OBJECTIVE: To systematically review the efficacy and safety of conventional treatment combined with Suhuang Zhike capsule for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS: Retrieved from PubMed, the Cochrane Library, Embase, Web of Science, CNKI, CBM, Wanfang Data, VIP database, etc., randomized controlled trials about conventional treatment combined with Suhuang Zhike capsule for AECOPD were collected, and the references of included literature were manually searched for supplementary retrieval from the inception to Jun. 2021. After literature screening, quality evaluation and data extraction of included studies, Meta-analysis was carried out by using RevMan 5. 3 software, and Stata 15. 1 software was used to evaluate publication bias. RESULTS: A total of 1 680 patients with AECOPD were enrolled in 17 studies. Meta-analysis results showed that conventional treatment combined with Suhuang Zhike capsule was better than conventional treatment in improving total response rate (RR = 1. 17,95%CI = 1. 12-1. 22,P<0. 000 01), forced expiratory volume at 1 second (FEV1) (MD =0. 38,95%CI =0. 26-0. 49,P<0. 000 01), the percentage of forced expiratory volume at 1 second in forced vital capacity (FEV1 / FVC) (MD = 11. 44,95%CI = 7. 67-15. 22,P <0. 000 01), and C-reactive protein (CRP) level (SMD =-0. 97,95%CI =-1. 36--0. 59,P<0. 000 01),with statistically significant difference; there was no statistical significance in the incidence of adverse drug reaction between two groups (RR =1. 33,95%CI =0. 85-2. 08,P =0. 21). Results of publication bias test and non-parametric trim and fill method showed bias in the outcome indexes of total effective rate, but the possible publication bias did not affect the results. CONCLUSIONS: Based on the existing evidence, Suhuang Zhike capsule has positive efficacy in the adjuvant treatment of AECOPD, can improve the levels of lung function indicators (FEV1, FEV1 / FVC) and reduce the level of inflammation index (CRP), and shows good safety, but the above results still need to be reviewed with caution. [ABSTRACT FROM AUTHOR]