M., Kaczmarek, C., Waydhas, C., Schildhauer, T. A., Hamsen, U., Camprubí-Rimblas, M., Chimenti, L., Guillamat-Prats, R., Lebouvier, T., Bringué, J., Tijero, J., Gómez, M. N., Blanch, L., Tagliabue, G., Ji, M., Jagers, J. V. Suneby, Easton, P. A., Martins, A. M. C. R. P. F., Hong, J. Y., Shin, M. H., Park, M. S., Pomprapa, A., Hofferberth, M. B. T., Russ, M., Braun, W., Walter, M., Francis, R., Lachmann, B., Leonhardt, S., Landaverde-López, A., Canedo-Castillo, N. A., Esquivel-Chávez, A., Arvizu-Tachiquín, P. C., Baltazar-Torres, J. A., Cardoso, V., Krystopchuk, A., Castro, S., Melão, L., Firmino, S., Marreiros, A., Almaziad, S., Kubbara, A., Barnett, W., Nakity, R., Alamoudi, W., Altook, R., Tarazi, T., Fida, M., Safi, F., Assaly, R., Santini, A., Milesi, M., Maraffi, T., Pugni, P., Cavenago, M., Gattinoni, L., Protti, A., Perchiazzi, G., Borges, J. B., Bayat, S., Porra, L., Broche, L., Hedenstierna, G., Larsson, A., Roneus, A., Segelsjö, M., Vestito, M. C., Gremo, E., Nyberg, A., Castegren, M., Pikwer, A., Yoshida, T., Engelberts, D., Otulakowski, G., Katira, B., Post, M., Brochard, L., Amato, M. B. P., Koch, N., Hoellthaler, J., Mair, S., Phillip, V., Beitz, A., Baladrón, V., Villarejo, P., Steenstra, R. J., Banierink, H., Hof, J., van der Horst, I. C., Nijsten, M. W., Hoekstra, M., Sterz, F., Horvatits, K., Herkner, H., Kott, M., Zitta, K., Brandt, B., Schildhauer, C., Elke, G., Hummitzsch, L., Albrecht, M., González, L. Rey, Alonso, D. Cabestrero, Sánchez, R. de Pablo, Lucas, J. Higuera, Ferlitsch, A., Fauler, G., Trauner, M., Pischke, S., Fischer, L., Thaiss, F., Koch, M., Bangert, K., Lohse, A. W., Nashan, B., Sterneck, M., Faenza, S., Siniscalchi, A., Pierucci, E., Mancini, E., Ricci, D., Gemelli, C., Cuoghi, A., Magnani, S., Atti, M., Sotos, F., Cánovas, J., López, A., Burruezo, A., Torres, D., Herrera-Gutierrez, M. E., Barrueco-Francioni, J., Arias-Verdú, D., Lozano-Saez, R., Quesada-Garcia, G., Seller-Pérez, G., Figueiredo, A., Anzola, Y., Pereira, R., Bento, L., Lai, M., Deiana, M., Seller-Perez, G., Vardas, K., Ilia, S., Sertedaki, A., Charmadari, E., Stratakis, C. A., Briassouli, E., Goukos, D., Psarra, K., Botoula, E., Tsagarakis, S., Mageira, E., Routsi, C., Nanas, S., Campello, E., Radu, C. M., Su, H., Lam, Y. M., Willis, K., Pullar, V., Hubner, R. P., Tsang, J. L., de Guadiana-Romualdo, L. García, Rebollo-Acebes, S., Esteban-Torrella, P., Jiménez-Sánchez, R., Jiménez-Santos, E., Ortín-Freire, A., Hernando-Holgado, A., Albaladejo-Otón, M. D., Coelho, L., Rabello, L., Póvoa, P., Varis, E., Poukkanen, M., Jacob, S., Takala, J., Wilkman, E., Lundberg, O. H. M., Bergenzaun, L., Rydén, J., Rosenqvist, M., Melander, O., Chew, M. S., Kishihara, Y., Yasuda, H., Jimenez, R., Torrella, P. Esteban, Fernandez, A., Sanchez, S., Ortin, A., Prats, R. Guillamat, Aguilera, E., Marti, D., Fernandez, L., Ferrer, M., Lanziotti, V. S., Pulcheri, L., Ribeiro, M. O., Barbosa, A. P., e Silva, J. R. Lapa, Soares, M., Salluh, J. I. F., Marqués, M. Gil, Moreno, A. Puppo, Pizarraya, A. Gutierrez, Diaz, J. Pachón, Smani, Y., Connell, M. Mc, Zhang, L. A., Parker, R. S., Banerjee, I., Clermont, G., Norberg, E., Oras, J., Cuisinier, A., Maufrais, C., Payen, J. F., Nottin, S., Walther, G., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Monfort, B., Stazi, E., Roig, A. Lozano, Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Arunkumar, A. S., Lozano, A., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. Vieira, Amarante, G., Skorko, A., Sanders, S., Aron, J., Kroll, R. J., Redfearn, C., Krishnan, P., Khalil, J. E., Kongpolprom, N., Gulia, V., Lourenço, E., Duro, C., Baptista, G., Alves, A., Arminda, B., Rodrigues, M., Hayward, J., Baldwin, F., Gray, R., Katinakis, P. A., Stijf, M., Ten Kleij, M., Jansen-Frederiks, M., Broek, R., de Bruijne, M., Spronk, P. E., Sinha, K., Luney, M., Palmer, K., Keating, L., Abu-Habsa, M., Bahl, R., Baskaralingam, N., Ahmad, A., Kanapeckaite, L., Bhatti, P., Glace, S., Jeyabraba, S., Lewis, H. F., Kostopoulos, A., Raja, M., West, A., Ely, A., Turkoglu, L. M., Zolfaghari, P., Baptista, J. P., Marques, M. P., Martins, P., Pimentel, J., Su, Y. C., Villacres, S., Stone, M. E., Parsikia, A., Medar, S., O’Dea, K. P., Porter, J., Tirlapur, N., Jonathan, J. M., Singh, S., Takata, M., McWhirter, E., Lyon, R., Hariz, M. L., Azmi, E., Alkhan, J., Movsisyan, V., Petrikov, S., Marutyan, Z., Aliev, I., Evdokimov, A., Antonucci, E., Merz, T., Hartmann, C., Calzia, E., Radermacher, P., Nußbaum, B., Huber-Lang, M., Gröger, M., Svoren-Jabalera, E., Davenport, E. E., Humburg, P., Knight, J., Hinds, C. J., Jun, I. J., Kim, W. J., Lee, E. H., Besch, G., Perrotti, A., Puyraveau, M., Baltres, M., Samain, E., Chocron, S., Pili-Floury, S., Plata-Menchaca, E. P., Sabater-Riera, J., Estruch, M., Boza, E., Toscana-Fernández, J., Bruguera-Pellicer, E., Ordoñez-Llanos, J., Pérez-Fernández, X. L., Cavaleiro, P., Tralhão, A., Arrigo, M., Lopes, J.-P., Lebrun, M., Cholley, B., PerezVela, J. L., MarinMateos, H., Rivera, J. J. Jimenez, Llorente, M. A. Alcala, De Marcos, B. Gonzalez, Fernandez, F. J. Gonzalez, Laborda, C. Garcia, Zamora, D. Fernandez, Delgado, J. C. Lopez, Imperiali, C., Dastis, M., Górka, J., Górka, K., Iwaniec, T., Frołow, M., Polok, K., Fronczek, J., Kózka, M., Musiał, J., Szczeklik, W., Sileli, M., Moursia, C., Maleoglou, H., Leleki, K., Uz, Z., Ince, Y., Papatella, R., Bulent, E., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Tamura, T., Miyajima, I., Yamashita, K., Yokoyama, M., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Hathorn, K. E., Purtle, S. W., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Lorente, M., Włudarczyk, A., Hałek, A., Bargouth, M., Bennasr, M., Abdelghani, K. Ben, Abdallah, T. Ben, Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Welsh, S. P., Guerra, E., Zerpa, M. C. l., Zechner, F., Berdaguer, F., Risso-Vazquez, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Morales, M. A. Lopez, Pires, T., and Azevedo, L. C. P.
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Meeting Abstracts - Abstract
Introduction In addition to systemic hemodynamics, the management\ud of neurocritically ill patients is often informed by neuromonitoring. In\ud the absence of high-level evidence clinicians are often guided by personal\ud and local expertise. Little is known about practices as they pertain\ud to the use of such monitoring in patients with acute brain injury (ABI).\ud Objectives To investigate practices in bedside monitoring for ABI patients.\ud Particularly interested in differences among “neurointensivists”\ud (NIs; defined here as intensivists whose clinical practice is comprised\ud > 1/3 by neurocritical care) and other intensivists (OIs). Also, to\ud explore patterns specific to traumatic brain injury (TBI) and subarachnoid\ud hemorrhage (SAH), as well as preferences and availability of\ud particular technologies/devices.\ud Methods Electronic survey of 22 items including two case-based scenarios;\ud endorsed by SCCM (9,000 recipients) and ESICM (on-line\ud newsletter) in 2013. A sample size of 370 was calculated based on a\ud population of 10,000 physician members, a 5 % margin error, and\ud 95 % confidence interval. We summarized results using descriptive\ud statistics (proportions with 95 % confidence intervals). A chi-square\ud test was used to compare proportions of responses between NIs and\ud OIs with a significance p < 0.05.\ud Results There were 655 responders (66 % completion rate); 422(65 %)\ud were classified as OIs and 226(35 %) as NIs. More NIs follow\ud hemodynamic protocols for neurocritically-ill patients (56 % vs. 43 %, p\ud 0.001), in TBI (44.5 % vs. 33.3 %, p 0.007), and in SAH (38.1 % vs. 21.3 %,\ud p < 000.1). For delayed cerebral ischemia (DCI), more NIs target cardiac\ud index (CI) (35 % vs. 21 %, p 0.0001), and fluid responsiveness (62 % vs.\ud 53 %, p 0.03), use more bedside ultrasound (BUS) (42 % vs. 29 %, p\ud 0.005) and arterial waveform analysis (40 % vs. 29 %, p 0.02). For DCI\ud neuromonitoring, NIs use more angiography (57 % vs. 43 %, p 0.004),\ud TCD (46 % vs. 38 %, p 0.0001), and CTP (32 % vs.16 %, p 0.0001). For\ud CPP optimization in TBI, NIs use more arterial waveform analysis (45 %\ud vs. 35 %, p 0.019), and BUS (37 % vs. 27.7 %, p 0.023), while more OIs\ud monitor mixed venous oxygen saturation (54.1 % vs. 45 %, p 0.045). For\ud TBI neuromonitoring, NIs use more PbtO2 (28 % vs. 10 %, p 0.0001). In\ud the case scenario of raised ICP/low PbtO2, most employ analgosedation\ud (47 %) and osmotherapy (38 %). Fewer make use of preserved pressure\ud reactivity, particularly OIs (vasopressor use 23 % vs. 34 %, p 0.014).\ud Conclusions There is large heterogeneity in the use of monitoring protocols,\ud variables, and technologies/devices. “Neurointensivists” not only\ud employ more neuromonitoring but also more hemodynamic monitoring\ud in patients with acute brain injury. ICP/CPP remain the most commonly\ud followed neuro-variables in TBI patients, with low use of other\ud brain-physiology parameters, sugg
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- 2016
60. White coats: How long should doctors wear them?
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Gouraud, D., Dumont, R., Asehnoune, K., and Lejus, C.
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- 2014
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61. Le ventilator-free days comme critère de jugement dans les études de recherche clinique en réanimation : proposition d’une approche multi-état alternative
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Frasca, D., primary, Feuillet, F., additional, Contentin, L., additional, Asehnoune, K., additional, Roquilly, A., additional, Mimoz, O., additional, Giraudeau, B., additional, and Foucher, Y., additional
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- 2016
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62. Reply to Hurley
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Roquilly, A., primary, Marret, E., additional, Abraham, E., additional, and Asehnoune, K., additional
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- 2015
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63. Hypotension during surgery for femoral neck fracture in elderly patients: effect of anaesthetic techniques. A retrospective study
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Vincent Minville, Asehnoune K, Delussy A, Fourcade O, Colombani A, Rabinowitz A, and Samii K
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Aged, 80 and over ,Male ,Incidence ,Humans ,Female ,Anesthesia, General ,Anesthetics, Local ,Hypotension ,Anesthesia, Spinal ,Bupivacaine ,Aged ,Femoral Neck Fractures ,Retrospective Studies - Abstract
The aim of this retrospective study was to compare the incidence of hypotension between different anaesthetic techniques, including general anaesthesia (GA), spinal anaesthesia single injection (SA), continuous spinal anaesthesia with 2.5 mg bolus injections as needed (CSA 2.5) or 5 mg bolus injections as needed (CSA 5) in elderly patients (75 yrs old) undergoing surgery for femoral neck fractures.Demographic, surgical and hemodynamic data from 333 patients over a four year period within a single hospital were recorded and examined.Forty-two patients underwent GA, 109 underwent SA, 61 underwent CSA 5, and 121 underwent CSA 2.5. Patients receiving GA, SA or CSA 5 had a higher incidence of hypotension (83%, 68%, and 34%, respectively) than patients who underwent CSA 2.5 (4%; P0.05). The CSA 2.5 group required less colloid infusion (490+/-50 mL) than the GA and SA groups (810+/-330 and 645+/-230 mL, respectively). The CSA 2.5 group also required less crystalloid infusion volume (760+/-371 mL) than the GA group (1140+/-770 mL). Ephedrine infusion was higher in the GA and SA groups (30+/-10 and 26+/-9 mg, respectively) than the CSA 2.5 (15+/-8 mg; P0.05).This study demonstrated that CSA 2.5 causes fewer episodes of hypotension than other anaesthetic techniques for surgical repair of hip fracture in elderly patients.
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- 2008
64. Impact du linézolide (LZD) et de la vancomycine (VAN) sur la production de cytokines et sur la réponse inflammatoire de l’hôte dans un modèle murin de pneumonie à Staphylococcus aureus résistant à la méticilline (SARM)
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Jacqueline, C., primary, Broquet, A., additional, Roquilly, A., additional, Vourc’h, M., additional, Potel, G., additional, Caillon, J., additional, and Asehnoune, K., additional
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- 2014
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65. Thromboprophylaxie en chirurgie bariatrique : quelle stratégie optimale
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Degirmenci, S.E., primary, Junke, E., additional, Péricard, C., additional, Figier, M., additional, Asehnoune, K., additional, Rohr, S., additional, Vix, M., additional, Grunebaum, L., additional, Toti, F., additional, Mertes, P.M., additional, and Steib, A., additional
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- 2014
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66. Impact du contrôle glycémique strict assisté par ordinateur sur la récupération neurologique des patients cérébro-lésés graves de réanimation. Etude ancillaire multi-centrique de l’étude CGAO-REA
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Cinotti, R., primary, Ichai, C., additional, Orban, J.-C., additional, Kalfon, P., additional, Feuillet, F., additional, Roquilly, A., additional, Riou, B., additional, Blanloeil, Y., additional, Asehnoune, K., additional, and Rozec, B., additional
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- 2014
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67. Étude des relations entre le système sympathique et l’immunité innée. Mise en place d’un modèle d’immunosuppression par lésion médullaire
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Ambrosi, X., primary, Broquet, A., additional, Ruggeri, T., additional, Jacqueline, C., additional, Caillon, J., additional, and Asehnoune, K., additional
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- 2014
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68. Immunosubversion du lymphocyte Natural Killer (NK) par Pseudomonas aeruginosa
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Vourc’h, M., primary, Retière, C., additional, David, G., additional, Roquilly, A., additional, Broquet, A., additional, Jacqueline, C., additional, and Asehnoune, K., additional
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- 2014
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69. Antibioprophylaxie par céfazoline : concentrations tissulaires après une sleeve gastrectomie chez les patients obèses. Résultats préliminaires
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Ronchi, L., primary, Dumont, R., additional, Roquilly, A., additional, Dailly, E., additional, Letessier, E., additional, Lejus, C., additional, and Asehnoune, K., additional
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- 2014
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70. Quels sont les facteurs d’échec de l’électroconvulsivothérapie ?
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Malidin, A., primary, Roquilly, A., additional, Vanelle, J.-M., additional, Asehnoune, K., additional, and Lejus, C., additional
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- 2014
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71. Bactéries résistantes chez les patients cérébrolésés présentant une pneumonie acquise sous ventilation mécanique : développement et validation d’un score prédictif dans une cohorte prospective multicentrique
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Roquilly, A., primary, Feuillet, F., additional, Launey, Y., additional, Thioliere, L., additional, Cinotti, R., additional, Nesseler, N., additional, Rozec, B., additional, Seguin, P., additional, Lasocki, S., additional, Sébille, V., additional, and Asehnoune, K., additional
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- 2014
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72. CNAP™ (continuous non invasive arterial pressure) : fiabilité en réanimation
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Martin, M., primary, Faiz, S., additional, Boulain, T., additional, Ehrmann, S., additional, Capdevila, X., additional, Asehnoune, K., additional, Blanlœil, Y., additional, Rozec, B., additional, and Lakhal, K., additional
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- 2014
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73. Linezolid Dampens Neutrophil-Mediated Inflammation in Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia and Protects the Lung of Associated Damages
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Jacqueline, C., primary, Broquet, A., additional, Roquilly, A., additional, Davieau, M., additional, Caillon, J., additional, Altare, F., additional, Potel, G., additional, and Asehnoune, K., additional
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- 2014
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74. Traitement de l’hypertension intracrânienne post-traumatique : quel impact sur le devenir des patients ?
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Roquilly, A., primary and Asehnoune, K., additional
- Published
- 2014
- Full Text
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75. Effets immunologiques de l’hydrocortisone après un traumatisme grave
- Author
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Roquilly A and Asehnoune K
- Subjects
Anesthesiology and Pain Medicine ,Text mining ,business.industry ,Medicine ,General Medicine ,business ,Bioinformatics ,Hydrocortisone ,medicine.drug - Published
- 2012
76. Risk factors and pathogens involved in early ventilator-acquired pneumonia in patients with severe subarachnoid hemorrhage
- Author
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Cinotti, R., primary, Dordonnat-Moynard, A., additional, Feuillet, F., additional, Roquilly, A., additional, Rondeau, N., additional, Lepelletier, D., additional, Caillon, J., additional, Asseray, N., additional, Blanloeil, Y., additional, Rozec, B., additional, and Asehnoune, K., additional
- Published
- 2013
- Full Text
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77. Club 35 Poster session Friday 13 December: 13/12/2013, 08:30-18:00 * Location: Poster area
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Ben Abda, A., primary, Hachulla, E., additional, Polge, A., additional, Richardson, M., additional, Duva Penthia, A., additional, De Groote, P., additional, Montaigne, D., additional, Lamblin, N., additional, Lamer, M., additional, Cinotti, R., additional, Delater, A., additional, Asehnoune, K., additional, Blanloeil, Y., additional, Le Tourneau, T., additional, Rozec, B., additional, Piriou, N., additional, Moon, J., additional, Kim, T., additional, Ahn, T., additional, Chung, W., additional, Chimura, M., additional, Oonishi, T., additional, Tukishiro, Y., additional, Yamada, S., additional, Taniguchi, Y., additional, Yasaka, Y., additional, Kawai, T., additional, Elmissiri, A., additional, Andres Lahuerta, A., additional, Alonso Fernandez, P., additional, Igual Munoz, B., additional, Osca Asensi, J., additional, Cano Perez, O., additional, Jimenez Carreno, R., additional, Sancho-Tello De Carranza, M., additional, Olague De Ros, J., additional, Salvador Sanz, A., additional, Atas, H., additional, Samadov, F., additional, Kepez, A., additional, Sunbul, M., additional, Cincin, A., additional, Direskeneli, H., additional, Tigen, K., additional, Yildiz, A., additional, Karakas, M., additional, Cimen, T., additional, Tuncez, A., additional, Korkmaz, A., additional, Uygur, B., additional, Isleyen, A., additional, Tufekcioglu, O., additional, Melao, F., additional, Paiva, M., additional, Goncalves, A., additional, Pinho, T., additional, Madureira, A., additional, Martins, E., additional, Macedo, F., additional, Maciel, M., additional, Guvenc, T., additional, Erer, H., additional, Kul, S., additional, Oz, D., additional, Koroglu, B., additional, Kaya, Y., additional, Koc, S., additional, Sayar, N., additional, Degirmencioglu, A., additional, Eren, M., additional, Stapor, M., additional, Condemi, F., additional, Bapat, V., additional, Gianstefani, S., additional, Catibog, N., additional, Monaghan, M. J., additional, Carro, A., additional, Pijuan, A., additional, Dos, L., additional, Huguet, F., additional, Abad, C., additional, Gonzalez, N., additional, Miranda, B., additional, Galian, L., additional, Casaldaliga, J., additional, Evangelista, A., additional, Gurzun, M. M., additional, Ionescu, A., additional, Kahraman, E., additional, Sen, T., additional, Guven, S., additional, Keskin, G., additional, Topaloglu, S., additional, Korkmaz, S., additional, Moatemri, F., additional, Mahdhaoui, A., additional, Bouraoui, H., additional, Jeridi, G., additional, Ernez, S., additional, Basaran, O., additional, Gozubuyuk, G., additional, Dundar, C., additional, Tasar, O., additional, Bulut, M., additional, Karaahmet, T., additional, Pala, S., additional, Izgi, A., additional, Kirma, C., additional, Baronaite-Dudoniene, K., additional, Urbaite, L., additional, Smalinskas, V., additional, Veisaite, R., additional, Vasylius, T., additional, Vaskelyte, J., additional, Puodziukynas, A., additional, Teixido-Tura, G., additional, Rodriguez-Palomares, J., additional, Cuellar, H., additional, Pineda, V., additional, Gruosso, D., additional, Gutierrez, L., additional, Moral, S., additional, Gonzalez-Alujas, M., additional, Oprescu, N., additional, Micheu, M., additional, Calmac, L., additional, Pitic, D., additional, Dorobantu, M., additional, Brugger, N., additional, Huerzeler, M., additional, Wustmann, K., additional, Wahl, A., additional, Steck, H., additional, Seiler, C., additional, Ismail, H., additional, Linde, J., additional, Kofoed, K., additional, Dixen, U., additional, Soergaard, M., additional, Hove, J., additional, Willis, J., additional, Oxborough, D., additional, Augustine, D., additional, Knight, D., additional, Coghlan, G., additional, Shah, R., additional, Easaw, J., additional, Verseckaite, R., additional, Pilkauskaite, G., additional, Lapinskas, T., additional, Miliauskas, S., additional, Sakalauskas, R., additional, Jurkevicius, R., additional, Ozeke, O., additional, Turak, O., additional, Ozcan, F., additional, Cay, S., additional, Aras, D., additional, Golbasi, Z., additional, and Aydogdu, S., additional
- Published
- 2013
- Full Text
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78. Organisation de la ventilation artificielle dans les unités de réanimation en France
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Montravers, P., primary, Ichai, C., additional, Dupont, H., additional, Payen, J.F., additional, Orliaguet, G., additional, Blanchet, P., additional, Malledant, Y., additional, Albanèse, J., additional, Asehnoune, K., additional, Bastien, O., additional, Collange, O., additional, Duranteau, J., additional, Garrigues, B., additional, Lepape, A., additional, and Paugam-Burtz, C., additional
- Published
- 2013
- Full Text
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79. La carence martiale (CM) est fréquente après un séjour en réanimation et associée à la fatigue. Étude PRECAR
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Le Moal, C., primary, Papet, T., additional, Roquilly, A., additional, Hamel, J.-F., additional, Chudeau, N., additional, Mimoz, O., additional, Asehnoune, K., additional, Seguin, P., additional, Malledant, Y., additional, and Lasocki, S., additional
- Published
- 2013
- Full Text
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80. Accompagnement à la prescription des examens complémentaires en réanimation : impact sur l’incidence des prescriptions et les coûts
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Le Maguet, P., primary, Tanguy, M., additional, Pilon, C., additional, Asehnoune, K., additional, Mimoz, O., additional, Lasocki, S., additional, Gaillard, T., additional, Morcet, J., additional, Seguin, P., additional, and Mallédant, Y., additional
- Published
- 2013
- Full Text
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81. Étude de la fonction ventriculaire gauche au cours des hémorragies sous-arachnoïdiennes graves par la méthode du Speckle-Tracking. Résultats intermédiaires de l’étude SPLASH
- Author
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Cinotti, R., primary, Piriou, N., additional, Lamer, M., additional, Delater, A., additional, Brisard, L., additional, Lakhal, K., additional, Roquilly, A., additional, Asehnoune, K., additional, Blanloeil, Y., additional, and Rozec, B., additional
- Published
- 2013
- Full Text
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82. La mesure de la pression artérielle (PA) au brassard automatique est-elle moins fiable lors de l’arythmie ?
- Author
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Martin, M., primary, Faiz, S., additional, Reminiac, F., additional, Ehrmann, S., additional, Crouzet, A.-S., additional, Cinotti, R., additional, Capdevilla, X., additional, Asehnoune, K., additional, Blanloeil, Y., additional, Rozec, B., additional, Boulain, T., additional, and Lakhal, K., additional
- Published
- 2013
- Full Text
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83. L’hydrocortisone prévient la destruction des cellules dendritiques par les lymphocytes natural killer au cours de l’immunodépression post-traumatique
- Author
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Roquilly, A., primary, Vourc’h, M., additional, Broquet, A., additional, Jacqueline, C., additional, Caillon, J., additional, and Asehnoune, K., additional
- Published
- 2013
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84. Contrôle glycémique en réanimation : l’histoire sans fin
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Cook, F., primary and Asehnoune, K., additional
- Published
- 2013
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85. Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response
- Author
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Jacqueline, C., primary, Roquilly, A., additional, Desessard, C., additional, Boutoille, D., additional, Broquet, A., additional, Le Mabecque, V., additional, Amador, G., additional, Potel, G., additional, Caillon, J., additional, and Asehnoune, K., additional
- Published
- 2012
- Full Text
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86. Colloïdes ou solutés macromoléculaires de remplissage vasculaire
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Blanlœil, Y., primary, Roquilly, A., additional, Rozec, B., additional, Asehnoune, K., additional, and Lejus, C., additional
- Published
- 2011
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87. Limitation ou arrêt de thérapeutiques actives en situations d’urgence. Le point de vue des anesthésistes réanimateurs
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Dumont, R., primary, Asehnoune, K., additional, Pouplin, L., additional, Volteau, C., additional, Simonneau, F., additional, and Lejus, C., additional
- Published
- 2010
- Full Text
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88. « Boîte labyrinthique » : un outil pédagogique simple et économique d’apprentissage de l’intubation fibroscopique
- Author
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Béliard, C., primary, Péan, D., additional, Asehnoune, K., additional, and Lejus, C., additional
- Published
- 2010
- Full Text
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89. Intubation avec l’Airtraq™ chez un enfant porteur de séquelles graves de brûlure
- Author
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Lejus, C., primary, Pichenot, V., additional, Péan, D., additional, Leboeuf, D., additional, Le Roux, C., additional, and Asehnoune, K., additional
- Published
- 2009
- Full Text
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90. Bilan d’hémostase avant un bloc central chez l’enfant : quelles sont les pratiques françaises ?
- Author
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Pajot, S., primary, Asehnoune, K., additional, Le Roux, C., additional, Léturgie, C., additional, Surbled, M., additional, Bazin, V., additional, and Lejus, C., additional
- Published
- 2009
- Full Text
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91. NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance.
- Author
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Adib-Conquy, M, Adrie, C, Moine, P, Asehnoune, K, Fitting, C, Pinsky, MR, Dhainaut, JF, Cavaillon, JM, Adib-Conquy, M, Adrie, C, Moine, P, Asehnoune, K, Fitting, C, Pinsky, MR, Dhainaut, JF, and Cavaillon, JM
- Abstract
The expression of NF-kappaB was studied in freshly isolated peripheral blood mononuclear cells (PBMC) of patients with severe sepsis and major trauma. The expression of p65p50 heterodimer, the active form of NF-kappaB, was significantly reduced for all patients as compared with control subjects. The p50p50 homodimer, an inhibitory form of NF-kappaB, was reduced in the survivors of sepsis and in patients with trauma. Subsequent in vitro stimulation of PBMC with lipopolysaccharide (LPS) did not induce further NF-kappaB nuclear translocation: the survivors of sepsis and trauma patients showed low expression of both p65p50 and p50p50, whereas nonsurvivors of sepsis showed a predominance of the inactive homodimer and a low p65p50/p50p50 ratio when compared with control subjects. In the later group of patients there was a reverse correlation between plasma IL-10 levels and the p65p50/p50p50 ratio after in vitro LPS stimulation (r = -0.8, p = 0.04). The reduced expression of nuclear NF-kappaB was not due to its inhibition by IkappaBalpha, as very low expression of IkappaBalpha, as well as low levels of p65 and p50 were found in the cytoplasm of PBMC from patients with sepsis and trauma when compared with control subjects. These results demonstrate that upon LPS activation, PBMC of patients with systemic inflammatory response syndrome show patterns of NF-kappaB expression that resemble those reported during LPS tolerance: global down-regulation of NF-kappaB in survivors of sepsis and trauma patients and the presence of large amounts of the inactive homodimer in the nonsurvivors of sepsis.
- Published
- 2000
92. CT recognition of traumatic pneumomyelogram
- Author
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Minville, V., primary, Amathieu, R., additional, Adnet, F., additional, and Asehnoune, K., additional
- Published
- 2006
- Full Text
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93. Fascia-iliaca compartment block for femoral bone fracture in prehospital medicine in a 6-yr-old child
- Author
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Minville, V., primary, Gozlan, C., additional, Asehnoune, K., additional, Zetlaoui, P., additional, Chassery, C., additional, and Benhamou, D., additional
- Published
- 2006
- Full Text
- View/download PDF
94. Prehospital intravenous line placement assessment in the French emergency system
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Minville, V., primary, Pianezza, A., additional, Asehnoune, K., additional, Cabardis, S., additional, and Smail, N., additional
- Published
- 2006
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95. Bloc iliofascial en médecine préhospitalière pour les fractures du fémur
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Gozlan, C., primary, Minville, V., additional, Asehnoune, K., additional, Raynal, P., additional, Zetlaoui, P., additional, and Benhamou, D., additional
- Published
- 2005
- Full Text
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96. Resident Versus Staff Anesthesiologist Performance: Coracoid Approach to Infraclavicular Brachial Plexus Blocks Using a Double-Stimulation Technique
- Author
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MINVILLE, V, primary, ASEHNOUNE, K, additional, CHASSERY, C, additional, NGUYEN, L, additional, GRIS, C, additional, FOURCADE, O, additional, SAMII, K, additional, and BENHAMOU, D, additional
- Published
- 2005
- Full Text
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97. Modulation différentielle des effets de la stimulation des récepteurs Toll-like 2 et 4 par l'état de choc hémorragique
- Author
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Asehnoune, K., primary, Moine, P., additional, Fitting, C., additional, Benhamou, D., additional, Cavaillon, J-M., additional, and Edouard, A., additional
- Published
- 2005
- Full Text
- View/download PDF
98. Fascia-iliaca compartment block for femoral bone fracture in prehospital medicine in a 6-yr-old child
- Author
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Minville, V., primary, Gozlan, C., additional, Asehnoune, K., additional, Zetlaoui, P., additional, Chassery, C., additional, and Benhamou, D., additional
- Published
- 2005
- Full Text
- View/download PDF
99. Information et anesthésie : que souhaite le patient ?
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Asehnoune, K, primary, Albaladejo, P, additional, Smail, N, additional, Heriche, C, additional, Sitbon, P, additional, Gueneron, J.P, additional, Chailloleau, C, additional, and Benhamou, D, additional
- Published
- 2000
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100. Effects of isoflurane on bacterial growth
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Asehnoune, K., primary, Cruaud, P., additional, Paries, J., additional, Gorce, P., additional, and Pourriat, J. -L., additional
- Published
- 2000
- Full Text
- View/download PDF
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