Search

Your search keyword '"A Hartkopf"' showing total 3,590 results
Start Over Author "A Hartkopf"

Refine your results

more »

more »

more »

more »

more »

more »
3,590 results on '"A Hartkopf"'

52. Speckle Interferometry at the U.S. Naval Observatory. XXIII

Author

Mason, Brian D., Hartkopf, William I., Urban, Sean E., and Josties, Jordan D.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The results of 3,989 intensified CCD observations of double stars, made with the 26-inch refractor of the U.S. Naval Observatory, are presented. Each observation of a system represents a combination of over two thousand short-exposure images. These observations are averaged into 1,911 mean relative positions and range in separation from 0.289 to 128.638, with a median separation of 8.669. Four orbits are improved. This is the 23rd in this series of papers and covers the period 4 January 2017 through 13 September 2017., Comment: 73 pages, 8 tables, 2 figures

Published
2018
Full Text
View/download PDF

53. Speckle interferometry at SOAR in 2016 and 2017

Author

Tokovinin, Andrei, Mason, Brian D., Hartkopf, William I., Mendez, Rene A., and Horch, Elliott P.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The results of speckle interferometric observations at the 4.1 m SOAR telescope in 2016 and 2017 are given, totaling 2483 measurements of 1570 resolved pairs and 609 non-resolutions. We describe briefly recent changes in the instrument and observing method and quantify the accuracy of the pixel scale and position angle calibration. Comments are given on 44 pairs resolved here for the first time. Orbital motion of the newly resolved subsystem BU~83 Aa,Ab roughly agrees with its 36 year astrometric orbit proposed by J.~Dommanget. Most Tycho binaries examined here turned out to be spurious., Comment: Accepted by AJ. 11 pages, 5 figures. Electronic tables 3,4 are available from the 1st author

Published
2018
Full Text
View/download PDF

54. Distances of Dwarf Carbon Stars

Author

Harris, Hugh C., Dahn, Conard C., Subasavage, John P., Munn, Jeffrey A., Canzian, Blaise J., Levine, Stephen E., Monet, Alice B., Pier, Jeffrey R., Stone, Ronald C., Tilleman, Trudy M., and Hartkopf, William I.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Parallaxes are presented for a sample of 20 nearby dwarf carbon stars. The inferred luminosities cover almost two orders of magnitude. Their absolute magnitudes and tangential velocities confirm prior expectations that some originate in the Galactic disk, although more than half of this sample are halo stars. Three stars are found to be astrometric binaries, and orbital elements are determined; their semimajor axes are 1 -- 3 AU, consistent with the size of an AGB mass-transfer donor star., Comment: 9 pages, 5 figures, accepted by Astronomical Journal

Published
2018
Full Text
View/download PDF

55. Speckle Interferometry of Red Dwarf Stars

Author

Mason, Brian D., Hartkopf, William I., Miles, Korie N., Subasavage, John P., Raghavan, Deepak, and Henry, Todd J.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We report high resolution optical speckle observations of 336 M dwarfs which result in 113 measurements of relative position of 80 systems and 256 other stars with no indications of duplicity. These are the first measurements for two of the systems. We also present the earliest measures of relative position for 17 others. We include orbits for six of the systems, two revised and four reported for the first time. For one of the systems with a new orbit, G 161-7, we determine masses of 0.156 +/- 0.011 and 0.1175 +/-0.0079 \msun for the A and B components, respectively. All six of these new calculated orbits have short periods between five and thirty-eight years and hold the promise of deriving accurate masses in the near future. For many other pairs we can establish their nature as physical or chance alignment depending on their relative motion. Of the 80 systems, 32 have calculated orbits, 25 others are physical pairs, 4 are optical pairs and 19 are currently unknown., Comment: 29 pages, 2 figures, 7 tables

Published
2018
Full Text
View/download PDF

57. Impact of maternal emotional state during pregnancy on fetal heart rate variability

Author

Lorenzo Semeia, Ilena Bauer, Katrin Sippel, Julia Hartkopf, Nora K. Schaal, and Hubert Preissl

Subjects
Maternal stress, Maternal emotional state, Fetal heart rate variability, Fetal autonomous nervous system, Fetal magnetocardiography, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Psychology, BF1-990
Abstract

Background: The fetal autonomic nervous system (ANS) is believed to be negatively affected by maternal adverse emotional states. In this study, we evaluated how depression, anxiety and stress during pregnancy are related to fetal heart rate variability (HRV) as recorded with magnetocardiography (MCG). We also considered metabolic factors such as maternal adiposity and circulating levels of cortisol during gestation. Furthermore, we followed up these fetuses after birth, recording HRV and saliva levels of cortisol in these infants to establish any effects postpartum. Methods: We calculated HRV in spontaneous MCG recordings from 32 healthy fetuses between 32 and 38 weeks of gestational age. Maternal emotional state was assessed using standardized questionnaires about anxiety, depression and stress. An overall indicator of maternal well-being was calculated by z-scoring each individual questionnaire and summation. We used a median split to divide the group into high and low z-scores (HZS and LZS), respectively. Standard HRV measures were determined in the time and frequency domain. T-test analyses were performed between LZS and HZS, with the HRV and the metabolic measures as the dependent variables. Results: We found an impaired HRV in the HZS group both during pregnancy and after birth. No differences were observed between LZS and HZS for metabolic factors. Depression and anxiety symptoms seem to affect HRV differently. No relationship was found between maternal and infant cortisol levels. Conclusions: On the basis of our results on different HRV parameters, we propose that maternal emotional state might affect the development of the fetal nervous system in utero.

Published
2023
Full Text
View/download PDF

58. Occurrence and characteristics of patients with de novo advanced breast cancer according to patient and tumor characteristics – A retrospective analysis of a real world registry

Author

Müller, Volkmar, Hein, Alexander, Hartkopf, Andreas D., Fasching, Peter A., Kolberg, Hans-Christian, Hadji, Peyman, Tesch, Hans, Häberle, Lothar, Ettl, Johannes, Lüftner, Diana, Wallwiener, Markus, Beckmann, Matthias W., Schneeweiss, Andreas, Belleville, Erik, Uhrig, Sabrina, Wimberger, Pauline, Hielscher, Carsten, Meyer, Julia, Wurmthaler, Lena A., Kurbacher, Christian M., Wuerstlein, Rachel, Untch, Michael, Janni, Wolfgang, Taran, Florin-Andrei, Lux, Michael P., Wallwiener, Diethelm, Brucker, Sara Y., Fehm, Tanja N., and Michel, Laura L.

Published
2022
Full Text
View/download PDF

59. The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer—a pooled analysis of the randomised clinical trials PlanB and SUCCESS C

Author

de Gregorio, Amelie, Janni, Wolfgang, Friedl, Thomas W. P., Nitz, Ulrike, Rack, Brigitte, Schneeweiss, Andreas, Kates, Ronald, Fehm, Tanja, Kreipe, Hans, Christgen, Matthias, Kümmel, Sherko, Trapp, Elisabeth, Wuerstlein, Rachel, Hartkopf, Andreas, Clemens, Michael, Reimer, Toralf, Häberle, Lothar, Fasching, Peter A., Gluz, Oleg, and Harbeck, Nadia

Published
2022
Full Text
View/download PDF

62. Speckle Interferometry at the U.S. Naval Observatory. XXII

Author

Mason, Brian D. and Hartkopf, William I.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The results of 4,747 intensified CCD observations of double stars, made with the 26-inch refractor of the U.S. Naval Observatory, are presented. Each observation of a system represents a combination of over two thousand short-exposure images. These observations are averaged into 2,667 mean relative positions and range in separation from 0.328" to 95.9", with a median separation of 8.673". Four orbits are improved. This is the 22nd in this series of papers and covers the period 4 January 2016 through 29 December 2016., Comment: 91 pages, 8 tables, 1 figure

Published
2017
Full Text
View/download PDF

63. Binary Star Orbits. V. The Nearby White Dwarf - Red Dwarf pair 40 Eri BC

Author

Mason, Brian D., Hartkopf, William I., and Miles, Korie N.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

A new relative orbit solution with new dynamical masses is determined for the nearby white dwarf - red dwarf pair 40 Eri BC. The period is 230.09+/-0.68y. It is predicted to close slowly over the next half-century getting as close as 1.32" in early 2066. We determine masses of 0.575+/-0.018 $m_\odot$ for the white dwarf and 0.2041+/-0.0064 $m_\odot$ for the red dwarf companion. The inconsistency of the masses determined by gravitational redshift and dynamical techniques, due to a premature orbit calculation, no longer exists., Comment: 25 pages, 5 tables, 1 figure

Published
2017
Full Text
View/download PDF

64. Update Mammakarzinom 2024 Teil 1 – Expertenmeinungen zu Brustkrebs in fortgeschrittenen Krankheitsstadien.

Author

Würstlein, Rachel, Kolberg, Hans-Christian, Hartkopf, Andreas D., Fehm, Tanja N., Welslau, Manfred, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Witzel, Isabell, Thomssen, Christoph, Krückel, Annika, Belleville, Erik, Lüftner, Diana, Untch, Michael, Thill, Marc, Hörner, Manuel, Tesch, Hans, Ditsch, Nina, Lux, Michael P., and Aktas, Bahriye

Published
2024
Full Text
View/download PDF

65. Breast Cancer and Mental Health: Incidence and Influencing Factors—A Claims Data Analysis from Germany.

Author

von Au, Alexandra, Dannehl, Dominik, Dijkstra, Tjeerd Maarten Hein, Gutsfeld, Raphael, Scholz, Anna Sophie, Hassdenteufel, Kathrin, Hahn, Markus, Hawighorst-Knapstein, Sabine, Isaksson, Alexandra, Chaudhuri, Ariane, Bauer, Armin, Wallwiener, Markus, Wallwiener, Diethelm, Brucker, Sara Yvonne, Hartkopf, Andreas Daniel, and Wallwiener, Stephanie

Subjects
MENTAL illness risk factors, PSYCHIATRIC epidemiology, BREAST tumor treatment, RISK assessment, MAMMAPLASTY, RESEARCH funding, BREAST tumors, RETROSPECTIVE studies, ANXIETY, DESCRIPTIVE statistics, ODDS ratio, METASTASIS, ADJUSTMENT disorders, HORMONE therapy, CASE-control method, CONFIDENCE intervals, MASTECTOMY, MENTAL depression
Abstract

Simple Summary: This study investigates how frequently breast cancer patients develop mental disorders compared to a control group without breast cancer. We analyzed data from over 11,000 breast cancer patients and nearly 32,000 healthy controls, finding that breast cancer patients were significantly more likely to suffer from mental disorders. Anxiety disorders, hypochondria, adjustment disorders, and depression were particularly common. This study also examined factors such as the type of therapy: endocrine therapy and breast reconstruction were strongly associated with psychological distress, and simple-mastectomy patients showed the lowest rates of mental illness. This work is of particular importance because it highlights how significantly the mental health of breast cancer patients can deteriorate due to their diagnosis and treatment. Thus, psychological counseling should be part of every treatment for breast cancer, especially when endocrine therapy is recommended. The practice of recommending breast reconstruction after mastectomy should be reconsidered, as it could have a negative effect on mental health. Background/Objectives: With breast cancer (BC) survival improving due to optimized therapy, enhancing quality of life has become increasingly important. Both diagnosis and treatment, with their potential side effects, pose risks to mental well-being. Our study aimed to analyze the incidence and potential risk factors for mental disorders in BC patients. Methods: This retrospective analysis used claims data from AOK Baden-Wuerttemberg, including 11,553 BC patients diagnosed via ICD code C50 between 2010 and 2020 and 31,944 age-matched controls. Patients with mental disorders in the 12 months prior to diagnosis were excluded. Mental disorders were categorized into eight groups based on ICD codes: anxiety, obsessive compulsive disorder, adjustment disorder, dissociative disorder, hypochondriac disorder, affective disorder, mania, and other neuroses. Results: Mental disorders were significantly more common in BC patients than in controls (64.2% vs. 38.1%, p < 0.01, OR 2.91, 95%CI [2.79, 3.04]). In particular, hypochondriac, anxiety, affective, and adjustment disorders occurred significantly more often in BC patients. No differences were found for mania, bipolar disease, other neuroses, obsessive compulsive-, or dissociative disorders. Furthermore, endocrine therapy was associated with psychological comorbidities (OR 1.69, p < 0.001, 95%CI [1.53, 1.86]), while primarily metastasized patients (stage C) had a lower risk than adjuvant patients in stage A (OR 0.55, p < 0.0001, 95%CI [0.49, 0.61]). Regarding surgical treatment, mastectomy patients showed lower rates of mental illnesses (61.2%) than those with breast-conserving treatment (71.6%), or especially breast reconstruction (78.4%, p < 0.01). Breast reconstruction was also associated with more hypochondriac (p < 0.01) and adjustment disorders (p < 0.01). Conclusions: So, BC patients experience significantly more mental disorders than controls, particularly when treated with endocrine therapy and breast reconstructive surgery. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

66. Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer.

Author

Zimmer, Philipp, Esser, Tobias, Lueftner, Diana, Schuetz, Florian, Baumann, Freerk T., Rody, Achim, Schneeweiss, Andreas, Hartkopf, Andreas D., Decker, Thomas, Uleer, Christoph, Stoetzer, Oliver J., Foerster, Frank, Schmidt, Marcus, Mundhenke, Christoph, Steindorf, Karen, Tesch, Hans, Jackisch, Christian, Fischer, Thomas, Hanson, Sven, and Kreuzeder, Julia

Subjects
METASTATIC breast cancer, PHYSICAL activity, CANCER patients, HORMONE receptor positive breast cancer, FATIGUE (Physiology), HORMONE receptors
Abstract

Background : Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–control and cohort studies have focused on associations between overall leisure time physical activity and survival of women with breast cancer in general. Methods: In this multicenter prospective cohort study, conducted in Germany between 30th August 2012 to 29th December 2017, we investigated general physical activity in a homogenous sample of n = 1440 postmenopausal women with advanced (inoperable locally advanced or metastatic), hormone receptor-positive breast cancer receiving the same therapy (everolimus and exemestane). Self-reported physical activity was assessed using the Godin Leisure Time Exercise Questionnaire (GLTEQ) before and every 3 months during treatment. Participants were then classified into "active" and "insufficiently active" to screen their activity behavior the week prior to medical treatment. In addition, changes in physical activity patterns were assessed. Adjusted Cox regression analyses were performed for the activity categories to determine hazard ratios (HR). Besides progression-free survival (PFS), adverse events (AEs), QoL, and fatigue were assessed every 3 months until study termination. Results: Compared to "insufficiently active" patients, "active" individuals indicated a significantly longer PFS (HR: 0.84 [0.74; 0.984], p =.0295). No significant differences were observed for changes of physical activity behavior. Patients who reported to be "active" at baseline revealed significantly fewer AEs compared to "insufficiently" active patients. In detail, both severe and non-severe AEs occurred less frequently in the "active" patients group. In line with that, QoL and fatigue were better in physical "active" patients compared to their insufficient active counterparts at the last post-baseline assessment. Participants who remained or become active indicated less AEs, a higher QoL, and reduced fatigue levels. Conclusions: Physical activity behavior prior to medical treatment might have prognostic value in patients with advanced breast cancer in terms of extending the PFS. Moreover, physical activity before and during treatment may reduce treatment-related side effects and improve patients' QoL and fatigue. Trial registration: EUPAS9462. Registered 30th October 2012 "retrospectively registered." [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

68. Trastuzumab treatment of patients with early, HER2-positive breast cancer in 17 certified German breast cancer centers

Author

Sibert, Nora Tabea, Wesselmann, Simone, Breidenbach, Clara, Blohmer, Jens, Brückner, Barbara, Gebauer, Gerhard, dos Santos Guilherme, Marina, Hartkopf, Andreas, Lindner, Christoph, Peschel, Susanne, Rieger, Lorenz, Schad, Friedemann, Strecker, Paul, Ferencz, Julia, Dieng, Sebastian, Inwald, Elisabeth C., Kowalski, Christoph, and Ortmann, Olaf

Published
2022
Full Text
View/download PDF

71. RECONSTRUCTING KUNGURIAN (CISURALIAN, PERMIAN) TERRESTRIAL ENVIRONMENTS WITHIN A MEGACALDERA IN THE SOUTHERN ALPS (N-ITALY) USING LITHOFACIES ANALYSIS, PALYNOLOGY AND STABLE CARBON ISOTOPES

Author

Francesca Vallé, HENDRIK NOWAK, EVELYN KUSTATSCHER, SALLY ERKENS, GUIDO ROGHI, CORRADO MORELLI, KARL KRAINER, NEREO PRETO, and CHRISTOPH HARTKOPF-FRÖDER

Subjects
Early Permian, palynofacies, sporomorphs, depositional environments, sedimentology, vegetation., Geology, QE1-996.5, Paleontology, QE701-760
Abstract

During the Permian, climate experienced a change from icehouse to greenhouse conditions. Few multidisciplinary studies have investigated Kungurian (late Cisuralian) tropical terrestrial ecosystem and climate changes. Here, we apply an interdisciplinary approach to two alluvial-lacustrine successions of the Athesian Volcanic Group (Southern Alps, northern Italy) deposited in a Kungurian megacaldera during periods of volcanic quiescence. Sedimentological analysis combined with palynofacies studies allowed the reconstruction of the depositional environments. The study of sporomorph assemblages and stable organic carbon isotopes provided information on plant communities and the climate context. Two different depositional environments were present in the megacaldera: one proximal and one more distal with respect to the source, distinguished by a slightly different composition of the sediments, palynofacies and organic carbon isotopes. The plant community in the area was dominated by xeromorphic-hygromorphic taxa. The δ13Corgvalues are comparable to those of other Cisuralian continental organic matter and plants. The stable carbon isotope values show a small variability, which correlates weakly, but significantly, with the abundance of xeromorphic elements. All observations support deposition during semiarid to arid climate conditions, typical of the mid-late Cisuralian in the area.

Published
2023
Full Text
View/download PDF

72. Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Author

Rambau, Peter F, Vierkant, Robert A, Intermaggio, Maria P, Kelemen, Linda E, Goodman, Marc T, Herpel, Esther, Pharoah, Paul D, Kommoss, Stefan, Jimenez-Linan, Mercedes, Karlan, Beth Y, Gentry-Maharaj, Aleksandra, Menon, Usha, Polo, Susanna Hernando, Candido Dos Reis, Francisco J, Doherty, Jennifer Anne, Gayther, Simon A, Sharma, Raghwa, Larson, Melissa C, Harnett, Paul R, Hatfield, Emma, de Andrade, Jurandyr M, Nelson, Gregg S, Steed, Helen, Schildkraut, Joellen M, Carney, Micheal E, Høgdall, Estrid, Whittemore, Alice S, Widschwendter, Martin, Kennedy, Catherine J, Wang, Frances, Wang, Qin, Wang, Chen, Armasu, Sebastian M, Daley, Frances, Coulson, Penny, Jones, Micheal E, Anglesio, Micheal S, Chow, Christine, de Fazio, Anna, García-Closas, Montserrat, Brucker, Sara Y, Cybulski, Cezary, Harris, Holly R, Hartkopf, Andreas D, Huzarski, Tomasz, Jensen, Allan, Lubiński, Jan, Oszurek, Oleg, Benitez, Javier, Mina, Fady, Staebler, Annette, Taran, Florin Andrei, Pasternak, Jana, Talhouk, Aline, Rossing, Mary Anne, Hendley, Joy, AOCS Group, Edwards, Robert P, Fereday, Sian, Modugno, Francesmary, Ness, Roberta B, Sieh, Weiva, El-Bahrawy, Mona A, Winham, Stacey J, Lester, Jenny, Kjaer, Susanne K, Gronwald, Jacek, Sinn, Peter, Fasching, Peter A, Chang-Claude, Jenny, Moysich, Kirsten B, Bowtell, David D, Hernandez, Brenda Y, Luk, Hugh, Behrens, Sabine, Shah, Mitul, Jung, Audrey, Ghatage, Prafull, Alsop, Jennifer, Alsop, Kathryn, García-Donas, Jesús, Thompson, Pamela J, Swerdlow, Anthony J, Karpinskyj, Chloe, Cazorla-Jiménez, Alicia, García, María J, Deen, Susha, Wilkens, Lynne R, Palacios, José, Berchuck, Andrew, Koziak, Jennifer M, Brenton, James D, Cook, Linda S, Goode, Ellen L, Huntsman, David G, Ramus, Susan J, and Köbel, Martin

Subjects
AOCS Group, Ovary, Humans, Adenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Prognosis, Immunohistochemistry, Survival Rate, Adult, Aged, Middle Aged, Female, Cyclin-Dependent Kinase Inhibitor p16, RT-QPCR, immunocytochemistry, ovary, Adenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Cancer, Genetics, Ovarian Cancer, Rare Diseases, 2.1 Biological and endogenous factors
Abstract

We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ovarian carcinomas including 4334 HGSC using tissue microarrays from 24 studies participating in the Ovarian Tumor Tissue Analysis consortium. p16 expression patterns were interpreted as abnormal (either overexpression referred to as block expression or absence) or normal (heterogeneous). CDKN2A (which encodes p16) mRNA expression was also analyzed in a subset (n = 2280) mostly representing HGSC (n = 2010). Association of p16 expression with overall survival (OS) was determined within histotypes as was CDKN2A expression for HGSC only. p16 block expression was most frequent in HGSC (56%) but neither protein nor mRNA expression was associated with OS. However, relative to heterogeneous expression, block expression was associated with shorter OS in endometriosis-associated carcinomas, clear cell [hazard ratio (HR): 2.02, 95% confidence (CI) 1.47-2.77, p < 0.001] and endometrioid (HR: 1.88, 95% CI 1.30-2.75, p = 0.004), while absence was associated with shorter OS in low-grade serous carcinomas (HR: 2.95, 95% CI 1.61-5.38, p = 0.001). Absence was most frequent in mucinous carcinoma (50%), and was not associated with OS in this histotype. The prognostic value of p16 expression is histotype-specific and pattern dependent. We provide definitive evidence against an association of p16 expression with survival in ovarian HGSC as previously suggested. Block expression of p16 in clear cell and endometrioid carcinoma should be further validated as a prognostic marker, and absence in low-grade serous carcinoma justifies CDK4 inhibition.

Published
2018

73. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.

Author

Block, Matthew S, Vierkant, Robert A, Rambau, Peter F, Winham, Stacey J, Wagner, Philipp, Traficante, Nadia, Tołoczko, Aleksandra, Tiezzi, Daniel G, Taran, Florin Andrei, Sinn, Peter, Sieh, Weiva, Sharma, Raghwa, Rothstein, Joseph H, Ramón Y Cajal, Teresa, Paz-Ares, Luis, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, McGuire, Valerie, McCauley, Bryan M, Mack, Marie, Lubiński, Jan, Longacre, Teri A, Li, Zheng, Lester, Jenny, Kennedy, Catherine J, Kalli, Kimberly R, Jung, Audrey Y, Johnatty, Sharon E, Jimenez-Linan, Mercedes, Jensen, Allan, Intermaggio, Maria P, Hung, Jillian, Herpel, Esther, Hernandez, Brenda Y, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Gao, Bo, Fereday, Sian, Eilber, Ursula, Edwards, Robert P, de Sousa, Christiani B, de Andrade, Jurandyr M, Chudecka-Głaz, Anita, Chenevix-Trench, Georgia, Cazorla, Alicia, Brucker, Sara Y, Australian Ovarian Cancer Study Group, Alsop, Jennifer, Whittemore, Alice S, Steed, Helen, Staebler, Annette, Moysich, Kirsten B, Menon, Usha, Koziak, Jennifer M, Kommoss, Stefan, Kjaer, Susanne K, Kelemen, Linda E, Karlan, Beth Y, Huntsman, David G, Høgdall, Estrid, Gronwald, Jacek, Goodman, Marc T, Gilks, Blake, García, María José, Fasching, Peter A, de Fazio, Anna, Deen, Suha, Chang-Claude, Jenny, Candido Dos Reis, Francisco J, Campbell, Ian G, Brenton, James D, Bowtell, David D, Benítez, Javier, Pharoah, Paul DP, Köbel, Martin, Ramus, Susan J, and Goode, Ellen L

Subjects
Australian Ovarian Cancer Study Group, Humans, Ovarian Neoplasms, Tissue Array Analysis, Immunohistochemistry, Survival Analysis, Adult, Aged, Middle Aged, Female, Toll-Like Receptor 4, Myeloid Differentiation Factor 88, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Medical and Health Sciences
Abstract

ObjectiveTo evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival.Patients and methodsWe conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong).ResultsExpression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P

Published
2018

74. Neoadjuvant dynamic marker-adjusted personalized therapy comparing trastuzumab-deruxtecan versus pacli-/docetaxel + carboplatin + trastuzumab + pertuzumab in HER2+ early breast cancer: WSG-ADAPT-HER2-IV.

Author

Harbeck, Nadia, primary, Braun, Michael, additional, Gluz, Oleg, additional, Schmid, Peter, additional, Graeser, Monika Karla, additional, Hartkopf, Andreas D., additional, Hoffmann, Oliver, additional, Kostara, Athina, additional, Polata, Silke, additional, Volmer, Lea Louise, additional, von Schumann, Raquel, additional, Wetzig, Sarah, additional, Wiebe, Stefanie, additional, Zaiss, Matthias R., additional, Fischer, Lotta Ada, additional, Scheffen, Iris, additional, Christgen, Matthias, additional, Kreipe, Hans Heinrich, additional, Nitz, Ulrike, additional, and Kuemmel, Sherko, additional

Published
2024
Full Text
View/download PDF

75. The SURVIVE study: Liquid biopsy guided surveillance after intermediate- to high-risk early breast cancer.

Author

Pfister, Kerstin, primary, Huesmann, Sophia, additional, Friedl, Thomas W. P., additional, Fink, Angelina, additional, Mehmeti, Forca, additional, Mergel, Franziska, additional, Schäffler, Henning, additional, Heublein, Sabine, additional, Hartkopf, Andreas Daniel, additional, Mueller, Volkmar, additional, Wiesmueller, Lisa Maria, additional, Fehm, Tanja N., additional, Pantel, Klaus, additional, Rack, Brigitte, additional, and Janni, Wolfgang, additional

Published
2024
Full Text
View/download PDF

76. Multiomic factor analysis for pathologic complete response (pCR) after 12 weeks of pembrolizumab + trastuzumab + pertuzumab in HER2-enriched (HER2-E) early breast cancer (eBC) in the Keyriched-1 trial.

Author

Graeser, Monika Karla, primary, Gluz, Oleg, additional, Schmid, Peter, additional, Jozwiak, Katarzyna, additional, Feuerhake, Friedrich, additional, Volk, Valery, additional, Ulbrich-Gebauer, Daniel, additional, Biehl, Claudia, additional, Reinisch, Mattea, additional, Luedtke-Heckenkamp, Kerstin, additional, Hartkopf, Andreas D., additional, Hilpert, Felix, additional, Braun, Michael, additional, Blohmer, Jens U., additional, Christgen, Matthias, additional, Kreipe, Hans Heinrich, additional, Nitz, Ulrike, additional, Pelz, Enrico, additional, Harbeck, Nadia, additional, and Kuemmel, Sherko, additional

Published
2024
Full Text
View/download PDF

78. Update Breast Cancer 2024 Part 1 – Expert Opinion on Advanced Breast Cancer

Author

Würstlein, Rachel, additional, Kolberg, Hans-Christian, additional, Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Witzel, Isabell, additional, Thomssen, Christoph, additional, Krückel, Annika, additional, Belleville, Erik, additional, Lüftner, Diana, additional, Untch, Michael, additional, Thill, Marc, additional, Hörner, Manuel, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Taran, Florin-Andrei, additional, Wöckel, Achim, additional, Harbeck, Nadia, additional, Stickeler, Elmar, additional, Bartsch, Rupert, additional, Schneeweiss, Andreas, additional, Ettl, Johannes, additional, Krug, David, additional, and Müller, Volkmar, additional

Published
2024
Full Text
View/download PDF

79. Vergleich von Trastuzumab-Biosimilar ABP 980 mit Referenz-Trastuzumab bei der neoadjuvanten Therapie von HER2-positivem Brustkrebs – Analyse eines großen universitären Brustkrebszentrums

Author

Matovina, Sabine, additional, Engler, Tobias, additional, Volmer, Lea Louise, additional, Müller, Heike, additional, Grischke, Eva-Maria, additional, Staebler, Annette, additional, Hahn, Markus, additional, Brucker, Sara Yvonne, additional, and Hartkopf, Andreas Daniel, additional

Published
2024
Full Text
View/download PDF

80. CDK4/6 Inhibition – Therapy Sequences and the Quest to Find the Best Biomarkers – an Overview of Current Programs

Author

Schneeweiss, Andreas, additional, Brucker, Sara Y., additional, Huebner, Hanna, additional, Volmer, Lea L., additional, Hack, Carolin C., additional, Seitz, Katharina, additional, Ruebner, Matthias, additional, Heublein, Sabine, additional, Thewes, Verena, additional, Lüftner, Diana, additional, Lux, Michael P., additional, Jurhasz-Böss, Ingolf, additional, Taran, Florin-Andrei, additional, Wimberger, Pauline, additional, Anetsberger, Daniel, additional, Beierlein, Milena, additional, Schmidt, Marcus, additional, Radosa, Julia, additional, Müller, Volkmar, additional, Janni, Wolfgang, additional, Rack, Brigitte, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Ditsch, Nina, additional, Aktas, Bahriye, additional, Nel, Ivonne, additional, Kolberg, Hans-Christian, additional, Engerle, Tobias, additional, Tesch, Hans, additional, Roos, Christian, additional, Budden, Christina, additional, Neubauer, Hans, additional, Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, and Fasching, Peter A., additional

Published
2024
Full Text
View/download PDF

81. Attrition in the First Three Therapy Lines in Patients with Advanced Breast Cancer in the German Real-World PRAEGNANT Registry

Author

Hartkopf, Andreas D., primary, Walter, Christina B., primary, Kolberg, Hans-Christian, additional, Hadji, Peyman, additional, Tesch, Hans, additional, Fasching, Peter A., additional, Ettl, Johannes, additional, Lüftner, Diana, additional, Wallwiener, Markus, additional, Müller, Volkmar, additional, Beckmann, Matthias W., additional, Belleville, Erik, additional, Huebner, Hanna, additional, Uhrig, Sabrina, additional, Goossens, Chloë, additional, Link, Theresa, additional, Hielscher, Carsten, additional, Mundhenke, Christoph, additional, Kurbacher, Christian, additional, Wuerstlein, Rachel, additional, Untch, Michael, additional, Janni, Wolfgang, additional, Taran, Florin-Andrei, additional, Michel, Laura L., additional, Lux, Michael P., additional, Wallwiener, Diethelm, additional, Brucker, Sara Y., additional, Fehm, Tanja N., additional, Häberle, Lothar, additional, and Schneeweiss, Andreas, additional

Published
2024
Full Text
View/download PDF

82. Implementation and Evaluation of a Breast Cancer Disease Model Using Real-World Claims Data in Germany from 2010 to 2020

Author

Dannehl, Dominik, primary, von Au, Alexandra, additional, Engler, Tobias, additional, Volmer, Léa Louise, additional, Gutsfeld, Raphael, additional, Englisch, Johannes Felix, additional, Hahn, Markus, additional, Hawighorst-Knapstein, Sabine, additional, Chaudhuri, Ariane, additional, Bauer, Armin, additional, Wallwiener, Markus, additional, Taran, Florin-Andrei, additional, Wallwiener, Diethelm, additional, Brucker, Sara Yvonne, additional, Wallwiener, Stephanie, additional, Hartkopf, Andreas Daniel, additional, and Dijkstra, Tjeerd Maarten Hein, additional

Published
2024
Full Text
View/download PDF

83. AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2024

Author

Thill, Marc, primary, Janni, Wolfgang, additional, Albert, Ute-Susann, additional, Banys-Paluchowski, Maggie, additional, Bauerfeind, Ingo, additional, Blohmer, Jens, additional, Budach, Wilfried, additional, Dall, Peter, additional, Ditsch, Nina, additional, Fallenberg, Eva Maria, additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Friedrich, Michael, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Harbeck, Nadia, additional, Hartkopf, Andreas, additional, Heil, Jörg, additional, Huober, Jens, additional, Jackisch, Christian, additional, Kolberg-Liedtke, Cornelia, additional, Kreipe, Hans-Heinrich, additional, Krug, David, additional, Kühn, Thorsten, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Mundhenke, Christoph, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans-Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Würstlein, Rachel, additional, Müller, Volkmar, additional, and Park-Simon, Tjoung-Won, additional

Published
2024
Full Text
View/download PDF

85. Prognostic relevance of the HER2 status of circulating tumor cells in metastatic breast cancer patients screened for participation in the DETECT study program

Author

Müller, V., Banys-Paluchowski, M., Friedl, T.W.P., Fasching, P.A., Schneeweiss, A., Hartkopf, A., Wallwiener, D., Rack, B., Meier-Stiegen, F., Huober, J., Rübner, M., Hoffmann, O., Müller, L., Janni, W., Wimberger, P., Jäger, B., Pantel, K., Riethdorf, S., Harbeck, N., and Fehm, T.

Published
2021
Full Text
View/download PDF

87. Speckle interferometry at SOAR in 2015

Author

Tokovinin, Andrei, Mason, Brian D., Hartkopf, William I., Mendez, Rene A., and Horch, Elliott P.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The results of speckle interferometric observations at the SOAR telescope in 2015 are given, totalling 1303 measurements of 924 resolved binary and multiple stars and non-resolutions of 260 targets. The separations range from 12 mas to 3.37" (median 0.17"); the maximum measured magnitude difference is 6.7 mag. We resolved 27 pairs for the first time, including 10 as inner or outer subsystems in previously known binaries, e.g. the 50-mas pair in Epsilon Cha. Newly resolved pairs are commented upon. We discuss three apparently non-hierarchical systems discovered in this series, arguing that their unusual configuration results from projection. The resolved quadruple system HIP 71510 is studied as well., Comment: 10 pages, 8 figures. Accepted for publication in AJ. The online tables are not included, available from Tokovinin on request. arXiv admin note: text overlap with arXiv:1506.05718

Published
2016
Full Text
View/download PDF

88. Prognostic effect of low-level HER2 expression in patients with clinically negative HER2 status

Author

Hein, Alexander, Hartkopf, Andreas D., Emons, Julius, Lux, Michael P., Volz, Bernhard, Taran, Florin-Andrei, Overkamp, Friedrich, Hadji, Peyman, Tesch, Hans, Häberle, Lothar, Ettl, Johannes, Lüftner, Diana, Wurmthaler, Lena A., Wallwiener, Markus, Müller, Volkmar, Beckmann, Matthias W., Belleville, Erik, Wimberger, Pauline, Hielscher, Carsten, Kurbacher, Christian M., Wuerstlein, Rachel, Thomssen, Christoph, Untch, Michael, Fasching, Peter A., Janni, Wolfgang, Fehm, Tanja N., Wallwiener, Diethelm, Brucker, Sara Y., Schneeweiss, Andreas, and Kolberg, Hans-Christian

Published
2021
Full Text
View/download PDF

89. Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis

Author

Hartkopf, Andreas D., Brucker, Sara Y., Taran, Florin-Andrei, Harbeck, Nadia, von Au, Alexandra, Naume, Bjørn, Pierga, Jean-Yves, Hoffmann, Oliver, Beckmann, Matthias W., Rydén, Lisa, Fehm, Tanja, Aft, Rebecca, Solà, Montserrat, Walter, Vincent, Rack, Brigitte, Schuetz, Florian, Borgen, Elin, Ta, Minh-Hanh, Bittner, Ann-Kathrin, Fasching, Peter A., Fernö, Mårten, Krawczyk, Natalia, Weilbaecher, Katherine, Margelí, Mireia, Hahn, Markus, Jueckstock, Julia, Domschke, Christoph, Bidard, Francois-Clement, Kasimir-Bauer, Sabine, Schoenfisch, Birgitt, Kurt, Ayse G., Wallwiener, Markus, Gebauer, Gerhard, Klein, Christoph A., Wallwiener, Diethelm, Janni, Wolfgang, and Pantel, Klaus

Published
2021
Full Text
View/download PDF

91. Contribution to the Domestication and Conservation of the Genetic Diversity of Two Native Multipurpose Species in the Yabotí Biosphere Reserve, Misiones, Argentina

Author

Niella, Fernando, primary, Rocha, Patricia, additional, Tuzinkievicz, Ariel M., additional, Buchweis, Ricardo, additional, Bulman Hartkopf, Christian, additional, Thalmayr, Peggy, additional, González, José, additional, Montagnini, Florencia, additional, and Sharry, Sandra, additional

Published
2022
Full Text
View/download PDF

92. Acute relaxation during pregnancy leads to a reduction in maternal electrodermal activity and self-reported stress levels

Author

Ilena Bauer, Julia Hartkopf, Anna-Karin Wikström, Nora K. Schaal, Hubert Preissl, Birgit Derntl, and Franziska Schleger

Subjects
Pregnancy, Relaxation, Maternal stress, Heart rate, Electrodermal activity, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Prenatal maternal stress can have adverse effects on birth outcomes and fetal development. Relaxation techniques have been examined as potential countermeasures. This study investigates different relaxation techniques and their effect on self-reported stress levels and physiological stress levels in pregnant women. Methods In this cross-sectional study, 38 pregnant women in their 30th to 40th gestational week were assigned to one of three, 20-min lasting relaxation groups: listening to music (N = 12), following a guided imagery (N = 12) or resting (N = 12). The intervention, i.e., acute relaxation (music, guided imagery or resting) took place once for each study participant. Study inclusion criteria were age over 18 years, German speaking, singleton and uncomplicated pregnancy during the 30th and 40th week of gestation. The stress levels were determined during the study. Current stress level during the study was assessed by a visual analogue scale. Chronic stress levels were assessed by the Trier Inventory of Chronic Stress and the Pregnancy Distress questionnaire. Multivariate analyses of covariance were performed and dependent measures included stress levels as well as physiological measures, i.e., cardiovascular activity (electrocardiogram) and skin conductance levels. Results All three forms of relaxation led to reduced maternal stress which manifested itself in significantly decreased skin conductance, F(3,94) = 18.011, p = .001, ηp 2 = .365, and subjective stress levels after the interventions with no significant group difference. Post-intervention stress ratings were further affected by gestational age, with less subjective relaxation in women later in gestation, F (1, 34)=4.971, p = .032, ηp 2 = .128. Conclusion Independent of relaxation technique, single, 20-min relaxation intervention (music, guided imagery or resting) can significantly reduce maternal stress. Notably, women at an earlier stage in their pregnancy reported higher relaxation after the intervention than women later in gestation. Hence, gestational age may influence perceived stress levels and should be considered when evaluating relaxation or stress management interventions during pregnancy. Trial registration Not applicable.

Published
2021
Full Text
View/download PDF

93. A global metagenomic map of urban microbiomes and antimicrobial resistance

Author

Abdullah, Natasha, Abraao, Marcos, Adel, Ait-hamlat, Afaq, Muhammad, Al-Quaddoomi, Faisal S., Alam, Ireen, Albuquerque, Gabriela E., Alexiev, Alex, Ali, Kalyn, Alvarado-Arnez, Lucia E., Aly, Sarh, Amachee, Jennifer, Amorim, Maria G., Ampadu, Majelia, Amran, Muhammad Al-Fath, An, Nala, Andrew, Watson, Andrianjakarivony, Harilanto, Angelov, Michael, Antelo, Verónica, Aquino, Catharine, Aranguren, Álvaro, Araujo, Luiza F., Vasquez Arevalo, Hitler Francois, Arevalo, Jenny, Arnan, Carme, Alvarado Arnez, Lucia Elena, Arredondo, Fernanda, Arthur, Matthew, Asenjo, Freddy, Aung, Thomas Saw, Auvinet, Juliette, Aventin, Nuria, Ayaz, Sadaf, Baburyan, Silva, Bakere, Abd-Manaaf, Bakhl, Katrin, Bartelli, Thais F., Batdelger, Erdenetsetseg, Baudon, François, Becher, Kevin, Bello, Carla, Benchouaia, Médine, Benisty, Hannah, Benoiston, Anne-Sophie, Benson, Joseph, Benítez, Diego, Bernardes, Juliana, Bertrand, Denis, Beurmann, Silvia, Bitard-Feildel, Tristan, Bittner, Lucie, Black, Christina, Blanc, Guillaume, Blyther, Brittany, Bode, Toni, Boeri, Julia, Boldgiv, Bazartseren, Bolzli, Kevin, Bordigoni, Alexia, Borrelli, Ciro, Bouchard, Sonia, Bouly, Jean-Pierre, Boyd, Alicia, Branco, Gabriela P., Breschi, Alessandra, Brindefalk, Björn, Brion, Christian, Briones, Alan, Buczansla, Paulina, Burke, Catherine M., Burrell, Aszia, Butova, Alina, Buttar, Irvind, Bynoe, Jalia, Bönigk, Sven, Bøifot, Kari O., Caballero, Hiram, Cai, Xiao Wen, Calderon, Dayana, Cantillo, Angela, Carbajo, Miguel, Carbone, Alessandra, Cardenas, Anais, Carrillo, Katerine, Casalot, Laurie, Castro, Sofia, Castro, Ana V., Castro, Astred, Castro, Ana Valeria B., Cawthorne, Simone, Cedillo, Jonathan, Chaker, Salama, Chalangal, Jasna, Chan, Allison, Chasapi, Anastasia I., Chatziefthimiou, Starr, Chaudhuri, Sreya Ray, Chavan, Akash Keluth, Chavez, Francisco, Chem, Gregory, Chen, Xiaoqing, Chen, Michelle, Chen, Jenn-Wei, Chernomoretz, Ariel, Chettouh, Allaeddine, Cheung, Daisy, Chicas, Diana, Chiu, Shirley, Choudhry, Hira, Chrispin, Carl, Ciaramella, Kianna, Cifuentes, Erika, Cohen, Jake, Coil, David A., Collin, Sylvie, Conger, Colleen, Conte, Romain, Corsi, Flavia, Cossio, Cecilia N., Costa, Ana F., Cuebas, Delisia, D’Alessandro, Bruno, Dahlhausen, Katherine E., Darling, Aaron E., Das, Pujita, Davenport, Lucinda B., David, Laurent, Davidson, Natalie R., Dayama, Gargi, Delmas, Stéphane, Deng, Chris K., Dequeker, Chloé, Desert, Alexandre, Devi, Monika, Dezem, Felipe S., Dias, Clara N., Donahoe, Timothy Ryan, Dorado, Sonia, Dorsey, LaShonda, Dotsenko, Valeriia, Du, Steven, Dutan, Alexandra, Eady, Naya, Eisen, Jonathan A., Elaskandrany, Miar, Epping, Lennard, Escalera-Antezana, Juan P., Ettinger, Cassie L., Faiz, Iqra, Fan, Luice, Farhat, Nadine, Faure, Emile, Fauzi, Fazlina, Feigin, Charlie, Felice, Skye, Ferreira, Laís Pereira, Figueroa, Gabriel, Fleiss, Aubin, Flores, Denisse, Velasco Flores, Jhovana L., Fonseca, Marcos A.S., Foox, Jonathan, Forero, Juan Carlos, Francis, Aaishah, French, Kelly, Fresia, Pablo, Friedman, Jacob, Fuentes, Jaime J., Galipon, Josephine, Garcia, Mathilde, Garcia, Laura, García, Catalina, Geiger, Annie, Gerner, Samuel M., Ghose, Sonia L., Giang, Dao Phuong, Giménez, Matías, Giovannelli, Donato, Githae, Dedan, Gkotzis, Spyridon, Godoy, Liliana, Goldman, Samantha, Gonnet, Gaston H., Gonzalez, Juana, Gonzalez, Andrea, Gonzalez-Poblete, Camila, Gray, Andrew, Gregory, Tranette, Greselle, Charlotte, Guasco, Sophie, Guerra, Juan, Gurianova, Nika, Haehr, Wolfgang, Halary, Sebastien, Hartkopf, Felix, Hastings, Jaden J.A., Hawkins-Zafarnia, Arya, Hazrin-Chong, Nur Hazlin, Helfrich, Eric, Hell, Eva, Henry, Tamera, Hernandez, Samuel, Hernandez, Pilar Lopez, Hess-Homeier, David, Hittle, Lauren E., Hoan, Nghiem Xuan, Holik, Aliaksei, Homma, Chiaki, Hoxie, Irene, Huber, Michael, Humphries, Elizabeth, Hyland, Stephanie, Hässig, Andrea, Häusler, Roland, Hüsser, Nathalie, Petit, Robert A., III, Iderzorig, Badamnyambuu, Igarashi, Mizuki, Iqbal, Shaikh B., Ishikawa, Shino, Ishizuka, Sakura, Islam, Sharah, Islam, Riham, Ito, Kohei, Ito, Sota, Ito, Takayuki, Ivankovic, Tomislav, Iwashiro, Tomoki, Jackson, Sarah, Jacobs, JoAnn, James, Marisano, Jaubert, Marianne, Jerier, Marie-Laure, Jiminez, Esmeralda, Jinfessa, Ayantu, De Jong, Ymke, Joo, Hyun Woo, Jospin, Guilllaume, Kajita, Takema, Ahmad Kassim, Affifah Saadah, Kato, Nao, Kaur, Amrit, Kaur, Inderjit, de Souza Gomes Kehdy, Fernanda, Khadka, Vedbar S., Khan, Shaira, Khavari, Mahshid, Ki, Michelle, Kim, Gina, Kim, Hyung Jun, Kim, Sangwan, King, Ryan J., Knights, Kaymisha, KoLoMonaco, Giuseppe, Koag, Ellen, Kobko-Litskevitch, Nadezhda, Korshevniuk, Maryna, Kozhar, Michael, Krebs, Jonas, Kubota, Nanami, Kuklin, Andrii, Kumar, Sheelta S., Kwong, Rachel, Kwong, Lawrence, Lafontaine, Ingrid, Lago, Juliana, Lai, Tsoi Ying, Laine, Elodie, Laiola, Manolo, Lakhneko, Olha, Lamba, Isha, de Lamotte, Gerardo, Lannes, Romain, De Lazzari, Eleonora, Leahy, Madeline, Lee, Hyunjung, Lee, Yunmi, Lee, Lucy, Lemaire, Vincent, Leong, Emily, Leung, Marcus H.Y., Lewandowska, Dagmara, Li, Chenhao, Liang, Weijun, Lin, Moses, Lisboa, Priscilla, Litskevitch, Anna, Liu, Eric Minwei, Liu, Tracy, Livia, Mayra Arauco, Lo, Yui Him, Losim, Sonia, Loubens, Manon, Lu, Jennifer, Lykhenko, Olexandr, Lysakova, Simona, Mahmoud, Salah, Majid, Sara Abdul, Makogon, Natalka, Maldonado, Denisse, Mallari, Krizzy, Malta, Tathiane M., Mamun, Maliha, Manoir, Dimitri, Marchandon, German, Marciniak, Natalia, Marinovic, Sonia, Marques, Brunna, Mathews, Nicole, Matsuzaki, Yuri, Matthys, Vincent, May, Madelyn, McComb, Elias, Meagher, Annabelle, Melamed, Adiell, Menary, Wayne, Mendez, Katterinne N., Mendez, Ambar, Mendy, Irène Mauricette, Meng, Irene, Menon, Ajay, Menor, Mark, Meoded, Roy, Merino, Nancy, Meydan, Cem, Miah, Karishma, Mignotte, Mathilde, Miketic, Tanja, Miranda, Wilson, Mitsios, Athena, Miura, Ryusei, Miyake, Kunihiko, Moccia, Maria D., Mohan, Natasha, Mohsin, Mohammed, Moitra, Karobi, Moldes, Mauricio, Molina, Laura, Molinet, Jennifer, Molomjamts, Orgil-Erdene, Moniruzzaman, Eftar, Moon, Sookwon, de Oliveira Moraes, Isabelle, Moreno, Mario, Mosella, Maritza S., Moser, Josef W., Mozsary, Christopher, Muehlbauer, Amanda L., Muner, Oasima, Munia, Muntaha, Munim, Naimah, Muscat, Maureen, Mustac, Tatjana, Muñoz, Cristina, Nadalin, Francesca, Naeem, Areeg, Nagy-Szakal, Dorottya, Nakagawa, Mayuko, Narce, Ashanti, Nasu, Masaki, Navarrete, Irene González, Naveed, Hiba, Nazario, Bryan, Nedunuri, Narasimha Rao, Neff, Thomas, Nesimi, Aida, Ng, Wan Chiew, Ng, Synti, Nguyen, Gloria, Ngwa, Elsy, Nicolas, Agier, Nicolas, Pierre, Nika, Abdollahi, Noorzi, Hosna, Nosrati, Avigdor, Noushmehr, Houtan, Nunes, Diana N., O’Brien, Kathryn, O’Hara, Niamh B., Oken, Gabriella, Olawoyin, Rantimi A., Oliete, Javier Quilez, Olmeda, Kiara, Oluwadare, Tolulope, Oluwadare, Itunu A., Ordioni, Nils, Orpilla, Jenessa, Orrego, Jacqueline, Ortega, Melissa, Osma, Princess, Osuolale, Israel O., Osuolale, Oluwatosin M., Ota, Mitsuki, Oteri, Francesco, Oto, Yuya, Ounit, Rachid, Ouzounis, Christos A., Pakrashi, Subhamitra, Paras, Rachel, Pardo-Este, Coral, Park, Young-Ja, Pastuszek, Paulina, Patel, Suraj, Pathmanathan, Jananan, Patrignani, Andrea, Perez, Manuel, Peros, Ante, Persaud, Sabrina, Peters, Anisia, Phillips, Adam, Pineda, Lisbeth, Pizzi, Melissa P., Plaku, Alma, Plaku, Alketa, Pompa-Hogan, Brianna, Portilla, María Gabriela, Posada, Leonardo, Priestman, Max, Prithiviraj, Bharath, Priya, Sambhawa, Pugdeethosal, Phanthira, Pugh, Catherine E., Pulatov, Benjamin, Pupiec, Angelika, Pyrshev, Kyrylo, Qing, Tao, Rahiel, Saher, Rahmatulloev, Savlatjon, Rajendran, Kannan, Ramcharan, Aneisa, Ramirez-Rojas, Adan, Rana, Shahryar, Ratnanandan, Prashanthi, Read, Timothy D., Rehrauer, Hubert, Richer, Renee, Rivera, Alexis, Rivera, Michelle, Robertiello, Alessandro, Robinson, Courtney, Rodríguez, Paula, Rojas, Nayra Aguilar, Roldán, Paul, Rosario, Anyelic, Roth, Sandra, Ruiz, Maria, Boja Ruiz, Stephen Eduard, Russell, Kaitlan, Rybak, Mariia, Sabedot, Thais S., Sabina, Mahfuza, Saito, Ikuto, Saito, Yoshitaka, Malca Salas, Gustavo Adolfo, Salazar, Cecilia, San, Kaung Myat, Sanchez, Jorge, Sanchir, Khaliun, Sankar, Ryan, de Souza Santos, Paulo Thiago, Saravi, Zulena, Sasaki, Kai, Sato, Yuma, Sato, Masaki, Sato, Seisuke, Sato, Ryo, Sato, Kaisei, Sayara, Nowshin, Schaaf, Steffen, Schacher, Oli, Schinke, Anna-Lena M., Schlapbach, Ralph, Schori, Christian, Schriml, Jason R., Segato, Felipe, Sepulveda, Felipe, Serpa, Marianna S., De Sessions, Paola F., Severyn, Juan C., Shaaban, Heba, Shakil, Maheen, Shalaby, Sarah, Shari, Aliyah, Shim, Hyenah, Shirahata, Hikaru, Shiwa, Yuh, Siam, Rania, Da Silva, Ophélie, Silva, Jordana M., Simon, Gwenola, Singh, Shaleni K., Sluzek, Kasia, Smith, Rebecca, So, Eunice, Andreu Somavilla, Núria, Sonohara, Yuya, Rufino de Sousa, Nuno, Souza, Camila, Sperry, Jason, Sprinsky, Nicolas, Stark, Stefan G., La Storia, Antonietta, Suganuma, Kiyoshi, Suliman, Hamood, Sullivan, Jill, Supie, Arif Asyraf Md, Suzuki, Chisato, Takagi, Sora, Takahara, Fumie, Takahashi, Naoya, Takahashi, Kou, Takeda, Tomoki, Takenaka, Isabella K., Tanaka, Soma, Tang, Anyi, Man Tang, Yuk, Tarcitano, Emilio, Tassinari, Andrea, Taye, Mahdi, Terrero, Alexis, Thambiraja, Eunice, Thiébaut, Antonin, Thomas, Sade, Thomas, Andrew M., Togashi, Yuto, Togashi, Takumi, Tomaselli, Anna, Tomita, Masaru, Tomita, Itsuki, Tong, Xinzhao, Toth, Oliver, Toussaint, Nora C., Tran, Jennifer M., Truong, Catalina, Tsonev, Stefan I., Tsuda, Kazutoshi, Tsurumaki, Takafumi, Tuz, Michelle, Tymoshenko, Yelyzaveta, Urgiles, Carmen, Usui, Mariko, Vacant, Sophie, Valentine, Brandon, Vann, Laura E., Velter, Fabienne, Ventorino, Valeria, Vera-Wolf, Patricia, Vicedomini, Riccardo, Suarez-Villamil, Michael A., Vincent, Sierra, Vivancos-Koopman, Renee, Wan, Andrew, Wang, Cindy, Warashina, Tomoro, Watanabe, Ayuki, Weekes, Samuel, Werner, Johannes, Westfall, David, Wieler, Lothar H., Williams, Michelle, Wolf, Silver A., Wong, Brian, Wong, Yan Ling, Wong, Tyler, Wright, Rasheena, Wunderlin, Tina, Yamanaka, Ryota, Yang, Jingcheng, Yano, Hirokazu, Yeh, George C., Yemets, Olena, Yeskova, Tetiana, Yoshikawa, Shusei, Zafar, Laraib, Zhang, Yang, Zhang, Shu, Zhang, Amy, Zheng, Yuanting, Zubenko, Stas, Danko, David, Bezdan, Daniela, Afshin, Evan E., Ahsanuddin, Sofia, Bhattacharya, Chandrima, Butler, Daniel J., Chng, Kern Rei, Donnellan, Daisy, Hecht, Jochen, Jackson, Katelyn, Kuchin, Katerina, Karasikov, Mikhail, Lyons, Abigail, Mak, Lauren, Meleshko, Dmitry, Mustafa, Harun, Mutai, Beth, Neches, Russell Y., Ng, Amanda, Nikolayeva, Olga, Nikolayeva, Tatyana, Png, Eileen, Ryon, Krista A., Sanchez, Jorge L., Sierra, Maria A., Thomas, Dominique, Young, Ben, Abudayyeh, Omar O., Alicea, Josue, Bhattacharyya, Malay, Blekhman, Ran, Castro-Nallar, Eduardo, Cañas, Ana M., Chatziefthimiou, Aspassia D., Crawford, Robert W., De Filippis, Francesca, Deng, Youping, Desnues, Christelle, Dias-Neto, Emmanuel, Dybwad, Marius, Elhaik, Eran, Ercolini, Danilo, Frolova, Alina, Gankin, Dennis, Gootenberg, Jonathan S., Graf, Alexandra B., Green, David C., Hajirasouliha, Iman, Hernandez, Mark, Iraola, Gregorio, Jang, Soojin, Kahles, Andre, Kelly, Frank J., Kyrpides, Nikos C., Łabaj, Paweł P., Lee, Patrick K.H., Ljungdahl, Per O., Mason-Buck, Gabriella, McGrath, Ken, Mongodin, Emmanuel F., Moraes, Milton Ozorio, Nagarajan, Niranjan, Nieto-Caballero, Marina, Oliveira, Manuela, Ossowski, Stephan, Osuolale, Olayinka O., Özcan, Orhan, Paez-Espino, David, Rascovan, Nicolás, Richard, Hugues, Rätsch, Gunnar, Schriml, Lynn M., Semmler, Torsten, Sezerman, Osman U., Shi, Leming, Shi, Tieliu, Song, Le Huu, Suzuki, Haruo, Court, Denise Syndercombe, Tighe, Scott W., Udekwu, Klas I., Ugalde, Juan A., Vassilev, Dimitar I., Vayndorf, Elena M., Velavan, Thirumalaisamy P., Wu, Jun, Zambrano, María M., Zhu, Jifeng, Zhu, Sibo, and Mason, Christopher E.

Published
2021
Full Text
View/download PDF

95. Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Author

Goode, Ellen L, Block, Matthew S, Kalli, Kimberly R, Vierkant, Robert A, Chen, Wenqian, Fogarty, Zachary C, Gentry-Maharaj, Aleksandra, Tołoczko, Aleksandra, Hein, Alexander, Bouligny, Aliecia L, Jensen, Allan, Osorio, Ana, Hartkopf, Andreas D, Ryan, Andy, Chudecka-Głaz, Anita, Magliocco, Anthony M, Hartmann, Arndt, Jung, Audrey Y, Gao, Bo, Hernandez, Brenda Y, Fridley, Brooke L, McCauley, Bryan M, Kennedy, Catherine J, Wang, Chen, Karpinskyj, Chloe, de Sousa, Christiani B, Tiezzi, Daniel G, Wachter, David L, Herpel, Esther, Taran, Florin Andrei, Modugno, Francesmary, Nelson, Gregg, Lubiński, Jan, Menkiszak, Janusz, Alsop, Jennifer, Lester, Jenny, García-Donas, Jesús, Nation, Jill, Hung, Jillian, Palacios, José, Rothstein, Joseph H, Kelley, Joseph L, de Andrade, Jurandyr M, Robles-Díaz, Luis, Intermaggio, Maria P, Widschwendter, Martin, Beckmann, Matthias W, Ruebner, Matthias, Jimenez-Linan, Mercedes, Singh, Naveena, Oszurek, Oleg, Harnett, Paul R, Rambau, Peter F, Sinn, Peter, Wagner, Philipp, Ghatage, Prafull, Sharma, Raghwa, Edwards, Robert P, Ness, Roberta B, Orsulic, Sandra, Brucker, Sara Y, Johnatty, Sharon E, Longacre, Teri A, Eilber, Ursula, McGuire, Valerie, Sieh, Weiva, Natanzon, Yanina, Li, Zheng, Whittemore, Alice S, deFazio, Anna, Staebler, Annette, Karlan, Beth Y, Gilks, Blake, Bowtell, David D, Høgdall, Estrid, dos Reis, Francisco J Candido, Steed, Helen, Campbell, Ian G, Gronwald, Jacek, Benítez, Javier, Koziak, Jennifer M, Chang-Claude, Jenny, Moysich, Kirsten B, Kelemen, Linda E, Cook, Linda S, Goodman, Marc T, García, María José, Fasching, Peter A, Kommoss, Stefan, Deen, Suha, Kjaer, Susanne K, Menon, Usha, Brenton, James D, Pharoah, Paul DP, Chenevix-Trench, Georgia, Huntsman, David G, Winham, Stacey J, Köbel, Martin, and Ramus, Susan J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Prevention, Vaccine Related, Rare Diseases, Clinical Research, Ovarian Cancer, BRCA2 Protein, CD8 Antigens, Carcinoma, Ovarian Epithelial, Cohort Studies, Cystadenocarcinoma, Serous, Female, Humans, Lymphocytes, Tumor-Infiltrating, Middle Aged, Mutation, Neoplasm Grading, Ovarian Neoplasms, Prospective Studies, Survival Analysis, Treatment Outcome, Ovarian Tumor Tissue Analysis (OTTA) Consortium, Public Health and Health Services, Oncology and carcinogenesis
Abstract

ImportanceCytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to other clinical factors.ObjectiveTo define the prognostic role of CD8+ TILs in epithelial ovarian cancer.Design, setting, and participantsThis was a multicenter observational, prospective survival cohort study of the Ovarian Tumor Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade serous ovarian carcinomas (HGSOCs), were followed prospectively for over 24 650 person-years.ExposuresFollowing immunohistochemical analysis, CD8+ TILs were identified within the epithelial components of tumor islets. Patients were grouped based on the estimated number of CD8+ TILs per high-powered field: negative (none), low (1-2), moderate (3-19), and high (≥20). CD8+ TILs in a subset of patients were also assessed in a quantitative, uncategorized manner, and the functional form of associations with survival was assessed using penalized B-splines.Main outcomes and measuresOverall survival time.ResultsThe final sample included 5577 women; mean age at diagnosis was 58.4 years (median, 58.2 years). Among the 5 major invasive histotypes, HGSOCs showed the most infiltration. CD8+ TILs in HGSOCs were significantly associated with longer overall survival; median survival was 2.8 years for patients with no CD8+ TILs and 3.0 years, 3.8 years, and 5.1 years for patients with low, moderate, or high levels of CD8+ TILs, respectively (P value for trend = 4.2 × 10−16). A survival benefit was also observed among women with endometrioid and mucinous carcinomas, but not for those with the other histotypes. Among HGSOCs, CD8+ TILs were favorable regardless of extent of residual disease following cytoreduction, known standard treatment, and germline BRCA1 pathogenic mutation, but were not prognostic for BRCA2 mutation carriers. Evaluation of uncategorized CD8+ TIL counts showed a near-log-linear functional form.Conclusions and relevanceThis study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival. That the extent of infiltration is prognostic, not merely its presence or absence, suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.

Published
2017

96. Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

Author

Ovarian Tumor Tissue Analysis (OTTA) Consortium, Goode, Ellen L, Block, Matthew S, Kalli, Kimberly R, Vierkant, Robert A, Chen, Wenqian, Fogarty, Zachary C, Gentry-Maharaj, Aleksandra, Tołoczko, Aleksandra, Hein, Alexander, Bouligny, Aliecia L, Jensen, Allan, Osorio, Ana, Hartkopf, Andreas, Ryan, Andy, Chudecka-Głaz, Anita, Magliocco, Anthony M, Hartmann, Arndt, Jung, Audrey Y, Gao, Bo, Hernandez, Brenda Y, Fridley, Brooke L, McCauley, Bryan M, Kennedy, Catherine J, Wang, Chen, Karpinskyj, Chloe, de Sousa, Christiani B, Tiezzi, Daniel G, Wachter, David L, Herpel, Esther, Taran, Florin Andrei, Modugno, Francesmary, Nelson, Gregg, Lubiński, Jan, Menkiszak, Janusz, Alsop, Jennifer, Lester, Jenny, García-Donas, Jesús, Nation, Jill, Hung, Jillian, Palacios, José, Rothstein, Joseph H, Kelley, Joseph L, de Andrade, Jurandyr M, Robles-Díaz, Luis, Intermaggio, Maria P, Widschwendter, Martin, Beckmann, Matthias W, Ruebner, Matthias, Jimenez-Linan, Mercedes, Singh, Naveena, Oszurek, Oleg, Harnett, Paul R, Rambau, Peter F, Sinn, Peter, Wagner, Philipp, Ghatage, Prafull, Sharma, Raghwa, Edwards, Robert P, Ness, Roberta B, Orsulic, Sandra, Brucker, Sara Y, Johnatty, Sharon E, Longacre, Teri A, Ursula, Eilber, McGuire, Valerie, Sieh, Weiva, Natanzon, Yanina, Li, Zheng, Whittemore, Alice S, Anna, deFazio, Staebler, Annette, Karlan, Beth Y, Gilks, Blake, Bowtell, David D, Høgdall, Estrid, Candido dos Reis, Francisco J, Steed, Helen, Campbell, Ian G, Gronwald, Jacek, Benítez, Javier, Koziak, Jennifer M, Chang-Claude, Jenny, Moysich, Kirsten B, Kelemen, Linda E, Cook, Linda S, Goodman, Marc T, García, María José, Fasching, Peter A, Kommoss, Stefan, Deen, Suha, Kjaer, Susanne K, Menon, Usha, Brenton, James D, Pharoah, Paul DP, Chenevix-Trench, Georgia, Huntsman, David G, Winham, Stacey J, Köbel, Martin, and Ramus, Susan J

Subjects
Ovarian Tumor Tissue Analysis (OTTA) Consortium, Lymphocytes, Tumor-Infiltrating, Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, BRCA2 Protein, Treatment Outcome, Survival Analysis, Cohort Studies, Prospective Studies, Mutation, Middle Aged, Female, Neoplasm Grading, CD8 Antigens, Carcinoma, Ovarian Epithelial, Lymphocytes, Tumor-Infiltrating, Cystadenocarcinoma, Serous, Carcinoma, Ovarian Epithelial, Cancer, Prevention, Ovarian Cancer, Rare Diseases, Vaccine Related, Clinical Research, Oncology and Carcinogenesis, Public Health and Health Services
Abstract

ImportanceCytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to other clinical factors.ObjectiveTo define the prognostic role of CD8+ TILs in epithelial ovarian cancer.Design, setting, and participantsThis was a multicenter observational, prospective survival cohort study of the Ovarian Tumor Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade serous ovarian carcinomas (HGSOCs), were followed prospectively for over 24 650 person-years.ExposuresFollowing immunohistochemical analysis, CD8+ TILs were identified within the epithelial components of tumor islets. Patients were grouped based on the estimated number of CD8+ TILs per high-powered field: negative (none), low (1-2), moderate (3-19), and high (≥20). CD8+ TILs in a subset of patients were also assessed in a quantitative, uncategorized manner, and the functional form of associations with survival was assessed using penalized B-splines.Main outcomes and measuresOverall survival time.ResultsThe final sample included 5577 women; mean age at diagnosis was 58.4 years (median, 58.2 years). Among the 5 major invasive histotypes, HGSOCs showed the most infiltration. CD8+ TILs in HGSOCs were significantly associated with longer overall survival; median survival was 2.8 years for patients with no CD8+ TILs and 3.0 years, 3.8 years, and 5.1 years for patients with low, moderate, or high levels of CD8+ TILs, respectively (P value for trend = 4.2 × 10−16). A survival benefit was also observed among women with endometrioid and mucinous carcinomas, but not for those with the other histotypes. Among HGSOCs, CD8+ TILs were favorable regardless of extent of residual disease following cytoreduction, known standard treatment, and germline BRCA1 pathogenic mutation, but were not prognostic for BRCA2 mutation carriers. Evaluation of uncategorized CD8+ TIL counts showed a near-log-linear functional form.Conclusions and relevanceThis study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival. That the extent of infiltration is prognostic, not merely its presence or absence, suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.

Published
2017

100. Densidad y proporción de albura y duramen en nuevos clones de Eucalyptus spp

Author

Bulman Hartkopf, Christian, Winck, Rosa Angela, Aquino, Diego Rolando, Fassola, Hugo Enrique, Stefani, Pablo M., Bulman Hartkopf, Christian, Winck, Rosa Angela, Aquino, Diego Rolando, Fassola, Hugo Enrique, and Stefani, Pablo M.

Abstract

La generación de nuevos materiales genéticos para atender las diversas demandas del mercado de la madera requiere una constante evaluación de sus propiedades tecnológicas. En el presente estudio, se evaluó el contenido relativo de duramen y albura a tres alturas de fuste (0,10 m, 2,80 m y 5,50 m) así como la variación de densidad en dirección axial y radial de clones puros Eucalyptus grandis (rose gum) e híbridos (Eucalyptus grandis (rose gum) x Eucalyptus camaldulensis (red gum) y Eucalyptus grandis (rose gum) x Eucalyptus tereticornis (red irongum)) de 11 años de edad. Los clones puros mostraron un 10 % más de duramen que los híbridos. El material híbrido alcanzó el mayor valor medio de densidades, siendo más homogéneo en el perfil radial y axial. En general, la densidad presentó un patrón creciente en la dirección radial. No se encontraron diferencias significativas en la densidad para las alturas estudiadas en los clones híbridos, mientras que los clones puros presentaron valores de densidad significativamente mayores a 0,10 m. La densidad de la albura fue mayor que la del duramen para las tres alturas de fuste en todos los materiales genéticos. El análisis de los resultados indica que los clones híbridos podrían ser aptos para la producción de pulpa de celulosa debido a la menor proporción de duramen, lo cual facilita el proceso de blanqueo, así como para su uso como madera aserrada o contrachapado estructural por su mayor densidad y homogeneidad en altura, La generación de nuevos materiales genéticos para atender las diversas demandas del mercado de la madera requiere una constante evaluación de sus propiedades tecnológicas. En el presente estudio, se evaluó el contenido relativo de duramen y albura a tres alturas de fuste (0,10 m, 2,80 m y 5,50 m) así como la variación de densidad en dirección axial y radial de clones puros Eucalyptus grandis (rose gum) e híbridos (Eucalyptus grandis (rose gum) x Eucalyptus camaldulensis (red gum) y Eucalyptus grandis (rose gum) x Eucalyptus tereticornis (red irongum)) de 11 años de edad. Los clones puros mostraron un 10 % más de duramen que los híbridos. El material híbrido alcanzó el mayor valor medio de densidades, siendo más homogéneo en el perfil radial y axial. En general, la densidad presentó un patrón creciente en la dirección radial. No se encontraron diferencias significativas en la densidad para las alturas estudiadas en los clones híbridos, mientras que los clones puros presentaron valores de densidad significativamente mayores a 0,10 m. La densidad de la albura fue mayor que la del duramen para las tres alturas de fuste en todos los materiales genéticos. El análisis de los resultados indica que los clones híbridos podrían ser aptos para la producción de pulpa de celulosa debido a la menor proporción de duramen, lo cual facilita el proceso de blanqueo, así como para su uso como madera aserrada o contrachapado estructural por su mayor densidad y homogeneidad en altura.

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results