Search

Your search keyword '"Abounader, Roger"' showing total 429 results
Start Over Author "Abounader, Roger"
429 results on '"Abounader, Roger"'

53. Highlights from the Literature

Author

Abounader, Roger, Charest, Alain, Gerstner, Elizabeth, Ghosh, Sourav, and Soffietti, Riccardo

Subjects
Highlights, Cancer Research, Oncology, Neurology (clinical)
Published
2021

56. Highlights from the Literature

Author

Wright, Karen, Abounader, Roger, Khasraw, Mustafa, Huse, Jason, and Gerstner, Elizabeth

Subjects
Cancer Research, Oncology, Neurology (clinical), Highlights from the Literature
Published
2020

59. Highlights from the Literature

Author

Abounader, Roger, Wright, Karen, Purow, Benjamin, Hansford, Jordan R, Hwang, Eugene I, and Gottardo, Nick G

Subjects
Cancer Research, Oncology, Neurology (clinical), Highlights from the Literature
Published
2020

67. Highlights from the Literature

Author

Abounader, Roger, Bhat, Krishna, Soffietti, Riccardo, Ghosh, Sourav, and Viapiano, Mariano

Subjects
Cancer Research, Oncology, Neurology (clinical), Highlights from the Literature
Published
2019

68. Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis

Author

Reon, Brian J., Anaya, Jordan, Zhang, Ying, Mandell, James, Purow, Benjamin, Abounader, Roger, and Dutta, Anindya

Subjects
Gliomas -- Genetic aspects -- Development and progression, Gene expression -- Health aspects, RNA -- Health aspects, Biological sciences
Abstract

Background Each year, over 16,000 patients die from malignant brain cancer in the US. Long noncoding RNAs (lncRNAs) have recently been shown to play critical roles in regulating neurogenesis and brain tumor progression. To better understand the role of lncRNAs in brain cancer, we performed a global analysis to identify and characterize all annotated and novel lncRNAs in both grade II and III gliomas as well as grade IV glioblastomas (glioblastoma multiforme [GBM]). Methods and Findings We determined the expression of all lncRNAs in over 650 brain cancer and 70 normal brain tissue RNA sequencing datasets from The Cancer Genome Atlas (TCGA) and other publicly available datasets. We identified 611 induced and 677 repressed lncRNAs in glial tumors relative to normal brains. Hundreds of lncRNAs were specifically expressed in each of the three lower grade glioma (LGG) subtypes (IDH1/2 wt, IDH1/2 mut, and IDH1/2 mut 1p19q codeletion) and the four subtypes of GBMs (classical, mesenchymal, neural, and proneural). Overlap between the subtype-specific lncRNAs in GBMs and LGGs demonstrated similarities between mesenchymal GBMs and IDH1/2 wt LGGs, with 2-fold higher overlap than would be expected by random chance. Using a multivariate Cox regression survival model, we identified 584 and 282 lncRNAs that were associated with a poor and good prognosis, respectively, in GBM patients. We developed a survival algorithm for LGGs based on the expression of 64 lncRNAs that was associated with patient prognosis in a test set (hazard ratio [HR] = 2.168, 95% CI = 1.765-2.807, p < 0.001) and validation set (HR = 1.921, 95% CI = 1.333-2.767, p < 0.001) of patients from TCGA. The main limitations of this study are that further work is needed to investigate the clinical relevance of our findings, and that validation in an independent dataset is needed to determine the robustness of our survival algorithm. Conclusions This work identifies a panel of lncRNAs that appear to be prognostic in gliomas and provides a critical resource for future studies examining the role of lncRNAs in brain cancers., Author(s): Brian J. Reon 1,2, Jordan Anaya 2, Ying Zhang 3, James Mandell 1, Benjamin Purow 3, Roger Abounader 3, Anindya Dutta 2,* Introduction Malignant gliomas are the most common [...]

Published
2016
Full Text
View/download PDF

69. Highlights from the Literature

Author

Viapiano, Mariano, Bhat, Krishna, Abounader, Roger, Wright, Karen, Wick, Wolfgang, and Purow, Benjamin

Subjects
Cancer Research, Oncology, Neurology (clinical), Highlights from the Literature
Published
2017

74. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells

Author

Bannon, Desmond I., Abounader, Roger, Lees, Peter S.J., and Bressler, Joseph P.

Subjects
Intestines -- Physiological aspects, Biological transport -- Research, Iron in the body -- Physiological aspects, Cadmium -- Physiological aspects, Biological sciences
Abstract

DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead. Wild-type Caco-2 cells displayed saturable transport of lead and iron that was stimulated by acid. Cadmium and manganese inhibited transport of iron, but zinc and lead did not. The involvement of DMT1 in the transport of toxic metals was examined by establishing clonal DMT1 knockdown and control Caco-2 cell lines. Knockdown cell lines displayed much lower levels of DMT1 mRNA and a smaller [V.sub.max] for iron uptake compared with control cell lines. One clone was further characterized and found to display an ~50% reduction in uptake of iron across a pH range from 5.5 to 7.4. Uptake for cadmium also decreased 50% across the same pH range, but uptake for lead did not. These results show that DMT1 is important in iron and cadmium transport in Caco-2 cells but that lead enters these cells through an independent hydrogen-driven mechanism. divalent metal transporter 1; transport; intestine

Published
2003

76. Highlights from the Literature

Author

Viapiano, Mariano, primary, Abounader, Roger, primary, Charest, Alain, primary, Gerstner, Elizabeth, primary, Soffietti, Riccardo, primary, and Aldape, Kenneth, primary

Published
2020
Full Text
View/download PDF

78. Highlights from the literature

Author

Wick, Wolfgang, primary, Abounader, Roger, primary, Charest, Alain, primary, Lindsay, Holly, primary, Chintagumpala, Murali, primary, Mack, Stephen C, primary, and Aldape, Kenneth, primary

Published
2020
Full Text
View/download PDF

82. Highlights from the Literature

Author

Soffietti, Riccardo, primary, Wick, Wolfgang, additional, Purow, Benjamin, additional, Abounader, Roger, additional, Khasraw, Mustafa, additional, and Aldape, Kenneth, additional

Published
2019
Full Text
View/download PDF

85. Highlights from the Literature

Author

Abounader, Roger, Wright, Karen, Bhat, Krishna, Chamberlain, Marc, Purow, Benjamin, and Soffietti, Riccardo

Subjects
Highlights, Cancer Research, Oncology, Neurology (clinical)
Published
2017

87. Highlights from the Literature

Author

Wick, Wolfgang, Soffietti, Riccardo, Bhat, Krishna, Abounader, Roger, and Pope, Whitney

Subjects
Cancer Research, Oncology, Neurology (clinical), Highlights from the Literature
Published
2018

88. THE RISING WORLD OF MICRORNAS:ONCOGENES AND TUMOR SUPPRESSORS IN CANCER

Author

GUESSOUS, Fadila, ZHANG, Ying, and ABOUNADER, Roger

Subjects
Glioblastoma, glioma, microRNA, glioma stem cells, drug resistance
Abstract

The sequencing of the human genome has revealed that the bulk of the genome is transcribed into noncoding RNAs, including microRNAs. These microRNAs are deregulated in cancer where they regulate a wide array of functions associated with tumorigenesis. Glioblastoma (GBM) is the most common and aggressive primary intracranial tumor of the adult brain. miRNAs are short noncoding RNAs that broadly regulate gene expression. They exert their actions via transcriptional, post-transcriptional, and epigenetic mechanisms that are poorly understood. Numerous miRNAs are deregulated in GBM, where their expression levels can serve as biomarkers. They can act as either oncogenes or tumor suppressors in GBM by targeting the expression of numerous tumor-suppressors or oncogenes. miRNAs regulate all GBM malignancy aspects including cell proliferation, survival, motility, migration, invasion, angiogenesis, cancer stem cell biology, microenvironment modulation, immune escape, and therapy resistance. MiRNAs can also be secreted via exosomes or microvesicles in body .uids, where they can be used as diagnosis and/or prognosis biomarkers. Considering their deep involvement in GBM malignancy, numerous studies are currently undertaken to exploit miRNAs as therapeutic agents or targets. This short review summarizes the biogenesis, deregulation, functions, mechanisms of action, and clinical applications of miRNAs in GBM, Frontiers in Science and Engineering, Vol 8, Supplment 2 (2019)

Published
2019
Full Text
View/download PDF

89. Highlights from the Literature

Author

Viapiano, Mariano, Bhat, Krishna, Abounader, Roger, Huse, Jason, and Hegi, Monika

Subjects
Highlights from the Literature
Published
2018

90. Parallel changes of blood flow and heterogeneity of capillary plasma perfusion in rat brains during hypocapnia

Author

Vogel, Johannes, Abounader, Roger, Schrock, Helmut, Zeller, Karin, Duelli, Roman, and Kuschinsky, Wolfgang

Subjects
Cerebral circulation -- Research, Blood flow -- Research, Biological sciences
Abstract

Blood flow is not distributed evenly in the brain at all times, so that capillaries are not all filled at the same time. The patterns of perfusion in brain capilalries were studied in rat brains whose blood flow was reduced to see if these patterns change as blood supply is changed. Evans blue dye was introduced intravenously, then the rats were decapitated and the heads were frozen and examined for variations in dye concentration in the capillaries. When the dye was introduced to blood vessels under conditions of hypocapnia, they showed a more homogenous distribution of dye compared to patterns observed in normocapnia and hypercapnia.

Published
1996

91. Highlights from the Literature

Author

Wright, Karen, Abounader, Roger, Bhat, Krishna, Viapiano, Mariano S., Pope, Whitney, and Aldape, Kenneth

Subjects
Highlights, Cancer Research, Oncology, Neurology (clinical)
Published
2017

94. Highlights from the Literature

Author

Pope, Whitney, Huse, Jason, Abounader, Roger, Purow, Benjamin, Wick, Wolfgang, and Aldape, Kenneth

Subjects
Highlights, Cancer Research, Oncology, Neurology (clinical)
Published
2016

98. Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma

Author

Cruickshanks, Nichola, primary, Zhang, Ying, additional, Hine, Sarah, additional, Gibert, Myron, additional, Yuan, Fang, additional, Oxford, Madison, additional, Grello, Cassandra, additional, Pahuski, Mary, additional, Dube, Collin, additional, Guessous, Fadila, additional, Wang, Baomin, additional, Deveau, Ciana, additional, Saoud, Karim, additional, Gallagher, Isela, additional, Wulfkuhle, Julia, additional, Schiff, David, additional, Phan, See, additional, Petricoin, Emanuel, additional, and Abounader, Roger, additional

Published
2019
Full Text
View/download PDF

100. 5th International Symposium on Focused Ultrasound

Author

Abounader, Roger, Abraham, Christopher, Adema, Gosse, Agrawal, Punit, Airan, Raag, Aleman, Dionne, Alexander, Phillip, Alkins, Ryan, Alnazeer, Moez, Altman, Michael, Aly, Amirah, Amaral, Joao G., Amrahli, Maral, Amraoui, Sana, Andarawewa, Kumari, Andriyakhina, Yulia, Angstadt, Mary, Ankou, Bénédicte, Arias, Ana C., Arvanitis, Costas, Asadnia, Kiana, Aubert, Isabelle, Aubry, Jean-Francois, Aurup, Christian, Bader, Kenneth, Badr, Lena, Baek, Hongchae, Barbato, Gaetano, Beccaria, Kevin, Bellorofonte, Carlo, Benson, Lee, Bernus, Olivier, Berriet, Rémi, Bertolina, Jim, Beskin, Viktoriya, Bessière, Francis, Bethune, Allison, Bezzi, Mario, Bond, Aaron, Bonomo, Guido, Borowsky, Alexander, Borys, Nicolas, Böttcher, Joachim, Bouley, Donna, Bour, Pierre, Bourekas, Eric, Brenin, David, Brokman, Omer, Brosh, Inbar, Buckner, Andrew, Bullock, Timothy, Cafarelli, Andrea, Cahill, Jessica, Camarena, Francisco, Camelo-Piragua, Sandra, Campbell, Benjamin, Campbell, Fiona, Cannata, Jon, Canney, Michael, Carlson, Roy, Carneiro, Antonio, Carpentier, Alexandre, Catheline, Stefan, Cavin, Ian, Cesana, Claudio, Chabok, Hamid R., Chamanara, Marzieh, Chang, Jin H., Chang, Won S., Changizi, Barbara, Chapelon, Jean Y., Chaplin, Vandiver, Chapman, Martin, Chaudhary, Neeraj, Chaussy, Christian, Chen, Cherry, Chen, Johnny, Chen, Wohsing, Chen, Xiaoming, Chevalier, Philippe, Chiou, George, Chisholm, Alexander, Christofferson, Ivy, Chung, Hyun H., Ciuti, Gastone, Clement, Gregory, Cooper, Mark, Corea, Joseph, Corso, Cristiano, Cosman, Josh, Coughlin, Dezba, Crake, Calum, Cunitz, Bryan, Curiel, Laura, Curley, Colleen T., Czarnota, Gregory, Dababou, Susan, Dallapiazza, Robert, de Bever, Joshua, de Jager, Bram, de Ruiter, Joost, de Senneville, Baudouin D., Deckers, Roel, Delattre, Jean-Yves, den Brok, Martijn, Dhanaliwala, Ali, Diodato, Alessandro, Dixon, Adam, Donner, Elizabeth, Downs, Matthew, Du, Zhongmin, Dubois, Rémi, Dupre, Aurelien, Eikelenboom, Dylan, Elias, W. J., Ellens, Nicholas, Endre, Ruby, Eran, Ayelet, Erasmus, Hans-Peter, Everstine, Ashli, Farahani, Keyvan, Farrer, Alexis, Farry, Justin, Federau, Christian, Feng, Xue, Ferrer, Cyril, Ferrera, Vincent, Fishman, Paul, Foley, Jessica, Frenkel, Victor, Fütterer, Jurgen, Gach, H. M., Gandhi, Dheeraj, Gertner, Michael, Goldsher, Dorit, Gorgone, Alessandro, Greillier, Paul, Griesenauer, Rebekah, Grissom, William, Grondin, Julien, Guha, Chandan, Gulati, Amitabh, Gullapalli, Rao, Guo, Sijia, Gupta, Samit, Gurm, Hitinder, Gwinn, Ryder, Hadley, Rock, Haïssaguerre, Michel, Hammoud, Dima, Hananel, Arik, Hargrove, Amelia, Hatch, Robert, Haworth, Kevin, Hazan, Eilon, He, Ye, Heemels, Maurice, Heerschap, Arend, Hilas, Elaine, Hoang-Xuan, Khe, Hocini, Mélèze, Hodaie, Mojgan, Hofmann, Denis, Holland, Christy, Hoogenboom, Martijn, Hopyan, Sevan, Hossack, John, Houdouin, Alexandre, Hsu, Po-Hung, Hu, Jim, Hurwitz, Mark, Huss, Diane, Hwang, Chang-il, Hwang, Joo H., Idbaih, Ahmed, Ikeuchi, Masahiko, Ingham, Elizabeth, Ives, Kimberly, Izumi, Masashi, Jackson-Lewis, Vernice, Janát-Amsbury, Margit, Jang, Kee W., Jedruszczuk, Kathleen, Jiménez-Gambín, Sergio, Jiménez, Noé, Johnson, Sara, Jonathan, Sumeeth, Joy, Joyce, Jung, Hyun H., Jung, Na Y., Kahn, Itamar, Kamimura, Hermes, Kamrava, Seyed K., Kang, Jeeun, Kang, Kook J., Kang, Soo Y., Kao, Yi-tzu, Katti, Prateek, Kawasaki, Motohiro, Kaye, Elena, Keupp, Jochen, Kim, AeRang, Kim, Harry, Kim, Hyun-Chul, Kim, Hyuncheol, Kim, Hyungmin, Kim, Min S., Kim, Namho, Kiyasu, Katsuhito, Kneepkens, Esther, Knopp, Michael, Kobus, Thiele, Koral, Korgun, Kreider, Wayne, Krishna, Vibhor, Krug, Roland, Krupa, Steve, Kuo, Chia-Chun, Kwiecinski, Wojciech, Lacoste, Romain, Lam, Heather, Lamberti-Pasculli, Maria, Lang, Brian, Larner, James, Larrabee, Zachary, Leach, J. K., LeBlang, Suzanne, Leclercq, Delphine, Lee, Hak J., Lee, Jong-Hwan, Lehericy, Stéphane, Leighton, Wan, Leung, Steven, Lewis, Bobbi, Lewis, Matthew, Li, Dawei, Linn, Sabine, Lipsman, Nir, Liu, Hao-Li, Liu, Jingfei, Lopes, M. B., Lotz, Jeff, Lu, Xin, Lundt, Jonathan, Luo, Xi, Lustgarten, Lior, Lustig, Micheal, Macoskey, Jonathan, Madore, Bruno, Maev, Roman, Magat, Julie, Maimbourg, Guillaume, Maimon, Noam, Mainprize, Todd, Malayer, Jerry, Maples, Danny, Marquet, Fabrice, Marrocchio, Cristina, Marx, Mike, Mastorakos, Panagiotis, Mauri, Giovanni, McLean, Hailey, McMichael, John, Mead, Brian P., Melodelima, David, Melot-Dusseau, Sandrine, Menciassi, Arianna, Merrill, Robb, Meyer, Joshua, Midiri, Massimo, Miga, Michael, Migliore, Ilaria G., Miller, Eric, Minalga, Emilee, Moon, Hyungwon, Moore, David, Mourad, Pierre, Mouratidis, Petros, Mueller, Michael, Mugler, John, Muller, Sébastien, Namba, Hirofumi, Naor, Omer, Nassar, Maria, Nazai, Navid, Negron, Karina, Negussie, Ayele, Nguyen, Thai-Son, Nicolay, Klaas, Nikolaeva, Anastasia V., Oetgen, Matthew, Olive, Kenneth, Olumolade, Oluyemi, Orsi, Franco, Owens, Gabe, Ozilgen, Arda, Padegimas, Linas, Palermo, Carmine, Pan, Chia-Hsin, Pandey, Aditya, Papadakis, Georgios, Park, Chang K., Park, Sang M., Parker, Jonathon, Parvizi, Mohammad H., Pascal-Tenorio, Aurea, Patel, Janish, Patz, Sam, Payen, Thomas, Perich, Eloi, Pernot, Mathieu, Perol, David, Perry, James, Pillarisetty, Venu, Pioche, Mathieu, Pizzuto, Matthew, Plaksin, Michael, Plata, Juan, Price, Karl, Prince, Jessica, Przedborski, Serge, Quinones-Hinojosa, Alfredo, Ramachandran, Akhilesh, Ranjan, Ashish, Ravikumar, Vinod, Reichenbach, Juergen, Repasky, Elizabeth, Rezai, Ali, Ritter, Philippe, Rivoire, Michel, Rochman, Carrie, Rosenberg, Jarrett, Rosnitskiy, Pavel B., Ruiz, Antonio, Sahgal, Arjun, Samiotaki, Gesthimani, Sanghvi, Narendra, Santin, Mathieu D., Santos, Domiciano, Sasaki, Noboru, Sastra, Steve, Schade, George, Schall, Jeffrey, Schlesinger, Ilana, Schmitt, Paul, Schwaab, Julia, Scionti, Stephen, Scipione, Roberto, Scoarughi, Gian L., Scott, Serena, Sebeke, Lukas, Seifabadi, Reza, Seo, Jai, Sesenoglu-Laird, Ozge, Shah, Binit, Shahriari, Kian, Shaikh, Sumbul, Shea, Jill, Shi, Jiaqi, Shim, Jenny, Shinkov, Alexander, Shuman, Jillian, Silvestrini, Matthew, Sim, Changbeom, Sin, Vivian, Sinai, Alon, Singh, Manoj, Sinilshchikov, Ilya, Skalina, Karin, Slingluff, Craig, So, Po-Wah, Solomon, Stephen, Son, Keon H., Sperling, Scott, Stein, Ruben, Stein, Sherman, Stevens, Aaron, Stimec, Jennifer, Storm, Gert, Straube, William, Suelmann, Britt, Sutton, Jonathan, Svedin, Bryant, Takemasa, Ryuichi, Takiguchi, Mitsuyoshi, Tam, Emily, Tan, Jeremy, Tang, Xinyan, Tanter, Mickael, Tebebi, Pamela, Tehrani, Seruz, Temple, Michael, Teofilovic, Dejan, ter Haar, Gail, Terzi, Marina E., Thueroff, Stefan, Timbie, Kelsie, Tognarelli, Selene, Tretbar, Steffen, Trudeau, Maureen, Tsai, Yi-Chieh, Tsysar, Sergey A., Tucci, Samantha, Tuveson, David, Ushida, Takahiro, Vaessen, Paul, Vaillant, Fanny, Van Arsdell, Glen, van Breugel, Johanna, Van der Jeugd, Anneke, Van der Wall, Elsken, van Diest, Paul, van Stralen, Marijn, Varano, Gianluca, Velat, Manuela, Vidal-Jove, Joan, Vigna, Paolo D., Vignot, Alexandre, Vincenot, Jeremy, Vykhodtseva, Natalia, Wang, Bin, Wang, Han, Wang, Kevin, Wang, Qi, Wang, Qingguo, Wang, Shengping, Wang, Yak-Nam, Wang, Zhaorui, Wardlow, Rachel, Warren, Amy, Waszczak, Barbara, Watson, Katherine, Webb, Taylor, Wei-Bin, Shen, Wei, Kuo-Chen, Weiss, Steffen, Weissler, Yoni, Werner, Beat, Wesseling, Pieter, Williams, Noelle, Wilson, Emmanuel, Wintermark, Max, Witkamp, Arjen, Wong, Carlos, Wu, Jing-Fu, Wydra, Adrian, Xu, Alexis, Xu, Doudou, Xu, Su, Yang, Georgiana, Yang, Nai-Yi, Yao, Chen, Yarowsky, Paul, Ye, Patrick P., Yuldashev, Petr, Zaaroor, Menashe, Zachiu, Cornel, Zahos, Peter, Zangos, Stephan, Zhang, Dandan, Zhang, Hua, Zhang, Jimin, Zhang, Junhai, Zhang, Xi, Zhao, Li, Zhong, Pei, Zhuo, Jiachen, Zidowitz, Stephan, Zinke, Wolf, Zorgani, Ali, and Aerospace and Ocean Engineering

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Published version

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results