51. Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains
- Author
-
Fernando Baquero, Ana Vindel, Sylvia Valdezate, Rafael Cantón, and Elena Loza
- Subjects
Pharmacology ,biology ,Sulfamethoxazole ,Stenotrophomonas maltophilia ,Minocycline ,Microbial Sensitivity Tests ,biology.organism_classification ,Trimethoprim ,Microbiology ,Anti-Bacterial Agents ,Minimum inhibitory concentration ,chemistry.chemical_compound ,Infectious Diseases ,chemistry ,Susceptibility ,Ticarcillin ,medicine ,Humans ,Pharmacology (medical) ,Clinafloxacin ,medicine.drug ,Antibacterial agent - Abstract
Susceptibility to 41 antimicrobials was studied with 99 Stenotrophomonas maltophilia strains, and different pulsed-field gel electrophoresis profiles were identified among 130 prospectively collected isolates. Moxalactam, doxycycline, minocycline, and clinafloxacin displayed the highest activity (≥98% susceptibility). Ticarcillin resistance (75%) was reverted by clavulanate in 25% of strains. Trimethoprim-sulfamethoxazole resistance was 26.2% (≥4 [trimethoprim]/76 [sulfamethoxazole] μg/ml) and dropped to 11.1% when an 8/152-μg/ml breakpoint was applied based on its bimodal MIC distribution. Resistance was lower when unique strains were considered, because clonal organisms contribute to resistance. more...
- Published
- 2001