Search

Your search keyword '"ARORA, AMIT"' showing total 1,915 results
Start Over Author "ARORA, AMIT"
1,915 results on '"ARORA, AMIT"'

53. Introduction

Author

McIntyre, John R., Arora, Anshu Saxena, Arora, Amit, Saxena Arora, Anshu, Series Editor, Arora, Anshu Saxena, editor, Jentjens, Sabine, editor, Arora, Amit, editor, McIntyre, John R., editor, and Sepehri, Mohamad, editor

Published
2022
Full Text
View/download PDF

68. Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension

Author

Karnes, Jason H, Wiener, Howard W, Schwantes-An, Tae-Hwi, Natarajan, Balaji, Sweatt, Andrew J, Chaturvedi, Abhishek, Arora, Amit, Batai, Ken, Nair, Vineet, Steiner, Heidi E, Giles, Jason B, Yu, Jeffrey, Hosseini, Maryam, Pauciulo, Michael W, Lutz, Katie A, Coleman, Anna W, Feldman, Jeremy, Vanderpool, Rebecca, Tang, Haiyang, Garcia, Joe GN, Yuan, Jason X-J, Kittles, Rick, de Jesus Perez, Vinicio, Zamanian, Roham T, Rischard, Franz, Tiwari, Hemant K, Nichols, William C, Benza, Raymond L, and Desai, Ankit A

Subjects
Lung, Good Health and Well Being, Adult, Black or African American, Aged, Female, Hispanic or Latino, Humans, Male, Middle Aged, Pulmonary Arterial Hypertension, Survival Rate, United States, White People, pulmonary arterial hypertension, Hispanic American, Native American, survival, health disparities, Medical and Health Sciences, Respiratory System
Abstract

Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries with genome-wide data and two local cohorts, and further incorporated in a global meta-analysis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for transplant-free, all-cause mortality in Hispanic patients with non-Hispanic white (NHW) patients as the reference group. Odds ratios (ORs) for inpatient-specific mortality in patients with PAH were also calculated for race/ethnic groups from an additional National Inpatient Sample dataset not included in the meta-analysis.Measurements and Main Results: After covariate adjustment, self-reported Hispanic patients (n = 290) exhibited significantly reduced mortality versus NHW patients (n = 1,970) after global meta-analysis (HR, 0.60 [95% CI, 0.41-0.87]; P = 0.008). Although not significant, increasing Native American genetic ancestry appeared to account for part of the observed mortality benefit (HR, 0.48 [95% CI, 0.23-1.01]; P = 0.053) in the two national registries. Finally, in the National Inpatient Sample, an inpatient mortality benefit was also observed for Hispanic patients (n = 1,524) versus NHW patients (n = 8,829; OR, 0.65 [95% CI, 0.50-0.84]; P = 0.001). An inpatient mortality benefit was observed for Native American patients (n = 185; OR, 0.38 [95% CI, 0.15-0.93]; P = 0.034).Conclusions: This study demonstrates a reproducible survival benefit for Hispanic patients with Group 1 PAH in multiple clinical settings. Our results implicate contributions of genetic ancestry to differential survival in PAH.

Published
2020

69. Performance Evaluation of Enhancement Algorithm for Contrast Distorted Images

Author

Rekhi, Navleen S., Singh, Jasjit, Sidhu, Jagroop S., Arora, Amit, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Kaiser, M. Shamim, editor, Bandyopadhyay, Anirban, editor, Ray, Kanad, editor, Singh, Raghvendra, editor, and Nagar, Vishal, editor

Published
2022
Full Text
View/download PDF

70. Cross-stream Deployment of Delta Vortex Generators in Finned Tube Arrays for Flow Modification and Capacity Augmentation

Author

Arora, Amit, Subbarao, P. M. V., Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Maiti, D. K., editor, Jana, P., editor, Mistry, C. S., editor, Ghoshal, R., editor, Afzal, M. S., editor, Patra, P. K., editor, and Maity, D., editor

Published
2022
Full Text
View/download PDF

71. Stream-wise Deployment of Vortex Generators in Finned Tube Arrays for Capacity Enhancement Through Flow Modification

Author

Arora, Amit, Subbarao, P. M. V., Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Maiti, D. K., editor, Jana, P., editor, Mistry, C. S., editor, Ghoshal, R., editor, Afzal, M. S., editor, Patra, P. K., editor, and Maity, D., editor

Published
2022
Full Text
View/download PDF

75. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author

Burstein, Roy, Henry, Nathaniel J, Collison, Michael L, Marczak, Laurie B, Sligar, Amber, Watson, Stefanie, Marquez, Neal, Abbasalizad-Farhangi, Mahdieh, Abbasi, Masoumeh, Abd-Allah, Foad, Abdoli, Amir, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abrigo, Michael RM, Acharya, Dilaram, Adebayo, Oladimeji M, Adekanmbi, Victor, Adham, Davoud, Afshari, Mahdi, Aghaali, Mohammad, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadpour, Ehsan, Ahmed, Rushdia, Akal, Chalachew Genet, Akinyemi, Joshua O, Alahdab, Fares, Alam, Noore, Alamene, Genet Melak, Alene, Kefyalew Addis, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Aljunid, Syed Mohamed, Almalki, Mohammed J, Al-Mekhlafi, Hesham M, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amegah, Adeladza Kofi, Amini, Saeed, Amit, Arianna Maever Loreche, Anbari, Zohreh, Androudi, Sofia, Anjomshoa, Mina, Ansari, Fereshteh, Antonio, Carl Abelardo T, Arabloo, Jalal, Arefi, Zohreh, Aremu, Olatunde, Armoon, Bahram, Arora, Amit, Artaman, Al, Asadi, Anvar, Asadi-Aliabadi, Mehran, Ashraf-Ganjouei, Amir, Assadi, Reza, Ataeinia, Bahar, Atre, Sachin R, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Azari, Samad, Babaee, Ebrahim, Babazadeh, Arefeh, Badawi, Alaa, Bagheri, Soghra, Bagherzadeh, Mojtaba, Baheiraei, Nafiseh, Balouchi, Abbas, Barac, Aleksandra, Bassat, Quique, Baune, Bernhard T, Bayati, Mohsen, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Belay, Yared Belete, Bell, Brent, Bell, Michelle L, Berbada, Dessalegn Ajema, Bernstein, Robert S, Bhattacharjee, Natalia V, Bhattarai, Suraj, Bhutta, Zulfiqar A, Bijani, Ali, Bohlouli, Somayeh, Breitborde, Nicholas JK, Britton, Gabrielle, Browne, Annie J, Nagaraja, Sharath Burugina, Busse, Reinhard, Butt, Zahid A, Car, Josip, Cárdenas, Rosario, Castañeda-Orjuela, Carlos A, Cerin, Ester, Chanie, Wagaye Fentahun, Chatterjee, Pranab, and Chu, Dinh-Toi

Subjects
Pediatric, Pediatric Research Initiative, Prevention, Infant Mortality, 2.4 Surveillance and distribution, Aetiology, Good Health and Well Being, Reduced Inequalities, Child, Child Mortality, Geography, Global Health, Humans, Infant, Infant, Newborn, Organizational Objectives, Public Health, Socioeconomic Factors, United Nations, General Science & Technology
Abstract

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000-2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations.

Published
2019

100. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

Author

Rhodes, Christopher J, Batai, Ken, Bleda, Marta, Haimel, Matthias, Southgate, Laura, Germain, Marine, Pauciulo, Michael W, Hadinnapola, Charaka, Aman, Jurjan, Girerd, Barbara, Arora, Amit, Knight, Jo, Hanscombe, Ken B, Karnes, Jason H, Kaakinen, Marika, Gall, Henning, Ulrich, Anna, Harbaum, Lars, Cebola, Inês, Ferrer, Jorge, Lutz, Katie, Swietlik, Emilia M, Ahmad, Ferhaan, Amouyel, Philippe, Archer, Stephen L, Argula, Rahul, Austin, Eric D, Badesch, David, Bakshi, Sahil, Barnett, Christopher, Benza, Raymond, Bhatt, Nitin, Bogaard, Harm J, Burger, Charles D, Chakinala, Murali, Church, Colin, Coghlan, John G, Condliffe, Robin, Corris, Paul A, Danesino, Cesare, Debette, Stéphanie, Elliott, C Gregory, Elwing, Jean, Eyries, Melanie, Fortin, Terry, Franke, Andre, Frantz, Robert P, Frost, Adaani, Garcia, Joe GN, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J Simon R, Harley, John, He, Hua, Hill, Nicholas S, Hirsch, Russel, Houweling, Arjan C, Howard, Luke S, Ivy, Dunbar, Kiely, David G, Klinger, James, Kovacs, Gabor, Lahm, Tim, Laudes, Matthias, Machado, Rajiv D, Ross, Robert V MacKenzie, Marsolo, Keith, Martin, Lisa J, Moledina, Shahin, Montani, David, Nathan, Steven D, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Oudiz, Ronald J, Ouwehand, Willem H, Peacock, Andrew J, Pepke-Zaba, Joanna, Rehman, Zia, Robbins, Ivan, Roden, Dan M, Rosenzweig, Erika B, Saydain, Ghulam, Scelsi, Laura, Schilz, Robert, Seeger, Werner, Shaffer, Christian M, Simms, Robert W, Simon, Marc, Sitbon, Olivier, Suntharalingam, Jay, Tang, Haiyang, Tchourbanov, Alexander Y, Thenappan, Thenappan, Torres, Fernando, Toshner, Mark R, Treacy, Carmen M, Noordegraaf, Anton Vonk, Waisfisz, Quinten, and Walsworth, Anna K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Genetics, Human Genome, Lung, Aetiology, 2.1 Biological and endogenous factors, Cardiovascular, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotyping Techniques, HLA-DP alpha-Chains, HLA-DP beta-Chains, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Pulmonary Arterial Hypertension, Risk Assessment, SOXF Transcription Factors, Signal Transduction, Survival Analysis, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Public Health and Health Services, Other Medical and Health Sciences, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundRare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.MethodsWe did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension. These GWAS used data from four international case-control studies across 11 744 individuals with European ancestry (including 2085 patients). One GWAS used genotypes from 5895 whole-genome sequences and the other GWAS used genotyping array data from an additional 5849 individuals. Cross-validation of loci reaching genome-wide significance was sought by meta-analysis. Conditional analysis corrected for the most significant variants at each locus was used to resolve signals for multiple associations. We functionally annotated associated variants and tested associations with duration of survival. All-cause mortality was the primary endpoint in survival analyses.FindingsA locus near SOX17 (rs10103692, odds ratio 1·80 [95% CI 1·55-2·08], p=5·13 × 10-15) and a second locus in HLA-DPA1 and HLA-DPB1 (collectively referred to as HLA-DPA1/DPB1 here; rs2856830, 1·56 [1·42-1·71], p=7·65 × 10-20) within the class II MHC region were associated with pulmonary arterial hypertension. The SOX17 locus had two independent signals associated with pulmonary arterial hypertension (rs13266183, 1·36 [1·25-1·48], p=1·69 × 10-12; and rs10103692). Functional and epigenomic data indicate that the risk variants near SOX17 alter gene regulation via an enhancer active in endothelial cells. Pulmonary arterial hypertension risk variants determined haplotype-specific enhancer activity, and CRISPR-mediated inhibition of the enhancer reduced SOX17 expression. The HLA-DPA1/DPB1 rs2856830 genotype was strongly associated with survival. Median survival from diagnosis in patients with pulmonary arterial hypertension with the C/C homozygous genotype was double (13·50 years [95% CI 12·07 to >13·50]) that of those with the T/T genotype (6·97 years [6·02-8·05]), despite similar baseline disease severity.InterpretationThis is the first study to report that common genetic variation at loci in an enhancer near SOX17 and in HLA-DPA1/DPB1 is associated with pulmonary arterial hypertension. Impairment of SOX17 function might be more common in pulmonary arterial hypertension than suggested by rare mutations in SOX17. Further studies are needed to confirm the association between HLA typing or rs2856830 genotyping and survival, and to determine whether HLA typing or rs2856830 genotyping improves risk stratification in clinical practice or trials.FundingUK NIHR, BHF, UK MRC, Dinosaur Trust, NIH/NHLBI, ERS, EMBO, Wellcome Trust, EU, AHA, ACClinPharm, Netherlands CVRI, Dutch Heart Foundation, Dutch Federation of UMC, Netherlands OHRD and RNAS, German DFG, German BMBF, APH Paris, INSERM, Université Paris-Sud, and French ANR.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results