174 results on '"Ancelle T"'
Search Results
52. Randomized trial of albendazole versus tiabendazole plus flubendazole during an outbreak of human trichinellosis
- Author
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Fouresti�, V., primary, Bougnoux, M. E., additional, Ancelle, T., additional, Liance, M., additional, Roudot-Thoraval, F., additional, Naga, H., additional, Pairon-Pennachioni, M., additional, Rauss, A., additional, and Lejonc, J. L., additional
- Published
- 1988
- Full Text
- View/download PDF
53. Experimental trichinellosis in horses: Biological and parasitological evaluation
- Author
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Soule, C., primary, Dupouy-Camet, J., additional, Georges, P., additional, Ancelle, T., additional, Gillet, J.P., additional, Vaissaire, J., additional, Delvigne, A., additional, and Plateau, E., additional
- Published
- 1989
- Full Text
- View/download PDF
54. A propos de 1159 cas de Bilharzioses
- Author
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Lapierre, J., primary, Holler, C., additional, Tourte-Schaefer, C., additional, Ancelle, T., additional, Vinh Hien, Tran, additional, Roose, A., additional, Megard, M., additional, Timbard, M.F., additional, and Contin, J., additional
- Published
- 1978
- Full Text
- View/download PDF
55. Sensibilité aux antifongiques de 200 souches de levure isolées de prélevements profonds en milieu hospitalier
- Author
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Dupouy-Camet, J., primary, Ancelle, T., additional, Bougnoux, M.E., additional, and Lapierre, J., additional
- Published
- 1984
- Full Text
- View/download PDF
56. Antigenic characteristics of two strains of Trichinella spiralis isolated during the horsemeat-related outbreaks of 1985 in France.
- Author
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Dupouy-Camet, J., Bougnoux, M., Ancelle, T., Fagard, R., and Lapierre, J.
- Published
- 1988
- Full Text
- View/download PDF
57. Persistence of antibodies to Trypanosoma brucei gambiense after treatment of human trypanosomiasis in Uganda.
- Author
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Paquet, C, Ancelle, T, Gastellu-Etchegorry, M, Castilla, J, and Harndt, I
- Subjects
- *
ANIMAL experimentation , *COMPARATIVE studies , *IMMUNOGLOBULINS , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *PROTOZOA , *RESEARCH , *TRYPANOSOMIASIS , *EVALUATION research - Published
- 1992
- Full Text
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58. Neurotrichinosis: A cerebrovascular disease associated with myocardial injury and hypereosinophilia
- Author
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Fourestie, V., Douceron, H., Brugieres, P., Ancelle, T., Lejonc, J. L., and Gherardi, R. K.
- Abstract
The clinical features, brain computerized tomography (CT) scans and cardiological findings of nine patients with neurotrichinosis are reviewed. Neurological signs consisted of encephalopathy and focal deficits with small hypodensities in the cortex and white matter, detected by the CT scans. Various cardiovascular events were also observed in eight out of nine patients. They were usually concomitant with neurological symptoms and mainly consisted of myocardial injury as assessed by electrocardiographic and plasma creatine phosphokinase (CPK)-MB isoenzyme changes. The cardio-neurological syndrome developed early in the course of the disease at a time of marked hypereosinophilia and the percentage of patients with eosinophilia >4000 mm3 was significantly higher in the patients with neurological dysfunction than in those without neurological signs. We selected the following criteria to describe the distinctive cardio-neurological syndrome related to trichinosis: (i) early onset of neurological symptoms (within a few days) after the first general symptoms; (ii) central nervous system involvement consisting of both diffuse encephalopathy and focal neurological deficits, usually of simultaneous onset; (iii) concomitant acute myocardial injury and/or infarction; (iv) marked hypereosinophilia (>4000/mm3 at time of first cardio-neurological events; (v) brain CT scan showing small hypodensities in the hemispheric white matter or cortex. Post-mortem examination of one patient revealed ischaemic lesions with multiple arteriolar microthrombi in the brain and myocardium. This was consistent with the brain CT scan and electrocardiographic data and suggested that neurotrichinosis is an expression of a multi-organ disorder associated with hypereosinophilia, that is characterized in most patients by simultaneous neurological and myocardial manifestations basically related to ischaemia.
- Published
- 1993
- Full Text
- View/download PDF
59. Les maladies du voyage et d'importation
- Author
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Fouque, F., Fontenille, Didier, and Ancelle, T. (coord.)
- Subjects
EPIDEMIOLOGIE ,TOURISME ,MALADIE ,TRANSMISSION ,VECTEUR ,INTRODUCTION D'ESPECES ,SANTE PUBLIQUE ,ECHANGE COMMERCIAL ,PORT ,AGENT PATHOGENE - Published
- 2011
60. Longer incubation times for yeast fungemia: importance for presumptive treatment.
- Author
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Paugam A, Ancelle T, Lortholary O, and Bretagne S
- Subjects
- Humans, Time Factors, Antifungal Agents therapeutic use, Candida glabrata isolation & purification, Cryptococcus neoformans isolation & purification, Fungemia diagnosis, Fungemia drug therapy
- Abstract
Isolation rates of Candida glabrata at ≤2 days were 8.9% and 34.8% at >2 days; for Cryptococcus neoformans, they were 0.9% and 8.6%, respectively (1741 fungemia analyzed). An incubation time >2 days supports candins as presumptive treatment for C. glabrata, keeping in mind the risk of Cryptococcus fungemia., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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61. Safety and immunogenicity of yellow fever 17D vaccine in adults receiving systemic corticosteroid therapy: an observational cohort study.
- Author
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Kernéis S, Launay O, Ancelle T, Iordache L, Naneix-Laroche V, Méchaï F, Fehr T, Leroy JP, Issartel B, Dunand J, van der Vliet D, Wyplosz B, Consigny PH, and Hanslik T
- Subjects
- Adrenal Cortex Hormones adverse effects, Adult, Arthralgia chemically induced, Arthralgia immunology, Cohort Studies, Fatigue chemically induced, Fatigue immunology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Surveys and Questionnaires, Yellow Fever epidemiology, Yellow Fever Vaccine adverse effects, Yellow fever virus immunology, Adrenal Cortex Hormones administration & dosage, Yellow Fever immunology, Yellow Fever prevention & control, Yellow Fever Vaccine immunology, Yellow Fever Vaccine therapeutic use
- Abstract
Objective: To assess the safety and immunogenicity of live attenuated yellow fever (YF) 17D vaccine in adults receiving systemic corticosteroid therapy., Methods: All adult travelers on systemic corticosteroid therapy who had received the YF17D vaccine in 24 French vaccination centers were prospectively enrolled and matched with healthy controls (1:2) on age and history of YF17D immunization. Safety was assessed in a self-administered standardized questionnaire within 10 days after immunization. YF-specific neutralizing antibody titers were measured 6 months after vaccination in patients receiving corticosteroids., Results: Between July 2008 and February 2011, 102 vaccine recipients completed the safety study (34 receiving corticosteroids and 68 controls). The median age was 54.9 years (interquartile range [IQR] 45.1-60.3 years) and 45 participants had a history of previous YF17D immunization. The median time receiving corticosteroid therapy was 10 months (IQR 1-67 months) and the prednisone or equivalent dosage was 7 mg/day (IQR 5-20). Main indications were autoimmune diseases (n = 14), rheumatoid arthritis (n = 9), and upper respiratory tract infections (n = 8). No serious adverse event was reported; however, patients receiving corticosteroids reported more frequent moderate/severe local reactions than controls (12% and 2%, respectively; relative risk 8.0, 95% confidence interval 1.4-45.9). All subjects receiving corticosteroids who were tested (n = 20) had neutralizing antibody titers >10 after vaccination., Conclusion: After YF17D immunization, moderate/severe local reactions may be more frequent in patients receiving systemic corticosteroid therapy. Immunogenicity seems satisfactory. Large-scale studies are needed to confirm these results., (Copyright © 2013 by the American College of Rheumatology.)
- Published
- 2013
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62. Severe imported Plasmodium falciparum malaria, France, 1996-2003.
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Seringe E, Thellier M, Fontanet A, Legros F, Bouchaud O, Ancelle T, Kendjo E, Houze S, Le Bras J, Danis M, and Durand R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, France epidemiology, Humans, Infant, Infant, Newborn, Male, Middle Aged, Retrospective Studies, Risk Factors, Travel, Young Adult, Malaria, Falciparum epidemiology, Population Surveillance
- Abstract
Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease is not endemic because most studies have been case reports or have included <200 patients. To identify factors independently associated with the severity of P. falciparum, we conducted a retrospective study using surveillance data obtained from 21,888 P. falciparum patients in France during 1996-2003; 832 were classified as having severe malaria. The global case-fatality rate was 0.4% and the rate of severe malaria was ≈3.8%. Factors independently associated with severe imported P. falciparum malaria were older age, European origin, travel to eastern Africa, absence of chemoprophylaxis, initial visit to a general practitioner, time to diagnosis of 4 to 12 days, and diagnosis during the fall-winter season. Pretravel advice should take into account these factors and promote the use of antimalarial chemoprophylaxis for every traveler, with a particular focus on nonimmune travelers and elderly persons.
- Published
- 2011
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63. Congenital toxoplasmosis in France in 2007: first results from a national surveillance system.
- Author
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Villena I, Ancelle T, Delmas C, Garcia P, Brezin AP, Thulliez P, Wallon M, King L, and Goulet V
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- Abortion, Induced, Female, Fetal Death, France epidemiology, Gestational Age, Humans, Incidence, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical prevention & control, Male, Maternal Age, Population Surveillance, Pregnancy, Prenatal Diagnosis, Prevalence, Risk Factors, Toxoplasmosis, Congenital prevention & control, Toxoplasmosis, Congenital transmission, Pregnancy Complications, Parasitic epidemiology, Toxoplasma isolation & purification, Toxoplasmosis, Congenital epidemiology
- Abstract
When immunocompetent people become infected with the parasite Toxoplasma gondii, the disease is generally asymptomatic. However, transplacental transmission of T. gondii may lead to severe congenital infection including in utero abortion, foetal death, or neurological or ocular damage of the foetus. France has had a national programme to prevent congenital toxoplasmosis since 1978. However, although estimated seroprevalence in pregnant women has fallen from 84% in the 1960s to 44% in 2003, no reliable data have been available on the annual number of cases of congenital toxoplasmosis or the severity of infection. In 2006, the French National Institute for Public Health Surveillance (Institut de Veille Sanitaire) and the National Reference Centre for Toxoplasmosis recommended that a national laboratory-based surveillance system be used for the surveillance of the disease. In 2007, 31 laboratories reported at least one congenital case through the surveillance system, giving a total of 272 cases. A total of 11 terminations of pregnancy were reported (six abortions and five foetal deaths). Of the live-born cases, 206 were asymptomatic, 28 were symptomatic and seven had a severe form of the disease. As there were 818,700 births in France and French overseas departments in 2007, the overall prevalence of congenital toxoplasmosis observed that year was 3.3 (95% confidence interval (CI): 2.9 to 3.7) per 10,000 live births and the incidence rate of the disease at birth was 2.9 (95% CI: 2.5 to 3.2) per 10,000 live births; the estimated incidence rate of symptomatic congenital toxoplasmosis was 0.34 (95% CI: 0.2 to 0.5) cases per 10,000 live births.
- Published
- 2010
- Full Text
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64. [Trichinellosis].
- Author
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Dupouy-Camet J, Talabani H, and Ancelle T
- Subjects
- France, Humans, Trichinellosis complications, Trichinellosis therapy
- Abstract
Trichinellosis is a parasitic zoonosis caused by several species of the viviparous nematode of the genus Trichinella. Trichinellosis is a food borne zoonosis and can be contracted by eating raw or rare meat. This disease can be prevented by domestic and public health measures. France has thus considerably reinforced its system of prevention at slaughterhouses and in 2002 a Trichinella National Reference Centre was implemented. Trichinellosis is considered as a re-emergent disease throughout the world and more than 2500 cases have been reported in France since 1975. The possible severe neurological and cardiovascular complications, the risk of death highlight the need for a better knowledge of the disease and of its impact on public health.
- Published
- 2010
65. [How can the cost of screening for toxoplasmosis during pregnancy be reduced?].
- Author
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Ancelle T, Yera H, Talabani H, Lebuisson A, Thulliez P, and Dupouy-Camet J
- Subjects
- Antibodies, Protozoan blood, Female, France epidemiology, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Pregnancy, Pregnancy Complications, Parasitic epidemiology, Seroepidemiologic Studies, Toxoplasmosis epidemiology, Toxoplasmosis immunology, Mass Screening economics, Pregnancy Complications, Parasitic diagnosis, Toxoplasmosis diagnosis
- Abstract
Background: A program of systematic serology screening for toxoplasmosis during pregnancy has been running in France since 1978. The program involves monthly follow-ups for all non-immune pregnant women. Due to the steady decline in the seroprevalence of toxoplasmosis, the cost of the program is steadily increasing. Current screening is based on the detection of IgG and IgM isotypes. The aim of this work was to estimate the benefit of replacing combined dosage of two isotypes, by an alternative strategy that detects total anti-Toxoplasma immunoglobulins., Methods: The rate of decreasing seroprevalence and the increasing burden on serological examinations was measured in a study population of pregnant women who were checked for toxoplasmosis by the parasitology laboratory of the Cochin Hospital, Paris. The increase in screening costs was estimated for the all-pregnant women and the expected benefits stemming from simply measuring total anti-Toxoplasma immunoglobulins compared to the double IgG-IgM assay were estimated., Results: Between 1987 and 2008, the seroprevalence of toxoplasmosis measured at the Cochin hospital dropped from 70.8% to 48.6% with a 1.77% annual rate of decline. This downward trend is similar to that observed by the national perinatal surveys performed in 1995 and in 2003. As the number of non-immune women to follow-up each month is constantly increasing, the proportion of negative tests issued reached 87.6% in 2008. Extrapolating these results to the whole of France, we estimated that the number of required screening tests perform was increasing by 93,000 units per year with an additional associated cost of one million euros. Various alternative scenarios of antibody detection are proposed that could save between 40.2% and 48.4% of current screening costs., Conclusion: Replacement of combined dosage of IgG and IgM isotypes by determination of just total Ig would significantly reduce costs of toxoplasmosis screening for pregnant women, without effecting either the general strategy, or proven efficiency of the national program.
- Published
- 2009
- Full Text
- View/download PDF
66. [Antiviral immunization of immunocompromised adults, literature review].
- Author
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Duchet Niedziolka P, Launay O, Salmon Ceron D, Consigny PH, Ancelle T, Van der Vliet D, Lortholary O, and Hanslik T
- Subjects
- AIDS Vaccines adverse effects, AIDS Vaccines therapeutic use, Adult, Chickenpox Vaccine adverse effects, Chickenpox Vaccine therapeutic use, Hepatitis A Vaccines adverse effects, Hepatitis A Vaccines therapeutic use, Humans, Safety, Viral Vaccines adverse effects, Yellow Fever Vaccine adverse effects, Yellow Fever Vaccine therapeutic use, Immunization methods, Immunocompromised Host immunology, Viral Vaccines therapeutic use
- Abstract
Purpose: Immunization, by preventing infections, has a major interest for the immunocompromised subjects. The aim of this article is to make a point on data concerning efficacy (in terms of immunogenicity) and safety of viral vaccines available in France and to synthesize existing guidelines for four groups of patients: solid organ and hematopoietic stem cell transplant recipients, HIV infected persons and patients treated by immunosuppressive drugs for a systemic disease., Current Knowledge and Key Points: Available data about vaccines immunogenicity and safety for immunocompromised adults are rare. However, those data indicate that, when immunization contraindications and recommendations are applied, vaccines remain well tolerated and most of the time immunogenic, even if the percentage of responders is lower compared to non immunocompromised persons. Still, the specific guidelines that have been elaborated for immunization of immunocompromised adults are imprecise and incomplete, emphasizing a lack of data about this topic., Future Prospects: Clinical studies remain necessary to precise vaccines immunogenicity and safety for immunocompromised adults. In the meantime, a harmonization of immunization practices for immunocompromised adults should be proposed, so as to help practitioners to succeed a better immunization coverage for these patients.
- Published
- 2008
- Full Text
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67. Risk factors for imported fatal Plasmodium falciparum malaria, France, 1996-2003.
- Author
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Legros F, Bouchaud O, Ancelle T, Arnaud A, Cojean S, Le Bras J, Danis M, Fontanet A, and Durand R
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- Adolescent, Adult, Africa ethnology, Age Factors, Aged, Aged, 80 and over, Antibiotic Prophylaxis, Child, Child, Preschool, Emigration and Immigration, Female, France epidemiology, Humans, Male, Middle Aged, Mortality, Odds Ratio, Retrospective Studies, Risk Assessment, Endemic Diseases, Malaria, Falciparum mortality, Travel
- Abstract
Plasmodium falciparum malaria is a serious health hazard for travelers to malaria-endemic areas and is often diagnosed on return to the country of residence. We conducted a retrospective study of imported falciparum malaria among travelers returning to France from malaria-endemic areas from 1996 through 2003. Epidemiologic, clinical, and parasitologic data were collected by a network of 120 laboratories. Factors associated with fatal malaria were identified by logistic regression analysis. During the study period, 21,888 falciparum malaria cases were reported. There were 96 deaths, for a case-fatality rate of 4.4 per 1,000 cases of falciparum malaria. In multivariate analysis, risk factors independently associated with death from imported malaria were older age, European origin, travel to East Africa, and absence of chemoprophylaxis. Fatal imported malaria remains rare and preventable. Pretravel advice and malaria management should take into account these risk factors, particularly for senior travelers.
- Published
- 2007
- Full Text
- View/download PDF
68. Human trichinellosis acquired from wild boar meat: a continuing parasitic risk in France.
- Author
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De Bruyne A, Ancelle T, Vallee I, Boireau P, and Dupouy-Camet J
- Subjects
- Animals, Disease Outbreaks prevention & control, Food Handling methods, Foodborne Diseases parasitology, Foodborne Diseases prevention & control, France epidemiology, Humans, Trichinella isolation & purification, Trichinellosis diagnosis, Trichinellosis prevention & control, Foodborne Diseases epidemiology, Meat parasitology, Sus scrofa parasitology, Trichinellosis epidemiology
- Published
- 2006
- Full Text
- View/download PDF
69. Outbreak of trichinellosis due to consumption of bear meat from Canada, France, September 2005.
- Author
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Ancelle T, De Bruyne A, Poisson D, and Dupouy-Camet J
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- Adult, Aged, Animals, Canada epidemiology, Commerce, Female, France epidemiology, Humans, Incidence, Male, Middle Aged, Risk Factors, Ursidae, Disease Outbreaks statistics & numerical data, Food Contamination statistics & numerical data, Foodborne Diseases epidemiology, Meat statistics & numerical data, Population Surveillance, Risk Assessment methods, Trichinellosis epidemiology
- Published
- 2005
- Full Text
- View/download PDF
70. [Human bothriocephaliasis is always present in France (Survey conducted in Haute-Savoie between 1993 and 2000)].
- Author
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Desvois L, Grégory A, Ancelle T, and Dupouy-Camet J
- Subjects
- Animals, Cestode Infections parasitology, Cestode Infections transmission, Eosinophilia epidemiology, Eosinophilia parasitology, Fishes parasitology, Food Contamination, Food Handling, Food Parasitology, France epidemiology, Health Surveys, Humans, Intestinal Diseases, Parasitic parasitology, Intestinal Diseases, Parasitic transmission, Occupational Diseases epidemiology, Occupational Diseases parasitology, Restaurants, Cestoda isolation & purification, Cestode Infections epidemiology, Intestinal Diseases, Parasitic epidemiology
- Published
- 2002
71. Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases.
- Author
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Robert-Gangneux F, Gavinet MF, Ancelle T, Raymond J, Tourte-Schaefer C, and Dupouy-Camet J
- Subjects
- Animals, Antibodies, Protozoan blood, Blotting, Western, Female, Fetal Blood parasitology, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Mice, Placenta parasitology, Pregnancy, Retrospective Studies, Prenatal Diagnosis, Toxoplasmosis, Congenital diagnosis
- Abstract
We reviewed the files of 110 women with Toxoplasma seroconversion during pregnancy. Prenatal diagnosis was attempted for 94 women by amniotic fluid sampling. Toxoplasma gondii was detected by PCR, with or without tissue culture and mouse inoculation. The early neonatal diagnostic procedure included placental testing by PCR and/or mouse inoculation, cord blood serological testing, and comparison of maternal and newborn antibodies by Western blotting (WB). Serological follow-up of the infants was conducted during the first year of life or until the diagnosis of congenital toxoplasmosis (CT) could be ruled out. Congenital infection was diagnosed in 27 individuals (20 live births) in the prenatal and/or neonatal period. The sensitivity and specificity of prenatal diagnosis were 81 and 100%, respectively. Placental examination was positive for 66.7% of individuals with CT and was always negative for neonates without CT. Cord blood serology detected immunoglobulin M (IgM) and/or IgA in 80% of infected newborns, with respective specificities of 91.2 and 87.7%. By WB we detected bands on IgG and IgM blots recognized by the newborn serum but not by the maternal serum (neosynthesized IgG and/or IgM) for 88.2% of infected infants within the first 2 months of life with a specificity of 100%. Early postnatal diagnosis was negative for 2 of the 20 neonates with CT. Both of these newborns had a negative prenatal diagnosis and were asymptomatic, suggesting a very low parasite load. In conclusion, despite the use of advanced methods, some cases of congenital toxoplasmosis cannot be detected early, which underlines the importance of careful follow-up of newborns who are at risk.
- Published
- 1999
- Full Text
- View/download PDF
72. Risk factors for Toxoplasma infection in pregnancy: a case-control study in France.
- Author
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Baril L, Ancelle T, Goulet V, Thulliez P, Tirard-Fleury V, and Carme B
- Subjects
- Adult, Animals, Antibodies, Protozoan blood, Case-Control Studies, Cats, Cooking, Diet, Female, France epidemiology, Hand Disinfection, Humans, Hygiene, Meat, Pregnancy, Pregnancy Complications, Parasitic epidemiology, Pregnancy Complications, Parasitic prevention & control, Risk Factors, Toxoplasma immunology, Toxoplasmosis epidemiology, Toxoplasmosis prevention & control, Pregnancy Complications, Parasitic etiology, Toxoplasmosis etiology
- Abstract
Each year an estimated 4900 cases of primary Toxoplasma infection occur in pregnant women in France, a country with a high prevalence. Since 1992 all pregnant women at risk of Toxoplasma infection have been required to undergo monthly serological testing. This case-control study, the first of its kind in France, was undertaken to identify risk factors for Toxoplasma infection during pregnancy, with a view to improving primary prevention among non-immune pregnant women. A total of 80 pregnant women who seroconverted to Toxoplasma were matched with 80 pregnant women who had repeatedly negative tests. The women were interviewed by telephone, using a standardized questionnaire, to determine socio-demographic characteristics, exposure to possible risk factors and the type of information on prevention received during pregnancy. The risk factors for Toxoplasma infection included in a multivariate analysis were poor hand hygiene (OR = 9.9; 95%CI: 0.8-125), consumption of undercooked beef (OR = 5.5; 95%CI: 1.1-27), having a pet cat (OR =4.5; 95%CI: 1.0-19.9), frequent consumption of raw vegetables outside the home (OR = 3.1; 95%,CI: 1.2-7.7) and consumption of undercooked lamb (OR = 3.1; 95%CI: 0.85-14). Receipt of documentary advice on prevention was associated with a lower risk of infection. Prevention campaigns among pregnant women in France could be improved and should focus on eating habits, hand hygiene and cats.
- Published
- 1999
- Full Text
- View/download PDF
73. Outbreak of trichinosis in France associated with eating horse meat.
- Author
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Laurichesse H, Cambon M, Perre D, Ancelle T, Mora M, Hubert B, Beytout J, and Rey M
- Subjects
- Adult, Animals, Case-Control Studies, Female, Food Inspection, France, Horses, Humans, Male, Disease Outbreaks, Meat parasitology, Trichinellosis etiology
- Abstract
The investigation of a trichinosis outbreak in Auvergne, France identified 23 cases in 12 households living in two cities-Clermont-Ferrand and Montluçon-between 15 February and 7 March 1991. One patient required intensive care, 15 had major symptoms, and seven had minor or no symptoms. Two case control studies demonstrated a significant (p < 0.01) association between eating horse meat and acute trichinosis. Veterinary services found that three supermarkets where the patients had bought horse meat during the suspected period had been supplied by a single wholesaler. The analysis of the wholesaler's records revealed that the implicated horse meat had been imported from a slaughterhouse in the United States. This outbreak occurred despite a requirement in France for all meat from horses slaughtered in France and in countries exporting meat to France to be examined systematically for trichinella.
- Published
- 1997
74. [Detection of trypanosomes in blood by the Quantitative Buffy Coat (QBC) technique: experimental evaluation].
- Author
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Ancelle T, Paugam A, Bourlioux F, Merad A, and Vigier JP
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- Animals, Endemic Diseases, Humans, Male, Mass Screening, Reproducibility of Results, Senegal, Sensitivity and Specificity, Trypanosomiasis, African diagnosis, Centrifugation, Hematocrit, Leukocyte Count, Trypanosoma brucei gambiense, Trypanosomiasis, African blood, Trypanosomiasis, African parasitology
- Abstract
Microhematocrit centrifugation (Woo test) and miniature anion exchange are the most widely used techniques for routine detection of Trypanosoma brucei gambiense in endemic areas. The QBC technique developed for diagnosis of malaria has been successfully used for detection of trypanosoma in blood. The purpose of this laboratory study was to evaluate the end-point sensitivity of the QBC test in comparison with the Woo test. Decreasing concentrations from 15 x 10(5) to 15 trypanosomes/ml of human blood were tested using the two techniques. Sensitivity was calculated in function of reading time at each concentration. Results showed that the sensitivity of the QBC test was 95% down to a concentration of 450 trypanosomes/ml. In comparison 95% sensitivity of the Woo test was observed only down to 7500 trypanosomes/ml and reading time was twofold longer. These findings were reproducible for two hours after sample preparation but deterioration was rapid thereafter. Given its simplicity and sensitivity, QBC test would appear to be a suitable technique for in-field screening programs for human African trypanosomiasis.
- Published
- 1997
75. [The return of trypanosomiasis: a new challenge from a forgotten disease].
- Author
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Ancelle T
- Subjects
- Africa epidemiology, Humans, Trypanosomiasis, African epidemiology, Global Health, Health Priorities, Trypanosomiasis, African prevention & control
- Published
- 1996
76. [Lymphopenia in trichinosis].
- Author
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Dupouy-Camet J, Paugam A, Picard F, and Ancelle T
- Subjects
- CD4-Positive T-Lymphocytes, CD8 Antigens analysis, Humans, Leukocyte Count, Lymphocytes immunology, Lymphopenia etiology, Trichinellosis complications
- Published
- 1994
77. [2 epidemics of arsenical encephalopathy in the treatment of trypanosomiasis, Uganda, 1992-1993].
- Author
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Ancelle T, Barret B, Flachet L, and Moren A
- Subjects
- Adolescent, Adult, Child, Drug Administration Schedule, Drug Interactions, Female, Health Status, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Risk Factors, Seasons, Strongyloidiasis drug therapy, Strongyloidiasis prevention & control, Thiabendazole adverse effects, Thiabendazole therapeutic use, Trypanosomiasis, African prevention & control, Uganda epidemiology, Brain Diseases chemically induced, Brain Diseases epidemiology, Disease Outbreaks, Melarsoprol adverse effects, Trypanocidal Agents adverse effects, Trypanosomiasis, African drug therapy
- Abstract
Since 1988, the french non-governmental organisation Médecins Sans Frontières is running a control program of human african trypanosomiasis in the district of Moyo, North-Uganda. Between 1988 and 1993, more than 7,000 patients were diagnosed and treated. Since 1988, it has been noted that incidence of melarsoprol reaction had increased systematically between June and October of each year, indicating strong seasonal variation. In 1992 and 1993, two outbreaks of arsenical reactive encephalopathy (ARE) occurred in the sleeping sickness center of Adjumani. The incidence of ARE suddenly exceeded 10% of the patients treated by melarsoprol during August 1992 and September 1993. The onset of 80% of those "epidemic" cases, occurred between the 5th and the 11th day of treatment. Two retrospective studies were conducted in 1992 (75 cases) and in 1993 (51 cases). Among the risk factors studied, two appear to increase the risk of ARE: the prescription of thiabendazole to treat strongyloidiasis during the melarsoprol cure and the bad general clinical conditions of patients. These observations suggest that exogenous co-factors could be involved in the occurrence of ARE. Recommendations were to avoid administration of diffusible anti-helminthic treatment during the cure, and to improve the general conditions of patients before the cure of melarsoprol.
- Published
- 1994
78. Neurotrichinosis. A cerebrovascular disease associated with myocardial injury and hypereosinophilia.
- Author
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Fourestie V, Douceron H, Brugieres P, Ancelle T, Lejonc JL, and Gherardi RK
- Subjects
- Aged, Brain Diseases etiology, Brain Diseases pathology, Eosinophilia etiology, Heart Diseases pathology, Humans, Male, Middle Aged, Nervous System Diseases pathology, Trichinellosis etiology, Trichinellosis therapy, Heart Diseases etiology, Nervous System Diseases etiology, Trichinellosis complications
- Abstract
The clinical features, brain computerized tomography (CT) scans and cardiological findings of nine patients with neurotrichinosis are reviewed. Neurological signs consisted of encephalopathy and focal deficits with small hypodensities in the cortex and white matter, detected by the CT scans. Various cardiovascular events were also observed in eight out of nine patients. They were usually concomitant with neurological symptoms and mainly consisted of myocardial injury as assessed by electrocardiographic and plasma creatine phosphokinase (CPK)-MB isoenzyme changes. The cardio-neurological syndrome developed early in the course of the disease at a time of marked hypereosinophilia and the percentage of patients with eosinophilia > or = 4000 mm3 was significantly higher in the patients with neurological dysfunction than in those without neurological signs. We selected the following criteria to describe the distinctive cardio-neurological syndrome related to trichinosis: (i) early onset of neurological symptoms (within a few days) after the first general symptoms; (ii) central nervous system involvement consisting of both diffuse encephalopathy and focal neurological deficits, usually of simultaneous onset; (iii) concomitant acute myocardial injury and/or infarction; (iv) marked hypereosinophilia (> or = 4000/mm3) at time of first cardio-neurological events; (v) brain CT scan showing small hypodensities in the hemispheric white matter or cortex. Post-mortem examination of one patient revealed ischaemic lesions with multiple arteriolar microthrombi in the brain and myocardium. This was consistent with the brain CT scan and electrocardiographic data and suggested that neurotrichinosis is an expression of a multi-organ disorder associated with hypereosinophilia, that is characterized in most patients by simultaneous neurological and myocardial manifestations basically related to ischaemia.
- Published
- 1993
- Full Text
- View/download PDF
79. [Biological and parasitic variations in horses infested and reinfested by Trichinella spiralis].
- Author
-
Soulé C, Dupouy-Camet J, Georges P, Fontaine JJ, Ancelle T, Delvigne A, Perret C, and Collobert C
- Subjects
- Animals, Antibodies, Helminth biosynthesis, Enzyme-Linked Immunosorbent Assay, Female, Fructose-Bisphosphate Aldolase biosynthesis, Granuloma parasitology, Granuloma pathology, Granuloma veterinary, Horse Diseases parasitology, Horse Diseases pathology, Horses, Larva growth & development, Larva immunology, Muscles parasitology, Muscles pathology, Recurrence, Trichinellosis parasitology, Trichinellosis pathology, Trichinellosis physiopathology, Horse Diseases physiopathology, Trichinella spiralis growth & development, Trichinella spiralis immunology, Trichinellosis veterinary
- Abstract
Seven mares were infected with 20,000 Trichinella spiralis larvae; 2 of them were reinfected 22 wk later with the same amount of larvae. The course of infection in horses was assessed by serology (ELISA), biochemistry (aldolase activity), parasitology and histopathology. In each animal, infection was followed by a significant rise in specific antibody titers culminating at 5-10 wk post-infection (pi) and decreasing thereafter. Reinfection was followed by a slight rise in antibody levels. Aldolase activity increased during the first infection, but was not modified by reinfection. The parasite burden was maximum 20 wk pi (24-145 larvae/g according to localisation) and was very low at 52 wk pi (0.4-5 larvae/g). Compared to mares infected only once, the number of parasites in the reinfected animals was similar 28 wk pi but much lower 40 wk pi. Moreover, 6 wk post-reinfection, the larvae were surrounded by a large inflammatory granuloma which could have been caused by larvae from the reinfection batch. These experiments confirm the susceptibility of horses to Trichinella spiralis and the rapid disappearance of specific antibodies which prevents usual serological methods from being used in the diagnosis of infected animals. Reinfection could help the horse to eliminate the larvae more rapidly.
- Published
- 1993
80. [Urban asthma and habitat].
- Author
-
Marzin C, Le Moullec Y, Ancelle T, Juhel J, Festy B, and Pretet S
- Subjects
- Adolescent, Adult, Air Pollution, Indoor adverse effects, Asthma etiology, Child, Child, Preschool, Emergency Medical Services statistics & numerical data, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Paris epidemiology, Prevalence, Residence Characteristics, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Air Pollution, Indoor analysis, Asthma epidemiology, Housing, Urban Health
- Abstract
This study examines in urban area the housing conditions in asthma patients who called a first-aid association of doctors (SOS Médecins) and their relationships to symptoms. The patient population is compared with the non asthmatic population who called SOS Medecins during the same period. During the first six months of 1989, among 102,791 calls, 701 were related to acute asthma symptoms, and 100 non asthma patients were sorted at random as a control group. A telephonic questionnary has been carried out to asthmatic patients and to control group. A particular aspect of asthma in Paris is given in this study: the homogeneous distribution of asthma attacks in the different districts of Paris, (with a light prevalence in three districts of the city). Sex, age, occupation were non discriminant and no significant difference was established in housing conditions and indoor air pollution sources, between the two groups of asthma and non-asthma patients.
- Published
- 1993
81. [Asthma, urban atmospheric pollution and the weather].
- Author
-
Marzin C, Le Moullec Y, Ancelle T, Juhel J, Festy B, and Pretet S
- Subjects
- Acute Disease, Air Pollutants adverse effects, Asthma etiology, Atmospheric Pressure, Databases, Factual, Dyspnea etiology, Emergency Medical Services statistics & numerical data, Humans, Incidence, Ozone adverse effects, Ozone analysis, Paris epidemiology, Seasons, Air Pollutants analysis, Asthma epidemiology, Dyspnea epidemiology, Urban Health, Weather
- Abstract
The aim of this study, which was carried out in an urban environment, was to research in to a possible relationship between temporal variations in the level of atmospheric pollution in the centre of Paris, compared to the frequency of acute dyspnoeic crises in which asthmatic patients had requested the emergency service (SOS Médecins). This study began in the first half of 1989; during this period there were 701 cases of acute asthma recorded within the Paris city boundary by "SOS Médecins". The pollutants recorded were sulphur dioxide (SO2), an index of black smoke (FN), oxides of nitrogen (NOx), ozone (O3) and soluble sulphate particles (SO4). In addition, the weather patterns were examined and pollen counts were recorded. In spite of a sub-acute episode of pollution in January and February, there was no definite increase noted in the number of emergency calls made for acute asthma. In the first three months, the number of crises were, on average, higher in association with high levels of the principal pollutants (SO2 FN, NOx, SO4) as well as with the periods of high atmospheric pressure; however, only the sulphate content and atmospheric pressure remained correlated with the daily number of asthmatic crises. In the second three months, there were some co-variations uniquely associated with sulphate particles, the atmospheric pressure, and above all the ozone level (allowing for a gap of one day). The influence of the daily variations in total pollen content or of grass pollens did not show up in this study.
- Published
- 1993
82. Comparative value of polymerase chain reaction and conventional biological tests for the prenatal diagnosis of congenital toxoplasmosis.
- Author
-
Dupouy-Camet J, Bougnoux ME, Lavareda de Souza S, Thulliez P, Dommergues M, Mandelbrot L, Ancelle T, Tourte-Schaefer C, and Benarous R
- Subjects
- Amniotic Fluid parasitology, Female, Fetal Blood enzymology, Fetal Blood immunology, Humans, Pregnancy, Pregnancy Complications, Parasitic, Toxoplasmosis complications, Toxoplasmosis, Congenital pathology, Polymerase Chain Reaction methods, Prenatal Diagnosis methods, Toxoplasmosis, Congenital diagnosis
- Abstract
When toxoplasmosis is acquired during pregnancy, there is a risk of severe congenital defect in the foetus. Maternal treatment with spiramycin limits the transplacental passage of the parasite to the foetus but does not prevent infection in all cases. Prenatal diagnosis should be based on specific and fast methods to prescribe the more potent combination of sulfadiazine and pyrimethamine. This study evaluates PCR in the prenatal diagnosis of toxoplasmosis; PCR was based on the detection of the gene coding for the P30 surface protein. Amniotic fluid from 44 women with suspected foetal infection was tested by PCR and results were compared to those of conventional diagnostic tests on foetal blood and amniotic fluid. PCR was positive in 7 out of 10 samples from proven congenital toxoplasmosis cases. Sensitivity of PCR was similar to cell culture and mouse inoculation of amniotic fluid but was superior to tests carried out on foetal blood (specific IgM, eosinophil and platelet counts, gamma glutamyl transferase, mouse inoculation). In two cases, PCR was positive with no detected infection of the foetus. In this study, the combination of fast detection methods, ie cell culture and PCR of amniotic fluid, eosinophil and platelet counts, GGT activity and specific IgM, enabled us to confirm 10/10 cases of congenital toxoplasmosis in less than a week. PCR therefore appears to be an additional test which improves early prenatal diagnosis of toxoplasmosis.
- Published
- 1992
83. [News in trichinosis].
- Author
-
Ancelle T
- Subjects
- Animals, Disease Outbreaks, Food Microbiology, France, Horses microbiology, Humans, Trichinellosis microbiology, Trichinellosis transmission, Meat, Trichinella isolation & purification, Trichinellosis epidemiology
- Published
- 1992
84. Detection of repetitive sequences of Trichinella spiralis by the polymerase chain reaction in experimentally infected mice.
- Author
-
Dupouy-Camet J, Soulé C, Guillou JP, Rouer E, Lavareda de Souza S, Ancelle T, and Bénarous R
- Subjects
- Animals, Base Sequence, Blotting, Southern, DNA chemistry, Electrophoresis, Agar Gel, Mice, Molecular Sequence Data, Nucleic Acid Hybridization, Oligonucleotide Probes, Oligonucleotides chemistry, Polymerase Chain Reaction, Trichinellosis parasitology, DNA analysis, Repetitive Sequences, Nucleic Acid, Trichinella genetics, Trichinellosis diagnosis
- Published
- 1991
- Full Text
- View/download PDF
85. [Diagnosis of cerebral toxoplasmosis in AIDS patients. Value of antibodies evaluation in cerebrospinal fluid].
- Author
-
Bougnoux ME, Nicaise P, Heyer F, Ancelle T, Pinquier JL, Dupouy-Camet J, and Tourte-Schaeffer C
- Subjects
- Adult, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Reference Values, Retrospective Studies, Toxoplasmosis cerebrospinal fluid, Toxoplasmosis etiology, Acquired Immunodeficiency Syndrome complications, Immunoglobulin M cerebrospinal fluid, Toxoplasmosis diagnosis
- Abstract
The purpose of this study was to evaluate the diagnostic value of search for intrathecally synthesized specific antibodies in cerebral toxoplasmosis. Intrathecal synthesis of antibodies was measured by calculating the immunity load coefficient (ILC) in both serum and cerebrospinal fluid. In this retrospective study the records of 42 AIDS patients with clinically on the basis of computerized tomography and therapeutic results, and was excluded in 31 patients (control group). Specific immunoglobulins G were found in the cerebrospinal fluid of 9 out of the 11 patients with toxoplasmosis, but also in 14 of the 31 controls. Since ILC measurements in serum and cerebrospinal fluid identified 7/11 cases other hand, since the ILC value was higher than the positivity threshold in controls, the specificity of the test was assessed at 68 percent.
- Published
- 1990
86. [Evaluation of the medical and social cost of 2 trichinosis outbreaks in France in 1985].
- Author
-
Ancelle T, Renaud G, Dupouy-Camet J, and Foulon G
- Subjects
- Adolescent, Adult, Animals, Child, Female, Horses parasitology, Humans, Length of Stay economics, Male, Meat adverse effects, Middle Aged, Paris epidemiology, Trichinellosis epidemiology, Trichinellosis transmission, Disease Outbreaks economics, Trichinellosis economics
- Abstract
Two outbreaks of trichinosis occurred in France in 1985 and 1,073 cases were identified. These outbreaks were related to the consumption of parasitized horse meat. The medical and social cost of these outbreaks have been estimated with a sample of 92 patients. The average medical cost was 1,200 FF by outpatient and 17,300 FF by hospitalized patient. For the 1,073 cases, the total cost of these 2 outbreaks is estimated to have been between 7 and 11 millions FF. Of this sum, the hospitalization fees exceeded 51% and the social cost was 36% (loss of productivity). Since October 1985, a decree of the French Ministry of Agriculture has imposed a parasitologic test on all horse carcasses slaughtered in France or imported. This examination costs under 5 FF (under $1) per carcass. This study shows that the systematic examination for trichinosis of horse meat carcasses should be continued and that more sensitive screening methods should be developed.
- Published
- 1990
87. [The peculiar features of Plasmodium vivax on the Cambodian-Thailand frontier (Sokh-Sann region)].
- Author
-
Lapierre J, Faurant C, Galal A, Coquelin B, Dupouy-Camet J, Tourte-Schaefer C, Ancelle T, and Heyer F
- Subjects
- Cambodia, Humans, Plasmodium vivax cytology, Plasmodium vivax physiology, Thailand, Plasmodium vivax classification
- Abstract
The authors report an untypical strain of Plasmodium vivax found in the area of Sokh-Sann (Thaï-Cambodian border). This strain is remarkable by: multiple infections and two chromatin dots occur commonly in the early trophozoite stage; the pigment is coarser and darker in the older stages, and Schüffner dots are seldom found. The incubation period is longer and the symptomatology more severe.
- Published
- 1983
88. [Hepatic amebiasis. A review of 86 cases seen in Paris].
- Author
-
Lapierre J, Heyer F, Faurant C, Tourte-Schaefer C, and Ancelle T
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Liver Abscess, Amebic drug therapy, Liver Abscess, Amebic epidemiology, Male, Middle Aged, Paris, Serologic Tests, Time Factors, Liver Abscess, Amebic diagnosis
- Published
- 1982
89. [Different immunogenic behaviour of S. mansoni from the Antilles and from western and central Africa].
- Author
-
Lapierre J, Tourte-Schaefer C, Ancelle T, Chochillon C, and Morice J
- Subjects
- Adolescent, Adult, Africa, Central, Africa, Western, Antibodies, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Schistosomiasis epidemiology, Schistosomiasis immunology, Species Specificity, West Indies, Schistosoma mansoni immunology
- Published
- 1979
90. Epidemic visceral leishmaniasis in southern Sudan.
- Author
-
Perea WA, Moren A, Ancelle T, and Sondorp E
- Subjects
- Adolescent, Adult, Animals, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Leishmania donovani immunology, Male, Middle Aged, Retrospective Studies, Sudan epidemiology, Disease Outbreaks, Leishmaniasis, Visceral epidemiology
- Published
- 1989
- Full Text
- View/download PDF
91. [Dirofilariasis in humans. Report of a case with localization in the cheek (author's transl)].
- Author
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Lapierre J, Commissionat Y, Tourte-Schaefer C, Ancelle T, Heyer F, Hassin M, and Faurant C
- Subjects
- Adult, France, Humans, Male, Cheek, Dirofilariasis diagnosis, Skin Diseases, Parasitic diagnosis
- Abstract
Cutaneous dirofilariasis usually affects animals (dogs and cats) but can occur in human-beings. Occasionally, this cosmopolitan disease is seen in France. Our case-report is the sixteenth registered in France. The patient, a forty-two-year-old man, was infected in Corsica. He presented with a tumor of the right cheek from which a pregnant adult Dirofilaria (Nochtiella) repens was extracted.
- Published
- 1982
92. [Recrudescence of imported malaria (author's transl)].
- Author
-
Lapierre J, Holler C, Tourte-Schaefer C, Lebas-Saison E, and Ancelle T
- Subjects
- Africa, France, Humans, Malaria prevention & control, Plasmodium falciparum, Malaria epidemiology
- Abstract
In the light of two recent cases of severe central nervous system malaria due to neglect in chemoprophylaxis, the authors report the very marked recrudescence in imported malaria and draw attention to the frequency of cases due to P. falciparum, the agent of malignant tertian fever and of malignant episodes. The necessity of early diagnosis in such cases is mentioned, together with the treatment of simple malaria and, in particular, of malignant varieties. In order to be effective, chemoprophylaxis must be begun immediately following arrival in an endemic area, continued regularly throughout the stay there and continued for 2 months after leaving. The blood of former malaria suffers, in order to avoid the risks of transfusion malaria, should be used only after seroimmunological studies have demonstrated the absence of anti-malaria antibodies.
- Published
- 1977
93. [Significance of an extended evaluation in urinary bilharziasis].
- Author
-
Lapierre J, Holler C, Tourte-Schaefer C, and Ancelle T
- Subjects
- Cystoscopy, Humans, Schistosomiasis diagnostic imaging, Serologic Tests, Time Factors, Urine parasitology, Urography, Urologic Diseases diagnostic imaging, Urologic Diseases etiology, Schistosomiasis diagnosis, Urologic Diseases diagnosis
- Published
- 1977
94. [Comparison of immune response in patients with bilharziasis (S. mansoni) from Africa south of the Sahara and Antilles].
- Author
-
Cot M, Ancelle T, and Lapierre J
- Subjects
- Adolescent, Adult, Africa, Age Factors, Aged, Antibodies analysis, Child, Child, Preschool, Eosinophilia epidemiology, Humans, Infant, Infant, Newborn, Middle Aged, Retrospective Studies, Schistosoma mansoni immunology, Schistosomiasis mansoni epidemiology, Sex Factors, West Indies, Schistosomiasis mansoni immunology
- Abstract
Retrospective study has been conducted in the parasitic and tropical diseases department of the hospital Cochin, based on observations made between 1966 and 1985 on antibody rates in sera of 709 bilharziasis patients (S. mansoni). This study shows a great difference of immunologic reaction between the group of patients from French West Indies (458 patients) and the one of the group of patients from Africa South of Sahara (189 patients). Such an observation leads the authors to suppose a difference between strains of schistosomes from Black Africa and French West Indies.
- Published
- 1986
95. [Study of specific immunoglobulins (total, IgG, IgM, IgA, IgE) in indirect immunofluorescence and ELISA in 40 patients with trichinosis followed over a 9-month period].
- Author
-
Dupouy-Camet J, Van Knapen F, Ancelle T, Vo Quang D, Lavarde V, and Lapierre J
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Follow-Up Studies, France, Humans, Middle Aged, Time Factors, Trichinellosis epidemiology, Disease Outbreaks, Immunoglobulin A analysis, Immunoglobulin E analysis, Immunoglobulin G analysis, Immunoglobulin M analysis, Trichinellosis immunology
- Abstract
The evolution of the classes of specific immunoglobulins (IgG, IgM, IgA, IgE) of 40 cases of human trichinosis was followed over a nine month period by means of an indirect immunofluorescence test (IF) and ELISA. Specific IgG and IgM appear between 4 and 6 weeks after infection and were still demonstrable after 9 months (respectively in 87.5% and 38.5% of the patients with IF, in 85% and 87.5% with ELISA). Specific IgA were mainly seen on the 2nd month and specific IgE were detected in 37.5% of the patients on the 4th month. In this outbreak, specific antibodies seem to appear later than in a second outbreak observed a few weeks later.
- Published
- 1988
96. [Comparative study of the value of Schistosoma mansoni and Schistosoma haematobium antigens in the indirect immunofluorescent reaction applied to the diagnosis of rectal S. intercalatum bilharziasis].
- Author
-
Lapierre J, Ancelle T, Tourte-Schaefer C, and Roose A
- Subjects
- Adolescent, Adult, Africa, Antigens immunology, Humans, Middle Aged, Schistosoma haematobium immunology, Schistosoma mansoni immunology, Fluorescent Antibody Technique, Rectal Diseases diagnosis, Schistosomiasis diagnosis
- Abstract
A comparative study of the value of antigenic sections of S. mansoni and S. haematobium in indirect immunofluorescence applied to the diagnosis of S. intercalatum rectal bilharziosis (in 66 cases) shows that far better results are obtained with S. haematobium antigen (83,3 0/0 positive reactions with higher titers dilution) than with S. mansoni (33,3 0/0 positive reactions).
- Published
- 1978
97. [A case of porocephalosis disclosed by echography during evaluation of hepatic amebiasis].
- Author
-
Ancelle T, Daireaux P, Chemoul F, and Lapierre J
- Subjects
- Adult, Animals, Arthropods, Humans, Liver Abscess, Amebic diagnosis, Male, Liver Diseases, Parasitic diagnosis, Ultrasonography
- Published
- 1988
98. [Epidemiologic study of 2 foci of Schistosoma mansoni bilharziasis in Togo (Lama Kara and Kpalimé). Comparative efficacy of oltipraz (RP 35972)].
- Author
-
Lapierre J, Amedome A, Tourte-Schaefer C, Agbo K, Kotor T, Faurant C, Ancelle T, Heyer F, and Dupouy-Camet J
- Subjects
- Adolescent, Age Factors, Child, Child, Preschool, Female, Humans, Male, Schistosoma mansoni, Sex Factors, Thiones, Thiophenes, Togo, Nitroquinolines therapeutic use, Oxamniquine therapeutic use, Pyrazines therapeutic use, Schistosomiasis drug therapy, Schistosomiasis epidemiology, Schistosomicides therapeutic use
- Abstract
The authors note a very high prevalence of schistosomiasis mansoni in the two foci studied in Togo (Lama Kara in the North and Kpalimé in the South-West); however, the prevalence is significantly higher in Lama Kara (79.5%) than in Klonou (54.7%); this was calculated on both coprological and serological basis. The parasite burden is identical in the two foci; but, the GMRT is higher in Lama Kara than in Klonou (31.7 and 8) which might be explained by a different immunogenicity of the two strains. It is noticed schistosomiasis mansoni might be responsible for hepatosplenomegaly found in the two foci, especially in Lama Kara, which might be explained by a higher virulence in this location. The treatment by oltipraz (RP 35972) had a 91.9% success rate in Klonou (similar to our results in Paris). However, in Lama Kara, even though the drug was taken with some food--increasing its biodisponibility--, the treatment was less effective at day 180 (76.5%). The authors wonder whether the difference of oltipraz efficiency between the two foci is based on a difference of biology between the two strains of Schistosoma mansoni in Lama Kara and in Klonou.
- Published
- 1984
99. [Immunological diagnosis of echinococcosis. A study of 146 cases, including 8 with bone involvement (author's transl)].
- Author
-
Lapierre J, Morice J, Chochillon C, Ancelle T, and Tourte-Schaefer C
- Subjects
- Antibody Formation, Bone Diseases etiology, Fluorescent Antibody Technique, Humans, Immunity, Cellular, Immunodiffusion, Bone Diseases diagnosis, Echinococcosis diagnosis
- Abstract
After a study about 146 cases of echinococcosis which 8 osseous localizations, indirect immunofluorescence reactions and immunoprecipitation reactions allow for comparing between right immunologic answers in hydatid cyst of liver and hydatid cyst of bone. The right immunogenicity of osseous hydatid cyst can be explained by a close contact host-parasite and by a good vascularization and a good fertility.
- Published
- 1980
100. [Changes in fluorescent antibodies in experimental bilharziasis with S. mansoni and S. haematobium in mice. Comparison of the results obtained using homologous and heterologous antigens].
- Author
-
Lapierre J, Ancelle T, and Roose A
- Subjects
- Animals, Fluorescent Antibody Technique, Mice, Schistosoma haematobium immunology, Schistosoma mansoni immunology, Species Specificity, Time Factors, Antibody Formation, Schistosomiasis immunology
- Abstract
Fluorescent antischistosomiasis antibodies appear earlier in mice infected by 150/200 cercariae than in those who only received 20. The use of a homologous antigen in mice infected by S. mansoni or S. haematobium allows earlier and more important responses. The infections by S. haematobium seem to determinate in mice a more important immune responsiveness. Is it a specific parasitic manifestation (S. mansoni being better adapted to rodents?).
- Published
- 1978
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