51. Pharmacological and computer-aided studies provide new insights into Millettia peguensis Ali (Fabaceae)
- Author
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Safaet Alam, Nazim Uddin Emon, Saimon Shahriar, Fahmida Tasnim Richi, Mohammad Rashedul Haque, Mohammad Nazmul Islam, Shahenur Alam Sakib, and Amlan Ganguly
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Millettia peguensis ,Analgesic ,Antidiarrheal ,Antioxidant ,Antitumor ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Millettia peguensis, popular for its ethnopharmacological uses, was employed to evaluate its different pharmacological properties in this study. The analgesic studies of the plant have been performed by acetic acid-induced writhing and formalin-induced licking tests respectively, whereas the antidiarrheal experiment was done by castor oil-induced diarrheal test. Besides, antioxidant, cytotoxic, antimicrobial, thrombolytic evaluations were performed by DPPH scavenging with phenol content determination, brine shrimp lethality, disc diffusion and clot lysis methods respectively. Moreover, in silico study of the phytoconstituents was carried out by molecular docking and ADME/T analysis.The methanol extract of Millettia peguensis (MEMP) revealed significant biological activity in the analgesic and antidiarrheal test (p
- Published
- 2020
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