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51. Le by-pass gastrique laparoscopique avec assistance robotique n’est pas plus long ni plus morbide que le by-pass gastrique par voie laparoscopique classique

Author

C. Kuperas, Olivier Facy, T. Kratz, P. Rat, B. Borraccino, Alexandre Doussot, A. Soudry Faure, Nicolas Santucci, and J.-J. Sala

Subjects
Gynecology, medicine.medical_specialty, Nutrition and Dietetics, Philosophy, medicine, General Medicine, Quality of Life Research
Abstract

Cette etude retrospective evalue la faisabilite et la morbimortalite de l’assistance robotique pour realiser un bypass gastrique avec une anse en Y montee en precolique comparee a la voie laparoscopique. Elle compare les 100 premiers by-pass avec assistance robotique aux 100 premiers by-pass par laparoscopie d’un meme operateur. Il n’y a pas de difference de duree operatoire ou de morbimortalite entre les deux groupes. L’assistance robotique pour realiser un bypass gastrique est faisable et fiable, meme lors de la periode d’apprentissage.

Published
2017
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53. Cerebral Infarct Topography and Early Outcome after Surgery for Symptomatic Carotid Stenosis: A Multicentre Study

Author

Réda Hassen-Khodja, Elixène Jean-Baptiste, Fabien Lareyre, Eric Steinmetz, Yannick Béjot, Sergueï Malikov, Nicla Settembre, Agnès Soudry-Faure, Benjamin Kretz, and Caroline Kazandjian

Subjects
Male, medicine.medical_specialty, Time Factors, Databases, Factual, medicine.medical_treatment, Clinical Decision-Making, Carotid endarterectomy, 030204 cardiovascular system & hematology, Severity of Illness Index, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, T-group, Postoperative stroke, Risk Factors, Humans, Medicine, Carotid Stenosis, Cerebral infarcts, Stroke, Aged, Retrospective Studies, Endarterectomy, Aged, 80 and over, Endarterectomy, Carotid, business.industry, Mortality rate, Cerebral Infarction, Middle Aged, medicine.disease, Surgery, Stenosis, Treatment Outcome, Neurology, Anesthesia, Female, France, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Abstract

Introduction: Although carotid stenosis can cause both territorial and border-zone (BZ) cerebral infarcts (CI), the influence of CI topography on postoperative complications after surgery remains unclear. We compared early outcomes after endarterectomy on the basis of CI location: territorial (T group) or BZ group. Material and Methods: During the period between 2009 and 2013, ischaemic stroke patients who had undergone surgery for symptomatic carotid stenosis were identified from prospective databases from 3 French centres. The outcome was the identification of a combined stroke/death rate 30 days after endarterectomy. Results: Two hundred and eighty-nine patients were included, 216 (74.7%) in the T group and 73 (25.3%) in the BZ group. The mean degree of stenosis was comparable in the 2 groups (78 ± 12% in the T group vs. 80 ± 12% in the BZ group, p = 0.105), with, however, more sub-occlusions (stenosis >90%) in the BZ group (38.4 vs. 23.1%, p = 0.012). The mean time between the time CI developed and the time surgery was performed was 19.6 ± 24.8 days, with a majority of patients being operated upon within 2 weeks following the formation of CI (66.7% in the T group vs. 60.3% in the BZ group, p = 0.322). The combined endpoint was significantly more frequent in the BZ group (9.6 vs. 1.9%, p = 0.003), with 4 ischaemic strokes and 3 deaths. In multivariate analysis, BZ CI was an independent predictor of postoperative stroke or death at 30 days (HR 4.91-95% CI [1.3-18.9], p = 0.020). Conclusion: BZ infarcts carry a greater risk of postoperative complications after carotid surgery, thus suggesting that topography of the CI should be considered in the decision-making process regarding surgery.

Published
2017
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54. Contents Vol. 44, 2017

Author

Aurélien Nouet, Huaiming Wang, Alice Jacquens, Wei Wang, Yue Wan, Agnès Soudry-Faure, Xintong Liu, Penghua Lv, Fabrizio Ricci, Yuxiu Liu, Bruno Bartolini, Erik Nilsson, Flávio Domingues, Christian Foerch, Martine T. B. Truijman, Werner H. Mess, Martin Magnusson, Katarina Nägga, Raf H. M. van Hoof, Martin Bendszus, Haowen Xu, Wenjie Zi, Yannick Béjot, Michael Frankel, Nicla Settembre, Young Hee Sung, Joachim E. Wildberger, Sriramya Lapa, Floris H.B.M. Schreuder, Tobien H.C.M.L. Schreuder, Robert J. van Oostenbrugge, João Thiago Frossard, Vincent Degos, Dong-Jin Shin, Srikant Rangaraju, Meredith Bowen, Mehdi Bouslama, Meng Zhang, M. Laible, Gelin Xu, Ping Jin, Wolf-Dieter Heiss, Jin Wook Kim, Elixène Jean-Baptiste, Frédéric Clarençon, Johannes Pfaff, M. Eline Kooi, Idriss Haffaf, Fuqiang Guo, Yonggang Hao, Xinfeng Liu, Eimad Shotar, Ekkehart Jenetzky, Hua Li, Olle Melander, Zhonghua Shi, Anke Bergmann, Silvia Pistocchi, Raul G Nogueira, Benjamin Kretz, Min Lin, Jorge Paes Barreto Marcondes de Souza, Wenhua Liu, Oskar Hansson, Erasmus Bachus, Min-Ju Kang, Peter A. Ringleb, Fabien Lareyre, Seena Dehkharghani, Hannes Holm, Narender P. van Orshoven, Eric Steinmetz, Zhen Wang, Yunyun Xiong, Yu Geng, Druckerei Stückle, Eung Yeop Kim, Diogo C Haussen, Christian Henke, Patty J. Nelemans, Nader-Antoine Sourour, Jonathan A Grossberg, Dong Yang, Xiguang Tian, Dequan Zheng, Artur Fedorowski, Réda Hassen-Khodja, Guodong Xiao, Eduardo Cinosi, Leticia C Rebello, Jacques Chiras, Zhiming Zhou, Dong Hoon Shin, Sergueï Malikov, Mingyi Tu, Shuiping Wang, Caroline Kazandjian, Vitor Chehuen Bicalho, Sylvia Heeneman, Markus A Möhlenbruch, Hyeon-Mi Park, and Timolaos Rizos

Subjects
Neurology, Traditional medicine, business.industry, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Published
2017
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55. Intérêt de la TEP céphalique pour le diagnostic d’artérite à cellules géantes

Author

Bernard Bonnotte, Sylvain Audia, A. Soudry-Faure, Maxime Samson, A. Ramon, Catherine Creuzot-Garcher, Laurent Martin, H. Greigert, B. Durand-Bailloud, N. Falvo, Hervé Devilliers, J.L. Alberini, T. Thibault, and A. Cochet

Subjects
Gastroenterology, Internal Medicine
Abstract

Introduction La realisation d’une biopsie d’artere temporale (BAT) reste l’examen de reference pour le diagnostic d’arterite a cellules geantes (ACG) mais est un geste invasif qui manque de sensibilite. Les techniques d’imagerie vasculaire, qui permettent de montrer des signes indirects de vascularite de l’artere temporale, de l’aorte ou d’autres gros vaisseaux, ont donc une place grandissante pour le diagnostic d’ACG. Les appareils de TEP-TDM numerique nouvelle generation permettent desormais l’etude des arteres cephaliques avec une tres bonne resolution, en plus de l’etude de l’aorte et de ses branches (1). L’objectif de cette etude etait d’evaluer les performances diagnostiques de la TEP-FDG cephalique au cours de l’ACG. Materiels et methodes Entre novembre 2018 et juillet 2020, une TEP-FDG cephalique a ete realisee chez tous les patients suspects d’ACG du service de Medecine interne et immunologie clinique. En cas de traitement par corticoides debute depuis plus de 72 h, de BAT realisee avant la TEP-FDG, de glycemie capillaire superieure a 7 mmol/L le jour de la TEP, d’âge inferieur a 50 ans ou de TEP realisee dans le cadre du suivi, les patients ont ete exclus de l’analyse. Une etude de 20 segments vasculaires, dont 8 cephaliques, a ete realisee en determinant pour chaque segment le grade (0 a 3) de l’hypermetabolisme par rapport au bruit de fond hepatique (2). La TEP cephalique etait consideree comme positive si au moins 2 segments cephaliques presentaient un hypermetabolisme de grade ≥ 2. La TEP des vaisseaux extra-cephaliques etait consideree comme positive en cas d’hypermetabolisme de grade ≥ 2 d’au moins un segment arteriel. Un diagnostic final d’ACG etait retenu en cas de signe(s) clinique(s) compatible(s) et de prescription d’une corticotherapie pendant plus de 6 mois consecutifs. Resultats Une TEP cephalique a ete realisee chez 111 patients dont 51 remplissaient les criteres d’inclusion. Parmi eux, 15/51 (29,4 %) presentaient un diagnostic final d’ACG. Parmi ces 15 patients, 7 avaient une ACG cephalique pure, 2 une ACG extra-cephalique pure et 6 une ACG cephalique et extra-cephalique. Tous les patients chez qui le diagnostic d’ACG a ete retenu remplissaient au moins 3 des 5 criteres de l’ACR.[3] La BAT a ete realisee chez 32/51 (62,7 %) patients et etait positive dans 10/32 cas (31,3 %). Dans notre etude, la BAT avait une sensibilite de 71,4 % et une specificite de 100 % pour le diagnostic d’ACG. La VPP et la VPN de la BAT etaient respectivement de 100 % et 81,8 %. Le coefficient kappa, evaluant la concordance entre les resultats de la TEP cephalique et ceux de la BAT, etait de 0,56 [0,25–0,87]. La TEP des vaisseaux extra-cephalique avait une sensibilite de 53,3 % et une specificite de 97,2 % avec une VPP et une VPN de respectivement 88,9 % et 83,3 %. La TEP cephalique avait une sensibilite de 73,3 % et une specificite de 97,2 % avec une VPP et une VPN de respectivement 91,7 % et 89,7 %. L’association des resultats de la TEP cephalique et de la TEP extra-cephalique permettait d’obtenir une sensibilite de 80 % et une specificite de 94,4 %. La VVP et la VPN de l’association TEP cephalique + TEP extra-cephalique etaient respectivement de 85,7 % et 91,9 %. La courbe ROC analysant la valeur diagnostique du ratio « SUV maximale des vaisseaux cephaliques/SUV hepatique » avec pour reference le diagnostic clinique d’ACG avait une aire sous la courbe de 0,95 avec une sensibilite de 100 % et une specificite de 80,6 % pour un seuil a 0,7, de 86,7 % et 88,9 % pour un seuil a 0,77 et de 60 % et 97,2 % pour un seuil a 0,97. Discussion Meme si le petit nombre de patients atteints d’ACG et la sur-representation des formes cephaliques sont les deux principales limites de cette etude, nos resultats confirment l’interet diagnostique de la TEP cephalique au cours de l’ACG [1] et suggerent qu’un ratio « SUV maximale de vaisseaux cephaliques/SUV hepatique » inferieur a 0,7 rendrait tres improbable le diagnostic d’ACG. Conclusion La TEP-TDM des arteres cephaliques, surtout lorsqu’elle est couplee a la TEP-TDM corps entier, presente d’excellentes performances diagnostiques pour l’ACG. Des travaux sont necessaires pour mieux determiner le niveau d’hypermetabolisme de l’artere temporale cliniquement significatif.

Published
2020
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56. Oral water ingestion in the treatment of shock patients: a prospective randomized study

Author

Maxime Nguyen, Pierre-Grégoire Guinot, Belaid Bouhemad, Valerian Duclos, and Agnes Soudry-Faure

Subjects
medicine.medical_specialty, business.industry, Pain medicine, Anesthesiology, Shock (circulatory), Emergency medicine, medicine, MEDLINE, Prospective randomized study, medicine.symptom, Critical Care and Intensive Care Medicine, business, Water ingestion
Published
2020
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57. Evaluation of anti-Xa activity after injection of a heparin lock for dialysis catheters in intensive care: A prospective observational study

Author

Julie Helms, Agnès Soudry-Faure, Julien Bovet, Hamid Merdji, Jean-Pierre Quenot, Elea Ksiazek, Amélie Cransac, and Ferhat Meziani

Subjects
medicine.medical_specialty, Catheterization, Central Venous, Critical Care, medicine.medical_treatment, MEDLINE, law.invention, Catheterization, Heparin lock, Heparin locks, Catheters, Indwelling, law, Renal Dialysis, Intensive care, medicine, Central Venous Catheters, Humans, Renal replacement therapy, Intensive care medicine, business.industry, Heparin, Anticoagulants, Hematology, Intensive care unit, Observational study, Dialysis (biochemistry), business
Published
2019

58. [A caregiver-person with schizophrenia partnership to improve oral health education]

Author

Corinne, Rat, Audrey, Peteuil, Matthieu, Reynaud, Isabelle, Millot, Maud, Carpentier, Agnès, Soudry-Faure, and Frederic, Denis

Subjects
Caregivers, Patient Education as Topic, Schizophrenia, Feasibility Studies, Humans, Oral Health, France, Focus Groups
Abstract

Poor oral health in persons with schizophrenia is a major public health issue affecting 600,000 people in France. The aim of this article was to present the different stages in the development of a specific oral health educational program for persons with schizophrenia. It takes into account experimental knowledge of these persons and presents the results of the feasibility study.The focus group method was applied to a group of health professionals and users to highlight an exploratory corpus in order to develop an oral health educational program. An expert group including persons with schizophrenia among others validated the fields and tools of this program. A feasibility study was then conducted in a control group of 7 persons with schizophrenia.Altogether, 26 persons participated in this feasibility study. The main fields investigated by the expert group aimed to promote personal responsibility for one’s health, to improve access to the healthcare system and to promote the global management of health. The feasibility study showed the ability of this program to change persons with schizophrenia representations and knowledge of this health problem. Most educational tools were considered relevant.An oral health educational program was built as part of a caregiver-persons with schizophrenia partnership and showed its feasibility. A multicentric randomized trial is currently ongoing to assess the efficacy of this program with a high level of proof.

Published
2019

59. MOESM1 of Trisodium citrate 4% versus heparin as a catheter lock for non-tunneled hemodialysis catheters in critically ill patients: a multicenter, randomized clinical trial

Author

Quenot, Jean-Pierre, Helms, Julie, Abderrahmane Bourredjem, Dargent, Auguste, Meziani, Ferhat, Badie, Julio, Blasco, Gilles, Piton, Gaël, Capellier, Gilles, Chaouki Mezher, Jean-Michel Rebibou, Abdelouaid Nadji, Crepin, Thomas, Barbar, Saber, Fleck, Camille, Cransac, Amélie, Boulin, Mathieu, Binquet, Christine, Soudry-Faure, Agnès, and Bruyère, Rémi

Abstract

Additional file 1. Online supplement containing additional information relating to the methods, as well as author contributions and the full list of co-investigators in the VERROU-REA Study group.

Published
2019
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61. Étude des algorithmes de repérage de la dépression dans le SNIIRAM par le réseau REDSIAM

Author

Cédric Collin, Anne-Sophie Mariet, Johan Besson, Agnès Soudry-Faure, Adrien Roussot, Catherine Quantin, Marie Jeanne Bismuth, Jonathan Cottenet, and François Cousin

Subjects
General Medicine
Abstract

Le Systeme national d’information interregimes de l’assurance maladie (SNIIRAM) est une source de donnees medico-administrative de sante quasi exhaustive de la population francaise, reunissant les donnees de remboursement de soins de ville et d’hospitalisation. Compte tenu du nombre croissant d’utilisateurs des donnees du SNIIRAM a des fins d’etudes, de recherche et de surveillance epidemiologique, le reseau REDSIAM a pour objectif de favoriser l’interaction entre utilisateurs, de valider et de promouvoir les methodes d’analyses issues des donnees. Au sein de ce reseau, le groupe de travail Troubles mentaux et du comportement (GT-TMC) s’est interesse aux algorithmes d’identification de la depression de l’adulte a partir des donnees du SNIIRAM. Il apparait en effet que les pathologies psychiatriques, et notamment la depression, ont ete peu etudiees a partir des bases de donnees medico-administratives. La methodologie s’est appuyee sur l’interview de dix experts ayant deja travaille sur le SNIIRAM, a partir de questionnaires valides. La synthese des entretiens montre que les algorithmes doivent s’adapter aux objectifs specifiques poursuivis par les etudes et dependent du type d’enquete realisee, du type de depression, du perimetre de donnees interrogees et de l’association ou non aux donnees de consommation medicamenteuse.

Published
2016
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64. Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network

Author

Quantin, Catherine, Collin, Cédric, Frérot, Mathilde, Besson, Johan, Cottenet, Jonathan, Corneloup, Marie, Soudry-Faure, Agnès, Mariet, Anne-Sophie, Roussot, Adrien, Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses ( B2PHI ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service Biostatistiques et Informatique Médicale (CHU de Dijon) ( DIM ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques ( CIC-EC ), Université de Bourgogne ( UB ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Direction scientifique et de la stratégie européenne [Saint-Denis], Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] ( ANSM ), Service de santé publique et médecine sociale [CHU Dijon], Unité de soutien méthodologique [CHU Dijon], Délégation à la recherche clinique et à l'innovation [CHU Dijon] ( DRCI ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Groupe REDSIAM–Troubles mentaux et du comportement : Réseau national pour la validation des algorithmes utilisés pour identifier des cas de pathologies dans le programme de médicalisation des systèmes d’information (PMSI), Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses (B2PHI), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Biostatistiques et Informatique Médicale (CHU de Dijon) (DIM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] (ANSM), Délégation à la recherche clinique et à l'innovation [CHU Dijon] (DRCI), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Information Services, Santé mentale, Databases, Factual, Medical Records Systems, Computerized, National Health Programs, RIM-P, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, PMSI, Hospitalization, Outpatients, Critical Pathways, Schizophrenia, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Mental health, France, Schizophrénie, Algorithms, Antipsychotic Agents, Sniiram
Abstract

International audience; BACKGROUND:The aim of the REDSIAM network is to foster communication between users of French medico-administrative databases and to validate and promote analysis methods suitable for the data. Within this network, the working group "Mental and behavioral disorders" took an interest in algorithms to identify adult schizophrenia in the SNIIRAM database and inventoried identification criteria for patients with schizophrenia in these databases.METHODS:The methodology was based on interviews with nine experts in schizophrenia concerning the procedures they use to identify patients with schizophrenia disorders in databases. The interviews were based on a questionnaire and conducted by telephone.RESULTS:The synthesis of the interviews showed that the SNIIRAM contains various tables which allow coders to identify patients suffering from schizophrenia: chronic disease status, drugs and hospitalizations. Taken separately, these criteria were not sufficient to recognize patients with schizophrenia, an algorithm should be based on all of them. Apparently, only one-third of people living with schizophrenia benefit from the longstanding disease status. Not all patients are hospitalized, and coding for diagnoses at the hospitalization, notably for short stays in medicine, surgery or obstetrics departments, is not exhaustive. As for treatment with antipsychotics, it is not specific enough as such treatments are also prescribed to patients with bipolar disorders, or even other disorders. It seems appropriate to combine these complementary criteria, while keeping in mind out-patient care (every year 80,000 patients are seen exclusively in an outpatient setting), even if these data are difficult to link with other information. Finally, the experts made three propositions for selection algorithms of patients with schizophrenia.CONCLUSION:Patients with schizophrenia can be relatively accurately identified using SNIIRAM data. Different combinations of the selected criteria must be used depending on the objectives and they must be related to an appropriate length of time.; Position du problèmeLe réseau REDSIAM a pour objectif de favoriser la communication entre les utilisateurs des bases de données contenues dans le Sniiram, de valider et de promouvoir les méthodes d’analyses de ces données. Au sein de ce réseau, le groupe de travail « Troubles mentaux et du comportement » s’est intéressé aux algorithmes d’identification de la schizophrénie de l’adulte dans le Sniiram et a recensé au cours d’entretiens avec des experts, les critères d’identification des patients souffrant de cette pathologie.MéthodeAprès un travail de bibliographie, neuf experts de la schizophrénie ont été interrogés sur leurs procédés de repérage des patients vivant avec un trouble schizophrénique dans le Sniiram. Les entretiens ont eu lieu par téléphone, à partir d’un questionnaire.RésultatsLa synthèse des entretiens montre que le Sniiram contient différentes bases permettant le repérage des patients souffrant de schizophrénie : celle des ALD, celle des hospitalisations et celle relative aux traitements médicamenteux. Pour être le plus complet possible, un algorithme devrait s’appuyer sur l’ensemble des critères de repérage évoqués par les partenaires et présents dans ces bases. En effet, seul un tiers des personnes vivant avec un trouble schizophrénique semble bénéficier d’une ALD. Tous les patients ne sont pas hospitalisés et le codage des diagnostics lors d’hospitalisations, notamment en court-séjour MCO, n’est pas exhaustif. Pris séparément, les traitements antipsychotiques ne peuvent être employés comme critère de repérage car ils sont également délivrés à des patients souffrant de troubles bipolaires, voire à des patients présentant d’autres troubles. Il semble opportun de combiner ces critères complémentaires. Les experts ont attiré l’attention sur les prises en charge en ambulatoire, qui concernent près de 80 000 patients sans autre forme de suivi, même si celles-ci sont difficiles à chaîner avec les autres informations. Trois propositions d’algorithmes ont été faites par des experts, chacune combinant l’ensemble des critères évoqués.ConclusionUne identification des patients atteints de schizophrénie et pris en charge pour cette pathologie semble possible dans le Sniiram. Différentes combinaisons des critères retenus doivent être utilisées en fonction des objectifs poursuivis, sur une période adaptée.

Published
2017
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65. Screening for Retinopathy of Prematurity: Insight into Optimizing Screening

Author

Agnès Soudry Faure, Catherine Creuzot-Garcher, Ninon Ternoy, Claude Speeg Schatz, Niyazi Acar, Camille Charvy, Charlotte Pallot, Alain M. Bron, Claire Langlet Muteau, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpitaux Universitaires de Strasbourg, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), and Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Male, medicine.medical_specialty, retina, Birth weight, Population, Gestational Age, Diagnostic Techniques, Ophthalmological, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Medicine, Humans, Mass Screening, Retinopathy of Prematurity, 030212 general & internal medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, education, Mass screening, Retrospective Studies, education.field_of_study, medicine.diagnostic_test, business.industry, Obstetrics, prematurity, Fundus photography, Postmenstrual Age, Infant, Newborn, Gestational age, Infant, Retinopathy of prematurity, General Medicine, medicine.disease, Respiration, Artificial, Sensory Systems, eye diseases, Ophthalmology, Postnatal age, Multivariate Analysis, 030221 ophthalmology & optometry, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Purpose: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening. Methods: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera. Population and follow-up characteristics were recorded. Results: Among the 1,266 preterm infants observed, 795 were retained for analysis. One hundred seventy-four (21.6%) cases of ROP were detected with the first examination performed at 32.3 ± 1.6 weeks of postmenstrual age (PMA) and 5.4 ± 1.0 weeks of postnatal age (PNA). The first signs of ROP were detected at 34.0 ± 1.9 weeks of PMA and 7.2 ± 1.8 weeks of PNA, respectively. In the multivariate analysis, an older GA, a longer duration of mechanical ventilation, and a lower birth weight were correlated with a longer time between preterm birth and ROP detection (p < 0.0001, p < 0.0001, and p = 0.0359, respectively). Conclusion: The first examination for ROP screening should be individualized to fit the first screening examination as closely as possible to the first signs of ROP in order to avoid unnecessary examinations without missing ROP.

Published
2017
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66. Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia

Author

Nona Janikashvili, Christophe Ferrand, V. Leguy, Philippe Saas, Sabine Berthier, Denis Caillot, Laurent Martin, Sylvain Audia, Marc Michel, Bruno Salles, Pablo Ortega-Deballon, Bernard Bonnotte, Bernard Lorcerie, Marion Ciudad, Agnès Soudry-Faure, Nicolas Larmonier, Maxime Samson, Malika Trad, Matthieu Mahévas, Bertrand Godeau, Famky Seaphanh, Alexandrine Gautheron, and Olivier Facy

Subjects
Adult, Male, Immunology, Drug Resistance, Spleen, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Real-Time Polymerase Chain Reaction, Biochemistry, Pathogenesis, Antibodies, Monoclonal, Murine-Derived, Young Adult, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Immunologic Factors, Cytotoxic T cell, Aged, Aged, 80 and over, Purpura, Thrombocytopenic, Idiopathic, biology, business.industry, Cell Biology, Hematology, T lymphocyte, Middle Aged, Immunohistochemistry, medicine.anatomical_structure, Monoclonal, biology.protein, Female, Rituximab, Antibody, business, CD8, medicine.drug
Abstract

The pathogenic role of B cells in immune thrombocytopenia (ITP) has justified the therapeutic use of anti-CD20 antibodies such as rituximab (RTX). However, 60% of ITP patients do not respond to RTX. To decipher the mechanisms implicated in the failure of RTX, and because the spleen plays a well-recognized role in ITP pathogenesis, 12 spleens from ITP patients who had been nonresponders to RTX therapy were compared with 11 spleens from RTX-untreated ITP patients and 9 controls. We here demonstrate that in RTX-nonresponder ITP patients, preferential Th1 and Tc1 T lymphocyte polarizations occur, associated with an increase in splenic effector memory CD8(+) T-cell frequency. Moreover, in the RTX- nonresponder patient group, the CD8(+) T-cell repertoire displays a restricted pattern. In the blood, the phenotype of CD8(+) T cells before and after RTX treatment is not modified in responders or nonresponders. Altogether, these results demonstrate for the first time an activation of splenic CD8(+) T cells in ITP patients who did not respond to RTX and suggest their involvement in platelet destruction in these patients.

Published
2013
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67. Efficacy of transcranial direct current stimulation (tDCS) in reducing consumption in patients with alcohol use disorders: study protocol for a randomized controlled trial

Author

Nicolas Abello, Foroogh Sabsevari, Jean-Christophe Chauvet-Gelinier, Emilie Blaise, Eddy Ponavoy, Vincent Meille, Agnès Soudry-Faure, Bernard Bonin, Coralie Allard, Maud Carpentier, Lysiane Jonval, and Benoit Trojak

Subjects
Male, Time Factors, medicine.medical_treatment, Medicine (miscellaneous), Craving, Alcohol use disorder, Transcranial Direct Current Stimulation, law.invention, Study Protocol, Cognition, 0302 clinical medicine, Clinical Protocols, Randomized controlled trial, law, Surveys and Questionnaires, Pharmacology (medical), Deep transcranial magnetic stimulation, media_common, Transcranial direct-current stimulation, Alcohol Abstinence, Smoking, Treatment Outcome, Research Design, Female, France, medicine.symptom, Alcohol-Related Disorders, medicine.medical_specialty, Alcohol Drinking, Addiction, Context (language use), 03 medical and health sciences, Double-Blind Method, medicine, Humans, media_common.cataloged_instance, European union, Reduction, Psychiatric Status Rating Scales, business.industry, Monaco, medicine.disease, 030227 psychiatry, Affect, Brain stimulation, Quality of Life, Physical therapy, business, 030217 neurology & neurosurgery
Abstract

Approximately 15 million persons in the European Union and 10 million persons in the USA are alcohol-dependent. The global burden of disease and injury attributable to alcohol is considerable: worldwide, approximately one in 25 deaths in 2004 was caused by alcohol. At the same time, alcohol use disorders remain seriously undertreated. In this context, alternative or adjunctive therapies such as brain stimulation may play a prominent role. The early results of studies using transcranial direct current stimulation found that stimulations delivered to the dorsolateral prefrontal cortex result in a significant reduction of craving and an improvement of the decision-making processes in various additive disorders. We, therefore, hypothesize that transcranial direct current stimulation can lead to a decrease in alcohol consumption in patients suffering from alcohol use disorders. We report the protocol of a randomized, double-blind, placebo-controlled, parallel-group trial, to evaluate the efficacy of transcranial direct current stimulation on alcohol reduction in patients with an alcohol use disorder. The study will be conducted in 14 centers in France and Monaco. Altogether, 340 subjects over 18 years of age and diagnosed with an alcohol use disorder will be randomized to receive five consecutive twice-daily sessions of either active or placebo transcranial direct current stimulation. One session consists in delivering a current flow continuously (anode F4; cathode F3) twice for 13 minutes, with treatments separated by a rest interval of 20 min. Efficacy will be evaluated using the change from baseline (alcohol consumption during the 4 weeks before randomization) to 24 weeks in the total alcohol consumption and number of heavy drinking days. Secondary outcome measures will include alcohol craving, clinical and biological improvements, and the effects on mood and quality of life, as well as cognitive and safety assessments, and, for smokers, an assessment of the effects of transcranial direct current stimulation on tobacco consumption. Several studies have reported a beneficial effect of transcranial direct current stimulation on substance use disorders by reducing craving, impulsivity, and risk-taking behavior, and suggest that transcranial direct current stimulation may be a promising treatment in addiction. However, to date, no studies have included sufficiently large samples and sufficient follow-up to confirm the hypothesis. Results from this large randomized controlled trial will give a better overview of the therapeutic potential of transcranial direct current stimulation in alcohol use disorders. Clinical Trials Gov, NCT02505126 (registration date: July 15 2015).

Published
2016
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71. French Intensive Care Society, International congress - Réanimation 2016

Author

Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, 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Gisbert Mora, C, Bonnardel, E, Biais, M, Hilbert, G, Joannon, T, Marincamp, A, Chiche, J, Ferre, A, Lichtenstein, D, Meziere, G, Gonzalez, C, Hamzaoui, O, Geffriaud, T, Leleu, F, Boissier, F, Cuquemelle, E, Lim, P, Amara, R, Léger, J, Jacob, C, Bouferache, K, Ragot, C, Corradi, L, Maurice, L, Julliand, S, Deho, A, Le Bourgeois, F, Jacquot, A, Valla, F, Letois, F, Salvadori, A, Ottonello, G, Blanot, S, Montmayeur, J, Orliaguet, G, Tarmiz, K, Habas, F, Baleine, J, Lebouhellec, J, Combes, C, Chomton, M, Jouvet, P, Ranchin, B, Macher, M, Gaillot, T, Moine, M, Ageron, F, Jannel, C, Debillon, T, Wroblewski, I, Duprey, M, Jarlier, V, Luyt, C, Longval, T, Schnell, D, Padoin, C, Cohen, Y, Gaies, E, Triki, S, Klouz, A, Moussa, M, Desrumaux, F, May, F, Nguyen, J, Tiercelet, K, Fournier, J, Cherin, M, Kitzis, M, Misset, B, Mathien, C, Poidevin, A, Donatti, L, Mootien, J, Pinto, L, Egard, M, Bodur, G, Barberet, G, Ionescu, C, Ganster, F, Guiot, P, Kuteifan, K, Mpela, A, Chelly, J, Guérin, L, Persichini, R, Hullin, T, Deye, N, Aubertein, P, Paul, M, Bougouin, W, Sandroni, C, Passouant, O, Llitjos, J, Chenevier Gobeaux, C, Batteux, F, Drouet, L, Voicu, S, Henry, P, Dillinger, J, Resiere, D, Dessoy, A, Faivre, V, Damoisel, C, Stiel, L, Galoisy, A, Mauvieux, L, Zobairi, F, Angles Cano, E, Piau, C, Jeannet, R, Feuillard, J, Jolly, L, Boufenzer, A, Carrasco, K, Derive, M, Merdji, H, Belaidouni, N, Toubiana, J, L'Hermitte, Y, Woimant, F, Oppenheim, C, Couvreur, C, Dolveck, F, Devriese, M, Dupeyrat, S, Ray, P, Lefevre, G, Fartoukh, M, Roothaer, N, Carpentier, A, Vaniet, F, Maisonneuve, A, Wiel, E, Canu, S, Hammad, E, Antonini, F, Poirier, M, Vigne, C, Haddam, M, Alingrin, J, Dangers, L, Mangiapan, G, Huet, I, Dhalluin, X, Bautin, N, Quiot, J, De Vecchi, C, Chenivesse, C, Smaoui, M, El Alami, E, Weiss, N, Mochel, F, Galanaud, D, Puybasset, L, Lodey, M, Guiller, E, Vuillaume, C, De Pasquale, F, Demonet, J, Sinnah, F, Dalloz, M, D'Ortho, M, Rouvel Tallec, A, Couret, D, Catan, A, Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, C, Rooze, S, Moullet, C, Henin, A, Ettori, F, Zemmour, C, Boher, J, Feltry, A, Ben, S, Audibert, J, Conia, A, Gontier, O, Hamrouni, M, Lherm, T, Ouchenir, A, Rétif, J, Proudhom, A, Lagardere, C, Tissot, S, Kalfon, P, Sacre, L, Villa, A, Khadija, A, Garnier, R, Vasset, B, Heinzelman, A, Jouffroy, R, Durand, E, Compagnon, P, Jebri, A, Legout, C, Castot Villepelet, A, Valade, S, Lesieur, O, Delmas, B, Visseaux, B, Cohen, J, Nguyen, L, Morbieu, C, Burdet, C, Lescure, F, Armand Lefevre, L, Yazdanpanah, Y, Houhou Fidouh, N, Cazaux, M, Goff Jérôme, L, Meignin, V, Boutboul, D, Rispail, P, Besnard, N, Ceballos, P, Stoclin, A, Rotolo, F, Wartelle, M, Hicheri, Y, Maillet, S, Chachaty, E, Pignon, J, Bialais, E, Julie, D, Paoloni, L, Wittebolle, X, Hickmann, C, Castanares Zapatero, D, Tordeur, A, Colmant, L, Wittebole, X, Tirone, G, Laterre, P, Ducroux, L, Kemlin, C, Moulton, E, Rosso, C, Le Neindre, A, Mongodi, S, Bouhemad, B, Rodrigues, J, Botteau, C, Waroquier, F, Christiaens, K, Vantrimpont, F, Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE

Abstract

Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study

Published
2016

72. Diagnostic value of nail examination in Hailey-Hailey disease

Author

Blandine Bel, Agnès Soudry-Faure, and Pierre Vabres

Subjects
Observer Variation, Pathology, medicine.medical_specialty, integumentary system, Light, Pemphigus, Benign Familial, business.industry, Dermoscopy, Dermatology, Nail plate, medicine.disease, Sensitivity and Specificity, Pemphigus, White nail, medicine.anatomical_structure, Nails, Hailey–Hailey disease, Case-Control Studies, Nail (anatomy), Medicine, Humans, skin and connective tissue diseases, business, Observer variation
Abstract

Hailey-Hailey disease and Darier's disease are rare autosomal dominant acantholytic skin disorders. Whereas nail involvement in Darier's disease is well known, it has rarely been described in Hailey-Hailey disease and nails have even been considered to be spared [1]. Burge first reported multiple longitudinal white nail bands, which she found in 71% of patients [2]. Rare cases of nail involvement have subsequently been published [3-5]. Polarized dermoscopy appears useful for nail plate examination [...]

Published
2014

73. Comparison of heparin to citrate as a catheter locking solution for non-tunneled central venous hemodialysis catheters in patients requiring renal replacement therapy for acute renal failure (VERROU-REA study): study protocol for a randomized controlled trial

Author

Christine Binquet, Rémi Bruyère, Agnès Soudry-Faure, Abdelouaid Nadji, Gilles Capellier, Saber Barbar, Jean-Pierre Quenot, Maria Yannaraki, Stephane Torner, and Gilles Blasco

Subjects
Catheter Obstruction, medicine.medical_specialty, Catheterization, Central Venous, Time Factors, medicine.medical_treatment, Hemodialysis Catheter, Medicine (miscellaneous), urologic and male genital diseases, Hospitals, University, Study Protocol, Acute renal failure, Clinical Protocols, Double-Blind Method, Renal Dialysis, Citrate lock, Intensive care, Upper Extremity Deep Vein Thrombosis, Prohibitins, medicine, Central Venous Catheters, Humans, Pharmacology (medical), Heparin lock, Renal replacement therapy, Citrates, Prospective Studies, Contraindication, business.industry, Heparin, Acute kidney injury, Anticoagulants, Equipment Design, Acute Kidney Injury, medicine.disease, female genital diseases and pregnancy complications, Surgery, Catheter, Intensive Care Units, Treatment Outcome, Research Design, Hemodialysis, France, Critically ill patient, business, Catheter lock
Abstract

Background The incidence of acute kidney injury (AKI) is estimated at 10 to 20% in patients admitted to intensive care units (ICU) and often requires renal replacement therapy (RRT). ICU mortality in AKI patients can exceed 50%. Venous catheters are the preferred vascular access method for AKI patients requiring RRT, but carry a risk of catheter thrombosis or infection. Catheter lock solutions are commonly used to prevent such complications. Heparin and citrate locks are both widely used for tunneled, long-term catheters, but few studies have compared citrate versus heparin for patients with short-term, non-tunneled catheters. We aim to compare citrate 4% catheter lock solution versus heparin in terms of event-free survival of the first non-tunneled hemodialysis catheter inserted in ICU patients with AKI requiring RRT. Secondary objectives are the rate of fibrinolysis, incidence of catheter thrombosis and catheter-related infection per 1,000 catheter days, length of stay in ICU and in-hospital and 28-day mortality. Methods/Design The VERROU-REA study is a randomized, prospective, multicenter, double-blind, parallel-group, controlled superiority study carried out in the medical, surgical and nephrological ICUs of two large university hospitals in eastern France. A catheter lock solution composed of trisodium citrate at 4% will be compared to unfractionated heparin at a concentration of 5,000 IU/mL. All consecutive adult patients with AKI requiring extracorporeal RRT, and in whom a first non-tunneled catheter is to be inserted by the jugular or femoral approach, will be eligible. Catheters inserted by the subclavian approach, patients with acute liver failure, thrombopenia or contraindication to systemic anticoagulation will be excluded. Patients will be followed up daily in accordance with standard practices for RRT until death or discharge. Discussion Data is scarce regarding the use of non-tunneled catheters in the ICU setting in patients with AKI. This study will provide an evidence base for recommendations regarding the use of anticoagulant catheter locks for the prevention of dysfunction in non-tunneled hemodialysis catheters in patients with AKI in critical or intensive care. Trial registration Registered with Clinicaltrials.gov (registration number: NCT01962116) on 27 August 2013.

Published
2014

76. Efficacy of transcranial direct current stimulation (tDCS) in reducing consumption in patients with alcohol use disorders: study protocol for a randomized controlled trial

Author

Trojak, Benoit, primary, Soudry-Faure, Agnès, additional, Abello, Nicolas, additional, Carpentier, Maud, additional, Jonval, Lysiane, additional, Allard, Coralie, additional, Sabsevari, Foroogh, additional, Blaise, Emilie, additional, Ponavoy, Eddy, additional, Bonin, Bernard, additional, Meille, Vincent, additional, and Chauvet-Gelinier, Jean-Christophe, additional

Published
2016
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78. Screening for Retinopathy of Prematurity: Insight into Optimizing Screening.

Author

Pallot, Charlotte, Soudry Faure, Agnès, Charvy, Camille, Ternoy, Ninon, Langlet Muteau, Claire, Acar, Niyazi, Bron, Alain M., Speeg Schatz, Claude, and Creuzot-Garcher, Catherine

Subjects
*RETROLENTAL fibroplasia, *MEDICAL screening, *PREMATURE labor, *GESTATIONAL age, *EYE examination, *DIAGNOSIS
Abstract

Purpose: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening. Methods: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera. Population and follow-up characteristics were recorded. Results: Among the 1,266 preterm infants observed, 795 were retained for analysis. One hundred seventy-four (21.6%) cases of ROP were detected with the first examination performed at 32.3 ± 1.6 weeks of postmenstrual age (PMA) and 5.4 ± 1.0 weeks of postnatal age (PNA). The first signs of ROP were detected at 34.0 ± 1.9 weeks of PMA and 7.2 ± 1.8 weeks of PNA, respectively. In the multivariate analysis, an older GA, a longer duration of mechanical ventilation, and a lower birth weight were correlated with a longer time between preterm birth and ROP detection (p < 0.0001, p < 0.0001, and p = 0.0359, respectively). Conclusion: The first examination for ROP screening should be individualized to fit the first screening examination as closely as possible to the first signs of ROP in order to avoid unnecessary examinations without missing ROP. [ABSTRACT FROM AUTHOR]

Published
2018
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80. Comparison of heparin to citrate as a catheter locking solution for non-tunneled central venous hemodialysis catheters in patients requiring renal replacement therapy for acute renal failure (VERROU-REA study): study protocol for a randomized controlled trial

Author

Bruyère, Rémi, primary, Soudry-Faure, Agnès, additional, Capellier, Gilles, additional, Binquet, Christine, additional, Nadji, Abdelouaid, additional, Torner, Stephane, additional, Blasco, Gilles, additional, Yannaraki, Maria, additional, Barbar, Saber Davide, additional, and Quenot, Jean-Pierre, additional

Published
2014
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81. Oral water ingestion in the treatment of shock patients: a prospective randomized study.

Author

Guinot, Pierre-Grégoire, Nguyen, Maxime, Duclos, Valerian, Soudry-Faure, Agnes, Bouhemad, Belaid, The Water Study Group, Berthoud, Vivien, Ellouze, Omar, Radhouani, Mohamed, Constandache, Tiberiu, Grosjean, Sandrine, Bartamian, Loic, Martin, Audrey, Rafrafi, Emel, and Nowobilski, Nicolas

Subjects
SHOCK therapy, WATER purification, CENTRAL venous pressure, LONGITUDINAL method
Published
2020
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82. Preferential splenic CD8+T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia

Author

Audia, Sylvain, Samson, Maxime, Mahévas, Matthieu, Ferrand, Christophe, Trad, Malika, Ciudad, Marion, Gautheron, Alexandrine, Seaphanh, Famky, Leguy, Vanessa, Berthier, Sabine, Salles, Bruno, Martin, Laurent, Lorcerie, Bernard, Ortega-Deballon, Pablo, Facy, Olivier, Caillot, Denis, Soudry-Faure, Agnès, Michel, Marc, Godeau, Bertrand, Larmonier, Nicolas, Saas, Philippe, Janikashvili, Nona, and Bonnotte, Bernard

Abstract

The pathogenic role of B cells in immune thrombocytopenia (ITP) has justified the therapeutic use of anti-CD20 antibodies such as rituximab (RTX). However, 60% of ITP patients do not respond to RTX. To decipher the mechanisms implicated in the failure of RTX, and because the spleen plays a well-recognized role in ITP pathogenesis, 12 spleens from ITP patients who had been nonresponders to RTX therapy were compared with 11 spleens from RTX-untreated ITP patients and 9 controls. We here demonstrate that in RTX-nonresponder ITP patients, preferential Th1 and Tc1 T lymphocyte polarizations occur, associated with an increase in splenic effector memory CD8+T-cell frequency. Moreover, in the RTX- nonresponder patient group, the CD8+T-cell repertoire displays a restricted pattern. In the blood, the phenotype of CD8+T cells before and after RTX treatment is not modified in responders or nonresponders. Altogether, these results demonstrate for the first time an activation of splenic CD8+T cells in ITP patients who did not respond to RTX and suggest their involvement in platelet destruction in these patients.

Published
2013
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83. Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia.

Author

Audia, Sylvain, Samson, Maxime, Mahevas, Matthieu, Ferrand, Christophe, Trad, Malika, Ciudad, Marion, Gautheron, Alexandrine, Seaphanh, Famky, Leguy, Vanessa, Berthier, Sabine, Salles, Bruno, Martin, Laurent, Lorcerie, Bernard, Ortega-Deballon, Pablo, Facy, Olivier, Caillot, Denis, Soudry-Faure, Agnes, Michel, Marc, Godeau, Bertrand, and Larmonier, Nicolas

Subjects
*THROMBOCYTOPENIA, *CELLULAR therapy, *BLOOD platelet disorders, *T cells, *HEMATOPOIETIC system
Abstract

The pathogenic role of B cells in immune thrombocytopenia (ITP) has justified the therapeutic use of anti-CD20 antibodies such as rituximab (RTX). However, 60% of ITP patients do not respond to RTX. To decipher the mechanisms implicated in the failure of RTX, and because the spleen plays a well-recognized role in ITP pathogenesis, 12 spleens from ITP patients who had been nonresponders to RTX therapy were compared with 11 spleens from RTX-untreated ITP patients and 9 controls. We here demonstrate that in RTX-nonresponder ITP patients, preferential Th1 and Tc1 T lymphocyte polarizations occur, associated with an increase in splenic effector memory CD8+ T-cell frequency. Moreover, in the RTX- nonresponder patient group, the CD8+ T-cell repertoire displays a restricted pattern. In the blood, the phenotype of CD8+ T cells before and after RTX treatment is not modified in responders or nonresponders. Altogether, these results demonstrate for the first time an activation of splenic CD8+ T cells in ITP patients who did not respond to RTX and suggest their involvement in platelet destruction in these patients [ABSTRACT FROM AUTHOR]

Published
2013
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84. Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization.

Author

Ciudad M, Ouandji S, Lamarthée B, Cladière C, Ghesquière T, Nivet M, Thébault M, Boidot R, Soudry-Faure A, Chevrier S, Richard C, Maillet T, Maurier F, Greigert H, Genet C, Ramon A, Trad M, Predan V, Saas P, Samson M, Bonnotte B, and Audia S

Subjects
Animals, Humans, Tumor Necrosis Factor-alpha, Forkhead Transcription Factors metabolism, Th17 Cells, T-Lymphocytes, Regulatory, Anemia, Hemolytic, Autoimmune, Aminopyridines, Morpholines, Pyrimidines
Abstract

Warm autoimmune hemolytic anemia (wAIHA) is a rare acquired autoimmune disease mediated by antibodies targeting red blood cells. The involvement of CD4 T-helper cells has been scarcely explored, with most findings extrapolated from animal models. Here, we performed quantification of both effector T lymphocytes (Teff) and regulatory T cells (Treg), associated with functional and transcriptomic analyses of Treg in human wAIHA. We observed a shift of Teff toward a Th17 polarization concordant with an increase in serum interleukin-17 concentration that correlates with red blood cell destruction parameters, namely lactate dehydrogenase and bilirubin levels. A decrease in circulating Treg, notably effector Treg, associated with a functional deficiency, as represented by their decrease capability to inhibit Teff proliferation, were also observed. Treg deficiency was associated with a reduced expression of Foxp3, the master transcription factor known to maintain the Treg phenotype stability and suppressive functions. Transcriptomic profiling of Treg revealed activation of the tumor necrosis facto (TNF)-α pathway, which was linked to increased serum TNF-α concentrations that were twice as high as in controls. Treg transcriptomic profiling also suggested that post-translational mechanisms possibly accounted for Foxp3 downregulation and Treg dysfunctions. Since TNF-α participates in the rupture of immune tolerance during wAIHA, its inhibition could be of interest. To this end, the effects of fostamatinib, a SYK inhibitor, were investigated in vitro, and we showed that besides the inhibition of erythrocyte phagocytosis by monocytes, fostamatinib is also able to dampen TNF-α production, thus appearing as a promising multitargeting therapy in wAIHA (clinicaltrials gov. Identifier: NCT02158195).

Published
2024
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85. [A caregiver-person with schizophrenia partnership to improve oral health education]

Author

Rat C, Peteuil A, Reynaud M, Millot I, Carpentier M, Soudry-Faure A, and Denis F

Subjects
Feasibility Studies, Focus Groups, France, Humans, Caregivers psychology, Oral Health education, Patient Education as Topic organization & administration, Schizophrenia therapy
Abstract

Introduction: Poor oral health in persons with schizophrenia is a major public health issue affecting 600,000 people in France. The aim of this article was to present the different stages in the development of a specific oral health educational program for persons with schizophrenia. It takes into account experimental knowledge of these persons and presents the results of the feasibility study., Patients and Method: The focus group method was applied to a group of health professionals and users to highlight an exploratory corpus in order to develop an oral health educational program. An expert group including persons with schizophrenia among others validated the fields and tools of this program. A feasibility study was then conducted in a control group of 7 persons with schizophrenia., Results: Altogether, 26 persons participated in this feasibility study. The main fields investigated by the expert group aimed to promote personal responsibility for one’s health, to improve access to the healthcare system and to promote the global management of health. The feasibility study showed the ability of this program to change persons with schizophrenia representations and knowledge of this health problem. Most educational tools were considered relevant., Conclusion: An oral health educational program was built as part of a caregiver-persons with schizophrenia partnership and showed its feasibility. A multicentric randomized trial is currently ongoing to assess the efficacy of this program with a high level of proof.

Published
2019
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86. [Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network].

Author

Quantin C, Collin C, Frérot M, Besson J, Cottenet J, Corneloup M, Soudry-Faure A, Mariet AS, and Roussot A

Subjects
Adult, Antipsychotic Agents therapeutic use, Critical Pathways statistics & numerical data, France epidemiology, Hospitalization statistics & numerical data, Humans, Outpatients statistics & numerical data, Schizophrenia therapy, Algorithms, Databases, Factual statistics & numerical data, Information Services statistics & numerical data, Medical Records Systems, Computerized statistics & numerical data, National Health Programs statistics & numerical data, Schizophrenia epidemiology
Abstract

Background: The aim of the REDSIAM network is to foster communication between users of French medico-administrative databases and to validate and promote analysis methods suitable for the data. Within this network, the working group "Mental and behavioral disorders" took an interest in algorithms to identify adult schizophrenia in the SNIIRAM database and inventoried identification criteria for patients with schizophrenia in these databases., Methods: The methodology was based on interviews with nine experts in schizophrenia concerning the procedures they use to identify patients with schizophrenia disorders in databases. The interviews were based on a questionnaire and conducted by telephone., Results: The synthesis of the interviews showed that the SNIIRAM contains various tables which allow coders to identify patients suffering from schizophrenia: chronic disease status, drugs and hospitalizations. Taken separately, these criteria were not sufficient to recognize patients with schizophrenia, an algorithm should be based on all of them. Apparently, only one-third of people living with schizophrenia benefit from the longstanding disease status. Not all patients are hospitalized, and coding for diagnoses at the hospitalization, notably for short stays in medicine, surgery or obstetrics departments, is not exhaustive. As for treatment with antipsychotics, it is not specific enough as such treatments are also prescribed to patients with bipolar disorders, or even other disorders. It seems appropriate to combine these complementary criteria, while keeping in mind out-patient care (every year 80,000 patients are seen exclusively in an outpatient setting), even if these data are difficult to link with other information. Finally, the experts made three propositions for selection algorithms of patients with schizophrenia., Conclusion: Patients with schizophrenia can be relatively accurately identified using SNIIRAM data. Different combinations of the selected criteria must be used depending on the objectives and they must be related to an appropriate length of time., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Published
2017
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