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Space-based atmospheric backscatter lidars provide critical information about the vertical distribution of clouds and aerosols, thereby improving our understanding of the climate system. They are additionally useful for detecting hazards to aviation and human health, such as volcanic plumes and man-made pollution events. The Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP, 2006–2023), Cloud-Aerosol Transport System (CATS, 2015–2017), and Advanced Topographic Laser Altimeter System (ATLAS 2018–present) are three such lidars that operated within the past 20 years. The signal-to-noise ratio (SNR) for these lidars is significantly lower in daytime data compared with nighttime data due to the solar background signal increasing the detector response noise. Averaging horizontally across profiles has been the standard way to increase SNR, but this comes at the expense of resolution. Modern, deep learning-based denoising algorithms can be applied to improve the SNR without coarsening resolution. This paper describes how one such model architecture, Dense Dense U-Net (DDUNet), was trained to denoise CATS 1064 nm raw signal data (photon counts) using artificially noised nighttime data. Simulated CATS daytime 1064 nm data were then created to assess the model's performance. The denoised simulated data increased the daytime SNR by a factor of 2.5 (on average) and decreased minimum detectable backscatter (MDB) to ~ 7.3 × 10 − 4 km−1sr−1, which is lower than the CALIOP 1064 nm night MDB value of 8.6 × 10 − 4 km−1sr−1. Layer detection was performed on simulated 2 km horizontal resolution denoised and 60 km averaged data. Despite the finer resolution input, the denoised layers had more true positives, fewer false positives, and an overall Jaccard Index of 0.54 versus 0.44 when compared to the layers detected on averaged data. Layer detection was also performed on a full month of denoised daytime CATS data (Aug. 2015) to detect layers for comparison with CATS standard Level 2 (L2) product layers. The detection on the denoised data yielded 2.33 times more, higher-quality bins within detected layers at 2.7–33 times finer resolution than the CATS L2 products. [ABSTRACT FROM AUTHOR]

Because of the increasing popularity of e-cigarettes, monitoring the e-cigarette market has become important for national health authorities to guarantee safety and quality. In the EU, the Tobacco Products Directive requires emission studies for e-cigarette products. The absence of industry guidelines for studying these emissions and the lack of proper validation in the literature led us to develop and validate a method using the total error approach for the determination of nicotine in e-cigarette aerosols. A commercial vaping device was used to generate aerosols, which were then collected on Cambridge filter pads and measured for nicotine concentration by UHPLC-DAD after extraction. The method was successfully validated by generating accuracy profiles, which show that the β-expectation tolerance intervals remained below the acceptance limits of ±20%. Within-run repeatability and intermediate precision were considered acceptable since the highest RSD value obtained was below 5%. The method was applied to 15 commercial e-liquids. A complete validation of a method for the analysis of e-cigarette emissions is presented, including several parameters that impact the accuracy and reproducibility. Similar systematic approaches for method development and validation could be used for other e-cigarette emission analysis methods to ensure the reliability of the measurements. [ABSTRACT FROM AUTHOR]

This work analyses 10 years (from 2009 to 2018) of long‐range Saharan dust advections (SDAs) and their correlation with the precipitation and radiative budget over the Central Mediterranean region. The identification of the SDAs is based on back‐trajectories (BTs) of air mass and complementary measurements of the dust deposited at the site of Monte Martano in Central Italy. The associated synoptic circulation weather types (CWT), precipitation and radiation variables have been estimated by using ERA5 and CAMS reanalysis, satellite data and raingauge observations. It is found that the 50% of all SDAs occur under a CWT characterized by an upper level trough over the Western Mediterranean and a high‐pressure system over the Eastern Mediterranean. Strong southerly winds, large vertical integral of water vapour transport and a positive anomaly of 2 m temperature are associated with dust uplift and transport. The effect of dust on rainfall intensity puts forward the important modulation of the aerosol effects on the radiative budget with a latitudinal dependence. On dusty days, intense rainfall increases over the northern Central Mediterranean and light rainfall is suppressed in the southern Central Mediterranean, pointing out a relevant correlation between dust and the intensification of extreme events. Other than affecting rainfall intensity, the stronger surface heating over the southern Central Mediterranean, which is correlated to a higher dust optical depth, causes a local maximum of sea surface temperature (SST) and near‐surface temperature anomaly. [ABSTRACT FROM AUTHOR]

The availability of dissolved iron (Fe) limits primary production over some regions of the surface ocean, especially in regions such as the subarctic North Pacific. In this work, we use Fe stable isotope ratios (δ56Fe) in bulk and size-fractionated marine aerosol particles and dissolved Fe of surface seawater in the subarctic North Pacific on Japanese GEOTRACES cruise GP02 (Summer 2017) as a tracer to clarify the relative contribution of combustion and natural Fe in both marine aerosol particles and surface seawater. The bulk aerosols collected in the coastal regions of both East Asia and western North Pacific have total δ56Fe values that are as low as −0.5 ‰ when compared to crustal (+0.1 ‰), with both the water-soluble phase and the fine particles even more fractionated (as low as −1.9 and −2.8 ‰, respectively). The negative correlation between the aerosol δ56Fe signatures and the enrichment factors of Fe and other elements dominated by anthropogenic sources (e.g., lead and cadmium) in these coastal regions indicates the presence of Fe emitted from high-temperature combustion sources, such as coal combustion and metal smelting. In these regions, combustion Fe accounts for 4–13 and 13–45 % of the total and water-soluble aerosol Fe, respectively. The results demonstrate that soluble aerosol Fe sourced from combustion Fe can be equivalent to that sourced from natural dust Fe in these coastal regions. By contrast, the aerosol particles in pelagic regions were near crustal δ56Fe in all particle size fractions, indicating the dominance of natural Fe and little to no combustion Fe. The relationships among the fractional Fe solubility, major ion concentration, Fe species, and δ56Fe indicate that the presence of combustion Fe is the dominant reason for the solubility increase in the coastal regions and that the atmospheric processing of mineral dust during transport is more important in the pelagic regions. The dissolved Fe of the surface seawater at 10 m depth had a consistently higher δ56Fe by up to +1.5 ‰ than that of the simultaneously collected water-soluble aerosol Fe. The pattern of the elevated δ56Fe in the surface seawater corresponds to decreasing Fe concentrations and can be approximated by Rayleigh fractionation; we attribute these elevated surface δ56Fe values to the effect of biological uptake. New Fe fluxes from both the atmosphere and deeper depths are limited at least in summer compared with the biological uptake in the open ocean of the subarctic North Pacific. [ABSTRACT FROM AUTHOR]

This paper discusses the radiation budget and its temporal variability over Poland. The data analysis is based on the MERRA-2 reanalysis for the years 1980–2020. During the last four decades, the enhancement of climate warming has been observed, which coincides with the changes in the radiation budget. Positive and statistically significant trends at the top of the atmosphere (TOA; 0.7 ± 0.2 W/m2/10 year) and on the Earth's surface (1.5 ± 0.2 W/m2/10 year) radiation budget (net downward flux) are mainly a consequence of changes in the amount of aerosol and greenhouse gases (GHG). According to MERRA-2, the AOD during this period decreased by − 0.19 (at 550 nm), which is 87% of the long-term (1980–2021) mean value (0.22). The reduction of AOD is due mainly to the decline of non-absorbing sulfate particles, which leads to a reduction of single-scattering albedo (SSA) by − 0.008 per decade and Angstrom exponent (AE) by − 0.06 per decade (both trends statistically significant). On the other hand, the GHG concentration increased by 4.9%/10 year and 3%/10 year, respectively, for CO2 and CH4. The total column of water vapor increased (1.3%/10 year), while ozone decreased (− 1%/10 year). Despite the fact that cloud cover and cloud optical depth (COD) decreased (− 1.8%/10 year and − 1.0%/10 year), the impact of cloud on temporal variability radiation budget is small. It can be explained by nearly compensated shortwave (SW) cooling and longwave (LW) heating effects. During the analysis period, near-surface air temperature increased by 2.0 °C. The estimated increase in SW net surface radiation (7.9 W/m2) leads to climate warming by 0.8 °C, which is a consequence mainly of the reduction of aerosol (0.4 °C) and cloud cover (0.2 °C). The impact of the change of SW radiation on air temperature is more pronounced during the warm season, while during the cold, air temperature change is controlled mainly by the variability of air mass advection. [ABSTRACT FROM AUTHOR]

Yellow fever (YF), caused by the yellow fever virus (YFV), continually spreads and causes epidemics worldwide, posing a great threat to human health. The live-attenuated YF 17D vaccine (YF-17D) has been licensed for preventing YFV infection and administrated via the intramuscular (i.m.) route. In this study, we sought to determine the immunogenicity and protective efficacy of aerosolized YF-17D via the intratracheal (i.t.) route in mice. YF-17D stocks in liquids were successfully aerosolized into particles of 6 μm. Further in vitro phenotype results showed the aerosolization process did not abolish the infectivity of YF-17D. Meanwhile, a single i.t. immunization with aerosolized YF-17D induced robust humoral and cellular immune responses in A129 mice, which is comparable to that received i.p. immunization. Notably, the aerosolized YF-17D also triggered specific secretory IgA (SIgA) production in bronchoalveolar lavage. Additionally, all immunized animals survived a lethal dose of YFV challenge in mice. In conclusion, our results support further development of aerosolized YF-17D in the future. [ABSTRACT FROM AUTHOR]

A study was conducted to measure aerosol particles emitted from laboratory coats (lab coats) under vibration, comparing them with a suit and a shirt. This study focused on particles ranging from 0.3 μm to >10 μm. Experimental results showed that lab coat vibration increased particles >5 μm while reducing submicron particles. The lab coat (old and used) exhibited greater particle concentration variations under vibration compared to those using the new lab coat or the shirt. Contrastingly, the suit under vibration did not significantly affect particle concentrations. These findings highlight the impact of lab coat vibration on aerosol particle concentrations in the surrounding air, which is important for work environments. [ABSTRACT FROM AUTHOR]

Objectives: N95 or Type II filtering face pieces (FFP2) are often worn during work hours or on public transportation to prevent airborne infection. The aim of this randomized controlled crossover study is to assess the impact of FFP2 induced breathing resistance on pulmonary function, blood gas values and discomfort during walking and stair climbing. Methods: N = 16 healthy adults (24.8 ± 2.2 years; 10 females,) participated. Interventions included (1) six minutes of walking in a 16-meter-long hallway (612 m) and (2) eight minutes of stair climbing in a two-story staircase (420 stairs), both with and without a FFP2 (> 48 h wash-out). Spiroergometric data (Ventilation, breathing frequency, tidal volume, oxygen uptake and carbon dioxide exhalation (primary outcome), end tidal carbon dioxide- and oxygen pressure) and self-reported response (Perceived exertion, dyspnoea and pain) were assessed during activities. Blood gas analysis (capillary carbon dioxide- (pCO2) (primary outcome) and oxygen partial pressure (pO2), pH, lactate and base excess) was measured immediately after cessation of activities. Manipulation effects (FFP2 versus no mask) were tested using repeated measures analyses of variance. Results: Analysis showed no effect of FFP2 on pCO2 or other blood-gas parameters but on carbon dioxide exhalation during walking: (mean 1067, SD 209 ml/min) (mean 1908, SD 426 ml/min) (F(15) = 19.5; p < 0.001; ηp2 = 0.566) compared to no mask wearing (mean 1237, SD 173 ml/min; mean 1908, SD 426 ml/min). Ventilation was decreased and dyspnoea was increased by FFP2 during activities. FFP2 led to lower oxygen uptake and lower end tidal oxygen but higher end tidal carbon dioxide during stair climbing. Conclusions: FFP2 decreased ventilation based on slower breathing patterns and led to limitations in pulmonary gas exchange and increased subjective dyspnoea. However, invasive diagnostics revealed no signs of clinically relevant metabolic effects immediately after everyday physical activities. [ABSTRACT FROM AUTHOR]

This corrigendum addresses an error in the default seawater dimethylsulfide (DMS) climatology used in a study on the influence of coral-reef-derived DMS on the atmosphere of the Great Barrier Reef. The correction states that the correct climatology should be Kettle et al. (1999) instead of Lana et al. (2011). However, this correction does not impact the study's results, and no new seawater DMS measurements for the Great Barrier Reef region have been included in newer climatologies. The document also references three scientific articles that may be relevant to library patrons researching climate and oceanic processes. [Extracted from the article]

Marine dimethylsulfide (DMS) is an important source of natural sulfur to the atmosphere, with potential implications for the Earth's radiative balance. Coral reefs are important regional sources of DMS, yet their contribution is not accounted for in global DMS climatologies or in model simulations. This study accounts for coral-reef-derived DMS and investigates its influence on the atmosphere of the Great Barrier Reef (GBR), Australia, using the Australian Community Climate and Earth System Simulator Atmospheric Model version 2 (ACCESS-AM2). A climatology of seawater surface DMS (DMSw) concentration in the GBR and an estimate of direct coral-to-air DMS flux during coral exposure to air at low tide are incorporated into the model, increasing DMS emissions from the GBR region by 0.02 Tg yr-1. Inclusion of coral-reef-derived DMS increased annual mean atmospheric DMS concentration over northeastern Australia by 29%, contributing to an increase in gas-phase sulfate aerosol precursors of up to 18% over the GBR. The findings suggest that the GBR is an important regional source of atmospheric sulfur, with the potential to influence local-scale aerosol-cloud processes. However, no influence on sulfate aerosol mass or number concentration was detected, even with a reduction in anthropogenic sulfur dioxide emissions, indicating that DMS may not significantly influence the regional atmosphere at monthly, annual or large spatial scales. Further research is needed to improve the representation of coral-reef-derived DMS in climate models and determine its influence on local, sub-daily aerosol-cloud processes, for which observational studies suggest that DMS may play a more important role. [ABSTRACT FROM AUTHOR]

With the ongoing expansion of global observation networks, it is expected that we shall routinely analyze records of geophysical variables such as temperature from multiple collocated instruments. Validating datasets in this situation is not a trivial task because every observing system has its own bias and noise. Triple collocation is a general statistical framework to estimate the error characteristics in three or more observational-based datasets. In a triple colocation analysis, several metrics are routinely reported but traditional multiple-panel plots are not the most effective way to display information. A new formula of error variance is derived for connecting the key terms in the triple collocation theory. A diagram based on this formula is devised to facilitate triple collocation analysis of any data from observations, as illustrated using three aerosol optical depth datasets from the recent Aerosol Cloud meTeorology Interactions oVer the western ATlantic Experiment (ACTIVATE). An observational-based skill score is also derived to evaluate the quality of three datasets by taking into account both error variance and correlation coefficient. Several applications are discussed and sample plotting routines are provided. [ABSTRACT FROM AUTHOR]

Summary: Aerosols could significantly influence ecosystem carbon and water fluxes, potentially altering their interconnected dynamics, typically characterized by water‐use efficiency (WUE). However, our understanding of the underlying ecophysiological mechanisms remains limited due to insufficient field observations.We conducted 4‐yr measurements of leaf photosynthesis and transpiration, as well as 3‐yr measurements of stem growth (SG) and sap flow of poplar trees exposed to natural aerosol fluctuation, to elucidate aerosol's impact on plant WUE.We found that aerosol improved sun leaf WUE mainly because a sharp decline in photosynthetically active radiation (PAR) inhibited its transpiration, while photosynthesis was less affected, as the negative effect induced by declined PAR was offset by the positive effect induced by low leaf vapor pressure deficit (VPDleaf). Conversely, diffuse radiation fertilization (DRF) effect stimulated shade leaf photosynthesis with minimal impact on transpiration, leading to an improved WUE. The responses were further verified by a strong DRF on SG and a decrease in sap flow due to the suppresses in total radiation and VPD.Our field observations indicate that, contrary to the commonly assumed coupling response, carbon uptake and water use exhibited dissimilar reactions to aerosol pollution, ultimately enhancing WUE at the leaf and canopy level. [ABSTRACT FROM AUTHOR]

The focus on aerosol analysis in the Levantine Region is driven by climate-change impacts, the region's increasing urban development and industrial activities, and its geographical proximity to major dust-source areas. This study conducts a comparative analysis of aerosol optical depth data from Aqua/MODIS and AERONET during different periods between 2003 and 2023 at four stations: IMS-METU-ERDEMLI (Mersin/Türkiye) (2004–2019), CUT-TEPAK (Limassol/Cyprus) (2010–2023), Cairo_EMA_2 (Cairo/Egypt) (2010–2023), and SEDE_BOKER (Sede Boker/Israel) (2003–2023). The objective is to evaluate the variability and reliability of AOD measurements between satellite and ground-based observations and to determine how well they represent regional climatology. The highest percentage of measurements within the expected error envelope was observed at the IMS-METU-ERDEMLI station, indicating the best agreement between MODIS and AERONET data at this location. The Seasonal-Trend Decomposition using Loess (STL) method revealed consistent spring and summer peaks influenced by dust transport from the Sahara and the Middle East, with lower values in winter. The study also considers the influence of cloud fraction on MODIS measurements and includes aerosol classification. A statistically significant slight positive trend in AOD values was identified at the IMS-METU-ERDEMLI station. Conversely, no significant trends were detected at the other stations. The results of this study agree with those of previous research on the impact of long-range dust transport on regional aerosol loadings, emphasizing the importance of integrating satellite and ground-based observations. [ABSTRACT FROM AUTHOR]

Weekly cycles (WCs) in cloud properties have been reported and linked to aerosol effects. Yet the extent to which human activities contribute to their occurrence remains unclear. Here, we revisit aerosol–cloud interactions from the WCs over central Europe using long‐term satellite and reanalysis data. Significant WCs in aerosol and cloud droplet number concentration (Nd) are detected with minima/maxima on Monday/Friday, indicating a clear signal of the Twomey effect. Notably, Nd–to–aerosol sensitivity from WCs is found to decrease at larger aerosol concentrations, confirming the nonlinear behavior of the aerosol–Nd relation (in log–log space) reported previously, but from a distinct perspective. Nevertheless, no discernible WCs in liquid water path are found. The pronounced WCs in cloud cover are demonstrated to be driven by natural variability. Our results indicate that the WCs offer a useful pathway for investigating the Twomey effect, but are not as effective for detecting cloud adjustments. Plain Language Summary: Aerosol–cloud interactions are the largest uncertainty in the anthropogenic forcing of climate. Specifically, an increase in aerosols increases cloud droplet number concentration (the Twomey effect), which further changes liquid water path and cloud cover (cloud adjustments), ultimately alters radiations. Weekly cycles would be a useful tool for such study, assuming no 7‐day periodicity in meteorological dynamics. In this study, we revisit aerosol–cloud interactions from weekly cycles using long‐term satellite observations and reanalysis data. The analysis is restricted to central Europe—a region with strong weekly cycles in anthropogenic emissions. We find significant weekly cycles in aerosol and cloud droplet number concentration with minima/maxima on Monday/Friday. Importantly, the sensitivity of cloud droplet number concentration to aerosol is found to decrease in polluted conditions, confirming the behavior of the nonlinear cloud response to aerosol as reported previously. It is demonstrated that the weekly cycle in liquid water path is negligible; though a pronounced cycle in cloud cover detected, it is predominately caused by natural variability. Hence, caution is warranted when attributing observed weekly cycle in cloud cover to aerosol effects. Conclusively, weekly cycles are useful for detecting the Twomey effect but less effective for cloud adjustments. Key Points: The analysis of weekly cycles reveals a reduced sensitivity of cloud droplet number concentration to aerosol at larger aerosol loadingThe strong weekly cycle in cloud cover is mainly a result of natural variability rather than being attributed to aerosol effectsWeekly cycles offer a useful pathway to investigating the Twomey effect, but are not as effective for detecting cloud adjustments [ABSTRACT FROM AUTHOR]

Background: Zinc fever is well described in medical literature, particularly in workers after handling zinc-containing materials at high temperatures e.g., in the welding of hot-dip galvanized steel sheets. It is not known whether zinc fever also occurs at low temperatures. Case presentation: We present the case of a 33-year-old Caucasian atopic painter and varnisher with work-related dyspnea, sweating, as well as multiple occurrences of fever. He was sent to Institute for Prevention and Occupational medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA) for the evaluation of isocyanate asthma, but an inhalative challenge with hexamethylene diisocyanate was negative. Since symptoms were closely related to the use of zinc coatings at room temperature without adequate protective measures, the diagnosis of zinc fever was made. After exposure cessation the worker immediately became symptom-free. The work as painter and varnisher may be associated with various exposures to hazardous substances. Besides solvents, epoxy compounds and isocyanates, which can cause obstructive respiratory diseases; additionally, zinc-containing agents should be considered as health hazards. Conclusions: This case demonstrates that zinc fever may occur also after application of zinc coatings by spray painting at low temperatures. [ABSTRACT FROM AUTHOR]

Enclosed public spaces are hotspots for airborne disease transmission. To measure and maintain indoor air quality in terms of airborne transmission, an open source, low cost and distributed array of particulate matter sensors was developed and named Dynamic Aerosol Transport for Indoor Ventilation, or DATIV, system. This system can use multiple particulate matter sensors (PMSs) simultaneously and can be remotely controlled using a Raspberry Pi-based operating system. The data acquisition system can be easily operated using the GUI within any common browser installed on a remote device such as a PC or smartphone with a corresponding IP address. The software architecture and validation measurements are presented together with possible future developments. [ABSTRACT FROM AUTHOR]

The exacerbation of air pollution during spring in Yunnan province, China, has attracted widespread attention. However, many studies have focused solely on the impacts of anthropogenic emissions while ignoring the role of natural processes. This study used satellite data spanning 21 years from the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Atmospheric Infrared Sounder (AIRS) to reveal two natural processes closely related to springtime ozone (O3) and PM2.5 pollution: stratospheric intrusions (SIs) and cross-border transport of biomass burning (BB). We aimed to assess the mechanisms through which SIs and cross-border BB transport influence O3 and PM2.5 pollution in Southwestern China during the spring. The unique geographical conditions and prevalent southwest winds are considered the key driving factors for SIs and cross-border BB transport. Frequent tropopause folding provides favorable dynamic conditions for SIs in the upper troposphere. In the lower troposphere, the distribution patterns of O3 and stratospheric O3 tracer (O3S) are similar to the terrain, indicating that O3 is more likely to reach the surface with increasing altitude. Using stratospheric tracer tagging methods, we quantified the contributions of SIs to surface O3, ranging from 6 to 31 ppbv and accounting for 10–38% of surface O3 levels. Additionally, as Yunnan is located downwind of Myanmar and has complex terrain, it provides favorable conditions for PM2.5 and O3 generation from cross-border BB transport. The decreasing terrain distribution from north to south in Yunnan facilitates PM2.5 transport to lower-elevation border cities, whereas higher-elevation cities hinder PM2.5 transport, leading to spatial heterogeneity in PM2.5. This study provides scientific support for elucidating the two key processes governing springtime PM2.5 and O3 pollution in Yunnan, SIs and cross-border BB transport, and can assist policymakers in formulating optimal emission reduction strategies. [ABSTRACT FROM AUTHOR]

Sea fog is a societally relevant phenomenon that occurs under the influence of specific oceanic and atmospheric conditions including aerosol conditions. The Yellow Sea region in China regularly experiences sea fog events, of varying intensity, that impact coastal regions and maritime activities. The occurrence and structure of fog are impacted by the concentration of aerosols in the air where the fog forms. Along with industrial development, air pollution has become a serious environmental problem in Northeastern China. These higher pollution levels are confirmed by various satellite remote sensing instruments including the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Aqua satellite that observes aerosol and cloud properties. These observations show a clear influence of aerosol loading over the Yellow Sea region, which can impact regional sea fog. In this study, high-resolution data sets from MODIS Aqua L2 are used to investigate the relationships between cloud properties and aerosol features. Using a bi-variate comparison method, we find that, for most cases, larger values of COT (cloud optical thickness) are related to both a smaller DER (droplet effective radius) and higher CTH (cloud top height). However, in the cases where fog is thinner with many zero values in CTH, the larger COT is related to both a smaller DER and CTH. For fog cases where the aerosol type is dominated by smoke (e.g., confirmed fire activities in the East China Plain), the semi-direct effect is indicated and may play a role in determining fog structure such that a smaller DER corresponds with thinner fog and smaller COT values. [ABSTRACT FROM AUTHOR]

The East Asian winter monsoon (EAWM) is an important climate pattern in Southeast Asia. This study delved into the aerosol effects on the EAWM by analysing simulations conducted with the Taiwan Earth System Model version 1 (TaiESM1) model, part of the Coupled Model Intercomparison Project Phase 6 (CMIP6). Our assessment, validated against observational and reanalysis data, revealed that TaiESM1 effectively replicates the robust circulation of the EAWM and aerosol concentrations, placing its performance above average level among CMIP6 models. Notably, the simulated global mean aerosol optical thickness exhibited an approximately 20% increase from 1850 to 2014. The increased aerosols corresponded to a weakened Aleutian Low and an intensified Siberian High, leading to a weakened EAWM in the lower atmosphere over extratropical areas. In addition, the cooling across the Northern Hemisphere might affect enhanced northerly winds at approximately 10°N, which are situated in the southern part of the EAWM. An analysis of the near‐surface temperature budget indicated that the aerosol‐induced cooling in East China and India was primarily driven by changes in shortwave and longwave radiation fluxes, albeit slightly offset by sensible heat and latent heat fluxes. Furthermore, our study also reveals that while the mechanisms through which anthropogenic aerosols affect the northern portion of the EAWM vary across most CMIP6 models, their impacts on the tropical region remain consistent. [ABSTRACT FROM AUTHOR]

Laser-induced fluorescence spectroscopy (LIFS) is actively used for remote sensing of atmospheric aerosols and is currently one of the most sensitive and selective techniques for determining small concentrations of substances inside particles. The use of high-power femtosecond laser sources for LIFS-based remote sensing of aerosols contributes to the development of new-generation fluorescence atmospheric lidars since it makes it possible to overcome the energy threshold for the nonlinear-optical effects of multiphoton absorption in particles and receive the emission signal at long distances in the atmosphere. Our study is aimed at the development and experimental demonstration of the technique of nonlinear laser-induced fluorescence spectroscopy (NLIFS) based on the remote excitation of aerosol fluorescent emission stimulated by a spatially structured high-power femtosecond laser pulse. Importantly, for the first time to our knowledge, we demonstrate the advances in using stochastically structured plasma-free intense light channels (postfilaments) specially formed by the propagation of femtosecond laser radiation through a turbulent air layer to improve NLIFS efficiency. A multiple increase in the received signal of two-photon-excited fluorescence of polydisperse-dyed aqueous aerosols by the structured postfilaments is reported. [ABSTRACT FROM AUTHOR]

Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorganisms that populate the respiratory tract. The impact of microbial communities and inter-pathogen interactions upon stability of transmitted viruses is well-characterized for enteric pathogens, but is under-studied in the respiratory niche. Here, we assessed whether the presence of five different species of commensal respiratory bacteria could influence the persistence of IAV within phosphate-buffered saline and artificial saliva droplets deposited on surfaces at typical indoor air humidity, and within airborne aerosol particles. In droplets, presence of individual species or a mixed bacterial community resulted in 10- to 100-fold more infectious IAV remaining after 1 h, due to bacterial-mediated flattening of drying droplets and early efflorescence. Even when no efflorescence occurred at high humidity or the bacteria-induced changes in droplet morphology were abolished by aerosolization instead of deposition on a well plate, the bacteria remained protective. Staphylococcus aureus and Streptococcus pneumoniae were the most stabilizing compared to other commensals at equivalent density, indicating the composition of an individual’s respiratory microbiota is a previously unconsidered factor influencing expelled virus persistence. IMPORTANCE It is known that respiratory infections such as coronavirus disease 2019 and influenza are transmitted by release of virus-containing aerosols and larger droplets by an infected host. The survival time of viruses expelled into the environment can vary depending on temperature, room air humidity, UV exposure, air composition, and suspending fluid. However, few studies consider the fact that respiratory viruses are not alone in the respiratory tract—we are constantly colonized by a plethora of bacteria in our noses, mouth, and lower respiratory system. In the gut, enteric viruses are known to be stabilized against inactivation and environmental decay by gut bacteria. Despite the presence of a similarly complex bacterial microbiota in the respiratory tract, few studies have investigated whether viral stabilization could occur in this niche. Here, we address this question by investigating influenza A virus stabilization by a range of commensal bacteria in systems representing respiratory aerosols and droplets. [ABSTRACT FROM AUTHOR]

BACKGROUND: Optimal aerosol delivery methods for spontaneously breathing patients with a tracheostomy remain unclear. Thus, we aimed to assess the impact of nebulizer placement, flow settings, and interfaces on aerosol delivery by using a vibrating mesh nebulizer and a jet nebulizer in line with unheated humidification. METHODS: An 8.0-mm tracheostomy tube was connected to the lung model that simulates adult breathing parameters via a collecting filter. Albuterol sulfate (2.5 mg/3 mL) was administered via a vibrating mesh nebulizer and a jet nebulizer, which was placed in line with unheated humidification provided by a large-volume nebulizer, with FIO2 set at 0.28, with gas flows of 2 L/min versus 6 L/min. Nebulizers were placed in line distal and proximal to the lung model by using a tracheostomy collar and a T-piece. Conventional nebulization was tested using a vibrating mesh nebulizer and a jet nebulizer directly connected to the tracheostomy tube bypassing the humidification device. The drug was eluted from the collecting filter and assayed with ultraviolet spectrophotometry (276 nm). RESULTS: During in-line nebulizer placement with unheated humidification, the inhaled dose was 2-4 times higher with a gas flow of 2 L/min than 6 L/min, regardless of nebulizer type, placement, or interface (all P < .05). At 6 L/min, the inhaled dose was higher with proximal than distal placement when using both interfaces, but, at 2 L/min, the inhaled dose was lower with proximal placement. With a jet nebulizer, the tracheostomy collar generated a higher inhaled dose at proximal placement compared with the T-piece, whereas the T-piece resulted in a higher inhaled dose than the tracheostomy collar with distal placement, regardless of the flow settings. Compared with conventional nebulization using a vibrating mesh nebulizer, an in-line vibrating mesh nebulizer with a large-volume nebulizer at 2 L/min had a similar inhaled dose, regardless of nebulizer placement and interface. In contrast, the in-line jet nebulizer was influenced by both placement and interface. CONCLUSIONS: Aerosol delivery with an in-line vibrating mesh nebulizer and jet nebulizer with unheated humidification was affected by nebulizer placement, interface, and gas flow settings. [ABSTRACT FROM AUTHOR]

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Dust is a common meteorological phenomenon in arid and semi-arid regions of the world, which is caused by natural or human factors. The frequency and intensity of dust have increased in the last two decades. Identifying the active sources of dust is the first step in dealing with it and reducing its harmful consequences. For this purpose, two indices of aerosol optical depth (AOD) and the normalized difference vegetation index (NDVI) from the moderate resolution imaging spectroradiometer (MODIS) sensor of the Terra satellite have been used for the last two decades (2001-2021). To investigate dust events in the study area, the frequency of occurrence of aerosol optical depth (FoO) was investigated with three thresholds of 0.3, 0.5, and 1. The maximum AOD values are related to the spring and summer seasons. Regions with an aerosol optical depth of more than 1 are only limited to the warm period of the year and the areas of Mesopotamia region, Arabian deserts, desert areas of Syria, Dasht-e Margo and Dasht-e Sistan, and eastern Pakistan. The nationwide dust that covers wide areas in Saudi Arabia and the Persian Gulf countries and the west and southwest of Iran are mostly more than 0.5 in terms of AOD values. In general, six hotspots of dust can be identified based on the values of the AOD and FoO index for the West Asian region. These six regions are 1- Thar desert in Pakistan, 2- Rub' al Khali, Ad-Dahna, Al Nufud Al Kabirdesert in Saudi Arabia, 3- the Syrian desert, 4- the Desert regions of Iraq and especially the Mesopotamia region, 5- Dry and desert regions of Oman, 6- Dasht-e Margo and Dasht-e Sistan (in Afghanistan and Iran). These dust hotspots are found in arid, desert, and hot climate regions (BWh). The only effective hotspots in northeastern Iran are located in the arid, desert, and cold climate region (BWk) in Turkmenistan. In general, dust hotspots have an inverse relationship with vegetation, although this relationship is more for spring hotspots. Regardless of the determining role of surface characteristics in the occurrence of dust, two meteorological phenomena, the summer Shamal wind and the wind of 120 days of Sistan, have a determining role in the formation of hotspots with higher AOD values of 0.5 and 1. The area-averaged time series of MOD04 product values show that the value of AOD is increasing. Also, the results showed that the increase in AOD values from the 2010s onwards shows an upward trend compared to that of the 2000s. The dry bed of lakes and alluvial sources (Mesopotamia), human activities on the one hand, and the occurrence of drought and climate change, on the other hand, are directly related to the extent and intensity of dust events in West Asia. [ABSTRACT FROM AUTHOR]

Aerosol increases over the 20th century delayed the rate at which Earth warmed as a result of increases in greenhouse gases (GHGs). Aggressive aerosol mitigation policies arrested aerosol radiative forcing from ∼1980 to ∼2010. Recent evidence supports decreases in forcing magnitude since then. Using the approximate partial radiative perturbation (APRP) method, future shortwave aerosol effective radiative forcing changes are isolated from other shortwave changes in an 18‐member ensemble of ScenarioMIP projections from phase 6 of the Coupled Model Intercomparison Project (CMIP6). APRP‐derived near‐term (2020–2050) aerosol forcing trends are correlated with published model emulation values but are 30%–50% weaker. Differences are likely explained by location shifts of aerosol‐impacting emissions and their resultant influences on susceptible clouds. Despite weaker changes, implementation of aggressive aerosol cleanup policies will have a major impact on global warming rates over 2020–2050. APRP‐derived aerosol radiative forcings are used together with a forcing and impulse response model to estimate global temperature trends. Strong mitigation of GHGs, as in SSP1‐2.6, likely prevents warming exceeding 2C since preindustrial but the strong aerosol cleanup in this scenario increases the probability of exceeding 2C by 2050 from near zero without aerosol changes to 6% with cleanup. When the same aerosol forcing is applied to a more likely GHG forcing scenario (i.e., SSP2‐4.5), aggressive aerosol cleanup more than doubles the probability of reaching 2C by 2050 from 30% to 80%. It is thus critical to quantify and simulate the impacts of changes in aerosol radiative forcing over the next few decades. Plain Language Summary: Over the 20th century, fossil fuel burning led to increased concentrations of greenhouse gases (GHGs) and small particles known as aerosols. Aerosols scatter sunlight back to space and enhance cloud brightness and longevity, thus cooling Earth. The amount of warming since the pre‐industrial depends upon both GHGs and aerosol. After ∼1980, air quality improvements led to a reduction in this cooling effect, unmasking some of the GHG potential to warm the planet. This has reinforced the importance of understanding the interplay between aerosols and GHGs in climate projections. To examine this sensitivity, we use a set of global climate model simulations forced by a variety of future GHG and aerosol concentration based on plausible socioeconomic pathways. Shifts in the location of regional aerosol emissions has an impact on the global climate, influencing the accuracy of our predictions for Earth's future warming as measured by the probability of increasing global temperatures by 2C by 2050 compared to pre‐industrial. Under plausible GHG scenarios, aggressive aerosol cleanup policies can more than double the probability of crossing this threshold. This emphasizes the urgency of improving our simulations in order to accurately predict and quantify the impact of aerosols over the next few decades. Key Points: Aerosol forcing changes are isolated from CMIP6 projected scenarios using an approximate partial radiative perturbation methodAerosol‐cloud interactions dominate future aerosol forcing changes from cleanup policies over the period 2020–2050Likelihood of maintaining global warming to below 2C will be strongly reduced by implementing aggressive near‐term aerosol cleanup policies [ABSTRACT FROM AUTHOR]

Aerosol optical depth (AOD) is a vital parameter in atmospheric research. Using observations of the Visible Infrared Imaging Radiometer Suite (VIIRS), onboard Suomi National Polar‐orbiting Partnership (Suomi‐NPP) and NOAA‐20 satellites, National Oceanic and Atmospheric Administration (NOAA) produces near‐real time AOD product with high pixel resolution (750 m), wide swath width (3,040 km), and a 16‐day repeat cycle. Here we report the evaluation of the NOAA/VIIRS AOD using a comprehensive aerosol data set, derived from a global‐scale, multi‐seasonal airborne mission, the NASA Atmospheric Tomography Mission (ATom). This data set includes rich physical and chemical information, such as size distributions, chemical compositions, optical properties, and hygroscopicities of major aerosol types, including dust, sea salt, smoke, internally mixed sulfate/nitrate/organics particles (non‐smoke), black carbon, etc. Globally, VIIRS AOD (Suomi‐NPP and NOAA‐20) shows good agreement with the ATom AOD in the moderate to high AOD range (>0.3), with respect to measurement uncertainties (orthogonal distance regression fitting slope: 1.5 ± 0.2 for Suomi‐NPP and 1.6 ± 0.5 for NOAA‐20; correlation coefficient: 0.85 for Suomi‐NPP and 0.73 for NOAA‐20). There is a persistent bias in the low AOD range (<0.3) on the order of 0.03, likely reflecting systematic errors on VIIRS and/or the ATom AOD product. Ångström exponent reported by VIIRS shows excellent agreement with ATom results within expected uncertainties. Given the unique insights revealed by the ATom AOD and aerosol property data set, it is desirable to have ATom‐like comprehensive payloads in future airborne satellite validation programs. Plain Language Summary: Aerosol optical depth (AOD) plays a crucial role in air quality and climate. Satellites have been used to retrieve AOD and other aerosol properties for decades; but satellite retrievals are indirect measurements and need validation using direct measurements. Visible Infrared Imaging Radiometer Suite (VIIRS) is the state‐of‐the‐art instrument that retrieves AOD along with other aerosol properties. In this work, we use the comprehensive aerosol data set from the recent global‐scale, multi‐seasonal ATom field campaign, to evaluate the operational VIIRS AOD product on two satellites (NOAA‐20 and SNPP). This data set includes rich physical and chemical information, such as size distributions, chemical compositions, optical properties, and hygroscopicities of major aerosol types, including dust, sea salt, smoke, internally mixed sulfate/nitrate/organics particles, black carbon, etc. Our analysis shows that the operational VIIRS AOD product is generally accurate and robust. A small bias in the low AOD range has been identified, which could be partially explained by the atmospheric variability, but likely reflects systematic errors on VIIRS and/or the ATom AOD product. Our effort further justifies the global scale suborbital airborne missions (such as HIPPO and ATom) and its unique role in atmospheric/climate research as well as operations. Key Points: National Oceanic and Atmospheric Administration (NOAA)/Visible Infrared Imaging Radiometer Suite (VIIRS) Aerosol optical depth (AOD) (Suomi National Polar‐orbiting Partnership [Suomi‐NPP] and NOAA‐20) generally shows good agreement with the AOD product derived from global‐scale airborne observationsThere is a persistent bias in the low AOD range (<0.3), likely reflecting systematic errors on VIIRS and/or the ATom AOD productComprehensive aerosol observations offer invaluable information for satellite validation and model evaluation [ABSTRACT FROM AUTHOR]

The cloud properties and governing processes in Southern Ocean marine boundary layer clouds have emerged as a central issue in understanding the Earth's climate sensitivity. While our understanding of Southern Ocean cloud feedbacks have evolved in the most recent climate model intercomparison, the background properties of simulated summertime clouds in the Southern Ocean are not consistent with measurements due to known biases in simulating cloud condensation nuclei concentrations. This paper presents several case studies collected during the Capricorn 2 and Marcus campaigns held aboard Australian research vessels in the Austral Summer of 2018. Combining the surface‐observed cases with MODIS data along forward and backward air mass trajectories, we demonstrate the evolution of cloud properties with time. These cases are consistent with multi‐year statistics showing that long trajectories of air masses over the Antarctic ice sheet are critical to creating high droplet number clouds in the high latitude summer Southern Ocean. We speculate that secondary aerosol production via the oxidation of biogenically derived aerosol precursor gasses over the high actinic flux region of the high latitude ice sheets is fundamental to maintaining relatively high droplet numbers in Southern Ocean clouds during Summer. Plain Language Summary: The amount of warming the Earth will experience because of increasing carbon dioxide levels in the atmosphere is sensitive to the properties of clouds that occur over the Southern Ocean. The atmosphere over the circumpolar Southern Ocean is poorly understood and presents significant challenges to climate models. Here we document the properties of the ubiquitous Southern Ocean low‐level clouds that exert a strong influence on the albedo of this region. We find that high cloud droplet number concentrations are associated with air masses that have taken paths over the high‐altitude ice sheets. The chemistry of the aerosol on which the cloud droplets form suggests that aerosols that have recently condensed from gasses emitted by phytoplankton in the highly productive waters near Antarctica are an important component of the cloud properties that must be correctly simulated in models. Key Points: High cloud droplet number concentrations are associated with air masses that have recently passed over continental AntarcticaCloud droplet number concentrations decrease with time as clouds evolve in over‐water trajectories due to scavenging by precipitationKatabatic flows bring high concentrations of cloud condensation nuclei to the marine boundary layer where they influence cloud properties [ABSTRACT FROM AUTHOR]

Current models estimate global aviation contributes approximately 5% to the total anthropogenic climate forcing, with aerosol‐cloud interactions having the greatest effect. However, radiative forcing estimates from aviation aerosol‐cloud interactions remain undetermined. There is an expected significant increase in aircraft emissions with aviation demand expected to rise by over 4% per year. Soot may play an important role in the ice nucleation of aircraft‐induced cirrus formation due to a high emission rate, but the ice nucleating properties are poorly constrained. Understanding the microphysical processes leading to atmospheric ice crystal formation is crucial for the reliable parameterization of aerosol‐cloud interactions in climate models due to their impact on precipitation and cloud radiative properties. Ice nucleation of aircraft‐emitted soot is potentially affected by particle morphology with condensation of supercooled water occurring in pores followed by ice nucleation. However, soot has heterogeneous properties and undergoes atmospheric aging and oxidation that could change surface properties and contribute to complex ice nucleation processes. This review synthesizes current knowledge of ice nucleation catalyzed by aviation in the cirrus regime and its effects on global radiative forcing. Further research is required to determine the ice nucleation and microphysical processes of cirrus cloud formation from aviation emissions in both controlled laboratory and field investigations to inform models for more accurate climate predictions and to provide efficient mitigation strategies. Plain Language Summary: Aerosol particles can facilitate ice crystal formation in clouds that affect Earth's precipitation and climate by altering the amount of sunlight that clouds reflect and is absorbed by Earth. Human‐induced pollution may affect atmospheric ice nucleation, such as black carbon (soot) from aircraft emissions. It has been known for decades that carbon dioxide is a major greenhouse gas emitted from aircraft that significantly warms Earth's surface, but the climate effects of aerosol‐cloud interactions are still largely unknown. An understanding of what aerosol particles in the atmosphere contribute to ice nucleation is needed to better predict how they will affect future climate. This review summarizes what we currently know about ice nucleation processes from aircraft soot emissions and identifies future research priorities to understand human‐induced ice cloud formation to better predict how it may affect global climate. Key Points: Ice nucleation is a current major uncertainty in predicting future climate from aerosol‐cloud interactionsThis review synthesizes the current state of knowledge on ice nucleation from anthropogenic aircraft emissionsFuture research includes direct observations and laboratory measurements of ice nucleation microphysical processes from aircraft emissions [ABSTRACT FROM AUTHOR]

In order to investigate the variations of cloud and aerosol vertical profiles over the Tibetan Plateau (TP) in winter, we performed ground-based lidar observations in Lhasa, a city on the TP, from November 2021 to January 2022. The profiles of extinction coefficient, depolarization ratio, and signal-to-noise ratio (SNR) were retrieved using the atmospheric echo signals collected by the lidar. Clouds were identified by the range-correction echo signals and classified into water clouds, mixed clouds, horizontally oriented ice crystal clouds (HOICC), and ice clouds by the depolarization ratio and the hourly temperature from the European Centre for Medium-Range Weather Forecasts Reanalysis version 5 (ERA5). The clouds mainly appeared at a height of 3~5 km from 14:00–22:00 Beijing Time throughout the field campaign. The height and frequency (~30%) for cloud appearance were significantly lower than that reported in previous studies in summer. The cloud categories were dominated by mixed clouds and ice clouds during the observation period. The proportions of ice clouds gradually increased with increasing heights. After eliminating profiles influenced by clouds, the aerosol extinction coefficient and depolarization ratio were obtained, and the atmospheric boundary layer height (ABLH) was calculated. The aerosol extinction coefficient decreased with increasing height in the ABLH, and there were no obvious changes for the aerosol extinction coefficient above the ABL. The aerosol extinction coefficients near the Earth's surface presented two peaks, appearing in the morning and evening, respectively. The high aerosols at the surface in the morning continually spread upward for 4–5 h and finally reached an altitude of 1 km with the development of ABLH. In addition, the depolarization ratio of aerosols decreased slowly with increasing altitudes. There was no obvious diurnal variation for depolarization ratios, indicating partly that the source of aerosols did not change significantly. These results are beneficial in understanding the evolution of cloud and aerosol vertical profiles over the TP. [ABSTRACT FROM AUTHOR]

Introduction: Dental procedures, including ultrasonic scaling, can generate aerosols and droplets, contaminating the dental room and spreading infectious pathogens. To prevent infection, dental associations recommend pre-procedural mouthwash. Various mouthwashes, such as povidone-iodine, chlorhexidine, aloe vera extract and mouthwash with essential oil, are available, but scientific evidence is needed to evaluate the efficacy of their use as preprocedural mouthrinse. Objective: To assess the effectiveness of four commercially available mouth rinses as preprocedural rinses in reducing the number of viable bacteria in dental aerosol generated during ultrasonic scaling. Materials and methods: Twenty eight participants were chosen at random to rinse with any of the mouthwashes for 30 seconds. The mouthwashes used in this study are Betadine®, Minosep®, Listerine® and Aloclair® No dilution of mouthwash was performed throughout this study. The mouthwash is commercially available with a ready-to-use solution. While doing ultrasonic scaling, agar medium plates were placed on the patient's, dentist's, and dental assistant's chests. The plate is then incubated to count how many colonies have formed. The data collected were analyzed using two-factor ANOVA without repeated measures. Results: The mouthwash does not have any impact on the variable reduction CFU in Patient-Dentist-Dental Assistant. However, the data clearly indicates that all mouthwashes effectively decrease the amount of colonies. Conclusion: The reduction in CFU after rinse with those mouthwash highlights the significance of preprocedural mouthwash in lowering oral bacteria numbers prior to minimizing bacteria in dental aerosol formation. Therefore, pre-procedural mouthrinsemay be considered beneficial. [ABSTRACT FROM AUTHOR]

The worldwide spread of COVID-19 viruses induced many people to pay attention to indoor air quality. In this study, multiple air cleaners were installed in a four-bed ward equipped with a ventilation system to enhance indoor air quality by finding optimal air cleaner operation combinations. The age of air was used as an index to assess indoor air quality. The age of air distribution in the room was obtained through particle number concentration measurement experiment and flow simulation. The cases of operating multiple air cleaners were considered depending on whether the ventilation system and curtains were used. When two air cleaners were operated, their effects were identified by varying their positions. When only two air cleaners were used, the local age of air significantly varied by 18.3 % at maximum depending on the combination of operating positions. When all four air cleaners were operated, the age of air was lowered by 51.1 % at maximum compared to the cases of operating two air cleaners, regardless of operating the ventilation system and using the curtains. The results of this study are expected to be used for determining the optimal operating positions to improve indoor air quality when using multiple air cleaners in various indoor spaces. [ABSTRACT FROM AUTHOR]

Processing and analysis of long-term series of vertical temperature distributions in the middle atmosphere (in the altitude range of 15–60 km) over Tomsk, which were obtained on the basis of routine measurements at the lidar station of the Zuev Institute of Atmospheric Optics of the Siberian Branch of the Russian Academy of Sciences for the period 2010–2020, have been performed. Based on the experimental data, regional features of the intra- and inter-annual variability of the thermal state of the middle atmosphere over Western Siberia have been revealed, and a vertical temperature distribution in the middle atmosphere that is more appropriate to the real conditions of the region has been proposed. [ABSTRACT FROM AUTHOR]

There is nothing like a global pandemic to motivate the need for improved respiratory treatments and mucosal vaccines. Stimulated by the COVID-19 pandemic, pulmonary aerosol drug delivery has seen a flourish of activity, building on the prior decades of innovation in particle engineering, inhaler device technologies, and clinical understanding. As such, the field has expanded into new directions and is working toward the efficient delivery of increasingly complex cargos to address a wider range of respiratory diseases. This review seeks to highlight recent innovations in approaches to personalize inhalation drug delivery, deliver complex cargos, and diversify the targets treated and prevented through pulmonary drug delivery. We aim to inform readers of the emerging efforts within the field and predict where future breakthroughs are expected to impact the treatment of respiratory diseases. [ABSTRACT FROM AUTHOR]

Nebulizers generate aerosols from liquid-based solutions and suspensions. Nebulizers are particularly well suited to delivering larger doses of medication than is practical with inhalers and are used with a broad range of liquid formulations. When the same drug is available in liquid or inhaler form, nebulizers are applicable for use with patients who will not or cannot reliably use a pressurized metered-dosed inhaler (pMDI) or dry powder inhaler (DPI) due to poor lung function, hand-breath coordination, cognitive abilities (e.g., infants, elderly) or device preference. In a nebulizer, liquid medication is placed in a reservoir and fed to an aerosol generator to produce the droplets. A series of tubes and channels direct the aerosol to the patient via an interface such as mouthpiece, mask, tent, nasal prongs or artificial airway. All nebulizers contain these basic parts, although the technology and design used can vary widely and can result in significant difference in ergonomics, directions for use, and performance. While many types of nebulizers have been described, the three categories of modern clinical nebulizers include: (1) pneumatic jet nebulizers (JN); (2) ultrasonic nebulizers (USN); and (3) vibrating mesh nebulizers (VMN). Nebulizers are also described in terms of their reservoir size. Small volume nebulizers (SVNs), most commonly used for medical aerosol therapy, can hold 5 to 20 mL of medication and may be jet, ultrasonic, or mesh nebulizers. Large volume nebulizers, typically jet or ultrasonic nebulizers, hold up to 200 mL and may be used for either bland aerosol therapy or continuous drug administration. [ABSTRACT FROM AUTHOR]

Introduction: During mechanical ventilation (MV), inspired gases require heat and humidification. However, such conditions may be associated with reduced aerosol delivery efficiency. The practice of turning off heated humidification before nebulization and the impact of nebulization on humidity in a dry ventilator circuit remain topics of debate. This study aimed to assess the effect of turning off heated humidification on inhaled dose and humidity with nebulizer use during adult MV. Methods: A bronchodilator (albuterol) and two antibiotics (Colistimethate sodium and Amikacin sulfate) were nebulized with a vibrating mesh nebulizer placed at the humidifier inlet and in the inspiratory limb at the Y-piece. Additionally, albuterol was nebulized using a jet nebulizer in both placements. Aerosol particle size distribution was determined through a cascade impactor. Absolute humidity (AH) and temperature of inspired gases were determined with anemometer/hygrometers before, during, and after nebulization, before, during, and up to 60 minutes after interrupting active humidification. Aerosol collected on a filter distal to the endotracheal tube and on impactor stages were eluted and assayed by spectrophotometry. Results: The inhaled dose was greater when both nebulizers were placed at the humidifier inlet than the inspiratory limb at the Y-piece. Irrespective of the nebulizer types and placements, the inhaled dose either decreased or showed no significant change after the humidifier was turned off. The aerosol particle size ranged from 1.1 to 2.7 μm. With interruption of active humidification, humidity of inspired gas quickly dropped below recommended levels, and nebulization in dry ventilator circuit produced an AH between 10 and 20 mgH2O/L, lower than the recommended minimum of 30 mgH2O/L. Conclusion: Interrupting active humidification during MV before nebulization did not improve aerosol delivery efficiency for bronchodilator or antibiotics, but did reduce humidity below recommended levels. [ABSTRACT FROM AUTHOR]

The use of plant protection products (PPPs) has become fundamental to guarantee excellent field productivity. Nevertheless, their usage presents critical issues, such as the quantity of substances used, the relative toxicity, and the contamination of nearby fields caused by atmospheric drift. This study focuses on the characterization of aerosol droplets of PPPs produced by spraying a chemical marker, fluorescein, with an orchard airblast sprayer equipped with conventional hollow cone (HC) and anti-drift air inclusion (AI) nozzles, using a wind tunnel as a controlled environment. A particle/droplet image analysis was employed to study the droplet production of the nozzles, while a liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis allowed us to evaluate samples collected using a cascade impactor located at 5 m, 10 m, and 20 m from the emission point. Overall, HC nozzles are very accurate at producing specific drop size distributions (DSDs), while AI nozzles produce a much wider DSD, concentrating the largest part of the distributed volume into droplets of a larger size. The marker concentration was much lower for the AI nozzles compared to the HC nozzles; moreover, the two nozzles show a similar trend in the coarse droplet range, while significantly differing in the fine droplet spectrum. [ABSTRACT FROM AUTHOR]

Atmospheric ice nucleation particles (INPs) play a crucial role in influencing cloud formation and microphysical properties, which in turn impact precipitation and Earth's radiation budget. However, the influence of anthropogenic activities on the properties and concentrations of INPs remains an area of significant uncertainty. This study investigated the physical and chemical characteristics of atmospheric ice nucleation particles in Huangshan, China during the May Day labor holiday period (spanning 8 days, from April 27th to May 5th). INP concentrations were measured at temperatures from −17 °C to −26 °C and relative humidities (RHw) from 95% to 101%. Average INP concentrations reached 13.7 L−1 at −26 °C and 101% RH, 137 times higher than at −17 °C and 95% RH. INP concentrations showed exponential increases with decreasing temperature and exponential increases with increasing RH. Concentration fluctuations were observed over time, with a peak of ~30 L−1 (t = −26 °C, RHw = 101%) around the start and end of the holiday period. Aerosol number concentrations were monitored simultaneously. The peak in aerosols larger than 0.5 μm aligned with the peak in INP concentrations, suggesting a link between aerosol levels and INPs. Chemical composition analysis using SEM–EDX revealed the distinct elemental makeup of INPs based on the activation temperature. INPs active at warmer temperatures contained N, Na, and Cl, indicating possible biomass and sea salt origins, while those active at colder temperatures contained crustal elements like Al and Ca. [ABSTRACT FROM AUTHOR]

Purpose of Review: Inhaled antifungals achieve high lung concentrations with minimal systemic adverse events. Despite being available for over five decades, data supporting their use outside the mold-active prophylaxis setting are lacking. Herein, we review the recent evidence on inhaled antifungals in treating pulmonary aspergillosis (allergic, chronic, and invasive) and mucormycosis. Recent Findings: Several antifungals have recently been evaluated, including repurposed and newer inhaled agents (opelconazole). Inhaled amphotericin B deoxycholate (in pulmonary mucormycosis) and liposomal formulation (in invasive aspergillosis) were safely used in two recent randomized trials. However, both these small trials failed to demonstrate added benefit with adjunctive inhaled amphotericin. In allergic bronchopulmonary aspergillosis, nebulized amphotericin B may prolong the time-to-exacerbation when used in patients experiencing frequent exacerbations. Summary: The last decade has witnessed considerable progress in inhaled antifungals. Ongoing trials will likely offer hope for managing allergic and invasive pulmonary mycoses in the future. [ABSTRACT FROM AUTHOR]

Coronavirus disease (COVID-19) has changed the living environment in various aspects just like any other disaster. The goal of this study was to use time series remote sensing data to analyze vegetative cover change in the Western ghats of south India from January 2018 to June 2021 (pre & post covid scenario). In this context, biodiversity in terms of Normalized Differential Vegetation Index (NDVI) has been investigated in relation to variations in anthropogenic activity levels before and after the Covid-19 period. A spatio-temporal analysis of NDVI, LULC change, rainfall and AOD in relation to lockdown due to Covid-19 was conducted in this study. The study demonstrates the adaptability of remote sensing techniques and GIS for monitoring the changes in biodiversity in a more precise and cost-effective way, which is ideal for conservation planning and prioritization. Also, this study investigates the relationship between rainfall, AOD and NDVI during the study period. The results show that some parts of the Western Ghats which lies in Chamrajnagar of Karnataka, Erode and Dharmapuri of Tamil Nadu experienced significant vegetative cover change during the study period. It is also been inferred that there are changes in vegetative cover along the transect points situated in Shimoga of Karnataka, Palakkad and Idukki of Kerala due to the outbreak of forest fires. The restriction during the Covid-19 lock down has minimized the disturbance in the Ghats region which echoed in the increase in vegetative cover as well as areal extent of water bodies during post corona period (2021). The effect of increase in rainfall has reflected in the reduction in concentration of aerosol due to wet scavenging effect. [ABSTRACT FROM AUTHOR]

Due to the complex and variable nature of the atmospheric conditions, traditional multi-wavelength differential absorption lidar (DIAL) methods often suffer from significant errors when inverting ozone concentrations. As the detection range increases, there is a higher demand for Signal to Noise Ratio (SNR) in lidar signals. Based on this, the paper discusses the impact of different atmospheric factors on the accuracy of ozone concentration inversion. It also compares the advantages and disadvantages of the two-wavelength differential method and the three-wavelength dual-differential method under both noisy and noise-free conditions. Firstly, the errors caused by air molecular extinction, aerosol extinction, and backscatter terms in the inversion using the two-wavelength differential method were simulated. Secondly, the corrected inversion errors were obtained through direct correction and the introduction of a three-wavelength dual differential correction. Finally, addressing the issue of insufficient SNR in practical inversions, the inversion errors of the two correction methods were simulated by constructing lidar parameters and incorporating appropriate noise. The results indicate that the traditional two-wavelength differential algorithm is significantly affected by aerosols, making it more sensitive to aerosol concentration and structural changes. On the other hand, the three-wavelength dual differential algorithm requires a higher SNR in lidar signals. Therefore, we propose a novel strategy for inverting atmospheric ozone concentration, which prioritizes the use of the three-wavelength dual-differential method in regions with high SNR and high aerosol concentration. Conversely, the direct correction method utilizing the two-wavelength differential approach is used. This approach holds the potential for high-precision ozone concentration profile inversion under different atmospheric conditions. [ABSTRACT FROM AUTHOR]

The effects of atmospheric aerosol, including smoke, on cloudiness are of great interest for understanding the current climate changes. However, the radiative effect of Siberian biomass burning aerosol (SBBA) on clouds in the Arctic has been little studied. Based on simulation with the CHIMERE chemistry transport model and WRF meteorological model, we analyze the processes responsible for origination of the semidirect radiative effect (SDRE) of smoke from Siberian wildfires over snow–ice surfaces in the Arctic, including time- and space-averaged changes in the radiative fluxes, cloud parameters in different cloud levels, and some meteorological characteristics associated with cloud generation due to the radiative effect of (SBBA). The results show that solar radiation scattering by SBBA particles increases the static stability of the atmosphere at altitudes of 2–4 km and suppresses vertical turbulent motions, which decreases the rate of water condensation, the optical thickness of clouds, and the mixing ratio in the medium- and partly lower-level clouds. The decrease in the optical thickness of clouds, in turn, causes origination of positive SDRE of SBBA at the top and bottom of the atmosphere. Radiation absorption by SBBA particles does not play an essential role in these processes, although additionally changes meteorological characteristics. Our results expand fundamental knowledge of aerosol–cloud interactions in the Arctic and can be used for improving climate models. [ABSTRACT FROM AUTHOR]

This work presents the analysis of the spatial distribution of number concentration, size distribution, and chemical composition of aerosol particles measured for the first time over the seas of the Russian Arctic. Various types of vertical distribution of the number concentration were recorded, characteristic of both coastal marine and continental areas. Most of them turned out to be of the continental type. Attention is also drawn to the almost complete absence of coarse particles above 2–3 km over all seas. The chemical composition of the Arctic aerosol at altitudes of both 200 m and 5000 m contains ions that can be referred to as both marine and continental. The identifiable carbon- and salt-free elemental part of the aerosol over the Arctic is 3–4 times larger than that of ions. Over all seas and at both altitudes, the Arctic aerosols mainly contain elements of terrigenous origin – Al, Cu, Fe, and Si. Over almost all seas, except the Barents Sea, Si is dominant in the elemental composition of the aerosol, its contribution over the Chukchi Sea reaching 85%. The analysis of backward trajectories showed that in all cases considered, whether the aerosol was formed over the continent or sea, air trajectories passed both over sea and over land. In this case, the formed particles could be enriched with additional ions and elements along their pathway. This work completes a cycle of the papers, devoted to studying air composition, which was carried out over the seas of the Russian Arctic in September 2020. Our results can be used to model the atmospheric processes occurring in the Arctic under the conditions of changing climate. [ABSTRACT FROM AUTHOR]

This article discusses the misconceptions surrounding the use of facepiece masks for protection against viral aerosols. It explains that facepiece masks can effectively capture viral aerosols through mechanisms such as impaction, interception, diffusion, and electrophoresis. The article also highlights the benefits of wearing facepiece masks, including reducing exposure to external aerosol particles and decreasing the risk of respiratory exposure to airborne pathogens. However, it acknowledges some disadvantages of using facepiece masks, such as potential exposure to volatile chemical materials, obstruction of respiratory activities, and difficulties in communication and recognizing facial expressions. The article concludes by emphasizing the need for a balanced evaluation of the benefits and drawbacks of mandatory facepiece mask-wearing during pandemics. [Extracted from the article]

Venezuelan (VEE), eastern (EEE), and western (WEE) equine encephalitis viruses are encephalitic New World alphaviruses that cause periodic epizootic and epidemic outbreaks in horses and humans that may cause severe morbidity and mortality. Currently there are no FDA-licensed vaccines or effective antiviral therapies. Each year, there are a limited number of human cases of encephalitic alphaviruses; thus, licensure of a vaccine or therapeutic would require approval under the FDA animal rule. Approval under the FDA animal rule requires the disease observed in the animal model to recapitulate what is observed in humans. Currently, initial testing of vaccines and therapeutics is performed in the mouse model. Unfortunately, alphavirus disease manifestations in a mouse do not faithfully recapitulate human disease; the VEEV mouse model is lethal whereas in humans VEEV is rarely lethal. In an effort to identify a more appropriate small animal model, we evaluated hamsters in an aerosol exposure model of encephalitic alphavirus infection. The pathology, lethality, and viremia observed in the infected hamsters was inconsistent with what is observed in NHP models and humans. These data suggest that hamsters are not an appropriate model for encephalitic alphaviruses to test vaccines or potential antiviral therapies. [ABSTRACT FROM AUTHOR]

Most previously studies had considered that plant fungal disease spread widely and quickly by airborne fungi spore. However, little is known about the release dynamics, aerodynamic diameter, and pathogenicity threshold of fungi spore in air of the greenhouse environment. Grape gray mold is caused by Botrytis cinerea; the disease spreads in greenhouses by spores in the air and the spore attaches to the leaf and infects plant through the orifice. In this study, 120 μmol/L propidium monoazide (PMA) were suitable for treatment and quantitation viable spore by quantitative real-time PCR, with a limit detection of 8 spores/mL in spore suspension. In total, 93 strains of B. cinerea with high pathogenicity were isolated and identified from the air samples of grapevines greenhouses by a portable sampler. The particle size of B. cinerea aerosol ranged predominately from 0.65–3.3 μm, accounting for 71.77% of the total amount. The B. cinerea spore aerosols were infective to healthy grape plants, with the lowest concentration that could cause disease being 42 spores/m3. Botrytis cinerea spores collected form six greenhouse in Shandong Province were quantified by PMA-qPCR, with a higher concentration (1182.89 spores/m3) in May and June and a lower concentration in July and August (6.30 spores/m3). This study suggested that spore dispersal in aerosol is an important route for the epidemiology of plant fungal disease, and these data will contribute to the development of new strategies for the effective alleviation and control of plant diseases. [ABSTRACT FROM AUTHOR]

Speciated ground-level aerosol concentrations are required to understand and mitigate health impacts from dust storms, wildfires, and other aerosol emissions. Globally, surface monitoring is limited due to cost and infrastructure demands. While remote sensing can help estimate respirable (i.e. ground level) concentrations, current observations are restricted by inadequate spatiotemporal resolution, uncertainty in aerosol type, particle size, and vertical profile. One key issue with current remote sensing datasets is that they are derived from reflectances observed by polar-orbiting imagers, which means that aerosol is only derived during the daytime and only once or twice per day. Newer quantification methods using geostationary infrared (IR) data have focussed on detecting the presence, or absence, of an event. The determination of aerosol composition or particle size using IR exclusively has received little attention. This manuscript summarizes four scientific papers, published as part of a larger study, and identifies requirements for (a) using infrared radiance observations to obtain continual (i.e. day and night) concentration estimates; (b) increasing temporal resolution by using geostationary satellites; (c) utilizing all infrared channels to maximize spectral differences due to compositional changes; and (d) applying a high-pass filter (brightness temperature differences) to identify compositional variability. Additionally, (e) a preliminary calibration methodology was tested against three severe air quality case study incidents, namely, a dust storm, smoke from prescribed burns, and an ozone smog incident, near Sydney in eastern Australia which highlighted the ability of the method to determine atmospheric stability, clouds, and particle size. Geostationary remote sensing provides near-continuous data at a temporal resolution comparable to monitoring equipment. The spatial resolution (~ 4 km2 at NADIR) is adequate for large sources but coarse for localized sources. The spectral sensitivity of aerosol is limited and appears to be dominated by humidity changes rather than concentration or compositional changes. Geostationary remote sensing can be used to determine the timing, duration, and spatial extent of an air quality event. Brightness temperature differences can assist in qualifying composition with an order of magnitude estimate of concentration. [ABSTRACT FROM AUTHOR]

Norovirus is the leading cause of acute gastroenteritis in humans across all age groups worldwide. Norovirus-infected patients can produce aerosolized droplets which play a role in gastroenteritis transmission. The study aimed to assess bioaerosol sampling in combination with a virus concentrating procedure to facilitate molecular detection of norovirus genogroup (G) II from experimentally contaminated aerosols. Using a nebulizer within an experimental chamber, aerosols of norovirus GII were generated at known concentrations. Air samples were then collected in both 5 mL and 20 mL water using the SKC BioSampler at a flow rate of 12.5 L/min, 15 min. Subsequently, the virus in collected water was concentrated using speedVac centrifugation and quantified by RT-qPCR. The optimal distances between the nebulizer and the SKC BioSampler yielded high recoveries of the virus for both 5 and 20 mL collections. Following nebulization, norovirus GII RNA was detectable up to 120 min in 5 mL and up to 240 min in 20 mL collection. The concentrations of norovirus GII RNA recovered from air samples in the aerosol chamber ranged from 102 to 105 genome copies/mL, with average recoveries of 25 ± 12% for 5 mL and 22 ± 19% for 20 mL collections. These findings provide quantitative data on norovirus GII in aerosols and introduce a novel virus concentrating method for aerosol collection in water, thus enhancing surveillance of this virus. [ABSTRACT FROM AUTHOR]

IntroductionTuberculosis (TB) is the leading cause of death worldwide from a single infectious agent. Bacillus Calmette-Guérin (BCG), the only licensed vaccine, provides limited protection. Controlled human infection models (CHIMs) are useful in accelerating vaccine development for pathogens with no correlates of protection; however, the need for prolonged treatment makes Mycobacterium tuberculosis an unethical challenge agent. Aerosolised BCG provides a potential safe surrogate of infection. A CHIM in BCG-vaccinated as well as BCG-naïve individuals would allow identification of novel BCG-booster vaccine candidates and facilitate CHIM studies in populations with high TB endemicity. The purpose of this study was to evaluate the safety and utility of an aerosol BCG CHIM in historically BCG-vaccinated volunteers.MethodsThere were 12 healthy, historically BCG-vaccinated UK adults sequentially enrolled into dose-escalating groups. The first three received 1 × 104 CFU aerosol BCG Danish 1331 via a nebuliser. After safety review, subsequent groups received doses of 1 × 105 CFU, 1 × 106 CFU, or 1 × 107 CFU. Safety was monitored through self-reported adverse events (AEs), laboratory tests, and lung function testing. Immunology blood samples were taken pre-infection and at multiple timepoints post-infection. A bronchoalveolar lavage (BAL) taken 14 days post-infection was analysed for presence of live BCG.ResultsNo serious AEs occurred during the study. Solicited systemic and respiratory AEs were frequent in all groups, but generally short-lived and mild in severity. There was a trend for more reported AEs in the highest-dose group. No live BCG was detected in BAL from any volunteers. Aerosol BCG induced potent systemic cellular immune responses in the highest-dose group 7 days post-infection.DiscussionAerosol BCG infection up to a dose of 1 × 107 CFU was well-tolerated in historically BCG-vaccinated healthy, UK adults. No live BCG was detected in the BAL fluid 14 days post-infection despite potent systemic responses, suggesting early clearance. Further work is needed to expand the number of volunteers receiving BCG via the aerosol route to refine and establish utility of this aerosol BCG CHIM.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04777721.

The importance of aerosols (particles suspended in air) produced during dental procedures became more apparent than ever during the COVID-19 pandemic. Concerns over transmission of infection in these aerosols led to unprecedented disruption to dental services across the world, adversely impacting patients’ oral health. This article discusses the evidence related to airborne transmission of infectious diseases and the relevance to dentistry. The production of bioaerosols (aerosols carrying biological material) during dental procedures is explored, as well as how the potential risks posed by these bioaerosols can be controlled. A better understanding of dental bioaerosols is needed to prevent similar disruption to dental services in future outbreaks, and to reduce the risk of infection of dental professionals when treating patients with active infections who require urgent or emergency dental care.

Abstract Evapotranspiration (ET) is crucial for the global water balance, plant growth, and freshwater availability. It connects the surface water balance with surface energy fluxes, making its accurate representation vital for climate projections. However, global climate models (GCMs) struggle with ET representation due to resolution limitations and simplified depictions of soil, plant, and atmosphere interactions. Simulated future changes in ET are uncertain, and the role of driving processes remain unclear. Here, we explore the utility of a simple and interpretable method to disentangle these varying drivers. We investigate the sensitivity of JJA ET to different atmospheric variables through simple linear models predicting ET from atmospheric variables only. The model consistently yields good results across GCMs or forcing scenarios. We find that GCMs have shown strong decreases and subsequent increases in ET over the historical period, related to changes in net surface radiation. For future climate projections, decreases in water availability compete with higher available surface radiation, making future projections uncertain. Single forcing GCM realizations show that historical ET trends in densely populated regions have been more influenced by aerosol emissions than greenhouse gases. Finally, we investigate which atmospheric variables explain most short‐term (year‐to‐year) and long‐term (decadal) changes. While water availability may be the most important driver of short‐term variability, for certain regions, radiation trends dominate long‐term forcing. This paper leverages a simple approach to provide a comprehensive and understandable view into recent and future changes in ET, reconciling the evidence provided by more complex case studies.