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We explored the relationships between resistance exercise volume/intensity and muscle myofibrillar protein synthetic (MPS) responses in young and older men. In a crossover design, four groups of six young (24±6 years) and older (70±5 years) men performed two volumes of resistance exercise: either 40% one repetition maximum (1RM) (3 × 14, then 6 × 14 repetitions) or 75% 1RM (3 × 8, then 6 × 8 repetitions), such that at the same volume, work was identical between intensities. Muscle biopsies were taken 0, 1, 2, and 4hours after exercise to measure MPS via myofibrillar bound [1,2-13C2]leucine and indices of mammalian target of rapamycin signaling by immunoblotting. In younger men, doubling exercise volume produced limited added effects, whereas in older men, it resulted in greater MPS and p70S6 kinase (p70S6KThr389) phosphorylation at both intensities, that is, MPS area under the curve: 75% (1× volume: 0.07±0.01 vs 2× volume: 0.14% ± 0.02% protein synthesized/4hours (p < .001). Doubling exercise volume is a valid strategy to maximize postexercise MPS in ageing. [ABSTRACT FROM PUBLISHER]

Background: Intake of monounsaturated fatty acids has been reported to reduce oxidative stress, insulin resistance and related inflammatory processes and may thus protect from skin photoaging. The objective of this study was to investigate the association between the risk of photoaging, monounsaturated fatty acids intake and the sources of monounsaturated fatty acids. Methodology/Principal Findings: A cross sectional study was conducted within the framework of the SUVIMAX cohort. The survey included 1264 women and 1655 men aged between 45 and 60 years old. Dietary monounsaturated fatty acids intakes were estimated by dietary source through at least ten 24-h diet records completed during the first 2.5 years of the follow-up period. Trained investigators at baseline graded severity of facial skin photoaging during a clinical examination using a 6-grade scale illustrated by photographs. A lower risk of severe photoaging was associated with higher intakes of monounsaturated fatty acids from olive oil in both sexes. Strikingly, no association was found with intake of monounsaturated fatty acids from animal sources whether from dairy products, meat or processed meat. Conclusion/Significance: These findings support the beneficial effect of dietary olive oil or healthy diet habits associated with olive oil consumption on the severity of facial photoaging. [ABSTRACT FROM AUTHOR]

Governments around the developed world are seeking to meet the challenges of the ageing population through strategies which promote a holistic approach to ageing, captured in catch-phrases such as ‘successful’, ‘active’, ‘positive’ and ‘healthy’ ageing. These strategies are supported by a growing body of research, with a particular emphasis on the prerequisites for health and quality of life. Drawing on that research, and using a methodology developed by the London School of Hygiene and Tropical Medicine, the ‘Minimum Income for Healthy Living (MIHL): Older New Zealanders’ study used a health lens to investigate the retirement income needs of older New Zealanders living independently in the community. The MIHL was estimated for people living alone, couples, renters and debt-free home owners. In each case, the MIHL estimates were appreciably higher than the universal state pension paid to older New Zealanders. People living alone and those renting their homes were shown to be worse off than couples and debt-free home owners, respectively. The results highlight that many older New Zealanders are living on an income which may not be enough to support a healthy life. This has important implications for the demand for health, residential and social services and brings life to the question of what level of income might be needed in retirement. [ABSTRACT FROM PUBLISHER]

Hyponutrition is a common problem at all health care levels, from primary to specialized care, as well as in geriatric care. Its incidence in a hospital setting is 40% and 60% in nursing homes. This is very important, it is highly related with progressive aging of the European population, and is the biggest and most frequent cause of disability among the elderly population living at home or institutions. Countries such as Holland, Denmark, or the United Kingdom have developed Comprehensive Strategic Plans to fight against hyponutrition by developing and implementing guidelines, establishing mandatory screenings at the moment of hospital admission and discharge, at nursing homes, etc. In our country, a combined action of SENPE and Abbott Foundation is developing a Comprehensive Strategic Plan (+ nutridos Project) in which clear, precise, and validated recommendations are established to perform nutritional screening both in hospitalized patients and institutionalized and ambulatory elderly people. This issue has to take into account the social and financial aspects. Hyponutrition is many times insufficiently recognized and treated. This has a negative impact on the individual patient in terms of morbidity, mortality, independence, and quality of life, as well as on the health care systems in terms of use of health care resources and costs. [ABSTRACT FROM AUTHOR]

Underlying the importance of research on the biology of aging is the fact that many nations face the demographic reality of a rapidly aging populace and the looming healthcare challenges that it brings. This reality is a result of aging itself being the most significant risk factor for a range of the most prevalent diseases, including many cancers, cardiovascular disease, and diabetes. Accordingly, interventions are sorely needed that would be able to delay or prevent diseases and disorders associated with the aging process and thereby increase the period of time that aging individuals are in good health (the health-span). Caloric restriction (CR) has emerged as a model of major interest as it is widely agreed that CR is the most potent environmental intervention that delays the onset of aging and extends life span in diverse experimental organisms. A better understanding of the mechanisms by which CR delays aging will reveal new insights into the aging process and the underlying causes of disease vulnerability with age. These novel insights will allow the development of novel treatments and preventive measures for age-associated diseases and disorders. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Introduction: Elderly subjects are considered a vulnerable group and they have more risk of nutritional problems. The risk of malnutrition increases in hospitalized geriatric patients. Objectives: To compare the correlation between MNA and GNRI with anthropometric, biochemical and Barthel Index in hospitalized geriatric patients and to test the concordance between MNA and GNRI and between Mini Nutritional Assessment Short Form (MNA-SF) and MNA. Methods: It was a cross-sectional study on a sample of 40 hospitalized geriatric patients. For determination nutritional status we used MNA and GNRI; we evaluated the correlation between this both test with biochemical and anthropometric parameters and functional questionnaires. We used Pearson's simple correlation model, one-way ANOVA and multiple logistic regression to evaluate the relationship between MNA and GNRI. Results: According to MNA, 17 patients (42.5%) were malnourished and according to GNRI, 13 patients (32.5%) had high risk of nutritional complications. The concordance of MNA and GNRI was 39% and between MNA-SF and MNA was 81%. The most significant differences were detected in weight, BMI, arm and calf circumference and weight loss parameters. Barthel index was significantly different in both tests. The MNA and GRNI had significant correlations with albumin, total protein, transferring, arm and calf circumference, weight loss and BMI parameters. Conclusions: In conclusion, it would be reasonable to use GRNI in cases where MNA is not applicable, or even use GRNI as a complement to MNA in hospitalized elderly patients. There is no reason why they should be deemed incompatible, and patients could benefit from more effective nutritional intervention. [ABSTRACT FROM AUTHOR]

Rodents are often the species of choice to examine the effect of drugs on survival and on the progression of specific diseased tissues. This statement is also true for research laboratories working in the field of nutrition and aging. In addition to diets that can reduce the life expectancy of rodents, such as diabetogenic or high-fat diets, genetically modified rodents exhibiting different accelerated age-associated diseases also provide important biologic tools to decipher the impact of drugs, nutrients, or phytoactive compounds on their health and life span. This review covers some of the chemicals believed to decelerate the appearance of age-related diseases in different rodent models. Such chemicals include antioxidants, anti-inflammatory molecules, modulators of metabolic sensors, calorie restriction mimetics, and vegetal polyphenolic compounds that affect mitochondrial functions, cellular proliferation or differentiation as well as cell functionality. [ABSTRACT FROM AUTHOR]

Background: Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood. Objective: We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress. Design: Eight elderly and 8 younger subjects received stable-isotope infusions of [2H2]glycine, after which red blood cell (RBC) glutathione synthesis and concentrations, plasma oxidative stress, and markers of oxidant damage (eg, F2-isoprostanes) were measured. Elderly subjects were restudied after 2 wk of glutathione precursor supplementation. Results: Compared with younger control subjects, elderly subjects had markedly lower RBC concentrations of glycine (486.7 ° 28.3 compared with 218.0 ° 23.7 μmol/L; P < 0.01), cysteine (26.2 ° 1.4 compared with 19.8 ° 1.3 μmol/L; P < 0.05), and glutathione (2.08 ° 0.12 compared with 1.12 ° 0.18 mmol/L RBCs; P < 0.05); lower glutathione fractional (83.14 ° 6.43% compared with 45.80 ° 5.69%/d; P < 0.01) and absolute (1.73 ° 0.16 compared with 0.55 ° 0.12 mmol/L RBCs per day; P < 0.01) synthesis rates; and higher plasma oxidative stress (304 ° 16 compared with 346 ° 20 Carratelli units; P < 0.05) and plasma F2-isoprostanes (97.7 ° 8.3 compared with 136.3 ° 11.3 pg/mL; P < 0.05). Precursor supplementation in elderly subjects led to a 94.6% higher glutathione concentration, a 78.8% higher fractional synthesis rate, a 230.9% higher absolute synthesis rate, and significantly lower plasma oxidative stress and F2-isoprostanes. No differences in these measures were observed between younger subjects and supplemented elderly subjects. Conclusions: Glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis. Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. These findings suggest a practical and effective approach to decreasing oxidative stress in aging. [ABSTRACT FROM AUTHOR]

Abstract: It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific nutrient. The problem is complex because is it difficult to measure what a fly actually consumes. A powerful solution uses the geometric framework of nutrition where diets in many combinations can be tested for their effects on lifespan and reproduction while measuring intake. Applied to Drosophila, it is now clear that specific nutrients, not calories, mediate longevity. The geometric framework also reveals a nutritional basis for the trade-off between reproduction and lifespan. This complements a stable-isotope analysis that tracked the allocation of nitrogen, carbon and essential amino acids into eggs versus reproduction. Together, these studies show that it is not possible to explain how DR extends lifespan through a mechanism were resources are simply reallocated to somatic maintenance away from reproduction. Although promising in principle, genetic analysis of DR mechanisms has had limited success. To be productive, studies must include enough diets at appropriate concentrations. In reviewing the best data, there is little evidence to date for any gene to be required for DR to increase Drosophila lifespan, including insulin signaling or 4eBP. Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework. [Copyright &y& Elsevier]

Projected growth in the older population suggests an increasing demand for supportive services. Older adults' preferences combined with limited private and public resources indicate that aging in place may be the best means for meeting the needs of an aging population. This article describes the need for options that promote aging in place as a viable choice. The authors use an ecosystem approach to providing interventions, including home modifications, nutritional interventions, innovative clothing, and care organization and management that would enhance successful aging in place. [ABSTRACT FROM AUTHOR]

The purpose of this study was to extend earlier research on the dining assistant (DA) federal regulation allowing trained non-nursing staff to provide feeding assistance care in nursing homes. Observations were conducted pre- and post-implementation, with periodic observations during implementation. To assess sustainability, data were analyzed at 12 months post-implementation. Results replicated previous findings: DAs spent more time assisting residents, and the quality of care was comparable to that of nurse aides. Results confirmed continuation of the program at 12 months post-implementation. DA programs that augment nursing home staffing levels offer a feasible way to improve feeding assistance care within the constraints of existing resources. INSET: KEYPOINTS. [ABSTRACT FROM AUTHOR]

Background: The purpose of this study was to compare the relationship between body fat percent utilizing Bod Pod (BF%) and body mass index (BMI) in premenopausal, perimenopausal, and postmenopausal women between the ages of 18-71 years. Methods: BF%, BMI, bioelectrical impedance, waist-to-hip, waist circumference, and activity level were assessed for a total of 252 female participants (106 premenopausal, 64 perimenopausal, and 82 postmenopausal women). BMI cut-points used to characterize overweight and obese were 25 kg/m2 and 30 kg/m2, respectively and 30% and 35%, respectively to define overweight and obesity by BF%. Using BF%, receiver operator characteristic (ROC) curves established optimal BMI cut-points. Physical activity levels were scored as inactive, minimally active, or active. Results: BF% significantly increased (P<0.05) from premenopausal (35.10±8.35%) to perimenopausal (39.20±8.62%) to postmenopausal (43.49±8.51%) although there was no significant change in BMI from premenopausal (25.73±5.86 kg/m2) to perimenopausal (26.32±6.41 kg/m2) to postmenopausal (27.61±6.10 kg/m2). For overweight (BF% ⩾ 30) using BMI ⩾ 25 kg/m2 and obese (BF% ⩾ 35) using BMI ⩾ 30 kg/m2 the best sensitivity and specificity was seen when cut-points were reduced to 23 kg/m2 for overweight and 24 kg/m2 for obesity. Premenopausal women were significantly (P < 0.05) less fat than perimenopausal and postmenopausal women. Perimenopausal women were also significantly (P < 0.05) less fat than postmenopausal women. Participants who were inactive were significantly (P < 0.05) fatter than participants who were minimally active and active. Conclusion: Although females are not gaining significant weight in their lifetime, they increase body fat from premenopausal to postmenopausal. [ABSTRACT FROM AUTHOR]

The article focuses on the importance of research and development concerning the nutrition and wellness needs of older people in California. It says that quality-of-life approaches and perceived benefits from physical activity and improved diet, nutrition, and fitness can contribute to healthy aging. It mentions several factors that increase the risk of disease associated with aging including physiological changes, socioeconomic factors, and food security.

Abstract: Objectives: To investigate the effects of a nutritional intervention on the body weight, body composition, blood glucose and lipid levels of obese postmenopausal women taking atypical antipsychotics in Greece. Study design: In a case–control design, 25 obese postmenopausal women treated with antipsychotic medications and 28 obese healthy comparisons were followed for 3 months. A nutritional program was individually designed for each participant. Main outcome measures: At baseline and at 3 months of the study, anthropometric, body composition, blood glucose and lipid measurements were performed. Results: Significant reductions in body weight, body mass index (BMI), fat and waist circumference were found both in the patients and their healthy comparisons from baseline to 3 months (P <0.05). Patients reduced significantly less their BMI (P =0.044) and body fat percentage compared to the healthy women (P =0.023). Waist circumference was significantly reduced in both subject groups, with no significant difference found between them (P =0.07). Glucose and lipid levels were not altered during the intervention in the patients’ group, while significant changes were observed in the healthy women in total cholesterol (P =0.016), low density lipoprotein cholesterol (P =0.022) and triglycerides (P =0.042). Conclusions: Obese postmenopausal women on atypical antipsychotic medication appear to respond favorably to a nutritional program. The improvements seen in BMI and body fat are attenuated in the patients compared to their healthy counterparts; moreover no change in lipid levels was found in the patients’ group. These findings suggest that atypical antipsychotics may play an adverse role in fat loss and lipid metabolism in this population. [Copyright &y& Elsevier]

Objective: Vitamin D has been shown to have multiple biological targets mediated by the vitamin D receptor present in many cells. Specific actions on the central nervous system (CNS) have been described. The objective of this review was to describe the relationship between vitamin D and the nervous system throughout the different stages of life. Methods: A bibliographical search was performed in the MedLine and Cochrane library databases. The keywords used were: ‘vitamin D’ and ‘nervous system’ and/or ‘central nervous system’ and/or ‘nervous system diseases’ and/or ‘psychological tests’ and/or ‘neuropsychological tests’ and/or ‘mental disorders’. The search period ranged from 01/01/1988 to 31/10/2009. Two hundred and ninety-five abstracts were first identified after screening. A final selection of 127 articles was used for the purpose of this review. Results: The studies published over the past 20 years provide an increasing number of arguments in favor of a life-long role of vitamin D on the nervous system as a whole, and in particular on the CNS. During cerebral development, vitamin D may act like a neurosteroid hormone in the areas of neurotransmission, neuroprotection, and neuroimmunomodulation. Moreover, vitamin D deficiency has been associated with neurological and psychiatric disorders. In older adults, hypovitaminosis D has been associated with neuromuscular disorders, dementia, and Parkinson’s disease. Thus, vitamin D supplementation might have a protective effect against these neurological disorders. Conclusions: Vitamin D has been associated with many neurological functions and its deficiency with dysfunction. Low serum 25-hydroxyvitamin D concentrations can potentially be reversed. This simple and low-cost correction might contribute to the primo-secondary prevention of various neuropsychiatric disorders. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Human senescence marker protein 30 (SMP30), which functions enzymatically as a lactonase, hydrolyzes various carbohydrate lactones. The penultimate step in vitamin-C biosynthesis is catalyzed by this enzyme in nonprimate mammals. It has also been implicated as an organophosphate hydrolase, with the ability to hydrolyze diisopropyl phosphofluoridate and other nerve agents. SM P30 was originally identified as an aging marker protein. whose expression decreased androgen independently in aging cells. SMP30 is also referred to as regucalcin and has been suggested to have functions in calcium homeostasis. The crystal structure of the human enzyme has been solved from X-ray diffraction data collected to a resolution of 1.4 A. The protein has a 6-bladed β-propeller fold, and it contains a single metal ion. Crystal structures have been solved with the metal site bound with eithera Ca2+ or a Zn2+ atom. Thecatalytic role of the metal ion has been confirmed by mutagenesis of the metal coordinating residues. Kinetic studies using the substrate gluconolactone showed a keat preference of divalent cations in the order Zn2+ > Mn2+ > Ca2+ > Mg2+. Notably, the Ca2+ had a significantly higher value of K compared to those of the other metal ions tested (566, 82, 7, and 0.6 μm for Ca2+ Mg2+ Zn2+ and Mn2+ respectively), suggesting that the Cat-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. [ABSTRACT FROM AUTHOR]

Abstract: The aim of the present work was to verify whether extra-virgin olive oil, a food naturally containing phenolic antioxidants, has the potential to protect from the pro-aging effects of a high-calorie diet. Male rats were fed from age 12 months to senescence a high-calorie diet containing either corn oil (CO), or extra-virgin olive oil with high (H-EVOO) or low (L-EVOO) amounts of phenols. The prolonged high fat intake led to obesity, liver lipid degeneration and insulin resistance, which were not counteracted by high phenol intake. No difference in overall survival was found at the end of the experiment in the animals treated with H-EVOO compared to the other groups. However, we did detect a protective effect of olive oil on some age-related pathologies and on blood pressure, of which the former was associated with the antioxidant content. Concomitantly, a decrease in DNA oxidative damage in blood cells and plasma TBARS and an increase in liver superoxide dismutase were detected following H-EVOO consumption. Thus, although olive oil phenols cannot reverse the detrimental effects of a prolonged intake of high amounts of fat, improving the quality of olive oil in terms of antioxidant content can be beneficial. [Copyright &y& Elsevier]

The article offers information on the aging workforce in the U.S. Topic highlights the negative effects of aging to employees including declination of muscle strength, loss of light transmissivity, body pain, diminution of neurological sensitivity and reduction of maximum oxygen intake. Also discussed is the importance of ergonomics for the productivity and safety improvement of older workers.

Botanicals have numerous health benefits. Here, we used the Mexican fruit fly to screen 14 compounds and botanicals for their prolongevity effects and found an oregano and cranberry mixture (OC) improved survival. We then evaluated prolongevity effects of OC within the context of diet composition. Individual flies were fed 0%, 1%, or 2% OC in one of the three diets containing sugar and yeast extract (SY) at a ratio of 3:1, 9:1, or 24:1. We found that prolongevity effects of OC depended upon dose, gender, and diet composition. The greatest increase in longevity was observed in females fed the SY24:1 diet with 2% OC compared to the non-supplemented diet. OC did not reduce egg laying and, hence, did not compromise fecundity under any dietary condition tested here. This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender. [ABSTRACT FROM PUBLISHER]

Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed. [ABSTRACT FROM AUTHOR]

Abstract: This paper is one in a series of experimental studies on the effects of food composition on aging and longevity, using the golden-haired blowfly Calliphora stygia as the animal model. Here we examine how diet fat content affects blowfly life history traits such as longevity, reproduction, feeding rate, body mass, total fat content and membrane fatty acid composition. The highest median and maximum longevity was observed in blowflies fed on low fat diets, while high-fat diets caused more rapid death of the blowflies. A major result was that blowflies feeding on the lowest fat diet had the highest maximal lifespan demonstrating that low levels of diet fat enhanced blowfly lifespan. Diet also influenced gender-specific mortality rates; females lived longer on a high-fat diet, while males lived longer on a low fat diet. Furthermore, we provide data for and explain how blowfly feeding rates, egg production and male harassment affected blowfly longevity. Our results highlight the need for further studies to understand how dietary fats are metabolised and utilised in the golden-haired blowfly. [Copyright &y& Elsevier]

The article provides an update on "Nutrition and the Variation in Level and Age Patterns of Mortality," by Timothy B. Gage and Kathleen O'Connor, published in 1994. The paper aims to exhibit the statistical association of nutritional level and dietary components on the overall mortality level and age patterns of mortality. The demographic literature has focused on stature as an indicator of nutritional status. Several patterns in mortality and aging have been identified by the field of biodemography.

Abstract: Studies in a variety of model organisms indicate that nutrient signaling is tightly coupled to longevity. In nutrient replete conditions, organisms develop, grow, and age quickly. When nutrients become sparse as with dietary restriction, growth and development decline, stress response pathways become induced and organisms live longer. Considerable effort has been devoted to understanding the molecular events mediating lifespan extension by dietary restriction. One central focus has been on nutrient-responsive signal transduction pathways including insulin/IGF-1, AMP kinase, protein kinase A and the TOR pathway. Here we describe the increasingly prominent links between TOR signaling and aging in invertebrates. Longevity studies in mammals are not published to date. Instead, we highlight studies in mouse models, which indicate that dampening the TOR pathway leads to widespread protection from an array of age-related diseases. [Copyright &y& Elsevier]

Abstract: Background: Inflammatory bowel disease (IBD), a chronic inflammation of the gastrointestinal tract, is characterized by a deregulation of the mucosal immune system and resistance of activated T cells to apoptosis. Current therapeutics show limited efficacy and potential toxicity; therefore there is a need for novel approaches for the treatment of IBD. L-cysteine was examined for its ability to reduce colitis symptoms and modulate local gene expression in a DSS-induced porcine model of colitis. Methods: Colitis was induced via intra-gastric infusion of dextran sodium sulfate (DSS), followed by the administration of L-cysteine or saline. Clinical signs, morphological measurements, histology and gut permeability were assessed for the prognosis of colitis. Local tissue production of cytokines and gene expression in the colon were analyzed by ELISA and real-time RT-PCR. Results: L-cysteine supplementation attenuated DSS-induced weight loss and intestinal permeability, reduced local chemokine expression and neutrophil influx, and markedly improved colon histology. Furthermore, cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-α, IL-6, IL-12p40, IL-1β, and resulted in increased expression of the apoptosis initiator caspase-8 and decreased expression of the pro-survival genes cFLIP and Bcl-xL. Conclusions and general significance: These results suggest that L-cysteine administration aids in restoring gut immune homeostasis by attenuating inflammatory responses and restoring susceptibility of activated immune cells to apoptosis, and that cysteine supplementation may be a novel therapeutic strategy for the treatment of IBD. [Copyright &y& Elsevier]

Abstract: Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. How do the biochemical properties of LA relate to its biological effects? Herein, we review the molecular mechanisms of LA discovered using cell and animal models, and the effects of LA on human subjects. Though LA has long been touted as an antioxidant, it has also been shown to improve glucose and ascorbate handling, increase eNOS activity, activate Phase II detoxification via the transcription factor Nrf2, and lower expression of MMP-9 and VCAM-1 through repression of NF-kappa B. LA and its reduced form, dihydrolipoic acid, may use their chemical properties as a redox couple to alter protein conformations by forming mixed disulfides. Beneficial effects are achieved with low micromolar levels of LA, suggesting that some of its therapeutic potential extends beyond the strict definition of an antioxidant. Current trials are investigating whether these beneficial properties of LA make it an appropriate treatment not just for diabetes, but also for the prevention of vascular disease, hypertension, and inflammation. [Copyright &y& Elsevier]

Abstract: Population aging is progressing rapidly in many industrialized countries. The United States population aged 65 and over is expected to double in size within the next 25 years. In sedentary people eating Western diets aging is associated with the development of serious chronic diseases, including type 2 diabetes mellitus, cancer and cardiovascular diseases. About 80% of adults over 65 years of age have at least one chronic disease, and 50% have at least two chronic diseases. These chronic diseases are the most important cause of illness and mortality burden, and they have become the leading driver of healthcare costs, constituting an important burden for our society. Data from epidemiological studies and clinical trials indicate that many age-associated chronic diseases can be prevented, and even reversed, with the implementation of healthy lifestyle interventions. Several recent studies suggest that more drastic interventions (i.e. calorie restriction without malnutrition and moderate protein restriction with adequate nutrition) may have additional beneficial effects on several metabolic and hormonal factors that are implicated in the biology of aging itself. Additional studies are needed to understand the complex interactions of factors that regulate aging and age-associated chronic disease. [Copyright &y& Elsevier]

Abstract: Background: Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes, cardiovascular disease, metabolic syndrome and death. Methods: Studies utilizing novel rodent models of visceral obesity and surgical strategies in humans have been undertaken to determine if subcutaneous (SC) abdominal or VF are causally linked to age-related diseases. Results: Specific depletion or expansion of the VF depot using genetic or surgical tools in rodents has been shown to have direct effects on disease risk. In contrast, surgically removing large quantities of SC fat does not consistently improve metabolic parameters in humans or rodents, while benefits were observed with SC fat expansion in mice, suggesting that SC fat accrual is not an important contributor to metabolic decline. There is also compelling evidence in humans that abdominal obesity is a stronger risk factor for mortality risk than general obesity. Likewise, we have shown that surgical removal of VF improves mean and maximum lifespan in rats, providing the first causal evidence that VF depletion may be an important underlying cause of improved lifespan with caloric restriction. General significance: This review provides both corollary and causal evidence for the importance of accounting for body fat distribution, and specifically VF, when assessing disease and mortality risk. Given the hazards of VF accumulation on health, treatment strategies aimed at selectively depleting VF should be considered as a viable tool to effectively reduce disease risk in humans. [Copyright &y& Elsevier]

Abstract: In 1935, Clive McCay and colleagues reported that decreasing the food intake of rats extends their life. This finding has been confirmed many times using rat and mouse models. The responsible dietary factor in rats is the reduced intake of energy; thus, this phenomenon is frequently referred to as caloric restriction. Although many hypotheses have been proposed during the past 74 years regarding the underlying mechanism, it is still not known. It is proposed that this lack of progress relates to the fact that most of these hypotheses have been based on a single underlying mechanism and that this is too narrow a focus. Rather, a broad framework is needed. Hormesis has been suggested as providing such a framework. Although it is likely that hormesis is involved in the actions of caloric restriction, it also is probably too narrowly focused. Based on currently available data, a provisional broad framework is presented depicting the complex of mechanisms that likely underlie the life-extending and other anti-aging actions of caloric restriction. [Copyright &y& Elsevier]

Abstract: Male life history and resource allocation is not frequently studied in aging and life span research. Here, we verify that males of long-lived fruit-feeding butterfly species have reduced longevity on restricted diets [Beck, J., 2007. The importance of amino acids in the adult diet of male tropical rainforest butterflies. Oecologia 151, 741–747], in contrast to the common finding of longevity extension in dietary restriction experiments in Drosophila and some other organisms. Males of some of the most long-lived species of fruit-feeding butterflies were collected from Kibale Forest, Uganda, and kept on diets of either sugar or mashed banana. Seven out of eight species had non-significantly longer life spans on mashed banana diets. Data analysis using a time-varying Cox-model with species as covariate showed that males had reduced survival on the sugar diet during the first 35days of captive life, but the effect was absent or reversed at more advanced ages. These results challenge the generality of dietary restriction as a way to extend life span in animals. We argue that such studies on males are promising tools for better understanding life history evolution and aging because males display a wider variety of tactics for obtaining reproductive success than females. [Copyright &y& Elsevier]

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species. [ABSTRACT FROM AUTHOR]

Abstract: Nutrition offers the means to improve health and well-being and among the predictive factors of successful aging, nutrition appears as one of the major determinants. Whereas adequate nutrition plays a major role in a healthy lifestyle that maintains bodily and mental functioning, inadequate nutrition contributes to a loss of function and to the development and progression of disease. At the moment recommended dietary allowance (RDA) is established to cover the needs of populations of the healthy elderly. In the future special recommendations for subgroups of individuals are essential, taking into account individual health status and genetic factors. Nutrient guidelines for elderly are basically the same as for young adults, propagating a balanced varied nutrition that is rich in complex carbohydrate sources, fruits and vegetables providing fiber, antioxidant and functional nutrients, fish providing vitamin D and essential fatty acids, adequate water supply in view of their potentially impaired thirst perception and reduced renal functions. Finally a balanced diet is the best way to avoid deficiencies and maintain health. If in subgroups of the elderly population an adequate nutrition cannot be achieved, low dose dietary supplements and/or fortified foods and beverages can contribute to improve nutrient intake. [Copyright &y& Elsevier]

Information about several topics discussed at a conference on studies related to the role of diet and lifestyle in the ageing process, held at the Sainsbury's Conference Centre, London, England on January 13, 2009, is presented. Topics include the use of Mediterranean diet for increasing longevity, the impact of diet and lifestyle on heart diseases, arthritis, bone and mental health. The symposium featured several researchers including Robert Clarke, Susan Lanham-New, and Paul Dieppe.

We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput yeast two-hybrid searches. The longevity network is composed of 175 human homologs of proteins known to confer increased longevity through loss of function in yeast, nematode, or fly, and 2,163 additional human proteins that interact with these homologs. Overall, the network consists of 3,271 binary interactions among 2,338 unique proteins. A comparison of the average node degree of the human longevity homologs with random sets of proteins in the Core Network indicates that human homologs of longevity proteins are highly connected hubs with a mean node degree of 18.8 partners. Shortest path length analysis shows that proteins in this network are significantly more connected than would be expected by chance. To examine the relationship of this network to human aging phenotypes, we compared the genes encoding longevity network proteins to genes known to be changed transcriptionally during aging in human muscle. In the case of both the longevity protein homologs and their interactors, we observed enrichments for differentially expressed genes in the network. To determine whether homologs of human longevity interacting proteins can modulate life span in invertebrates, homologs of 18 human FRAP1 interacting proteins showing significant changes in human aging muscle were tested for effects on nematode life span using RNAi. Of 18 genes tested, 33% extended life span when knocked-down in Caenorhabditis elegans. These observations indicate that a broad class of longevity genes identified in invertebrate models of aging have relevance to human aging. They also indicate that the longevity protein interaction network presented here is enriched for novel conserved longevity proteins. [ABSTRACT FROM AUTHOR]

Background: An index of diet quality, which examines different aspects of a diet concurrently, may facilitate the identification of poor dietary habits in population sub-groups. The objectives of the present study were to develop a food frequency index (FFI) and to test its associations with nutritional biomarkers and nutrient intake. Methods: The study comprised a cross-sectional survey among 444 adults aged 55 years and older in Vienna, Austria, and a sub-sample of 226 subjects who provided fasting blood specimen. Data from a qualitative 28-item food-frequency questionnaire were used to develop the FFI. Results: FFI scores were positively correlated with plasma concentrations of beta-carotene ( r = 0.26), beta-cryptoxanthin ( r = 0.31), zeaxanthin ( r = 0.19), lutein ( r = 0.21), phylloquinone ( r = 0.19), 25-hydroxyvitamin D ( r = 0.20), and serum high-density lipoprotein (HDL)-cholesterol ( r = 0.24) and were negatively correlated with the ratio of total : HDL-cholesterol ( r = −0.23). Sub-groups with higher FFI scores had, on average, lower intakes of total fat, saturated fat, and dietary cholesterol and higher intakes of total carbohydrates, dietary fibre, and most of the examined micronutrients. Conclusion: The FFI as a measure of diet quality has the ability to discern population sub-groups, with reasonable validity, into low- or high-risk dietary habits. [ABSTRACT FROM AUTHOR]

Background The elderly are particularly prone to zinc deficiency because of nutritional and physiological vulnerabilities associated with ageing. A low socio-economic status may further increase the risk of zinc deficiency. This cross-sectional descriptive study assessed the zinc status of an elderly sample in the Vaal region, South Africa. Methods The participants were 170 randomly selected elderly people attending a day care centre in Sharpeville. Twenty-four-hour recalls were administered for dietary intake. Weight and height were measured and venous blood samples ( n = 67) were drawn to determine biochemical indices. Results The mean age of the respondents was 71.7 years. The mean ± SD daily dietary intake for zinc was 11.0 ± 6.12 mg. Approximately half of the subjects (51.5%) did not reach two-thirds of the recommended dietary allowance for zinc. The mean serum zinc concentration was 61.8 ± 8.5 μg dL−1 (9.4 ± 1.3 μmol L−1), with 76.3% of the subjects having zinc values less than the recommended values of 70 μg dL−1 (10.7 μmol L−1). Maize meal was the staple in the diet of approximately half the study population. Although South African maize meal is now fortified with zinc oxide, maize also contains high concentrations of phytate, a known inhibitor of mineral bioavailability. Conclusions The results of the present study suggested that zinc deficiency existed in these elderly people. Further research is, however, needed to elucidate possible underlying factors so that appropriate intervention can be implemented. [ABSTRACT FROM AUTHOR]

Nutrient signaling has recently shown how nutraceuticals regulate specific functions of the brain and adipose tissue. In this pilot study to find an effective nutrient signaling system to cause weight loss, a double-blind placebo-controlled trial using leucine, olive oil, and fish oil was conducted on volunteers to signal metabolic and appetite effects to regulate body weight, while controls took only fiber. Men and women aged 18–26 and 39–62 years were given different dosages that they took orally twice daily for 14 days while recording body weight, followed by 2 weeks to check rebound. Most young men and women lost weight on low dose leucine and olive oil. Mature men required higher doses. Mature women’s weight was affected least, though results are consistent with a hypothesis that sufficient leucine and docosahexaenoic acid would be effective. Determining how age affects signaling pathways by nutrients will be important to reduce risk of chronic disease associated with age and obesity. This pilot study has led to hypotheses of practical strategies. [ABSTRACT FROM AUTHOR]

A healthy child who achieves both their peak of physical fitness and their optimal nutritional status is more likely to progress through the life-span as a healthy adult. However, children, adults and older adults in the UK are failing to achieve both adequate nutritional and fitness status. Individuals are now living longer due to improved social conditions and advances in medical care. Despite this, many children, adults and those aged 65 years and over are suffering from malnutrition or obesity. The second part of this article seeks to educate healthcare professionals regarding the nutritional requirements for school-age children, adolescents and adults between the ages of 19 and 64 years. The nutritional requirements of older adults aged 65 years and over, including a review on nutritional support within this age group, will be addressed in a further article. Healthcare professionals have a responsibility to assist the population in achieving their optimal nutritional status. This may be achieved through health promotion, which, if appropriate, may instigate and sustain behavioural change in relation to both nutritional habits and physical exercise. [ABSTRACT FROM AUTHOR]

Introduction: Oxidative stress is one mechanism that could contribute to the acceleration of aging and age-related diseases. On the other hand, because of their antioxidative qualities soybean derived foods could have beneficial effects on the aging process. Objectives: The aim of our work was to study the effects of a diet supplemented with soy milk on certain biological features of aging in rats Methods: Male Wistar rats of 3 to 18 months of age, were assigned to one of two diets: 1) Experimental Group, commercial rat formula and soy milk; 2) Control Group, commercial rat formula and water. Every three months both lipid profile and lipid peroxidation were determined and neuronal cells of hippocampus were counted in control and experimental rats. Results: The soy milk diet significantly improved the plasmatic lipid profile, decreasing serum cholesterol (total as well as LDL) and serum triglycerides, HDL-cholesterol was significatively higher in experimental animals. The LDL/HDL ratio was thus significantly lowered. The soy diet also produced decreased values of lipid peroxidation in brain, liver and kidney. These effects were significant after 6 to 9 months. The experimental animals lost fewer hippocampal neurons than the controls. Finally at 18 months of age, a greater number of surviving animals in experimental group with respect to the control one was observed. Conclusions: 1) soy intake could have beneficial effects as a complement of normal diet, but not as a replacement for animal proteins and 2) these effects are the result of a very long period (almost lifelong) of consumption of this diet. [ABSTRACT FROM AUTHOR]

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The article discusses the findings of an expert panel titled Carla Workshop, which met in France in November 2007, to review the role of nutrition in cancer and aging. Topics discussed include osteoporosis, the presence of anorexia in aging people, and sarcopenia. Plant foods, diary products, and antioxidants are among numerous nutritional factors that impact cancer and aging. Malnutrition and long-term care are also discussed.

The article presents a study which examines the effect of prebiotic galactooligosaccharides (B-GOSs) on immune function and fecal microflora composition in older people. Details about the subjects and methods used are offered, including subjects and study design, preparation and collection of fecal samples, and analysis of plasma total cholesterol. Result of the study reveals that administration of B-GOS to healthy subjects have positive effects on microflora composition and immune response.

Reduced function mutations in the insulin/IGF-I signaling pathway increase maximal lifespan and health span in many species. Calorie restriction (CR) decreases serum IGF-1 concentration by ~40%, protects against cancer and slows aging in rodents. However, the long-term effects of CR with adequate nutrition on circulating IGF-1 levels in humans are unknown. Here we report data from two long-term CR studies (1 and 6 years) showing that severe CR without malnutrition did not change IGF-1 and IGF-1 : IGFBP-3 ratio levels in humans. In contrast, total and free IGF-1 concentrations were significantly lower in moderately protein-restricted individuals. Reducing protein intake from an average of 1.67 g kg−1 of body weight per day to 0.95 g kg−1 of body weight per day for 3 weeks in six volunteers practicing CR resulted in a reduction in serum IGF-1 from 194 ng mL−1 to 152 ng mL−1. These findings demonstrate that, unlike in rodents, long-term severe CR does not reduce serum IGF-1 concentration and IGF-1 : IGFBP-3 ratio in humans. In addition, our data provide evidence that protein intake is a key determinant of circulating IGF-1 levels in humans, and suggest that reduced protein intake may become an important component of anticancer and anti-aging dietary interventions. [ABSTRACT FROM AUTHOR]

Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders. [ABSTRACT FROM AUTHOR]

Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discemable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroen-docrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general. [ABSTRACT FROM AUTHOR]

As companion animals age and pass through various life stages from in utero to the geriatric state, nutrient requirements change along with the manner in which nutrients are utilized by the various organ systems in the body. From the regulatory perspective, recognized life stages include maintenance, growth, and gestation/lactation. Other important life stages include in utero, the neonate, and the senior/geriatric state. Age affects digestive physiological properties, too, and factors such as gut microbiota, digestive hormones, gut morphology, gut immunity, and nutrient digestibility are modified as the animal becomes older. Each of the nutrients is affected in some manner by age, some more than others. Genomic biology offers promise in helping elucidate in greater detail how nutrient utilization is affected by age of the dog and cat. [ABSTRACT FROM AUTHOR]

Approximately 36% of the rural Australian population is 65 years and older. In fact, many rural and remote communities have higher proportions of older people than metropolitan centres. The rate of growth, patterns of migration, higher levels of health risk factors and of social and economic disadvantage all impact on rural healthy ageing. Older people in rural communities have become marginalised by longstanding misconceptions about rural life and urban-centric policies, much of which goes unchallenged because of a paucity of research in key areas and a lack of intrarural research. Understanding the complexities of rural healthy ageing is challenging, and more research is required to develop a stronger empirical base. The aim of this review is to critique the literature related to rural ageing in Australia to identify the issues and challenges for rural healthy ageing and implications for policy and practice. [ABSTRACT FROM AUTHOR]

AIM: This paper is a report of a study of the health and ageing concerns and self-care strategies of older female Registered Nurses currently working in direct care-giving roles in acute public hospitals and community facilities. BACKGROUND: Nursing is a rapidly ageing, and female-dominated workforce. However, despite the ageing of the nursing workforce, little is known about the needs and health concerns of older nurses. METHOD: A feminist perspective was used and 12 female Registered Nurses aged 40-60 years, employed in various acute hospital and community health settings in Australia took part in qualitative interviews in late 2004. Narratives were audio taped, transcribed and analysed thematically. FINDINGS: Two major themes were identified. The first theme -Aches and pains of ageing- had four subthemes: Neglecting self: 'You don't think of yourself first'; Physical changes: 'The body is wearing out'; Living with pain: 'You just work around it'; and Tiredness: 'I'm just tired all the time'. The second theme -Evolving lifestyles: works in progress - had three subthemes: The power of exercise: 'I feel great...and I'm enjoying life'; Healthy eating: 'Low fat, lots of fruit and veg, little processed food'; and Adapting to ageing: 'I think it's quite a good time of life'. CONCLUSION: Further research is needed to explore the need for protective work practices and promoting healthy lifestyle practices for ageing nurses. Managers need to recognize the changing health needs of older clinical nurses and offer, for example, flexible rostering and tailored exercise programmes to promote their health. [ABSTRACT FROM AUTHOR]

Accumulating evidence suggests that aging is associated with dysregulated immune and inflammatory responses. Investigation into the cellular and molecular mechanisms underlying this phenomenon suggests that an up-regulated cyclooxygenase (COX)-2 expression, and resulting increase in production of prostaglandin E2 (PGE2), is a critical factor. Macrophages from old mice have significantly higher levels of PGE2 production compared with those from young mice, a result of increased COX-2 expression and protein levels leading to increased COX enzyme activity. Further, it is possible that the age-associated increase in macrophage PGE2 production is due to ceramide-induced up-regulation of nuclear factor-kappa B activation. Such processes may also occur in cell types other than macrophages, lending further insight into potential mechanisms of age-related disease. More research is necessary to determine the efficacy of nutrient/dietary modifications, such as antioxidants and lipids, for reducing the age-related increase in COX activity and PGE2 production that are associated with several disease states. [ABSTRACT FROM AUTHOR]

Worldwide, the population is aging, with estimates of 1 billion people aged 60 y or over within the next 20 y. With aging comes a reduction in overall health and increased morbidity and mortality due to infectious disease. Mortality due to gastrointestinal infections is up to 400 times higher in the elderly compared with younger adults. Recent studies have shown that the gut microbiota changes in old age, with an increased number of bacterial groups represented in the predominant elderly gut microbiota. This change in species "evenness" coincides with parallel changes in immune function, diet, and lifestyle and may contribute to disease susceptibility and severity in old age. The intestinal microbiota may thus be identified as an important target for improving health through reduced disease risk. Here, the application of prebiotics, especially the inulin-type fructans, and synbiotics (prebiotics combined with efficacious probiotic strains) will be discussed in terms of microbiota modulation and impact on disease risk in the aged population. Recent human intervention studies have confirmed the microbiota modulatory capability of the inulin-type fructans in the elderly and there is some evidence for reduced risk of disease. However, there is a need for more and larger human intervention studies to determine the efficacy of prebiotics in the elderly, particularly studies that take advantage of recent high resolution analytical methodologies like metabonomics, to shed light on possible prebiotic mechanisms of action. [ABSTRACT FROM AUTHOR]

Older people develop special nutritional requirements and acquire dietary habits that put them at increased risk of various nutritional deficits. Aging and nutritional decays act in conjunction with diseases, medications, and economic constraints to diminish overall health in elderly patients. [ABSTRACT FROM AUTHOR]