Search

目的 总结伴有先天性巨结肠的 Rubinstein-Taybi综合征 (Rubinstein-Taybi syndrome, RSTS) 的有效诊断 方法. 方法 对1例伴有先天性巨结肠的 RSTS 患儿的诊断过程作回顾性分析. 结果 患儿, 男, 主要临床表现为 先天性巨结肠, 颅面畸形, 漏斗胸, 双侧拇指及踇趾宽大, 伴有生长迟滞, 智力及运动发育迟缓. 患儿行全结肠切除 术, 术中行腹直肌肌肉组织活检可见单个和成簇萎缩肌纤维, 部分肌纤维肌膜下或胞质存在单个或多个大小不等空 泡, 术后病理组织检查可见全结肠肠壁充血, 水肿, 黏膜下及肌间见神经节细胞, 发育不良, 并见较多粗大神经纤维, 部分肠壁纤维增生. 术后考虑患儿存在肌源性损伤. 为明确病因, 对患儿腹直肌肌肉组织进行全外显子 (含线粒 体) 组基因测序, 结果显示患儿 16号染色体 CREBBP 基因外显子 c. 2911A>G (p. R971G) 杂合突变. 结合患儿临床 表现, 明确诊断为RSTS. 结论 RSTS 患儿主要临床表现为先天性巨结肠, 颅面畸形, 双侧拇指及踇趾宽大, 生长迟 滞及智力及运动发育迟缓, 在16号染色体CREBBP基因外显子存在c. 2911A>G (p. R971G) 杂合突变. 临床表现结 合CREBBP基因突变可明确 RTST 诊断. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to judge the stability of surrounding rock of underground powerhouse of hydropower station, a detrend fluctuation analysis ( DFA) was proposed to construct a criterion to judge the deformation trend of surrounding rock and then to judge its stability. According to the deformation monitoring data of surrounding rock of a pumped storage power station, the time series were divided into periods, and then the deformation trend of surrounding rock displacement time series and rate time series was judged by non trend fluctuation analysis metlux-1 from the whole and subsection respects. As the Auxiliary Criterion of Hydropower Station Powerhouse Design Specification, the stability of surrounding rock was m1alyzcd m1d compared with the method is reasonable and effective, and the analysis results of cumulative period more regular and there differences compared with the uniform period, that is, the analysis method has a cet1ain influence on the results. [ABSTRACT FROM AUTHOR]

The transmission path of vibration difficult to determine has posed a great threat to the safe operation of water transmission pipeline, due mainly to the complex structure of pump station pipeline, where there are many vibration sources. In this study, an attempt was made to analyze the pipeline transfer path characteristics of pumping stations using transfer entropy. The pipeline of 7 pump stations in an irrigation area was also taken as the research object. Firstly, a prototype test was carried out to obtain the spectrum diagram, and energy proportion, thereby analyzing the main vibration source of pipeline vibration. Then, a transmission entropy method was used to identify the vibration transmission path of the main vibration source in the pump station pipeline under various working conditions. The effectiveness of the pipeline vibration transmission path was finally verified when taking the information transmission rate as the quantitative standard. The results show that: 1) The main vibration source was caused by the blade frequency and frequency doubling in the pipeline, mainly transmitting from the elbow and tee pipe to other parts when the pumping station unit operated stably. Furthermore, the average information transmission rate was 27.2%. More importantly, the transmission rate was relatively low during stable operation, mainly because the anchor block, buttress, and other devices played a critical role in the vibration reduction and energy dissipation. 2) The main vibration source was also caused by the blade frequency in the pipeline, mainly transmitted from the elbow and tee to other parts of the pipeline, when the pump station unit starting up. The average information transmission rate was 42%. It was found that a large part of the energy at the elbow and tee was transmitted to other parts of the pipeline during startup. 3) The main vibration source was the high-frequency vibration caused by low-frequency water flow pulsation and pipe water coupling in the pipeline when the pump station unit was shut down. The vibration was mainly transmitted periodically between the valve, elbow, and tee. The average information transmission rate was 51.4%. It can be seen that a large part of the energy from the valve, elbow, and tee was transmitted to other parts of the pipeline. Correspondingly, the information transmission rate of each working condition showed that a large part of vibration energy at the pipeline valve, elbow, and tee pipe was still transmitted to other parts. Whether the machine was switched on or off, the energy transmitted by the pipeline during the stable operation was less under the control of vibration reduction measures, such as anchor block. Therefore, the prototype observation data was selected to analyze the source of vibration through the spectrum diagram and energy proportion, where quantitatively determine the transmission relationship between vibration from the perspective of energy with the help of transmission entropy and information transmission rate, as well as the direction of vibration transmission. It was more efficient and intuitive than before, indicating great advantages in the application of vibration transmission path recognition. Consequently, this research can greatly contribute to accurately identify the vibration transmission path of the main vibration source in the pump station pipeline, thereby identifying the dangerous parts of the pipeline under different working conditions, where the vibration reduction measures can be further proposed. This finding can provide a promising theoretical basis for the operation and management of the pump station pipeline [ABSTRACT FROM AUTHOR]

Copyright of Ordnance Industry Automation is the property of Editorial Board for Ordnance Industry Automation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Advanced Engineering Science / Gongcheng Kexue Yu Jishu is the property of Advanced Engineering Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Guilin University of Technology is the property of Journal of Guilin University of Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of long non-coding RNA（lncRNA）human plasmacytoma variant translocation 1（PVT1）on the proliferation，invasion and migration of prostate cancer cells. Methods Human prostate cancer cells DU145 and human normal prostate epithelial cells RWPE-1（hereinafter referred to as DU145 and RWPE-1 cells，respectively）were subcultured. RT-qPCR was used to detect the expression of lncRNA PVT1 mRNA in DU145 and RWPE-1 cells. The DU145 cells were randomly divided into the observation group and control group. They were transfected with lncRNA PVT1 siRNA and Negative Control siRNA，respectively. The stable transfected cell line was screened by G418. The expression of lncRNA PVT1 mRNA was detected by RT-qPCR，and the expression of lncRNA PVT1 protein was detected by Western blotting. The MTT method was used to detect the cell proliferation activity of cells cultured for 12，24，36，48，60，72 h，the Transwell chamber test was used to detect the cell invasion ability，and the cell Scratch test was used to detect the cell migration ability. Results The relative expression of lncRNA PVT1 mRNA in DU145 cells was significantly higher than that in RWPE-1 cells（t=7. 938，P<0. 01）. The relative expression levels of lncRNA PVT1 mRNA and protein in the observation group were lower than those in the control group（t=5. 053 and 18. 110，respec⁃ tively，both P<0. 01）. The cell proliferation activity of the observation group was lower than that of the control group at 60 and 72 hours of culture（both P<0. 01），but there was no statistically significant difference in cell proliferation activity between the two groups when the cells were cultured for 12，24，36，and 48 h（all P>0. 05）. The number of transmem⁃ brane cells and cell migration rate in the observation group were lower than those in the control group（t=6. 982 and 11. 782，respectively；both P<0. 05）. Conclusion The expression of lncRNA PVT1 in the prostate cancer cells is high⁃ ly expressed，and down-regulating the expression of lncRNA PVT1 can inhibit the proliferation，invasion and migration of prostate cancer cells. [ABSTRACT FROM AUTHOR]

Copyright of Advanced Engineering Science / Gongcheng Kexue Yu Jishu is the property of Advanced Engineering Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Technology is the property of Journal of Beijing University of Technology, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Advanced Engineering Science / Gongcheng Kexue Yu Jishu is the property of Advanced Engineering Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Mechanics / Gongcheng Lixue is the property of Engineering Mechanics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Technology is the property of Journal of Beijing University of Technology, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Zhengzhou University: Engineering Science is the property of Editorial Office of Journal of Zhengzhou University: Engineering Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Natural Resources / Ziran Ziyuan Xuebao is the property of Journal of Natural Resources and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Over the past few decades, the research into and application of hyperspectral images has made significant progress, with interest levels progressing from very little to intense.Among the many aspects of this research, hyperspectral image classification has become one of the most-studied topics,with experiments showing that the spatial spectral joint classification method can achieve better classification results than the pixel-by-pixel classification method that relies on spectral information alone. Here, we classified and analyzed a number of spatial spectral joint classification methods.First,we introduced two kinds of spatial dependence relations between adjacent pixels in hyperspectral images; using these, we were able to classify existing spatial-spectral classification methods into fixed-dependent neighborhood-based and adaptive neighborhood-based types. In addition, we were able to further divide existing methods into two types, single-dependency and double-dependency, based on whether or not we used two types of dependencies at the same lime. We were also able to divide existing classification methods into three types: preprocessing, integration, and post-processing, according to the different fusion stages of the spatial and spectral information. Finally, we showed the classification results achieved from the application of several representative spatial-spectral classification methods to real hyperspectral datasets. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Zhejiang University (Science Edition) is the property of Journal of Zhejiang University (Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Technology is the property of Journal of Beijing University of Technology, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

反复种植失败(recurrent implantation failure，RIF)是限制辅助生殖技术发展的瓶颈。目前RIF 的诊断标准仍不统一，本文通过查阅文献，归纳整理出2005年以来RIF的诊断标准共12种，从移植胚胎周期 数、移植胚胎数量及质量、移植胚胎期别与周期类型、年龄4方面争议问题进行综述。移植胚胎周期数上有2、 3、4、5、6个周期的不同，主要是2个周期和3个周期的争议，并且呈现逐渐减少趋势;移植胚胎数目上有3、4、5、 8、10个的不同，亦呈逐渐减少趋势;通过形态学或延时摄影技术挑选优质卵裂期胚胎或囊胚进行移植;移植 周期类型包括新鲜胚胎移植和冷冻胚胎移植;年龄通过影响卵巢功能、胚胎质量等方面影响妊娠率、妊娠结 局，故应有所限制。目前较为公认的RIF定义为年龄小于40岁，移植3个周期(包括新鲜胚胎移植和冻融胚胎移 植），个及以上优质胚胎，未获得妊娠的不孕女性。诊断标准的不统一阻碍了 RIF治疗方式的进步，因此开展 高质量的研究，制定并推广规范标准化的RIF诊断标准迫在眉睫。 [ABSTRACT FROM AUTHOR]

In view of the inefficiency problem, of the cache replacement strategy for current content-centric networks, we propose a cache replacement algorithm based on potential energy cooling (PEC-Rep), which combines the "natural coding" phenomenon with the reference of the concept of "potential energy". The PEC-Rep can evaluate content value according to the access number and time interval. And it deletes the content with the minimum value when it performs content replacement so that the node can maintain maximum value to satisfy the subsequent requests of users. Simulation results show that the PEC-Rep can effectively improve the domain-cache hit ratio, reduce the server load and improve the overall performance of the CCN. [ABSTRACT FROM AUTHOR]

Copyright of Tunnel Construction / Suidao Jianshe (Zhong-Yingwen Ban) is the property of Tunnel Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Heilongjiang University of Science & Technology is the property of Journal of Heilongjiang University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Preventive Veterinary Medicine / Zhongguo Yufang Shouyi Xuebao is the property of Chinese Journal of Preventive Veterinary Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to solve the issue of incomplete test information and diagnostic accuracy in the damage diagnosis of arch dam, the information fusion technique of DS (Dempster Shafer) evidential reasoning was introduced to fuse the diagnosis results of multiple damage detection based on statistical model. First, the dynamic response data from pre and post damaged arch dam were obtained and modeled as ARMA (Auto Regressive Moving-Average) models, while a principal component matrix was derived from the AR parameters by the process of feature extraction. Then, draw mean control chart and calculate the Mahalanobis distance between the principal component matrix of pre and post damaged. Make the discriminate results of two diagnostic indexes probabilistic respectively and calculate their composite Mass function. Then the damage and non damage reliability interval were calculated to diagnose the damage of arch dam. The results of simulation experiment of Laxiwa arch dam show that the fusion of DS evidential reasoning can effectively improve the damage diagnosis effect compared with the single damage discriminate results. [ABSTRACT FROM AUTHOR]

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)