51. Testing gene by community disadvantage moderation of sexual health outcomes among urban women
- Author
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Jill A. Rabinowitz, Brion S. Maher, Kelly S. Benke, George R. Uhl, Nicholas S. Ialongo, Terrinieka W. Powell, Danielle Y. Sisto, Adam J. Milam, and Michelle R. Kaufman
- Subjects
Male ,Multifactorial Inheritance ,Heredity ,Social Sciences ,law.invention ,0302 clinical medicine ,5. Gender equality ,law ,Outcome Assessment, Health Care ,Medicine and Health Sciences ,Odds Ratio ,Urban Health Services ,Medicine ,Psychology ,Ethnicities ,Public and Occupational Health ,African American people ,Reproductive health ,African american ,0303 health sciences ,Multidisciplinary ,Genomics ,Population groupings ,Moderation ,Socioeconomic Aspects of Health ,Women's Health Services ,Infectious Diseases ,Conduct disorder ,Female ,Genetic Load ,Sexual Health ,Research Article ,Science ,Sexually Transmitted Diseases ,03 medical and health sciences ,Condom ,Intervention (counseling) ,Genetics ,Genome-Wide Association Studies ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Disadvantage ,030304 developmental biology ,Behavior ,business.industry ,Urban Health ,Biology and Life Sciences ,Computational Biology ,Human Genetics ,medicine.disease ,Genome Analysis ,Health Care ,Women's Health ,Polygenic risk score ,Human Sexual Behavior ,People and places ,business ,030217 neurology & neurosurgery ,Demography - Abstract
We examined whether the interplay between community disadvantage and a conduct disorder polygenic risk score (CD PRS) was associated with sexual health outcomes among urban women. Participants (N = 511; 75.5% African American) were originally recruited to participate in a school-based intervention and were followed into adulthood. Community disadvantage was calculated using census data when participants were in first grade. At age 20, blood or saliva samples were collected and participants reported on their condom use, sexual partners, and sexually transmitted infections. A CD PRS was created based on a genome-wide association study conducted by Dick et al. [2010]. Higher levels of community disadvantage was associated with greater sexually transmitted infections among women with a higher CD PRS. Implications of the study findings are discussed.
- Published
- 2019