1,140 results on '"Anthoney A"'
Search Results
52. An examination of development factors in the UK children's multimedia market
- Author
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Anthoney, Audrey McIntosh, Royle, Jo, and Johnson, Ian M.
- Subjects
338 - Abstract
The project topic developed in early 1998 as it emerged that there was a need for research into the area of children's multimedia in the UK. Research by others into the area of `generic' multimedia, products and technology, had been ongoing since the mid- I990s when the multimedia market started to develop rapidly. However, research focusing specifically on children's multimedia was lacking. Children's multimedia, which makes up a large share of the UK multimedia market, grew rapidly in the late 1990s as PCs, hardware, software and online use increased and related costs reduced in the UK. It was useful to study the children's multimedia market, as a leading edge example from the multimedia sector undergoing change, for publishing companies in other sectors learning how to develop their `businesses' for multimedia production. This sector was identified as an interesting, evolving and original area in which little was known about in terms of the market forces, consumer, company types involved, company activities and product features. The research analysed in depth the children's multimedia industry in the UK and the challenges and successes in adapting to change in this volatile market. Questionnaire surveys in 1998 and 1999 were used to obtain market and background information into the market situation and company activity (successful and otherwise). A Children's Multimedia Five Force model (developed from Porter's model (1980)) was designed to outline the key external forces affecting the strategic development of two company types, publishing and `new media companies' (companies set up in the 1990s for the purpose of producing solely multimedia), studied in the UK children's multimedia market. Interviews were undertaken in 1999 and 2000 with the successful companies identified in order to critically analyse both their internal and external activity and development. Internal activities, factors adding value, or contributing towards development which the companies studied either had or required, (in relation to product, structural, procedural, and strategic development) have been outlined in a Children's Multimedia Value Chain. This value chain was informed by elements of Porter's Value Chain model, and adapted versions of his original model by Vista International, and Diebold. This more detailed model has been developed with empirical evidence from a sample of successful children's multimedia companies. This seems to be the first study involving the development of models grounded in the reality of the developing and changing world of multimedia. The research also directly contributes towards projects and initiatives being encouraged by the European Commission and UK Government encouraging the growth and development of multimedia products and companies in the UK at the time of study. It also provides original insight into strategic change management in the publishing sector, and outlines analytical approaches which can be adapted or transferred to other publishing areas. The findings, particular to this children's multimedia market study, are intended to create interest in the model and to provide a starting point that can be further elaborated by researchers in other sectors of the publishing industry, or related areas such as the information, communications or `multimedia' industries. Other studies surveying the requirements of `children', `parents' or `educators' could potentially build on the findings of this research, which focused on the company and market situation. The modelling structures could also be developed or adapted to involve a more quantitative analytical approach - measuring costs, financial output and implications of multimedia production, which would develop this study which focuses on the core resources, skills, competencies and relationships within children's multimedia companies.
- Published
- 2003
53. A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer
- Author
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Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S. Walter, Sarah Blagden, Alan Anthoney, Barbara J. Klencke, Mark M. Kowalski, Udai Banerji, Institut Català de la Salut, [Jones R] Velindre School of Medicine, Cardiff University, and Velindre University NHS Trust, Cardiff, United Kingdom. [Plummer R] Newcastle University and Newcastle Hospitals NHS Trust, Newcastle Upon Tyne, United Kingdom. [Moreno V] START Madrid-Fundacion Jiménez Díaz, Fundación Jiménez Díaz University Hospital, Madrid, Spain. [Carter L] Division of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom. [Roda D] Biomedical Research Institute INCLIVA, Valencia, Spain. [Garralda E] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Neoplasms [DISEASES] ,neoplasias [ENFERMEDADES] ,Cancer Research ,Oncology ,Càncer - Tractament ,Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Medicaments antineoplàstics - Ús terapèutic ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] - Abstract
Gemcitabina; Cáncer avanzado Gemcitabina; Càncer avançat Gemcitabine; Advanced cancer Purpose: This was a Phase I/II trial of the novel checkpoint kinase 1 (Chk1) inhibitor SRA737 given in combination with gemcitabine. Its objectives were to establish the safety profile, recommended Phase 2 dose (RP2D), pharmacokinetics profile, and clinical activity of SRA737. Patients and Methods: Patients with advanced solid tumors were enrolled into dose-escalation cohorts and treated in 28-day cycles with oral SRA737 on days 2, 3, 9, 10, 16, and 17, and intravenous gemcitabine on days 1, 8, and 15. Treatment was continued until progression. Each expansion cohort included up to 20 patients with specific genetically defined tumors. Results: The RP2D was determined to be 500 mg SRA737 combined with low-dose (250 mg/m2) gemcitabine. Of 143 enrolled patients, 77 were treated at doses of at least 500 mg SRA737 combined with 250 mg/m2 gemcitabine. Common toxicities of nausea, vomiting, fatigue, and diarrhea were primarily mild to moderate, and rarely led to treatment discontinuation. Anemia, neutropenia, and thrombocytopenia were grade ≥3 in 11.7%, 16.7%, and 10% of patients treated at the RP2D, respectively. The objective response rate (ORR) was 10.8% overall and notably the ORR in anogenital cancer was 25%. Partial tumor responses were observed in anogenital cancer, cervical cancer, high-grade serous ovarian cancer, rectal cancer, and small cell lung cancer. Conclusions: SRA737 in combination with low-dose gemcitabine was well tolerated with lower myelotoxicity than has been seen at standard doses of gemcitabine or with other combinations of Chk1 inhibitors with gemcitabine. Tumor responses were observed in anogenital and other solid tumors. The trial was sponsored by Sierra Oncology, Inc. Medical writing support was provided by Tina Ippolito, an independent consultant funded by Sierra Oncology. Andrew Dye, an employee of Sierra Oncology, also provided medical writing support and data curation. Bryan Strouse, an employee of Sierra Oncology, also contributed to data curation for this report. UK clinical trial sites acknowledge infrastructural funding from the Experimental Cancer Medical Center and National Institute of Health and Care Research Biomedical Research Centers. The ICR/RMH in addition acknowledges Cancer Research UK funding to Cancer Centre Funding and funding to the Cancer Therapeutics Unit. U. Banerji is a recipient of the NIHR RP-2016–07–028. The publication costs of this article were defrayed in part by the payment of publication fees. Therefore, and solely to indicate this fact, this article is hereby marked “advertisement” in accordance with 18 USC section 1734.
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- 2022
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54. Attachment Styles and their Demographic Association Among Adult Children of Alcoholic Fathers in Pakistan
- Author
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Sarah Anthoney, Elizabeth Schwaiger Suneel, and Ivan Suneel
- Subjects
Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Professions (miscellaneous) - Abstract
Objectives: To study the relationship between demographics and attachment styles among adult children of alcoholic fathers. Study Design: Cross-sectional study. Place and Duration of Study: Private Rehabilitation Centers, Lahore Pakistan, from Jan to Apr 2020. Methodology: A sample of almost equal participation of both genders (202 males and 198 females) were included in the study. Two measuring tools were used, a Demographic questionnaire and the Adult Attachment questionnaire. Results: Chi-square test indicated that attachment style was significantly associated with age [p < 0.001], education [p < 0.001], and birth order [p < 0.001], However, gender [p =0.374] and number of siblings [p=0.876] were not significantly associated. Conclusion: There is a relationship between attachment styles and associated demographics of adult children of alcoholic fathers. Based on these findings, the alcoholics and their families could be educated, an intervention plan could be developed, and literature could educate the masses about alcoholism and its impact on children.
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- 2022
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55. Effects of Air Gaps on Heat Loss through Firefighter Turnout Composites with Different Moisture Barrier Components
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Huipu Gao, Anthoney Shawn Deaton, Roger Barker, Emiel DenHartog, and Xiaomeng Fang
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Polymers and Plastics ,General Chemical Engineering ,General Chemistry - Published
- 2022
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56. SPECTROPHOTOMETRIC DETERMINATION OF IRON CONTENT IN SIX INDIGENOUS GREEN LEAFY VEGETABLES CONSUMED IN MUAK LEK, THAILAND
- Author
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Anthoney Swamy Thangiah, Aldrich Titus Anthoney, and Wilai Laolee
- Subjects
General Energy ,General Chemical Engineering ,General Chemistry ,General Pharmacology, Toxicology and Pharmaceutics ,Biochemistry - Abstract
This study was undertaken to determine the iron and moisture content of six popular green leafy vegetables (GLV) consumed in Muak Lek, Thailand. The six different green leafy vegetables were Holy basil (Bai Kaprow), Sweet basil (Bai horapa), Amaranthus spinosus (Pak khoum), Lettuce (Pak Salad), Chinese kale (Pak khana), Coccinia (Pak tumlun). The spectrophotometric method was used to determine the concentration of iron from uncooked (raw), cooked, and their pot liquor at 480 nm. Among these green leafy vegetables, the pot liquor of Coccinia (21.41 ppm) had the highest iron content, whereas the least concentration was found in cooked Lettuce (0.235 ppm). Besides, raw Lettuce showed the highest moisture content of 94.74%, and raw Amaranthus appeared to have the least moisture content, 66.18%. All the investigated GLV samples contain iron; however, there were variations among the uncooked, cooked, and pot liquor. Moreover, the GLV pot liquor had a higher concentration of iron than cooked and uncooked (raw) green leafy vegetables. Therefore, cooked GLV with its pot liquor consumption would be the best option to obtain large iron quantities.
- Published
- 2022
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57. Circulating biomarkers during treatment in patients with advanced biliary tract cancer receiving cediranib in the UK ABC-03 trial
- Author
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Backen, Alison C., Lopes, Andre, Wasan, Harpreet, Palmer, Daniel H, Duggan, Marian, Cunningham, David, Anthoney, Alan, Corrie, Pippa G., Madhusudan, Srinivasan, Maraveyas, Anthony, Ross, Paul J., Waters, Justin S., Steward, William P., Rees, Charlotte, McNamara, Mairéad G., Beare, Sandy, Bridgewater, John A., Dive, Caroline, and Valle, Juan W.
- Published
- 2018
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58. Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy
- Author
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Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., Campbell, F., Costello, E., Halloran, C. M., Mackey, J. R., Scarfe, A. G., Valle, J. W., McDonald, A. C., Carter, R., Tebbutt, N. C., Goldstein, D., Shannon, J., Dervenis, C., Glimelius, B., Deakin, M., Charnley, R. M., Anthoney, A., Lerch, M. M., Mayerle, J., Oláh, A., Büchler, M. W., Greenhalf, W., and for the European Study Group for Pancreatic Cancer
- Published
- 2018
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59. Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer
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Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., Campbell, F., Costello, E., Halloran, C. M., Mackey, J. R., Scarfe, A. G, Valle, J. W., McDonald, A. C., Carter, R., Tebbutt, N. C., Goldstein, D., Shannon, J., Dervenis, C., Glimelius, B., Deakin, M., Charnley, R. M., Anthoney, Alan, Lerch, M. M., Mayerle, J., Oláh, A., Büchler, M. W., Greenhalf, W., and for the European Study Group for Pancreatic Cancer
- Published
- 2018
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60. Making connections and building resilience: Developing workshops with undergraduates
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Julia Anthoney, Rachel Stead, and Katie Turney
- Subjects
General Works - Abstract
While defining resilience is recognised as complex with recent research highlighting the disparity of interpretations, there is however, a common appreciation of the wide range of contributory factors impacting on students’ resilience within the Higher Education sector. These can include but are not limited to, an increasingly competitive environment for graduate jobs, increased financial pressure from student tuition fees, alongside the more traditional concerns of moving away from home and transitioning towards greater independence. Building on previous research at the University of Surrey with high achieving students, this paper outlines the development and delivery of a student focused workshop designed to enable the participants to build their understanding of resilience using different but complementary pedagogic approaches: LEGO® SERIOUS PLAY® and Concept Mapping. The case study included within this paper demonstrates one student’s reflection of the workshop and previous experiences which have contributed to their own resilience. What has become apparent at the University of Surrey, and more broadly within the UK Higher Education sector, is that universities have a vital role to play in fostering positive mindsets amongst students and developing strong and resilient independent learners.
- Published
- 2017
61. Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila
- Author
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Anthoney, Niki, primary, Tainton-Heap, Lucy A.L., additional, Luong, Hang, additional, Notaras, Eleni, additional, Zhao, Qiongyi, additional, Perry, Trent, additional, Batterham, Philip, additional, Shaw, Paul J., additional, and van Swinderen, Bruno, additional
- Published
- 2023
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62. Testicular salvageability and its predictors among patients with testicular torsion in a resource limited setting; a multicentre longitudinal study
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Mohamed, Mohamed Abdullahi, primary, Abraha, Demoz, additional, Olasinde, Anthoney Ayotunde, additional, Kiswezi, Ahmed, additional, Molen, Selamo Fabrice, additional, Muhumuza, Joshua, additional, and Lule, Herman, additional
- Published
- 2023
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63. Oncocytic Adrenocortical Carcinoma - a rare variant
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Poe, Poe Han Htwe Nang, primary, Abbas, Afroze, additional, Fraser, Sheila, additional, and Anthoney, Alan, additional
- Published
- 2023
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64. Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary
- Published
- 2023
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65. Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary
- Published
- 2023
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66. Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
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Samson, Adel, primary, West, Emma J., primary, Carmichael, Jonathan, primary, Scott, Karen J., primary, Turnbull, Samantha, primary, Kuszlewicz, Bethany, primary, Dave, Rajiv V., primary, Peckham-Cooper, Adam, primary, Tidswell, Emma, primary, Kingston, Jennifer, primary, Johnpulle, Michelle, primary, da Silva, Barbara, primary, Jennings, Victoria A., primary, Bendjama, Kaidre, primary, Stojkowitz, Nicolas, primary, Lusky, Monika, primary, Prasad, K.R., primary, Toogood, Giles J., primary, Auer, Rebecca, primary, Bell, John, primary, Twelves, Chris J., primary, Harrington, Kevin J., primary, Vile, Richard G., primary, Pandha, Hardev, primary, Errington-Mais, Fiona, primary, Ralph, Christy, primary, Newton, Darren J., primary, Anthoney, Alan, primary, Melcher, Alan A., primary, and Collinson, Fiona, primary
- Published
- 2023
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67. Experimentally induced active and quiet sleep engage non-overlapping transcriptomes inDrosophila
- Author
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Anthoney, Niki, primary, Tainton-Heap, Lucy A.L., additional, Luong, Hang, additional, Notaras, Eleni, additional, Zhao, Qiongyi, additional, Perry, Trent, additional, Batterham, Philip, additional, Shaw, Paul J., additional, and van Swinderen, Bruno, additional
- Published
- 2023
- Full Text
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68. A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours
- Author
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Jamieson, David, Griffin, Melanie J., Sludden, Julieann, Drew, Yvette, Cresti, Nicola, Swales, Karen, Merriman, Mark, Allen, Rodger, Bevan, Paul, Buerkle, Markus, Mala, Carola, Coyle, Vicky, Rodgers, Lisa, Dean, Emma, Greystoke, Alastair, Banerji, Udai, Wilson, Richard H., Evans, T.R. Jeffery, Anthoney, Alan, Ranson, Malcolm, Boddy, Alan V., and Plummer, Ruth
- Published
- 2016
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69. Defective mismatch repair and cisplatin resistance in ovarian cancer cells
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Anthoney, David Alan
- Subjects
572.8 ,Drug resistance ,Tumour cells ,DNA repair - Abstract
The development of resistance to anticancer drugs poses one of the major obstacles to improving the survival from malignant disease. Most clinically effective anticancer agents act upon DNA. Resistance has been shown to arise by mechanisms that reduce the amount of drug reaching the DNA. However, drug resistance developing through alterations in the capacity of tumour cells to repair or respond to DNA damage, may be as important. Microsatellite instability (RER+) is generally taken as an indication of defective DNA mismatch repair. Ovarian and breast carcinoma cell lines, selected for resistance to cisplatin and doxorubicin, were shown to display an RER+ phenotype as shown by multiple mutations at microsatellite loci in comparison to the parental line. The ovarian carcinoma cell line A2780 was shown to be RER- by microsatellite analysis of random sub-clones from the cell line. A2780/cp70, a cisplatin resistant cell line derived from A2780, displayed an RER+ phenotype when subject to the same analysis. Ten independently derived, cisplatin resistant, A2780 cell lines were developed by selection with increasing concentrations of cisplatin to a final concentration of 15muM. These were shown to display stable resistance to cisplatin of between 4 fold (as determined by clonogenic assay) and 7 fold (s determined by MTT assay), when compared to the parental line. The RER+ phenotype was detected in all but one of these lines. An association between the RER+ phenotype and cisplatin resistance was further strengthened by the finding of microsatellite instability in resistant A2780 cell lines selected by a single exposure to 15muM cisplatin. Mutations in genes involved in mismatch repair have been shown to be responsible for microsatellite instability. The biochemical basis of the RER+ phenotype in drug resistant A2780 derived cell lines was determined by in vitro repair assay. An inability to correct DNA mismatches, when repair was directed from 3' to the lesion, was observed, and hMutLalpha was identified as the defective component of mismatch repair by in vitro complementation. Further studies revealed the absence of hMLH1 and hPMS2 proteins, which constitute hMutLalpha, within the RER+ resistant cell lines. This arises from the failure of these cells to express hMLH1 mRNA. No defect in the expression of the other known mismatch repair genes was observed. P53-dependent DNA damage responses were characterised in the RER+, drug resistant cell lines. A correlation was observed between RER+ status and loss of radiation induced G1 arrest, reduced expression of the CIP 1 gene and decreased levels of apoptosis after cisplatin exposure. This association between DNA mismatch repair and the DNA damage response pathway suggests that the mismatch repair system might act as a sensor for DNA damage. This supports the hypothesis that mismatch repair may be involved in determining the cellular sensitivity to cisplatin; defects in such repair leading to cisplatin resistance.
- Published
- 1997
70. Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, and Adel Samson
- Abstract
Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Published
- 2023
- Full Text
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71. Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, and Adel Samson
- Abstract
Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Published
- 2023
- Full Text
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72. Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, and Adel Samson
- Abstract
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic virus that has reached late-phase clinical trials. We report the results of a single-center, nonrandomized biological end point study (trial registration: EudraCT number 2012-000704-15), which builds on the success of the presurgical intravenous delivery of oncolytic viruses to tumors. Nine patients with either colorectal cancer liver metastases or metastatic melanoma were treated with a single intravenous infusion of Pexa-Vec ahead of planned surgical resection of the metastases. Grade 3 and 4 Pexa-Vec–associated side effects were lymphopaenia and neutropaenia. Pexa-Vec was peripherally carried in plasma and was not associated with peripheral blood mononuclear cells. Upon surgical resection, Pexa-Vec was found in the majority of analyzed tumors. Pexa-Vec therapy associated with IFNα secretion, chemokine induction, and resulted in transient innate and long-lived adaptive anticancer immunity. In the 2 patients with significant and complete tumor necrosis, a reduction in the peripheral T-cell receptor diversity was observed at the time of surgery. These results support the development of presurgical oncolytic vaccinia virus-based therapies to stimulate anticancer immunity and increase the chances to cure patients with cancer.
- Published
- 2023
- Full Text
- View/download PDF
73. Experimentally induced active and quiet sleep engage non-overlapping transcriptomes inDrosophila
- Author
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Niki Anthoney, Lucy A.L. Tainton-Heap, Hang Luong, Eleni Notaras, Qiongyi Zhao, Trent Perry, Philip Batterham, Paul J. Shaw, and Bruno van Swinderen
- Abstract
Sleep in mammals is broadly classified into two different categories: rapid eye movement (REM) sleep and slow wave sleep (SWS), and accordingly REM and SWS are thought to achieve a different set of functions. The fruit flyDrosophila melanogasteris increasingly being used as a model to understand sleep functions, although it remains unclear if the fly brain also engages in different kinds of sleep as well. Here, we compare two commonly used approaches for studying sleep experimentally inDrosophila: optogenetic activation of sleep-promoting neurons and provision of a sleep-promoting drug, Gaboxadol. We find that these different sleep-induction methods have similar effects on increasing sleep duration, but divergent effects on brain activity. Transcriptomic analysis reveals that drug-induced deep sleep (‘quiet’ sleep) mostly downregulates metabolism genes, whereas optogenetic ‘active’ sleep upregulates a wide range of genes relevant to normal waking functions. This suggests that optogenetics and pharmacological induction of sleep inDrosophilapromote different features of sleep, which engage different sets of genes to achieve their respective functions.
- Published
- 2023
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74. The Relationship between Soil Chemistry and the Occurrence of Echinacea laevigata in Northeast Georgia
- Author
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Menzel, Timothy O., Willsea, Anthoney W., and Dooley, Debra
- Published
- 2016
75. Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
- Author
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Adel Samson, Emma J. West, Jonathan Carmichael, Karen J. Scott, Samantha Turnbull, Bethany Kuszlewicz, Rajiv V. Dave, Adam Peckham-Cooper, Emma Tidswell, Jennifer Kingston, Michelle Johnpulle, Barbara da Silva, Victoria A. Jennings, Kaidre Bendjama, Nicolas Stojkowitz, Monika Lusky, K.R. Prasad, Giles J. Toogood, Rebecca Auer, John Bell, Chris J. Twelves, Kevin J. Harrington, Richard G. Vile, Hardev Pandha, Fiona Errington-Mais, Christy Ralph, Darren J. Newton, Alan Anthoney, Alan A. Melcher, and Fiona Collinson
- Subjects
Oncolytic Virotherapy ,Oncolytic Viruses ,Cancer Research ,Liver Neoplasms ,Immunology ,Leukocytes, Mononuclear ,Humans ,Vaccinia virus ,Neoadjuvant Therapy - Abstract
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic virus that has reached late-phase clinical trials. We report the results of a single-center, nonrandomized biological end point study (trial registration: EudraCT number 2012-000704-15), which builds on the success of the presurgical intravenous delivery of oncolytic viruses to tumors. Nine patients with either colorectal cancer liver metastases or metastatic melanoma were treated with a single intravenous infusion of Pexa-Vec ahead of planned surgical resection of the metastases. Grade 3 and 4 Pexa-Vec–associated side effects were lymphopaenia and neutropaenia. Pexa-Vec was peripherally carried in plasma and was not associated with peripheral blood mononuclear cells. Upon surgical resection, Pexa-Vec was found in the majority of analyzed tumors. Pexa-Vec therapy associated with IFNα secretion, chemokine induction, and resulted in transient innate and long-lived adaptive anticancer immunity. In the 2 patients with significant and complete tumor necrosis, a reduction in the peripheral T-cell receptor diversity was observed at the time of surgery. These results support the development of presurgical oncolytic vaccinia virus-based therapies to stimulate anticancer immunity and increase the chances to cure patients with cancer.
- Published
- 2022
- Full Text
- View/download PDF
76. High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults
- Author
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Traustadóttir, Tinna, Stock, Anthoney, and Harman, S.
- Abstract
Abstract: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are lipid-lowering agents widely employed for atherosclerosis prevention. HMG-CoA reductase blockade reduces skeletal muscle coenzyme Q
10 (CoQ10 ) levels and mitochondrial respiratory chain activities and may produce mild to severe skeletal muscle myopathy. This study investigated whether high-dose statin treatment would result in measurably decreased exercise capacity in older men and women. Maximal oxygen consumption, aerobic endurance, oxygen uptake kinetics, maximal strength, muscular power, and muscular endurance were measured before and after 12 weeks of statin treatment (simvastatin, 80 mg/day) in nine men and one woman, ages 55–76 years, with LDL-cholesterol levels >3.3 mmol/l (mean = 4.2 ± 0.2 mmol/l). Myalgia symptoms were assessed every 4 weeks. As expected, statin treatment resulted in significant decreases in LDL- and total-cholesterol levels (P < 0.01) with no significant changes in HDL-cholesterol or triglyceride levels. No significant changes were observed in aerobic capacity, endurance, oxygen kinetics or any measures of muscle function. No subject reported symptoms of myalgia, cramps, or weakness during the study. In the absence of myalgia or myopathic symptoms, high-dose simvastatin treatment did not impair exercise capacity in hyperlipidemic older individuals. We conclude that decreases in intramuscular CoQ10 , in most patients on high dose statin treatment may not be clinically relevant, due to inter-individual variability in the degree of CoQ10 depletion, sensitivity of muscle to decreases in CoQ10 , or both.- Published
- 2024
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77. Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade
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Samson, Adel, Scott, Karen J., Taggart, David, West, Emma J., Wilson, Erica, Nuovo, Gerard J., Thomson, Simon, Corns, Robert, Mathew, Ryan K., Fuller, Martin J., Kottke, Timothy J., Thompson, Jill M., Ilett, Elizabeth J., Cockle, Julia V., van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S., Turnbull, Samantha J., Appleton, Elizabeth S., Migneco, Gemma, Rose, Ailsa S., Coffey, Matthew C., Beirne, Deborah A., Collinson, Fiona J., Ralph, Christy, Alan Anthoney, D., Twelves, Christopher J., Furness, Andrew J., Quezada, Sergio A., Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J., Selby, Peter J., Vile, Richard G., Griffin, Stephen D., Stead, Lucy F., Short, Susan C., and Melcher, Alan A.
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- 2018
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78. Vitamin D status of White pregnant women and infants at birth and 4 months in North West England: A cohort study
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Emmerson, Anthoney J. B., Dockery, Karen Elizabeth, Mughal, M. Z., Roberts, Stephen A., Tower, Clare Louise, and Berry, Jacqueline L.
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- 2018
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79. Resurgence of Vaccine-Preventable Disease: Ethics in the Pediatric Emergency Department
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Dreisinger, Naomi and Lim, Czer Anthoney
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- 2019
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80. The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development
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Connolly, Kyle J., O’Hare, Megan B., Mohammed, Alamin, Aitchison, Katelyn M., Anthoney, Niki C., Taylor, Matthew J., Stewart, Bryan A., Tuxworth, Richard I., and Tear, Guy
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- 2019
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81. Supplementary Data from Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma
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Middleton, Mark R., primary, McAlpine, Cheryl, primary, Woodcock, Victoria K., primary, Corrie, Pippa, primary, Infante, Jeffrey R., primary, Steven, Neil M., primary, Evans, Thomas R. Jeffry, primary, Anthoney, Alan, primary, Shoushtari, Alexander N., primary, Hamid, Omid, primary, Gupta, Avinash, primary, Vardeu, Antonella, primary, Leach, Emma, primary, Naidoo, Revashnee, primary, Stanhope, Sarah, primary, Lewis, Sion, primary, Hurst, Jacob, primary, O’Kelly, Ita, primary, and Sznol, Mario, primary
- Published
- 2023
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82. Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
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McCann, Katy J., primary, Mander, Ann, primary, Cazaly, Angelica, primary, Chudley, Lindsey, primary, Stasakova, Jana, primary, Thirdborough, Stephen M., primary, King, Andrew, primary, Lloyd-Evans, Paul, primary, Buxton, Emily, primary, Edwards, Ceri, primary, Halford, Sarah, primary, Bateman, Andrew, primary, O'Callaghan, Ann, primary, Clive, Sally, primary, Anthoney, Alan, primary, Jodrell, Duncan I., primary, Weinschenk, Toni, primary, Simon, Petra, primary, Sahin, Ugur, primary, Thomas, Gareth J., primary, Stevenson, Freda K., primary, and Ottensmeier, Christian H., primary
- Published
- 2023
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83. Supplementary Tables S1-S5 from Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
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Albertella, Mark R., primary, Loadman, Paul M., primary, Jones, Philip H., primary, Phillips, Roger M., primary, Rampling, Roy, primary, Burnet, Neil, primary, Alcock, Chris, primary, Anthoney, Alan, primary, Vjaters, Egils, primary, Dunk, Chris R., primary, Harris, Peter A., primary, Wong, Alvin, primary, Lalani, Alshad S., primary, and Twelves, Chris J., primary
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- 2023
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84. Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
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McCann, Katy J., primary, Mander, Ann, primary, Cazaly, Angelica, primary, Chudley, Lindsey, primary, Stasakova, Jana, primary, Thirdborough, Stephen M., primary, King, Andrew, primary, Lloyd-Evans, Paul, primary, Buxton, Emily, primary, Edwards, Ceri, primary, Halford, Sarah, primary, Bateman, Andrew, primary, O'Callaghan, Ann, primary, Clive, Sally, primary, Anthoney, Alan, primary, Jodrell, Duncan I., primary, Weinschenk, Toni, primary, Simon, Petra, primary, Sahin, Ugur, primary, Thomas, Gareth J., primary, Stevenson, Freda K., primary, and Ottensmeier, Christian H., primary
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- 2023
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85. Switch-like Compaction of Poly(ADP-ribose) Upon Cation Binding
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Badiee, Mohsen, primary, Kenet, Adam L, additional, Ganser, Laura R, additional, Paul, Tapas, additional, Myong, Sua, additional, and Leung, Anthoney KL, additional
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- 2023
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86. Emergency Department-based monoclonal antibody therapy for patients with mild to moderate COVID-19
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Devlin, Amanda, primary, O'Neill, Ann, additional, Anthoney, C., additional, Lim, E., additional, Simms, Charmaine, additional, Eiting, Erick, additional, Nunez, Jeranil, additional, Farraj, Rowaida, additional, Koshy, Sanjana, additional, and Calderon, Yvette, additional
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- 2023
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87. NET-02 final results: A randomised, phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line (2L) therapy in patients (pts) with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (PD-EP-NEC).
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McNamara, Mairead Geraldine, primary, Swain, Jayne, additional, Craig, Zoe, additional, Sharma, Rohini, additional, Faluyi, Olusola Olusesan, additional, Wadsley, Jonathan, additional, Morgan, Carys, additional, Wall, Lucy R., additional, Chau, Ian, additional, Reed, Nick, additional, Sarker, Debashis, additional, Margetts, Jane, additional, Krell, Daniel, additional, Cave, Judith, additional, Sharmila, Sothi, additional, Anthoney, Alan, additional, Patel, Alkesh, additional, Lamarca, Angela, additional, Hubner, Richard, additional, and Valle, Juan W., additional
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- 2023
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88. Guardianship, Its Importance and Developments: A Comparative Study Between Shariah Law and the Positive Law
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Olayemi, Abdul Azeez Maruf, primary and Olagunju, Anthoney Gbadebo, additional
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- 2023
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89. Histological evaluation of wound healing by topical phenytoin application on extraction socket: an in vivo study in albino Wistar rats
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Christopher, Maruf, primary, Fazal, Amber, additional, Mehdi, Muhammad Mutahir, additional, Anthoney, Daud, additional, Idrees, Qura-Tul-Ain, additional, and Javaid, Rashid, additional
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- 2023
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90. Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial
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Valle, Juan W, Wasan, Harpreet, Lopes, Andre, Backen, Alison C, Palmer, Daniel H, Morris, Karen, Duggan, Marian, Cunningham, David, Anthoney, D Alan, Corrie, Pippa, Madhusudan, Srinivasan, Maraveyas, Anthony, Ross, Paul J, Waters, Justin S, Steward, Will P, Rees, Charlotte, Beare, Sandy, Dive, Caroline, and Bridgewater, John A
- Published
- 2015
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91. Data from First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
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Udai Banerji, James Spicer, Chris Twelves, Keith Jones, Jenny Prince, Michiyasu Inatani, Rie Shiokawa, Kohei Noguchi, Lorna Pope, Ruth Riisnaes, Karen Swales, Shaun Decordova, Alan Anthoney, David J. Pinato, Andrea Zivi, Chara Stavraka, Debra Josephs, Aurelius Olmin, and Sarah Blagden
- Abstract
Purpose: This phase I dose-escalation study investigated the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of CH5132799.Experimental Design: Patients with metastatic solid tumors were eligible for the study. CH5132799 was administered orally once daily or twice daily in 28-day cycles.Results: Thirty-eight patients with solid tumors received CH5132799 at 2 to 96 mg once daily or 48 to 72 mg twice daily. The MTD was 48 mg on the twice-daily schedule but was not reached on the once daily schedule. DLTs were grade 3 elevated liver function tests (LFT), grade 3 fatigue, grade 3 encephalopathy, grade 3 diarrhea, and grade 3 diarrhea with grade 3 stomatitis; all DLTs were reversible. Most drug-related adverse events were grade 1/2. Diarrhea (34%) and nausea (32%) were the most common events. Mean Cmax and AUC0-24 in steady state at MTD were 175 ng/mL and 1,550 ng·h/mL, respectively, consistent with efficacious exposure based on preclinical modeling. Reduction in SUVmax with [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) was observed in 5 of 7 patients at MTD. A patient with PIK3CA-mutated clear cell carcinoma of the ovary achieved a partial response by GCIG CA125 criteria and further, a heavily pretreated patient with triple-negative breast cancer had marked improvement in her cutaneous skin lesions lasting six cycles.Conclusion: CH5132799 is well tolerated at the MTD dose of 48 mg twice daily. At this dose, the drug had a favorable PK and PD profile and preliminary evidence of clinical activity. Clin Cancer Res; 20(23); 5908–17. ©2014 AACR.
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- 2023
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92. Supplementary Data from Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma
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Mario Sznol, Ita O’Kelly, Jacob Hurst, Sion Lewis, Sarah Stanhope, Revashnee Naidoo, Emma Leach, Antonella Vardeu, Avinash Gupta, Omid Hamid, Alexander N. Shoushtari, Alan Anthoney, Thomas R. Jeffry Evans, Neil M. Steven, Jeffrey R. Infante, Pippa Corrie, Victoria K. Woodcock, Cheryl McAlpine, and Mark R. Middleton
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Supplementary material
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- 2023
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93. Supplementary Data from First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
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Udai Banerji, James Spicer, Chris Twelves, Keith Jones, Jenny Prince, Michiyasu Inatani, Rie Shiokawa, Kohei Noguchi, Lorna Pope, Ruth Riisnaes, Karen Swales, Shaun Decordova, Alan Anthoney, David J. Pinato, Andrea Zivi, Chara Stavraka, Debra Josephs, Aurelius Olmin, and Sarah Blagden
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Supplementary Data. Inclusion and exclusion criteria
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- 2023
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94. Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
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Christian H. Ottensmeier, Freda K. Stevenson, Gareth J. Thomas, Ugur Sahin, Petra Simon, Toni Weinschenk, Duncan I. Jodrell, Alan Anthoney, Sally Clive, Ann O'Callaghan, Andrew Bateman, Sarah Halford, Ceri Edwards, Emily Buxton, Paul Lloyd-Evans, Andrew King, Stephen M. Thirdborough, Jana Stasakova, Lindsey Chudley, Angelica Cazaly, Ann Mander, and Katy J. McCann
- Abstract
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin.Experimental Design: Twenty-seven patients with CEA-expressing carcinomas were recruited: 15 patients with measurable disease (arm-I) and 12 patients without radiological evidence of disease (arm-II). Six intramuscular vaccinations of naked DNA (1 mg/dose) were administered up to week 12. Clinical and immunologic follow-up was up to week 64 or clinical/radiological disease.Results: DOM-specific immune responses demonstrated successful vaccine delivery. All patients without measurable disease compared with 60% with advanced disease responded immunologically, while 58% and 20% expanded anti-CAP-1 CD8+ T cells, respectively. CAP-1–specific T cells were only detectable in the blood postvaccination but could also be identified in previously resected cancer tissue. The gastrointestinal adverse event diarrhea was reported by 48% of patients and linked to more frequent decreases in CEA (P < 0.001) and improved global immunologic responses [anti-DOM responses of greater magnitude (P < 0.001), frequency (P = 0.004), and duration] compared with patients without diarrhea. In advanced disease patients, decreases in CEA were associated with better overall survival (HR = 0.14, P = 0.017). CAP-1 peptide was detectable on MHC class I of normal bowel mucosa and primary colorectal cancer tissue by mass spectrometry, offering a mechanistic explanation for diarrhea through CD8+ T-cell attack.Conclusions: Our data suggest that DNA vaccination is able to overcome peripheral tolerance in normal and tumor tissue and warrants testing in combination studies, for example, by vaccinating in parallel to treatment with an anti-PD1 antibody. Clin Cancer Res; 22(19); 4827–36. ©2016 AACR.
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- 2023
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95. Data from Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
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Chris J. Twelves, Alshad S. Lalani, Alvin Wong, Peter A. Harris, Chris R. Dunk, Egils Vjaters, Alan Anthoney, Chris Alcock, Neil Burnet, Roy Rampling, Roger M. Phillips, Philip H. Jones, Paul M. Loadman, and Mark R. Albertella
- Abstract
Purpose: AQ4N is a novel bioreductive prodrug under clinical investigation. Preclinical evidence shows that AQ4N penetrates deeply within tumors and undergoes selective activation to form AQ4, a potent topoisomerase II inhibitor, in hypoxic regions of solid tumors. This proof-of-principle, phase I study evaluated the activation, hypoxic selectivity, and safety of AQ4N in patients with advanced solid tumors.Experimental Design: Thirty-two patients with cancer (8 glioblastoma, 9 bladder, 8 head and neck, 6 breast, and 1 cervix) received a single 200 mg/m2 dose of AQ4N before elective surgery. AQ4 and AQ4N levels in 95 tissues (tumor, healthy tissue) were assessed by liquid chromatography-tandem mass spectrometry. Tissue sections were also analyzed for AQ4 fluorescence using confocal microscopy, and for expression of the hypoxia-regulated glucose transporter, Glut-1.Results: Activated AQ4 was detected in all tumor samples with highest levels present in glioblastoma (mean 1.2 μg/g) and head and neck (mean 0.65 μg/g) tumors; 22 of 32 patients had tumor AQ4 concentrations ≥0.2 μg/g, levels previously shown to be active in preclinical studies. In 24 of 30 tumor samples, AQ4 was detected at higher concentrations than in adjacent normal tissue (tumor to normal ratio range 1.1-63.6); distant skin samples contained very low concentrations of AQ4 (mean 0.037 μg/g). Microscopic evaluation of tumor sections revealed that AQ4 colocalized within regions of Glut-1+ hypoxic cells.Conclusions: AQ4N was activated selectively in hypoxic regions in human solid tumors. Intratumoral concentrations of AQ4 exceeded those required for activity in animal models and support the evaluation of AQ4N as a novel tumor-targeting agent in future clinical studies.
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- 2023
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96. Data from Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma
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Mario Sznol, Ita O’Kelly, Jacob Hurst, Sion Lewis, Sarah Stanhope, Revashnee Naidoo, Emma Leach, Antonella Vardeu, Avinash Gupta, Omid Hamid, Alexander N. Shoushtari, Alan Anthoney, Thomas R. Jeffry Evans, Neil M. Steven, Jeffrey R. Infante, Pippa Corrie, Victoria K. Woodcock, Cheryl McAlpine, and Mark R. Middleton
- Abstract
Purpose:Tebentafusp is a first-in-class bispecific fusion protein designed to target gp100 (a melanoma-associated antigen) through a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain, which redirects T cells to kill gp100-expressing tumor cells. Here, we report a multicenter phase I/II trial of tebentafusp in metastatic melanoma (NCT01211262) focusing on the mechanism of action of tebentafusp.Patients and Methods:Eighty-four patients with advanced melanoma received tebentafusp. Treatment efficacy, treatment-related adverse events, and biomarker assessments were performed for blood-derived and tumor biopsy samples obtained at baseline and on-treatment.Results:Tebentafusp was generally well-tolerated and active in both patients with metastatic uveal melanoma and patients with metastatic cutaneous melanoma. A 1-year overall survival rate of 65% was achieved for both patient cohorts. On-treatment cytokine measurements were consistent with the induction of IFNγ pathway–related markers in the periphery and tumor. Notably, tebentafusp induced an increase in serum CXCL10 (a T-cell attractant) and a reduction in circulating CXCR3+ CD8+ T cells together with an increase in cytotoxic T cells in the tumor microenvironment. Furthermore, increased serum CXCL10 or the appearance of rash (likely due to cytotoxic T cells targeting gp100-expressing skin melanocytes) showed a positive association with patient survival.Conclusions:These data suggest that redirecting T cells using a gp100-targeting TCR/anti-CD3 bispecific fusion protein may provide benefit to patients with metastatic melanoma. Furthermore, the activity observed in these two molecularly disparate melanoma classes hints at the broad therapeutic potential of tebentafusp.
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- 2023
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97. Supplementary Tables S1-S5 from Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
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Chris J. Twelves, Alshad S. Lalani, Alvin Wong, Peter A. Harris, Chris R. Dunk, Egils Vjaters, Alan Anthoney, Chris Alcock, Neil Burnet, Roy Rampling, Roger M. Phillips, Philip H. Jones, Paul M. Loadman, and Mark R. Albertella
- Abstract
Supplementary Tables S1-S5 from Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
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- 2023
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98. Predicting Delayed Shock in Multisystem Inflammatory Disease in Children
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Deborah A. Levine, Vincent Uy, William Krief, Cara Bornstein, Dina Daswani, Darshan Patel, Marni Kriegel, Nazreen Jamal, Kavita Patel, Tian Liang, Alexander Arroyo, Christopher Strother, Czer Anthoney Lim, Melissa L. Langhan, Ameer Hassoun, Haamid Chamdawala, Carl Philip Kaplan, Muhammad Waseem, Ee Tein Tay, David Mortel, Adam B. Sivitz, Christopher Kelly, Horton James Lee, Yuqing Qiu, Mark Gorelick, Shari L. Platt, and Peter Dayan
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Pediatrics, Perinatology and Child Health ,Emergency Medicine ,General Medicine - Published
- 2023
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99. Pancreaticobiliary Malignancies in the Emergency Room: Management of Acute Complications and Oncological Emergencies
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Konstantinos Kamposioras, Mohammed Dawod, Alan Anthoney, Jordan Appleyard, Joe Geraghty, Angela Lamarca, and Konstantinos Papadimitriou
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Gastrointestinal bleeding ,medicine.medical_specialty ,business.industry ,Gastroenterology ,Psychological intervention ,Medical Oncology ,Prognosis ,medicine.disease ,Clinical knowledge ,Increased risk ,Oncology ,Neoplasms ,Pancreatic cancer ,Ascites ,medicine ,Humans ,Human medicine ,Emergencies ,medicine.symptom ,Emergency Service, Hospital ,business ,Complication ,Intensive care medicine - Abstract
Background Management of pancreaticobiliary (PB) malignancies remains a clinical challenge. In this review, we focus on the management of oncological emergencies in PB malignancies and the potential complication of associated therapeutic interventions. Methods Biobliographic review of current evidence on the management of oncological emergencies, their potential complications, as well as synthesis of recommendations was performed. The pathogenesis, frequency, related symptoms as well as appropriate investigations are presented. Results The oncologic emergencies in PB patients were summarised in six categories: (1) hematological (including febrile neutropaenia, thrombocytopenia, coagulopathies), (2) gastrointestinal (gastric outlet and biliary obstruction, gastrointestinal bleeding), (3) thromboembolic events, (4) ascites, (5) metabolic disorders and (6) neurologic complications. The pathogenesis, frequency, related symptoms as well as appropriate investigations are also presented. Conclusion Patients with PB malignancies are at increased risk of a wide variation of medical emergencies. Clinical knowledge, early recognition and collaboration with the relevant specialties are critical to manage these complications effectively, tailoring overall management around the actual prognosis and individuals’ expectations.
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- 2021
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100. Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study
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Akowuah, Enoch, Benson, Ruth A., Caruana, Edward J., Chetty, Govind, Edwards, John, Forlani, Stefano, Gradinariu, George, Murphy, Gavin J., Oo, Aung Ye, Patel, Akshay J., Ridley, Brenda, Rogers, Luke J., Sanders, Julie, Tyson, Nathan, Vaja, Ricky, Siaw-Acheampong, Kwabena, Argus, Leah, Chaudhry, Daoud, Dawson, Brett E., Glasbey, James C., Gujjuri, Rohan R., Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Keatley, James M., Lawday, Samuel, Li, Elizabeth, Mann, Harvinder, Marson, Ella J., Mclean, Kenneth A., Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Nepogodiev, Dmitri, Dajti, Irida, Gjata, Arben, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohanes, Hailu, Dr. Samuel, Tamiru, Hailu, Kauppila, Joonas, Laukkarinen, Johanna, Arnaud, Alexis, Albertsmeiers, Markus, Lederhuber, Hans, Loffler, Markus, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tamas, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Faris, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moises, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andreas, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelos, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Dennis, Simoes, Joana F. F., Dajti, I., Valenzuela, J. I., Boccalatte, L. A., Gemelli, N. A., Smith, D. E., Dudi-Venkata, N. N., Kroon, H. M., Sammour, T., Roberts, M., Mitchell, D., Lah, K., Pearce, A., Morton, A., Dawson, A. C., Drane, A., Sharpin, C., Nataraja, R. M., Pacilli, M., Cox, D. R. A., Muralidharan, V., Riddiough, G. E., Clarke, E. M., Jamel, W., Qin, K. R., Pockney, P., Cope, D., Egoroff, N., Lott, N., Putnis, S., De Robles, S., Ang, Z., Mitteregger, M., Uranitsch, S., Stiegler, M., Seitinger, G., Aigner, F., Lumenta, D. B., Nischwitz, S. P., Richtig, E., Pau, M., Srekl-Filzmaier, P., Eibinger, N., Michelitsch, B., Fediuk, M., Papinutti, A., Seidel, G., Kahn, J., Cohnert, T. U., Messner, F., Öfner, D., Presl, J., Varga, M., Weitzendorfer, M., Emmanuel, K., Binder, A. D., Zimmermann, M., Holawe, S., Nkenke, E., Grimm, C., Kranawetter, M., Rahman Mitul, A., Islam, N., Karim, S., Komen, N., Ang, E., De Praetere, H., Tollens, T., Schols, G., Smets, C., Haenen, L., Quintens, J., Van Belle, K., Van Ramshorst, G. H., Pattyn, P., Desender, L., Martens, T., Van de putte, D., Lerut, P., Grimonprez, A., Janssen, M., De Smul, G., Wallaert, P., Van den Eynde, J., Oosterlinck, W., Van den Eynde, R., Sermon, A., Boeckxstaens, A., Cordonnier, A., De Coster, J., Jaekers, J., Politis, C., Miserez, M., Duchateau, N., De Gheldere, C., Flamey, N., Christiano, A., Guidi, B., Minussi, A. L., Castro, S., Okoba, W., Maldonado, F. H. R., Oliveira, P., Baldasso, T., Santos, L., Gomes, G. M. A., Buarque, I. L., Pol-Fachin, L., Bezerra, T. S., Barros, A. V., da Silva, A. M. R., Leite, A. L. S., Silvestre, D. W. A., Ferro, C. C., Araujo, M. S., Lopes, L. M., Damasceno, P. D., Araujo, D. H. S., Laporte, G., Salem, M. C., Guimaraes-Filho, M. A. C., Nacif, L., Flumignan, R. L. G., Nakano, L. C. U., Kuramoto, D. A. B., Aidar, A. L. S., Pereda, M. R., Correia, R. M., Santos, B. C., Carvalho, A. A., Amorim, J. E., Guedes Neto, H. J., Areias, L. L., Sousa, A. F., Flumignan, C. D. Q., Lustre, W. G., Moreno, D. H., Barros, N., Baptista-Silva, J. C. C., Matos, L. L., Kowaski, L. P., Kulcsar, M. A. V., Nunes, K. S., Teixeira, M. F., Nunes, R. L., Ijichi, T. R., Kim, N. J., Marreiro, A., Muller, B., Barakat Awada, J., Baiocchi, G., Kowalski, L. P., Vartanian, J. G., Makdissi, F. B., Aguiar, S., Marques, N., Carvalho, G. B., Marques, T. M. D. M., Abdallah, E. A., Zurstrassen, C. E., Gross, J. L., Zequi, S. C., Gonçalves, B. T., Santos, S. S., Duprat, J. P., Coimbra, F. J. F., Cicco, R., Takeda, F., Cecconello, I., Ribeiro, U., Gatti, A., Oliva, R., Nardi, C., Slavchev, M., Atanasov, B., Belev, N., Dell, A., Bigam, D., Dajani, K., Al Riyami, S., Martin, J., Cheng, D., Yang, H., Fayad, A., Carrier, F. M., Amzallag, E., Desroches, J., Ruel, M., Caminsky, N. G., Boutros, M., Moon, J., Wong, E. G., Vanounou, T., Pelletier, J., Wong, S., Girsowicz, E., Bayne, J., Obrand, D., Gill, H., Steinmetz, O., MacKenzie, K., Lukaszewski, M., Jamjoum, G., Richebé, P., Verdonck, O., Discepola, S., Godin, N., Idrissi, M., Briatico, D., Sharma, S., Talwar, G., Bailey, K., Lecluyse, V., Côté, G., Demyttenaere, S., Garfinkle, R., Kouyoumdjian, A., Dumitra, S., Khwaja, K., Luo, L., Berry, G., Liberman, A. S., Schmid, S., Spicer, J., Al Farsi, M., Abou-Khalil, J., Couture, E., Mohammadi, S., Tremblay, H., Gagné, N., Bergeron, A., Turgeon, Af, Costerousse, O., Bellemare, D., Babin, C., Blier, C., Wood, M. L., Persad, A., Groot, G., Pham, H., D'Aragon, F., Carbonneau, E., Bouchard, M., Masse, M., Pesant, F., Héroux, J., Karanicolas, P., Hallet, J., Nadler, A., Nathens, A., Ko, M., Brar, A., Mayson, K., Kidane, B., Srinathan, S., Escudero, M. I., Reyes, J. T., Modolo, M. M., Ramirez Nieto, P., Sepulveda, R., Bolbarán, A., Molero, A., Ruiz, I., Reyes, G. P., Salas, R., Suazo, C., Muñoz, R., Grasset, E., Inzunza, M., Besser, N., Irarrázaval, M. J., Jarry, C., Bellolio, F., Romero Manqui, C. A., Ruiz Esquide, M., Fuentes, T., Campos, J., Perez Rivera, C. J., Cabrera, P. A., Pinilla, R. E., Guevara, O., Jimenez Ramirez, L. J., Velasquez Cuasquen, B. G., Herrera Mora, D. R., Bonilla, A., Diaz, S., Manrique, E., Facundo, H., Velez Bernal, J. L., Ángel, J., García, M., Guzmán, L., Lehmann, C., Cervera, S., Trujillo Sanchez, L. M., Guevara, R., Valbuena, D., Suarez, L., Jimenez, G., Velandia, A., Vargas, J., Espinosa, J., Rey, S., Mendoza Quevedo, Jairo, Calvache, J. A., Orozco-Chamorro, C. M., Sánchez-Gómez, T. A., Rojas-Tejada, D. A., Mihanovic, J., Bakmaz, B., Rakvin, I., Sulen, N., Andabaka, T., Luksic, I., Mamic, M., Martinek, L., Skrovina, M., Žatecký, J., Peteja, M., Kristensen, H. Ø., Mekhael, M., Christensen, P., Westh, L., Smith, H., Haugstvedt, A. F., Jönsson, M. L., Crespo, A., Batista, S., Rodriguez-Abreu, J., Tactuk, N., Diaz-Delgado, P. J., Rivas, R., Sarmiento-Bobadilla, J. A., Ashoush, F., Samir Abdelaal, A., Qatora, M. S., Elsayed Hewalla, M. E., Metwalli, M., Atta, R., Abdelmajeed, A., Abosamak, N. E., Sabry, A., Shehata, S., Sallam, I., Amira, G., Sherief, M., Sherif, A., Salem, H., Hamdy, R., Aboulkassem, H., Ghaly, G., Sherif, G., Morsi, A., Abdelrahman, A., Omnia, Ahmed, Tawheed, A., El Kassas, M., Omar, W., Abdelsamed, A., Seleim, A., Azzam, A. Y., ElFiky, M., Nabil, A., Ibraheem, M., ELDeeb, M., Fawzy, M., Hamed, H., Emile, S., Elfallal, A., Elfeki, H., Shalaby, M., Sakr, A., Alrahawy, M., Atif, H., Soltan, H., Sayed, A. K., Salah, A., Atiya, A., Wassim, K., Abbas, A. M., Abd Elazeem, H. A. S., Abd-Elkariem, A. Y., Abd-Elkarem, M. M., Alaa, S., Ali, A. K., Ashraf, M., Ayman, A., Azizeldine, M. G., Elkhayat, H., Emad Mashhour, A., Gaber, M., Hamza, H. M., Hawal, I., Hetta, H. F., Elghazaly, S. M., Mohammed, M. M., Monib, F. A., Nageh, M. A., Saad, A., Saad, M. M., Shahine, M., Yousof, E. A., Youssef, A., Esmail, E., Khalaf, M., Eldaly, A., Ghoneim, A., Hawila, A., Badr, H., Elhalaby, I., Abdel-bari, M., Elbahnasawy, M., Hamada, M. K., Morsy, M. S., Hammad, M., Essa, M., Fayed, M. T., Elzoghby, M., Rady, M., Hamad, O., Salman, S., Sarsik, S., Abd-elsalam, S., Gamal Badr, S., El-Masry, Y., Moahmmed, M. M. H., Hailu, S., Wolde, A., Mengesha, M., Nida, S., Workneh, M., Y Ahmed, M., Fisseha, T., Kassa, D., Zeleke, H., Admasu, A., Laeke, T., Tirsit, A., Gessesse, M., Addissie, A., Bekele, D., Kauppila, J. H., Sarjanoja, E., Testelin, S., Dakpé, S., Devauchelle, B., Bettoni, J., Lavagen, N., Schmitt, F., Lemée, J. M., Boucher, S., Breheret, R., Kün-Darbois, J. D., Kahn, A., Gueutier, A., Bigot, P., Borraccino, B., Lakkis, Z., Doussot, A., Heyd, B., Manfredelli, S., Mathieu, P., Paquette, B., Turco, C., Barrabe, A., Louvrier, A., Moszkowicz, D., Giovinazzo, D., Bretagnol, F., Police, A., Charre, L., Volpin, E., Braham, H., El Arbi, N., Villefranque, V., Bendjemar, L., Girard, E., Abba, J., Trilling, B., Chebaro, A., Lecolle, K., Truant, S., El Amrani, M., Zerbib, P., Pruvot, F. R., Mathieu, D., Surmei, E., Mattei, L., Marin, H., Christou, N., Ballouhey, Q., Ferrero, P., Coste Mazeau, P., Tricard, J., Barrat, B., Taibi, A., Usseglio, J., Laloze, J., Salle, H., Fourcade, L., Duchalais, E., Regenet, N., Rigaud, J., Waast, D., Denis, W., Malard, O., Buffenoir, K., Espitalier, F., Ferron, C., Varenne, Y., Crenn, V., De Vergie, S., Cristini, J., Samarut, E., Tzedakis, S., Bouche, P. A., Gaujoux, S., Kantor, E., Gossot, D., Seguin-Givelet, A., Fuks, D., Grigoroiu, M., Sanchez Salas, R., Cathelineau, X., Macek, P., Barbé, Y., Rozet, F., Barret, E., Mombet, A., Cathala, N., Brian, E., Zadegan, F., Conso, C., Blanc, T., Broch, A., Sarnacki, S., Ali, L., Bonnard, A., Peycelon, M., Hervieux, E., Clermidi, P., Maisonneuve, E., Aubry, E., Thomin, A., Langlais, T., Passot, G., Glehen, O., Cotte, E., Lifante, J. C., De Simone, B., Chouillard, E., Arnaud, A. P., Violas, P., Bergeat, D., Merdrignac, A., Scalabre, A., Perotto, L. O., Le Roy, B., Haddad, E., Vermersch, S., Ezanno, A. C., Barbier, O., Vigouroux, F., Malgras, B., Aime, A., Seeliger, B., Mutter, D., Philouze, G., Pessaux, P., Germain, A., Chanty, H., Ayav, A., Kassir, R., Von theobald, P., Sauvat, F., O'Connor, J., Mayombo Idiata, M., O'Connor, Z., Tchoba, S., Modabber, A., Winnand, P., Hölzle, F., Sommer, B., Shiban, E., Wolf, S., Anthuber, M., Sommer, F., Kaemmerer, D., Schreiber, T., Kamphues, C., Lauscher, J. C., Schineis, C., Loch, F. N., Beyer, K., Nasser, S., Sehouli, J., Höhn, P., Braumann, C., Reinkemeier, F., Uhl, W., Weitz, J., Bork, U., Welsch, T., Praetorius, C., Korn, S., Distler, M., Fluegen, G., Knoefel, W. T., Vay, C., Golcher, H., Grützmann, R., Binder, J., Meister, P., Gallinat, A., Paul, A., Schnitzbauer, A. A., Thoenissen, P., El Youzouri, H., Schreckenbach, T., Nguyen, T. A., Eberbach, H., Bayer, J., Erdle, B., Sandkamp, R., Nitschke, C., Izbicki, J., Uzunoglu, F. G., Koenig, D., Gosau, M., Böttcher, A., Heuer, A., Klatte, T. O., Priemel, M., Betz, C. S., Burg, S., Möckelmann, N., Busch, C. J., Bewarder, J., Zeller, N., Smeets, R., Thole, S., Vollkommer, T., Speth, U., Stangenberg, M., Hakami, I., Boeker, C., Mall, J., Schardey, H. M., von Ahnen, T., von Ahnen, M., Brunner, U., Tapking, C., Kneser, U., Hirche, C., Jung, M., Kowalewski, K. F., Kienle, P., Reissfelder, C., Seyfried, S., Herrle, F., Hardt, J., Galata, C., Birgin, E., Rahbari, N., Vassos, N., Stoleriu, M. G., Hatz, R., Albertsmeier, M., Börner, N., Lampert, C., Werner, J., Kuehlmann, B., Prantl, L., Brunner, S. M., Schlitt, H. J., Brennfleck, F., Pfister, K., Oikonomou, K., Reinhard, T., Nowak, K., Ronellenfitsch, U., Kleeff, J., Delank, K. S., Michalski, C. W., Szabo, G., Widyaningsih, R., Stavrou, G. A., Bschorer, R., Mielke, J., Peschel, T., Königsrainer, A., Quante, M., Löffler, M. W., Yurttas, C., Doerner, J., Seiberth, R., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Syllaios, A., Baili, E., Schizas, D., Liakakos, T., Charalabopoulos, A., Zografos, C., Spartalis, E., Manatakis, D. K., Tasis, N., Antonopoulou, M. I., Xenaki, S., Xynos, E., Chrysos, E., Athanasakis, E., Tsiaousis, J., Lostoridis, E., Tourountzi, P., Tzovaras, G., Tepetes, K., Zacharoulis, D., Baloyiannis, I., Perivoliotis, K., Hajiioannou, J., Korais, C., Gkrinia, E., Skoulakis, C. E., Saratziotis, A., Koukoura, O., Symeonidis, D., Diamantis, A., Tsoulfas, G., Christou, C. D., Tooulias, A., Papadopoulos, V., Anthoulakis, C., Grimbizis, G., Zouzoulas, D., Tsolakidis, D., Tatsis, D., Christidis, P., Loutzidou, L., Ioannidis, O., Astreidis, I., Antoniou, A., Antoniadis, K., Vachtsevanos, K., Paraskevopoulos, K., Kalaitsidou, I., Alexoudi, V., Stavroglou, A., Mantevas, A., Michailidou, D., Grivas, T., Deligiannidis, D., Politis, S., Barrios Duarte, A., Portilla, A. L., Lowey, M. J., Recinos, G., Lopez Muralles, I., Siguantay, M. A., Estrada, E. E., Aguilera-Arévalo, M. L., Cojulun, J. M., Echeverría-Dávila, G., Marín, C., Icaza de Marín, G. C., Kok, S. Y., Joeng, H. K. M., Chan, L. L., Lim, D., Novak, Z., Echim, T., Suszták, N., Banky, B., Kembuan, G., Pajan, H., Islam, A. A., Rahim, F., Safari, H., Mozafari, M., Brouki Milan, P., Tizmaghz, A., Rezaei Tavirani, M., Ahmed, A., Hussein, R., Fleming, C., O'Brien, S., Kayyal, M. Y., Daly, A., Killeen, S., Corrigan, M., De Marchi, J., Hill, A., Farrell, T., Davis, N. F., Kearney, D., Nelson, T., Maguire, P. J., Barry, C., Farrell, R., Smith, L. A., Mohan, H. M., Mehigan, B. J., Mccormick, P., Larkin, J. O., Fahey, B. A., Rogers, A., Donlon, N., O'Sullivan, H., Nugent, T., Reynolds, J. V., Donohue, C., Shokuhi, P., Ravi, N., Fitzgerald, C., Lennon, P., Timon, C., Kinsella, J., Smith, J., Boyle, T., Alazawi, D., Connolly, E., Butt, W., Croghan, S. M., Manecksha, R. P., Fearon, N., Winter, D., Heneghan, H., Maguire, D., Gallagher, T., Conlon, K., Kennedy, N., Martin, S., Kennelly, R., Hanly, A., Ng, K. C., Fagan, J., Geary, E., Cullinane, C., Carrington, E., Geraghty, J., McDermott, E., Pritchard, R., McPartland, D., Boland, M., Stafford, A., Geoghegan, J., Elliott, J. A., Ridgway, P. F., Gillis, A. E., Bass, G. A., Neary, P. C., O'Riordan, J. M., Kavanagh, D. O., Reynolds, I. S., K, Conlon, Joyce, D. P., Boyle, E., Egan, B., Whelan, M., Elkady, R., Tierney, S., Connelly, T. M., Earley, H., Umair, M., O'Connell, C., Thomas, A. Z., Rice, D., Madden, A., Bashir, Y., Creavin, B., Cullivan, O., Owens, P., Canas-Martinez, A., Murphy, C., Pickett, L., Murphy, B., Mastrosimone, A., Beddy, D., Arumugasamy, M., Allen, M., Aremu, M., McCarthy, C., O’Connor, C., O'Connor, D. B., Kent, E., Malone, F., Geary, M., McKevitt, K. L., Lowery, A. J., Ryan, É. J., Aherne, T. M., Fowler, A., Hassanin, A., Hogan, A. M., Collins, C. G., Finnegan, L., Carroll, P. A., Kerin, M. J., Walsh, S. R., Nally, D., Peirce, C., Coffey, J. C., Cunningham, R. M., Tormey, S., Hardy, N. P., Neary, P. M., Muallem-Kalmovich, L., Kugler, N., Lavy, R., Zmora, O., Horesh, N., Vergari, R., Mochet, S., Barmasse, R., Usai, A., Morelli, L., Picciariello, A., Papagni, V., Altomare, D. F., Colledan, M., Zambelli, M. F., Tornese, S., Camillo, A., Rausa, E., Bianco, F., Lucianetti, A., Prucher, G. M., Baietti, A. M., Ruggiero, F., Maremonti, P., Neri, F., Ricci, S., Biasini, M., Zarabini, A. G., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Della Gatta, A. N., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pilu, G., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Tonini, V., Sartarelli, L., Cervellera, M., Gori, A., Armatura, G., Scotton, G., Patauner, S., Frena, A., Podda, M., Pisanu, A., Esposito, G., Frongia, F., Abate, E., Laface, L., Casati, M., Schiavo, M., Casiraghi, T., Sammarco, G., Gallo, G., Vescio, G., Fulginiti, S., Scorcia, V., Giannaccare, G., Carnevali, A., Giuffrida, M. C., Marano, A., Palagi, S., Di Maria Grimaldi, S., Testa, V., Peluso, C., Borghi, F., Simonato, A., Puppo, A., D'Agruma, M., Chiarpenello, R., Pellegrino, L., Maione, F., Cianflocca, D., Pruiti Ciarello, V., Giraudo, G., Gelarda, E., Dalmasso, E., Abrate, A., Daniele, A., Ciriello, V., Rosato, F., Garnero, A., Leotta, L., Giacometti, M., Zonta, S., Lomiento, D., Taglietti, L., Dester, S., Compagnoni, B., Viotti, F., Cazzaniga, R., Del Giudice, R., Mazzotti, F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C. V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A. L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M. G., Lippa, L., Gambacciani, C., Santonocito, O. S., Aquila, F., Pieri, F., Ballabio, M., Bisagni, P., Longhi, M., Armao, T., Madonini, M., Gagliano, A., Pizzini, P., Costanzi, A., Confalonieri, M., Monteleone, M., Colletti, G., Frattaruolo, C., Mari, G., Spinelli, A., Mercante, G., Spriano, G., Gaino, F., Ferreli, F., De Virgilio, A., Rossi, V., Carvello, M. M., Di Candido, F., Kurihara, H., Marrano, E., Torzilli, G., Castoro, C., Carrano, F. M., Martinelli, F., Macchi, A., Fiore, M., Pasquali, S., Cioffi, S. P. B., Baia, M., Abatini, C., Sarre, C., Mosca, A., Biasoni, D., Gronchi, A., Citterio, D., Mazzaferro, V., Cadenelli, P., Gennaro, M., Capizzi, V., Guaglio, M., Sorrentino, L., Bogani, G., Sarpietro, G., Giannini, L., Comini, L. V., Rolli, L., Folli, S., Raspagliesi, F., Piazza, C., Cosimelli, M., Salvioni, R., Antonelli, B., Baldari, L., Boni, L., Cassinotti, E., Pignataro, L., Rossi, G., Torretta, S., Beltramini, G. A., Gianni', A., Tagliabue, M., De Berardinis, R., Pietrobon, G., Chu, F., Cenciarelli, S., Adamoli, L., Ansarin, M., Fumagalli Romario, U., Mastrilli, F., Mariani, N. M., Nicastro, V., Cellerino, P., Colombo, F., Frontali, A., Bondurri, A., Guerci, C., Maffioli, A., Ferrario, L., Candiani, M., Bonavina, G., Ottolina, J., Valsecchi, L., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Negri, G., Bandiera, A., De Nardi, P., Sileri, P., Carlucci, M., Pelaggi, D., Rosati, R., Vignali, A., Parise, P., Elmore, U., Tamini, N., Nespoli, L. C., Rennis, M., Pitoni, L., Chiappetta, M. F., Vico, E., Fruscio, R., Grassi, T., Sasia, D., Migliore, M., Gattolin, A., Rimonda, R., Travaglio, E., Olearo, E., Tufo, A., Marra, E., Maida, P., Marte, G., Tammaro, P., Incollingo, P., Izzo, F., Belli, A., Patrone, R., Albino, V., Leongito, M., Granata, V., Piccirillo, M., Palaia, R., Francone, E., Gentilli, S., Nikaj, H., Fiorini, A., Norcini, C., Chessa, A., Marino, M. V., Mirabella, A., Vaccarella, G., Musini, L., Ampollini, L., Bergonzani, M., Varazzani, A., Bellanti, L., Domenichini, M., Cabrini, E., Fornasari, A., Freyrie, A., Dejana, D. O., D'Angelo, G., Bertoli, G., Di Lella, F., Bocchialini, G., Falcioni, M., Lanfranco, D., Poli, T., Giuffrida, M., Annicchiarico, A., Perrone, G., Catena, F., Raffaele, A., De Manzoni Garberini, A., Baldini, E., Conti, L., Ribolla, M., Capelli, P., Isolani, S. M., Maniscalco, P., Cauteruccio, M., Ciatti, C., Puma Pagliarello, C., Gattoni, S., Galleano, R., Malerba, M., Ciciliot, M., Farnesi, F., Calabrò, M., Pipitone Federico, N. S., Lunghi, E. G., Muratore, A., Di Franco, G., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Simoncini, T., Gadducci, A., Caretto, M., Giannini, A., Perutelli, A., Domenici, L., Garibaldi, S., Capanna, R., Andreani, L., Furbetta, N., Guadagni, S., Bianchini, M., Gianardi, D., Pinotti, E., Montuori, M., Carissimi, F., Baronio, G., Zizzo, M., Castro Ruiz, C., Annessi, V., Montella, M. T., Falco, G., Mele, S., Ferrari, G., Mastrofilippo, V., Mandato, V. D., Aguzzoli, L., Corbellini, C., Baldi, C., Sampietro, G. M., Palini, G. M., Zanini, N., Garulli, G., Barone, R., Murgese, A., Mungo, S., Grasso, M., Marafante, C., Birolo, S. L., Moggia, E., Caccetta, M., Masciandaro, A., Deirino, A., Garino, M., Perinotti, R., Maiello, F., Gordini, L., Lombardi, C. P., Marzi, F., Marra, A. A., Ratto, C., Di Muro, M., Litta, F., De Simone, V., Cozza, V., Rosa, F., Agnes, A., Parello, A., Alfieri, S., Sganga, G., Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G. B., Cicerchia, P. M., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Sagnotta, A., Marino Cosentino, L., Mancini, S., Lisi, G., Spoletini, D., Bellato, V., Campanelli, M., Sica, G., Siragusa, L., Bonavina, L., Asti, E., Bernardi, D., Lovece, A., Perra, T., Porcu, A., Fancellu, A., Feo, C. F., Scanu, A. M., Tuminello, F., Franceschi, A., Langone, A., Fleres, F., Spolini, A., Bordoni, P., Franzini, M., Clarizia, G., Grechi, A., Longhini, A., Guaitoli, E., Manca, G., Grossi, U., Novello, S., Zanus, G., Romano, M., Rossi, S., Ferrara, F., La Torre, M., Pirozzolo, G., Recordare, A., Paiella, S., Turri, G., Rattizzato, S., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Ruzzenente, A., Poletto, E., Conci, S., Casetti, L., Fontana, M., Salvia, R., Malleo, G., Esposito, A., Landoni, L., De Pastena, M., Bassi, C., Tuveri, M., Nobile, S., Marchegiani, G., Bortolasi, L., Sambugaro, E., Malavolta, M., Moretto, G., Impellizzeri, H., Inama, M., Barugola, G., Ascari, F., Ruffo, G., Granieri, S., Cotsoglou, C., Berselli, M., Desio, M., Marchionini, V., Cocozza, E., Di Saverio, S., Ietto, G., Iovino, D., Carcano, G., Ayasra, F., Qasem, A., Ayasra, Y., Al-Masri, M., Abou Chaar, M. K., Al-Najjar, H., Ghandour, K., Alawneh, F., Abdel Jalil, R., Abdel Al, S., Elayyan, M., Ghanem, R., Lataifeh, I., Alsaraireh, O., Abu Za’nouneh, F. J., Fahmawee, T., Ibrahim, A., Obeidat, K., Lee, K. J., Shin, S. J., Chung, H., Albader, I., Alabbad, J., Albader, M. A. S., Bouhuwaish, A., Taher, A. S., Omar, M. S. M., Abdulwahed, E., Biala, M., Morgom, M., Elhadi, A., Alarabi, A., Msherghi, A., Elhajdawe, F., Alsoufi, A., Salamah, A., Salama, H., Bulugma, M., Almabrouk, H., Venskutonis, D., Dainius, E., Kubiliute, E., Bradulskis, S., Parseliunas, A., Kutkevicius, J., Subocius, A., Cheong, Y. J., Masood, M. S., Ngo, C. W., Saravanan, R., Abdul Maei, N., Hayati, F., Amin Sahid, N., Yanowsky Reyes, G., Orozco Perez, J., Damian, R., Santana Ortiz, R., Colunga Tinajero, C. A., Cordera, F., Gómez-Pedraza, A., Maffuz-Aziz, A., Posada, J. A., De la Rosa Abaroa, M. A., Alvarez, M. R., Arrangoiz, R., Hernández, R., Bozada Gutierrez, K., Trejo-Avila, M., Valenzuela-Salazar, C., Herrera-Esquivel, J., Moreno-Portillo, M., Pinto-Angulo, V. M., Sosa-Duran, E. E., Ziad-Aboharp, H., Jimenez Villanueva, X., Soulé Martínez, C. E., Lupián-Angulo, A. I., Martínez Zarate J, Jacobo, Reyes Rodriguez, E., Montalvo Dominguez, G., Becerra García, F. C., Melchor-Ruan, J., Vilar-Compte, D., Romero-Bañuelos, E., Herrera-Gomez, A., Meneses-Garcia, A., Isla-Ortiz, D., Salcedo-Hernández, R. A., Hernández-Nava, J. M., Morales-Castelan, J. E., Posadas-Trujillo, O. E., Buerba, G. A., Alfaro-Goldaracena, A., Pena Gomez-Portugal, E., Lopez-Pena, G., Hinojosa, C. A., Mercado, M. A., Ramos-De la Medina, A., Martinez, L., Duran, I., Gonzalez, D. S., Martinez, M. J., Nayen Sainz de la Fuente, A., Miguelena, L., Hernández Miguelena, L., Louraoui, S. M., El Azhari, A., Rghioui, M., Khya, E., Ghannam, A., Souadka, A., El Ahmadi, B., Belkhadir, Z. H., Majbar, M. A., Benkabbou, A., Mohsine, R., Oudrhiri, M. Y., Bechri, H., Arkha, Y., El Ouahabi, A., Frima, H., Bachiri, S., Groen, L. C., Verhagen, T., ter Brugge, F. M., Scheijmans, J. C. G., Boermeester, M. A., Hompes, R., Meima-van Praag, E. M., Sharabiany, S., Borgstein, A. B. J., Gisbertz, S. S., van Berge Henegouwen, M. I., Gans, S., Van Duijvendijk, P., Herklots, T., De Hoop, T., De Graaff, M. R., Sloothaak, D., Bolster-van Eenennaam, M., Baaij, J., Klinkenbijl, J. H. G., Van Eekeren, R., Spillenaar Bilgen, E. J., Van der Burg, S. W., Harlaar, N. J., Jonker, F. H. W., Vermaas, M., Voigt, K. R., Nellensteijn, D., Bensi, E. A. B., Posma-Bouman, L., Van Sambeek, M., Holscher, M., Van den den Broek, W. T., HKruijff, S., De Vries, J. P. P. M., Steinkamp, P. J., Jonker, P. K. C., Van der Plas, W. Y., Bierman, W., Janssen, Y., Franken, J., Oosterling, S., Boerma, E. G., Schweitzer, D., Keulen, M. H. F., Ketting, S., Wegdam, J. A., Vries Reilingh, T. S., de Schipper, Teeuwen, P. H. E., Hendriks, E. R., Van Geloven, A. A. W., Emous, M., Poelstra, R., Teunissen, M., Gerritsen, S. L., Boerma, D., De Reuver, P. R., Thunnissen, F., Vermeulen, B. A. M., Groen, A., Van Ginhoven, T. M., Viëtor, C. L., van der Oest, M. J. W., Vriens, P. W. H. E., Houwen, T., Heisterkamp, J., van Petersen, A. S., van der Meij, W., Stevens, C. T., Pronk, A., Bakker, W. J., Richir, M. C., Vriens, M. R., Filipe, M. D., Uittenbogaart, M., Leclercq, W. K. G., Sijmons, J. M. L., Vancoillie, P. J., Konsten, J., Van Heinsbergen, M., Dekker, N. A. M., den Boer, F. C., Akinmade, A., Adeyeye, A., Enoch, E., Fayose, S., Okunlola, A. I., Adeniyi, A. A., Adeyemo, O. T., Adebara, I. O., Bakare, A., Babalola, O. F., Abiyere, O. H., Banjo, O. O., Olori, S., Akaba, O. G., Agida, E. T., Abdullahi, I. H., Egbuchulem, I. K., Olulana, D., Lawal, T. A., Ogundoyin, O., Oyelakin, O. A., Nwaorgu, O. G., Sule, S. O., Makwe, C. C., Afolabi, B. B., Seyi-Olajide, J. O., Ademuyiwa, A. O., Bode, C. O., Atoyebi, O., Elebute, O. A., Okunowo, A. A., Williams, O. M., Eke, N. G., Oshodi, O. A., Faboya, O. M., Adeniran, A. S., Omisanjo, O. A., Oshodi, Y. A., Ogunyemi, A. A., Atobatele, K. M., Aremu, I., Olasehinde, O., Abdur-Rahman, L., Bello, J., Popoola, A., Sayomi, T. O., Raji, H. O., Adeleke, N., Lawal, B., Habeeb, O., Agodirin, O., Tolani, M. A., Sholadoye, T. T., Nwabuoku, S. E., Abubakar, M., Risteski, T., Cvetanovska Naunova, V., Jovcheski, L., Lazova, E., Agledahl, I., Breuer, R. G., Massoud, J., Waqar, S. H., Rashid, I., Ayubi, A., Bhatti, A. B. H., Younis, M. U., Ghouri, A., Ayub, B., Sayyed, R. H., Saleem, A., Turk, K., Alvi, A., Abassy, J., Khan, S., Arshad, M., Ahmed, K., Siddiqui, T., Pirzada, A., Kerawala, A. A., Jamal, A., Rai, L., Nafees Ahmed, R., Memon, A. S., Qureshi, A. U., Ayyaz, M., Umar, M., Butt, U., Kashif, M., Khan, W. H., Waris Farooka, M., Wasim, T., Talat, N., Tahir, W., Naseem, J., Akbar, A., Afroze, S., Sultan, A., Ali, H. B., Janjua, M. H., Janjua, A., Asghar, S., Farooq, M. S., Sarwar, M. Z., Naqi, S. A., Gondal, K. M., Bukhari, S. I., Tariq, M., Javed, S., Yaqoob, E., Mahmood, U., Raja Shabbir, K., Abukhalaf, S. A., Amro, A., Cabada Lee, J. M., Aguilar, A., Rodriguez, E., Castillo, K., Cukier, M., Rodriguez-Zentner, H., Arrue, E., Isaacs Beron, R., Rodríguez Gonzalez, A., Panduro-Correa, V., Cornelio, D. K., Otiniano Alvarado, C. E., Caballero Sarabia, V. D., Vasquez-Ojeda, X. P., Lizzetti-Mendoza, G., Niquen-Jimenez, M., Shu-Yip, S. B., León Palacios, J. L., Borda-Luque, G., Zegarra, S. A., Huamán Egoávil, E., Suazo Carmelo, C., Castro de la Mata, R., Rivas, D., Targarona, J., Trujillo, Y., Olivera Villanueva, M., Lahoud-Velaochaga, A., Cabillas, K., Castañeda, W., Colina Casas, J., Betalleluz Pallardel, J., Camacho Zacarías, F., Vélez Segura, E., Cruz Condori, D. L., Huamán, E., Ugarte Oscco, R., Vergel Cabrera, C., Carpio Colmenares, Y. T., García Barrionuevo, L. A., Cárdenas Ruiz de Castilla, D., Mansilla Doria, P., Li Valencia, M. R., Salazar, A., Sarmiento, A., Díaz, C., Morales, E., Ore, E., Zegarra, H., Siccha, J., Guardia, M., Sandoval, M., Mendiola, G. C., Mimbela, M., Diaz-Ruiz, R., Zeta, L. A., Cordova-Calle, E., Nuñez, H. M., Ortiz-Argomedo, M. R., Caballero-Alvarado, J., Salazar-Tantaleán, A., Espinoza-Llerena, R., Aliaga-Ramos, M., Asodisen, O., Jabagat, E., Tedoy, C. M., Ramos, R. A., Lopez, M. P. J., Violago, K. L. E., Aram, R., Carlos Santos, P., Filarca, R. F., Carlos, A., Santos, P., Filarca, R. L., Domingo, E. J., Khu, K. J. O., Lapitan, M. C., Sacdalan, M. D. P., Kho, M. J. N., Baticulon, R. E., Bravo, S. L. R., Cueto, M. A. C., Ramos, C. L., Fuentes, J. R., Sadian, H., Gumarao, A., Barraquio, A., Cruz, E. M., Gonzales, A. D., Reyes, J. A. S., Salud, J. A., Tancinco, E. G., Rivera, R. D., Lim, J. A., Barcelon, J. C., Chiu, J. A., Carballo, M. I., Major, P., Gawron, I., Jach, R., Borges, F., Matos Costa, P., Henriques, S., Rodrigues, S. C., Gonçalves, N., Curvas, J. M., Cabeleira, A., Branco, C., Serralheiro, P., Alves, R., Teles, T., Lázaro, A., Canhoto, C., Simões, J., Costa, M., Almeida, A. C., Nogueira, O., Oliveira, A., Athayde Nemésio, R., Silva, M., Lopes, C., Amaral, M. J., Valente da Costa, A., Andrade, R., Martins, R., Guimarães, A., Guerreiro, P., Ruivo, A., Camacho, C., Duque, M., Santos, E., Breda, D., Oliveira, J. M., De Oliveira Lopez, A. L., Garrido, S., Colino, M., De Barros, J., Correia, S., Rodrigues, M., Cardoso, P., Teixeira, J., Soares, A. P., Morais, H., Pereira, R., Revez, T., Manso, M. I., Domingues, J. C., Henriques, P., Ribeiro, R., Ribeiro, V. I., Cardoso, N., Sousa, S., Martins dos Santos, G., Carvalho, L., Osório, C., Antunes, J., Lourenço, S., Balau, P., Godinho, M., Pereira, A., Silva, N., Kam da Silva Andrade, A., Pereira Rodrigues, A., Borges, N., Correia, J., Vieira, I., Ribeiro, T., Catarino, J., Correia, R., Pais, F., Carreira Garcia, R., Bento, R., Cardoso, J., Luis, M., Henriques, J., Patena Forte, J., Maciel, J., Pinheiro Santos, J., Silva, T. P., Branquinho, A., Caiado, A., Miranda, P., Garrido, R., Peralta Ferreira, M., Ascensão, J., Costeira, B., Cunha, C., Rio Rodrigues, L., Sousa Fernandes, M., Azevedo, P., Ribeiro, J., Lourenço, I., Gomes, H., Mendinhos, G., Nobre Pinto, A., Ribeiro, A., Gil, C. G., Lima-da-Silva, C., Pereira, C., Tavares, F., Ferraz, I., Almeida, J. I., Marialva, J., Lopes, L., Costa, M. J. M. A., Nunes-Coelho, M., Teixeira, M. J., Machado, N., Alfonso, J. P., Saraiva, P., Silva, R. L., Santos, R., Almeida-Reis, R., Correia-de-Sá, T., Fernandes, V., Almeida-Pinto, J., Gonçalves, J. P., Santos-Sousa, H., Cavaleiro, S., Leite-Moreira, A. M., Pereira-Neves, A., Faria, C. S., Monteiro, J. M., Nogueiro, J., Sampaio-Alves, M., Magalhães Maia, M., Vieira, P., Pina-Vaz, T., Jácome, F., Devezas, V., Almeida, A., Silveira, H., Vaz, S., Castanheira Rodrigues, S., Costa Santos, D., Grilo, J. V., Abreu da Silva, A., Claro, M., Deus, A. C., Branquinho, R., Santos, P. M. D. D., Patrício, B., Vieira Paiva Lopes, A. C., Mendes, J. M., Carvalho, M. F., Oliveira, C. M., Tojal, A., Pinto, J., Abutaka, A., Zarour, A., Abdelkareem, M., Ali, S. M., Al Tarakji, M., Alfkey, R., Mukhtar, K., Wani, I. R., Singh, R., Bouchiba, N., Mahdi, H., Abdelaziem Mustafa, S., Al Ansari, A., Drasovean, R., Caziuc, A., Galliamov, E., Agapov, M., Kakotkin, V., Semina, E., Kubyshkin, V., Kamalov, A., Efetov, S. K., Kochetkov, V. S., Garmanova, T., Tsarkov, P., Tulina, I., Rodimov, S., Markaryan, D., Kazachenko, E., Yanishev, A., Abelevich, A., Bazaev, A., Kokobelyan, A., Zarubenko, P., Zakharenko, A., Novikova, A., Kim, G., Shmatov, D., Stoliarov, M., Kamenskikh, M., Nambi, G., Almulhim, A. S., Madkhali, T., Alzouhir, A., Alissa, A., Alameer, E., Badedi, M., Alnami, A. Q., Darraj, H., Alkhuzaie, A., Khadwardi, F., Abualjadayel, M., Tashkandi, W., Farsi, A., Malibary, N., Trabulsi, N., Farsi, S., Said bayazeed, A., Nasser, M., Siddiqui, M. S., Al Awwad, S., Alshahrani, M., Alsharif, F., Fahmi, M. W., Gudal, A., Alasmari, A., Alqahtani, S., Majrashi, S., Mashat, A., Al Raddadi, R., Alharbi, A., Nasser, Y., Hamayel, H., Alhojaili, A., Aljohani, R., Sogair, O., Alfarhan, O., Alzahrani, A., Alzomaili, B., A Azab, M., Alotaibi, M., Maashi, A., Zowgar, A., Alsakkaf, M., Alnemary, M., Khayat, S., Felmban, S., Almhmadi, A., Alqannas, M., Cortés Guiral, D., Alyami, M., Elawad, A., Alhefdhi, A., Alresaini, F., Kurdi, W., Tulbah, M., Aldakheel, M., Alsahan, N., Koussayer, S., Elsheikh, H., Al-qattan, M., Alshanafey, S., Rafique, A., Mahabbat, N., Saeed, B., Al-Kharashi, E., Alsowaina, K., Arab, N., Aljaber, F., Al Hasan, I., Alghamdi, A., Badahdah, F., Alghuliga, A., Abdulfattah, F., Alanazi, F., Albaqami, F., Alsuhaibani, A., AlFakhri, A., Alqasem, S., Alajaji, N., Nouh, T., Bin Nasser, A., Alowais, J., Alburakan, A., Alamri, O., Albdah, A., Alawi, K., Alshalhoub, M., ElSanhoury, K., Almofarreh, A., Ibrahim, S., Elshafie, H., Osman, I., Guzman, T., Mutair, H., Siddiqui, A., Chowdhury, S., Alghamdi, R., Almutrafi, S., Alfaifi, J., D'Souza, J., Alshitwi, A., Alkreedees, N., Alramadhan, M., Alshehri, M., Alobaysi, S., Alshahrani, A., Alshehri, A., Alrashed, M., Altahan, T., Alsabahi, T., Alhossaini, R., Sbaih, M., Alalawi, Y., Alnwijy, K., Al Ayed, A., Ghedan, S., Alharthi, R., Awad, S., I Sharara, M., Abdelrhman, S., Althobaiti, W., Srbinovic, L., Perovic, M., Mikovic, Z., Nikolic, B., Vasiljevic, M., Pazin, V., Mandic Markovic, V., Dimitrijevic, D., Zecevic, N., Gregoric, P., Micic, D., Loncar, Z., Doklestic, K., Ivancevic, N., Djukic, V., Stojakov, D., Ilic, R., Savic, P., Pijanovic, N., Milanovic, M., Radosavljevic, M., Dejanovic, T., Kostic, M., Paskas, J., Bojic, S., Stevanovic, P., Djuric, M., Kadija, M., Tulic, G., Glisovic Jovanovic, I., Lieske, B., Kayombo, E., Kruger, I., De Kock, M., Malan, A., Ferreira, C., Du Preez, H., Mulder, W., Noel, C., Le Grange, S., Lusawana, O., Kies, C., Steyn, E., Janson, J., Buitendag, J. J. P., Chu, K., Mihalik, M., Nel, R., Naidoo, S., Kloppers, C., Nel, D., Jonas, E., Pickard, H., Bernon, M., Almgla, N., Rayamajhi, S., Mugla, W., Carapinha, C., Hyman, G. Y., Fourtounas, M., Moore, R., Sánchez Mozo, A., Aguado Lopez, H., Zárate Pinedo, A., Jimenez Toscano, M., Alonso de la Fuente, N., Mancebo, G., Cecchini, L., Munarriz, M., Cazador Labat, M., López Campillo, A., Martorell, P., Espinosa, C. A., Caja Vivancos, P., Villalabeitia Ateca, I., Prieto Calvo, M., Marín, H., Martin Playa, P., Gainza, A., Aragon Achig, E. J., Rodriguez Fraga, A., Melchor Corcóstegui, I., Mallabiabarrena Ormaechea, G., Garcia Gutierrez, J. J., Barbier, L., Pesántez Peralta, M. A., Jiménez Jiménez, M., Municio Martín, J. A., Gómez Suárez, J., García Operé, G., Pascua Gómez, L. A., Oñate Aguirre, M., Fernandez-Colorado, A., De la Rosa-Estadella, M., Gasulla-Rodriguez, A., Serrano-Martin, M., Peig-Font, A., Junca-Marti, S., Juarez-Pomes, M., Garrido-Ondono, S., Blasco-Torres, L., Molina-Corbacho, M., Maldonado-Sotoca, Y., Gasset-Teixidor, A., Blasco-Moreu, J., Gomez Fernandez, L., Cayetano Paniagua, L., Izquierdo, O., Ventura, D., Castellanos, J., Ballester Vazquez, E., Sanchez Lopez, A., Balague Ponz, C., Targarona Soler, E. M., Sanchez Cabús, S., Molina Santos, V., Gonzalez Lopez, J. A., Medrano Caviedes, R., Moral Duarte, A., Espin-Basany, E., Pellino, G., Blanco-Colino, R., Turrado-Rodriguez, V., Lacy, A. M., de Lacy, F. B., Morales, X., Carreras-Castañer, A., Torner, P., Jornet-Gibert, M., Balaguer-Castro, M., Renau-Cerrillo, M., Camacho-Carrasco, P., Vives-Barquiel, M., Campuzano-Bitterling, B., Gracia, I., Pujol-Muncunill, R., Martin-Sole, O., Rubio-Palau, J., Tarrado, X., Garcia-Aparicio, L., De Haro Jorge, I., Martin, A., Rojas-Ticona, J., Perez-Bertolez, S., Cuesta Argos, M., Capdevila Vilaro, B., Coronas Soucheiron, M., Riba Martinez, M., Saura Garcia, L., Prat Ortells, J., Bejarano Serrano, M., Parri, P., Massaguer, C., Vicario, F., Palazon Bellver, P., Moraleda Gudayol, I., Lara, A., Escobar, D., Arrieta, M., Garcia de cortazar, U., Villamor Garcia, I., Landaluce-olavarria, A., Gonzalez De miguel, M., Fernández Gómez Cruzado, L., Begoña, E., Lecumberri, D., Acosta Mérida, M. A., Yepes Cano, A. F., Estaire Gómez, M., Padilla-Valverde, D., Sánchez-García, S., Sanchez-Pelaez, D., Jimenez Higuera, E., Picón Rodríguez, R., Fernández Camuñas, À., Martínez-Pinedo, C., Garcia Santos, E. P., Muñoz-Atienza, V., Moreno Pérez, A., López de la Manzanara Cano, C. A., Ugarte-Sierra, B., Ibáñez-Aguirre, F. J., De Andres Olabarria, U., Fernández Pablos, F. J., Durán Ballesteros, M., Sanz Larrainzar, A., Jiménez Carneros, V., Valle Rubio, A., Alonso-Lamberti, L., García-Quijada, J., Leon, R., Rodriguez, J. L., Jimenez Miramón, J., Jover, J. M., Martín Salamanca, M. B., Assaf, M., Pérez Simón, V., Landeo Agüero, S. A., Baeza Pintado, N., Huertas Fernandez, M. A., Carabias, A., Sosa, M. V., Lora-Cumplido, P., Lanuza, L., Galipienso Eri, M., Garcia Montesino, J. D., Dellonder Frigolé, J., Noriego Muñoz, D., Navarro-Sánchez, A., Enjuto, D., Perez Gonzalez, M., Díaz Peña, P., Gonzalez, J., Marqueta De Salas, M., Martinez Pascual, P., Rodríguez Gómez, L., Garcés García, R., Ramos Bonilla, A., Herrera-Merino, N., Fernández Bernabé, P., Cagigal Ortega, E. 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S., Matute-Najarro, M., Herrero-Lopez, M., Sanchez-Rubio, M., Cantalejo-Diaz, M., Gonzalez-Nicolas-Trebol, M. T., Saudi-Moro, S., Jariod-Ferrer, U. M., Rivas, F., Escartin, J., Blas Laina, J. L., Nogués, A., Cros, B., Talal El-Abur, I., Garcia Egea, J., Yanez, C., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S. D., Arulanantham, A., Bandara, G. B. K. D., Hamid, H. K. S., Ali, E. E., Widatalla, A. B. H., Bakheit, I., Awadelkarim, M., Ali karar, A. A., Saleh, M., Taflin, H., Myrelid, P., Amorim Braz, L., Hagander, L., Hambraeus, M., Omling, E., Salö, M., Arkani, S., Freedman, J., Montan, C., Lindqvist, E. K., Elbe, P., Hultgren, R., Älgå, A., Nordberg, M., Sandblom, G., Rutegård, M., Holmner, F., Sund, M., Löfgren, N., Tampakis, A., Kollmar, O., von Fluee, M., Balaphas, A., Toso, C., Colucci, N., Popeskou, S. G., Gass, M., Scheiwiller, A., Metzger, J., Gialamas, E., Chevallay, M., Sauvain, M., Dwidar, O., Kiessling, S. Y., Stoeckli, S. J., Mongelli, F., Bernasconi, M., Di Giuseppe, M., Christoforidis, D., La Regina, D., Arigoni, M., Adamina, M., Peros, G., Guglielmetti, L., Solimene, F., Giardini, M., Bächler, T., Crugnale, A. S., Gutschow, C. A., Turina, M., Ersen, O., Onan, M. A., Kozan, R., Erol, T., Dincer, H. A., Yildiz, A., Iflazoglu, N., Yalkın, O., Isik, A., Ozben, V., Aytac, E., Aliyeva, Z., Akaydin, E., Ozmen, B. B., Baca, B., Altinel, Y., Calikoglu, F., Tokocin, M., Hacim, N. A., Akbas, A., Meric, S., Vartanoglu, T., Yigitbas, H., Ercetin, C., Ercan, G., Ozgur, I., Keskin, M., Saracoglu, K. T., Cimenoglu, B., Demirhan, R., Kale, A., Simsek, T., Gundogdu, E. C., Abbasov, A., Tanal, M., Citgez, B., Bozkurt, E., Yetkin, S. G., Mihmanli, M., Alhamed, A., Ergun, S., Sanli, A. N., Velidedeoglu, M., OZcelik k, M. F., Uludag, S. S., Zengin, A. K., Cebi, S., Demirkiran, F., Bese, T., Acikgoz, A. S., Kayan, B., Aykanat, Y., Mutlu, D., Göksoy, B., Kara, Y., Bozkurt, M. 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B., Geddes, A., McMahon, J., McCaul, J., Al-Azzawi, M., Aitken, E., Glen, P., Sinan, L. O. H., Grivas, A., Tilling, E. J., Brown, O., Boal, M., Dean, H., Higgs, S., Stanger, S., Abdalaziz, H., Constable, J., Ishii, H., Gopi reddy, R., Madhuri, T. K., Tailor, A., Flavin, M., Walker, D., Humphries, S., Assalaarachchi, H., Curl-Roper, T., Westwood, E., Delimpalta, C., Liao, C. C. L., Velchuru, V., Raptis, D. A., Pollok, J. M., Machairas, N., Davidson, B., Fusai, G., Soggiu, F., Xyda, S., Hidalgo Salinas, C., Tzerbinis, H., Pissanou, T., Gilliland, J., Varcada, M., Hart, C., Mirnezami, R., Knowles, J., Angamuthu, N., Vijay, V., Shakir, T., Hasan, R., Tansey, R., Hardie, C., Powell-Smith, E., Kashora, F., Siddique, M. H., Singh, A., Barmpagianni, C., Basgaran, A., Basha, A., Okechukwu, V., Bartsch, A., Gallagher, P., Maqsood, A., Sahnan, K., Leo, C. A., Lewis, S. E., Ubhi, H. K., Exley, R., Khan, U., Shah, P., Saxena, S., Zafar, N., Abdul-Jabar, H., Patel, M., Shabana, A., Alanbuki, A., Usman, O., Ong, C. T., Butterworth, W., Budha Magar, O., El Hadi, M., Abas, S., Annett, J., Ross, E., Loubani, M., Wilkins, A., Cao, H., Capitelli-McMahon, H., Hitchman, L., Ikram, H., Andronic, A., Aboelkassem Ibrahim, A., Totty, J., Blanco, J., Vanker, R., Ghobrial, M., Jones, G., Kanthasamy, S., Fawi, H., Awadallah, M., Chen, F., Cheung, J., Moscalu, A., Bhuvanakrishna, T., Bibby, L., Sinclair, M., Nahid, M. A. K., Williams, L., Basnyat, P. S., Shrestha, A. K., Kumaran, N. K., Sambhwani, S., Sheikh, N. A., Taylor, O. M., Liew, I., Al-Sukaini, A., Mediratta, S., Saxena, D., Sgrò, A., Rashid, M. M., Milne, K., McIntyre, J., Akhtar, M. A., Turnbull, A., Brunt, A., Stewart, K. E., Wilson, M. S. J., Rutherford, D., McGivern, K., Massie, E., Ho, M., Wade, R. G., Johnstone, J., Bourke, G., Brunelli, A., Elkadi, H., Otify, M., Pompili, C., Burke, J. 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A., Collis, J., Warburton, H., Fell, A., Smith, A., Halkias, C., Nikolaou, S., English, C., Kristinsson, S., Oni, T., Ilahi, N., Ballantyne, K., Woodward, Z., Merh, R., Dunning, J., Viswanath, Y., Freystaetter, K., Dixon, J., Hadfield, J. N., Hilley, A., Egglestone, A., Smith, B., Hine, T., Keeler, B., Soulsby, R. E., Taylor, A., Davies, E., Ryska, O., Raymond, T., Rogers, S., Tong, A., Hawkin, P., Tingle, S., Abbadessa, F., Sachdeva, A., Rai, B., Chan, C. D., McPherson, I., Booth, K., Mahmoud Ali, F., Pandanaboyana, S., Grainger, T., Nandhra, S., Patience, A., Roy, C., Williams, T., Dawe, N., McCaffer, C., Riches, J., Bhattacharya, S., Moir, J., Kalson, N. S., Elamin Ahmed, H., Mellor, C., Saleh, C., Koshy, R. M., Hammond, J., Sanderson, L., Wahed, S., Phillips, A. W., Ghosh, K., Tang, A., Beamish, A. J., Price, C., Bosanquet, D., Magowan, D., Solari, F., Williams, G., Nassa, H., Smith, L., Robertson-Smith, B., Mahmoud, A., Ameerally, P., Finch, J. G., Gnanachandran, C., Pop, I., Rogers, M., Yousef, Y., Mohamed, I., Woods, R., Zahid, H., Mundy, G., Sreedharan, L., Baskaran, D., Shaikh, I., Seebah, K., Reid, J., Watts, D., Kouritas, V., Chrastek, D., Maryan, G., Gill, D. F., Khatun, F., Gajjar, K., Williamson, K., Bratt, D., Konstantinidi, K., Walton, T., Burnside, N., Weaver, H., Hawari, M., Addae-Boateng, E., Rollett, R. A., Collins, M. L., Tamimy, M. S., Riyat, H., Wen, J., Neil-Dwyer, J., Brewer, H., Humes, D., Worku, D., Chowdhury, A., Oyende, O., Lewis-Lloyd, C., Adiamah, A., Koh, A., Jackman, J., Vohra, R., Navarro, A., Reilly, J., Aujayeb, A., Townshend, D., McLarty, N., Shenfine, A., Jackson, K., Johnson, C., Dass, D., Ford, D., Winter, S. C., Belcher, E., Stavroulias, D., Di Chiara, F., Wallwork, K., Qureishi, A., Lami, M., Sravanam, S., Mastoridis, S., Shah, K., Chidambaram, S., Smillie, R., Shaw, A. V., Bandyopadhyay, S., Cernei, C., Bretherton, C., Jeyaretna, D., Ganau, M., Piper, R. J., Duck, E., Brown, S., Jelley, C., Tucker, S. C., Bond-Smith, G., Griffin, X. L., Tebala, G. D., Neal, N., Vatish, M., Noton, T. M., Ghattaura, H., Maher, M., Fu, H., Risk, O. B. F., Soleymani majd, H., Sinha, S., Shankar, S., Aggarwal, A., Kharkar, H., Lakhoo, K., Verberne, C., Dean, B., Luney, C., Myatt, R., Williams, M. A., McVeigh, J., Rogers, L. J., Labib, P. L., Miller, D., Minto, G., Hope, N., Marchbank, A., Emslie, K., Panahi, P., Ho, B., Perkins, C., Clough, E., Roy, H., Enemosah, I., Campbell, R., Natale, J., Gohil, K., Rela, M., Raza, N., Biliatis, I., Khan, J., Thiruchandran, G., Toh, S. K. C., Ahmad, Y., Allana, A., Bellis, C., Babawale, O., Phan, Y. C., Lokman, U., Ismail, M., Koc, T., Witek, A., Duggleby, L., Shamoon, S., Stefan, S., Clancy, H., Chadha, R., Middleton, S. 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P., Sureshkumar Shah, N., Sherif, M., Al-mukhtar, A., Whitehall, E., Giblin, A., Sharkey, A., Adamec, A., Madan, S., Narice, B., Sterrenburg, M., Thompson, A., Varley, I., Stavrakas, M., Rominiyi, O., Ray, J., Crank, M., Bacon, A., Al-Tamimi, Y., Catto, J., Saad, S., Abd Kahar, N. N., Sou, A., Simpson, D., Hamilton, E., Blair, J., Jallad, S., Lord, J., Anderson, C., El Kafsi, J., Logishetty, K., Saadya, A., Midha, R., Ip, M., Subbiah Ponniah, H., Stockdale, T., Bacarese-Hamilton, T., Foster, L., James, A., Anjarwalla, N., Marujo Henriques, D., Hettige, R., Baban, C., Tenovici, A., Salerno, G., Lane, J., Colvin, H. V., Badran, A., Cadersa, A., Cumpstey, A., Hamady, Z., Aftab, R., Wensley, F., Byrne, J., Morrison-Jones, V., Sekhon, G. K., Shields, H., Shakoor, Z., Yener, A., Talbot, T., Alzetani, A., Cresner, R., Babu, B. H. B., Liyanage, A. S. D., Newman, S., Blake, I., Weerasinghe, C., Baumber, R., Parry, J., Menakaya, C., Webb, J. 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I., Mallabiabarrena Ormaechea G., Garcia Gutierrez J.J., Barbier L., Pesantez Peralta M.A., Jimenez Jimenez M., Municio Martin J.A., Gomez Suarez J., Garcia Opere G., Pascua Gomez L.A., Onate Aguirre M., Fernandez-Colorado A., De la Rosa-Estadella M., Gasulla-Rodriguez A., Serrano-Martin M., Peig-Font A., Junca-Marti S., Juarez-Pomes M., Garrido-Ondono S., Blasco-Torres L., Molina-Corbacho M., Maldonado-Sotoca Y., Gasset-Teixidor A., Blasco-Moreu J., Gomez Fernandez L., Cayetano Paniagua L., Izquierdo O., Ventura D., Castellanos J., Ballester Vazquez E., Sanchez Lopez A., Balague Ponz C., Targarona Soler E.M., Sanchez Cabus S., Molina Santos V., Gonzalez Lopez J.A., Medrano Caviedes R., Moral Duarte A., Espin-Basany E., Blanco-Colino R., Turrado-Rodriguez V., Lacy A.M., de Lacy F.B., Morales X., Carreras-Castaner A., Torner P., Jornet-Gibert M., Balaguer-Castro M., Renau-Cerrillo M., Camacho-Carrasco P., Vives-Barquiel M., Campuzano-Bitterling B., Gracia I., Pujol-Muncunill R., Martin-Sole O., Rubio-Palau J., Tarrado X., Garcia-Aparicio L., De Haro Jorge I., Martin A., Rojas-Ticona J., Perez-Bertolez S., Cuesta Argos M., Capdevila Vilaro B., Coronas Soucheiron M., Riba Martinez M., Saura Garcia L., Prat Ortells J., Bejarano Serrano M., Parri P., Massaguer C., Vicario F., Palazon Bellver P., Moraleda Gudayol I., Lara A., Escobar D., Arrieta M., Garcia de cortazar U., Villamor Garcia I., Landaluce-olavarria A., Gonzalez De miguel M., Fernandez Gomez Cruzado L., Begona E., Lecumberri D., Acosta Merida M.A., Yepes Cano A.F., Estaire Gomez M., Padilla-Valverde D., Sanchez-Garcia S., Sanchez-Pelaez D., Jimenez Higuera E., Picon Rodriguez R., Fernandez Camunas A., Martinez-Pinedo C., Garcia Santos E.P., Munoz-Atienza V., Moreno Perez A., Lopez de la Manzanara Cano C.A., Ugarte-Sierra B., Ibanez-Aguirre F.J., De Andres Olabarria U., Fernandez Pablos F.J., Duran Ballesteros M., Sanz Larrainzar A., Jimenez Carneros V., Valle Rubio A., Alonso-Lamberti L., Garcia-Quijada J., Leon R., Rodriguez J.L., Jimenez Miramon J., Jover J.M., Martin Salamanca M.B., Assaf M., Perez Simon V., Landeo Aguero S.A., Baeza Pintado N., Huertas Fernandez M.A., Carabias A., Sosa M.V., Lora-Cumplido P., Lanuza L., Galipienso Eri M., Garcia Montesino J.D., Dellonder Frigole J., Noriego Munoz D., Navarro-Sanchez A., Enjuto D., Perez Gonzalez M., Diaz Pena P., Gonzalez J., Marqueta De Salas M., Martinez Pascual P., Rodriguez Gomez L., Garces Garcia R., Ramos Bonilla A., Herrera-Merino N., Fernandez Bernabe P., Cagigal Ortega E.P., Hernandez I., Garcia de Castro Rubio E., Cervera I., Sanchez-Guillen L., Fernandez-Candela A., Curtis-Martinez C., Soler-Silva A., Oller A., Triguero-Canovas D., Bosch-Ramirez M., Lillo C., Lario S., Arroyo A., Espino Segura-Illa M., Sanchez Aniceto G., Castano-Leon A.M., Jimenez-Roldan L., Delgado Fernandez J., Perez Nunez A., Lagares A., Garcia Perez D., Santas M., Paredes I., Esteban Sinovas O., Moreno-Gomez L., Rubio E., Vega V., Vivas Lopez A., 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Gracia M., Siegrist Ridruejo J., Diestro M.D., Sanchez-Mendez J.I., Marti C., Melendez M., Moreno-Palacios E., Loayza A., Frias L., Zapardiel I., Rubio-Perez I., Prieto Nieto M.I., Guevara J., Gegundez Simon A., Gortazar S., Chavarrias N., Alvarez E., Saavedra J., Ramos-Martin P., Urbieta A., Gomez Rivas J., Toribio-Vazquez C., Yebes A., Hernandez-Garcia M., Losada M., Dieguez B., Garcia-Conde M., Alonso Poza A., Marquez L., Becerra R., Martin M., Jorgensen T., Muguerza J.M., Dziakova J., Sanchez del Pueblo C., Saez Carlin P., Camarero E., Picazo S., Pizarro M.J., Avellana R., Catalan V., Lopez Antonanzas L., Cano O., Anula R., Sanz Lopez R., Sanz Ortega G., Garcia Alonso M., Torres A.J., Martin Antona E., Garcia Botella S., Ramos D., Barranquero A.G., Ocana J., Nunez J., Cerro Zaballos C., Crego-Vita D., Huecas-Martinez M., Diez Alonso M., Mendoza-Moreno F., Vera Mansilla C., Ovejero Merino E., Hernandez P., Blazquez Martin A., Ruiz Grande F., Morales Palacios N., Garcia-Loarte Gomez E., Garca Rico E., Minaya-Bravo A.M., San Miguel Mendez C., Galvan Perez A., Gonzalez-Gonzalez E., Robin Valle de Lersundi A., Calcerrada Alises E., Garcia-Urena M.A., Cruz Cidoncha A., Troncoso Pereira P., Alcaide Matas F., Garcia Perez J.M., Munoz Vives J.M., Osorio A., Gomez Diaz C.J., Guariglia C.A., Soto Montesinos C., Sanchon L., Xicola Martinez M., Guardia N., Collera P., Diaz Del Gobbo R., Sanchez Jimenez R., Farre Font R., Flores Clotet R., Calvo Espino P., Guillamot Ruano P., Rey-Biel J., Pingarron-Martin L., Ruiz Martin I., Moliner Sanchez C., Carrasco-Prats M., Gimenez-Frances C., Ruiz-Marin M., Fernandez-Lopez A.J., Garcia-Escudero D., Garcia-Porcel V., Lax-Perez R., Sanchez-Robles M., Valero-Soriano M., Medina-Manuel E., Garcia-Soria V., Gurrea-Almela E., Marco-Garrido A., Martinez-Alonso J.A., Gonzalez-Valverde F.M., Fernandez-Fernandez P.V., Sanchez- Rodriguez C., Aguilar-Jimenez J., Baeza-Murcia M., Aguayo-Albasini J.L., Nicolas-Lopez T., Alconchel F., Fernandez 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Uludag S.S., Zengin A.K., Cebi S., Demirkiran F., Bese T., Acikgoz A.S., Kayan B., Aykanat Y., Mutlu D., Goksoy B., Kara Y., Bozkurt M.A., Kocatas A., Ogucu H., Uslu G., Arican C., Tugmen C., Aydin C., Yesilyurt D., Avci E.K., Kebapci E., Kilinc G., Sert I., Tuncer K., Akalin M., Emiroglu M., Demirli Atici S., Salimoglu S., Kaya T., Kirmizi Y., Tatar O.C., Yuksel E., Guler S.A., Yildirim A., Utkan N.Z., Gozal K., Koken H., Yabas A., Gonullu E., Altintoprak F., Akin E., Kamburoglu B., Capoglu R., Kucuk F., Demir H., Cakmak G., Firat N., Celebi F., Kocer B., Mantoglu B., Bayhan Z., Dikicier E., Colak E., Kucuk G.O., Karaman E., Kolusab A., Karaaslan O., Majid I., Abbas F., Abbas F.M.A., Mohammed D., Tahlak M.A., Yammahi A., Albaroudi A.A., Elyafawi B., Saber A., Khansaheb H., Alsaadi H., Alzarooni N., Bekheit M., Kamera B.S., Elhusseini M., Sharma P., Ahmeidat A., Cymes W., Hannah A., Mignot G., Shaikh S., Agilinko J., Angelou D., Neely D., McCanny A., McAree B., Baldwin A.J., West R., Gammeri E., Catton A., Marinos Kouris S., Pereca J., Singh J., Seymour Z., Jones R., Leeson S., Peevor R., Lala A.K., Houlden C., Kahiu J., Hossain N., Hosny S., Patel P., Handa S., Kaushal M., Kler A., Reghuram V., Tezas S., Fairhurst K., Yates C., Mitchell S., Bunni J., Richards S., George R., Lee S.M., Phull J., Frost J., Burnard S., Crowley R., Airey A., Bevan K., Makin-Taylor R., Ong C.S., Callan R., Bloom O., Aljanadi F., Moawad N., Jones M., Gregg A., Jeganathan R., Pachl M., Martin B., Archer J.E., Odeh A., Siddaiah N., Singhal R., Naumann D.N., Karandikar S., Syed A., Tucker O.N., Alam R., Kalkat M., Mak J.K.C., Kulkarni R., Sharma N., Nankivell P., Tirotta F., Parente A., Breik O., Kisiel A., Cato L.D., Saeed S., Pathanki A.M., Almond M., Kamal M., Leung E.Y.L., Kaur R., Brett-Miller C., Buruiana F.E., Markose G., De Gea Rico A., Taib A., Myatt D., Sulaiman Khaled A., Younis F., Sultana A., Taggarsi M., Vitone L., Lambert J., Vaz O.P., Sarantitis I., Shrestha D., Timbrell S., 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Dean H., Higgs S., Stanger S., Abdalaziz H., Constable J., Ishii H., Gopi reddy R., Madhuri T.K., Tailor A., Flavin M., Walker D., Humphries S., Assalaarachchi H., Curl-Roper T., Westwood E., Delimpalta C., Liao C.C.L., Velchuru V., Raptis D.A., Pollok J.M., Machairas N., Davidson B., Fusai G., Soggiu F., Xyda S., Hidalgo Salinas C., Tzerbinis H., Pissanou T., Gilliland J., Varcada M., Hart C., Mirnezami R., Knowles J., Angamuthu N., Vijay V., Shakir T., Hasan R., Tansey R., Hardie C., Powell-Smith E., Kashora F., Siddique M.H., Singh A., Barmpagianni C., Basgaran A., Basha A., Okechukwu V., Bartsch A., Gallagher P., Maqsood A., Sahnan K., Leo C.A., Lewis S.E., Ubhi H.K., Exley R., Khan U., Shah P., Saxena S., Zafar N., Abdul-Jabar H., Patel M., Shabana A., Alanbuki A., Usman O., Ong C.T., Butterworth W., Budha Magar O., El Hadi M., Abas S., Annett J., Ross E., Loubani M., Wilkins A., Cao H., Capitelli-McMahon H., Hitchman L., Ikram H., Andronic A., Aboelkassem Ibrahim A., Totty J., Blanco J., Vanker R., Ghobrial M., Jones G., Kanthasamy S., Fawi H., Awadallah M., Chen F., Cheung J., Moscalu A., Bhuvanakrishna T., Bibby L., Sinclair M., Nahid M.A.K., Williams L., Basnyat P.S., Shrestha A.K., Kumaran N.K., Sambhwani S., Sheikh N.A., Taylor O.M., Liew I., Al-Sukaini A., Mediratta S., Saxena D., Sgro A., Rashid M.M., Milne K., McIntyre J., Akhtar M.A., Turnbull A., Brunt A., Stewart K.E., Wilson M.S.J., Rutherford D., McGivern K., Massie E., Ho M., Wade R.G., Johnstone J., Bourke G., Brunelli A., Elkadi H., Otify M., Pompili C., Burke J.R., Bagouri E., Chowdhury M., Abual-Rub Z., Kaufmann A., Munot S., Lo T., Young A., Kowal M., Wall J., Peckham-Cooper A., Layton G.R., Karki B., Jeong H., Pankhania S., Asher S., Folorunso A., Mistry S., Singh B., Winyard J., Mangwani J., Mohammad A., Acharya M., Chandarana K., Ang K., Chowdhry M.F., Rathinam S., Nakas A., Boddy A., Hossain T., Ashmore C., Annamalai S., Kourdouli A., Irvine E., Al-Harbawi A., Kassam K., Al-Harbawee A., Miller A., Mair M., Lunevicius R., Sheel A.R.G., Sundhu M., Santini A.J.A., Fathelbab M.S.A.T., Hussein K.M.A., Nunes Q.M., Jones R.P., Shahzad K., Haq I., Baig M.M.A.S., Hughes J.L., Kattakayam A., Rajput K., Misra N., Shah S.B., Clynch A.L., Georgopoulou N., Sharples H.M., Apampa A.A., Nzenwa I.C., Sud A., Harky A., Kirmani B.H., Shackcloth M., Zakaria R., Elmoslemany T., Millward C.P., Baron R., Dunne D., Szatmary P., Thomas A., McNicol F., Gahunia S., Sochorova D., Nita G.E., McKinney R., Russ J., Tan J.R., Harwood R., Corbett H.J., Rossborough C., Skelly B.L., Che Bakri N.A., Nazarian S., Vashisht R., Jiao L., Jawad Z., Allan A.Y., Kontovounisios C., Grove T., Warren O., Fadel M.G., Chatzikonstantinou M., Sorelli P., Rahman S., Hadjipavlou M., Holbrook C., Chong C., Kufeji D., Rufai S.R., Lloyd I.C., James G., Chari A., Silva A.H.D., Stroman L., Challacombe B., Sayasneh A., Najdy M., Bille A., Fraser S., Agoston P., Rizzo V., King J., Nath R., McCrindle S., Mehra G., 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M.A., Jayasinghe J.D., Leal Silva I., Thakur B., Lebe M., Thet M.S., Hughes F., Rahman R., Fuwa O., Oo A., Bueser T., Curtis M., Stamenkovic S.A., Abbott T., Anwar S., Williams K., Chung E., Hagger R., Karim A., Hainsworth A., Flatman M., Trompeter A., Hing C., Tsinaslanidis P., Benjamin M.W., Leyte A., Tan C., Smelt J., Vaughan P., Santhirakumaran G., Hunt I., Raza M., Labib A., Luo X., Sudarsanam A., Rolls A., Lyons O., Onida S., Shalhoub J., Sugand K., Park C., Sarraf K.M., Erridge S., Kinross J., Denning M., Yalamanchili S., Abuown A., Ibrahim M., Martin G., Davenport D., Wheatstone S., Kasivisvanathan V., Kapriniotis K., Elhamshary A., Imam S.M.B., Kalavrezos N., Sinha D., Chand M., Green L., Beech N., McEwen R., Kiconco H., Andreani S.M., Bath M.F., Sahni A., Judkins N., Rigueros Springford L., Bacarese-Hamilton J., Taylor F.G., Parmar C., Mccluney S., Shah S., Talwar R., Patel K., Askari A., Jambulingam P.S., Shaw S., Maity A., Hatzantonis C., Sagar J., Kudchadkar S., Cirocchi N., Chan C.H., Reynolds J., Alexander M.E., Smart C.J., Jayasankar B., Balasubramaniam D., Abdelsaid K., Mundkur N., Gallagher B., Shah J., Anthoney J., Emmerson O., Stylianides N., Abdalla M., Newton K., Bhatia K., Edmondson R., Abdeh L., Jones D., Zeiton M., Ismail O., Naseem H., Advani R., Duff S., Moura F., Brown B.C., Khan A., Asaad P., Wadham B., Aneke I.A., Collis J., Warburton H., Fell A., Smith A., Halkias C., Nikolaou S., English C., Kristinsson S., Oni T., Ilahi N., Ballantyne K., Woodward Z., Merh R., Dunning J., Viswanath Y., Freystaetter K., Dixon J., Hadfield J.N., Hilley A., Egglestone A., Smith B., Hine T., Keeler B., Soulsby R.E., Taylor A., Davies E., Ryska O., Raymond T., Rogers S., Tong A., Hawkin P., Tingle S., Abbadessa F., Sachdeva A., Rai B., Chan C.D., McPherson I., Booth K., Mahmoud Ali F., Pandanaboyana S., Grainger T., Nandhra S., Patience A., Roy C., Williams T., Dawe N., McCaffer C., Riches J., Bhattacharya S., Moir J., Kalson N.S., Elamin Ahmed H., Mellor C., Saleh C., Koshy R.M., Hammond J., Sanderson L., Wahed S., Phillips A.W., Ghosh K., Tang A., Beamish A.J., Price C., Bosanquet D., Magowan D., Solari F., Williams G., Nassa H., Smith L., Robertson-Smith B., Mahmoud A., Ameerally P., Finch J.G., Gnanachandran C., Pop I., Rogers M., Yousef Y., Mohamed I., Woods R., Zahid H., Mundy G., Sreedharan L., Baskaran D., Shaikh I., Seebah K., Reid J., Watts D., Kouritas V., Chrastek D., Maryan G., Gill D.F., Khatun F., Gajjar K., Williamson K., Bratt D., Konstantinidi K., Walton T., Burnside N., Weaver H., Hawari M., Addae-Boateng E., Rollett R.A., Collins M.L., Tamimy M.S., Riyat H., Wen J., Neil-Dwyer J., Brewer H., Humes D., Worku D., Chowdhury A., Oyende O., Lewis-Lloyd C., Adiamah A., Koh A., Jackman J., Vohra R., Navarro A., Reilly J., Aujayeb A., Townshend D., McLarty N., Shenfine A., Jackson K., Johnson C., Dass D., Ford D., Winter S.C., Belcher E., Stavroulias D., Di Chiara F., Wallwork K., Qureishi A., Lami M., Sravanam S., Mastoridis S., Shah K., Chidambaram S., Smillie R., Shaw A.V., Bandyopadhyay S., Cernei C., Bretherton C., Jeyaretna D., Ganau M., Piper R.J., Duck E., Brown S., Jelley C., Tucker S.C., Bond-Smith G., Griffin X.L., Tebala G.D., Neal N., Vatish M., Noton T.M., Ghattaura H., Maher M., Fu H., Risk O.B.F., Soleymani majd H., Sinha S., Shankar S., Aggarwal A., Kharkar H., Lakhoo K., Verberne C., Dean B., Luney C., Myatt R., Williams M.A., McVeigh J., Labib P.L., Miller D., Minto G., Hope N., Marchbank A., Emslie K., Panahi P., Ho B., Perkins C., Clough E., Roy H., Enemosah I., Campbell R., Natale J., Gohil K., Rela M., Raza N., Biliatis I., Khan J., Thiruchandran G., Toh S.K.C., Ahmad Y., Allana A., Bellis C., Babawale O., Phan Y.C., Lokman U., Ismail M., Koc T., Witek A., Duggleby L., Shamoon S., Stefan S., Clancy H., Chadha R., Middleton S.B., Wilmott K., Hayden C., Mclaren C., Sutton J., Whyte A., Belgaumkar A., Day A., Gilbert C., Oyewole B., Narayan P., Dent H., Sandhya A., De Silva T., Waheed S., Kapoor K., Belgaumkar A.P., Fahim M., Gala T., Mithany R., Morgan R., Abdelkarim M., Maw A., Asqalan A., Sundaram Venkatesan G., Singh S., Mukherjee S., Ferguson D., Mansuri A., Thakrar A., Wickramarachchi L., Cuthbert R., Sivayoganathan S., Chui K., Karam E., Dott C., Madhvani K., Hampton M., Hormis A.P., Fountain D.M., Laurente R., Sigamoney K.V., Dasa M., George K., Naqui Z., Galhoum M., Lipede C., Gabr A., Radhakrishnan A., Hasan M.T., Kalenderov R., Pathmanaban O., Chelva R., Branagan G., Longstaff L., Ding D., Barlow C., Foster J., Ward A., Tadross D., Majkowski L., Blundell C., Nair R., Guha S., Brown S.R., Steele C., Kelty C.J., Newman T., Lee M., Lye G., Balasubramanian S.P., Sureshkumar Shah N., Sherif M., Al-mukhtar A., Whitehall E., Giblin A., Sharkey A., Adamec A., Madan S., Narice B., Sterrenburg M., Thompson A., Varley I., Stavrakas M., Rominiyi O., Ray J., Crank M., Bacon A., Al-Tamimi Y., Catto J., Saad S., Abd Kahar N.N., Sou A., Simpson D., Hamilton E., Blair J., Jallad S., Lord J., Anderson C., El Kafsi J., Logishetty K., Saadya A., Midha R., Ip M., Subbiah Ponniah H., Stockdale T., Bacarese-Hamilton T., Foster L., James A., Anjarwalla N., Marujo Henriques D., Hettige R., Baban C., Tenovici A., Salerno G., Lane J., Colvin H.V., Badran A., Cadersa A., Cumpstey A., Hamady Z., Aftab R., Wensley F., Byrne J., Morrison-Jones V., Sekhon G.K., Shields H., Shakoor Z., Yener A., Talbot T., Alzetani A., Cresner R., Babu B.H.B., Liyanage A.S.D., Newman S., Blake I., Weerasinghe C., Baumber R., Parry J., Menakaya C., Webb J.I., Antar M., Modi N., Sofat R., Noel J., Nunn R., Adegbola S., Eriberto F., Sharma V., Tanna R., Lodhia S., Johnson D., Hughes I., Hall J., Rooney J., Chatterji S., Zhang Y., Owen R., Rudic M., Hunt J., Zakai D., Aladeojebi A., Ali M., Gaunt A., Barmayehvar B., Kitchen M., Gowda M., Mansour F., Jarvis M., Halliday E., Lefroy R., Nanjaiah P., Lin D.J., Rajgor A.D., Scurrah R.J., Kang C., Watson L.J., Harris G., Royle T., Cunningham Y., Steel B., Luk A.C.O., Boulton A.J., Bakolas G., Herrod P., Gemmill E., Boyd-Carson H., Jibreel M., Lenzi E., Saafan T., Sapre D., Li Z., Parkins K., Spencer N., Harries R., Egan R.J., Motter D., Jenvey C., Mahoney R., Fine N., Minto T., Henry A., Hollyman M., Grieco C., Gemmell C., Whitmore H., Babar M.S., Goodrum S., Scott R., Collard B., Lau K., Thomas E., Patel A., Allison J., Bowen J., Dias A., Mahendran B., Gopalswamy S., Patil S., Scott L., Sarveswaran J., Michel M., Ravindran S., Subba K., Abou-Foul A.K., Khalefa M., Hossain F., Moores T., Pickering L., Stables G., Doorgakant A., Thiruvasagam V.G., Carter J., Reid S., Mohammed R., Marlow W., Ferguson H., Wilkin R., Konstantinou C., Yershov D., Vatish J., Denning A., Shah H.B., Cross G.W.V., Seyed-Safi P., Smart Y.W., Kuc A., Al-Yaseen M., Olivier J., Hanna M., Eskander P., Duncan R., Halaseh S., Das R., Wynn Jones H., Divecha H., Whelton C., Board T., Powell S., Magee C., Agarwal K., Mangos E., Nambirajan T., Vidya R., Chauhan G., Kaur J., Burahee A., Bleibleh S., Pigadas N., Snee D., Bhasin S., Crichton A., Habeebullah A., Bodla A.S., Yassin N., Mondragon M., Dewan V., Flindall I., Mahendran V., Hanson A., Jenner E., Richards J., Thomas-Fernandez K., Wall R., Alqallaf A., Ben-Sassi A., Mellor K., Joshi P., Joshi Y., Young R., Miu V., Sheridan K., MacDonald L., Green S., Onos L., Wong J.J., Napolitano L., Hemmila M., Amin D., Abramowicz S., Roser S.M., Olson K.A., Riley C., Heron C., Cardenas T., Leede E., Thornhill M., Haynes A.B., McElhinney K., Roward S., Trust M.D., Hill C.E., Teixeira P.G., Etchill E., Stevens K., Ladd M.R., Long C., Rose J., Kent A., Yesantharao P., Vervoort D., Jenny H., Gabre-Kidan A., Margalit A., Tsai L., Malapati H., Yesantharao L., Abdou H., Diaz J., Richmond M., Clark J., O'Meara L., Hanna N., Ying Y., Fleming J., Ovaitt A., Gigliotti J., Fuson A., Cooper Z., Salim A., Hirji S.A., Chung C., Hansen L., Okafor B.U., Roxo V., Raut C.P., Jolissaint J.S., Mahvi D.A., Bankhead-Kendall B., Velmahos G., Maurer L.R., El Moheb M., Gaitanidis A., Naar L., Christensen M.A., Kapoen C., Langeveld K., El Hechi M., Mokhtari A., Haqqani M.H., Drake F.T., Goldenberg-Sandau A., Galbreath B., Reinke C., Ross S., Thompson K., Manning D., Perkins R., Eriksson E., Evans H., Masrur M., Giulianotti P., Benedetti E., Chang G., Ourieff J., Dehart D., Dorafshar A., Price T., Bhama A.R., Torquati A., Cherullo E., Kennedy R., Myers J., Rubin K., Ban V.S., Aoun S.G., Batjer H.H., Caruso J., Carmichael H., Velopulos C.G., Wright F.L., Urban S., McIntyre R.C., Schroeppel T.J., Hennessy E.A., Dunn J., Zier L., Burlew C., Coleman J., Colling K.P., Hall B., Rice H.E., Hwang E.S., Olson S.A., Moris D., Verma R., Hassan R., Volpe A., Merola S., O'Banion L.A., Lilienstein J., Dirks R., Marwan H., Almasri M., Kulkarni G., Mehdi M., Abouassi A., Abdallah M., San Andres M., Eid J., Aigbivbalu E., Sundaresan J., George B., Ssentongo A., Ssentongo P., Oh J.S., Hazelton J., Maines J., Gusani N., Garner M., Horvath S., Zheng F., Ujiki M., Kinnaman G., Meagher A., Sharma I., Holler E., McKenzie K., Chan J., Fretwell K., Nugent W., Khalil A., Chen D., Post N., Rostkowski T., Brahmbhatt D., Huynh K., Hibbard M.L., Schellenberg M., Martin R.C.G., Bhutiani N., Giorgakis E., Laryea J., Bhavaraju A., Sexton K., Kost M., Kimbrough M., Burdine L., Kalkwarf K., Robertson R., Gosain A., Camp L., Lewit R., Kronenfeld J.P., Urrechaga E., Goel N., Rattan R., Hart V., Gilna G., Cioci A., Ruiz G., Rakoczy K., Pavlis W., Saberi R., Morris R., Karam B.S., Brathwaite C.E.M., Liu H., Petrone P., Hakmi H., Sohail A.H., Baltazar G., Heckburn R., Nygaard R.M., Colonna E.T., Endorf F.W., Hill M.J., Maiga A., Dennis B., Levin J.H., Lallemand M., Choron R., Peck G., Soliman F., Rehman S., Glass N., Juthani B., Deisher D., Ruzgar N.M., Ullrich S.J., Sion M., Paranjape C., Kar A.R., Gillezeau C., Rapp J., Taioli E., Miles B.A., Alpert N., Podolsky D., Coleman N.L., Callahan M.P., Brown L., Monson J.R.T., Dehal A., Abbas A., Soliman A., Kim B., Jones C Dauer M.D.E., Renza-Stingone E., Hernandez E., Gokcen E., Kropf E., Sufrin H., Hirsch H., Ross H., Engel J., Sewards J., Poggio J., Sanserino K., Rae L., Philp M., Metro M., McNelis P., Petrov R., Pazionis T., Till B., Lamm R., Rios-Diaz A.J., Palazzo F., Rosengart M., Nicholson K., Carrick M.M., Rodkey K., Suri A., Callcut R., Nicholson S., Talathoti N., Klaristenfeld D., Biffl W., Marsh C., Schaffer K., Berndtson A.E., Averbach S., Curry T., Kwan-Feinberg R., Consorti E., Gonzalez R., Grolman R., Liu T., Merzlikin O., Abel M.K., Ozgediz D., Boeck M., Kornblith L.Z., Nunez-Garcia B., Robinson B., Park P., Utria A.F., Rice-Townsend S.E., Javid P., Hauptman J., Kieran K., Nehra D., Walters A., Cuschieri J., Davidson G.H., Cosker R., Eckhouse S., Choudhry A., Marx W., Jamil T., Seegert S., Al-Embideen S., Quintana M., Jackson H., Wexner S.D., Kent I., Martins P.N., Alshehari M., Al-Naggar H., Alsayadi M., Alyazidi M., Shream S., Alhaddad W., Maqus A., Abu Hamra'a M., Alsayadi R., Ghannam R., Al-Maqtari S., Masdoos S., Al-Harazi Y., Bajjah H., Al-ameri S., Aldawbali M., Gwini G.P., Collaborative, Cardiothoracic Interdisciplinary Research Network and COVIDSurg, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The Cardiothoracic Interdisciplinary Research Network and COVIDSurg Collaborative, Akowuah, E, Benson, R, Caruana, E, Chetty, G, Edwards, J, Forlani, S, Gradinariu, G, Murphy, G, Oo, A, Patel, A, Ridley, B, Rogers, L, Sanders, J, Tyson, N, Vaja, R, Siaw-Acheampong, K, Argus, L, Chaudhry, D, Dawson, B, Glasbey, J, Gujjuri, R, Jones, C, Kamarajah, S, Khatri, C, Keatley, J, Lawday, S, Li, E, Mann, H, Marson, E, Mclean, K, Picciochi, M, Taylor, E, Tiwari, A, Simoes, J, Trout, I, Venn, M, Wilkin, R, Bhangu, A, Nepogodiev, D, Dajti, I, Gjata, A, Boccalatte, L, Modolo, M, Cox, D, Pockney, P, Townend, P, Aigner, F, Kronberger, I, Hossain, K, Vanramshorst, G, Lawani, I, Ataide, G, Baiocchi, G, Buarque, I, Gohar, M, Slavchev, M, Agarwal, A, Brar, A, Martin, J, Olivos, M, Calvache, J, Perez Rivera, C, Hadzibegovic, A, Kopjar, T, Mihanovic, J, Klat, J, Novysedlak, R, Christensen, P, El-Hussuna, A, Batista, S, Lincango, E, Emile, S, Mengesha, M, Hailu, D, Tamiru, H, Kauppila, J, Laukkarinen, J, Arnaud, A, Albertsmeiers, M, Lederhuber, H, Loffler, M, Tabiri, S, Metallidis, S, Tsoulfas, G, Lorena, M, Grecinos, G, Mersich, T, Wettstein, D, Ghosh, D, Kembuan, G, Brouk, P, Khosravi, M, Mozafari, M, Adil, A, Mohan, H, Zmora, O, Fiore, M, Gallo, G, Pata, F, Pellino, G, Satoi, S, Ayasra, F, Chaar, M, Fakhradiyev, I, Jamal, M, 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Gjata, Arben, Boccalatte, Lui, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohane, Hailu, Dr.Samuel, Tamiru, Hailu, Kauppila, Joona, Laukkarinen, Johanna, Arnaud, Alexi, Albertsmeiers, Marku, Lederhuber, Han, Loffler, Marku, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgio, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tama, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Fari, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moise, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andrea, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelo, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Denni, Simoes, Joana F.F., Dajti, I., Valenzuela, J.I., Boccalatte, L.A., Gemelli, N.A., Smith, D.E., Dudi-Venkata, N.N., Kroon, H.M., Sammour, T., Roberts, M., Mitchell, D., Lah, K., Pearce, A., Morton, A., Dawson, A.C., Drane, A., Sharpin, C., Nataraja, R.M., Pacilli, M., Cox, D.R.A., Muralidharan, V., Riddiough, G.E., Clarke, E.M., Jamel, W., Qin, K.R., Pockney, P., Cope, D., Egoroff, N., Lott, N., Putnis, S., De Robles, S., Ang, Z., Mitteregger, M., Uranitsch, S., Stiegler, M., Seitinger, G., Aigner, F., Lumenta, D.B., Nischwitz, S.P., Richtig, E., Pau, M., Srekl-Filzmaier, P., Eibinger, N., Michelitsch, B., Fediuk, M., Papinutti, A., Seidel, G., Kahn, J., Cohnert, T.U., Messner, F., Öfner, D., Presl, J., Varga, M., Weitzendorfer, M., Emmanuel, K., Binder, A.D., Zimmermann, M., Holawe, S., Nkenke, E., Grimm, C., Kranawetter, M., Rahman Mitul, A., Islam, N., Karim, S., Komen, N., Ang, E., De Praetere, H., Tollens, T., Schols, G., Smets, C., Haenen, L., Quintens, J., Van Belle, K., Van Ramshorst, G.H., Pattyn, P., Desender, L., Martens, T., Van de putte, D., Lerut, P., Grimonprez, A., Janssen, M., De Smul, G., Wallaert, P., Van den Eynde, J., Oosterlinck, W., Van den Eynde, R., Sermon, A., Boeckxstaens, A., Cordonnier, A., De Coster, J., Jaekers, J., Politis, C., Miserez, M., Duchateau, N., De Gheldere, C., Flamey, N., Christiano, A., Guidi, B., Minussi, A.L., Castro, S., Okoba, W., Maldonado, F.H.R., Oliveira, P., Baldasso, T., Santos, L., Gomes, G.M.A., Buarque, I.L., Pol-Fachin, L., Bezerra, T.S., Barros, A.V., da Silva, A.M.R., Leite, A.L.S., Silvestre, D.W.A., Ferro, C.C., Araujo, M.S., Lopes, L.M., Damasceno, P.D., Araujo, D.H.S., Laporte, G., Salem, M.C., Guimaraes-Filho, M.A.C., Nacif, L., Flumignan, R.L.G., Nakano, L.C.U., Kuramoto, D.A.B., Aidar, A.L.S., Pereda, M.R., Correia, R.M., Santos, B.C., Carvalho, A.A., Amorim, J.E., Guedes Neto, H.J., Areias, L.L., Sousa, A.F., Flumignan, C.D.Q., Lustre, W.G., Moreno, D.H., Barros, N., Baptista-Silva, J.C.C., Matos, L.L., Kowaski, L.P., Kulcsar, M.A.V., Nunes, K.S., Teixeira, M.F., Nunes, R.L., Ijichi, T.R., Kim, N.J., Marreiro, A., Muller, B., Barakat Awada, J., Baiocchi, G., Kowalski, L.P., Vartanian, J.G., Makdissi, F.B., Aguiar, S., Marques, N., Carvalho, G.B., Marques, T.M.D.M., Abdallah, E.A., Zurstrassen, C.E., Gross, J.L., Zequi, S.C., Gonçalves, B.T., Santos, S.S., Duprat, J.P., Coimbra, F.J.F., Cicco, R., Takeda, F., Cecconello, I., Ribeiro, U., Gatti, A., Oliva, R., Nardi, C., Slavchev, M., Atanasov, B., Belev, N., Dell, A., Bigam, D., Dajani, K., Al Riyami, S., Martin, J., Cheng, D., Yang, H., Fayad, A., Carrier, F.M., Amzallag, E., Desroches, J., Ruel, M., Caminsky, N.G., Boutros, M., Moon, J., Wong, E.G., Vanounou, T., Pelletier, J., Wong, S., Girsowicz, E., Bayne, J., Obrand, D., Gill, H., Steinmetz, O., MacKenzie, K., Lukaszewski, M., Jamjoum, G., Richebé, P., Verdonck, O., Discepola, S., Godin, N., Idrissi, M., Briatico, D., Sharma, S., Talwar, G., Bailey, K., Lecluyse, V., Côté, G., Demyttenaere, S., Garfinkle, R., Kouyoumdjian, A., Dumitra, S., Khwaja, K., Luo, L., Berry, G., Liberman, A.S., Schmid, S., Spicer, J., Al Farsi, M., Abou-Khalil, J., Couture, E., Mohammadi, S., Tremblay, H., Gagné, N., Bergeron, A., Turgeon, Af, Costerousse, O., Bellemare, D., Babin, C., Blier, C., Wood, M.L., Persad, A., Groot, G., Pham, H., D'Aragon, F., Carbonneau, E., Bouchard, M., Masse, M., Pesant, F., Héroux, J., Karanicolas, P., Hallet, J., Nadler, A., Nathens, A., Ko, M., Brar, A., Mayson, K., Kidane, B., Srinathan, S., Escudero, M.I., Reyes, J.T., Modolo, M.M., Ramirez Nieto, P., Sepulveda, R., Bolbarán, A., Molero, A., Ruiz, I., Reyes, G.P., Salas, R., Suazo, C., Muñoz, R., Grasset, E., Inzunza, M., Besser, N., Irarrázaval, M.J., Jarry, C., Bellolio, F., Romero Manqui, C.A., Ruiz Esquide, M., Fuentes, T., Campos, J., Perez Rivera, C.J., Cabrera, P.A., Pinilla, R.E., Guevara, O., Jimenez Ramirez, L.J., Velasquez Cuasquen, B.G., Herrera Mora, D.R., Bonilla, A., Diaz, S., Manrique, E., Facundo, H., Velez Bernal, J.L., Ángel, J., García, M., Guzmán, L., Lehmann, C., Cervera, S., Trujillo Sanchez, L.M., Guevara, R., Valbuena, D., Suarez, L., Jimenez, G., Velandia, A., Vargas, J., Espinosa, J., Rey, S., Mendoza Quevedo, Jairo, Calvache, J.A., Orozco-Chamorro, C.M., Sánchez-Gómez, T.A., Rojas-Tejada, D.A., Mihanovic, J., Bakmaz, B., Rakvin, I., Sulen, N., Andabaka, T., Luksic, I., Mamic, M., Martinek, L., Skrovina, M., Žatecký, J., Peteja, M., Kristensen, H.Ø., Mekhael, M., Christensen, P., Westh, L., Smith, H., Haugstvedt, A.F., Jönsson, M.L., Crespo, A., Batista, S., Rodriguez-Abreu, J., Tactuk, N., Diaz-Delgado, P.J., Rivas, R., Sarmiento-Bobadilla, J.A., Ashoush, F., Samir Abdelaal, A., Qatora, M.S., Elsayed Hewalla, M.E., Metwalli, M., Atta, R., Abdelmajeed, A., Abosamak, N.E., Sabry, A., Shehata, S., Sallam, I., Amira, G., Sherief, M., Sherif, A., Salem, H., Hamdy, R., Aboulkassem, H., Ghaly, G., Sherif, G., Morsi, A., Abdelrahman, A., Omnia, Ahmed, Tawheed, A., El Kassas, M., Omar, W., Abdelsamed, A., Seleim, A., Azzam, A.Y., ElFiky, M., Nabil, A., Ibraheem, M., ELDeeb, M., Fawzy, M., Hamed, H., Emile, S., Elfallal, A., Elfeki, H., Shalaby, M., Sakr, A., Alrahawy, M., Atif, H., Soltan, H., Sayed, A.K., Salah, A., Atiya, A., Wassim, K., Abbas, A.M., Abd Elazeem, H.A.S., Abd-Elkariem, A.Y., Abd-Elkarem, M.M., Alaa, S., Ali, A.K., Ashraf, M., Ayman, A., Azizeldine, M.G., Elkhayat, H., Emad Mashhour, A., Gaber, M., Hamza, H.M., Hawal, I., Hetta, H.F., Elghazaly, S.M., Mohammed, M.M., Monib, F.A., Nageh, M.A., Saad, A., Saad, M.M., Shahine, M., Yousof, E.A., Youssef, A., Esmail, E., Khalaf, M., Eldaly, A., Ghoneim, A., Hawila, A., Badr, H., Elhalaby, I., Abdel-bari, M., Elbahnasawy, M., Hamada, M.K., Morsy, M.S., Hammad, M., Essa, M., Fayed, M.T., Elzoghby, M., Rady, M., Hamad, O., Salman, S., Sarsik, S., Abd-elsalam, S., Gamal Badr, S., El-Masry, Y., Moahmmed, M.M.H., Hailu, S., Wolde, A., Mengesha, M., Nida, S., Workneh, M., Y Ahmed, M., Fisseha, T., Kassa, D., Zeleke, H., Admasu, A., Laeke, T., Tirsit, A., Gessesse, M., Addissie, A., Bekele, D., Kauppila, J.H., Sarjanoja, E., Testelin, S., Dakpé, S., Devauchelle, B., Bettoni, J., Lavagen, N., Schmitt, F., Lemée, J.M., Boucher, S., Breheret, R., Kün-Darbois, J.D., Kahn, A., Gueutier, A., Bigot, P., Borraccino, B., Lakkis, Z., Doussot, A., Heyd, B., Manfredelli, S., Mathieu, P., Paquette, B., Turco, C., Barrabe, A., Louvrier, A., Moszkowicz, D., Giovinazzo, D., Bretagnol, F., Police, A., Charre, L., Volpin, E., Braham, H., El Arbi, N., Villefranque, V., Bendjemar, L., Girard, E., Abba, J., Trilling, B., Chebaro, A., Lecolle, K., Truant, S., El Amrani, M., Zerbib, P., Pruvot, F.R., Mathieu, D., Surmei, E., Mattei, L., Marin, H., Christou, N., Ballouhey, Q., Ferrero, P., Coste Mazeau, P., Tricard, J., Barrat, B., Taibi, A., Usseglio, J., Laloze, J., Salle, H., Fourcade, L., Duchalais, E., Regenet, N., Rigaud, J., Waast, D., Denis, W., Malard, O., Buffenoir, K., Espitalier, F., Ferron, C., Varenne, Y., Crenn, V., De Vergie, S., Cristini, J., Samarut, E., Tzedakis, S., Bouche, P.A., Gaujoux, S., Kantor, E., Gossot, D., Seguin-Givelet, A., Fuks, D., Grigoroiu, M., Sanchez Salas, R., Cathelineau, X., Macek, P., Barbé, Y., Rozet, F., Barret, E., Mombet, A., Cathala, N., Brian, E., Zadegan, F., Conso, C., Blanc, T., Broch, A., Sarnacki, S., Ali, L., Bonnard, A., Peycelon, M., Hervieux, E., Clermidi, P., Maisonneuve, E., Aubry, E., Thomin, A., Langlais, T., Passot, G., Glehen, O., Cotte, E., Lifante, J.C., De Simone, B., Chouillard, E., Arnaud, A.P., Violas, P., Bergeat, D., Merdrignac, A., Scalabre, A., Perotto, L.O., Le Roy, B., Haddad, E., Vermersch, S., Ezanno, A.C., Barbier, O., Vigouroux, F., Malgras, B., Aime, A., Seeliger, B., Mutter, D., Philouze, G., Pessaux, P., Germain, A., Chanty, H., Ayav, A., Kassir, R., Von theobald, P., Sauvat, F., O'Connor, J., Mayombo Idiata, M., O'Connor, Z., Tchoba, S., Modabber, A., Winnand, P., Hölzle, F., Sommer, B., Shiban, E., Wolf, S., Anthuber, M., Sommer, F., Kaemmerer, D., Schreiber, T., Kamphues, C., Lauscher, J.C., Schineis, C., Loch, F.N., Beyer, K., Nasser, S., Sehouli, J., Höhn, P., Braumann, C., Reinkemeier, F., Uhl, W., Weitz, J., Bork, U., Welsch, T., Praetorius, C., Korn, S., Distler, M., Fluegen, G., Knoefel, W.T., Vay, C., Golcher, H., Grützmann, R., Binder, J., Meister, P., Gallinat, A., Paul, A., Schnitzbauer, A.A., Thoenissen, P., El Youzouri, H., Schreckenbach, T., Nguyen, T.A., Eberbach, H., Bayer, J., Erdle, B., Sandkamp, R., Nitschke, C., Izbicki, J., Uzunoglu, F.G., Koenig, D., Gosau, M., Böttcher, A., Heuer, A., Klatte, T.O., Priemel, M., Betz, C.S., Burg, S., Möckelmann, N., Busch, C.J., Bewarder, J., Zeller, N., Smeets, R., Thole, S., Vollkommer, T., Speth, U., Stangenberg, M., Hakami, I., Boeker, C., Mall, J., Schardey, H.M., von Ahnen, T., von Ahnen, M., Brunner, U., Tapking, C., Kneser, U., Hirche, C., Jung, M., Kowalewski, K.F., Kienle, P., Reissfelder, C., Seyfried, S., Herrle, F., Hardt, J., Galata, C., Birgin, E., Rahbari, N., Vassos, N., Stoleriu, M.G., Hatz, R., Albertsmeier, M., Börner, N., Lampert, C., Werner, J., Kuehlmann, B., Prantl, L., Brunner, S.M., Schlitt, H.J., Brennfleck, F., Pfister, K., Oikonomou, K., Reinhard, T., Nowak, K., Ronellenfitsch, U., Kleeff, J., Delank, K.S., Michalski, C.W., Szabo, G., Widyaningsih, R., Stavrou, G.A., Bschorer, R., Mielke, J., Peschel, T., Königsrainer, A., Quante, M., Löffler, M.W., Yurttas, C., Doerner, J., Seiberth, R., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Syllaios, A., Baili, E., Schizas, D., Liakakos, T., Charalabopoulos, A., Zografos, C., Spartalis, E., Manatakis, D.K., Tasis, N., Antonopoulou, M.I., Xenaki, S., Xynos, E., Chrysos, E., Athanasakis, E., Tsiaousis, J., Lostoridis, E., Tourountzi, P., Tzovaras, G., Tepetes, K., Zacharoulis, D., Baloyiannis, I., Perivoliotis, K., Hajiioannou, J., Korais, C., Gkrinia, E., Skoulakis, C.E., Saratziotis, A., Koukoura, O., Symeonidis, D., Diamantis, A., Tsoulfas, G., Christou, C.D., Tooulias, A., Papadopoulos, V., Anthoulakis, C., Grimbizis, G., Zouzoulas, D., Tsolakidis, D., Tatsis, D., Christidis, P., Loutzidou, L., Ioannidis, O., Astreidis, I., Antoniou, A., Antoniadis, K., Vachtsevanos, K., Paraskevopoulos, K., Kalaitsidou, I., Alexoudi, V., Stavroglou, A., Mantevas, A., Michailidou, D., Grivas, T., Deligiannidis, D., Politis, S., Barrios Duarte, A., Portilla, A.L., Lowey, M.J., Recinos, G., Lopez Muralles, I., Siguantay, M.A., Estrada, E.E., Aguilera-Arévalo, M.L., Cojulun, J.M., Echeverría-Dávila, G., Marín, C., Icaza de Marín, G.C., Kok, S.Y., Joeng, H.K.M., Chan, L.L., Lim, D., Novak, Z., Echim, T., Suszták, N., Banky, B., Kembuan, G., Pajan, H., Islam, A.A., Rahim, F., Safari, H., Mozafari, M., Brouki Milan, P., Tizmaghz, A., Rezaei Tavirani, M., Ahmed, A., Hussein, R., Fleming, C., O'Brien, S., Kayyal, M.Y., Daly, A., Killeen, S., Corrigan, M., De Marchi, J., Hill, A., Farrell, T., Davis, N.F., Kearney, D., Nelson, T., Maguire, P.J., Barry, C., Farrell, R., Smith, L.A., Mohan, H.M., Mehigan, B.J., Mccormick, P., Larkin, J.O., Fahey, B.A., Rogers, A., Donlon, N., O'Sullivan, H., Nugent, T., Reynolds, J.V., Donohue, C., Shokuhi, P., Ravi, N., Fitzgerald, C., Lennon, P., Timon, C., Kinsella, J., Smith, J., Boyle, T., Alazawi, D., Connolly, E., Butt, W., Croghan, S.M., Manecksha, R.P., Fearon, N., Winter, D., Heneghan, H., Maguire, D., Gallagher, T., Conlon, K., Kennedy, N., Martin, S., Kennelly, R., Hanly, A., Ng, K.C., Fagan, J., Geary, E., Cullinane, C., Carrington, E., Geraghty, J., McDermott, E., Pritchard, R., McPartland, D., Boland, M., Stafford, A., Geoghegan, J., Elliott, J.A., Ridgway, P.F., Gillis, A.E., Bass, G.A., Neary, P.C., O'Riordan, J.M., Kavanagh, D.O., Reynolds, I.S., K, Conlon, Joyce, D.P., Boyle, E., Egan, B., Whelan, M., Elkady, R., Tierney, S., Connelly, T.M., Earley, H., Umair, M., O'Connell, C., Thomas, A.Z., Rice, D., Madden, A., Bashir, Y., Creavin, B., Cullivan, O., Owens, P., Canas-Martinez, A., Murphy, C., Pickett, L., Murphy, B., Mastrosimone, A., Beddy, D., Arumugasamy, M., Allen, M., Aremu, M., McCarthy, C., O’Connor, C., O'Connor, D.B., Kent, E., Malone, F., Geary, M., McKevitt, K.L., Lowery, A.J., Ryan, É.J., Aherne, T.M., Fowler, A., Hassanin, A., Hogan, A.M., Collins, C.G., Finnegan, L., Carroll, P.A., Kerin, M.J., Walsh, S.R., Nally, D., Peirce, C., Coffey, J.C., Cunningham, R.M., Tormey, S., Hardy, N.P., Neary, P.M., Muallem-Kalmovich, L., Kugler, N., Lavy, R., Zmora, O., Horesh, N., Vergari, R., Mochet, S., Barmasse, R., Usai, A., Morelli, L., Picciariello, A., Papagni, V., Altomare, D.F., Colledan, M., Zambelli, M.F., Tornese, S., Camillo, A., Rausa, E., Bianco, F., Lucianetti, A., Prucher, G.M., Baietti, A.M., Ruggiero, F., Maremonti, P., Neri, F., Ricci, S., Biasini, M., Zarabini, A.G., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Della Gatta, A.N., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A.M., Pezzuto, A.P., Pignatti, M., Pilu, G., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Tonini, V., Sartarelli, L., Cervellera, M., Gori, A., Armatura, G., Scotton, G., Patauner, S., Frena, A., Podda, M., Pisanu, A., Esposito, G., Frongia, F., Abate, E., Laface, L., Casati, M., Schiavo, M., Casiraghi, T., Sammarco, G., Gallo, G., Vescio, G., Fulginiti, S., Scorcia, V., Giannaccare, G., Carnevali, A., Giuffrida, M.C., Marano, A., Palagi, S., Di Maria Grimaldi, S., Testa, V., Peluso, C., Borghi, F., Simonato, A., Puppo, A., D'Agruma, M., Chiarpenello, R., Pellegrino, L., Maione, F., Cianflocca, D., Pruiti Ciarello, V., Giraudo, G., Gelarda, E., Dalmasso, E., Abrate, A., Daniele, A., Ciriello, V., Rosato, F., Garnero, A., Leotta, L., Giacometti, M., Zonta, S., Lomiento, D., Taglietti, L., Dester, S., Compagnoni, B., Viotti, F., Cazzaniga, R., Del Giudice, R., Mazzotti, F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C.V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M.N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A.L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M.G., Lippa, L., 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- Subjects
Pulmonary and Respiratory Medicine ,Male ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,complication ,Article ,NO ,Cohort Studies ,outcomes ,complications ,following cardiac surgery ,coronavirus disease 2019 ,Postoperative Complications ,Cardiovascular Diseases ,Female ,Humans ,Middle Aged ,SARS-CoV-2 ,COVID-19 ,Cardiac Surgical Procedures ,Internal medicine ,Cardiovascular Disease ,medicine ,Cardiac Surgical Procedure ,In patient ,LS7_4 ,business.industry ,Cardiac surgery ,outcome ,Surgery ,Cohort Studie ,Cardiology and Cardiovascular Medicine ,business ,cardiac surgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Cohort study ,Human - Abstract
The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection was associated with an overall mortality of 24% and postoperative pulmonary complications in half of all patients.3 Cardiac surgery arguably represents a higher risk population than general or orthopedic surgery due to the high American Society of Anesthesiologists grades and multiple comorbidities usually seen. We present a subgroup analysis of COVIDSurg data, including patients who underwent cardiac surgery between March 1, 2020, and July 31, 2020, across 13 countries, with a confirmed perioperative (7 days preoperative up to 30 days postoperative) diagnosis of COVID-19 infection. This is presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology statement for cohort studies.4 Categorical variables were expressed as frequency and percentages and c2 or Fisher exact test was used to compare categorical variables. Only anonymized data were collected. Patient consent was obtained unless it was waived by local research committees. In the United Kingdom, the study was registered at each site as either a clinical audit or service evaluation and consent was waived. In other countries, local investigators were responsible for contacting research ethics committees to obtain local or national approvals in line with applicable regulations.
- Published
- 2021
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