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Summary A 73 year old female presented with progressive hypoproteinaemic oedema which was resistant to treatment. The cause was not established until post-mortem, when it was found that she had angiotropic large cell lymphoma involving the vessels of the large intestine with mucosal ulceration. To our knowledge, this is the first report of angiotropic large cell lymphoma, which usually presents with neurological and skin involvement, presenting with protein-losing enteropathy.

Pathological mineralization may complicate a broad spectrum of clinical conditions and take such diverse forms as urinary-stones, dental calculus, salivary calculi, biliary calculi, pancreatic stones, crystal deposits in joints, and various forms of ectopic calcification (Smith, this volume). It was decided, mainly because of the structure and interests of the group, to discuss only four of these in depth. These were considered under two main headings: (a) dental and urinary calculus formation, and (b) abnormal tissue mineralization (with emphasis on pseudogout and ectopic calcification).

We determined quantitative nucleation and growth kinetics of calcium oxalate in the presence of various combinations of urine constituents, using a continuous mixed suspension mixed product removal crystallizer and a Coulter counter. Nucleation rates of calcium oxalate from the pure component system were approximately an order of magnitude higher than those from an artificial urine. The presence of citrate inhibited nucleation rates under high conditions. The ions Na+, K+, NH4+, Cl-, and SO42- did not affect the overall kinetics in the synthetic urine. Di- and tri-hydrate products were formed, except when crystallizing from pure components, when only the thermodynamically stable monohydrate was observed.

In this article, Mr Garside gives a procedure for comparing all sub‐sets in multiple regression analysis and thereby obtaining the best sub‐set of a given size in the sense of the minimum residual sum of squares. The author also points out that this is a special case of a more general problem.