314 results on '"Anderson, Corey"'
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52. Prohibitin levels regulate OMA1 activity and turnover in neurons
- Author
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Anderson, Corey J., primary, Kahl, Anja, additional, Fruitman, Hannah, additional, Qian, Liping, additional, Zhou, Ping, additional, Manfredi, Giovanni, additional, and Iadecola, Costantino, additional
- Published
- 2019
- Full Text
- View/download PDF
53. Spatial genetic structure within a population of nine-banded armadillos in western Mississippi
- Author
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Binns, Loren A, primary, Loughry, W J, primary, McDonough, Colleen M, primary, and Anderson, Corey Devin, primary
- Published
- 2019
- Full Text
- View/download PDF
54. AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke
- Author
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Kobayashi, Mariko, primary, Benakis, Corinne, additional, Anderson, Corey, additional, Moore, Michael J., additional, Poon, Carrie, additional, Uekawa, Ken, additional, Dyke, Jonathan P., additional, Fak, John J., additional, Mele, Aldo, additional, Park, Christopher Y., additional, Zhou, Ping, additional, Anrather, Josef, additional, Iadecola, Costantino, additional, and Darnell, Robert B., additional
- Published
- 2019
- Full Text
- View/download PDF
55. Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
- Author
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Marso, Steven P., McGuire, Darren K., Zinman, Bernard, Poulter, Neil R., Emerson, Scott S., Pieber, Thomas R., Pratley, Richard E., Haahr, Poul-Martin, Lange, Martin, Brown-Frandsen, Kirstine, Moses, Alan, Skibsted, Simon, Kvist, Kajsa, Buse, John B., Hansen, Liliana, Rabol, Rasmus, Bethel, Angelyn, de Lemos, James A., Senn, Stephen, Schwamm, Lee, Timmis, Adam, Alshekhlee, Amer, Bach, Richard G., Bertram, Therese M., Chaitman, Bernard R., Cruz-Flores, Salvador, Eckstein, Jane F., Feen, Eliahu S., Fisher, Simon J., Gosselin, Gilbert, Lim, Michael J., Rosenzweig, James L., Sherwin, Robert S., Tobin, Garry S., Vetrovec, George, Ziemer, David C., Daugaard, Gedske, Ozlem, Er, Pollak, Michael, Sengelov, Lisa, Ahn, Yu-Bae, Amod, Aslam, Benroubi, Mariana, Boonyavarakul, Apussanee, Canecki-Varzic, Silvija, Consoli, Agostino, Eliaschewitz, Freddy G., Franek, Edward, Jinnouchi, Hideaki, Khokhlov, Alexander L., Mithal, Ambrish, Philis-Tsimikas, Athena, Ong, Tiong Kiam, Pop, Lavinia, Reyna, Leobardo Sauque, Rodbard, Helena W., Roula, Daoud, Saravanan, Ponnusamy, Sesti, Giorgio, Sorli, Christopher, Sposetti, Georgina, Tinahones-Madueno, Francisco-Jose, Woo, Vincent, Berard, Lori, Caballero Mateos, Irene, Cooper, Alison, DeLuca, Clarisa, Fillary, Julie, Gan, Diyana Gan Abdul Rahman, Goondiwala, Amina, Tapia, Jessica, Busch, Robert, Chaykin, Louis, Hollander, Priscilla, Karounos, Dennis, Lane, Wendy, Lingvay, Ildiko, Odugbesan, A. Ola, Ohlson-Elliott, Theresa, Ovalle, Fernando, Pantalone, Kevin M., Phelps, Spencer, Pop-Busui, Rodica, Robertson, David, Shlesinger, Yshay, Silver, Robert, Warren, Mark, Arrar, Mohammed, Belkheir, Hassani, Benabbas, Youcef, Benferhat, Schahrazed, Benoun, Fatima, Bensalem, Samia, Bourezane, Samia, Elaoufi, Selmane Rafik, Gourine, Mouna, Hadjhabib, Mohamed, Hadjhamou, Fouzia, Hakem, Jamila, Kaouache, Nadjib, Khensal, Sabrina, Kitouni, Yacine, Lakhal, Lamine, Lezzar, Al-Kassem, Meftah, Imane Aicha, Mehenni, Lahouaria, Nouri, Nassim, Oumerzouk, Fatma, Sakouhi, Mounia, Talha, Kheira, Zemri, Zouaouia, Caeiro, Gabriela, Calveyra, Martha, Cluigt, Natalia, Geronazzo, Veronica, Lema, Silvina, Monferran, Pablo Martinez, Oviedo, Alejandra, Pozzi, Jose, Sala, Jorgelina, Schindler, Ana, Sernia, Virginia, Sicer, Maximiliano, Solis, Silvana, Varela, Patricia, Waitman, Jorge, Augusto, Gustavo Akerman, Alves, Breno, Alves, Erica, Barbosa, Luciana, Bona, Renata, Borges, Joao, Bosco, Adriana, Canani, Luis, Castro, Denise, Cavalcante, Lilian, Cechin, Laura, Cercato, Cintia, Chrisman, Carlos, Chrisman, Carolina, Cintra, Rebecca, Costa, Giselle, Fontenele, Ana Paula, Forti, Adriana, Francisco, Beatriz, Franco, Denise, Genestreti, Paulo, Gross, Jorge, Haddad, Ludmila, Halpern, Alfredo, Hissa, Miguel, Leanca, Camila, Leao, Beatriz, Marinho, Ana Elisabeth, Miranda, Isabela, Nunes, Adriano, Palhares, Fabiana, Poco, Christiani, Salles, Joao, Sampaio, Celia, Santomauro Jr., Augusto, Sartori, Carla, Sena, Rita, da Silva, Marina, da Silva, Paula, Siqueira, Katia, Turatti, Luiz, Valenti, Adriana, Vasques, Enio, Vencio, Sergio, Visconti, Guilherme, Belanger, Andre, Chilvers, Martyn, Dumas, Richard, Hurd, Carmen, Lafleche, Francois, Lam, Paul, Martinho, Valdemar, Palardy, Jean, Peterson, Sean, Raff, Errol, Sinnaeve, Linda, Sullivan, David, Baraban, Vedrana, Blaslov, Kristina, Bulum, Tomislav, Varzic, Silvija Canecki, Berkovic, Maja Cigrovski, Balen, Marica Jandric, Kruljac, Ivan, Lesnjakovic, Silvija, Lucijanic, Tomo, Majic, Ana, Rahelic, Dario, Smircic-Duvnjak, Lea, Vrkljan, Milan, Zibar, Karin, Zukanovic, Sidbela, Athanasopoulou, Elpida, Benis, Apostolos, Benroubi, Marian, Diakoumopoulou, Evanthia, Doupis, John, Griva, Theodora, Kazakos, Kyriakos, Kypraios, Nikolaos, Liatis, Stavros, Makrilakis, Konstantinos, Markou, Athina, Pagkalos, Emmanouil, Papanastasiou, Labrini, Piaditis, George, Sampanis, Christos, Siami, Evangelia, Tentolouris, Nikolaos, Tsiama, Vasiliki, Zografou, Ioanna, Adling, Pravishal, Ali, Mazher, Anjana, R. 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P., Sivagnanam, Nallaperumal, Tandon, Nikhil, Thonangi, Rajesh, Thulaseedharan, N., Toraskar, Kedar, Varthakavi, Premalatha, Yadav, Sameer, Andreozz, Francesco, Arturi, Franco, Baldassarre, Maria Pompea Antonia, Barone, Milena, Bonura, Alice, Bucciarelli, Loredana, Buscemi, Chiara, Buscemi, Silvio, Carnovale, Anna, Caselli, Chiara, Ceci, Gloria, Cimino, Elena, Colella, Alessandra, Crippa, Valentina, Cufone, Sabrina, D'Erasmo, Laura, De Remigis, Alessandra, Di Bartolo, Paolo, Dionisio, Rosa, Disoteo, Olga, Fabietti, Marcella, Febo, Fabrizio, Filetti, Sebastiano, Genovese, Stefano, Ginestra, Federica, Grancini, Valeria, Grieco, Elvira, Magistro, Andrea, Maranghi, Marianna, Monti, Lucilla, Orsi, Emanuela, Pellicano, Francesca, Pergolini, Daniela, Perticone, Francesca, Piatti, PierMarco, Pizzi, Gianluigi, Rondinelli, Maurizio, Rossi, Margherita, Rubino, Mariangela, Setola, Emanuela, Succurro, Elena, Tarquini, Giovanna, Tiseo, Giusy, Tonolo, Giancarlo, Villa, Valentina, Hong, Stefania Vo, 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Fong, Alan Yean Yip, Ghapar, Abd Kahar Abd, Hanafi, Norliza, Abu Hassan, Muhammad Radzi, Iberahim, Rahimah, Khiew, Ning Zan, Lee, Gary Chin Keong, Lingam, Rakesh, Long, Richard Chay Shien, Mahendran, Kauthaman A., Oon, Yen Yee, Said, Asri, Sothiratnam, Radhakrishna, Sridhar, Ganiga Srinivasiah, Suan, Mohd Azri Mohd, Tan, Sian Kong, Tey, Julian Hock Chuan, Undok, Abdul Wahab, Waid, Anuar, Vijayasingham, Shalini, Voon, Chi Yen, Yew, Kuan Leong, Yong, Lit Sin, Aguilar-Parra, Lilia, Aguirre, Karen, Alvarez-Carrillo, Rebeca, Arechavaleta-Granell, Maria, Baez-Campos, Aurelia, Bayram Llamas, Edmundo Alfredo, Calvo-Vargas, Cesar, Cedano-Limon, Marielena, Beltran Jaramillo, Teresita de Jesus, de Jesus Marin-Lopez, Jose, Ruiz Cornejo, Maria de Jesus, Juarez Cervantes, Maria del Carmen, Estevez de Alba, Isabel, Estrada Garcia, Raul, Estrada, Suellen, Garza-Vergara, Marisol, Gonzalez-Perez, Rosa, Gonzalez-Valencia, Carlos, Guerrero-Reyes, Rosalinda, Haro Ortiz, Jose Alfredo, Hernandez Salazar, 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David, Carangi, Gwen, Cohen, Kenneth, Daza-Taylor, Kristen, Diesburg-Stanwood, Amy, Douglass, Sara, Finck, Lani, Karaboitis, Krisoula, Kerstein, Howard, Lesh, Kurt, Loesch, Ryan, McClure, Lori, Nevarez, Max, Pavol, Bristol, Rasouli, Neda, Rockler, Briana, Sanagorski, Rebecca, Solano, Royce, Underkofler, Chantal, Van Winkle, Rebecca, Weiss, Sarah, White, Katherine, Wirtemburg, Patricia, Zarrabi, Lida, Zemel, Leonard, Barchini, George, Casagni, Kimberely, Cordisco, Marie Elena, Davis, Amanda, Duffy-Hidalgo, Bobbi, Huntley, Richard, McNicol, Donald, Miller, Neil, Mukwaya, Margaret, Northrup, Patricia, Platt, Jonathan, Rabideau, Diane, Randolph, Pamela, Rose, Suzanne, Samuel, James, Savino, Robert, Soufer, Joseph, Torello, Carole, Abinader, Azarel, Agosto, Milagos, Aguirre, Frank, Alexander, Lori, Almanza, Orlando, Alvarez, Dalia, Anees, Muhammad, Aqua, Keith, Arazo, Luz, Asberry, Claudia, Ashley, Alyssa, Balentine, Tracy, Barta, Melissa, Bertot, Ivan, Binns-Leon, Michelle, Borello, Nora, Bostick, Janette, Boucher, Loria, Braddy, Dalton, Breton, Cristian, Broxton, Bridgitte, Burke, Deborah, Cabielles, Tania, Calderon, Juan, Canaan, Yamil, Canelon, Gustavo, Cardona, Jose, Castillo-Gonzalez, Sheila, Castro, Kenia, Chacon, Jessica, Chehade, Joe, Church, Lara, Cohen, Lisa, Crews, Erin, Cromer, Carol, Cromer, Michael, Cuello, Jorge, Cusi, Kenneth, de Leon, Karel, Delgado, Edmund, Delima, Selma, Denson, Janneral, DeVries, Benjamin, Diaz, Maritza, Digon, Beningo, Dowell, Michelle, Dunn, Kelly, Ellington, Dickson, Emerick, George, Encarnacion, Frances, Ezell, Leslie, Fahmie, Ashley, Fernandez, Noel, Figueredo, Rommel, Flores, Patricia, Fonseca, Juan, Freeman, Alain, Freeman, Erica, Frias, Juan, Garcia, Lazaro, Geronilla, Giovanni, Hamilton, Maxine, Hanabergh, Rodolfo, Hanson, Lenita, Harris, Kim, Hasan, Syed, Hendrick, Mary, Hicks, Melissa, Hoffman, Lara, Holt, Antoniwa, Hutchinson, Rachel, Iparraguirre, Harold, Janicka, Ania, Janovitz, Richard, Jones, Dawn, Jones, Sarah, Kaplun, Polina, Kelijman, Mirtha, Kersey, Angela, Khan, Ashraf, Khan, Misal, Kirk, Gregory, Konwai, Ada, Kovar, Meghan, Kutner, Mark, Lafaille, Jimmy, Leach, Dana, Levenson, David, Lewy-Alterbaum, Lorena, Light, Timothy, Lo, Margaret, Loman, Lusiana, Long, Sarah, Love, Jeremy, Madera, Arelis, Magee, James, Mallitz, Michelle, Marquez, Farid, Marshall, Richard, Mary, James, Mateu, Janet, McKenzie, Leanna, McKenzie, Rona, McKenzie, Wilfred, Mendelson, Reina, Mendez, Janet, Merlos, Ledis, Mierau, Jennifer, Miller, Robert, Miranda-Palma, Bresta, Montoya, Carla, Navarro, Eduardo, Neller, Christian, Nossa, Janette, Osborn, Tracey, Patel, Bijal, Penabad, Jesus, Perez, Gilberto, Pineda, Daniel, Pinero-Pilona, Antonio, Platt, George, Prestwood, Elfrida, Quintero, Luis, Rengifo, Rodney, Reyes, Dannier, Rivas, Aolani, Rivero, Mileydis, Robinson, Sonya, Robison, Dawn, Rodriguez, Dalier, Rodriguez, Ivete, Rodriguez, Toni, Rosario, Cristobal, Rosenwasser, Rebecca, Roura, Miguel, Schramm, Erich, Schramm, Rashi, Schweppe, Laurie, Segel, Scott, Sepulveda, Maria, Sheets, Lori, Shields, Karen, Smith, Krystal, Smith, Meridith, Somerstein, Claudia, Solano, Maria, Suarez, Manuel, Suarez, Omar, Suarez, Rogelio, Suarez, Victor, Sultan, Senan, Sutton, David, Szilagyi, Istvan, Thorne, Margaret, Travaglini, Stefano, Trevino, Miguel, Uriarte, Oscar, Vizcaino, Luis, Wadud, Khurram, Wehmeier, Kent, Weinstein, Debra, Welch, Celeste, White, Alexander, White, Basil, Williams, Tammy, Williamson, Cathi, Zwick, Lisa, Adams, Cynthia, Arkin, David, Bode, Bruce, Bonner, Sheila, Bonner, Wes, Bowen, Danielle, Bradley, Brooke, Bradley, Paul, Brennan, Elizaebeth, Brown, Cynthia, Brown, De'Aira, Burgess, Elizabeth, Collett, Taryn, Cook, Jennifer, Corse, Steven, Dukes, Kaitlyn, Durrence, Jenna, Dutton, Robin, Estes, Susie, Falcone, Laura, Gaskin, Katherine, Goswami, Ketan, Hart, Mari, Jester, Donni, Kies, Staci, Leiker, Abigail, Lu, Peter, Mahakala, Aparna, Maher, Maxine, Miller, Alan, Miller, Todd, Munoz, Miguel, Musto, Michele, Odugbesan, Adeniyi, Olson, Darin, Osborn, Nicole, Pace, Kerri, Pajkovic, Gordana, Paulus, Carolyn, Phillips, Lawrence, Reddick, William, Reed, John, Rowe, Shasta, Sadler, Barney, Sapp, Tabby, Savoye, Louise, Shore, David, Shuman, Susan, Sittle, Jessica, Standard, Shana, Wardell, Karla, Workman, Amy, Carreira, Tabitha, Fitz-Patrick, David, Hean, Vutheary, Limcolioc, April, Nihei, Megan, Park, Youngmee, Pau, Cindy, Shannon, Lindsey, Trotter, Alanna, Williams, Sierra, Coughenour, Tiffany, Liljenquist, John, Vance, Carl, Williams, Jonathan, Agaiby, Eva, Agaiby, John, Argo, Kelly, Azad, Nasrin, Backus, Arnetta, Bartlett, Andrew, Bellucci-Jackson, Jennifer, Boncu, Otilia, Brodt, Pamela, Carlson, Hope, Collins, Kathleen, Delibasic, Maja, Dor, Isaac, Dukett, Mary, Emanuele, Nicholas, Gabel, Faith, Giardino, Alexandra, Hoelzer, David, Hsieh, Annming, Jayaramaiah, Poornima, Kearney, Tracy, Kelley, Kathleen, Kravarusic, Jelena, Lawless, Andrea, Maheshwari, Hiralal, Martin, Elonia, McCall, Linda, Mikell, Frank, Nallala, Deepika, Said, Sufyan, Sakla, Nadia, Schiferi, Joanna, Smith, Patricia, Stokes, John, Sugimoto, Danny, Sugimoto, Michael, Swan, Delores, Alfata, Sarab, Beavins, Jill, Bogardus, Christine, Bogardus, Donald, Calvert, Brittany, Calvin, Krystle, Carlton, Kristin, Condit, Jonathan, Cornett, George, Covert, Carissa, Dela Llana, Alexander, Dixon, Rosie, Felker, Dean, Fogle, Sara, Harris, Leslie, Hoebeke, Roberta E., Silva, Ricardo, Johnson, Tabitha, Johnston, Kelly, King, Jennifer, Lang, Amber, Maynard, Kenneth, McDaniel, Vickie, McGrath, Caitlin, Moretto, Thomas, Ndukwu, Ikeadi, O'Connor, Leo, O'Connor, Thomas, Oliver, Tonya, Overmars, Stephanie, Patel, Minesh, Patterson, Geraldine, Powell, Talessa, Raphael, Annmarie, Raphael, Rod, Reedy, Mark, Reyes, Hubert S., Ridge, Terry, Rutherford, Mary S., Sebastian, Mike, Shaeffer, Laura, Sheets, Michelle, Thomas, Karen, Trueblood, Nancy, Tucker, Tiffany, White, Adrian, Wooldridge, Evan, Wright, Alison, Zapinski, Dawn, Cieloha, Megan, Coker, Clarine, Fletcher, Cherisa, Kay, Jennifer, Larsen, Katelyn, Marar, Isam, Motz, Zachary, Paul, Jamie, Pokorski, Alan, Rabadi-Marar, Diana, Scheideler, Kylie, Sobczyk, Jill, Sweeney, Kolbie, Brink, Nathalie, Buth, Dennis, Grimes, Katlyn, Lakin, Gregory, Loewen, Barbara, Secrist, Neal, Simon, William, Steere, Diane, Talbot, Kimberly, Wheeler, Christina, Adams, Derick, Armour, Wilhelmina, Asher, Whitney, Bays, Harold, Behl, Noreen, Conn, Brittany, Dye, Lyndsey, Earl, Jennifer, Farris, Neil, Figueroa, Sergio, Fruit, Olivia, Hobbs, Coury, Howard, Kristen, Jackson, Tamara, Kain, Angela, Karounos, Chrisi, Keiran, Sarah, Kennedy, Ryan, King, Kara, Krishnasamy, Sathya, Lambdin, Winona, Micklewright, Gezina, Mokshagundam, Sri, Mooney, Stephen, Moore, Melanie, Morgan, Denise, Morley, Robert, Newsome, Stacy, Nichols, Jennifer, Nims, Diana, Nockerts, Nichole, Oremus, Ruth, Ritchey, Barbara Michelle, Shelton, Christina, Smith, Danielle, Walker, Debra, Weiter, Kathleen, Whitehead, Rebecca, Wood, Robert, Woodruff, Robin, Young, J. DeShay, Alper, Arnold, Berry, Martha, Gauthier, Nadine, Griffin, Catina, Haynes, Elvia, Lawrence, Jereta, McCormack, Teraina (Terry), Midyett, Catherine, Rangaraj, Uma, Smith, William, Stricker, Makenzie, Tandron, Ileana, Vargas, Ramon, Wagner, Michele, Albert, Marie, Baillargeon, Gail, Stephens, John, Aroda, Vanita, Dempsey, Michael, Junker, Herman, Lopez, Meyling, Shepard, Marc, Ciccarelli, Carol, Datu, Joycelyn, Gallagher-Dorval, Karen, Hartigan, Celia, Kowaloff, Edward, Lock, John-Paul, Rosano, Nina, Shaw, Bernadette, Thompson, Michael, Abbo, Camerin, Anton, Salwan, Baker, Lydia, Bhan, Arti, Blackmer, Karla, Boley, Bryon, Hyde, Desirae, Bonema, John, Carlin, Tamara, Curran, Nancy, Dandois, Bethani, Dermyer, Abigail, Dubeck, Janet, Elkins, Jennifer, Ferris, Pamela, Fraser, Neil, Kozma, Julia Gargan, Gasparovich, David, Grodman, Robert, Hampson, Jaison, Hewitt, Mitzie, Hiatt, Judy, Hopkins, Ashley, Howard, Jennifer, Joliat, John, Joliat, Jonathan, Kalt, Steven, Katzman, Steven, Kogelman, Jesse, Kruger, Davida, Kurkowski, April, Lambert, Jodi, Levcovici, Elisabeta, Lockwood, Karen, Lumberg, Michael, McMullen, Lindsay, Meyers, Peter, Minto, Carrie, Nelson, Tina, Neuner, Gregory, Nurmi, Kevin, Perkins, Judy, Plunkett, Cynthia, Ruoff, Gary, Samantray, Julie, Sawah, Ahmed, Secord, Samantha, Seyoum, Berhane, Sherman, Sarah, Simpson, Michael, Sinkoff, Mark, Skoney, Joseph, Small, Jami, Szerlong, Heidi, Tinetti, Timothy, Toomey, Adam, VanDerWerff, Holly, Whitehouse, Fred, Wilkins, Raechelle, Wolf, Stephanie, Yarows, Steven, Eldred, Edward, Hester, Kim, Huling, Randall, Moore, Kerry, Preslar, Kristina, Proge, Nakia, Smith, Lora, Young, Gerri, Bybee, Kevin, Carr, George, Case, Christopher, Forker, Alan, Goeke, Lindsay, Kocher, Darlene, Lin, Oscar, Littlefield, James, Mendoza, Robinson, Moore, Michelle, Oberhaus, Barbara, Reed, Larry, Rutherford, Cheryl, Windsor, Sheryl, Ackerman, Kim, Christensen, Reed, De Souza, Jose, Douglas, Kirsten, Hrncirik, Therese, Lefkowicz, Magen, McDonnell, Lindsey, Severa, Larry, Tjaden, Jeffrey, Ward, Laura, Addison, Shayla, Anderson, Robert, Baker, Claire, Baum, Robert, Belitz, Jenny, Boerner, Shannon, Desouza, Cyrus, Drincic, Andjela, Fitzgibbons, William, Francis, Jessica, Garvin, Maureen, Goldner, Whitney, Goodrich, Melissa, Grubbs, Lisa, Hatcher, Theresa, Hochstein, Renee, Hunter, Christine, Keuchel, Janet, Konigsberg, Sarah, Kuechenmeister, Lisa, Mack, Lynn, McKnight, Thomas, Mensik, Hanna, Mitchell, Jan, Moeller, Jennifer, Montanez, Edward, Montoya, Paul, Nemecek, Tiffany, Neumeister, Amy, Newcomb, Jefferey, Pracht, Shelby, Radke, Kaitlin, Rahman, Jennifer, Renter, Samantha, Reynolds, Jill, Grace Rodriguez, Maria, Satorie, Jessica, Schiermann, Lynnda, Severson, Megan, Shivaswamy, Vijay, Snyder, Janice, Tillson, Renee, Vasey, Andrew, Wahl, Timothy, Weeks, William, Wolf, Thomas, Springer, Brian, Mitchell, Janice, Woodruff, Mark, Alvarez, Isis, Bowers, Rachel, Cala-Anaya, Franklin, Castellanos-Rodriguez, Rudiber, Christopher, Janice, Concepcion, Gelvis, Fernandez, Dareana, Ghanem, Paula, Harmon, Nicolette, Kaiser, Heather, Kaplan, Westbrook, Klugh, Serena, Le, Nicholas, Lehrner, Stephanie, Lopez, Robert, Martin, Olga, Martinez, Tina, Martini, Nicole, Molin, Clifford, Nakhle, Samer, Newsome, Yvonne, Neylon, Ellen, Olsen, Jarvis, Palal, Betsy, Philander, Peter, Rosario, Adriana Ruiz, Sanchez, Mary, Sierra-Garcia, Miguel, Smith, Myesha, Trenche, Samuel, Trippi, Danna, Vernetti, Nicholas, Villegas, Laura, White, Briana, Wilcox, Simmon, Carmolli-Cornette, Lisa, Chuang, Ellie, Hoffman, Sheila, Laliberte, Alison, Marshall, Lisa, Meroski, Pamela, O'Neil, Christine, Shippey, Jeanette, Spector, Linda, Cam, Jenny, Chen, Tina, Damle, Jagadish, Holman, Rebecca, Liu, Jenny, Milazzo, Carmelo, Quach, Brenda, Yang, Bin, Ahmad, Basharat, Aro, Dominic, Azeem, Fouzal, Bonaccorso, Antoinette, Brancato, Lenore, Brautigam, Donald, Charatz, Seth, Chiarot, June, Cunningham, Linda, DiCerbo, Nancy, DiGiovanna, Michael, Dluge-Aungst, Dawn, Dolbeer, Traci, Donovan, Daniel, Duma, Carol, Ellwood, Rebecca, Freedman, Zachary, Gorman, Timothy, Gunther, David, Hogan, Eileen, Hoffman, Lisa, Kapoor, Anoop, Kelly, Michelle, Kitchen, Timothy, Lam, David, Levister, Camilla, Levy, Carol, Lopez, Carlos, Lyons-Patterson, Jane, Makam, Sashi, Mauceri, Diana, McClary, Carole, Murak, Daniel, Nolan, Kelly, Nunez, Carlos, Elliott, Theresa Ohlson, Ostrowski, Phillip, Pallai, Ajish, Porges, Andrew, Rodes, Alfredo, Rosenberg, Richard, Rubel, Lance, Serrano, Lelanie, Shannon, Daniel, Sinha, Rabi, Snyder, Brian, Sy, Claude, Tang, Rocky, Varavenkataraman, Raghupathy, Winterberger, Amy, Allen, Stacy, Anderson, Marshall, Asbill, Mark, Beasley, Amanda, Bennett, Chrisitian, Bergamo, Katherine, Bilbro, Scott, Brannock, Sarah, Brown, Laura, Bryant, Danielle, Buck, Genena, Burdette, Tara, Buse, John, Butler, Laura, Caldwell, Ronald, Cannon, Daniel, Cannon, Kevin, Carter, Casey, Cherry, Amanda, Comer, Zoe, Crittenden, Susan, Cuffee, Juanita, Culmer, Dawn, Daly-Barnes, Kristie, Evensen, Erick, Saavedra, Rubin, Dean, John, Dezube, Milana, Diner, Jaime, Dodis, Regina, Dostou, Jean, Duclos, Michelle, Elmore, Miles, Ferree, Kristin, Foster, Leslie, Fuller, Gail, Garner, Susan, Godwin, Sarah, Goley, April, Gore, Whitney, Green, Brenda, Harris, Elizabeth, Harris, Joy, Harris, Rebecca, Hatharasinghe, Roger, Herring, Charles, Hill, Chernessa, Holmes, Robert, Hutchens, Erin, Jennings, Stuart, Kaake, Ashley, Kaygun, Handan, Kirkman, Marian Sue, Kretzschmar, Heather, Lang, Jaqueline, Largay, Joseph, Lewis, Melissa, Long, Maria Ann, Lucas, Kathryn, McCall, Roshanda, McDaniel, Catrina, McGinnis, Lee Ann, Mogabgab, Edward, Montero, Manuel, Montgomery, Richard, Moran, Joseph, Morgan, Katie, Motley, Taylor, Narendran, Mahendra, Narron, Brooke, Newman, Walter, Nicholson, John, Norris, Stephanie, Norton, Jennifer, Nowell, Erin, O'Brien, Heather, Otero, Heydin, Perkins, Victoria, Quesada, Reyna, Raad, George, Raley, Rosalie, Raman, Sujatha, Rappaport, Jonathan, Ray, Robert, Ray, Shannon, Rice, Lucian, Roberts, Christine, Ross, Kaylee, Scanlon, Erica, Schroder, Derek, Schulte, Michelle, Schultzaberger, Richard, Shoffner, Sylvia, Skrzynski, Michael, Smith, Brian, Smith, Holly, Smith, Jennifer, Smith, Justin, Smith, Kendall, Smith, Leigh, Sparks, Jeffrey, Speece, Jessica, Spivey, Jessica, Stebich, Andrew, Temple, Karen, Tessena, Boryana, Thompson, Casey, Traylor, Henry, Turner, Juliana, Turner, Sh-Rhonda, Van Cleeff, Martin, Vukojicic, Katarina, Wanchick, Leslie, Weinrib, Stephen, Werner, Devorah, Wishon, Candace, Wilson, Jonathan, Wilson, Stephanie, Wright, Heather, Young, Laura, Brown, Jamie, Lillestol, Michael, Allen, Mary Jo, Barker, Bruce, Bedel, Gary, Beuerlein, Shawn, Bhati, Amar, Breslaw, Nicole, Brown, April, Burtch, Brian, Check, Ellen, Chiodi, Shawnie, Colosimo, Linda, Cope, Kathie, Coressel, Denise, Cramer, Bethany, Crowel, Amy, Daboul, Nizar, DeLong, Rebecca, Dirkes, William, Farooki, Zia, Fixler, Don, Friedhof, Linda, Griffen, Julie, Hagan, Anjani, Haney, Kevin, Harris, Kira, Hoffmann, Amanda, Hsieh, Ronald, Ismail-Beigi, Faramarz, Kelso, Kim, Khamousia, Nidaa, Kremer, Gerald, Krol, Adrienne, Kulow, Tanya, Kuttler, Mary, Lee, Andy, Leksan, Jane, McElroy-Marcus, Susan, McNeil, Donald, Mulligan, Guy, Pantalone, Kevin, Perrino, Frank, Peysha, Lori, Pickett, Alicia, Pritchard, James, Provanzana, Kathleen, Rancitelli, Philip, Raupp, Randa, Schnall, Adrian, Siddiqui, Jaweriah, Smith, Cynthia, Sood, Ajay, Sortor, Jennifer, Spinelli, Kristin, Taylor, Diana, Thornton, Aaron, Tiktin, Margaret, Twine, Melissa, Urbank, Ann, Voegele, Francis, Wang, Lawrence, Weiss, Daniel, Werner, Amanda, Williams, Daniel, Wilson, Charles, Aberle, Teresa, Arcon-Rios, Sirlys, Arodak, Bassam, Aziz, Ammara, Bixler, Lacey, Brisko, Carolann, Cannon, Melanie, Choe, James, Connery, Lisa, Elkosseifi, Myriam, George, Aja, Hummer, Kimberly, LaBryer, Lauren, Lane, James, Lim, Jonea, Mirza, Lubna, Mittadodla, Saritha, Priest, Diane, Rao, Veitla, Ricci, Cassie, Salazar, Jennifer, Shaw, Jessica, St John, Jennifer, Talsania, Mitali, Joarder, Farahnaz, Riddle, Matthew, Yuen, Kevin, Ahmed, Intekhab, Austin, Barry, Bagnata, Linda, Bartkowiak, Anthony, Batrus, Jennifer, Baumgarten, Thomas, Belejchak, Paula, Belucher, Christine, Benton, Julia, Berger, Peter, Biscoveanu, Mihaela, Blasick, Abbie, Blyler, Kay, Casey, Linda, Chandler, Bronell, Chapman, Kim, Chou, Brian, Cisar, Jennifer, Clatterbuck, Tabetha, Cook, Richard, Cook II, Richard, Dardi, Inderpreet, DeSalle, Dina, Edevane, Shari, Elliott, Kelsey, Everhart, Brian, Furlong, Kevin J., Geishauser, Jennifer, Goisse, Marcy, Goodman, Yvonne, Gordon, Murray, Gutowski, Catherine, Harris, Ronald, Hu, Ying, Hull, Jenny, Iachini, Kathleen, Iannamorelli, Anthony, Jabbour, Serge, Jackson, Timothy, Jameson, Brian, Janosov, Paula, Jordan, Terry, Kennedy, John, Kurtzer, Gayle, Labuda, Joseph, LaRochelle, Anne, Levinson, Lawrence, Madder, Robert, Marconnet, Kari, Mareda, Patricia, Michael, Donna, Michaels, Debra, Miller, Cathy, Miller, Jeffrey, Minnock, Ann, Mitchell, Michele, Moturi, Hemlata, Moyer, Heather, Nagelberg, Steven, Oliver, Michael, Pepe, Constance, Porter, Patricia, Posey, Dora, Purighalla, Raman, Redmond, Jessica, Reiling, Joseph, Reiling, Susan, Rine, Kathy, Rust, William, Sandutch, Jill, Shaffer, Anette, Shalongo, Annette, Shawley, Sarah, Shonk, Pamela, Singh, Vinay, Slucki, Andrea, Spiller, Kellie, Springer, Nina, Sprouse, Heidi, Sun, Albert, Taylor, Judith, Watine, Robert, Watkinson, Jean, Weaver, Nancy, Wenocur, Howard, Yeoman, Gary, Ackermann, Jeremy, Averill, Nathan, Ballard, Thomas, Byars, William, Carter, Caroline, Castay, Cathleen, Cheek, Shonda, Collins, Jessica, Collins-Jamison, Traci, Cooksey, Erin, Crockford, Nicole, Cutshall, Christopher, Dar, Moahad, Drake, Almond, Dugat, Kameron, Durham, John, Durham, Nancy, Eagerton, Donald, Edmonds, Nataish, Farmer III, Joseph, Fogarty, Charles, Gatlin, June, Geisberg, Harry, Grossman, Margaret, Harrell, Wendy, Harrison, John, Harrison, Kristina, Heincelman, Sarah, Holladay, Lauren, Huberty, Chad, Isakov, Ingrid, Jordan, Norma, Kunkel, Michael, Laserna, Susan, Lawrence, Amanda, Lawrence, Andrew, Livingston, Yolanda, Lloyd, Eric, Lopez, Lina, Manuel, Joyce, Mayfield, Ronald, McDonald, Margaret, Morgan, Caroleann, Munn, Joanie, Murphy, Lauren, Nicol, Brent, Nicol, Philip, Norris, Rebecca, Phillips, Bunny, Reeves, Angela, Roach, Jacqueline, Ross, Irene, Santi, Jeffrey, Saunders, Jacqueline, Shugart, Henry, Singleton, Monnieque, Slee, Erin, Smalley, Kathleen, Smith, Kristy, Sofley, Carl, Solheim, Vesna, Spell, Samantha, Tanenberg, Robert, Whitley, Chester, Widel, Michele, Wilhoit, Gordon, Wood, Ruth, Wright, Jaime, Wulf, Alissa, Zapkowski, Julie, Adams, Kristi, Adams, Roberta, Ananthula, Parvati, Bass, Caitlin, Bates, Chad, Baum, Howard, Bays, Anna, Beck, Teresa, Bilbrey, Brett, Brown, Ashley, Carlton, Anna, Carter, Jenny, Cheri, Laura, Childress, Richard, Cloud, Mark, Cohen, A. Jay, Coulter, Alice, Dotson, Kimberly, Green, Christopher, Helton, Ashley, Houstrup, Jody, Huffman, David, Hurst, Fred, Hurst, James, Jantzi, Curtis, Jerkins, Randy, Jerkins, Terri, Jones, Mandy, Kelley, Shane, Kroulek, Judy, Lawhun, Dennis, Lee, Marcus, Louthan, James, Manning, Rickey, May, Michael, Means, Katherine, Monroe, Jeanabe, Morawski, Emily, Morin, David, Morris, Barbara, Murray, John, Nichols, Robert, Olivi, Stacie, Pennington, Kristina, Poe, Jenny, Pour, Omid Rad, Reeves, Michael, Reeves, Pamela, Root, Connie, Rose, Karen, Rutledge, Lily, Ryan, Eugene, Schwartz, Patricia, Shafer, Jennifer, Singh, Chitra, Smith, Ashley, Snow, Rodney, Stamps, Henry, Staton, Peggy, Stevens, Jeffrey, Stovall, Cathy, Sturgeon, Rodney, Tapp, John, Tapp, Stacy, Warner, Carla, Weiss, Melissa, White, Judith, Wierum, Craig, Williams, Konya, Wright, Tiffanie, Abreu, Marconi, Agarwal, Vandana, Ahmad, Aftab, Ahmad, Asma, Ahmed, Faiz, Ahn, Lily, Alaoui, Rachid, Alarcon, Stephanie, Allison, Dale, Annamalai, Rajasekaran, Arain, Khadija, Arellano, Angelica, Arispe, Barbara, Aronoff, Stephen, Arroyo, Jesus, Bachand, Trista, Bailey, Becky, Bajaj, Chris, Banarer, Salomon, Barnella, Christine, Bartz, Mary, Bates, Jason, Becerra, Karen, Benavides, Melissa, Bhuchar, Subodh, Blevins, Thomas, Bonazzi, Amanda, Brinson, Cynthia, Brown, Timiki, Buckley, Brandee, Bunker, Christy, Burbano, Jose, Busch, Vickey, Bustamante, Rosibel, Calais, Natalee, Camacho, Allison, Camp, Shana, Canada, Nancy, Canchola, Daniel, Cano, Monica, Cardenas, Veronica, Carl, Leighton, Casaubon, Luis, Castaneda, Jessica, Castro, Cindy, Ceniceros, Diego, Chaicha-Brom, Tira, Chaudhuri, Sudipta, Chavez-Velazquez, Alberto, Chen, Jocelyn, Cheyne, Theresa, Chilka, Sapna, Chionh, Kristen, Chunawala, Imran, Cope, Pamela, Cotton, Sonja, Daudjee, Munib, Davidson, Tichina, De Loa, Geraldine, Deniega, Ann, Dillow, Naco, Dominguez, Michael, Dorfman, Steven, Doshi, Ankur, Dunnam, Theresa, Dutta, Papiya, Eiler-Prater, Megann, Eizensmits, Christina, Espinosa, Valerie, Evans, Charles, Frisinger, Cathy, Ganta, Shylesh, Galtney, Kirsten, Gammon, John, Garcia, Analisa Marie, Garcia, Ronald, Glaspie, Tina, Golici, Laura, Gonzalez, Julian, Grant, David, Green, Carrie, Groce, Lindsay, Guevara, Stephanie, Gutierrez, Mary, Hance, Cortney, Harden, Tiffany, Harrison, Lindsay, Herrera, Carlos, Hettler, Evelyn, Holcomb, Michelle, Hoste, Laura, Hudson, Tina, Huerta, Leticia, Jain, Mahendra, Jayaram, Preeth, Johnson, Monique, Johnson, Olivia, Jones, Laurie, Joseph, John, Juarez, Misty, Karimjee, Najmuddin, Kephart, Ashley, Khan, Armgan, Khan, Jalil, Killian, Michael, Kniffen, Wendy, Koops, Maureen, Kwan, Louise, La, John, Laabs, Jessica, Ledesma, Gilbert, Lee, Monica, Leuck, Kathryn, Livingston, Carrie, Llanas, Teresa, Longoria, Andy, Lorta, Jesse, Lothringer, Larry, MacAdams, Maria, MacAdams, Michael, MacGillivray, Brian, Mageno, Melissa, Malek, Megan, Manley, Meghan, Marler, Karen, Martinez, Cristina, Massie, Jodi, Mateos, Glenda, Mathew, Reena, Maya, Claudia, Mazour, Meg, Mbogua, Caroline, McClendon, Robert, McMullen, Deirdre, Meisner, Carl, Menchaca, Ethelina, Meyers, Linda, Miklius, Audrey, Milam, Alissa, Milam, Ronnie, Miller, Tracey, Mize, Lisa, Moczygemba, Roger, Nafegar, Alexandria, Naidu, Jayaram, Nair, Archana, Nguyen, Alison, Nielsen, Douglas, Nisnisan, Josier, Nisnisan, Maria, Oden, Wendy, Orsak, Jessica, Ozer, Kerem, Papacostea, Olivia, Panchal, Ravi, Parikh, Manish, Parthiban, Beneta, Perrin, Brittney, Perkins, Harvonya, Poduri, Madhuri, Pop, Laurentiu, Portales, Nancy, Porter-Tucci, Linda, Postell, Sharon, Pucillo, Ronald, Reddy, Madhavi, Reddy, Rajneesh, Almodovar, Ramon Gilberto Reyes, Richard, Timiki, Richardson, Michele, Riesch, Louie, Rivera-Flores, Samuel, Rizvi, Abid, Rizvi, Samana, Rodas, Kristen, Rodgers, Mark, Roe, Erin, Rogers, Rebecca, Romero, Reina, Rooker-Morris, Leslie, Rosenstock, Julio, Sachson, Richard, Salcedo, Alfredo, Schill, Joseph, Schuh, Kristy, Schuster, Randall, Scribner, Anita, Shah, Arunkumar, Shaw, Stephanie, Shirley, Jefferey, Shook, Mindy, Siddiqui, Muhammad, Sims, Jamie, Singh, Kamalpreet, Skero, Jennifer, Smejdir, Debra, Stacey, Amy, Strzinek, Robert, Tan, Anjanette, Tayabali, Khadija, Tercero, Almundena, Terry, Jessica, Tinney, Irene, Toe, Florence, Toler, Sara, Tripathy, Devjit, Tumyan, Anna, Ulrich, Michelle, Underwood, Krissandra, Valdez, Christina, Valdivieso, April, Vanderheiden, Anna, Vandre, Morgan, Vardeman, Megan, Vargas, Richard, Vilchis, Monica, Warne, Desiree, Wallace, Jeannine, Weindorff, Kathleen, Welch, Heather, Wellmon, Brandy, Werntz, Gary, White, Leta, Williams, Tearani, Wilson, Maria, Wilson, Robyn, Wilson, Ronald, Wood, John, Wright, David, Yeatts, Rhonda, Zahir, Rezwana, Crockett, Becky, Fawson, Ashlee, Graham, Timothy, Mitchell, Zachary, Quinn, Sally, Reddy, Deepika, Rhudy, Jackson, Rosen, Priscilla, Shakespear, Kaylynn, Simmons, Debra, Turner, Ashley, Vanderhoof, Erin, Wahl, Matthew, Zubair, Imran, Algus, Michael, Gilbert, Matthew, Gorson, David, Marney, Annis, Rodriguez, Juan Pablo Perdomo, Roth, Marilynn, Scofield, Sheilah, Thottan, Anna, Bittorf, Margaret, Botros, Emad, Carpenter, Jeanette, Dashiell, Carie, Dimascio-Johnson, Nancy, Fredrickson, Sonja, Gruenther, M., Hall, Lisa, Hartman, Aaron, Hiner, Janette, Kelley, Donna, Kimmel, Melissa, Larrick, Laura, Lawson, Marie, Levy, James, Lewis, Teneshia, Lovell, Charles, Newby, James, Nichols, Michelle, O'Donnell, Philip, Orengo, Sheyla, Pecsok, Thomas, Reiss, Lind, Tarkington, Phillip, Yeatts, Donald, Zieve, Franklin, Ahmed, Imtiaz, Ali, Sajid, Anwar, Sami, Cathcart, Harold, Dawson, Lucia, Floresca, Rolando, Galvan, Ashley, Gardner, Timothy, Halsey, Kami, Hashmi, Farrukh, Hegel, Jackie, Landon, Megan, Moulton, Katlynn, Nand, Cheta, Sakic, Amra, Sevey, Brandie, Wilson, Bruce, Ahl, Scott, Blank, Robert, Coly, Gerard, Hoenig, Jennifer, Jain, Rajeev, Joseph, Elizabeth, Kasprzak, Debra, Kisiel, Lalaine, Maaske, Maurene, Manadhar, Smriti, Patel, Shailendra, Sickler, Whitney, Grp, D.E.V.O.T.E. Study, Acibadem University Dspace, Marso S.P., Mcguire D.K., Zinman B., Poulter N.R., Emerson S.S., Pieber T.R., Pratley R.E., Haahr P.-M., Lange M., Brown-Frandsen K., Moses A., Skibsted S., Kvist K., Buse J.B., and Buscemi S
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Insulin degludec ,Blood Glucose ,Male ,medicine.medical_treatment ,DEVOTE Study Group ,Insulin Glargine ,Type 2 diabetes ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,law.invention ,diabetes ,insulin ,0302 clinical medicine ,Randomized controlled trial ,law ,Cardiovascular Disease ,GLUCOSE CONTROL ,11 Medical and Health Sciences ,RISK ,COMPLICATIONS ,OUTCOMES ,Incidence ,General Medicine ,Middle Aged ,Insulin, Long-Acting ,VARIABILITY ,Cardiovascular Diseases ,diabetes mellitus ,Female ,Life Sciences & Biomedicine ,Human ,medicine.drug ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Aged ,Diabetes Mellitus, Type 2 ,Double-Blind Method ,Humans ,Hypoglycemia ,Hypoglycemic Agents ,Medicine (all) ,Bedtime ,Article ,EVENTS ,03 medical and health sciences ,HYPOGLYCEMIA ,Medicine, General & Internal ,Internal medicine ,Diabetes mellitus ,General & Internal Medicine ,medicine ,Intensive care medicine ,METAANALYSIS ,Science & Technology ,Hypoglycemic Agent ,Insulin glargine ,business.industry ,Insulin ,medicine.disease ,business ,BASAL INSULIN - Abstract
BACKGROUND Degludec is an ultralong-Acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-To-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. METHODS We randomly assigned 7637 patients with type 2 diabetes to receive either insulin degludec (3818 patients) or insulin glargine U100 (3819 patients) once daily between dinner and bedtime in a double-blind, treat-To-Target, event-driven cardiovascular outcomes trial. The primary composite outcome in the time-To-event analysis was the first occurrence of an adjudicated major cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) with a prespecified noninferiority margin of 1.3. Adjudicated severe hypoglycemia, as defined by the American Diabetes Association, was the prespecified, multiplicity-Adjusted secondary outcome. RESULTS Of the patients who underwent randomization, 6509 (85.2%) had established cardiovascular disease, chronic kidney disease, or both. At baseline, the mean age was 65.0 years, the mean duration of diabetes was 16.4 years, and the mean (±SD) glycated hemoglobin level was 8.4±1.7%; 83.9% of the patients were receiving insulin. The primary outcome occurred in 325 patients (8.5%) in the degludec group and in 356 (9.3%) in the glargine group (hazard ratio, 0.91; 95% confidence interval, 0.78 to 1.06; P
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- 2017
56. Prohibitin S-Nitrosylation Is Required for the Neuroprotective Effect of Nitric Oxide in Neuronal Cultures.
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Youyang Qu, Konrad, Csaba, Anderson, Corey, Liping Qian, Yin, Tina, Manfredi, Giovanni, Iadecola, Costantino, and Ping Zhou
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NITRIC oxide ,SCAFFOLD proteins ,MITOCHONDRIAL proteins ,ISCHEMIC preconditioning ,BRAIN injuries - Abstract
Prohibitin (PHB) is a critical protein involved in many cellular activities. In brain, PHB resides in mitochondria, where it forms a large protein complex with PHB2 in the inner TFmembrane, which serves as a scaffolding platform for proteins involved in mitochondrial structural and functional integrity. PHB overexpression at moderate levels provides neuroprotection in experimental brain injury models. In addition, PHB expression is involved in ischemic preconditioning, as its expression is enhanced in preconditioning paradigms. However, the mechanisms of PHB functional regulation are still unknown. Observations that nitric oxide (NO) plays a key role in ischemia preconditioning compelled us to postulate that the neuroprotective effect of PHB could be regulated by NO. Here, we test this hypothesis in a neuronal model of ischemia-reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress. Further, we demonstrate that NO post-translationally modifies PHB through protein S-nitrosylation and regulates PHB neuroprotective function, in a nitric oxide synthase-dependent manner. These results uncover the mechanisms of a previously unrecognized form of molecular regulation of PHB that underlies its neuroprotective function. [ABSTRACT FROM AUTHOR]
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- 2020
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57. Spatial genetic structure within a population of nine-banded armadillos in western Mississippi.
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Binns, Loren A, Loughry, W J, McDonough, Colleen M, and Anderson, Corey Devin
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ARMADILLOS ,WILDLIFE refuges ,QUADRUPLETS ,DNA ,LARVAL dispersal ,SPERM competition - Abstract
The nine-banded armadillo (Dasypus novemcinctus) is unique among mammals because females produce litters of genetically identical quadruplets via monozygotic polyembryony. This unusual form of reproduction could have profound impacts on the spatial genetic structure of populations of armadillos, but at present it is unclear whether littermates remain together as adults, or if sex-biased dispersal occurs. The goal of our study was to determine whether fine-scale spatial genetic structure (FSGS) within a population of armadillos diminishes with age (i.e., from juvenile to adult due to the dispersal of littermates away from one another), and if the degree of FSGS for a given age class differs between the sexes. We obtained genotype data at seven microsatellite DNA loci for 421 individuals in a wild population of armadillos inhabiting the Yazoo National Wildlife Refuge in western Mississippi. Correlogram analyses based on measures of spatial genetic autocorrelation showed weak but significant FSGS that was driven by positive spatial genetic autocorrelation among both male and female juveniles and adult males, but not adult females. Positive spatial genetic autocorrelation among adult males could be due to either female-biased dispersal or high variance in male reproductive success. Further work is required to discriminate between these two possibilities. [ABSTRACT FROM AUTHOR]
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- 2020
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58. Abstract 17137: Unmasking Pathological Mechanisms of Long QT Syndrome KCNH2 H70R Variant Using Human iPSC-Cardiomyocytes
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Feng, Li, primary, Kim, Gina, additional, Eichel, Catherine A, additional, Liu, Fang, additional, Lim, Evi, additional, Anderson, Corey L, additional, Orland, Kate M, additional, Zhang, Jianhua, additional, Eckhardt, Lee L, additional, Robertson, Gail A, additional, January, Craig T, additional, and Kamp, Timothy J, additional
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- 2018
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59. Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress
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Anderson, Corey J., primary, Kahl, Anja, additional, Qian, Liping, additional, Stepanova, Anna, additional, Starkov, Anatoly, additional, Manfredi, Giovanni, additional, Iadecola, Costantino, additional, and Zhou, Ping, additional
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- 2018
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60. Horse-and-Buggy Genius: Listening to Mennonites Contest the Modern World, by Royden Loewen, Winnipeg, MB: University of Manitoba Press, 2016. 256 pp. $27.95 (paper). ISBN: 9780887557989. Pennsylvania Dutch: The Story of an American Language, by Mark Loude
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Anderson, Corey, primary and Donnermeyer, Joseph, additional
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- 2018
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61. Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2
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Hall, Allison R., primary, Anderson, Corey L., additional, Smith, Jennifer L., additional, Mirshahi, Tooraj, additional, Elayi, Claude S., additional, January, Craig T., additional, and Delisle, Brian P., additional
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- 2018
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62. Vegetation density estimation in the wild
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Mihail, Radu P., primary, Cook, Wesley I., additional, Griffin, Brandi M., additional, Uyeno, Theodore A., additional, and Anderson, Corey D., additional
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- 2018
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63. Changes in IKR Amplitude (NOT Gating) is the Key Determinant for Ventricular Action Potential Prolongation
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Burgess, Don E., primary, Smith, Jennifer L., additional, Amin, Ahmad S., additional, Anderson, Corey L., additional, January, Craig T., additional, and Delisle, Brian P., additional
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- 2018
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64. AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis after ischemic stroke
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Kobayashi, Mariko, primary, Benakis, Corinne, additional, Anderson, Corey, additional, Moore, Michael J., additional, Poon, Carrie, additional, Uekawa, Ken, additional, Dyke, Jonathan P., additional, Fak, John J., additional, Mele, Aldo, additional, Park, Christopher Y., additional, Zhou, Ping, additional, Anrather, Josef, additional, Iadecola, Costantino, additional, and Darnell, Robert B., additional
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- 2018
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65. A Randomized Placebo-Controlled Trial of Varenicline for Smoking Cessation Allowing Flexible Quit Dates
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Rennard, Stephen, Hughes, John, Cinciripini, Paul M., Kralikova, Eva, Raupach, Tobias, Arteaga, Carmen, St Aubin, Lisa B., Russ, Cristina, Marta, Angueira, Elie, Fiss, Claude, Gagne, Helmersen, Douglas S., Ping, Chen, Rong Chang Chen, Chen, Wang, Czech, Beatrice Le Maitre, Isabelle, Schenkenberger, Iren, Herjavecz, Maria, Szilasi, Carrozzi, Laura, Rodolfo, Posadas, Ho Joong Kim, Young Whan Kim, Huey Shinn Cheng, Kuang Chieh Hsueh, Alex, Bobak, Anderson, Corey G., Borders, James L., Victor, Alan, Johnson, Gary E., Nabil Charle Morcos, Puopolo, Anthony D., Jon Andrew Shapiro, Sharp, Stephan C., Mark Edward Shirley, Tashkin, Donald P., and Vince, Bradley D.
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Placebo-controlled study ,Original Investigations ,Placebo ,Drug Administration Schedule ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Quinoxalines ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Nicotinic Agonists ,030212 general & internal medicine ,Adverse effect ,Varenicline ,Psychiatry ,business.industry ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,Odds ratio ,Benzazepines ,Middle Aged ,Tobacco Use Cessation Devices ,3. Good health ,Smoking Cessation ,Tobacco Use Cessation Products ,chemistry ,Smoking cessation ,Smoking ,Public Health ,business ,030217 neurology & neurosurgery - Abstract
INTRODUCTION: Current smoking cessation guidelines recommend setting a quit date prior to starting pharmacotherapy. However, providing flexibility in the date of quitting may be more acceptable to some smokers. The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication. METHODS: In this double-blind, randomized, placebo-controlled international study, smokers of ≥10 cigarettes/day, aged 18-75 years, and who were motivated to quit were randomized (3:1) to receive varenicline 1 mg b.i.d. or placebo for 12 weeks. Subjects were followed up through Week 24. Subjects were instructed to quit between Days 8 and 35 after starting medication. The primary endpoint was carbon monoxide-confirmed continuous abstinence during Weeks 9-12, and a key secondary endpoint was continuous abstinence during Weeks 9-24. RESULTS: Overall, 493 subjects were randomized to varenicline and 166 to placebo. Continuous abstinence was higher for varenicline than for placebo subjects at the end of treatment (Weeks 9-12: 53.1% vs. 19.3%; odds ratio [OR] 5.9; 95% CI, 3.7-9.4; p < .0001) and through 24 weeks follow-up (Weeks 9-24: 34.7% vs. 12.7%; OR 4.4; 95% CI, 2.6-7.5; p < .0001). Serious adverse events occurred in 1.2% varenicline (none were psychiatric) and 0.6% placebo subjects. Fewer varenicline than placebo subjects reported depression-related adverse events (2.3% vs. 6.7%, respectively). CONCLUSIONS: Varenicline 1 mg b.i.d. using a flexible quit date paradigm had similar efficacy and safety compared with previous fixed quit date studies. peerReviewed
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- 2011
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66. Neuronal expression of the mitochondrial protein prohibitin confers profound neuroprotection in a mouse model of focal cerebral ischemia
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Kahl, Anja, primary, Anderson, Corey J, additional, Qian, Liping, additional, Voss, Henning, additional, Manfredi, Giovanni, additional, Iadecola, Costantino, additional, and Zhou, Ping, additional
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- 2017
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67. Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists
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Joshi, Pramod, Anderson, Corey, Binch, Hayley, Hadida, Sabine, Yoo, Sanghee, Bergeron, Danielle, Decker, Caroline, terHaar, Ernst, Moore, Jonathan, Garcia-Guzman, Miguel, and Termin, Andreas
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- 2014
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68. Molecular pathogenesis of long QT syndrome type 2
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Smith, Jennifer L., primary, Anderson, Corey L., additional, Burgess, Don E., additional, Elayi, Claude S., additional, January, Craig T., additional, and Delisle, Brian P., additional
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- 2016
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69. Abstract 394: Multiple Cellular Mechanisms Underlie the Trafficking-deficient Phenotype for Kv11.1 (hERG) Mutations Linked to Long QT Syndrome
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Smith, Jennifer L, primary, Reloj, Allison R, additional, Anderson, Corey L, additional, January, Craig T, additional, and Delisle, Brian T, additional
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- 2016
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70. PATTERNS OF MYCOBACTERIUM LEPRAE INFECTION IN WILD NINE-BANDED ARMADILLOS (DASYPUS NOVEMCINCTUS) IN MISSISSIPPI, USA
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Perez-Heydrich, Carolina, primary, Loughry, W. J., additional, Anderson, Corey Devin, additional, and Oli, Madan K., additional
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- 2016
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71. Spatial Pattern Analysis
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Rosenberg, Michael, primary and Anderson, Corey, additional
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- 2016
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72. Trafficking Deficient KV11.1 (HERG) Mutations Linked to Long QT Syndrome Localize to Different Endoplasmic Reticulum Subcompartments
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Smith, Jennifer L., primary, Anderson, Corey L., additional, January, Criag T., additional, and Delisle, Brian, additional
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- 2016
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73. Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the -Encoded Kv11.1 Channel.
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Smith, Jennifer L., Tester, David J., Hall, Allison R., Burgess, Don E., Chun-Chun Hsu, Elayi, Samy Claude, Anderson, Corey L., January, Craig T., Luo, Jonathan Z., Hartzel, Dustin N., Mirshahi, Uyenlinh L., Murray, Michael F., Mirshahi, Tooraj, Ackerman, Michael J., Delisle, Brian P., Hsu, Chun-Chun, and Claude Elayi, Samy
- Abstract
Background: Heterologous functional validation studies of putative long-QT syndrome subtype 2-associated variants clarify their pathological potential and identify disease mechanism(s) for most variants studied. The purpose of this study is to clarify the pathological potential for rare nonsynonymous KCNH2 variants seemingly associated with sudden infant death syndrome.Methods: Genetic testing of 292 sudden infant death syndrome cases identified 9 KCNH2 variants: E90K, R181Q, A190T, G294V, R791W, P967L, R1005W, R1047L, and Q1068R. Previous studies show R181Q-, P967L-, and R1047L-Kv11.1 channels function similar to wild-type Kv11.1 channels, whereas Q1068R-Kv11.1 channels accelerate inactivation gating. We studied the biochemical and biophysical properties for E90K-, G294V-, R791W-, and R1005W-Kv11.1 channels expressed in human embryonic kidney 293 cells; examined the electronic health records of patients who were genotype positive for the sudden infant death syndrome-linked KCNH2 variants; and simulated their functional impact using computational models of the human ventricular action potential.Results: Western blot and voltage-clamping analyses of cells expressing E90K-, G294V-, R791W-, and R1005W-Kv11.1 channels demonstrated these variants express and generate peak Kv11.1 current levels similar to cells expressing wild-type-Kv11.1 channels, but R791W- and R1005W-Kv11.1 channels accelerated deactivation and activation gating, respectively. Electronic health records of patients with the sudden infant death syndrome-linked KCNH2 variants showed that the patients had median heart rate-corrected QT intervals <480 ms and none had been diagnosed with long-QT syndrome or experienced cardiac arrest. Simulating the impact of dysfunctional gating variants predicted that they have little impact on ventricular action potential duration.Conclusions: We conclude that these rare Kv11.1 missense variants are not long-QT syndrome subtype 2-causative variants and therefore do not represent the pathogenic substrate for sudden infant death syndrome in the variant-positive infants. [ABSTRACT FROM AUTHOR]- Published
- 2018
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74. Time-resolved stereo PIV measurements of the horseshoe vortex system at multiple locations in a low-aspect-ratio pin–fin array
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Anderson, Corey D., primary and Lynch, Stephen P., additional
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- 2015
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75. Abstract 16522: Structural Insights Into Destabilizing HERG PAS Domain Mutations Linked to Long Qt Syndrome
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Anderson, Corey L, primary, Kuzmicki, Catherine E, additional, Childs, Ryan R, additional, Hintz, Caleb J, additional, January, Craig T, additional, and Balijepalli, Ravi C, additional
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- 2015
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76. Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension
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Giles, Thomas D., primary, Bakris, George, additional, Oparil, Suzanne, additional, Weber, Michael A., additional, Li, Huiling, additional, Mallick, Madhuja, additional, Bharucha, David B., additional, Chen, ChunLin, additional, Ferguson, William G., additional, Sorin, John, additional, Davis, Matthew, additional, Izzo, Joesph, additional, Andrawis, Nabile, additional, Anderson, Alyn, additional, Bardinas-Rodriguez, Rogelio, additional, Young, Douglas, additional, Schreiber, Andrew, additional, Breton, Cristian, additional, Harris, Duane, additional, LaStella, Phillip, additional, Castello, Ramon, additional, Hole, Susan, additional, Lillo, Joesph, additional, Quintero, Luis Carlos, additional, Montenegro, Carlos, additional, Rosen, Jeffrey, additional, Marquez, Farid, additional, Adler, Fredric, additional, Alpizar, Sady, additional, Andersen, James, additional, Anderson, Corey, additional, Calatayud, Graciela, additional, Cannon, Kevin, additional, Cheung, Deanna, additional, Chiong, Rafel, additional, Cohen, Lisa, additional, Collins, Harry, additional, Dao, Michael, additional, Dawson, Cara H., additional, DeSantis, Donna, additional, Dunmyer, Shelly, additional, El-Harazi, Sherif, additional, Farrington, Cecil M., additional, Ferrera, David, additional, Funk, Gregory S., additional, Gottschlich, Gregory, additional, Hart, Terence T., additional, Kalafer, Marvin, additional, Kereiakes, Dean, additional, Lefebvre, Gigi, additional, Laliotis, Aristolis, additional, Mattar, Peter, additional, McCartney, Michael, additional, McConnehey, Diane, additional, Mello, Curtis, additional, Neutel, Joel, additional, Burke, Deborah A., additional, Pritchard, James, additional, Raad, George, additional, Rankin, Bruce, additional, Reed, John “Chip” H., additional, Schramm, Erich, additional, Schwartz, Howard, additional, Segall, Nathan, additional, Shoemaker, James, additional, Sial, Vakas, additional, Sligh, Teresa, additional, Smith, William, additional, Stewart, Richard, additional, Streja, Dan, additional, Sugimoto, Danny, additional, White, Alexander, additional, Williams, Hayes, additional, Abraham, William, additional, Ahmed, Azazuddin, additional, Beasley, Richard, additional, Gruener, Daniel, additional, Hsu, Connie, additional, Klein, Ryan, additional, Soo, Allen, additional, Andrews, Charles P., additional, Corder, Clinton, additional, Hurley, Donald, additional, Bretton, Elizabeth, additional, Martinez, Richard, additional, Morin, David, additional, Trevino, Miguel, additional, Arora, Samir, additional, Horn, Curtis Scott, additional, Lovell, Charles, additional, Nussdorfer, Thomas, additional, Weiss, Robert, additional, Bays, Harold, additional, Rhudy, Jackson, additional, Almaguer, Edwardo, additional, Woolley, Joseph H., additional, Miller, Vicki, additional, Moya-Hechevarria, Jaynier, additional, Punzi, Henry, additional, Taylor, Addison, additional, Wilson, Jonathan, additional, Alper, Arnold, additional, Buchanan, Patricia, additional, Dobrusin, Richard, additional, Forker, Alan, additional, Krumian, Razmig, additional, Oberstein, Samuel F., additional, Lewin, Andrew, additional, Natividad, Mary Bella, additional, Segui, Armando, additional, Harper, Wayne, additional, Lawless, Andrea, additional, Levinson, Lawrence S., additional, Shah, Shaukat, additional, Blair-Britt, Loray, additional, Carmichael, Patrick, additional, Giles, Thomas D., additional, Winer, Nathaniel, additional, Grant, David, additional, Rickner, Kyle, additional, Tilley, Absalom, additional, Harper, Linda, additional, Maddock, Stephen, additional, Boscia, Joseph A., additional, Khronusova, Yekaterina, additional, Reed, Larry D., additional, and Abboy, Chandar, additional
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- 2015
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77. Population Structure in the Roundtail Chub (Gila robusta Complex) of the Gila River Basin as Determined by Microsatellites: Evolutionary and Conservation Implications
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Dowling, Thomas E., primary, Anderson, Corey D., additional, Marsh, Paul C., additional, and Rosenberg, Michael S., additional
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- 2015
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78. Time Resolved Stereo-PIV Measurements of the Horseshoe Vortex System in a Low Aspect Ratio Pin-Fin Array
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Anderson, Corey, primary and Lynch, Stephen P., additional
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- 2015
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79. Interventions for Attention and Working Memory
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Anderson, Corey D., primary and Renee Anderson, J., additional
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80. Mouse ERG K + Channel Clones Reveal Differences in Protein Trafficking and Function
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Lin, Eric C., primary, Moungey, Brooke M., additional, Lim, Evi, additional, Concannon, Sarah P., additional, Anderson, Corey L., additional, Kyle, John W., additional, Makielski, Jonathan C., additional, Balijepalli, Sadguna Y., additional, and January, Craig T., additional
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- 2014
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81. Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome
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Anderson, Corey L., primary, Kuzmicki, Catherine E., additional, Childs, Ryan R., additional, Hintz, Caleb J., additional, Delisle, Brian P., additional, and January, Craig T., additional
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- 2014
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82. ChemInform Abstract: Addition of α-Lithiated Nitriles to Azaheterocycles.
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Anderson, Corey, primary, Moreno, Jesus, additional, and Hadida, Sabine, additional
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- 2014
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83. Corrigendum to “Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists” [Bioorg. Med. Chem. Lett. 24 (2014) 845–849]
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Joshi, Pramod, primary, Anderson, Corey, additional, Binch, Hayley, additional, Hadida, Sabine, additional, Yoo, Sanghee, additional, Bergeron, Daniele, additional, Decker, Caroline, additional, terHaar, Ernst, additional, Moore, Jonathan, additional, Garcia-Guzman, Miguel, additional, and Termin, Andreas, additional
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- 2014
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84. Addition of α-Lithiated Nitriles to Azaheterocycles
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Anderson, Corey, primary, Moreno, Jesus, additional, and Hadida, Sabine, additional
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- 2014
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85. Pharmacological correction of long QT-linked mutations inKCNH2(hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum
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Smith, Jennifer L., primary, Reloj, Allison R., additional, Nataraj, Parvathi S., additional, Bartos, Daniel C., additional, Schroder, Elizabeth A., additional, Moss, Arthur J., additional, Ohno, Seiko, additional, Horie, Minoru, additional, Anderson, Corey L., additional, January, Craig T., additional, and Delisle, Brian P., additional
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- 2013
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86. Synthesis of 2-Aminooxazolines and Spiro-2-aminooxazolines by Using a Convenient Two-Step INCO-Mediated Reaction
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Termin, Andreas, primary, Anderson, Corey, additional, Wilson, Dean, additional, Mao, Long, additional, Ramirez-Weinhouse, Michele, additional, Long, Daniel, additional, Crane, Christine, additional, Jolivet, Catherine, additional, Fanning, Dewey, additional, and Molteni, Valentina, additional
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- 2013
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87. Spectrophotometric determination of sperm concentration and short-term cold-storage of sperm in Atlantic croakerMicropogonias undulatusL. broodstock
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Leclercq, Eric, primary, Antoni, Luca, additional, Bardon-Albaret, Agnès, additional, Anderson, Corey R, additional, Somerset, Carly R, additional, and Saillant, Eric A, additional
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- 2012
- Full Text
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88. PASSaGE: Pattern Analysis, Spatial Statistics and Geographic Exegesis. Version 2
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Rosenberg, Michael S., primary and Anderson, Corey Devin, additional
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- 2010
- Full Text
- View/download PDF
89. Primary Benign Interatrial Schwannoma Encountered during Aortic Valve Replacement
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Anderson, Corey D., primary, Hashimi, Samad, additional, Brown, Talitha, additional, Moyers, John, additional, and Farivar, Robert Saeid, additional
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- 2010
- Full Text
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90. Comparison of mERG and hERG Clones Reveals Differences in Protein Trafficking and Functionality: Structural Implications
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Lin, Eric C., primary, Moungey, Brooke M., additional, Lim, Evi, additional, Anderson, Corey L., additional, Balijepalli, Sadguna Y., additional, and January, Craig T., additional
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- 2010
- Full Text
- View/download PDF
91. Considering spatial and temporal scale in landscape‐genetic studies of gene flow
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ANDERSON, COREY DEVIN, primary, EPPERSON, BRYAN K., additional, FORTIN, MARIE‐JOSÉE, additional, HOLDEREGGER, ROLF, additional, JAMES, PATRICK M. A., additional, ROSENBERG, MICHAEL S., additional, SCRIBNER, KIM T., additional, and SPEAR, STEPHEN, additional
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- 2010
- Full Text
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92. Rescue of Mutated Cardiac Ion Channels in Inherited Arrhythmia Syndromes
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Balijepalli, Sadguna Y, primary, Anderson, Corey L, additional, Lin, Eric C, additional, and January, Craig T, additional
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- 2010
- Full Text
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93. Informed Consent
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Miller, Catherine, primary and Anderson, Corey, additional
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- 2010
- Full Text
- View/download PDF
94. The Role of Cytoprotective Cytokines in Cardiac Ischemia/Reperfusion Injury
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Anderson, Corey D., primary, Heydarkhan-Hagvall, Sepideh, additional, Schenke-Layland, Katja, additional, Yang, Jin Quan, additional, Jordan, Maria C., additional, Kim, Jeanne K., additional, Brown, David A., additional, Zuk, Patricia A., additional, Laks, Hillel, additional, Roos, Kenneth P., additional, MacLellan, W. Robb, additional, and Beygui, Ramin E., additional
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- 2008
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95. Cell-free complements in vivo expression of theE. colimembrane proteome
- Author
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Savage, David F., primary, Anderson, Corey L., additional, Robles-Colmenares, Yaneth, additional, Newby, Zachary E., additional, and Stroud, Robert M., additional
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- 2007
- Full Text
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96. HYDROLYTIC SELECTIVITY OF PATATIN (LIPID ACYL HYDROLASE) FROM POTATO (SOLANUM TUBEROSUM L.) TUBERS TOWARD VARIOUS LIPIDS
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ANDERSON, COREY, primary, PINSIRODOM, PRAPHAN, additional, and PARKIN, KIRK L., additional
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- 2007
- Full Text
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97. Clinical Practice versus Field Surgery: A Discussion of the Regulations and Logistics of Implanting Radiotransmitters in Snakes
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ANDERSON, COREY DEVIN, primary and TALCOTT, MICHAEL, additional
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- 2006
- Full Text
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98. Utility of a set of microsatellite primers developed for the massasauga rattlesnake (Sistrurus catenatus) for population genetic studies of the timber rattlesnake (Crotalus horridus)
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ANDERSON, COREY DEVIN, primary
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- 2006
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99. Most LQT2 Mutations Reduce Kv11.1 (hERG) Current by a Class 2 (Trafficking-Deficient) Mechanism
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Anderson, Corey L., primary, Delisle, Brian P., additional, Anson, Blake D., additional, Kilby, Jennifer A., additional, Will, Melissa L., additional, Tester, David J., additional, Gong, Qiuming, additional, Zhou, Zhengfeng, additional, Ackerman, Michael J., additional, and January, Craig T., additional
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- 2006
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100. The inner pore mutation Y652C reverses the trafficking-defective Long QT2 channels G601S and F640V phenotype
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Delisle, Brian, Slind, Jessica, Kilby, Jennifer, Anderson, Corey L., Tester, David J., Ackerman, Michael J., Balije-Palli, Ravi C., Kamp, Timothy J., and January, Craig T.
- Subjects
Ion channels -- Research ,Ion channels -- Physiological aspects ,Human physiology -- Research ,Long QT syndrome ,Biological sciences ,Health - Abstract
Several mutations in the human ether-a-go-go-related gene (HERG of KCNH2)-encoded [K.sup.+] channel disrupt intracellular ion channel transport (trafficking) and cause long QT syndrome (LQT2). Compared with WT HERG, trafficking-defective LQT2 channels have a phenotype of minimal of absent complex glycosylation and poor surface membrane expression. We report a novel HERG mutation in the sixth transmembrane segment (F640V) in a family with a history of sudden death, syncope, and long QT syndrome. Heterologous expression of F640V showed a trafficking-defective phenotype, and this phenotype was corrected by a 24-h incubation in the HERG channel blocker E4031(10 mM). We then tested the hypothesis that mutating the putative drug-binding domain at position Y652 would alter the effect of E4031. In a WT background, the Y652C mutation did not alter the WT glycosylation pattern but reduced [I.sub.HERG] (WT = 108 [+ or -] 20pA/pF, n = 9; Y652C 31 [+ or -] 8pA/pF, n = 6), presumably by altering channel function. Y652C [I.sub.HERG] also was less sensitive than WT to E4031(100 nM) block; [I.sub.HERG] WT = 17 + 1% (n = 5) and Y652C = 78 [+ or -] 3% (n = 3). We next tested the double mutation F640V-Y652C. In contrast to F640V, F640V-Y652C was complexly glycosylated; confocal microscopy confirmed cell surface expression; and [I.sub.HERG] was increased (F640V = 8 [+ or -] 1 pA/pF, n = 13; F640V-Y652C = 22 [+ or -] 2 pA/pF, n = 10) to a level similar to Y652C alone. We also tested the trafficking-defective G601S mutation and obtained similar findings; G601S-Y652C was complexly glycosylated and [I.sub.HERG] density was comparable to that of Y652C alone (G601S = 39 [+ or -] 8 pA/pF, n = 6; G601S-Y652C = 25 [+ or -] 7 pA/pF, n = 5). E4031 (10 [micro]M) incubation (24 h) did not alter the glycosylation pattern or [I.sub.HERG] in F640V-Y652C of G601S-Y652C. We conclude that mutagenic modification of the inner pore can restore the processing of several trafficking-defective LQT2 channel proteins. (Supported in part by RO1 HL60723 to Craig T. January and F32 HL071476-01 to Brian Delisle.)
- Published
- 2004
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