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Objective: To investigate the levels of uric acid and nucleotide-binding oligomerization domain-leucine-rich repeats containing pyrin domain 3(NLRP3) inflammasome expression in pregnant women with hypertensive disorder complicating pregnancy(HDCP) and their correlation with HDCP. Methods: 200 pregnant women who received routine antenatal examination and were diagnosed with HDCP in the department of obstetrics from March 2016 to March 2019 were selected as research group. According to the grading standard referring to the Guidelines for the Diagnosis and Treatment of Hypertensive Disorder Complicating Pregnancy(2015),200 pregnant women in research group were divided into the gestational hypertension group(86 cases), mild pre-eclampsia group(57 cases), and severe pre-eclampsia group(57 cases). 200 healthy pregnant women who received routine antenatal examination were selected as control group. The serum uric acid, NLRP3 inflammasome m RNA, NLRP3 protein expression were compared among the four groups. The correlation between the indicators and the disease was examined by bivariate Spearman correlation analysis. Results: There was no statistical difference in the maternal age, gestational weeks, gravidity, parity among the four groups(P>0.05); Among four groups,the serum uric acid level, NLRP3 mRNA expression, NLRP3 protein expression in severe pre-eclampsia group were the highest, followed by mild pre-eclampsia group, gestational hypertension group and control group, and the difference was statistically significant(P<0.05);Bivariate Spearman correlation analysis confirmed that the serum uric acid, NLRP3 mRNA expression, NLRP3 protein expression had positive correlation with the occurrence and development of HDCP(r=0.709, 0.833, 0.693, P<0.001). Conclusion: The levels of uric acid and NLRP3 inflammasome in pregnant women with HDCP increase. With the aggravation of maternal conditions, uric acid and NLRP3 inflammasome can be used as serological indicators for early diagnosis and prognostic evaluation of HDCP. [ABSTRACT FROM AUTHOR]

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