Search

Your search keyword '"Antonazzo P"' showing total 171 results
Start Over Author "Antonazzo P"
171 results on '"Antonazzo P"'

52. GPR Investigation at the Archaeological Site of Le Cesine, Lecce, Italy

Author

Emanuele Colica, Antonella Antonazzo, Rita Auriemma, Luigi Coluccia, Ilaria Catapano, Giovanni Ludeno, Sebastiano D’Amico, and Raffaele Persico

Subjects
ground penetrating radar, archaeology, inverse scattering, shift and zoom, Information technology, T58.5-58.64
Abstract

In this contribution, we present some results achieved in the archaeological site of Le Cesine, close to Lecce, in southern Italy. The investigations have been performed in a site close to the Adriatic Sea, only slightly explored up to now, and where the presence of an ancient Roman harbour is alleged on the basis of remains visible above all under the current sea level. This measurement campaign has been performed in the framework of a short-term scientific mission (STSM) performed in the framework of the European Cost Action 17131 (acronym SAGA), and has been aimed to identify possible points where future localized excavation might and hopefully will be performed in the next few years. Both a traditional elaboration and an innovative data processing based on a linear inverse scattering model have been performed on the data.

Published
2021
Full Text
View/download PDF

53. Digestibility, toxicity and metabolic effects of rapeseed and sunflower protein hydrolysates in mice

Author

Donatella Canistro, Fabio Vivarelli, Luisa Ugolini, Carlo Pinna, Monica Grandi, Ippazio Cosimo Antonazzo, Silvia Cirillo, Andrea Sapone, Susanna Cinti, Luca Lazzeri, Emanuele Conte, and Giacomo Biagi

Subjects
Mice, protein, hydrolysate, rapeseed, sunflower, toxicity, study, Animal culture, SF1-1100
Abstract

The digestibility (in vitro), toxicity and metabolic effects of rapeseed (RPH) and sunflower (SPH) protein hydrolysates have been evaluated in a murine animal model. The enzyme Alcalase® was employed to obtain a mild enzymatic hydrolysis of rapeseed and sunflower defatted seed meals (DSM) protein isolates. Both hydrolysates showed higher in vitro digestibility than the respective DSM, presumably as a consequence of the hydrolysis process that they had undergone. In vivo, RPH and SPH were well tolerated. Body and organ weights, biochemical blood parameters from treated male mice were comparable to controls. Food intake was regular in RPH and SPH animals, suggesting a good palatability of the hydrolysates. Not relevant perturbations of the principal hepatic and renal drug metabolism enzymes were observed in RPH or SPH mice. In conclusion, protein hydrolysates from sunflower and rapeseed DSM did not determine relevant toxicological effects; therefore, they could be considered as alternative protein sources and/or food ingredients.

Published
2017
Full Text
View/download PDF

54. Long-acting injectable antipsychotics: Six-month follow-up of new outpatient treatments in Bologna Community Mental Health Centres.

Author

Lorenzo Berardi, Ippazio Cosimo Antonazzo, Carlo Piccinni, Emanuel Raschi, Emanuele Forcesi, Angelo Fioritti, Domenico Berardi, Fabrizio De Ponti, Antonella Piazza, and Elisabetta Poluzzi

Subjects
Medicine, Science
Abstract

PurposeThis study aims to describe factors associated to treatment continuity and psychiatric relapses in patients treated with Long Acting Injectable antipsychotics (LAIs) in Bologna Community Mental Health Centers (CMHCs).MethodsNew LAI treatments administered between July 1, 2010 and June 30, 2015 in CMHCs were selected. The cohort was followed-up for 6 months; predictors of continuity and psychiatric admissions were investigated by using logistic regression- and Cox- analysis respectively.ResultsAmong the cohort of 1 070 patients, only 222 (21%) continued LAI treatment during the follow-up. LAI continuity was higher with first generation agents (OR: 1.71, 95%CI 1.18-2.49) and in case of previous psychiatric hospitalizations (OR 2.00, 95%CI 1.47-2.74). Incidence of psychiatric hospital admissions showed a sharp reduction in the follow-up compared with 6-month period before initiation (from 458 to 212), and was associated with previous psychiatric hospitalizations (HR 3.20, 95%CI 2.22-4.59), immigration (HR 3.13, 95%CI 1.28-7.69) and LAI discontinuation (HR 1.14, 95%Cl 1.01-1.97).ConclusionsPsychiatric hospital admission before LAI initiation was the main predictor both of LAI continuity and hospitalization during the follow-up.

Published
2019
Full Text
View/download PDF

56. A cost-consequence analysis of adding pertuzumab to the neoadjuvant combination therapy in HER2-positive high-risk early breast cancer in Italy.

Author

Zambelli, Alberto, Cazzaniga, Marina, La Verde, Nicla, Munzone, Elisabetta, Antonazzo, Ippazio Cosimo, Mantovani, Lorenzo Giovanni, Di Cosimo, Serena, Mancuso, Anna, Generali, Daniele, and Cortesi, Paolo Angelo

Subjects
NEOADJUVANT chemotherapy, HER2 positive breast cancer, BREAST cancer, ECONOMIC impact, DIRECT costing, HORMONE receptor positive breast cancer
Abstract

Clinical trials confirmed the beneficial effects of adding pertuzumab (P) to the combination of trastuzumab-chemotherapy (TC) in the (neo)adjuvant setting of high-risk HER2-positive early breast cancer (HER2+BC). We evaluated the clinical, economic and societal impact of adding pertuzumab to neoadjuvant TC combination (TPC) in Italy. A cost-consequence analysis comparing TPC vs. TC was performed developing a cohort-based multi-state Markov model to estimate the clinical, societal and economic impact of the neoadjuvant therapy of TPC versus TC in HER2+BC at high-risk of recurrence. The model works on a cycle length of 1 month and 5-years-time horizon. Literature review-based data were used to populate the model. The following clinical and economic outcomes were estimated: cumulative incidence of loco-regional/distant recurrences, life of years and QALY and both direct and indirect costs (€). Finally, sensitivity analyses were performed. TPC was associated with a 75,630 € saved of direct costs. Specifically, it was associated with an initial increase of treatment costs (+4.8%) followed by reduction of recurrence management cost (−20.4%). TPC was also associated with an indirect cost reduction of 1.40%, as well as decreased incidence of distant recurrence (−20.14%), days of work lost (−1.53%) and days lived with disability (−0.50%). Furthermore, TPC reported 10,47 QALY gained (+2.77%) compared to TC. The probability to achieve the pathological complete response (pCR) was the parameter that mostly affected the results in the sensitivity analysis. Our findings suggested that TPC combination could be a cost-saving option in patients with HER2+BC at high-risk of recurrence. • TPC in the (neo)adjuvant setting is an effective treatment in high-risk HER2-positive early breast cancer. • TPC in the (neo)adjuvant setting is reimbursed in many European countries but not in Italy. • In our analysis, TPC was associated with a 124,956 € saved per 100 treated patients over 5-year time horizon compared to TC. • TPC showed a reduction of distant recurrence (−20.14%), days of work lost (−1.53%) and days lived with disability (−0.50%). • TPC showed a cost-saving profile in patients with HER2-positive early BC at high-risk of recurrence compared to TC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

59. Mode of birth in women with low-lying placenta: protocol for a prospective multicentre 1:3 matched case-control study in Italy (the MODEL-PLACENTA study)

Author

Ornaghi, S, Colciago, E, Vaglio Tessitore, I, Abbamondi, A, Antolini, L, Locatelli, A, Inversetti, A, Pintucci, A, Cetin, I, Bracco, B, Fabbri, E, Sala, V, Meroni, M, Volpe, G, Benedetti, S, Bulfoni, C, Marconi, A, Lagrasta, F, Paolini, C, Mazza, E, Candiani, M, Valsecchi, L, Smid, M, Pasi, F, Pozzoni, M, Castoldi, M, Vignali, M, Dal Molin, G, Guarano, A, Pellegrino, A, Callegari, C, Betti, M, Lazzarin, S, Prefumo, F, Zanardini, C, Parolin, V, Catalano, A, Barbolini, E, Antonazzo, P, Pignatti, L, Tintoni, M, Spelzini, F, Martinelli, A, Facchinetti, F, Chiossi, G, Vergani, P, Ornaghi S., Colciago E., Vaglio Tessitore I., Abbamondi A., Antolini L., Locatelli A., Inversetti A., Pintucci A., Cetin I., Bracco B., Fabbri E., Sala V., Meroni M., Volpe G., Benedetti S., Bulfoni C., Marconi A., Lagrasta F., Paolini C. L., Mazza E., Candiani M., Valsecchi L., Smid M., Pasi F., Pozzoni M., Castoldi M., Vignali M., Dal Molin G., Guarano A., Pellegrino A., Callegari C., Betti M., Lazzarin S., Prefumo F., Zanardini C., Parolin V., Catalano A., Barbolini E., Antonazzo P., Pignatti L., Tintoni M., Spelzini F., Martinelli A., Facchinetti F., Chiossi G., Vergani P., Ornaghi, S, Colciago, E, Vaglio Tessitore, I, Abbamondi, A, Antolini, L, Locatelli, A, Inversetti, A, Pintucci, A, Cetin, I, Bracco, B, Fabbri, E, Sala, V, Meroni, M, Volpe, G, Benedetti, S, Bulfoni, C, Marconi, A, Lagrasta, F, Paolini, C, Mazza, E, Candiani, M, Valsecchi, L, Smid, M, Pasi, F, Pozzoni, M, Castoldi, M, Vignali, M, Dal Molin, G, Guarano, A, Pellegrino, A, Callegari, C, Betti, M, Lazzarin, S, Prefumo, F, Zanardini, C, Parolin, V, Catalano, A, Barbolini, E, Antonazzo, P, Pignatti, L, Tintoni, M, Spelzini, F, Martinelli, A, Facchinetti, F, Chiossi, G, Vergani, P, Ornaghi S., Colciago E., Vaglio Tessitore I., Abbamondi A., Antolini L., Locatelli A., Inversetti A., Pintucci A., Cetin I., Bracco B., Fabbri E., Sala V., Meroni M., Volpe G., Benedetti S., Bulfoni C., Marconi A., Lagrasta F., Paolini C. L., Mazza E., Candiani M., Valsecchi L., Smid M., Pasi F., Pozzoni M., Castoldi M., Vignali M., Dal Molin G., Guarano A., Pellegrino A., Callegari C., Betti M., Lazzarin S., Prefumo F., Zanardini C., Parolin V., Catalano A., Barbolini E., Antonazzo P., Pignatti L., Tintoni M., Spelzini F., Martinelli A., Facchinetti F., Chiossi G., and Vergani P.

Abstract

Introduction The term placenta praevia defines a placenta that lies over the internal os, whereas the term low-lying placenta identifies a placenta that is partially implanted in the lower uterine segment with the inferior placental edge located at 1-20 mm from the internal cervical os (internal-os-distance). The most appropriate mode of birth in women with low-lying placenta is still controversial, with the majority of them undergoing caesarean section. The current project aims to evaluate the rate of vaginal birth and caesarean section in labour due to bleeding by offering a trial of labour to all women with an internal-os-distance >5 mm as assessed by transvaginal sonography in the late third trimester. Methods and analysis The MODEL-PLACENTA is a prospective, multicentre, 1:3 matched case-control study involving 17 Maternity Units across Lombardy and Emilia-Romagna regions, Italy. The study includes women with a placenta located in the lower uterine segment at the second trimester scan. Women with a normally located placenta will be enrolled as controls. A sample size of 30 women with an internal-os-distance >5 mm at the late third trimester scan is needed at each participating Unit. Since the incidence of low-lying placenta decreases from 2% in the second trimester to 0.4% at the end of pregnancy, 150 women should be recruited at each centre at the second trimester scan. A vaginal birth rate ≥60% in women with an internal-os-distance >5 mm will be considered appropriate to start routinely admitting to labour these women. Ethics and dissemination Ethical approval for the study was given by the Brianza Ethics Committee (No 3157, 2019). Written informed consent will be obtained from study participants. Results will be disseminated by publication in peer-reviewed journals and presentation in international conferences. Trial registration number NCT04827433 (pre-results stage)

Published
2021

60. Some Theoretical Insights on Social Movements and Resistance Practices in the Era of De-Politicization of Representative Politics

Author

Fabio de Nardis and Luca Antonazzo

Subjects
Sociology (General), HM401-1281
Abstract

The global economic crisis of 2008 has fostered a new wave of de-politicization intended as the shifting of national policy making from the public political arena to the field of extra-political supranational and international actors. The public policy making has become tightly linked to criteria that are much more economic than political. This change has provoked a consequent mutation in the nature and behavior of social movements which has result in different kinds of crossbreeding. Traditional social movements with their State-addressed requests have given way to new forms of social conflict that do not directly address to the national government. These new forms of mobilization act primarily in the form of direct social actions aimed at impacting directly on the economy and the environment. The common element of such experiences can be identified in the mix of resilience and resistance that they express.

Published
2017
Full Text
View/download PDF

62. Pseudo-Mannosylated DC-SIGN Ligands as Potential Adjuvants for HIV Vaccines

Author

Angela Berzi, Norbert Varga, Sara Sattin, Patrizio Antonazzo, Mara Biasin, Irene Cetin, Daria Trabattoni, Anna Bernardi, and Mario Clerici

Subjects
vaccine, HIV-1, adjuvant, DC-SIGN, innate immunity, glycomimetic compounds, Microbiology, QR1-502
Abstract

The development of new and effective adjuvants may play a fundamental role in improving HIV vaccine efficacy. New classes of vaccine adjuvants activate innate immunity receptors, notably toll like receptors (TLRs). Adjuvants targeting the C-Type lectin receptor DC-SIGN may be alternative or complementary to adjuvants based on TRL activation. Herein we evaluate the ability of the glycomimetic DC-SIGN ligand Polyman 19 (PM 19) to modulate innate immune responses. Results showed that PM 19 alone, or in combination with TLR agonists, induces the expression of cytokines, β chemokines and co-stimulatory molecules that may, in turn, modulate adaptive immunity and exert anti-viral effects. These results indicate that the suitability of this compound as a vaccine adjuvant should be further evaluated.

Published
2014
Full Text
View/download PDF

63. Heterotopic pregnancy in HIV women

Author

Valeria Savasi, Patrizio Antonazzo, and Carlo Personeni

Subjects
Medicine (General), R5-920
Abstract

Heterotopic pregnancy occurs when intrauterine and ectopic pregnancy are concomitant; overall rate rises from 1/30.000 to 1.5/1000 in assisted reproductive technology pregnancies. HIV (human immunodeficiency virus) patients are at increased risk of heterotopic pregnancies due to the greater frequency of assisted reproductive technology and pelvic inflammatory disease. We report the first case of heterotopic pregnancy in HIV woman.

Published
2016
Full Text
View/download PDF

64. Raphanus sativus cv. Sango Sprout Juice Decreases Diet-Induced Obesity in Sprague Dawley Rats and Ameliorates Related Disorders.

Author

Fabio Vivarelli, Donatella Canistro, Andrea Sapone, Gina Rosalinda De Nicola, Clara Babot Marquillas, Renato Iori, Ippazio Cosimo Antonazzo, Fabio Gentilini, and Moreno Paolini

Subjects
Medicine, Science
Abstract

BACKGROUND:Obesity is recognized as a leading global health problem, correlated with an increased risk for several chronic diseases. One strategy for weight control management includes the use of vegetables rich in bioactive compounds to counteract weight gain, improve the antioxidant status and stimulate lipid catabolism. AIM OF THE STUDY:The aim of this study was to investigate the role of Raphanus sativus Sango sprout juice (SSJ), a Brassica extraordinarily rich in anthocyanins (AC) and isothiocyanates (ITCs), in a non-genetic model of obesity (high fat diet-HFD induced). METHODS:Control groups were fed with HFD or regular diet (RD). After a 10-week period, animals were assigned to experimental units and treated by gavage for 28 days as follows: HFD and RD control groups (rats fed HFD or RD and treated with vehicle only) and HFD-treated groups (rats fed HFD and treated with 15, 75 or 150 mg/kg b.w. of SSJ). Body weight and food consumption were recorded and serum lipid profile was measured (total cholesterol, triglycerides, and non-esterified fatty acids). Hepatic phase-I, phase-II as well as antioxidant enzymatic activities were assessed. RESULTS:SSJ lowered total cholesterol level, food intake and liver weight compared with HFD rodents. SSJ at medium dose proved effective in reducing body-weight (~19 g reduction). SSJ was effective in up-regulating the antioxidant enzymes catalase, NAD(P)H:quinone reductase, oxidised glutathione reductase and superoxide dismutase, which reached or exceeded RD levels, as well as the phase II metabolic enzyme UDP-glucuronosyl transferase (up to about 43%). HFD up-regulated almost every cytochrome P450 isoform tested, and a mild down-regulation to baseline was observed after SSJ intervention. CONCLUSION:This work reveals, for the first time, the antioxidant, hypolipidemic and antiobesity potential of SSJ, suggesting its use as an efficient new functional food/nutraceutical product.

Published
2016
Full Text
View/download PDF

65. Harlequin Color Change: Neonatal Case Series and Brief Literature Review

Author

Enrico Valerio, Alessia Barlotta, Eleonora Lorenzon, Livio Antonazzo, and Mario Cutrone

Subjects
harlequin color change, preterm, neonate, infant, dermatology, Gynecology and obstetrics, RG1-991
Abstract

Abstract First clinical report of Harlequin color change (HCC) phenomenon came in 1952 from Neligan and Strang. Since then, HCC has been described in a fairly broad number of clinical reports involving neonates, infants, children, and adult patients. We here present a small case series of HCC occurring in neonates, pointing out three of the different possible presentations (hemifacial, patchy scattered across the whole body, and hemiscrotal) of this phenomenon. A brief discussion and literature review encompassing epidemiology, clinical features, physiopathology, associated conditions, and differential diagnoses of HCC is then presented. In most cases, HCC represents a benign, idiopathic, and rapidly autoresolutive phenomenon, with no need for treatment. Some drugs (especially anesthetics and prostaglandin E) are thought to enhance HCC expression through their influence on the capillary tone in the peripheral vascular bed; this effect is anyway promptly reversible with drug withdrawal. Only in rare circumstances, HCC may act as a clue for serious central nervous system disorders (e.g., meningitis; hypothalamic, brain stem, or sympathetic nervous system lesions); anyway, in these rare occurrences HCC always represents an epiphenomenon of the disease, never acting as the sole sign of the underlying disorder.

Published
2015
Full Text
View/download PDF

69. Lipoprotein Lipase (LPL) mRNA Expression in Placentas from Normal and IUGR (Intrauterine Growth Restricted) Pregnancies by Real-Time PCR.

Author

Tabano, S., Alvino, G., Antonazzo, P., Cozzi, V., Grati, F., Miozzo, M., Cetin, I., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Koletzko, Berthold, editor, Dodds, Peter, editor, Akerblom, Hans, editor, and Ashwell, Margaret, editor

Published
2005
Full Text
View/download PDF

70. Silenzio, ordine e solitudine

Author

Lucia C. Antonazzo

Subjects
imaginaire symbolique, imaginaire social, écritures de soi, poétique de soi, littératures personnelles, autobiographie, roman autobiographique, autofiction, souffrances sociales, Social Sciences
Abstract

Il racconto breve Sessizlik (Il silenzio, 1980) fa parte del libro Kötü bir yaratik di Zeynep Avci Karabey, scrittrice e giornalista turca. In Sessizlik è affrontata la tematica dell’ordine domestico come dovere della donna nella dimensione quotidiana dello spazio privato. Dal patriarcato nasce una visione del mondo e delle cose che presenta come naturali usi e tradizioni che non lo sono affatto, ma che sono soltanto il frutto di sistemi filosofici, politici e sociali. L’ordine sociale agisce sugli uomini e sulle donne con effetti durevoli, cioè uomini e donne reagiscono alle situazioni in modo apparentemente spontaneo, ma che riflette schemi fissi. L’ordine non è sempre garantito con forme di violenza fisica o psicologica, ma con forme più sottili di violenza simbolica.

Published
2010

71. Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019

Author

Cousin, Ewerton, Duncan, Bruce B, Stein, Caroline, Ong, Kanyin Liane, Vos, Theo, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abdelmasseh, Michael, Abdoli, Amir, Abd-Rabu, Rami, Abolhassani, Hassan, Abu-Gharbieh, Eman, Accrombessi, Manfred Mario Kokou, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Agarwal, Gina, Agrawaal, Krishna K, Agudelo-Botero, Marcela, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmadi, Ali, Ahmed, Ali, Ahmed Salih, Yusra, Akande-Sholabi, Wuraola, Akram, Tayyaba, Al Hamad, Hanadi, Al-Aly, Ziyad, Alcalde-Rabanal, Jacqueline Elizabeth, Alipour, Vahid, Aljunid, Syed Mohamed, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amini, Saeed, Ancuceanu, Robert, Andrei, Tudorel, Andrei, Catalina Liliana, Anjana, Ranjit Mohan, Ansar, Adnan, Antonazzo, Ippazio Cosimo, Antony, Benny, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arizmendi, Damian, Armocida, Benedetta, Artamonov, Anton A, Arulappan, Judie, Aryan, Zahra, Asgari, Samaneh, Ashraf, Tahira, Astell-Burt, Thomas, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Ayanore, Martin Amogre, Badiye, Ashish D, Baig, Atif Amin, Bairwa, Mohan, Baker, Jennifer L, Baltatu, Ovidiu Constantin, Banik, Palash Chandra, Barnett, Anthony, Barone, Mark Thomaz Ugliara, Barone-Adesi, Francesco, Barrow, Amadou, Bedi, Neeraj, Belete, Rebuma, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Bennett, Derrick A, Bensenor, Isabela M, Beran, David, Bhagavathula, Akshaya Srikanth, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bijani, Ali, Bikbov, Boris, Birara, Setognal, Bodolica, Virginia, Bonny, Aime, Brenner, Hermann, Briko, Nikolay Ivanovich, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Campos-Nonato, Ismael R, Cao, Yin, Cao, Chao, Cerin, Ester, Chakraborty, Promit Ananyo, Chandan, Joht Singh, Chattu, Vijay Kumar, Chen, Simiao, Choi, Jee-Young Jasmine, Choudhari, Sonali Gajanan, Chowdhury, Enayet Karim, Chu, Dinh-Toi, Corso, Barbara, Dadras, Omid, Dai, Xiaochen, Damasceno, Albertino Antonio Moura, Dandona, Lalit, Dandona, Rakhi, Dávila-Cervantes, Claudio Alberto, De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Dhamnetiya, Deepak, Diaz, Daniel, Ebtehaj, Sanam, Edinur, Hisham Atan, Eftekharzadeh, Sahar, El Sayed, Iman, Elgendy, Islam Y, Elhadi, Muhammed, Elmonem, Mohamed A, Faisaluddin, Mohammed, Farooque, Umar, Feng, Xiaoqi, Fernandes, Eduarda, Fischer, Florian, Flood, David, Freitas, Marisa, Gaal, Peter Andras, Gad, Mohamed M, Gaewkhiew, Piyada, Getacher, Lemma, Ghafourifard, Mansour, Ghanei Gheshlagh, Reza, Ghashghaee, Ahmad, Ghith, Nermin, Ghozali, Ghozali, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Glushkova, Ekaterina Vladimirovna, Golechha, Mahaveer, Gopalani, Sameer Vali, Guimarães, Rafael Alves, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Vivek Kumar, Gupta, Veer Bala, Gupta, Sapna, Habtewold, Tesfa Dejenie, Hafezi-Nejad, Nima, Halwani, Rabih, Hanif, Asif, Hankey, Graeme J, Haque, Shafiul, Hasaballah, Ahmed I, Hasan, Syed Shahzad, Hashi, Abdiwahab, Hassanipour, Soheil, Hay, Simon I, Hayat, Khezar, Heidari, Mohammad, Hossain, Mohammad Bellal Hossain, Hossain, Sahadat, Hosseini, Mostafa, Hoveidamanesh, Soodabeh, Huang, Junjie, Humayun, Ayesha, Hussain, Rabia, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Inbaraj, Leeberk Raja, Iqbal, Usman, Islam, Md Shariful, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Itumalla, Ramaiah, Iwagami, Masao, Iyamu, Ihoghosa Osamuyi, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jayawardena, Ranil, Jha, Ravi Prakash, John, Oommen, Jonas, Jost B, Joo, Tamas, Kabir, Ali, Kalhor, Rohollah, Kamath, Ashwin, Kanchan, Tanuj, Kandel, Himal, Kapoor, Neeti, Kayode, Gbenga A, Kebede, Sewnet Adem, Keshavarz, Pedram, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khan, Moien AB, Khan, Md Nuruzzaman, Khan, Maseer, Khater, Amir M, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Sezer, Kisa, Adnan, Kivimäki, Mika, Korshunov, Vladimir Andreevich, Korzh, Oleksii, Koyanagi, Ai, Krishan, Kewal, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Nithin, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Larsson, Anders O, Lasrado, Savita, Lee, Wei-Chen, Lee, Chiachi Bonnie, Lee, Paul H, Lee, Shaun Wen Huey, Li, Ming-Chieh, Lim, Stephen S, Lim, Lee-Ling, Lucchetti, Giancarlo, Majeed, Azeem, Malik, Ahmad Azam, Mansouri, Borhan, Mantovani, Lorenzo Giovanni, Martini, Santi, Mathur, Prashant, McAlinden, Colm, Mehedi, Nafiul, Mekonnen, Teferi, Menezes, Ritesh G, Mersha, Amanual Getnet, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Mirica, Andreea, Mirrakhimov, Erkin M, Mirza, Agha Zeeshan, Mithra, Prasanna, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Arif, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Moradpour, Farhad, Moradzadeh, Rahmatollah, Mostafavi, Ebrahim, Mueller, Ulrich Otto, Murray, Christopher J L, Mustafa, Ahmad, Nagel, Gabriele, Nangia, Vinay, Naqvi, Atta Abbas, Nayak, Biswa Prakash, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ruxandra Irina, Neupane Kandel, Sandhya, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Noubiap, Jean Jacques, Nowak, Christoph, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oguntade, Ayodipupo Sikiru, Ojo, Temitope T, Olagunju, Andrew T, Onwujekwe, Obinna E, Ortiz, Alberto, Owolabi, Mayowa O, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pardhan, Shahina, Parekh, Tarang, Parvizi, Mojtaba, Pepito, Veincent Christian Filipino, Perianayagam, Arokiasamy, Petcu, Ionela-Roxana, Pilania, Manju, Podder, Vivek, Polibin, Roman V, Postma, Maarten J, Prashant, Akila, Rabiee, Navid, Rabiee, Mohammad, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rahman, Md. Mosfequr, Rahman, Mosiur, Rahmawaty, Setyaningrum, Rajai, Nazanin, Ram, Pradhum, Rana, Juwel, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Satish, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Renzaho, Andre M N, Rezaei, Nima, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Daniela, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rohloff, Peter, Rwegerera, Godfrey M, Ryan, Paul MacDaragh, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Saddik, Basema, Saeedi Moghaddam, Sahar, Sahebkar, Amirhossein, Sahoo, Harihar, Saif-Ur-Rahman, KM, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Sanabria, Juan, Santric-Milicevic, Milena M, Sathian, Brijesh, Sathish, Thirunavukkarasu, Schlaich, Markus P, Seidu, Abdul-Aziz, Šekerija, Mario, Senthil Kumar, Nachimuthu, Seylani, Allen, Shaikh, Masood Ali, Shamshad, Hina, Shawon, Md Shajedur Rahman, Sheikhbahaei, Sara, Shetty, Jeevan K, Shiri, Rahman, Shivakumar, K M, Shuval, Kerem, Singh, Jasvinder A, Singh, Ambrish, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sofi-Mahmudi, Ahmad, Soheili, Amin, Sun, Jing, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tadbiri, Hooman, Tadesse, Eyayou Girma, Tariqujjaman, Md., Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thomas, Nihal, Timalsina, Binod, Tobe-Gai, Ruoyan, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tripathy, Jaya Prasad, Tudor Car, Lorainne, Tusa, Biruk Shalmeno, Uddin, Riaz, Upadhyay, Era, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasankari, Tommi Juhani, Verma, Madhur, Villalobos-Daniel, Victor E, Vladimirov, Sergey Konstantinovitch, Vo, Bay, Vu, Giang Thu, Vukovic, Rade, Waheed, Yasir, Wamai, Richard G, Werdecker, Andrea, Wickramasinghe, Nuwan Darshana, Winkler, Andrea Sylvia, Wubishet, Befikadu Legesse, Xu, Xiaoyue, Xu, Suowen, Yahyazadeh Jabbari, Seyed Hossein, Yatsuya, Hiroshi, Yaya, Sanni, Yazie, Taklo Simeneh Yazie, Yi, Siyan, Yonemoto, Naohiro, Yunusa, Ismaeel, Zadey, Siddhesh, Zaman, Sojib Bin, Zamanian, Maryam, Zamora, Nelson, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhong, Chenwen, Zmaili, Mohammad, Zumla, Alimuddin, Naghavi, Mohsen, and Schmidt, Maria Inês

Abstract

Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.

Published
2022
Full Text
View/download PDF

73. Assessing intravitreal anti-VEGF drug safety using real-world data: methodological challenges in observational research

Author

Scondotto, Giulia, Crisafulli, Salvatore, Antonazzo, Ippazio Cosimo, Virgili, Gianni, Trifirò, Gianluca, and Sultana, Janet

Abstract

ABSTRACTIntroductionIt is generally acknowledged that the ocular safety profile of intravitreal anti-VEGF drugs is acceptable, while the burden of systemic safety of these intravitreal agents is still being debated. The evaluation of the systemic safety of these drugs using real-world data (RWD), such as spontaneous reporting systems (SRS), electronic medical records (EMRs) and claims databases has several advantages, including the capture of outcomes among real-world populations over long observation periods. Nevertheless, there is a relatively small body of research exploring the post-marketing safety of these drugs.Areas coveredThe aim of this scoping review is to outline and discuss some of the methodological challenges to be faced when investigating the systemic safety of intravitreal anti-VEGF drugs using different sources of RWD.Expert opinionSuch challenges include the selection of the most suitable data source, taking into account how well drug utilization is captured and whether the outcomes and covariates of interest can be captured. The strengths and limitations of some analytic methods that can be used to quantify risk, such as the intention-to-treat approach and the as-treated approach, complement each other, and using these together provides a more balanced analysis.

Published
2022
Full Text
View/download PDF

74. Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems.

Author

Gatti, Milo, Ippoliti, Ilaria, Poluzzi, Elisabetta, Antonazzo, Ippazio Cosimo, Moro, Paola Angela, Moretti, Ugo, Menniti-Ippolito, Francesca, Mazzanti, Gabriela, De Ponti, Fabrizio, and Raschi, Emanuel

Abstract

Alpha-lipoic acid (ALA)-containing dietary supplements are widely used in clinical practice, although their safety assessment is under-investigated. We characterize the safety profile of ALA-containing products by analysing spontaneous reports of suspected adverse reactions (ARs). Suspected ARs to ALA-containing products were extracted from the Italian Phytovigilance System (IPS), and scrutinized in terms of seriousness and causality (through WHO UMC system), with a specific focus on important (IMEs) and designated medical events (DMEs). To characterize the reporting profile from an international perspective, the WHO-VigiBase was also queried. From March 2002 to February 2020, out of 2147 total reports, 116 reports concerning 212 ARs to ALA-containing products were collected. Women were involved in 68.1% of cases. Skin (44.9%) and gastrointestinal disorders (10.8%) were the most frequently represented ARs. Causality assessment resulted as definite (15), probable (35), possible (24), unlikely (5), and unclassifiable (37). In 70% of cases, events occurred within 30 days of ALA use. Forty-five reports were serious (38.8%), being insulin autoimmune syndrome the most frequently reported (N = 10). IMEs were recorded in 20 cases, including four DMEs (3 angioedema and one anaphylactic shock). Similar distribution emerged from the 5641 reports in the WHO-VigiBase. The remarkable reporting of unpredictable skin, immune and hepatic ARs, coupled with seriousness, strong causality and early onset, calls for a) careful risk-benefit assessment of ALA-containing products by regulators; b) awareness and monitoring by clinicians and c) continuous vigilance of their safety profile through valuable spontaneous reporting systems such as IPS. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

77. FlyBase: updates to the Drosophilagenes and genomes database

Author

Öztürk-Çolak, Arzu, Marygold, Steven J, Antonazzo, Giulia, Attrill, Helen, Goutte-Gattat, Damien, Jenkins, Victoria K, Matthews, Beverley B, Millburn, Gillian, dos Santos, Gilberto, and Tabone, Christopher J

Abstract

FlyBase (flybase.org) is a model organism database and knowledge base about Drosophila melanogaster, commonly known as the fruit fly. Researchers from around the world rely on the genetic, genomic, and functional information available in FlyBase, as well as its tools to view and interrogate these data. In this article, we describe the latest developments and updates to FlyBase. These include the introduction of single-cell RNA sequencing data, improved content and display of functional information, updated orthology pipelines, new chemical reports, and enhancements to our outreach resources.

Published
2024
Full Text
View/download PDF

79. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Murray, Christopher J L, Aravkin, Aleksandr Y, Zheng, Peng, Abbafati, Cristiana, Abbas, Kaja M, Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abualhasan, Ahmed, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I, Adabi, Maryam, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Adham, Davoud, Advani, Shailesh M, Agarwal, Gina, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alemu, Biresaw wassihun, Alhabib, Khalid F, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M, Alonso, Jordi, Altirkawi, Khalid A, Amini-Rarani, Mostafa, Amiri, Fatemeh, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Ariani, Filippo, Armoon, Bahram, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Atnafu, Desta Debalkie, Atout, Maha Moh'd Wahbi, Ausloos, Floriane, Ausloos, Marcel, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Badawi, Alaa, Badiye, Ashish D, Bahrami, Mohammad Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M, Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H, Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K, Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Barthelemy, Celine M, Barua, Lingkan, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Becker, Jacob S, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michellr L, Bennitt, Fiona B, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bohlouli, Somayeh, Bohluli, Mehdi, Boon-Dooley, Alexandra S, Borges, Guilherme, Borzì, Antonio Maria, Borzouei, Shiva, Bosetti, Cristina, Boufous, Soufiane, Braithwaite, Dejana, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briant, Paul Svitil, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B, Bryazka, Dana, Bumgarner, Blair R, Burkart, Katrin, Burnett, Richard Thomas, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cahill, Leah E, Cámera, Luis LA Alberto, Campos-Nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Castro, Franz, Causey, Kate, Cederroth, Christopher R, Cercy, Kelly M, Cerin, Ester, Chandan, Joht Singh, Chang, Kai-Lan, Charlson, Fiona J, Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-Ochir, Odgerel, Cho, Daniel Youngwhan, Choi, Jee-Young Jasmine, Christensen, Hanne, Chu, Dinh-Toi, Chung, Michael T, Chung, Sheng-Chia, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Classen, Thomas Khaled Dwayne, Cohen, Aaron J, Compton, Kelly, Cooper, Owen R, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Cross, Di H, Cruz, Jessica A, Dahlawi, Saad M A, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Danielsson, Anna-Karin, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K, Das Gupta, Rajat, das Neves, José, Dávila-Cervantes, Claudio Alberto, Davitoiu, Dragos Virgil, De Leo, Diego, Degenhardt, Louisa, DeLang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dibaji Forooshani, Zahra Sadat, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Dorostkar, Fariba, Doshmangir, Leila, Driscoll, Tim Robert, Duncan, Bruce B, Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Edvardsson, David, El Nahas, Nevine, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Elgendy, Islam Y, El-Jaafary, Shaimaa I, Elyazar, Iqbal RF, Emmons-Bell, Sophia, Erskine, Holly E, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Estep, Kara, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Fareed, Mohammad, Faridnia, Roghiyeh, Farioli, Andrea, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, Feigin, Valery L, Feldman, Rachel, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Giannina, Ferrari, Alize J, Ferreira, Manuela L, Filip, Irina, Fischer, Florian, Fisher, James L, Flor, Luisa Sorio, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Force, Lisa M, Foroutan, Masoud, Franklin, Richard Charles, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M, Gad, Mohamed M, Gakidou, Emmanuela, Gallus, Silvano, Garcia-Basteiro, Alberto L, Gardner, William M, Geberemariyam, Biniyam Sahiledengle, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geremew, Abraham, Gershberg Hayoon, Anna, Gething, Peter W, Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Gill, Paramjit Singh, Ginindza, Themba G G, Giussani, Giorgia, Gnedovskaya, Elena V, Goharinezhad, Salime, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C, Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, Gupta, Tarun, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J, Halvaei, Iman, Hamadeh, Randah R, Hamidi, Samer, Hammer, Melanie S, Hankey, Graeme J, Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasanpoor, Edris, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Henrikson, Hannah J, Herbert, Molly E, Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R, Hoek, Hans W, Holla, Ramesh, Hoogar, Praveen, Hosgood, H Dean, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hsieh, Vivian Chia-rong, Hu, Guoqing, Hu, Kejia, Huda, Tanvir M, Humayun, Ayesha, Huynh, Chantal K, Hwang, Bing-Fang, Iannucci, Vincent C, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Ippolito, Helen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M Mofizul, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Ivers, Rebecca Q, Iwu, Chidozie C D, Iwu, Chinwe Juliana, Iyamu, Ihoghosa Osamuyi, Jaafari, Jalil, Jacobsen, Kathryn H, Jafari, Hussain, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalilian, Farzad, James, Spencer L, Janjani, Hosna, Javaheri, Tahereh, Javidnia, Javad, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Johansson, Lars, John, Oommen, John-Akinola, Yetunde O, Johnson, Catherine Owens, Jonas, Jost B, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalani, Hamed, Kalani, Rizwan, Kalankesh, Leila R, Kalhor, Rohollah, Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karch, André, Karim, Mohd Anisul, Kassa, Getachew Mullu, Katikireddi, Srinivasa Vittal, Kayode, Gbenga A, Kazemi Karyani, Ali, Keiyoro, Peter Njenga, Keller, Cathleen, Kemmer, Laura, Kendrick, Parkes J, Khalid, Nauman, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Maseer, Khatab, Khaled, Khater, Mona M, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khazaei, Salman, Kieling, Christian, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Knibbs, Luke D, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M, Kochhar, Sonali, Kopec, Jacek A, Korshunov, Vladimir Andreevich, Koul, Parvaiz A, Koyanagi, Ai, Kraemer, Moritz U G, Krishan, Kewal, Krohn, Kris J, Kromhout, Hans, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Vivek, Kurmi, Om P, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lami, Faris Hasan, Landires, Iván, Lang, Justin J, Langan, Sinéad M, Larsson, Anders O, Lasrado, Savita, Lauriola, Paolo, Lazarus, Jeffrey V, Lee, Paul H, Lee, Shaun Wen Huey, LeGrand, Kate E, Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Li, Shanshan, Lim, Lee-Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Liu, Yang, Lo, Justin, Lopez, Alan D, Lopez, Jaifred Christian F, Lopukhov, Platon D, Lorkowski, Stefan, Lotufo, Paulo A, Lu, Alton, Lugo, Alessandra, Maddison, Emilie R, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Majeed, Azeem, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A, Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantilla Herrera, Ana M, Maravilla, Joemer C, Marks, Ashley, Martin, Randall V, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K, McAlinden, Colm, McGrath, John J, McKee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Memish, Ziad A, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R, Mills, Edward J, Mini, GK, Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mithra, Prasanna, Moazen, Babak, Mohammad, Dara K, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Mooney, Meghan D, Moradi, Ghobad, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F, Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mullany, Erin C, Musa, Kamarul Imran, Muthupandian, Saravanan, Nabhan, Ashraf F, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Naserbakht, Morteza, Nayak, Vinod C, Negoi, Ionut, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Nigatu, Yeshambel T, Nikbakhsh, Rajan, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Norrving, Bo, Noubiap, Jean Jacques, Nowak, Christoph, Nunez-Samudio, Virginia, Oţoiu, Adrian, Oancea, Bogdan, Odell, Christopher M, Ogbo, Felix Akpojene, Oh, In-Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omer, Muktar Omer, Ong, Kanyin L, Onwujekwe, Obinna E, Orpana, Heather M, Ortiz, Alberto, Osarenotor, Osayomwanbo, Osei, Frank B, Ostroff, Samuel M, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandey, Anamika, Parry, Charles D H, Pasovic, Maja, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Mona, Patten, Scott B, Patton, George C, Pazoki Toroudi, Hamidreza, Peden, Amy E, Pennini, Alyssa, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, David M, Pesudovs, Konrad, Pham, Hai Quang, Phillips, Michael R, Piccinelli, Cristiano, Pilz, Tessa M, Piradov, Michael A, Pirsaheb, Meghdad, Plass, Dietrich, Polinder, Suzanne, Polkinghorne, Kevan R, Pond, Constance Dimity, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Poznańska, Anna, Prada, Sergio I, Prakash, V, Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Chhabi Lal, Rao, Puja C, Rao, Sowmya J, Rashedi, Vahid, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawat, Ramu, Razo, Christian, Redford, Sofia Boston, Reiner, Robert C, Reitsma, Marissa Bettay, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Rhinehart, Phoebe-Anne, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Ribeiro, Daniela, Rickard, Jennifer, Rivera, Juan A, Roberts, Nicholas L S, Rodríguez-Ramírez, Sonia, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Sachdev, Perminder S, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi, Reza, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sajadi, S Mohammad, Salam, Nasir, Salamati, Payman, Salem, Hosni, Salem, Marwa R Rashad, Salimzadeh, Hamideh, Salman, Omar Mukhtar, Salomon, Joshua A, Samad, Zainab, Samadi Kafil, Hossein, Sambala, Evanson Zondani, Samy, Abdallah M, Sanabria, Juan, Sánchez-Pimienta, Tania G, Santomauro, Damian Francesco, Santos, Itamar S, Santos, João Vasco, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sarmiento-Suárez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saxena, Sonia, Schaeffer, Lauren E, Schiavolin, Silvia, Schlaich, Markus P, Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Schwebel, David C, Schwendicke, Falk, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serdar, Berrin, Serre, Marc L, Shadid, Jamileh, Shafaat, Omid, Shahabi, Saeed, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharafi, Kiomars, Sheikh, Aziz, Sheikhtaheri, Abbas, Shibuya, Kenji, Shield, Kevin David, Shigematsu, Mika, Shin, Jae Il, Shin, Min-Jeong, Shiri, Rahman, Shirkoohi, Reza, Shuval, Kerem, Siabani, Soraya, Sierpinski, Radoslaw, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, João Pedro, Simpson, Kyle E, Singh, Jasvinder A, Singh, Pushpendra, Skiadaresi, Eirini, Skou, Søren T, Skryabin, Valentin Yurievich, Smith, Emma U R, Soheili, Amin, Soltani, Shahin, Soofi, Moslem, Sorensen, Reed J D, Soriano, Joan B, Sorrie, Muluken Bekele, Soshnikov, Sergey, Soyiri, Ireneous N, Spencer, Cory N, Spotin, Adel, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stein, Caroline, Stein, Dan J, Steiner, Caitlyn, Stockfelt, Leo, Stokes, Mark A, Straif, Kurt, Stubbs, Jacob L, Sufiyan, Mu'awiyyah Babale, Suleria, Hafiz Ansar Rasul, Suliankatchi Abdulkader, Rizwan, Sulo, Gerhard, Sultan, Iyad, Szumowski, Łukasz, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tabuchi, Takahiro, Taherkhani, Amir, Tajdini, Masih, Takahashi, Ken, Takala, Jukka S, Tamiru, Animut Tagele, Taveira, Nuno, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tesema, Getayeneh Antehunegn, Tessema, Zemenu Tadesse, Thurston, George D, Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto Roberto, Tran, Bach Xuan, Travillian, Ravensara, Tsatsakis, Aristidis, Tudor Car, Lorainne, Tyrovolas, Stefanos, Uddin, Riaz, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Valdez, Pascual R, van Donkelaar, Aaron, Vasankari, Tommi Juhani, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Wang, Yafeng, Wang, Yuan-Pang, Watson, Alexandrea, Wei, Jingkai, Wei, Melissa Y Wei, Weintraub, Robert G, Weiss, Jordan, Werdecker, Andrea, West, J Jason, Westerman, Ronny, Whisnant, Joanna L, Whiteford, Harvey A, Wiens, Kirsten E, Wolfe, Charles D A, Wozniak, Sarah S, Wu, Ai-Min, Wu, Junjie, Wulf Hanson, Sarah, Xu, Gelin, Xu, Rixing, Yadgir, Simon, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yaminfirooz, Mousa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yeheyis, Tomas Y, Yilgwan, Christopher Sabo, Yilma, Mekdes Tigistu, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Bahman, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yu, Chuanhua, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Jeff T, Zhao, Xiu-Ju George, Zhao, Yingxi, Zhou, Maigeng, Ziapour, Arash, Zimsen, Stephanie R M, Brauer, Michael, Afshin, Ashkan, and Lim, Stephen S

Abstract

Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease.

Published
2020
Full Text
View/download PDF

81. Adverse events with sacubitril/valsartan in the real world: emerging signals to target preventive strategies from the FDA adverse event reporting system

Author

Gatti, Milo, Antonazzo, Ippazio Cosimo, Diemberger, Igor, De Ponti, Fabrizio, and Raschi, Emanuel

Abstract

Aims The aim of this study was to characterise clinical priority of adverse events with sacubitril/valsartan for targeting preventive measures.Methods We used the US Food and Drug Administration adverse event reporting system (worldwide pharmacovigilance database) to compare adverse events recording sacubitril/valsartan as suspect with other cardiovascular drugs. Disproportionality analyses were performed by calculating the reporting odds ratios, deemed significant when the lower limit of the 95% confidence interval was greater than 1. Clinical priority was assigned to adverse events with significant disproportionality by scoring (range 0–10 points) five features (number of events, magnitude of the lower limit of the 95% confidence interval, mortality frequency, important/designated medical event, biological plausibility).Results Sacubitril/valsartan was recorded in 20,021 reports, with 178 adverse events associated with significant disproportionality: 71.9%, 25.9% and 2.2% were classified as weak, moderate and strong clinical priorities, respectively. Increased reporting emerged for several cardiovascular adverse events, including ‘renal failure’ (N= 388; lower limit of the 95% confidence interval 2.26), ‘hyperkalaemia’ (314; 2.42) and ‘angioedema’ (309; 1.56). Sudden cardiac death (priority score 9 points) was the only designated medical event with strong clinical priority. Notably, sudden cardiac death occurred early after sacubitril/valsartan administration (average onset 124 days), with concomitant drugs known for pro-arrhythmic potential (e.g. amiodarone, escitalopram, mirtazapine, loop diuretics) in 26.2% of records.Conclusion The increased cardiovascular reporting of sacubitril/valsartan in the real world was largely predictable from pre-approval evidence, underlying disease and likely patients’ comorbidities. The unexpected reporting of sudden cardiac death occurred well before the complete development of positive electrical remodelling induced by sacubitril/valsartan, and calls for stringent clinical monitoring (to reduce the pro-arrhythmic burden related to co-medications), and further investigation on appropriate combination with other preventive measures.

Published
2024
Full Text
View/download PDF

82. Guidance Counseling Takes More Than a Band-Aid Approach.

Author

Antonazzo, Sister Dorothy and Payton, Debra H.

Abstract

Reports that St. Francis Central Catholic School (West Virginia) has been building a full-time counseling program for the last eight years. Stresses the importance of academic, developmental, emotional, and moral guidance for all students, noting that success has more to do with emotional well-being than intelligence. (NB)

Published
2001

84. Mitochondrial content and hepcidin are increased in obese pregnant mothers.

Author

Anelli, G. M., Cardellicchio, M., Novielli, C., Antonazzo, P., Mazzocco, M. I., Cetin, I., and Mandò, C.

Subjects
MITOCHONDRIAL DNA, HEPCIDIN, OVERWEIGHT women, PREGNANCY, SEXUAL dimorphism, OXIDATIVE stress, MITOCHONDRIAL pathology, DNA analysis, DNA metabolism, INFLAMMATION, MITOCHONDRIA, MOTHERS, OBESITY, PEPTIDES, PLACENTA, PREGNANCY complications, QUESTIONNAIRES, CASE-control method
Abstract

Objective: Maternal obesity is characterized by systemic low-grade inflammation and oxidative stress (OxS) with the contribution of fetal sex dimorphism. We recently described increased mitochondrial content (mtDNA) in placentas of obese pregnancies. Here, we quantify mtDNA and hepcidin as indexes of OxS and systemic inflammation in the obese maternal circulation.Methods: Forty-one pregnant women were enrolled at elective cesarean section: 16 were normal weight (NW) and 25 were obese (OB). Obese women were further classified according to the presence/absence of maternal gestational diabetes mellitus (GDM); [OB/GDM(-)]: n = 15, [OB/GDM(+)]: n = 10. mtDNA and hepcidin were evaluated in blood (real-time PCR) and plasma (ELISA).Results: mtDNA and hepcidin levels were significantly increased in OB/GDM(-) versus NW, significantly correlating with pregestational BMI. Male/female (M/F) ratio was equal in study groups, and overall F-carrying pregnancies showed significantly higher mtDNA and hepcidin levels than M-carrying pregnancies both in obese and normal weight mothers.Conclusions: Our results indicate a potential compensatory mechanism to increased obesity-related OxS and inflammation, indicated by the higher hepcidin levels found in obese mothers. Increased placental mitochondrial biogenesis, due to lipotoxic environment, may account for the greater mtDNA amount released in maternal circulation. This increase is namely related to F-carrying pregnancies, suggesting a gender-specific placental response. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

86. Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency.

Author

Novielli, Chiara, Mandò, Chiara, Tabano, Silvia, Anelli, Gaia M., Fontana, Laura, Antonazzo, Patrizio, Miozzo, Monica, and Cetin, Irene

Abstract

Introduction: Intrauterine growth restriction (IUGR) and preeclampsia (PE) are pregnancy disorders characterized by placental insufficiency with oxygen/nutrient restriction and oxidative stress, all influencing mitochondria functionality and number. Moreover, IUGR and PE fetuses are predisposed to diseases later in life, and this might occur through epigenetic alterations. Here we analyze content and methylation of mitochondrial DNA (mtDNA), for the first time in IUGR and PE singleton fetuses, to identify possible alterations in mtDNA levels and/or epigenetic control of mitochondrial loci relevant to replication (D-loop) and functionality (mt-TF/RNR1: protein synthesis, mt-CO1: respiratory chain complex).Methods: We studied 35 term and 8 preterm control, 31 IUGR, 17 PE/IUGR and 17 PE human singleton pregnancies with elective cesarean delivery. Fetal cord blood was collected and evaluated for biochemical parameters. Extracted DNA was subjected to Real-time PCR to assess mtDNA content and analyzed for D-loop, mt-TF/RNR1 and mt-CO1 methylation by bisulfite conversion and pyrosequencing.Results: mtDNA levels were increased in all pathologic groups compared to controls. Mitochondrial loci showed very low methylation levels in all samples; D-loop methylation was further decreased in the most severe cases and associated to umbilical vein pO2. mt-CO1 methylation levels inversely correlated to mtDNA content.Discussion: Increased mtDNA levels in IUGR, PE/IUGR and PE cord blood may denote a fetal response to placental insufficiency. Hypomethylation of D-loop, mt-TF/RNR1 and mt-CO1 loci confirms their relevance in pregnancy. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

89. Multiple sclerosis as an adverse drug reaction: clues from the FDA Adverse Event Reporting System

Author

Antonazzo, Ippazio Cosimo, Raschi, Emanuel, Forcesi, Emanuele, Riise, Trond, Bjornevik, Kjetil, Baldin, Elisa, De Ponti, Fabrizio, and Poluzzi, Elisabetta

Abstract

ABSTRACTBackground: Possible relationship between drug exposure and multiple sclerosis (MS) development is insufficiently investigated, and further challenged by the incomplete understanding of MS etiopathogenesis. The study aims to investigate whether drug exposure could contribute to MS, by analyzing worldwide spontaneous reporting archives of adverse drug reaction (ADRs).Research design and methods: We retrieved information from the US Food and Drug Administration Adverse Event Reporting System (FAERS) over a 13-year period. Reporting odds ratio (ROR) for MS was calculated for each single substance. Disproportionality signals were considered when at least 10 cases were retrieved with a lower limit of the 95% confidence interval (CI) >1.Results: After a customized data-mining process, 3,226 reports of MS were retrieved. ‘Antineoplastic and immunomodulating drugs’ (33% of total reports) were the most frequently reported, with 10 disproportionality signals, including etanercept (445 cases; ROR: 2.48; 95% Cl: 2.24–2.74), adalimumab (329; 2.05; 1.83–2.30), and infliximab (119; 2.25; 1.87–2.70). We also observed signals for drugs acting on hormone balance, bone density, and central nervous system.Conclusion: Our findings suggest that immunomodulatory drugs increase the risk of MS and point out that some other drug classes should be further investigated for this risk.

Published
2018
Full Text
View/download PDF

90. Dipeptidyl peptidase-4 inhibitors and heart failure: Analysis of spontaneous reports submitted to the FDA Adverse Event Reporting System.

Author

Raschi, E., Poluzzi, E., Koci, A., Antonazzo, I.C., Marchesini, G., and De Ponti, F.

Abstract

Background and Aims: We tested the possible association between dipeptidyl peptidase-4 inhibitors (DPP-4-I) use and heart failure (HF) occurrence by assessing the publicly available US-FDA Adverse Event Reporting System (FAERS).Methods: FAERS data reporting HF and DPP-4-Is use in the period from the fourth quarter of 2006 through 2013 were extracted, using the Standardized MedDRA Query "Cardiac failure". Disproportionality (case/non-case method) was implemented by calculating Reporting Odds Ratios (RORs) with 95% Confidence Interval (CI): (1) exploratory analysis on the entire FAERS (using rosiglitazone as positive control); (2) consolidated analyses by therapeutic area (within antidiabetics), correcting for event- and drug-related competition bias and adjusting for co-reported drugs as confounders.Results: HF during DPP4-I use was recorded in 390 reports (4.4% of total reports). In exploratory analysis, statistically significant ROR emerged for DPP-4-I as a class (ROR = 1.17; 95% CI = 1.05-1.29), saxagliptin (1.68; 1.29-2.17), vildagliptin (2.39; 1.38-4.14), and rosiglitazone (13.98; 13.30-14.70). In consolidated analyses, the ROR for saxagliptin (2.60; 1.92-3.50) and vildagliptin (4.07; 2.28-7.27) increased, and became also significant for sitagliptin (1.61; 1.40-1.86). Concomitant drugs were reported in more than 50% of cases; the adjusted RORs of saxagliptin (2.30; 1.70-3.10), vildagliptin (3.15; 1.76-5.63), and sitagliptin (1.48; 1.28-1.71) were nonetheless significant.Conclusion: FAERS data are consistent with clinical studies on a possible association between saxagliptin and HF. The disproportionate reporting of HF with sitagliptin, conflicting with a recent phase IV trial, suggests that cardiovascular safety requires close post-marketing vigilance by clinicians of individual DPP-4-I in the community until the issue of class effect is solved. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

91. Sex specific adaptations in placental biometry of overweight and obese women.

Author

Mandò, Chiara, Calabrese, Stefania, Mazzocco, Martina Ilaria, Novielli, Chiara, Anelli, Gaia Maria, Antonazzo, Patrizio, and Cetin, Irene

Subjects
FETAL physiology, PLACENTA physiology, PHYSIOLOGICAL adaptation, OBESITY, PLACENTA, PREGNANCY complications, SEX distribution, WEIGHT gain, FETAL development, CASE-control method
Abstract

Introduction: Placental biometry at birth has been shown to predict chronic disease in later life. We hypothesized that maternal overweight/obesity, a state of low-grade inflammation and risk factor for adverse pregnancy outcome, could negatively influence placental development and that differences would be sex-specific.Methods: 696 women (537 normal-weight, NW; 112 overweight, OW; 47 obese, OB) with singleton uncomplicated pregnancies were prospectively enrolled at term delivery. Gestational age, maternal (age, height, pre-pregnancy BMI, gestational weight gain -GWG, hemoglobin, hematocrit and glycemia), fetal (weight, length, ponderal index, cranial circumference) and placental (weight, diameters) data were collected. Placental area, thickness and efficiency (fetal/placental weight ratio, F/P) were calculated.Results: GWG was within standard recommendations in OB, while OW exceeded it. Placental weight was significantly higher in OW versus NW, but not in OB, leading to significantly higher placental thickness and lower F/P in this group. In the total population, a significant interaction effect between maternal BMI and fetal sex on placental weight and efficiency was found. Indeed, differences in placental parameters were present only in female offspring.Discussion: In our population of OW and OB uncomplicated pregnancies only OW women, presenting GWG over standard recommendations, had thicker and less efficient placentas. We also reported different placental adaptation depending on fetal sex, with significant changes only in female fetuses. This may be part of a female-specific strategy aiming to ensure survival if another adverse event occurs. Customized counseling according to maternal BMI and fetal sex should be evaluated in clinical care. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

93. Digestibility, toxicity and metabolic effects of rapeseed and sunflower protein hydrolysates in mice

Author

Canistro, Donatella, Vivarelli, Fabio, Ugolini, Luisa, Pinna, Carlo, Grandi, Monica, Antonazzo, Ippazio Cosimo, Cirillo, Silvia, Sapone, Andrea, Cinti, Susanna, Lazzeri, Luca, Conte, Emanuele, and Biagi, Giacomo

Abstract

AbstractThe digestibility (in vitro), toxicity and metabolic effects of rapeseed (RPH) and sunflower (SPH) protein hydrolysates have been evaluated in a murine animal model. The enzyme Alcalase®was employed to obtain a mild enzymatic hydrolysis of rapeseed and sunflower defatted seed meals (DSM) protein isolates. Both hydrolysates showed higher in vitrodigestibility than the respective DSM, presumably as a consequence of the hydrolysis process that they had undergone. In vivo, RPH and SPH were well tolerated. Body and organ weights, biochemical blood parameters from treated male mice were comparable to controls. Food intake was regular in RPH and SPH animals, suggesting a good palatability of the hydrolysates. Not relevant perturbations of the principal hepatic and renal drug metabolism enzymes were observed in RPH or SPH mice. In conclusion, protein hydrolysates from sunflower and rapeseed DSM did not determine relevant toxicological effects; therefore, they could be considered as alternative protein sources and/or food ingredients.

Published
2017
Full Text
View/download PDF

97. FlyBase at 25: looking to the future

Author

Gramates, L. Sian, Marygold, Steven J., dos Santos, Gilberto, Urbano, Jose-Maria, Antonazzo, Giulia, Matthews, Beverley B., Rey, Alix J., Tabone, Christopher J., Crosby, Madeline A., Emmert, David B., Falls, Kathleen, Goodman, Joshua L., Hu, Yanhui, Ponting, Laura, Schroeder, Andrew J., Strelets, Victor B., Thurmond, Jim, and Zhou, Pinglei

Abstract

Since 1992, FlyBase (flybase.org) has been an essential online resource for the Drosophila research community. Concentrating on the most extensively studied species, Drosophila melanogaster, FlyBase includes information on genes (molecular and genetic), transgenic constructs, phenotypes, genetic and physical interactions, and reagents such as stocks and cDNAs. Access to data is provided through a number of tools, reports, and bulk-data downloads. Looking to the future, FlyBase is expanding its focus to serve a broader scientific community. In this update, we describe new features, datasets, reagent collections, and data presentations that address this goal, including enhanced orthology data, Human Disease Model Reports, protein domain search and visualization, concise gene summaries, a portal for external resources, video tutorials and the FlyBase Community Advisory Group.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results