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51. Measurements of Cosmic-Ray Low-Energy Antiproton and Proton Spectra in a Transient Period of Solar Field Reversal

Author

浅岡, 陽一, 志風, 義明, 安部, 航, 安楽, 和明, 藤川, 元治, 福家, 英之, 灰野, 禎一, 井森, 正敏, 泉, 康介, 前野, 忠嗣, 槙田, 康博, 松田, 晋弥, 松井, 長隆, 松川, 武夫, 松本, 浩, 松永, 浩之, Mitchell, J., 三井, 唯夫, Moiseev, A., 元木, 正和, 西村, 純, 野崎, 光昭, 折戸, 周治, Ormes, J. F., 佐伯, 学行, 佐貫, 智行, 佐々木, 誠, Seo, E. S., 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 谷崎, 圭祐, 上田, 郁夫, Wang, J. Z., 矢島, 信之, 山上, 隆正, 山本, 明, 山本, 康史, 大和, 一洋, 吉田, 哲也, 吉村, 浩司, Asaoka, Yoichi, Shikaze, Yoshiaki, Abe, Koh, Anraku, Kazuaki, Fujikawa, Motoharu, Fuke, Hideyuki, Haino, Sadakazu, Imori, Masatoshi, Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsui, Nagataka, Matsukawa, Takeo, Matsumoto, Hiroshi, Matsunaga, Hiroyuki, Mitsui, Tadao, Motoki, Masakazu, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Saeki, Takayuki, Sanuki, Tomoyuki, Sasaki, Makoto, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Tanizaki, Keisuke, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, Yoshimura, Koji, 浅岡, 陽一, 志風, 義明, 安部, 航, 安楽, 和明, 藤川, 元治, 福家, 英之, 灰野, 禎一, 井森, 正敏, 泉, 康介, 前野, 忠嗣, 槙田, 康博, 松田, 晋弥, 松井, 長隆, 松川, 武夫, 松本, 浩, 松永, 浩之, Mitchell, J., 三井, 唯夫, Moiseev, A., 元木, 正和, 西村, 純, 野崎, 光昭, 折戸, 周治, Ormes, J. F., 佐伯, 学行, 佐貫, 智行, 佐々木, 誠, Seo, E. S., 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 谷崎, 圭祐, 上田, 郁夫, Wang, J. Z., 矢島, 信之, 山上, 隆正, 山本, 明, 山本, 康史, 大和, 一洋, 吉田, 哲也, 吉村, 浩司, Asaoka, Yoichi, Shikaze, Yoshiaki, Abe, Koh, Anraku, Kazuaki, Fujikawa, Motoharu, Fuke, Hideyuki, Haino, Sadakazu, Imori, Masatoshi, Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsui, Nagataka, Matsukawa, Takeo, Matsumoto, Hiroshi, Matsunaga, Hiroyuki, Mitsui, Tadao, Motoki, Masakazu, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Saeki, Takayuki, Sanuki, Tomoyuki, Sasaki, Makoto, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Tanizaki, Keisuke, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, and Yoshimura, Koji more...

Abstract

著者人数: 42名

Published
2015

52. Precision Measurement of Cosmic-Ray Antiproton Spectrum

Author

折戸, 周治, 前野, 忠嗣, 松永, 浩之, 安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 井森, 正敏, 石野, 雅也, 槙田, 康博, 松井, 長隆, 松本, 浩, Mitchell, J., 三井, 唯夫, Moiseev, A., 元木, 正和, 西村, 純, 野崎, 光昭, Ormes, J., 佐伯, 学行, 佐貫, 智行, 佐々木, 誠, Seo, E. S., 志風, 義明, 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 上田, 郁夫, 矢島, 信之, 山上, 隆正, 山本, 明, 吉田, 哲也, 吉村, 浩司, Orito, Shuji, Maeno, Tadashi, Matsunaga, Hiroyuki, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Imori, Masatoshi, Ishino, Masaya, Makida, Yasuhiro, Matsui, Nagataka, Matsumoto, Hiroshi, Mitsui, Tadao, Motoki, Masakazu, Nishimura, Jun, Nozaki, Mitsuaki, Saeki, Takayuki, Sanuki, Tomoyuki, Sasaki, Makoto, Shikaze, Yoshiaki, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yoshida, Tetsuya, Yoshimura, Koji, 折戸, 周治, 前野, 忠嗣, 松永, 浩之, 安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 井森, 正敏, 石野, 雅也, 槙田, 康博, 松井, 長隆, 松本, 浩, Mitchell, J., 三井, 唯夫, Moiseev, A., 元木, 正和, 西村, 純, 野崎, 光昭, Ormes, J., 佐伯, 学行, 佐貫, 智行, 佐々木, 誠, Seo, E. S., 志風, 義明, 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 上田, 郁夫, 矢島, 信之, 山上, 隆正, 山本, 明, 吉田, 哲也, 吉村, 浩司, Orito, Shuji, Maeno, Tadashi, Matsunaga, Hiroyuki, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Imori, Masatoshi, Ishino, Masaya, Makida, Yasuhiro, Matsui, Nagataka, Matsumoto, Hiroshi, Mitsui, Tadao, Motoki, Masakazu, Nishimura, Jun, Nozaki, Mitsuaki, Saeki, Takayuki, Sanuki, Tomoyuki, Sasaki, Makoto, Shikaze, Yoshiaki, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yoshida, Tetsuya, and Yoshimura, Koji more...

Abstract

著者人数: 34名

Published
2015

53. BESS-Polar Experiment

Author

吉田, 哲也, 山本, 明, Mitchell, J., 安部, 航, 福家, 英之, 灰野, 禎一, Hams, T., 池田, 伸穂, 板崎, 輝, 泉, 康介, Lee, M. H., 前野, 忠嗣, 槙田, 康博, 松田, 晋弥, 松本, 浩, Moiseev, A., 西村, 純, 野崎, 光昭, 大宮, 英紀, Ormes, J. F., 佐々木, 誠, Seo, E. S., 志風, 義明, Stephens, A., Streitmatter, R. E., 鈴木, 純一, 高杉, 佳幸, 田中, 賢一, 谷崎, 圭祐, 山上, 隆正, Yoshida, Tetsuya, Yamamoto, Akira, Abe, Koh, Fuke, Hideyuki, Haino, Sadakazu, Ikeda, Nobuho, Itasaki, A., Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsumoto, Hiroshi, Nishimura, Jun, Nozaki, Mitsuaki, Omiya, Hideki, Sasaki, Makoto, Shikaze, Yoshiaki, Suzuki, Junichi, Takasugi, Yoshiyuki, Tanaka, Kenichi, Tanizaki, Keisuke, Yamagami, Takamasa, 吉田, 哲也, 山本, 明, Mitchell, J., 安部, 航, 福家, 英之, 灰野, 禎一, Hams, T., 池田, 伸穂, 板崎, 輝, 泉, 康介, Lee, M. H., 前野, 忠嗣, 槙田, 康博, 松田, 晋弥, 松本, 浩, Moiseev, A., 西村, 純, 野崎, 光昭, 大宮, 英紀, Ormes, J. F., 佐々木, 誠, Seo, E. S., 志風, 義明, Stephens, A., Streitmatter, R. E., 鈴木, 純一, 高杉, 佳幸, 田中, 賢一, 谷崎, 圭祐, 山上, 隆正, Yoshida, Tetsuya, Yamamoto, Akira, Abe, Koh, Fuke, Hideyuki, Haino, Sadakazu, Ikeda, Nobuho, Itasaki, A., Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsumoto, Hiroshi, Nishimura, Jun, Nozaki, Mitsuaki, Omiya, Hideki, Sasaki, Makoto, Shikaze, Yoshiaki, Suzuki, Junichi, Takasugi, Yoshiyuki, Tanaka, Kenichi, Tanizaki, Keisuke, and Yamagami, Takamasa more...

Abstract

著者人数: 33名, Accepted: 2003-05-02

Published
2015

54. New Measurement of Primary Cosmic-rays and Atmospheric Muons with BESS-TeV Spectrometer

Author

安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 福家, 英之, 灰野, 禎一, 井森, 正敏, 泉, 康介, 松田, 晋弥, 松井, 長隆, 松本, 浩, 元木, 正和, 西村, 純, 折戸, 周治, 佐貫, 智行, 園田, 友博, 山本, 康史, 槇田, 康博, 鈴木, 純一, 田中, 賢一, 山本, 明, 吉田, 哲也, 吉村, 浩司, Mitchell, J. W., Moiseev, A. A., Ormes, J. F., 佐々木, 誠, Streitmatter, R. E., 前野, 忠嗣, 松川, 武夫, 野崎, 光昭, 志風, 義明, 谷崎, 圭祐, 大和, 一洋, Seo, E. S., 山上, 隆正, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Fuke, Hideyuki, Haino, Sadakazu, Imori, Masatoshi, Izumi, Kosuke, Matsuda, Shinya, Matsui, Nagataka, Matsumoto, Hiroshi, Motoki, Masakazu, Nishimura, Jun, Orito, Shuji, Sanuki, Tomoyuki, Sonoda, Tomohiro, Yamamoto, Yasuchika, Makida, Yasuhiro, Suzuki, Junichi, Tanaka, Kenichi, Yamamoto, Akira, Yoshida, Tetsuya, Yoshimura, Koji, Sasaki, Makoto, Maeno, Tadashi, Matsukawa, Takeo, Nozaki, Mitsuaki, Shikaze, Yoshiaki, Tanizaki, Keisuke, Yamato, Kazuhiro, Yamagami, Takamasa, 安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 福家, 英之, 灰野, 禎一, 井森, 正敏, 泉, 康介, 松田, 晋弥, 松井, 長隆, 松本, 浩, 元木, 正和, 西村, 純, 折戸, 周治, 佐貫, 智行, 園田, 友博, 山本, 康史, 槇田, 康博, 鈴木, 純一, 田中, 賢一, 山本, 明, 吉田, 哲也, 吉村, 浩司, Mitchell, J. W., Moiseev, A. A., Ormes, J. F., 佐々木, 誠, Streitmatter, R. E., 前野, 忠嗣, 松川, 武夫, 野崎, 光昭, 志風, 義明, 谷崎, 圭祐, 大和, 一洋, Seo, E. S., 山上, 隆正, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Fuke, Hideyuki, Haino, Sadakazu, Imori, Masatoshi, Izumi, Kosuke, Matsuda, Shinya, Matsui, Nagataka, Matsumoto, Hiroshi, Motoki, Masakazu, Nishimura, Jun, Orito, Shuji, Sanuki, Tomoyuki, Sonoda, Tomohiro, Yamamoto, Yasuchika, Makida, Yasuhiro, Suzuki, Junichi, Tanaka, Kenichi, Yamamoto, Akira, Yoshida, Tetsuya, Yoshimura, Koji, Sasaki, Makoto, Maeno, Tadashi, Matsukawa, Takeo, Nozaki, Mitsuaki, Shikaze, Yoshiaki, Tanizaki, Keisuke, Yamato, Kazuhiro, and Yamagami, Takamasa more...

Abstract

著者人数: 36名

Published
2015

55. Precise Measurement of Cosmic-Ray Proton and Helium Spectra with the BESS Spectrometer

Author

佐伯, 学行, 元木, 正和, 松本, 浩, Seo, E. S., Wang, J. Z., 安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 井森, 正敏, 前野, 忠嗣, 槙田, 康博, 松井, 長隆, 松永, 浩之, Mitchell, J., 三井, 唯夫, Moiseev, A., 西村, 純, 野崎, 光昭, 折戸, 周治, Ormes, J., 佐々木, 誠, 志風, 義明, 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 上田, 郁夫, 矢島, 信之, 山上, 隆正, 山本, 明, 吉田, 哲也, 吉村, 浩司, Saeki, Takayuki, Motoki, Masakazu, Matsumoto, Hiroshi, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Imori, Masatoshi, Maeno, Tadashi, Makida, Yasuhiro, Matsui, Nagataka, Matsunaga, Hiroyuki, Mitsui, Tadao, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Sasaki, Makoto, Shikaze, Yoshiaki, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yoshida, Tetsuya, Yoshimura, Koji, 佐伯, 学行, 元木, 正和, 松本, 浩, Seo, E. S., Wang, J. Z., 安部, 航, 安楽, 和明, 浅岡, 陽一, 藤川, 元治, 井森, 正敏, 前野, 忠嗣, 槙田, 康博, 松井, 長隆, 松永, 浩之, Mitchell, J., 三井, 唯夫, Moiseev, A., 西村, 純, 野崎, 光昭, 折戸, 周治, Ormes, J., 佐々木, 誠, 志風, 義明, 園田, 友博, Streitmatter, R., 鈴木, 純一, 田中, 賢一, 上田, 郁夫, 矢島, 信之, 山上, 隆正, 山本, 明, 吉田, 哲也, 吉村, 浩司, Saeki, Takayuki, Motoki, Masakazu, Matsumoto, Hiroshi, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fujikawa, Motoharu, Imori, Masatoshi, Maeno, Tadashi, Makida, Yasuhiro, Matsui, Nagataka, Matsunaga, Hiroyuki, Mitsui, Tadao, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Sasaki, Makoto, Shikaze, Yoshiaki, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yoshida, Tetsuya, and Yoshimura, Koji more...

Abstract

著者人数: 34名, Accepted: 2000-08-07

Published
2015

56. GLD Detector Outline Document

Author

Abe, Koh

Subjects
Physics::Instrumentation and Detectors, Other Fields of Physics, High Energy Physics::Experiment
Abstract

The GLD is a detector for the experiment at the International Linear Collider (ILC). It consists of a large calorimeter and a gaseous central tracker placed in a moderate magnetic field, both electro-magnetic and hadron calorimeters being placed inside the magnetic coil to have enough hermeticity and good jet energy resolution. The outline of the GLD is presented. more...

Published
2006

57. Search for Cosmic-Ray Antideuterons

Author

Mitchell, J. W., Moiseev, A. A., Ormes, J. F., Seo, E. S., Streitmatter, R. E., Fuke, Hideyuki, Maeno, Tadashi, Abe, Koh, Haino, Sadakazu, Makida, Yasuhiro, Matsuda, Shinya, Matsumoto, Hiroshi, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Sasaki, Makoto, Shikaze, Yoshiaki, Suzuki, Junichi, Tanaka, Kenichi, Tanizaki, Keisuke, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, and Yoshimura, Koji more...

Subjects
Physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics (astro-ph), General Physics and Astronomy, Flux, FOS: Physical sciences, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Nuclear physics, Atmosphere of Earth, High Energy Physics::Experiment, Nucleon, Nuclear Experiment
Abstract

We performed a search for cosmic-ray antideuterons using data collected during four BESS balloon flights from 1997 to 2000. No candidate was found. We derived, for the first time, an upper limit of 1.9E-4 (m^2 s sr GeV/nucleon)^(-1) for the differential flux of cosmic-ray antideuterons, at the 95% confidence level, between 0.17 and 1.15 GeV/nucleon at the top of the atmosphere., Comment: 4 pages, 3 figures, submitted to Phys. Rev. Lett more...

Published
2005
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58. Measurements of Proton, Helium and Muon Spectra at Small Atmospheric Depths with the BESS Spectrometer

Author

Mitchell, J. W., Moiseev, A. A., Ormes, J. F., Seo, E. S., Streitmatter, R. E., Abe, Koh, Sanuki, Tomoyuki, Anraku, Kazuaki, Asaoka, Yoichi, Fuke, Hideyuki, Haino, Sadakazu, Ikeda, Nobuho, Imori, Masatoshi, Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsui, Nagataka, Matsukawa, Takeo, Matsumoto, Hiroshi, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Sasaki, Makoto, Shikaze, Yoshiaki, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Tanizaki, Keisuke, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, and Yoshimura, Koji more...

Subjects
Physics, Nuclear and High Energy Physics, Muon, Proton, Spectrometer, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics (astro-ph), Hadron, FOS: Physical sciences, chemistry.chemical_element, Cosmic ray, Astrophysics, Spectral line, Nuclear physics, Atmosphere, chemistry, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Helium, Physics::Atmospheric and Oceanic Physics
Abstract

著者人数: 35名, Accepted: 2003-05-06, 資料番号: SA1003536000

Published
2003

59. Measurements of Cosmic-ray Low-energy Antiproton and Proton Spectra in a Transient Period of the Solar Field Reversal

Author

Mitchell, J., Moiseev, A., Ormes, J. F., Seo, E. S., Streitmatter, R., Wang, J. Z., Asaoka, Yoichi, Shikaze, Yoshiaki, Abe, Koh, Anraku, Kazuaki, Fujikawa, Motoharu, Fuke, Hideyuki, Haino, Sadakazu, Imori, Masatoshi, Izumi, Kosuke, Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsui, Nagataka, Matsukawa, Takeo, Matsumoto, Hiroshi, Matsunaga, Hiroyuki, Mitsui, Tadao, Motoki, Masakazu, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Saeki, Takayuki, Sanuki, Tomoyuki, Sasaki, Makoto, Sonoda, Tomohiro, Suzuki, Junichi, Tanaka, Kenichi, Tanizaki, Keisuke, Ueda, Ikuo, Yajima, Nobuyuki, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, and Yoshimura, Koji more...

Subjects
Physics, Period (periodic table), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Astrophysics (astro-ph), General Physics and Astronomy, FOS: Physical sciences, Cosmic ray, Astrophysics, 01 natural sciences, Spectral line, Geomagnetic reversal, Magnetic field, Nuclear physics, Antiproton, 0103 physical sciences, Physics::Space Physics, Physics::Accelerator Physics, Transient (oscillation), Nuclear Experiment, 010303 astronomy & astrophysics, Energy (signal processing)
Abstract

The energy spectra of cosmic-ray low-energy antiprotons and protons have been measured by BESS in 1999 and 2000, during a period covering the solar magnetic field reversal. Based on these measurements, a sudden increase of the antiproton to proton flux ratio following the solar magnetic field reversal was observed, and it generally agrees with a drift model of the solar modulation., 4 pages, 4 figures, revised version accepted for publication in Phys. Rev. Lett more...

Published
2001

60. Particle Physics Experiments at JLC

Author

Abe, Koh

Subjects
Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment, Centre for Theoretical Studies, Centre for Theoretical Studies (Ceased to exist at the end of 2003)
Abstract

ACFA Linear Collider Working Group report

Published
2001

61. Effects of smoking cessation on gastric emptying in smokers.

Author

Kadota, Koichiro, Takeshima, Fuminao, Inoue, Keita, Takamori, Ken-Ichi, Yoshioka, Sumako, Nakayama, Seiko, Abe, Koh, Mizuta, Yohei, Kohno, Shigeru, Ozono, Yoshiyuki, Kadota, Koichiro, Takeshima, Fuminao, Inoue, Keita, Takamori, Ken-Ichi, Yoshioka, Sumako, Nakayama, Seiko, Abe, Koh, Mizuta, Yohei, Kohno, Shigeru, and Ozono, Yoshiyuki more...

Abstract

BACKGROUND: Smoking cessation can lead to changes in appetite and weight gain in some patients; thus, smoking cessation may alter gastrointestinal motility. Effects of smoking cessation on gastric emptying in smokers have not been established. AIM: This study sought to determine how smoking cessation affects gastric emptying in smokers. METHODS: Participant group comprised 53 habitual smokers and 12 healthy nonsmokers. Habitual smokers were treated for 2 months with transdermal nicotine patches. Gastric emptying was studied using C acetate breath tests at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Maximal CO2 excretion time (Tmax), CO2 excretion half-life (T1/2), and parameters beta and kappa, representing initial and subsequent gastric-emptying phases, respectively, were determined using conventional formulae. RESULTS: Before smoking cessation, Tmax was reached significantly later in smokers (0.94+/-0.3 h, P=0.014) than in controls (0.89+/-0.1 h). At 1 week after the end of treatment, Tmax was significantly decreased (from 1.05+/-0.32 h to 0.72+/-0.64 h, P=0.003). T1/2 also tended to decrease, but not significantly. Although beta was decreased significantly (from 2.46+/-0.40 to 2.17+/-0.58, P=0.022), kappa was unchanged. However, by 9 weeks after the end of treatment, Tmax (1.28+/-0.69 h) had increased to levels seen before treatment. CONCLUSIONS: Smoking cessation temporarily accelerates gastric emptying, and decreases in beta suggest that initial-phase gastric emptying accelerates after smoking cessation. The temporary acceleration of gastric emptying after smoking cessation may be involved in the temporary increase in appetite and weight gain seen after smoking cessation., Journal of clinical gastroenterology, 44(4), pp.71-75; 2010 more...

Published
2010

62. Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Author

Kadota, Koichiro, Takamura, Noboru, Aoyagi, Kiyoshi, Yamasaki, Hironori, Usa, Toshiro, Nakazato, Mio, Maeda, Takahiro, Wada, Mitsuhiro, Nakashima, Ken-ichiro, Abe, Koh, Takeshima, Fuminao, Ozono, Yoshiyuki, Kadota, Koichiro, Takamura, Noboru, Aoyagi, Kiyoshi, Yamasaki, Hironori, Usa, Toshiro, Nakazato, Mio, Maeda, Takahiro, Wada, Mitsuhiro, Nakashima, Ken-ichiro, Abe, Koh, Takeshima, Fuminao, and Ozono, Yoshiyuki more...

Abstract

Background: A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial-ankle pulse wave velocity and blood pressure. Methods and Results: In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima-media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A1c and total HCY, as well as CIMT. Conclusion: CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it., Circulation Journal, 72(2), pp.304-308; 2008 more...

Published
2008

64. Risk Factors for Dysmotility, Acid Reflux Symptoms, and Overlap Using FSSG in Japan

Author

Shiota, Seiji, primary, Murakami, Kazunari, additional, Inoue, Kunimitsu, additional, Yamamoto, Kyoko, additional, Kuroda, Akiko, additional, Mizukami, Kazuhiro, additional, Okimoto, Tadayoshi, additional, Yoshiiwa, Aoi, additional, Kodama, Masaaki, additional, Abe, Koh, additional, Yamaoka, Yoshio, additional, and Fujioka, Toshio, additional more...

Published
2012
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65. Effects of Smoking Cessation on Gastric Emptying in Smokers

Author

Kadota, Koichiro, primary, Takeshima, Fuminao, additional, Inoue, Keita, additional, Takamori, Ken-ichi, additional, Yoshioka, Sumako, additional, Nakayama, Seiko, additional, Abe, Koh, additional, Mizuta, Yohei, additional, Kohno, Shigeru, additional, and Ozono, Yoshiyuki, additional more...

Published
2010
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66. Low Expression of T-cell Co-stimulatory Molecules in Bone Marrow-Derived Dendritic Cells in a Mouse Model of Chronic Respiratory Infection with Pseudomonas Aeruginosa

Author

Mukae, Hiroshi, primary, Urabe, Kanako, additional, Yanagihara, Katsunori, additional, Ishimoto, Hiroshi, additional, Sakamoto, Noriho, additional, Ishii, Hiroshi, additional, Nakayama, Seiko, additional, Ishimatsu, Yuji, additional, Abe, Koh, additional, Shirai, Ryo, additional, and Kohno, Shigeru, additional more...

Published
2010
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67. Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Author

Kadota, Koichiro, primary, Takamura, Noboru, additional, Aoyagi, Kiyoshi, additional, Yamasaki, Hironori, additional, Usa, Toshiro, additional, Nakazato, Mio, additional, Maeda, Takahiro, additional, Wada, Mitsuhiro, additional, Nakashima, Ken-ichiro, additional, Abe, Koh, additional, Takeshima, Fuminao, additional, and Ozono, Yoshiyuki, additional more...

Published
2008
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74. Analysis of inflammatory cell infiltration and its related factors in the lung of patients with diffuse panbronchiolitis.

Author

Kadota, Jun-ichi, primary, Iida, Keiko, additional, Kawakami, Kaoru, additional, Matsubara, Yuichi, additional, Shirai, Ryo, additional, Abe, Koh, additional, Taniguchi, Haruko, additional, Fujii, Takeshi, additional, Kawamoto, Sadahiro, additional, Kaseda, Makoto, additional, and Kohno, Shigeru, additional more...

Published
1997
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78. Th1‐Th2 Cytokine Kinetics in the Bronchoalveolar Lavage Fluid of Mice Infected with Cryptococcus neoformansof Different Virulences

Author

Abe, Koh, Kadota, Jun‐ichi, Ishimatsu, Yuji, Iwashita, Tetsuji, Tomono, Kazunori, Kawakami, Kazuyoshi, and Kohno, Shigeru

Abstract

Th1 immune response plays an important role in protection against infection with Cryptococcus neoformansin mice. We investigated the effect of virulence of C. neoformanson cytokine production in the lung of a mouse model of pulmonary cryptococcosis. BALB/c mice were inoculated intratracheally with a high or low virulence strain of C. neoformans, followed by serial measurements of Th1 and Th2 cytokine concentrations in the bronchoalveolar lavage (BAL) fluid using appropriate enzyme‐linked immunosorbent assay kits. The number of colony‐forming units (CFU) increased with time, and all mice infected with the highly virulent strain were dead at 28 days after inoculation. In contrast, the number of microorganisms diminished with time in the mice infected with the low virulence strain during the 4‐week study. The numbers of neutrophils and lymphocytes in the BAL fluid paralleled those of CFU. High neutrophil counts were observed in the BAL fluid of mice infected with the highly virulent strain, while lymphocyte counts were increased only in the later part of the study in mice infected with the high and low virulence strains. The concentrations of Th2 cytokine, interleukin (IL)‐4 were significantly higher in mice infected with the highly virulent strain at days 14 and 21 of infection, whereas the level of Th1 cytokine, interferon‐gamma, was significantly higher in the latter strain at days 7 and 14. Our results suggest that strain‐specific difference in the organism's ability to induce (or evade) the host immune system contributes to the outcome of infection. more...

Published
2000
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79. Measurements of primary and atmospheric cosmic-ray spectra with the BESS-TeV spectrometer

Author

Mitchell, J. W., Moiseev, A. A., Ormes, J. F., Seo, E. S., Streitmatter, R. E., Haino, Sadakazu, Sanuki, Tomoyuki, Abe, Koh, Anraku, Kazuaki, Asaoka, Yoichi, Fuke, Hideyuki, Imori, Masatoshi, Itasaki, A., Maeno, Tadashi, Makida, Yasuhiro, Matsuda, Shinya, Matsui, Nagataka, Matsumoto, Hiroshi, Nishimura, Jun, Nozaki, Mitsuaki, Orito, Shuji, Sasaki, Makoto, Shikaze, Yoshiaki, Suzuki, Junichi, Takasugi, Yoshiyuki, Tanaka, Kenichi, Tanizaki, Keisuke, Yamagami, Takamasa, Yamamoto, Akira, Yamamoto, Yasuchika, Yamato, Kazuhiro, Yoshida, Tetsuya, and Yoshimura, Koji more...

Subjects
Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, chemistry.chemical_element, Cosmic ray, Astrophysics, Atmospheric neutrino, Spectral line, Nuclear physics, Cosmic-ray helium, Nuclear Experiment, Superconducting spectrometer, Helium, Physics, Range (particle radiation), Momentum (technical analysis), Muon, Spectrometer, Astrophysics (astro-ph), High Energy Physics::Phenomenology, Atmospheric muon, chemistry, Cosmic-ray proton, High Energy Physics::Experiment, Neutrino
Abstract

著者人数: 33名, Accepted: 2004-05-04, 資料番号: SA1003540000

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80. GLD Detector Outline Document: Version 1.2

Author

Abe, Koh, Abe, Koya, Abe, Toshinori, Ando, Shinichiro, Andricek, Laci, Anraku, Kazuaki, Arogancia, Dennis C., Asakawa, Eri, Asano, Yuzo, Asaoka, Yoichi, Aso, Tsukasa, Bacala, Angelina M., Bae, Saebyok, Banerjee, Sunanda, Brau, James E., Calderini, Giovanni, Chang, Ming-Chuan, Chang, Paoti, Chang, Yuan-Hann, Checchia, Paolo, Cheon, Byung Gu, Chi, Yamkun, Chikamatsu, Takeshi, Choi, Jong Bum, Choi, Seong Youl, Choi, Youngil, Corriveau, Francois, Cremaldi, Lucien, Damerell, Chris, Delerue, Nicolas, Dixit, Madhu, Eckerlin, Guenter, Fleischer, Manfred, Fujii, Yoshiaki, Fujikawa, Tomoaki, Fujimoto, Daijiro, Fujimoto, Junpei, Fuke, Hideyuki, Gao, Yuanning, Joel Goldstein, Graf, Norman, Groot, Nicolo, Gurtu, Atul, Ha, Hyun Cheong, Haino, Sadakazu, Han, Bo Young, Hara, Kazuhiko, Hasegawa, Takuya, Gooc, Hermogenes C., Heusch, Clemens, Higuchi, Masato, Hillert, Sonja, Hioki, Zenro, Hoshina, Kotoyo, Hou, George W. S., Hsiung, Yee Bob, Huang, Chao-Shang, Huang, Hsuan-Cheng, Huang, Tao, Hwang, Pauchy W-Y, Hyun, Hyojung, Ikegami, Masahiro, Ikematsu, Katsumasa, Imhof, Andreas, Ishihara, Nobuhiro, Ishii, Koji, Ishizawa, Yoshio, Itoh, Saori, Iwasaki, Masako, Iwashita, Yoshihisa, Jackson, Dave, Jaros, John, Kah, Dongha, Kajikawa, Ryoichi, Kajino, Fumiyoshi, Kang, Joo Hwan, Kang, Joo Sang, Kanzaki, Jun-Ichi, Kato, Kiyoshi, Kato, Yukihiro, Katou, Yoshiaki, Kawabata, Setsuya, Kawagoe, Kiyotomo, Khalatyan, Norik, Khan, Sameen Ahmed, Kim, Dong Hee, Kim, Gui Nyun, Kim, Hongjoo, Kim, Shinghong, Kim, Sun Kee, Kim, Youngim, Kobayashi, Makoto, Komamiya, Sachio, Komine, Shinji, Kuang, Yu Ping, Kubo, Kiyoshi, Kumada, Masayuki, Kurashige, Hisaya, Kurihara, Yoshimasa, Kuroda, Shigeru, Kwon, Young Joon, Ky, Nguyen Anh, Lai, C. H., Ledu, Patrick, Lee, Jik, Lee, Kang Young, Li, Weiguo, Lin, Chih-Hsun, Lin, Willis T., Lin, Zhi-Hai, Luo, Minxing, Magallanes, Jingle B., Majumder, Gobinda, Maki, Akihiro, Mashimo, Tetsuro, Matsuda, Shinya, Matsuda, Takeshi, Matsui, Nagataka, Matsui, Takayuki, Matsumoto, Hiroshi, Matsumoto, Takeshi, Matsunaga, Hiroyuki, Mihara, Satoshi, Mihara, Takanori, Mikhailichenko, Alexander A., Miyamoto, Akiya, Miyata, Hitoshi, Mondal, Naba K., Moretti, Stefano, Morgunov, Vasily, Mori, Toshinori, Moser, Hans-Guenther, Nagamine, Tadashi, Nagano, Ai, Nagashima, Yorikiyo, Nakajima, Noriko, Nakamura, Isamu, Nakamura, Miwako, Nakanishi, Tsutomu, Nakano, Eiichi, Nam, Shinwoo, Namito, Yoshihito, Nauenberg, Uriel, Nishiguchi, Hajime, Nitoh, Osamu, Nozaki, Mitsuaki, Oh, Sunkun, Oh, Youngdo, Ohama, Taro, Oide, Katsunobu, Okada, Nobuchika, Okada, Yasuhiro, Okuno, Hideki, Omori, Tsunehiko, Ono, Hiroaki, Onuki, Yoshiyuki, Ootani, Wataru, Ozone, Kenji, Park, Chawon, Park, Hwanbae, Park, Il Hung, Proulx, Joseph, Reserva, Rosario L., Riles, Keith, Ronan, Mike, Saito, Kotaro, Sakai, Kazuyuki, Sanchez, Allister Levi C., Sanuki, Tomoyuki, Sekiguchi, Katsumi, Sendai, Hiroshi, Seryi, Andrei, Settles, Ron, Shang, Rencheng, Shen, Xiaoyan, Shikaze, Yoshiaki, Shioden, Masaomi, Si, Zongguo, Siddiqui, Azher M., Sirai, Miyuki, Solidum, Ruelson S., Son, Dongchul, Stoeck, Holger, Sugawara, Hirotaka, Sugimoto, Yasuhiro, Sugiyama, Akira, Sukhanov, Alexander, Suzuki, Shiro, Suzuki, Takashi, Takahashi, Tamotsu, Takahashi, Tohru, Takeda, Hiroshi, Takeda, Seishi, Takeshita, Tohru, Tamura, Norio, Tanabe, Kenji, Tani, Nobuhiro, Tauchi, Toshiaki, Teramoto, Ii Yoshiki, Thomson, Mark, Tovey, Stuart, Trimpl, Marcel, Tsuchiya, Kiyosumi, Tsukamoto, Toshifumi, Ueno, Koji, Ujiie, Norihiko, Uozumi, Satoru, Kooten, Rick J., Wang, Jian-Xiong, Wang, Minzu, Watanabe, Isamu, Watanabe, Takashi, White, Andy, Wilson, Graham W., Wing, Matthew, Won, Eunil, Yamada, Sakuei, Yamaguchi, Atsushi, Yamamoto, Hitoshi, Yamamoto, Noboru, Yamamoto, Sumie, Yamamura, Taiki, Yamaoka, Hiroshi, Yamashita, Satoru, Yamauchi, Shin, Yang, Hey Young, Yang, Jongman, Yokoya, Kaoru, Yoshida, Tetsuya, Yoshioka, Tamaki, Yu, Geumbong, Yu, Intae, Zhang, De-Hong, Zhang, Xinmin, Zhao, Zheng-Guo, and Zhu, Yong-Sheng more...

81. Particle physics experiments at JLC

Author

Abe, Koh, Abe, Koya, Abe, Toshinori, Akeroyd, Andrew G., Anraku, Kazuaki, Araya, Mamoru, Arhrib, Abdesslam, Arogancia, Dennis C., Asai, Shoji, Asakawa, Eri, Asano, Yuzo, Asaoka, Yoichi, Aso, Tsukasa, Bacala, Angelina M., Bae, Sae-Byok, Banerjee, Sunanda, Chang, Yuan-Hann, Cheung, King-Man, Chikamatsu, Takeshi, Choi, Jong Bum, Choi, Seong Yeol, Corriveau, Francois, Dobashi, Katsuhiro, Duc, Dao Vong, Endo, Ichita, Fu, Yu, Fujii, Keisuke, Fujii, Yoshiaki, Fujikawa, Motoharu, Fujimoto, Daijiro, Fujimoto, Junpei, Fuke, Hideyuki, Gao, Yuan-Ning, Ghosh, Dilip K., Godbole, Rohini M., Jiang, Yi, Jimbo, Masato, Gooc, Hermogenes C., Gurtu, Atul, Hagiwara, Kaoru, Haino, Sadakazu, Han, Bo Young, Han, Tao, Hara, Kazuhiko, Hashiguchi, Hidenori, Hayasaka, Takaya, He, Mao, Hemmi, Yasuo, Hidaka, Keisho, Higuchi, Masato, Hikasa, Ken-Ichi, Hioki, Zenro, Hirose, Tachishige, Hori, Michihiro, Hoshina, Kotoyo, Hou, George W. S., Huang, Chao-Shang, Huang, Hsuan-Cheng, Huang, Tao, Hwang, Pauchy W. Y., Ichizaki, Yohei, Ikematsu, Katsumasa, Ishida, Takuya, Ishihara, Nobuhiro, Ishihara, Satoshi, Ishizawa, Yoshio, Ito, Ikuo, Iwata, Seigi, Izumi, Kosuke, Jackson, Dave, Jagannathan, Ramaswamy, Javanmardi, Farhad, Kajikawa, Ryoichi, Kajino, Fumiyoshi, Kamoshita, Jun-Ichi, Kanemura, Shinya, Kang, Joo Hwan, Kang, Joo Sang, Kanzaki, Jun-Ichi, Kato, Kiyoshi, Kato, Yukihiro, Katou, Yoshiaki, Kawabata, Setsuya, Kawagoe, Kiyotomo, Khalatyan, Norik, Sameen Khan, Khiem, Le Hong, Kim, Choong Sun, Kim, Hong Joo, Kim, Hyun-Woo, Kim, Shing-Hong, Kim, Sun Kee, Kiyoura, Shingo, Kiyo, Yuichiro, Ko, Pyung-Won, Kobayashi, Katsuyuki, Kobayashi, Makoto, Kodaira, Jiro, Komamiya, Sachio, Komine, Shinji, Kon, Tadashi, Kuang, Yu Ping, Kubo, Kiyoshi, Kuboshima, Rie, Kumano, Satoshi, Kundu, Anirban, Kurashige, Hisaya, Kurihara, Yoshimasa, Kuroiwa, Hirotoshi, Kwon, Young Joon, Lai, C. H., Lai, Hung-Liang, Lee, Hong-Seok, Lee, Jae Sik, Lee, Jungil, Lee, Kang Young, Lee, Su Kyoung, Li, Chong-Sheng, Li, Hsiang-Nan, Li, Xue-Qian, Liao, Yi, Lin, Chih-Hsun, Lin, Willis T., Lin, Zhi-Hai, Long, Hoang Ngoc, Lu, Hong-Liang, Luo, Min-Xing, Ma, Bo-Qiang, Ma, Wen-Gan, Magallanes, Jingle B., Mashimo, Tetsuro, Masuyama, Atsuhiko, Matsuda, Shinya, Matsuda, Takeshi, Matsui, Nagataka, Matsui, Takayuki, Matsukado, Koji, Matsumoto, Hiroshi, Matsunaga, Hiroyuki, Mihara, Satoshi, Mitsuhashi, Toshiya, Miyamoto, Akiya, Miyata, Hitoshi, Mori, Toshinori, Moroi, Takeo, Morozumi, Takuya, Muto, Toshiya, Nagamine, Tadashi, Nagashima, Yorikiyo, Nakajima, Noriko, Nakamura, Isamu, Nakamura, Miwako, Nakanishi, Tsutomu, Nakano, Eiichi, Nakata, Yuichi, Namito, Yoshihito, Anh Ky, Nguyen, Nishiguchi, Hajime, Nitoh, Osamu, Nojiri, Mihoko, Nozaki, Mitsuaki, Odagiri, Kosuke, Oh, Sun-Kun, Ohama, Taro, Ohgaki, Tomomi, Oide, Katsunobu, Okada, Yasuhiro, Okuno, Hideki, Omori, Tsunehiko, Onuki, Yoshiyuki, Ootani, Wataru, Ozone, Kenji, Park, Chul-Hi, Park, Hwan-Bae, Park, Il Hung, Park, Seong Chan, Rindani, Saurabh D., Roy, Probir, Roy, Sourov, Saito, Kotaro, Sanchez, Allister Levi C., Sanuki, Tomoyuki, Sekiguchi, Katsumi, Sendai, Hiroshi, Sezaki, Tadashi, Shang, Ren-Cheng, Shen, Xiao-Yan, Shikaze, Yoshiaki, Shioden, Masaomi, Sirai, Miyuki, Solidum, Ruelson S., Song, Jeong-Hyeon, Song, H. S., Sonoda, Tomohiro, Stefanov, Konstantin, Sugimoto, Yasuhiro, Sugiyama, Akira, Sumino, Yukinari, Suzuki, Shiro, Takahashi, Shinya, Takahashi, Tamotsu, Takahashi, Tohru, Takeda, Hiroshi, Takeshita, Tohru, Tamura, Norio, Tauchi, Toshiaki, Teramoto, Yoshiki, Togawa, Kazuaki, Tong, Guo-Ling, Tovey, Stuart N., Tsuchiya, Kiyosumi, Tsukamoto, Toshifumi, Tsukamoto, Toshio, Uehara, Yosuke, Ueno, Koji, Umeda, Yoshiaki, Uozumi, Satoru, Wang, Jian-Xiong, Wan, Lang-Hui, Wang, Min-Zu, Wang, Qing, Watanabe, Isamu, Watanabe, Takashi, Won, Eu-Nil, Wu, Yue-Liang, Yamada, Youichi, Yamamoto, Hitoshi, Yamamoto, Noboru, Yamamoto, Yasuchika, Yamaoka, Hiroshi, Yamashita, Satoru, Yang, Hey Young, Yang, Jin Min, Yanga, Danilo, Yasui, Yoshinori, Yeh, G. P., Yokoya, Kaoru, Yoshida, Tetsuya, Yu, Chae-Hyn, Yu, Geum-Bong, Zhang, De-Hong, Zhang, Xin-Min, Zhang, Xue-Yao, Zhao, Zheng-Guo, Zhou, Fei, Zhou, Hong-Yi, Zhu, Shou-Hua, and Zhu, Yong-Sheng more...

82. [Two cases of pleomorphic carcinoma with severe systemic inflammation].

Author

Yoda A, Nakayama S, Abe K, Inoue K, Nakamura Y, Tagawa T, Hayashi T, Mukae H, Kohno S, and Ozono Y

Subjects
Aged, Humans, Inflammation complications, Male, Middle Aged, Carcinoma diagnosis, Lung Neoplasms diagnosis
Abstract

We report two cases of pleomorphic carcinoma with fever and severe inflammatory reaction. In case 1, an abnormal mass shadow was found on the chest X-ray film of a 63-year-old man with bloody sputum. After right upper lobectomy, the tumor was diagnosed as pleomorphic carcinoma. About 7 months after surgical operation, he had fever and chest pain. Although his test results showed leukocytosis and his elevated serum CRP level indicated some infection, there were no signs of bacterial or fungal infection. Further examination revealed metases of lung cancer in the left adrenal gland, mediastinal and iliac lymph nodes. Serological study revealed elevated level of G-CSF, likely due to G-CSF producing metastatic tumors. In case 2, a 77-year-old man presented with continuous high fever. Examinations revealed elevated serum CRP level and multiple nodular shadows and enlarged supraclavicular and mediastinal lymph nodes on the chest CT, suggesting some infectious, connective tissue, or lymphoproliferative diseases. He was finally found to have pleomorphic carcinoma of the lung by histological examination of lymph nodes. The continuous high fever seemed to be a tumor-related fever, because it rapidly disappeared after administration of naproxen. more...

Published
2009

83. [Case of nonspecific interstitial pneumonia associated with aortitis syndrome].

Author

Sakamoto N, Mukae H, Ishii H, Nakayama S, Kakugawa T, Yoshioka S, Urabe K, Abe K, Hayashi T, and Kohno S

Subjects
Adult, Female, Hemorrhage etiology, Humans, Lung Diseases etiology, Lung Diseases, Interstitial pathology, Pulmonary Alveoli, Lung Diseases, Interstitial etiology, Takayasu Arteritis complications
Abstract

A 32-year-old woman was admitted to our hospital because of fever and back pain. Two months previously, she had been given a diagnosis of bacterial pneumonia based on the same symptoms and recovered after antibiotic treatment. Chest CT scans on admission showed a consolidation and thickened pleura in the right lower lobe. Bronchoalveolar lavage fluids showed an alveolar hemorrhage. Lung biopsy specimens showed thickened pulmonary arteries and fibrotic nonspecific interstitial pneumonia (NSIP). Three years later, she was admitted with fever and pain of the left arm and aortitis syndrome was diagnosed. In this case of NSIP pattern associated with aortitis syndrome we speculate that repeated pulmonary infarction and alveolar hemorrhages caused the NSIP pattern. more...

Published
2008

84. Elevated serum beta-defensins concentrations in patients with lung cancer.

Author

Arimura Y, Ashitani J, Yanagi S, Tokojima M, Abe K, Mukae H, and Nakazato M

Subjects
Aged, Carcinoma, Non-Small-Cell Lung blood, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Small Cell blood, Carcinoma, Small Cell pathology, Female, Humans, Immunohistochemistry, Lung Neoplasms pathology, Male, Neoplasm Staging, Biomarkers, Tumor blood, Lung Neoplasms blood, beta-Defensins blood
Abstract

Background: Beta-defensins (HBDs) are expressed in lung epithelial cells and act as antimicrobial agents. Most lung cancers that originate from pulmonary epithelial cells may produce HBDs., Materials and Methods: We measured serum HBD-1 and HBD-2 levels in healthy subjects (HS), patients with lung cancer and patients with pneumonia by radioimmunoassay., Results: Serum HBD-1 levels were higher in patients with lung cancer than HS and patients with pneumonia. Serum HBD-2 levels were higher in patients with lung cancer than HS. When cut-off values for positive HBD-1 were set at mean + 2SD of HS, the sensitivity and specificity of HBD-1 for the whole group of patients with lung cancer were 76.4 and 94.0%, respectively, and the proportion of patients with HBD-1-positive lung cancer and clinical stage I was 69.2%., Conclusion: Serum HBDs levels were high in patients with lung cancer and the serum HBD-1 level could be used as an auxiliary diagnostic tool for lung cancer. more...

Published
2004

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