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65 results on '"Alqahtani, Alaa"'

53. The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae (sensu APGII)

Author

Schwikkard, Sianne, primary, Whitmore, Hannah, additional, Sishtla, Kamakshi, additional, Sulaiman, Rania S., additional, Shetty, Trupti, additional, Basavarajappa, Halesha D., additional, Waller, Catherine, additional, Alqahtani, Alaa, additional, Frankemoelle, Lennart, additional, Chapman, Andy, additional, Crouch, Neil, additional, Wetschnig, Wolfgang, additional, Knirsch, Walter, additional, Andriantiana, Jacky, additional, Mas-Claret, Eduard, additional, Langat, Moses K., additional, Mulholland, Dulcie, additional, and Corson, Timothy W., additional

Published
2019
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62. The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae (sensuAPGII)

Author

Schwikkard, Sianne, Whitmore, Hannah, Sishtla, Kamakshi, Sulaiman, Rania S., Shetty, Trupti, Basavarajappa, Halesha D., Waller, Catherine, Alqahtani, Alaa, Frankemoelle, Lennart, Chapman, Andy, Crouch, Neil, Wetschnig, Wolfgang, Knirsch, Walter, Andriantiana, Jacky, Mas-Claret, Eduard, Langat, Moses K., Mulholland, Dulcie, and Corson, Timothy W.

Abstract

Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangiogenic drugs are strongly needed to supplement existing biologics. Homoisoflavonoids have been previously shown to have potent antiproliferative activities in endothelial cells over other cell types. Moreover, they demonstrated a strong antiangiogenic potential in vitro and in vivo in animal models of ocular neovascularization. Here, we tested the antiangiogenic activity of a group of naturally occurring homoisoflavonoids isolated from the family Hyacinthaceae and related synthetic compounds, chosen for synthesis based on structure–activity relationship observations. Several compounds showed interesting antiproliferative and antiangiogenic activities in vitro on retinal microvascular endothelial cells, a disease-relevant cell type, with the synthetic chromane, 46, showing the best activity (GI50of 2.3 × 10–4μM).

Published
2024
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63. Synthesis and crystal structure of 2-((1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene)-2,3-dihydro-1H-inden-1-one, C23H16N2OS.

Author

Alqahtani, Alaa, Abdel-Wahab, Bakr F., Hegazy, Amany S., Kariuki, Benson M., and El-Hiti, Gamal A.

Subjects
*CRYSTAL structure
Abstract

C23H16N2OS, orthorhombic, Pna21 (no. 33), a = 19.4988(9) Å, b = 19.5060(9) Å, c = 9.2893(4) Å, V = 3533.1(3) Å3, Z = 8, Rgt(F) = 0.0501, wRref(F2) = 0.1269, T = 296(2) K. [ABSTRACT FROM AUTHOR]

Published
2019
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64. Phytochemical Investigations of Three Rhodocodon(Hyacinthaceae Sensu APG II) Species

Author

Schwikkard, Sianne, Alqahtani, Alaa, Knirsch, Walter, Wetschnig, Wolfgang, Jaksevicius, Andrius, Opara, Elizabeth I., Langat, Moses K., Andriantiana, Jackie L., and Mulholland, Dulcie A.

Abstract

The genus Rhodocodon(Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3and 6–8), have been isolated and identified. Compounds 1–3and 6–8have not been described previously. The COX-2 inhibitory activity of compound 6and compound 7acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6and 7Ainhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 μM compared to 12% for 1 mM aspirin (the positive control).

Published
2017
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65. Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations.

Author

Alshaya DS, Al-Hazani TMI, Alotaibi MA, Domiaty DM, Alshehri E, Abdulla Alwaili M, Alotaibi AM, Jalal AS, AlQahtani AA, AlQassim FA, Albasher G, and Saeed Al-Qahtani W

Subjects
Humans, Adolescent, Female, Germ-Line Mutation genetics, Saudi Arabia, Neoplasm Recurrence, Local, Colonic Neoplasms genetics, Breast Neoplasms
Abstract

Various research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon samples, it was analyzed histologically and immunohistochemically with the help of Breast Cancer antibodies (BRCA2 and 1 correspondingly) and H&M staining (hematoxylin and eosin). For this study, 26 at-risk consanguineous cases were considered. Three cases were diagnosed with malignant colon cancer, two with breast cancer, and 17 with germline mutations, yet remain unaffected by cancerous tumors. The rest, four consanguineous cases, are healthy and non-carriers of the mutations. However, as per the exome analysis outcomes, 15 cases inherited germline mutations in nine genes. Nine substitution mutations were present in six of the nine inherited genes in these inherited germline mutations. Furthermore, it also presented six insertion and deletion frameshift mutations in five of nine inherited genes. The immunohistochemical staining process achieved positive staining outcomes for BRCA1 and 2. Therefore, germline mutations inherited from the nine genes of endogamous consanguineous cases of mutation carriers remain the primary reason behind colon cancer recurrence in the same family.

Published
2023
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