127 results on '"Çam M"'
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52. Comparison of chemical characteristics of fresh and pasteurised juice of gilaburu (Viburnum opulusL.)
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Çam, M., primary and Hişil, Y., additional
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- 2007
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53. Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property
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Guy A. Higgins, Nicole K. Carroll, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel, Julia Izhakova, Lilia Magomedova, Ines DeLannoy, and Edward M. Sellers
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psilocybin ,motivation ,depression ,ketamine ,microdose ,attention ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Long term benefits following short-term administration of high psychedelic doses of serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, support their potential as treatments for psychiatric conditions such as major depressive disorder. The high psychedelic doses induce perceptual experiences which are associated with therapeutic benefit. There have also been anecdotal reports of these drugs being used at what are colloquially referred to as “micro” doses to improve mood and cognitive function, although currently there are recognized limitations to their clinical and preclinical investigation. In the present studies we have defined a low dose and plasma exposure range in rats for both ketamine (0.3–3 mg/kg [10–73 ng/ml]) and psilocybin/psilocin (0.05–0.1 mg/kg [7–12 ng/ml]), based on studies which identified these as sub-threshold for the induction of behavioral stereotypies. Tests of efficacy were focused on depression-related endophenotypes of anhedonia, amotivation and cognitive dysfunction using low performing male Long Evans rats trained in two food motivated tasks: a progressive ratio (PR) and serial 5-choice (5-CSRT) task. Both acute doses of ketamine (1–3 mg/kg IP) and psilocybin (0.05–0.1 mg/kg SC) pretreatment increased break point for food (PR task), and improved attentional accuracy and a measure of impulsive action (5-CSRT task). In each case, effect size was modest and largely restricted to test subjects characterized as “low performing”. Furthermore, both drugs showed a similar pattern of effect across both tests. The present studies provide a framework for the future study of ketamine and psilocybin at low doses and plasma exposures, and help to establish the use of these lower concentrations of serotonergic and dissociative hallucinogens both as a valid scientific construct, and as having a therapeutic utility.
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- 2021
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54. he Attitudes Nurses Working at Psychiatric Hospitals in Turkey have towards Forensic Psychiatric Patients and the associated Factors.
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BAYSAN ARABACI, Leyla and ÇAM, M. Olcay
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NURSES' attitudes ,PSYCHIATRIC hospitals ,PSYCHOTHERAPY patients ,FORENSIC psychiatric nursing ,CROSS-sectional method ,EMPLOYMENT ,PSYCHIATRIC nurses - Abstract
Objective: To determine the attitudes nurses working at psychiatric hospitals in Turkey have towards forensic psychiatric patients and the associated factors. Materials and Methods: This cross-sectional study included 620 nurses working at 8 psychiatric hospitals in Turkey that completed =80% of the Nurses' Attitudes Towards Forensic Psychiatric Patients Scale (NAFPPS). Data were evaluated based on number-percentage distribution, and the relationship between variables was examined via t-test, variance analysis, and correlation analysis. Results: Mean age of the nurses was 34.37 ± 7.48 years and 79.4% were female. Mean NAFPPS total and subscale scores were as follows: Xtotal = 69.07 ± 12.46 (max: 125); X feeling threatened = 15.98 ± 3.61 (max: 30); X trust = 20.49 ± 5.24 (max: 20); X social distance = 10.45 ± 3.33 (max: 20); X willingness to provide care = 22.31 ± 4.25 (max: 40). Gender, place of employment, method of obtaining current position, employment status, level of satisfaction working as a psychiatric nurse, history of providing treatment to forensic psychiatric patients, having knowledge of Turkish laws regarding the treatment of forensic psychiatric patients, and thinking that nurses should treat forensic psychiatric patients were correlated with the nurses' attitudes towards forensic psychiatric patients, whereas age, marital status, place of longest residence, level of education, duration of working in the profession, and duration at current hospital were not. Conclusion: Despite the fact that the nurses working at 8 psychiatric hospitals in Turkey considered forensic psychiatric patients threatening, didn't trust them, and had a tendency to be socially distant with them, they had a moderate level of willingness to provide them proper care. [ABSTRACT FROM AUTHOR]
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- 2013
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55. Türkiye'de Psikiyatri Hastanelerinde Çalışan Hemşirelerin Adli Psikiyatri Hastalarına Yönelik Tutumlarını Etkileyen Faktörler.
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ARABACI, Leyla BAYSAN and ÇAM, M. Olcay
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PSYCHIATRIC hospitals ,PSYCHIATRIC nurses ,FORENSIC psychiatry ,MENTAL illness treatment ,JOB satisfaction ,MARITAL status ,ATTITUDE (Psychology) - Abstract
Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2013
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56. Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research
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Guy A. Higgins, Leo B. Silenieks, Cam MacMillan, Sandy Thevarkunnel, Anna I. Parachikova, Cedric Mombereau, Hanna Lindgren, and Jesper F. Bastlund
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attention ,impulsivity ,plasma exposure ,translation ,attentional deficit hyperactivity disorder ,rat ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents widely studied on cognitive domains including attention and impulsive action in humans. These agents thus represent opportunities for clinical observation to be reinvestigated in the preclinical setting, i.e., reverse translation. The present study investigated each drug in male, Long Evans rats trained to perform either (1) the five-choice serial reaction time task (5-CSRTT), (2) Go/NoGo task, or (3) a progressive ratio (PR) task, for the purpose of studying each drug on attention, impulsive action and motivation. Specific challenges were adopted in the 5-CSRTT designed to tax attention and impulsivity, i.e., high frequency of stimulus presentation (sITI), variable reduction in stimulus duration (sSD), and extended delay to stimulus presentation (10-s ITI). Initially, performance of a large (> 80) cohort of rats in each task variant was conducted to examine performance stability over repeated challenge sessions, and to identify subgroups of “high” and “low” attentive rats (sITI and sSD schedules), and “high” and “low” impulsives (10-s ITI). Using an adaptive sequential study design, the effects of AMP, MPH, ATX, and NIC were examined and contrasting profiles noted across the tests. Both AMP (0.03–0.3 mg/kg) and MPH (1–6 mg/kg) improved attentional performance in the sITI but not sSD or 10-s ITI condition, NIC (0.05–0.2 mg/kg) improved accuracy across all conditions. ATX (0.1–1 mg/kg) detrimentally affected performance in the sITI and sSD condition, notably in “high” performers. In tests of impulsive action, ATX reduced premature responses notably in the 10-s ITI condition, and also reduced false alarms in Go/NoGo. Both AMP and NIC increased premature responses in all task variants, although AMP reduced false alarms highlighting differences between these two measures of impulsive action. The effect of MPH was mixed and appeared baseline dependent. ATX reduced break point for food reinforcement suggesting a detrimental effect on motivation for primary reward. Taken together these studies highlight differences between AMP, MPH, and ATX which may translate to their clinical profiles. NIC had the most reliable effect on attentional accuracy, whereas ATX was reliably effective against all tests of impulsive action.
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- 2020
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57. Psikiyatri Hastalarına Yönelik Hemşire Tutum Ölçegği Geliştirme.
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BAYSAN ARABACI, Leyla and ÇAM, M. OIcay
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STATISTICAL correlation , *EXPERIMENTAL design , *FOCUS groups , *FORENSIC psychiatry , *RESEARCH methodology , *NURSES' attitudes , *PSYCHIATRIC nursing , *STATISTICS , *PRE-tests & post-tests , *INTER-observer reliability , *RESEARCH methodology evaluation ,RESEARCH evaluation - Abstract
Objective: This research was performed methodologically in order to develop a scale for examining the nurses' attitudes towards forensic psychiatric patients and to determine the validity and reliability of the scale. Method: The research was carried out with 650 nurses accepted to participate in the research. Evaluation of the data was done on 536 questionnaires. In the research, Information Form, the Belief Towards Mental Illness Scale (BMIS) and the Nurses' Attitude Towards Forensic Psychiatric Patients Scale (NAFPPS) were used. NAFPPS was developed in two processes as qualitative (theoretical) and quantitative. In the qualitative process, "focus group discussion", "composition forms" and various attitude scales published in the literature were applied. In the quantitative process, validity and reliability analysis was performed. Results: Content validity index (CVI) was found to be 0.69 and concurrent validity with BMIS was 0.44. The Cronbach's Alpha coefficient determining the internal consistency was 0.86, intracluster correlation coefficient was 0.86, and stability factor determining the consistency between pre-test and re-test 0.69. It was observed that NAFPPS consisted of four subdimensions. The highest score that can be achieved on the scale is "125", the lowest one is "25". High score shows the positive attitude towards the forensic psychiatric patient. Discussion: In the light of these data, the NAFPPS was found to be valid and reliable. [ABSTRACT FROM AUTHOR]
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- 2011
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58. Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins.
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Çam, M., Handke, W., Picard-Maureau, M., and Brune, W.
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APOPTOSIS , *VIRUS diseases , *PROTEINS , *CYTOMEGALOVIRUSES , *VIRAL proteins - Abstract
Apoptosis of infected cells can limit virus replication and serves as an innate defense mechanism against viral infections. Consequently, viruses delay apoptosis by expressing antiapoptotic proteins, many of which structurally resemble the cellular antiapoptotic protein Bcl-2. Like Bcl-2, the viral analogs inhibit apoptosis by preventing activation and/or oligomerization of the proapoptotic mitochondrial proteins Bax and Bak. Here we show that cytomegaloviruses (CMVs) have adopted a different strategy. They encode two separate mitochondrial proteins that lack obvious sequence similarities to Bcl-2-family proteins and specifically counteract either Bax or Bak. We identified a small mitochondrion-localized protein encoded by the murine CMV open reading frame (ORF) m41.1, which functions as a viral inhibitor of Bak oligomerization (vIBO). It blocks Bak-mediated cytochrome c release and Bak-dependent induction of apoptosis. It protects cells from cell death-inducing stimuli together with the previously identified Bax-specific inhibitor viral mitochondria-localized inhibitor of apoptosis (vMIA) (encoded by ORF m38.5). Similar vIBO proteins are encoded by CMVs of rats, and possibly by other CMVs as well. These results suggest a non-redundant function of Bax and Bak during viral infection, and a benefit for CMVs derived from the ability to inhibit Bak and Bax separately with two viral proteins. [ABSTRACT FROM AUTHOR]
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- 2010
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59. Effect of epidermal growth factor on rabbit urethral healing
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Aǧartan, C. A., tanju aktuğ, Güven, A., Demir, D., Öner, F., and Çam, M.
60. HEMŞİRELİK YÜKSEK OKULU ÖGRENCİLERİNDE PSİKODRAMA GRUP ÇALIŞMASI İLE GİRİŞKENLİK DÜZEYİ İLİŞKİSİNİN İNCELENMESİ
- Author
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Kırlangıç-ÇAM, M. Olcay
- Abstract
Bu çalışma, yaşamdan doyum sağlamak için, bireylerin sahip olması gereken önemli bir nitelik olarak, girişkenlik özelliğine, bir grup hemşirelik yüksek okulu öğrencisinin ne düzeyle sahip olduğunu saptamak ve psikodrama grup çalışmaları ile öğrencilerin girişkenlik düzeyinde bir değişme oluşup, oluşmadığını belirlemek amacıyla yapılmıştır
61. HEMŞİRELİK YÜKSEK OKULLARINDA GÖREVLİ EĞİTİMCİLERİN YAŞADIKLARI ÇEŞİTLİ DUYGU VE DÜŞÜNCELERİN İNCELENMESİ
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ÇAM, M Olcay
- Abstract
Bu çalışma, hemşirelik yüksek okullarında görevli eğitimcilerin, emosyonel tükenme, duyarsızlaşma, kişisel başarı duyumuyla ilgili duyguları ile iş yaşantısı içindeki çeşitli konulardaki görüş ve düşüncelerini incelemek amacıyla yapılmıştır. Sonuç olarak, eğitimci hemşireler emosyonel tükenme ile ilgili duyguları orta düzeylerdeki sıklıklarla, duyarsızlaşma ile ilgili duyguları düşük düzeylerdeki sıklıklarla, kişisel başarı ile ilgili duyguları yüksek düzeylerdeki sıklıklarla yaşamaktadırlar. Eğitimci hemşirelerin çoğu belirli bir sürede bir çok işi olduğu duygusunu, zaman baskısını, yapabileceğinden fazlasını yaptığı duygusunu, istemediği işleri yaptığı duygusunu yaygın bir şekilde yaşamaktadırlar. Eğitimci hemşireler için, öğrenci eğitiminde önem verilmesi gereken yönler şunlardır: Nitelikli eğitim, meslek bilinci ve sevgisi, öğrencilerin kişilikleri, teorik bilgi, insan sevgisi, uygulamalara önem verilmesidir, The purpose of this study, was to determine how frequently the nursing educators academic members experierıced emotıonal exhaustıon. depersonalization and personal accomplishment. and to ınvestıgate theır opinions about different fields of their professional life. in conlusion. they were found to experience emotiorıal exhaustion in midfrequency. depersonalization in Icw-frequency and personal accomplishment in high frequency levels. On the other harıd. majority of the nursing educators were found to experience "time pressure", the feeling of "having too many dtffererıt tasks to do in a specıflc period", the feeling of "doing more than they can". and the feelings of "doing tasks that they do not want eagerly". Below are tlıe main points that the academic members must corısider in nursing education: "Qualifıed educatiorı". "The consciousness and love professton" "Personal developments of studerıts", "humantsm", "theoretical knowledge" and "practıcal hints''.
62. HEMŞİRELİK YÜKSEK OKULU ÖĞRENCİLERİNDE PSİKODRAMANIN EMPATİK EĞİLİM VE EMPATİK BECERİ ÜZERİNE ETKİSİ
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ÇAM, M Olcay
- Abstract
Bu çalışma, Hemşirelik Yüksek Okulu öğrencilerinin empati eğilimi ve empati beceri düzeylerini belirlemek ve psikodrama grup çalışmaları ile empati eğilim ve beceri düzeylerinde bir değişiklik oluşup oluşmadığını saptamak amacıyla yapılmıştır. Araştırma sonucunda, empati eğilimi ve empati beceri puanlarında, oluşan artışın düşük düzeyde olduğu saptanmıştır. Bu artış, istatistiksel olarak anlamlılık göstermemiştir.
63. ÖGRENCİLERİN MADDE BAĞIMLILIĞI DERSİ KONUSUNDAKİ GÖRÜŞLERİ
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KIRLANGIÇ ÇAM, M. Olcay
64. RECOVERY FOR PEOPLE WITH MENTAL HEALTH PROBLEMS AND MENTAL HEALTH NURSES
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ÇAM, M Olcay and AYDOĞDU DURMUŞ, Hilal
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İyileşme,ruhsal hastalık,psikiyatri hemşireliği ,Recovery,mental health problems,psychiatry nursing - Abstract
Recovery is a concept that is discussed frequently recently. This is not a new concept for mental health, although there is not a universal definition. In terms o f the health care team, recovery m eans symptom control a nd psychosocial functions, while for people positive behaviors with mental illness involves the renewal of self a nd re-discovery o f a long journey. That can vary depending on people with mental health problems a nd health care team concept. The role of psychiatric nurses in the recovery starts with listening to the life experiences of people. At this point capture the com m on m eaning of recovery is important. Recovery tried to explain with m any models a nd tools. But there is no com m on recovery model, theory or tool that can measure it. Therefore, this article, reviewing recovery perspectives of people with mental health problems andpsychiatric nurses on the concept of recovery in mental health a nd their role in the recovery process, models a nd tools for developed to assess the recovery was written, iyileşme, son zamanlara sıkça gündeme gelen bir kavramdır. Ruh sağlığında yeni bir kavram olmamasına rağmen evrensel bir tanımı yoktur. Sağlık ekibi açısından, semptomları kontrol altında tutmayı ve psikososyal fonksiyonların yenilenmesini içerirken ruh hastalığı olan bireyler açısından olumlu davranışları ve kendini yeniden bulmayı içeren uzun bir yolculuktur. Ruhsal hastalığı olan bireylere ve sağlık ekibine göre değişebilen bir kavramdır. Psikiyatri hemşirelerinin iyileşmedeki rolü bireylerin yaşam deneyimlerini dinleme ile başlar. Bu noktada iyileşmede ortak anlamı yakalamak önem kazanmaktadır. İyileşme, birçok modelle açıklanmaya ve birçok araçla değerlendirilmeye çalışılmıştır. Fakat ortak bir iyileşme modeli, teorisi ya da iyileşmeyi ölçebilen bir araç bulunmamaktadır. Bu nedenle bu makale, ruhsal hastalığı olan bireylerin ve psikiyatri hemşirelerinin ruh sağlığında iyileşme kavramına bakış açılarını ve iyileşme sürecindeki rollerini, iyileşmeyle ilgili geliştirilen modelleri ve iyileşmeyi değerlendirmek için geliştirilen araçları gözden geçirmek amacıyla yazılmıştır
65. HEMŞİRELERİN, FARKLI KLİNİK TABLOYA SAHİP ÇEŞİTLİ RUH HASTALARI İLE İLGİLİ TUTUMLARI
- Author
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KIRLANGIÇ ÇAM, M. Olcay
- Abstract
Araştırma, Manisa Ruh Sağlığı ve Hastalıklar/ Hastanesi'nde hemşirelerin çeşitli ruh hastalarına karşı tutumlarını saptamak amacıyla yapılmıştır. Veriler görüşme tekniğiyle toplanmıştır. Görüşmeler yan yapılandırılmış olup. teketek görüşme şeklinde yapılmıştır. Elde edilen yerlerin değerlendirilmesiyle, hemşirelerin hastalarına karşı yeterince, uygun ve terapötik tutum göstermedikleri görülmiiştür., The purpose of this study was to examine to attitudes of the nurses against to mentally The data was collected frorn nurses N=59 Manisa Mental Hospital by use of Savaşır's attitude forms in 1984. When the data was analyzed. we were aware of these : 1. The nurses haven'te enough theoretical and practical knowledge about different mentally ills. 2. The nurses haven't enough exhibited therapeutie attitudes to the patients. Therefore, some implieations were suggested; - The nurses must be ehosen according to their personalities and their motivations to work of this fields. - The nurses must be giyen a training program before they begin to work. - The nurses must have in-servise edueation and they must be süpervised
66. HEMŞİRELERİN RUH HASTALIĞI İLE İLGİLİ TUTUMLARININ ARAŞTIRILMASI
- Author
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KIRLANGIÇ (ÇAM)., M. Olcay
- Abstract
Araştırma, Manisa Ruh Sağlığı ve Hastalıkları Hastanesi'nde hemşirelerin ruh hastalığına karşı tutumlarını saptamak amacıyla, betimleylci tarzda yapılmıştır. Veriler, görüşme tekniğiyle elde edilmiştir. 59 hemşire ile teketek görüşme yapılmıştır. Elde edilen velilerin değerlendirilmesiyle, hemşirelerin ruh hastalığı ile ilgili tuturnlarımn, toplumsal yapı ile paralellik gösterdiği be - lirlenmiştir. WHO, dünyada 40 milyon civarında ağır ruh hastası olduğunu bildirmiştir. Bu rakam, ruh sağlığının korunup , sü rü dü rü 1.rn est konusundaki çalışmalann gerekliliğinin ve öneminin bir göstergesidir 10 . Ruh hastalarına götürülen sağlık hizeti bir ekip hizmetidir. Ekip üyelerinin birlikte, uyum içinde, uygun ve tutarlı bir şekilde hastaya yaklaşmaları hastaya sağlanan yararı birkaç kez arttırmaktadır. Ekipte, psikiyatri hernşiresinin önemi, hastayla sürekli ve daha uzun süreli birlikte olabilmek konunuyla artmaktadır 1, 14 . Hasta bireylerin olumlu benlik kavrakı geliştirip etkin kişiler arası ilişkiler kura - bilmesi ve toplumada üretici rol alabilmele rinin sağlanması, psikiyatri hemşireliğinin tanırnıffir 2', 4, 7, 8 . ülkemizde hemşirelik alanında uzrnanlaşmalar yeni yeni oluşmaktadır. Bu nedenle, ruh sağlığı ve hastalıkları alanındaki hemşire lik hizmetleri uzrnanlaşrnamış hemşireler tarafından yürütülmektedir. Bu araştırma, mevcut koşullarımızla birlikte, hemşirelerimizin ruh hastalığı ile ilgili tutumlannın saptanması amacıyla yapılmıştır., This study is done at the Manisa Mental Hospital to determine the nurses' attitudes to mental illness. There are 400 beds in this hospital . Interview technique is ıisud and the data is gathered by this technique. The statistical analysis of data showed that the nurses' attitudes weren't appropriate for therapeutic change. Nurses' attitudes vere similiar of the other people of our community.
67. Conduction in ulnar nerve bundles that innervate the proximal and distal muscles: a clinical trial
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Oğuzhanoğlu Attila, Güler Sibel, Çam Mustafa, and Değirmenci Eylem
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background This study aims to investigate and compare the conduction parameters of nerve bundles in the ulnar nerve that innervates the forearm muscles and hand muscles; routine electromyography study merely evaluates the nerve segment of distal (hand) muscles. Methods An electrophysiological evaluation, consisting of velocities, amplitudes, and durations of ulnar nerve bundles to 2 forearm muscles and the hypothenar muscles was performed on the same humeral segment. Results The velocities and durations of the compound muscle action potential (CMAP) of the ulnar nerve bundle to the proximal muscles were greater than to distal muscles, but the amplitudes were smaller. Conclusions Bundles in the ulnar nerve of proximal muscles have larger neuronal bodies and thicker nerve fibers than those in the same nerve in distal muscles, and their conduction velocities are higher. The CMAPs of proximal muscles also have smaller amplitudes and greater durations. These findings can be attributed to the desynchronization that is caused by a wider range of distribution in nerve fiber diameters. Conduction parameters of nerve fibers with different diameters in the same peripheral nerve can be estimated.
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- 2010
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68. A detailed transcript-level probe annotation reveals alternative splicing based microarray platform differences
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Cam Margaret C, Lu Jun, Stiles David, and Lee Joseph C
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Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Microarrays are a popular tool used in experiments to measure gene expression levels. Improving the reproducibility of microarray results produced by different chips from various manufacturers is important to create comparable and combinable experimental results. Alternative splicing has been cited as a possible cause of differences in expression measurements across platforms, though no study to this point has been conducted to show its influence in cross-platform differences. Results Using probe sequence data, a new microarray probe/transcript annotation was created based on the AceView Aug05 release that allowed for the categorization of genes based on their expression measurements' susceptibility to alternative splicing differences across microarray platforms. Examining gene expression data from multiple platforms in light of the new categorization, genes unsusceptible to alternative splicing differences showed higher signal agreement than those genes most susceptible to alternative splicing differences. The analysis gave rise to a different probe-level visualization method that can highlight probe differences according to transcript specificity. Conclusion The results highlight the need for detailed probe annotation at the transcriptome level. The presence of alternative splicing within a given sample can affect gene expression measurements and is a contributing factor to overall technical differences across platforms.
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- 2007
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69. Transcript-based redefinition of grouped oligonucleotide probe sets using AceView: High-resolution annotation for microarrays
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Cam Margaret C, Salit Marc L, Lee Joseph C, and Lu Jun
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Extracting biological information from high-density Affymetrix arrays is a multi-step process that begins with the accurate annotation of microarray probes. Shortfalls in the original Affymetrix probe annotation have been described; however, few studies have provided rigorous solutions for routine data analysis. Results Using AceView, a comprehensive human transcript database, we have reannotated the probes by matching them to RNA transcripts instead of genes. Based on this transcript-level annotation, a new probe set definition was created in which every probe in a probe set maps to a common set of AceView gene transcripts. In addition, using artificial data sets we identified that a minimal probe set size of 4 is necessary for reliable statistical summarization. We further demonstrate that applying the new probe set definition can detect specific transcript variants contributing to differential expression and it also improves cross-platform concordance. Conclusion We conclude that our transcript-level reannotation and redefinition of probe sets complement the original Affymetrix design. Redefinitions introduce probe sets whose sizes may not support reliable statistical summarization; therefore, we advocate using our transcript-level mapping redefinition in a secondary analysis step rather than as a replacement. Knowing which specific transcripts are differentially expressed is important to properly design probe/primer pairs for validation purposes. For convenience, we have created custom chip-description-files (CDFs) and annotation files for our new probe set definitions that are compatible with Bioconductor, Affymetrix Expression Console or third party software.
- Published
- 2007
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70. Numerical simulation of raindrop spectra: Effects of vertical differential advection of raindrops
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Le Cam, M.-N. and Isaka, H.
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- 1989
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71. Sur les variations de quelques activités enzymatiques dans le globule rouge humain, au cours de diverses circonstances physiologiques et pathologiques
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Bernard, S., Dubin, J.C., Madec, Y., and Le Cam, M.
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- 1966
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72. Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats
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Dicle KARGIN, Şule AKTAÇ, Ayse Nur HAZAR YAVUZ, Muhammet Emin ÇAM, and Karğın D., Aktaç Ş., Yavuz A. N., Çam M. E.
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Nutrition and Dietetics ,antioxidant ,Cornus mas L ,NUTRITION & DIETETICS ,Beslenme ve Diyetetik ,Agriculture & Environment Sciences (AGE) ,Sağlık Bilimleri ,liver ,high-fat-diet ,Clinical Medicine (MED) ,BESLENME VE DİYETETİK ,AGRICULTURAL SCIENCES ,Health Sciences ,Tarım Bilimleri ,Beslenme ve Dietetik ,Klinik Tıp (MED) ,Tarım ve Çevre Bilimleri (AGE) ,glutathione - Abstract
Cornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult Sprague Dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post-treated with C. mas (200 mg/kg/day; 4 weeks), HFD posttreated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH), and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats.
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- 2023
73. Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats
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Busra Ertas, Ayse Nur Hazar-Yavuz, Fadime Topal, Rumeysa Keles-Kaya, Özge Karakus, Gul Sinemcan Ozcan, Turgut Taskin, Muhammet Emin Cam, and ERTAŞ B., YAVUZ A. N., Topal F., Keles-Kaya R., Karakus Ö., Ozcan G. S., TAŞKIN T., ÇAM M. E.
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Farmakoloji ,Life Sciences (LIFE) ,Molecular Biology and Genetics ,Sağlık Bilimleri ,BİYOKİMYA VE MOLEKÜLER BİYOLOJİ ,Yaşam Bilimleri ,Health Sciences ,Drug Discovery ,FARMAKOLOJİ VE ECZACILIK ,Cytogenetic ,Type-2 diabetes mellitus ,Eczacılık ,PHARMACOLOGY & PHARMACY ,Moleküler Biyoloji ve Genetik ,Pharmacology ,PHARMACOLOGY & TOXICOLOGY ,İlaç Keşfi ,Temel Bilimler ,Basic Pharmaceutics Sciences ,Life Sciences ,Alzheimer's disease ,Pharmacology and Therapeutics ,MOLECULAR BIOLOGY & GENETICS ,Insulin signaling ,Cognitive impairment ,Temel Eczacılık Bilimleri ,Yaşam Bilimleri (LIFE) ,Farmakoloji ve Toksikoloji ,Natural Sciences ,BIOCHEMISTRY & MOLECULAR BIOLOGY ,Sitogenetik - Abstract
Ethnopharmacological relevance: Recent studies claim that Type-2 diabetes mellitus (T2DM) and Alzheimer\"s disease (AD) overlap in several common pathological pathways which from neuronal damage to impaired memory performance. It is known that the use of Rosa canina L. (R. canina) as medicine in folk medicine dates back to ancient times and is used in the treatment of nervous diseases in Persian medicine. However, the effect of R. canina on diabetes-related cognitive decline and memory impairment has not yet been studied. Aim of the study: We evaluated the impact of T2DM on AD-like alterations and examined the molecular mechanism of a possible effect of R. canina on cognitive alterations in diabetic rats. Materials&methods: R. canina ethanol extract was obtained by maceration method. This study was performed with male Sprague-Dawley rats fed with a high-fat diet (HFD) for 8 weeks, low-dose streptozotocin (STZ; 35 mg/kg IP) injection for 4 weeks, and R. canina (250 mg/kg; per oral) and metformin (400 mg/kg; per oral) administration for 4 weeks. The weight and blood glucose of rats were measured weekly. To evaluate glucose tolerance area under the curve (AUC) was calculated by performing an oral glucose tolerance test. Then the rats were subjected to behavioural tests, and their hippocampus and cortex tissues were obtained for biochemical and morphological analyses. Results: R. canina could manage glucose responsiveness by reducing post-prandial blood glucose levels, preventing weight loss, and raising serum insulin levels in T2DM-induced rats. Behavioural tests showed that R. canina significantly improves diabetes-related cognitive decline in recall and long-term memory. Treatment with R. canina significantly reversed HFD/STZ-induced increases in insulin, amyloid-β, amyloid precursor protein levels, and acetylcholinesterase activity in the prefrontal cortex and hippocampus. Furthermore, histological analyzes revealed the protection of R. canina against neuronal disruption in the cortical and hippocampal CA3 region caused by chronic hyperglycemia. Conclusion: Analyzed collectively, these results suggest that R. canina can correct T2DM-related cognitive decline may be attributed to insulin pathway modulation, prevention of amyloid deposition, and increased cholinergic transmission.
- Published
- 2023
74. A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin-Loaded Polycaprolactone/Polylactic Acid Nanofibers
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Saliha Aydin, Ilke Kabaoglu, Ece Guler, Fadime Topal, Ayse Nur Hazar‐Yavuz, Ceyda Ekentok, Esra Tatar, Fatmanur Gurbuz, Oguzhan Gunduz, Muhammet Emin Cam, and Aydin S., Kabaoglu I., Guler E., Topal F., YAVUZ A. N., EKENTOK ATICI C., TATAR E., Gurbuz F., GÜNDÜZ O., ÇAM M. E.
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DRUG-RELEASE ,Characterization of Polymers ,Polymers and Plastics ,SUSTAINED-RELEASE ,General Chemical Engineering ,Temel Bilimler (SCI) ,MATERIALS SCIENCE, MULTIDISCIPLINARY ,POLYMER SCIENCE ,Physical Chemistry ,MATERIALS SCIENCE ,Kimya ,DELIVERY ,MICROSPHERES ,CHEMISTRY ,nanofibers ,Materials Chemistry ,General Materials Science ,curcumin ,MALZEME BİLİMİ, ÇOKDİSİPLİNLİ ,Engineering, Computing & Technology (ENG) ,electrospinning ,Temel Bilimler ,Organic Chemistry ,Polimer Karakterizasyonu ,Metals and Alloys ,Fizikokimya ,Mühendislik, Bilişim ve Teknoloji (ENG) ,General Chemistry ,IN-VITRO ,Alzheimer's disease ,DEGRADATION ,donepezil hydrochloride ,ALZHEIMERS-DISEASE ,POLİMER BİLİMİ ,Chemistry (miscellaneous) ,Natural Sciences (SCI) ,Physical Sciences ,ELECTROSPUN NANOFIBERS ,Engineering and Technology ,Mühendislik ve Teknoloji ,Natural Sciences ,TETRACYCLINE ,Malzeme Bilimi - Abstract
Nanofibers (NFs) offer an alternative option for the treatment of Alzheimer\"s disease (AD) by addressing unmet clinical problems. In this study, anti-AD drugs, donepezil (DO) and curcumin (CUR), are loaded in polylactic acid/polycaprolactone NFs. The effect of fiber diameter on drug release behavior is mainly observed, and the successful loading of DO and CUR to NFs is demonstrated. The tensile strength of DO/CUR-loaded NFs (DNFs) with lower fiber diameter is found to be higher. The working temperature is increased by the decrease of glass transition temperature and increase of the melting temperature after loading drugs. Furthermore, the increase in the percentage of swelling and decrease in the degradation rate for NFs are observed due to the increase of fiber diameter. Encapsulation efficiency and burst release percentages for DNFs are augmented by the increase of fiber diameter. Nevertheless, DNFs exhibit a sustained drug release manner over 2 weeks. NFs do not demonstrate a toxic effect on L929 (mouse fibroblast) cells, and additionally, they promote cell proliferation. Considering all these results, it is proven that the fiber diameter affects all characteristic features of NFs, and DNFs lead to a new and promising drug delivery system for the treatment of AD.
- Published
- 2022
75. Yoğun bakım hemşirelerinin iş yaşam dengesinin incelenmesi
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Babacan, Burcu, Çam, M. Olcay, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
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Psychiatry ,Critical Care ,Intensive care ,Work-Life Balance ,Nurses ,Psychiatric Nursing ,Hemşire ,Nursing ,Hemşirelik ,İş Yaşam Dengesi ,Yoğun Bakım ,Psikiyatri Hemşiresi ,Psikiyatri - Abstract
Giriş: Zamanın getirileri ve günümüzün iş yaşamı koşulları bireyin iş yaşamı ve özel yaşamı arasındaki sınırları tehdit etmektedir. İş yaşamıyla ve özel yaşamla beraber anılandan ayrı bir de “ben” olan insan için denge sağlamak önemlidir. İş yaşamındaki çatışmaların özel yaşama aktarılması, doğasında pek çok zorluk yatan hemşireliğin ve hemşireliğin özellikli bir alanı olan yoğun bakım hemşirelerinin iş yaşam dengesini tartışılır hale getirmiştir. Amaç: Araştırmanın amacı, yoğun bakım hemşirelerinin iş yaşam dengesinin incelenmesidir. Yöntem: Tanımlayıcı ve kesitsel tipte olan araştırmanın evrenini Dokuz Eylül Üniversitesi Hastanesi’nde çalışan 132 yoğun bakım hemşiresi oluşturmuştur (n=114). Yüz yüze görüşme yöntemiyle anket aracılığıyla verilerin toplandığı araştırmada veri toplama aracı olarak sosyodemografik kişisel veri formu ve İş Yaşam Dengesi Ölçeği kullanılmış veriler bağımsız gruplarda tek yönlü varyans analizi, bağımsız iki grup t testi, Mann Whitney U testi, Kruskal-Wallis testi ve çoklu regresyon analizi kullanılarak değerlendirilmiştir. Bulgular: Yoğun bakım hemşirelerinin cinsiyet, eğitim durumu, medeni durum, beraber yaşanılan kişi, çocuk sahibi olma, çocuk sayısı, aylık ortalama mesai saati değişkenlerinin iş yaşam dengesine etkisi incelendiğinde istatistiksel olarak anlamlı fark saptanmazken (p>0.05); yaş, gelir durumu algısı, çalışılan yoğun bakım, yoğun bakımda çalışma süresi, toplam mesleki tecrübe süresi, çalışma düzeni, aylık ortalama mesai saati algısı, ayrılma niyeti değişkenlerinin iş yaşam dengesine etkisinde istatistiksel olarak anlamlı fark saptanmıştır (p, Introduction: The returns of time and today’s working conditions threaten the boundaries between the working life. Apart from work and private life, it is important to adjust the balance of life for the person who is an “individual". Transferring conflicts in working life to private life has made discussable the work and life balance of the nursing which is a difficult profession already and intensive care nursing which is a special part of the nursing. Aim: The aim of the study is to investigate the work and life balance of intensive care nurses. Method: This study which examines the work and life balance of intensive care nurses is descriptive and cross-sectional and the universe of this study includes 132 intensive care nurses working at Dokuz Eylül University Hospital. In this study, 114 intensive care nurses were reached by using face-to-face questionnaire method. Sociodemographic personal data form and Work and Life Balance Scale were used as data collection method. Data were analyzed by using one-way analysis of variance, t test, Mann Whitney U test and Kruskal-Wallis test and multiple regression analysis. Results: There was no statistically significant difference when we look at the effect of the variables of gender, educational status, marital status, living with someone, having children and number of children on work and life balance of intensive care nurses (p>0.05); however we can see statistically significant difference when we look at the income status, age,intensive care unit, shift of work, length of work experience in intensive care unit, monthly average working hours perception, intention to leave the work variables on work and life balance of intensive care nurses (p
- Published
- 2020
76. Process for production of ready to drink iced teas from sage (Salvia officinalis L.) and linden (Tilia cordata): pressurized hot water extraction and spray drying
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Hamza Alaşalvar, Mustafa Çam, Alaşalvar, H., Department of Food Engineering, Faculty of Engineering, Niğde Ömer Halisdemir University, Niğde, 51240, Turkey -- Çam, M., Department of Food Engineering, Faculty of Engineering, Erciyes University, Kayseri, 38039, Turkey, and 0-Belirlenecek
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0106 biological sciences ,Tilia cordata ,Linden ,Pasteurization ,01 natural sciences ,Applied Microbiology and Biotechnology ,Sensory analysis ,Article ,law.invention ,chemistry.chemical_compound ,0404 agricultural biotechnology ,law ,010608 biotechnology ,Food science ,Pressurized hot water extraction ,biology ,Chemistry ,SAGE ,Spray drying ,food and beverages ,04 agricultural and veterinary sciences ,Maltodextrin ,biology.organism_classification ,Sage ,040401 food science ,Hot water extraction ,Citric acid ,Ready to drink iced tea ,Food Science ,Biotechnology - Abstract
The aim of this study was to produce ready to drink (RTD) iced teas from sage and linden. For this purpose, phenolics of sage and linden were extracted by pressurized hot water extraction (PHWE) and then the extracts obtained were spray dried by the addition of maltodextrin. The powders produced by spray drying were processed into RTD sage and linden iced teas by adding sucrose and citric acid. The optimum conditions of PHWE of sage and linden were at 160 °C and for 10 min and 5 min, respectively. The solubility and microencapsulation efficiency of spray dried powders were found to be greater than 97%. In addition, total phenolic content and antioxidant activity of RTD iced teas are parallel with those of microencapsulated sage and linden powders after pasteurization at 80 °C for 5 min. The sensory analysis of RTD iced teas showed that products were well-accepted by the panelists. © 2018, The Korean Society of Food Science and Technology., This research was financially supported by the?Ministry of Science, Industry and Technology, Republic of Turkey under the Project Number of 1483.TGSD.2015.
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- 2019
77. Üniversite öğrencilerinin öfke yönetimine psikodramanın etkisi
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Durmuş, Tuğba, Çam, M. Olcay, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
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Psychiatry ,Psychiatric nursing ,Psikodrama ,Öfke ,University Students ,Nursing ,Anger ,Psychodrama ,Psikiyatri ,Anger Expression ,University students ,Students-nursing ,Nursing Students ,Öğrenci Hemşire ,Anger management therapy ,Anger control ,Expressed emotion ,Üniversite Öğrencisi ,Hemşirelik ,Drama ,Öfke İfade Tarzı - Abstract
Giriş: Araştırmanın amacı, üniversite öğrencilerinin öfke ifade tarzlarına psikodramanın etkisini belirlemektir. Gereç ve Yöntem: Araştırma ön test- son test kontrol gruplu yarı deneysel bir araştırmadır. Araştırmanın evrenini Ege Üniversitesi Hemşirelik Fakültesi'nde kayıtlı N=1554 öğrenci oluşturmuştur. Araştırmanın örneklemini yapılan duyurular sonrası katılıma gönüllü olan ve araştırmaya dahil edilme kriterlerine uyan 21 öğrenci oluşturmuştur. Çalışma uygulama grubunda 11 birey, kontrol grubunda 10 birey ile tamamlanmıştır. Katılımcılar Sürekli Öfke Alt Ölçeği ön test puanlarına göre randomize edilmişlerdir. Veri toplama aracı olarak Tanıtıcı Bilgi Formu, Sürekli Öfke - Öfke İfade Tarzı Ölçeği(SÖÖTÖ), Grup Sonrası Geri Bildirim Formu kullanılmıştır. Verilerin değerlendirilmesi Statistical Package fort the Social Sciences (SPSS) 21 programında yapılmıştır. Sayısal ölçümler için Mann-Whitney U testi kullanılmıştır. Bulgular: Uygulama grubuna on iki oturumluk öfke temalı psikodrama grubu gerçekleştirilmiştir. Uygulama sonrası ölçümlerde uygulama ve kontrol grubunun sürekli öfke, öfke içte, öfke kontrol, öfke dışa alt ölçekleri puan ortalamasının ön test-son test farkları her boyut için ayrı ayrı karşılaştırıldığında istatiksel açıdan anlamlı fark saptanamamıştır(p>0.05). Sonuç: Araştırma sonuçlarına göre hemşirelik öğrencileri ile yürütülen on iki oturumluk öfke temalı psikodrama grubunun bireylerin öfke ifade tarzları üzerinde etkili olduğu saptanmıştır fakat kontrol grubu ile karşılaştırıldığında bu fark istatiksel olarak anlamlı bulunmamıştır. Araştırma sonuçları ilgili alan yazın kapsamında değerlendirilerek, sınırlılıkları belirtilmiştir., Introduction: The aim of this study is to determine the effect of psychodrama on anger expression of university students. Materials and Methods: The study was a quasi-experimental study with a pre-test and post-test control group having a target population of N=1554 students registered in the Ege University Nursing Faculty. The sample consisted of 21 students who met the criteria and volunteered for the study after announcements. The study was completed with 11 individuals in the practice group and 10 individuals in the control group. The participants were randomized according to their State-Trait subscale pre-test scores. Personal Information Form, The State-Trait Anger Expression Inventory (STAXI) and Group Feedback Form were used as data collection devices. The evaluations of data were done in the Statistical Package for the Social Sciences (SPSS) 21 program. Mann-Whitney U test was used for statistical measurement. Findings: Twelve sessions of anger-themed psychodrama group was applied to the practice group. On the post-application measures; when pre-test and post-test score averages for each trait anger, anger in, anger control, anger out subscales were compared, statistically no significant difference was found (p>0.05). Results: According to the results of the study, it was determined that the twelve- sessions of anger-based psychodrama group conducted with nursing student had an impact on anger expressions of individuals but compared with the control group this difference was not statistically significant. The results of the study were evaluated in the scope of literature and their limitations were indicated.
- Published
- 2019
78. Simultaneous extraction of phenolics and essential oil from peppermint by pressurized hot water extraction
- Author
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Mustafa Çam, Murat Yilmaztekin, Abdulatef M. Ahhmed, Esma Yüksel, Hamza Alaşalvar, Osman Sagdic, Hülya Şen, Bülent Başyiğit, 0-Belirlenecek, Arslan Şen, Hülya, and Çam, M., Department of Food Engineering, Faculty of Engineering, Erciyes University, Kayseri, 38039, Turkey -- Yüksel, E., Institute of Natural and Applied Sciences, Erciyes University, Kayseri, 38039, Turkey -- Alaşalvar, H., Department of Food Engineering, Faculty of Engineering, Niğde Ömer Halisdemir University, Nigde, 51240, Turkey -- Başyiğit, B., Department of Food Engineering, Faculty of Engineering, Harran University, Şanlıurfa, 63300, Turkey -- Şen, H., Department of Food Engineering, Faculty of Engineering, Karamanoğlu Mehmetbey University, Karaman, 70100, Turkey -- Yılmaztekin, M., Department of Food Engineering, Faculty of Engineering, İnönü University, Malatya, 44280, Turkey -- Ahhmed, A., Chemical and Metallurgical Engineering Faculty, Food Engineering Department, Yıldız Technical University, İstanbul, 34210, Turkey -- Sağdıç, O., Chemical and Metallurgical Engineering Faculty, Food Engineering Department, Yıldız Technical University, İstanbul, 34210, Turkey
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Fraction (chemistry) ,01 natural sciences ,law.invention ,Hydrolysis ,chemistry.chemical_compound ,Peppermint ,0404 agricultural biotechnology ,law ,Eriocitrin ,Pressurized hot water extraction ,Essential oil ,Chromatography ,Chemistry ,010401 analytical chemistry ,Extraction (chemistry) ,04 agricultural and veterinary sciences ,040401 food science ,0104 chemical sciences ,Hot water extraction ,Menthol ,Spray drying ,Original Article ,Phenolics ,Food Science - Abstract
Phenolics and essential oil of peppermint were obtained by pressurized hot water extraction (PHWE). The best extraction conditions were found to be 130 °C for temperature, 10 min for extraction time, and 3 cycles for extraction number. There were no statistically significant differences between 130 and 160 °C in terms of essential oil content. Total phenolic contents (TPC) of the extracts were higher at 160 °C than that of 130 °C. However, further HPLC analysis of the extracts revealed that hydrolysis and/or decomposition of phenolics were observed in the extracts obtained at 160 °C. The main phenolic of peppermint was determined as eriocitrin by HPLC–DAD, while menthol was the dominant component in essential oil fraction of peppermint by GC-FID. The present study demonstrated that PHWE was a suitable technique for simultaneous extraction of phenolics and essential oil from peppermint. The technique might be used as an analytical extraction tool for determination of phenolics and essential oil. Moreover, the extracts of PHWE could directly be evaluated for the enrichment of liquid food formulations or be transformed into solid form by suitable techniques such as spray drying for easy storage and subsequent enrichment of food products. © 2018, Association of Food Scientists & Technologists (India)., National Council for Scientific Research, Acknowledgements This project has been financially supported by the Scientific and Research Council of Turkey (TUBITAK) under the Project Number of 113O471.
- Published
- 2018
79. Étude ostéodensitométrique des cols fémoraux chez l'hémiplégique
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Le Corre-Daniel, E, Moysan, C, Lambert, F, Le Cam, M, Weber, M, Dorval, MP, Le Bigot, P, Morin, JF, and Morin, PP
- Published
- 1996
- Full Text
- View/download PDF
80. Rééducation et fracture épistémologique
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Dorval, MP, Le Corre-Daniel, E, Moysan, C, Lambert, F, Le Cam, M, Weber, M, and Le Bigot, P
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- 1996
- Full Text
- View/download PDF
81. Fabrication and characterization of achillea Iycaonica- loaded poly(Lactic Acid) nanofibers
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ÇAM, MUHAMMET EMİN, CESUR, SÜMEYYE, TAŞKIN, TURGUT, GÜNDÜZ, OĞUZHAN, and Çam M. E., Cesur S., Taşkın T., Kabasakal L., Gündüz O.
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Health Sciences ,Engineering and Technology ,Klinik Tıp (MED) ,Mühendislik, Bilişim ve Teknoloji (ENG) ,Mühendislik ve Teknoloji ,Sağlık Bilimleri ,Engineering, Computing & Technology (ENG) ,Clinical Medicine (MED) - Published
- 2018
82. Çocukları dikkat eksikliği hiperaktivite bozukluğu tanısı alan ebeveynlerin iletişim becerilerinin, çocukların yaşam kalitesi ile ilişkisi
- Author
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Topcu, Ege Miray, Çam, Mahire Olcay, Psikiyatri Hemşireliği Anabilim Dalı, Çam M. Olcay, and Sağlık Bilimleri Enstitüsü
- Subjects
Dikkat Eksikliği Hiperaktivite Bozukluğu ,Quality of Life ,Nursing ,İletişim Becerileri ,Attention Deficit-Hyperactivity Disorder ,Hemşirelik ,Communication Skills ,Yaşam Kalitesi - Abstract
Çocukları Dikkat Eksikliği Hiperaktivite Bozukluğu tanısı alan ebeveynlerin, iletişim becerilerinin çocukların yaşam kalitesi arasındaki ilişki incelemek amacıyla yürütülen araştırma tanımlayıcı desendedir. Araştırma Mart – Mayıs 2017 tarihleri arasında Ege Üniversitesi Tıp Fakültesi Çocuk Hastanesi Psikiyatri Polikliniği ve Dokuz Eylül Üniversitesi Çocuk Ruh Sağlığı Polikliniğine gelen, araştırma kriterlerini karşılayan gönüllü çocuklar ve ebeveynleri ile yürütülmüştür. Araştırmada örneklem seçimine gidilmemiştir. Araştırmaya iki kurumdan 101 çocuk ve 101 ebeveyn gönüllü olarak katılmıştır. Araştırma verileri, çocukların ve ebeveynin tanıtıcı bilgilerini içeren birey tanıtım formu, Çocuklara Dikkat Eksikliği/Hiperaktivite Bozukluğu Yaşam Kalitesi Ölçeği (DE /HB – YK), ebeveynlere İletişim Becerileri Değerlendirme Ölçeği (İBDÖ) ve Çocuk Ana-Baba İlişki Ölçeğinin (ÇAİÖ) uygulanması ile elde edilmiştir. Ölçek puanlarının normal dağılıma uygunluğunu değerlendirilmesi için Shapiro-Wilk test istatistikleri ve ölçeklere uygun olarak parametrik olmayan yöntemler kullanılmıştır. Bulguların yorumlanmasında frekans tabloları ve tanımlayıcı istatistikler kullanılmıştır. Parametrik olmayan yöntemlere uygun şekilde bağımsız iki ve üstü grupların ölçek puanları ile karşılaştırılmasında Mann-Whitney U Testi, ve Kruskal-Wallis H Test istatistikleri kullanılmıştır. Ölçeklerin birbirleriyle ilişkisinin derecesi, yönü ve anlamlılığı Spearman Korelasyon Testi kullanılarak yapılmıştır. Araştırma sonuçlarına göre; çocukların yaş ortalamaları 10.43±1.29' dur. Çocukların %20.8'i kız, %79.2'si erkekti. Çocukların %25.7'sinde DEHB' eşlik eden bir hastalık bulunmaktadır ve %89.1'i de ilaç tedavisi almaktadır. Örneklemde yer alan ebeveynlerin yaş ortalaması 38.65 ± 5.86'dır. Ebeveynlerin %28.7'si DEHB hakkında bir kaynaktan eğitim almışlardır. Soruyu yanıtlayan çocukların değişim istekleri; okul başarılarına (%20), kendilerine (%16.47), aileleri (%14.11) ve arkadaşları (%5.88) ile ilişkilerine, somut nesnelere (%14.11), dünyaya (%5.88) yöneliktir. Çocukların %21.97'sinin hiçbir şey istemediğini belirtmiştir. Çocukların %21.97'sinin hiçbir şey istemediğini belirtmiştir. Çocukların yaşam kalitesi puan ortalaması ev yaşam alanında 62.22±13.31, okul yaşam alanında 61.17±13.29'dur. Ailedeki toplam çocuk sayısının artması, kreşe gitmiş olma, anaokuluna gitmiş olma, anne ve baba ile birlikte yaşamaması yaşam kalitesini (ev ya da okul yaşam alanlarında) olumsuz etkilemektedir. Çocukların sözel ifadeleri bu bulguları destekler niteliktedir. Ailede başka bir DEHB tanısı almış kişinin olması, yaşam kalitesinin olumlu etkilemektedir. Ebeveynlerin iletişim becerileri ortalamaları yüksek bulunmuştur (106.0±10.51). Ebeveynlerin ÇAİÖ toplam puan ortalamaları 59.31±14.26'dır. Çocukların yaşam kalitesi puan ortalamaları ile ebeveynlerin iletişim becerileri puan ortalamaları ve ana baba ilişki ölçeği puan ortalamaları arasında istatistiksel olarak anlamı bir ilişki yoktur. Araştırma örnekleminde DEHB tanılı çocukların yaşam kaliteleri ile ebeveynlerinin iletişim becerileri arasında bir ilişki saptanmamıştır., The study, which was conducted in order to examine the relationship between communication skills of the parents, whose child was diagnosed with attention deficit-hyperactivity disorder, and children's quality of life, is of descriptive pattern. The study was conducted with voluntary children, who admitted to Ege University Faculty of Medicine Children's Hospital Psychiatry Outpatient Clinic and to Dokuz Eylul University Child Psychiatry Outpatient Clinic between the dates March-May 2017 and met the inclusion criteria, and their parents. Sampling was not performed in the study. 101 children and 101 parents from the two institutions were participated voluntarily in the study. Study data were obtained by applying an individual identification form containing identification information of children and parents, Attention Deficit/Hyperactivity Disorder Quality-of- Life Scale (ADHDQoL) for children, The Communication Skills Scale (CSS) and Child-Parent Relationship Scale (CPRS) for parents. For evaluation of consistency of scale scores to normal distribution; Shapiro-Wilk test statistics and nonparametric methods, consistently with the scales, were used. For interpretation of the results; frequency tables and descriptive statistics were used. Consistently with the nonparametric methods, for comparison of scale scores of two and more independent groups; Mann-Whitney U Test and Kruskal-Wallis H Test statistics were used. Degree, direction and significance of the interrelationship of the scales were performed by using Spearman Correlation Test. According to the results of the research; mean age of the children is 10.43±1.29. Of the children; 20.8% were female and 79.2% were male. Of the children; 25.7% had a comorbid disease and 89.1% were on a drug therapy. Mean age of the parents included in the sample is 38.65 ± 5.86. 28.7% of the parents had been trained for ADHD by some sources. Children answering the question about the change requests is devoted to school success (%20), themselves (%16.47), Family (%14.11) and friends (%5.88) relationships, concrete object (%14.11), world (%5.88). 21.97% of the children stated that they did not want anything.Children's average ADHDQoL is 62.22±13.31 field of domestic life and 61.17±13.29 in field of school life. Increased total number of children in a family, having ever been in nursery, having ever been in kindergarten and not living with parents influence the quality of life (school or home life negatively (p0.05). As a result of research, the quality of life for children with ADHD with parents ' the relationship between communication skills has not been established. A relationship between the quality of life of children with ADHD and their parents' communication skills has not been established.
- Published
- 2017
83. Kanser hastalarında James Destekleyici Bakım Gereksinimlerini Belirleme Ölçeği'nin geçerlik ve güvenirlik çalışması
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Demirkol, Hacer, Çam, M. Olcay, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
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Psychiatry ,Reproducibility of results ,Quality of life ,Distres ,Distress ,Scales ,Cancer patients ,Patient satisfaction ,Nursing ,Kanser ,Reliability ,Güvenirlik ,Psikiyatri ,Geçerlik ,Validity ,Neoplasms ,Hemşirelik ,Cancer - Abstract
Araştırma, kanser tanısı almış bireylerin yaşadığı distresi ölçmek amacıyla Wells-Di Gregorio ve arkadaşları (2013) tarafından geliştirilen James Destekleyici Bakım Gereksinimlerini Belirleme Ölçeği'nin (James Supportive Care Screening) Türk toplumuna uyarlanarak, geçerlik ve güvenirliğini yapmak amacıyla gerçekleştirilmiştir. Araştırma, Ege Üniversitesi Tıp Fakültesi Hastanesi'ne bağlı Tülay Aktaş Onkoloji Hastanesi'nde yürütülmüştür. Araştırmanın evrenini, Tülay Aktaş Onkoloji Hastane'sine, ayakta kemoterapi tedavisi almak için başvuran bireyler oluşturmuştur. Araştırmanın örneklemini ise, araştırmaya dahil olma kriterlerini taşıyan ve araştırmaya katılmaya gönüllü olan 280 kanser tanısı almış birey oluşturmuştur. Veri toplama aracı olarak, Tanıtıcı Bilgi Formu, James Destekleyici Bakım Gereksinimlerini Belirleme Ölçeği (JDBGBÖ) ve ölçüt geçerliliği için EORTC QLQ-C30 Yaşam Kalitesi Ölçeği kullanılmıştır. JDBGBÖ'nin geçerlik çalışmasında ilk olarak; dil geçerliği sağlamak için, ölçeğin Türkçe'ye çevirisi ve geri çevirisi yapılmıştır. Dil geçerliği sağlandıktan sonra, içerik geçerliği için ölçek, uzman görüşüne sunulmuştur. Uzman görüşleri, Davis tekniği kullanılarak değerlendirilmiştir. Uzman görüşlerine göre, tüm maddelerin Kapsam Geçerlik İndeksi (KGİ) istenilen değer olan 0.80'in üzerinde bulunmuştur (KGİ>0.80). Ölçeğin ön uygulamasından sonra, veriler yüz yüze görüşme tekniği kullanılarak toplanmıştır. Bireylerin verdiği cevaplar, araştırmacının kendisi tarafından ölçeğe işaretlenmiştir. Ölçeğin kapsam geçerliği için, Temel Bileşenler Analizi ve Doğrulayıcı Faktör Analizi (DFA) yöntemi kullanılmıştır. Temel Bileşenler Analizine göre, ölçek orijinal yapısına uygun olarak altı faktör altında sıkıştırılmıştır. DFA uyum indeksleri değerleri kapsam geçerliği için uygun değerler arasında bulunmuştur (x2/df=2.073, RMSEA=0.62, CFI=0.91, NFI=0.90, NNFI=0.91, SRMR=0.07, GFI=0.90). Ölçeğin ölçüt geçerliliği için, ölçeğin Duygusal Sorunlar alt boyutu ile eşdeğer ölçeğin Duygusal Fonksiyon skoru arasında negatif yönde, ölçeğin Bilişsel Alanda Yaşanan Sorunlar alt boyutu ile eş değer ölçeğin Kavrama Fonksiyon skoru arasında negatif yönde anlamlı bir ilişki bulunmuştur. Ayrıca ölçeğin Fiziksel Belirtiler alt boyutu ile eş değer ölçeğin Semptom Ölçeği arasında pozitif yönde anlamlı bir ilişki bulunmuştur. Bu bulgulara göre, James Destekleyici Bakım Gereksinimlerini Belirleme Ölçeği Türk toplumu için geçerli bir ölçme aracıdır. JDBGBÖ'nin güvenirlik çalışması için ilk olarak, madde-toplam puan korelasyonları incelenmiştir. Madde 28'in madde-toplam puan korelasyon değeri en az istenilen değer olan 0.20 altında ve korelasyon için hesaplanan p değeri istatistiki açıdan anlamsız bulunmuştur (r=0.068, p=0.253). Madde 28, ölçekten çıkarıldığında, ölçeğin Cronbach alfa'sında önemli derecede değişiklik oluşmadığı ve orjinal ölçeğin kuramsal yapısını bozmamak adına madde çıkarma işlemine gidilmemiştir. Ölçeğin Cronbach alfa değeri 0.918 olarak, alt boyut Cronbach alfa değerleri ise; 0.549 ile 0.875 arasında bulunmuştur. JDBGBÖ'nin zaman karşı değişmezliğini belirlemek için, ölçek birinci uygulaman iki hafta sonra 30 kişiye tekrar uygulanmış ve iki ölçüm arasındaki ilişki değerlendirilmiştir. İlk ve son ölçümler incelendiğinde; alt boyut toplam puan ve ölçek toplam puan korelasyonları arasında pozitif yönde ileri düzeyde anlamlı bir ilişki bulunmuştur (p, The study was conducted in order to determine the validity and reliability of James Supportive Care Screening developed by Wells-Di Gregorio and his friends (2013) by applying it to Turkish society to measure the distress experienced by patients who were diagnosed as cancer. The study was conducted in Tülay Aktaş Hospital of Oncology contained within Ege University, Faculty of Medicine. The population of the study was chemotherapy outpatients applied to Tülay Aktaş Hospital of Oncology. 280 patients with cancer diagnoses who volunteered to join and met the participation criteria of the study made up the research sample. Descriptive Information Form, James Supportive Care Screening and EORTC QLQ-C30 Quality of Life Scale which was used for criterion validity, were used as data collecting tools. First translation to Turkish and re-translation of the screening was done for language validity in the validity study of James Supportive Care Screening. After providing the language validity, the screening scale was submitted for expertise for content validity. Expertise was evaluated by Davis technique. According to experts Content Validity Index (CVI) of all items was above the required value 0.80 (CVI>0.80). After the pre-application of the scale, data was collected via face to face interviews. The answers provided by the subjects were marked by the researcher on the scale. Principal Component Analysis and Confirmatory Factor Analysis (CFA) were used for construct validity of the scale. Through the Principal Component Analysis, the scale was compress as six-factors, complying with the original scale. CFA fit indices values (x2/df=2.073, RMSEA=0.62, CFI=0.91, NFI=0.90, NNFI=0.91, SRMR=0.07, GFI=0.90) were determined as sufficient for providing construct validity. For criterion validity of the scale; it was found negative relation between Emotional Concerns sub-dimension of the scale and Emotional Function rating of equivalent scale, negative relation between Cognitive Concerns subscale of the scale and Comprehensive Function rating of the equivalent scale. In addition it was found a positive relation between Physical Symptom subscale of the scale and Symptom Scale of the equivalent scale. Based on these findings; James Supportive Care Screening is a valid scaling tool for Turkish society. For reliability studies of James Supportive Care Screening, first correlations between items and total scores were evaluated. Correlation point of item 28 (r=0.068) was found to be below the minimum required value of 0.20 and calculated p value for correlation of item 28 found statistically insignificant (r=0.068, p=0.253). Dismiss of the article was not preferred to avoid disruption of original theoretical structure of the scale and because there was no significant difference in Cronbach alpha of the scale in case of dismissal. Cronbach alpha value of the scale was found to be 0.918 while subscale Cronbach alpha values were between 0.549 and 0.875. In order to determine the stability of James Supportive Care Screening, scale was applied to 30 patients two weeks later than the first application and article total score correlations were compared. When the first and last results were examined, a significant relation was seen between subscale total scores and scale total scores (p
- Published
- 2016
84. Ebeveyninde bipolar bozukluk olan gençlerin benlik tasarımlarının incelenmesi
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Küçük, Gülhan, Çam, M. Olcay, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
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Psychiatry ,Ego ,Parents ,Bipolar disorder ,Gençler ,Scales ,Nursing ,The Parents With Bipolar Disorder ,Ebeveyninde Bipolar Bozukluk ,Benlik Tasarımı ,Youngs ,Psikiyatri ,Self design ,Self-concept ,Hemşirelik ,Young People - Abstract
Bu çalışmanın amacı, ebeveyninde bipolar bozukluk olan gençlerin benlik tasarımlarını incelemektir. Araştırma ebeveyninde bipolar bozukluk olan 131 genç ile yürütülmüştür. Araştırmaya katılan gençlere Tanıtıcı Bilgi Formu ve Benlik Tasarımı Ölçeği uygulanmıştır. Ebeveyninde bipolar bozukluk olan gençlerin sosyo-demografik özelliklerinden yaş, cinsiyet, eğitim durumu, medeni durum ve aile yapısı ile benlik tasarımı puan ortalamaları arasında anlamlı bir fark bulunmazken gelir düzeyi ile benlik tasarımı puan ortalmaları arasında anlamlı farklılık saptanmıştır. Gelir düzeyi yüksek olan gençlerin, gelir düzeyi düşük olan gençlere oranla benlik tasarımı ölçeğinden aldıkları puanların daha yüksek olduğu bulunmuştur. Ebeveyninde bipolar bozukluk olan gençlerin hangi ebeveyninin hasta olduğu, hasta olan ebeveynin eğitim durumu, yaşı, hastalık tanı yılı ve hasta ebeveynle birlikte yaşama yılı benlik tasarımı puan ortalamalarını etkilememiştir. Ancak yetişirken anne babası dışında büyükannesinden ve büyükbabasından destek alan gençlerin benlik tasarımı ölçeğinden aldıkları puanların daha yüksek olduğu bulunmuştur. Ebeveyninde hastalık olmayan gençlerin oluşturduğu örneklemlerle kıyaslandığında ebeveyninde bipolar bozukluk olan gençlerin benlik tasarım puan ortalamasının daha düşük olduğu görülmektedir. Bu gençlerin benlik tasarımlarının olumlu yönde arttırılabilmesi için uzman desteğine ihtiyaçları vardır. Ruh sağlığı ekibinin bir üyesi olarak uzman psikiyatri hemşirelerinin bu bağlamdaki müdahaleleri olumlu katkı sağlayacaktır., The purpose of this study is to examine the self-concept of young people having parents with bipolar disorder. The study was conducted with 131 young people having parents with bipolar disorder. A Descriptive Information Form and the Self-concept Scale were applied to the young people participating in the study. While no significant difference was found between age, gender, educational status and family structure among socio-demographic characteristics of young people having parents with bipolar disorder and their self-concept mean scores, there was a significant difference between income level and self-concept mean scores. It was determined that the young people with higher income level obtained higher scores from self-concept scale compared to the young people with lower income level. Which parent suffered from this order, educational status and age of ill parent, diagnosis year of the disorder and number of years young people lived with ill parent did not affect self-concept mean scores of the young people having parents with bipolar disorder. However, the young people receiving support from their grandmother and grandfather apart from their parents during their upbringing period obtained higher scores from self-concept scale. When compared to samples including young people having parents with no disorder, it was observed that the young people having parents with bipolar disorder had a lower self-concept mean score. These young people need an expert support in order to enhance their self-concept positively. Related interventions of specialized psychiatric nurses as a member of mental health team would make positive contribution.
- Published
- 2016
85. Comparison of the attachment styles of normal adolescence and adolescence diagnosed with substance use disorder
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Aydoğdu, Hilal, Çam, M. Olcay, Ege Üniversitesi, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
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Psychiatry ,Social support ,Parents attitude ,Madde kullanım bozukluğu, bağlanma stilleri, ana-baba tutumu, sosyal destek ,Attachment styles ,Psikiyatri Hemşireliği A.B.D ,Nursing ,Hemşirelik ,Psikiyatri ,Substance use disorder, attachment styles, parenting style, social support - Abstract
Bu çalışma, madde kullanım bozukluğu olan ve olmayan ergenlerin bağlanma stilleri arasındaki ilişkinin araştırılması, bağlanma stilinin, ebeveyn tutumlarının ve sosyal desteğin madde kullanımına etkisinin değerlendirilmesi amacı ile yapılmış, tanımlayıcı tipte bir araştırmadır.Araştırma 272 madde kullanım bozukluğu olan ve 272 madde kullanım bozukluğu olmayan, aynı sosyo-demografik özelliğe sahip 14-18 yaşları arasındaki basit tesadüfi yöntemle seçilmiş ergenlerle yapılmıştır. Araştırma, mayıs-temmuz 2012 tarihleri arasında İzmir ili metropolünde yer alan madde bağımlılığı merkezi polikliniğine başvuran basit tesadüfi yöntemle seçilmiş 14-18 yaşları arasındaki madde kullanım bozukluğu olan ergenler ve aynı sosyo-demografik özelliklere sahip resmi liselerin 9,10,11,12'inci sınıflarında eğitim gören 14-18 yaşları arasındaki basit tesadüfi yöntemle seçilmiş ergenler ile yürütülmüştür.Araştırmacı tarafından İzmir Milli Eğitim Müdürlüğü ve Ege Üniversitesi Çocuk ve Ergen Alkol Madde Bağımlılığı Araştırma ve Uygulama Merkezi'nden gerekli izinler alındıktan sonra ebeveynleri tarafından araştırmaya katılımı onanan ve araştırmayı sürdürecek düzeyde ruhsal iyilik düzeyine sahip olan ergenler ile yüz yüze görüşülerek, sosyo-demografik özelliklerin yer aldığı Tanıtıcı Bilgi Formu, İlişki Ölçekleri Anketi, Anne- Baba Tutum Ölçeği ve Çok Boyutlu Algılanan Sosyal Destek Algısı Ölçeği uygulanmıştır. Elde edilen verilerin sayı, yüzde dağılımı, medyan, standart sapma ve minimum-maximum değerleri hesaplanmıştır. Bağımlı ve bağımsız değişkenler arasındaki ilişkiyi belirlemek üzere Independent t testi, Mann-Whitney U testi, Kendall Tau-b ve Spearman's Rho korelasyon testleri, Pearson Chi-square testi ve Lojistik regresyon analizi kullanılmıştır.Araştırma sonucunda madde kullanım bozukluğu olan ergenlerin madde kullanım bozukluğu olmayan ergenlere göre, daha düşük düzeyde güvenli ve saplantılı bağlandığı, daha yüksek düzeyde korkulu ve kayıtsız bağlandığı; toplam sosyal destek algısının ve aile desteği algısının madde kullanım bozukluğu olmayan ergenlere göre, daha düşük olduğu; ailelerinin daha az kabul-ilgi, kontrol-denetleme gösterdiği ve psikolojik özerklik sağladığı bulunmuştur.Güvenli bağlanma ile ebeveynin kabul ve ilgisi, aile desteği ve toplam sosyal destek arasında; saplantılı bağlanma ile aile desteği ve toplam sosyal destek arasında; kayıtsız bağlanma ile ailenin kabul ve ilgisi, aile desteği ve toplam sosyal destek arasında pozitif yönde ilişki saptanmıştır.Ayrıca İlişki Ölçekleri korkulu bağlanma alt boyutu ile psikolojik özerklik, arkadaş desteği, uzman kişi desteği arasında; saplantılı bağlanma alt boyutu ile psikolojik özerklik ve uzman kişi desteği arasında, kayıtsız bağlanma alt boyutu ile psikolojik özerklik arasında olumsuz yönde korelasyon saptanmıştır.Sonuç olarak bulgular, madde kullanım bozukluğu olan ve olmayan ergenlerin bağlanma stilleri, anne baba tutumları ve sosyal destek algıları arasında farklılık olduğunu göstermiştir.Elde edilen sonuçlar doğrultusunda madde kullanım bozukluğu olan ergenlere ve ailelerine psikiyatri hemşiresi tarafından yapılandırılmış, destekleyici, terapötik bir ruhsal destek programı verilmesi halinde ergenin çevresi ile güvenli ilişkiler kurmasına yardımcı olunacaktır. This research is a descriptive field study conducted in order to investigate of the differences between normal adolescence and adolescence diagnosed with substance use disorder and was to evaluate the effect of attachment style, parent attitude and social support on substance use.The research was carried on total 544 adolescence consist of 272 adolescence diagnosed with substance use disorder and 272 normal adolescence who have similar socio-demographic characteristics with adolescence diagnosed with substance use disorder, between 14-18 years old, chosen with the simple randomly method. In the research, population has been composed of adolescence between 14-18 years old who resort to polyclinic of drug addiction center and 9th,10th,11th,12th grade high school students -selected by randomly-who have attended governmental school in İzmir Metropolitan between may- july 2012.Identifier information form, Parenting Style Inventory, Multidimensionel Scale of Perceived Social Support and Adolescent Relationship Scales Questionnaire was applied to adolescence who have mental well-being to maintaining participating and getting informed consent from adolescence?s parents. After givin permission by the researcher from National Education Ministry and Ege University Drug Addiction Center for Child and Adolescence in Izmir. Data were collected through a face to face from adolescences .According to the data obtained in the research, number and percentage distribuitons, median, standart deviation, min max values were calculated. Independet t Test, Mann-Whitney U test, Kendall Tau-b and Spearman's Rho correlation tests, Pearson Chi-square test and Logistics Regression analysis were used to determine the relation between dependent variables and independent variables.At the end of the research, the adolescence diagnosed with substance use disorder had less secure and preoccupied attachment than normal adolescence and more fearful and dismissed attachment. Also the adolescence diagnosed with substance use disorder had less family and total social support than normal adolescence and their family broght them less parental acceptance and involvement, less control attitude, and psychological autonomy.There was positive corelation between secure attachment style with parental acceptance and involvement, family support, total social support and preoccupied attachment style with family support, total social support. Significant positive correlations were found between dismissed attachment style and parental acceptance and involvement, family support, total social support..Also there was a significant negative correlation between psychological autonomy, support from friend and fearful attachment style subscales of Adolescent Relationship Scales Questionnaire and there was a negative correlation between preoccupied attachment with psychological autonomy and dismissed attachment with psychological autonomy.In conclusion, there were differences between the adolescence diagnosed with substance use disorder and normal adolescence about attachment style, parent attitude and social support.According to the results of this study, in order to given the therapeutic, structured mental support program by psychiatric nursing to adolescences and their family who have substance use disorder. 136
- Published
- 2013
86. Establishing the correlation of intensive care unit nurses state of mind and death attitude profile
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Önsöz, Saime Banu, Çam, Mahire Olcay, Psikiyatri Hemşireliği Anabilim Dalı, Çam, M. Olcay, and Ege Üniversitesi, Sağlık Bilimleri Enstitüsü
- Subjects
Psychiatry ,Intensive care units ,Yoğun bakım hemşireleri, ruhsal durum, ölüme karşı tutum ,Nurses ,Nursing ,Nursing research ,Psikiyatri ,Intensive care unit nurses, state of mind, death attitude profile ,Death ,Intensive care ,Psychological status ,Attitudes ,Psikiyatri Hemşireliği A.B.D ,Hemşirelik - Abstract
Önsöz, S.B. Yoğun Bakım Hemşirelerinin Ruhsal Durumları İle Ölüme Karşı Tutumları Arasındaki İlişkinin Saptanması, Ege Üniversitesi Sağlık Bilimleri Enstitüsü Psikiyatri Hemşireliği Yüksek Lisans Tezi, İzmir, 2013. Araştırma, yoğun bakım hemşirelerinin ruhsal durumları ile ölüme karşı tutumları arasındaki ilişkiyi incelemek amacıyla yapılmış tanımlayıcı ve ilişkisel tipte bir araştırmadır. Araştırma üç farklı hastanenin reanimasyon yoğun bakımlarında çalışan ve araştırmaya katılmayı kabul eden 91 hemşireyle yürütülmüştür. Veriler Tanıtıcı Bilgi Formu, Kısa Semptom Envanteri ve Ölüme Karşı Tutum Ölçeği kullanılarak toplanmıştır. Verilerin değerlendirilmesinde Kruskal-Wallis, Mann Whitney U testi ve Pearson Korelasyon Testi kullanılmıştır. Araştırma da, kronik/akut hastalık varlığı, geçirilmiş ruhsal hastalık varlığı, şu anda ruhsal hastalığının olması, ölüm konusunda aldığı eğitimi yeterli bulup/bulmama durumu, çalıştığı birim seçimini kendinin yapıp/yapmaması, aileye ölüm haberini verme, ölüm olayları karşısındaki duyguları değişkenleri hemşirelerin ruhsal durumlarını etkilerken; medeni durum ve ölüm olayı karşısındaki duyguları değişkenleri hemşirelerin ölüme tutumlarını etkilemiştir (p < 0.05). Ayrıca yoğun bakım hemşirelerinin kısa semptom envanteri ile ölüme karşı tutum ölçeğinin korelasyonu karşılaştırıldığında; kısa semptom envanterinin hostilite, fobik anksiyete ve psikotisizm alt boyutları ile ölüme karşı tutum ölçeğinin kaçış kabullenme alt boyutu arasında pozitif yönde zayıf bir ilişki saptanmıştır. Bu bulgular doğrultusunda yoğun bakımlarda çalışan hemşirelerin ruhsal durumunun periyodik olarak takip edilmesi, ölüme ilişkin farkındalığı sağlayacak eğitim programlarının düzenlenmesi önerilmiştir.Anahtar Kelimeler: yoğun bakım hemşireleri, ruhsal durum, ölüme karşı tutum. Önsöz, S.B. Establishing the correlation of intensive care unit nurses state of mind and death attitude profile, Aegean University Graduate School of Health Sciences, Psychiatric Nursing Postgraduate Thesis, İzmir, 2013. Study, which was made to analyse the relation of intensive care unit nurses state of mind and death attitude, is a descriptive and a relational form. Study was carried out with ninety-one nurses working at reanimation intensive care unit of three different hospitals and accepting to be part in the study. Parameters were gathered by using Introductory Information Form, Brief Syptom Inventory and Death Attitude Profile Revised (DAP-R). Kruskal-Wallis, Mann-Whitney U test and Pearsons Correlation Test were used in evaluating the parameters..Whilst absence of chronic / acute disease, previous mental illness, to have mental illness at present, adequateness of the education on the death cases, making the unit selection on her own or not, death knell to the family and their emotive variables about death cases affects the nurses mental state, emotive variables about marital status and the death case affects the attitudes of the nurses on the death. (p < 0.05). Besides when the correlation of brief symptom inventory and death attitude profile compared; a positively poor relation was found between brief symptom inventorys hostility, phobic anxiety and lower dimensions of psychoticism and in lower dimensions of acceptance escape of death attitude profile. In the direction of this findings it is advised to follow intensive care units nurses state of mind periodically and to organize education programmes providing death awareness.Key Words: intensive care unit nurses, state of mind, death attitude profile. 179
- Published
- 2013
87. Bipolar bozukluk tanısı alan hastalarda içselleştirilmiş damgalamayı azaltmada psikoeğitimin etkinliği
- Author
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Çuhadar, Döndü, Çam, M. Olcay, Psikiyatri Hemşireliği Anabilim Dalı, and Ege Üniversitesi, Sağlık Bilimleri Enstitüsü
- Subjects
Psychiatry ,Psychological counseling ,Psycho-educational program ,Bipolar disorder ,Stigma, Internalized Stigma, Bipolar Disorder, Psychoeducation ,Psychology ,Psikiyatri Hemşireliği A.B.D ,Nursing ,Hemşirelik ,Damgalama, İçselleştirilmiş Damgalama, Bipolar Bozukluk, Psikoeğitim ,Stigmatization ,Psikiyatri - Abstract
Bu araştırma, içselleştirilmiş damgalamayı azaltmaya yönelik olarak hazırlanan bir psikoeğitim programının etkinliğini belirlemek amacıyla, deney-kontrol deseninde deneysel bir araştırma olarak yapılmıştır.Araştırma, 1 Haziran 2010- 2 Mayıs 2011 tarihleri arasında bipolar bozukluk tanısı alan hastalarla yürütülmüştür. Araştırmanın örneklemini 47 hasta (24 deney, 23 kontrol) oluşturmuştur. Araştırmanın etiği için kurumlardan ve hastalardan yazılı izinler alınmıştır.Psikoeğitim sonrası deney grubunda, Yabancılaşma kalıp yargıların onaylanması algılanan ayrımcılık sosyal geri çekilme gibi RHİDÖ alt ölçekleri puan ortalamalarının istatistiksel olarak anlamlı düzeyde azaldığı, damgalamaya karşı direnç alt ölçeği puan ortalamasının anlamlı farklılık göstermediği belirlenmiştir. Sontest RHİDÖ toplam puan ortalaması deney grubunda kontrol grubuna göre istatistiksel olarak anlamlı düzeyde azalmıştır.Bu sonuçlar, içselleştirilmiş damgalamaya yönelik olarak hazırlanan bir psikoeğitim programının bipolar bozukluk hastalarının içselleştirilmiş damgalama düzeylerine olumlu yönde etkisinin olabileceğini ortaya koymuştur. This research was done in experimental-control design as experimental study to determine the effectiveness of psychoeducation that prepared towards to reduce internalized stigma.Research was carried out between 1 June 2010-2 May 2011 with patient who have bipolar disorder diagnosis. 47 patients (24 experimental, 23 control) formed the sample of research. For ethic of the research, written approvals taken from ınstitutes and patients.After psychoeducation in experimental group, these were determined that, alienation, stereotypes endorsement, perceived discrimination, social withdrawn sub scale mean score get decreased as statistically significant, the mean score of stigma resistance sub scale didnt show significant differences Postest ISSMI total mean score has decreased as statistically significant in experimental group according to control group.This result put forward that, psychoeducation which designed towards to internalized stigma may have positive effect on the internalized stigma level of bipolar disorder patients. 205
- Published
- 2011
88. Evaluation the impact of psychoeducation on psychosocial adaptation in myocardial ınfarction patients
- Author
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Nehir, Sevgi, Çam, M. Olcay, Ege Üniversitesi, Sağlık Bilimleri Enstitüsü, Çam, Mahire Olcay, and Psikiyatri Hemşireliği Anabilim Dalı
- Subjects
Myocardial infarction ,Adjustment ,Nurses ,Psychosocial features ,Psikiyatri Hemşireliği A.B.D ,Nursing ,Patient education ,Hemşirelik - Abstract
Bu araştırma Miyokard İnfartüsü geçirmiş bireylere verilen psikoeğitimin tedavideki etkinliğini ve psikososyal uyuma etkisini incelemek amacıyla, deney-kontrol deseninde yarı deneysel bir araştırma olarak yapılmıştır. Araştırma, Ege Üniversitesi Kardiyoloji Anabilim Dalı ve Manisa Özel Sekiz Eylül Hastanesi Kardiyoloji Polikliniğine başvuran Miyokard İnfarktüsü geçirmiş hastalarla Haziran 2010-Mart 2011 tarihleri arasında yürütülmüştür. Örneklem seçim kriterlerini karşılayan ve psikoeğitim görüşmelerini katılmaya gönüllü 30 deney grubu ve 30 kontrol grubu seçilen 60 hasta oluşturmuştur. Psikoeğitim girişimleri araştırmacı tarafından ilgili literatür doğrultusunda geliştirilmiştir. Bireysel olarak deney grubu ön test ve son testleri tamamlanan 30 hastanın her biriyle 6 kez olmak üzere eğitim ve görüşme yapılarak uygulanmıştır. Araştırmanın verileri gerekli izinler alındıktan sonra, hastalara ön test ve son test uygulanarak iki aşamada toplanmıştır. Verilerin toplanmasında Tanıtıcı Bilgi Formu ve Hastalığa Psikososyal Uyum- Öz Bildirim Ölçeği (PAIS-SR) kullanılmıştır. Veriler sayı, yüzde dağılımı ve paired sampled t test kullanılarak değerlendirilmiştir. Psikoeğitim uygulamaları sonrasında deney grubu hastaların PAIS-SR (toplam) ön test puan ortalaması 40.67±12.28, son test puan ortalaması 32.71±11.01 olarak bulunmuştur. Hastaların ön ön test ve son test PAIS-SR (toplam) puan ortalamaları arasındaki fark incelendiğinde, bu farkın anlamlı düzeyde olduğu saptanmıştır (Z=-4.382, p
- Published
- 2011
89. Adli psikiyatri hastalarına yönelik hemşire tutum ölçeği geliştirme
- Author
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Baysan Arabacı, Leyla, Çam, M. Olcay, and Ege Üniversitesi, Sağlık Bilimleri Enstitüsü
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Psikiyatri Hemşireliği A.B.D - Abstract
Arastırma, hemsirelerin, adli psikiyatri hastasına yönelik tutumlarını belirlemek amacıyla bir ölçek gelistirmek ve gelistirilen ölçegin geçerlik ve güvenirligini saptamak amacıyla, metodolojik tipte planlanmıs ve uygulanmıstır. Arastırmanın evrenini, Türkiye’de yer alan Saglık Bakanlıgı’na baglı Ruh Saglıgı ve Hastalıkları Hastalıkları Hastaneleri’nde çalısan tüm hemsireler (N=910) olusturmaktadır. Evrenin tümü arastırmaya dahil edilip, örneklem seçimine gidilmemistir. Arastırma katılmayı kabul eden 650 hemsire ile yürütülmüstür. Veri analizinde, ölçegin %85’i doldurulmayan 30 anket ve ölçekteki en az bir maddenin yanıtsız bırakıldıgı 84 anket geçerlik ve güvenirlik degerlendirmesi dısında bırakılarak, verilerin degerlendirmesi toplam 536 anket üzerinden yapılmıstır. Arastırmada, Tanıtıcı Bilgi Formu, Ruhsal Hastalıga Yönelik nançlar Ölçegi (RH Ö) ve Adli Psikiyatri Hastalarına Yönelik Hemsire Tutum Ölçegi (APHHTÖ) kullanılmıstır. APHHTÖ niteliksel (kuramsal) ve niceliksel olmak üzere iki süreçte gelistirilmistir. Kuramsal süreçte “odak grup görüsmesi” ve “kompozisyon formları” ve literatürde psikiyatri alanında gelistirilmis çesitli tutum ölçekleri kullanılmıstır. Elde edilen verilerin niteliksel analizi sonrasında 115 maddeden olusan APHHTÖ aday formu gelistirilmistir. Niceliksel süreçte, kapsam geçerliligi için Lawshe teknigi kullanılmıs ve yapılan uzman degerlendirmesi sonrasında 35 maddelik ilk form olusturulmustur. Bu formun tüm evrene uygulanmasından sonra yapılan geçerlik ve güvenirlik degerlendirmeleri sonucunda 10 maddesi çıkarılarak, APHHTÖ’nin 25 maddeden olusmasına karar verilmistir. APHHTÖ’in geçerlik ve güvenirlik çalısmasında kapsam geçerlik indeksi (KG ) .69, RH Ö ile olan uyum geçerliligi .44, iç tutarlılıgı belirleyen Cronbach Alpha katsayısı .86 ve küme içi korelasyon katsayısı .86, ön-test ile son-test arasındaki tutarlılıgı belirleyen kararlılık katsayısı .69 bulunmustur. Ön-test puan ortalamaları ile son-test puan ortalamaları arasındaki fark istatistiksel olarak da anlamlı bulunmamıstır (t=0.247, p>0.05). Yapılan faktör analizi dogrultusunda APHHTÖ’nin, “sosyal mesafe (21, 22, 23, 24. maddeler)”, “bakım vermede isteklilik (13, 16, 17, 18, 19, 26, 27. maddeler)”, “güven (14, 15, 25, 29, 30, 32, 33, 34. maddeler)” ve “tehlikeli görme (1, 2, 3, 5, 6, 7. maddeler)” olmak üzere dört alt boyuttan olustugu saptanmıstır. Ölçekteki pozitif maddelerin her biri “Kesinlikle Katılmıyorum (1)’dan, “Tamamen Katılıyorum (5)”a dogru, negatif maddeler ise tam tersi olacak biçimde 5’li likert seklinde düzenlenmistir. Ölçekten elde edilecek en yüksek puan “125”, en düsük puan “25”dir. Yüksek puan adli psikiyatri hastasına yönelik olumlu tutumu göstermektedir. Bu veriler dogrultusunda, Adli Psikiyatri Hastalarına Yönelik Hemsire Tutum Ölçegi”nin geçerli ve güvenilir bir ölçek oldugu belirlenmistir.
- Published
- 2009
90. Ege Üniversitesi sağlık bilimleri bölümlerindeki öğrencilerin kendini açma özelliklerinin incelenmesi
- Author
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Çobanoğlu Elçi, Sevinç, Çam, M. Olcay, and Diğer
- Subjects
Self disclosure ,Nursing ,Hemşirelik ,University students - Abstract
ÖZET Bu araştırma Ege Üniversitesi Sağlık Bilimlerine bağlı okullarda öğrenim gören öğrencilerin kendini açma özelliklerini incelemek amacıyla tanımlayıcı olarak yapılmıştır. 1997-1998 öğretim yılında Ege Üniversitesi Sağlık Bilimlerine bağlı Tıp Fakültesi, Eczacılık Fakültesi, Diş Hekimliği Fakültesi, Hemşirelik Yüksek Okulu son sınıflarında okuyan 145 öğrenci araştırma kapsamına alınmıştır. Araştırma verileri öğrencilerin tanıtımına ilişkin bilgileri kapsayan bilgi formunun ve Jourard Kendini Açma (Self Disclosure) Envanterinin uygulanması ile toplanmıştır. Elde edilen verilerin değerlendirilmesinde sayı ve yüzde dağılımları, aritmetik ortalama (x), standart sapma (ss), student-t testi ve varyans analizleri uygulanmıştır. Araştırmada elde edilen sonuçlar şunlardır: *Öğrencilerin kendini açmak için aynı cins arkadaşlarını daha fazla tercih ettikleri,.öğrencilerin düşünce ve görüşleri ile zevk ve ilgilerine yönelik konularda diğer konulara göre daha açık davrandıkları, *Kız öğrencilerin erkek öğrencilere göre kendilerini daha fazla açtıkları, *Çekirdek aile yapısına sahip öğrencilerin diğerlerine göre kendilerini daha fazla açtıkları, *Kardeşi olmayan öğrencilerin diğerlerine göre kendilerini daha fazla açtıkları, *Babaları ile ilişkileri iyi olan öğrencilerin kendilerini daha fazla açtıkları, insanlarla iletişim kurmada zorluk çeken öğrencilerin kendilerini daha az açtıkları, *Kendini yeterince açamadığını düşünen öğrencilerin daha düşük puan aldıkları sonuç olarak kendilerini yeterince açamadıklarının farkında oldukları, *Kız öğrencilerin erkek öğrencilere göre anneye, aynı cins arkadaşa, öğretmene kendilerini daha fazla açtıkları, 54*Kız öğrencilerin erkek öğrencilere göre düşünce ve görüşleriyle, okulla, aileyle, cinsellikle ilgili konularda kendilerini daha fazla açtıkları, *Hemşirelik Yüksek Okulu öğrencilerinin diğer okullardaki öğrencilere göre aynı cins arkadaşlarına ve öğretmenlerine daha fazla açıldıkları, *Hemşirelik Yüksek Okulu öğrencilerinin diğer okullardaki öğrencilere göre düşünce ve görüşleriyle, okulla, aileyle ilgili konularda kendilerini daha fazla açtıkları saptanmıştır. Araştırmada bu sonuçlar doğrultusunda çeşitli önerilerde bulunulmuştur. 55 SUMMARY The research, a descrptive one, has been done to examine Self Disclosure characteristics of E.U. Healt depertment students.The research covers, one year period from 1997 to 1998.145 last class students in depertments ; medicine, pharmaceutics, dentistry, nursing undergraduate school of E.U are included in this research.. Health departments continuing education 145 of last class student. Data has been obtained from application form that including knowledge about students and Self Disclosure Questionaire of data are evaluated according to number and percentage distribution, aritmetic mean (x), standart deviation (SD). Also, student T test and analyses of variance are used for isthatisticel. The result of the reseach are as follows; the students prefer same genus of friends more to disclose their selves, the students are more discloseable according to their stylish and relation which belongs to their ideas and in visibilities than other the subjects.the girl students disclose theirselves more than boy students, the. students who have member of small familie disclose theirselves more than others, the students haven't got sibling disclose theirselves more than others.the students whose contacts are good with their fathers disclose theirselves more than others, the students who are hard in communication with people discole theirselves less than the others, the students who think that it's enougha to disclose theirselves are getting low points, as a result of this they know that it's not enough to disclose theirselves. The girl students disclose theirselves to mother, to the same genus of friend, to a teachermore than the boy students, the girl students disclose theirselves about the their ideas and the invisibilities, the school, the family more than the boy students, the students of.undergraduate Nursing scool are more discloseable to their same genus of friend and to their teachers than the other students, the students of undergraduate Nursing scool are more discloseable about their ideas and invisibilities, the scool, the family than other students. Some suggestions have been made in accordance with the results of the research. 56 63
- Published
- 1998
91. Performance and health status in preweaning semi-indoor holstein calves wearing calf jackets during winter months.
- Author
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Çam M, Arslan E, Kaya ZK, and İnal Ş
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- Animals, Cattle physiology, Cattle growth & development, Female, Male, Health Status, Animal Husbandry methods, Weight Gain, Cattle Diseases prevention & control, Housing, Animal, Seasons, Weaning
- Abstract
The purpose of this study was to investigate whether jacket wearing by semi-indoor Holstein calves affected performance, body measurements and health status in the preweaning period throughout the winter months. A total of one hundred calves were allocated into two treatment groups (control and jacket) in terms of their weights and sex. The calves throughout the study period were raised at individual calf hutches in a semi-open barn. All calves and the consumed concentrate intakes were weighed every 28 days to determine body weight (BW), average daily gain (ADG), total and daily feed consumption (TFC, DFC). Incidence rate (IR) ratios were calculated from the records of daily health assessments. Calves in treatment group were jacketed from first to 45 days of age. The weaning process started gradually at 56 days of age and the calves were weaned on day 63. No significant effects of wearing jackets in terms of body measurements and performance. The respiratory diseases IR was 1.15 times higher in calves without jackets, which means that calf health was positively affected by wearing jackets. The improved health status of the treatment group showed that wearing jackets may protect calves from adverse effects of cold stress. There is a need for more comprehensive studies about the effect of calf jackets in early periods of preweaning, especially in calves in outdoor hutches., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
- Full Text
- View/download PDF
92. Upgrading the Bioactive Potential of Hazelnut Oil Cake by Aspergillus oryzae under Solid-State Fermentation.
- Author
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Ozdemir MB, Kılıçarslan E, Demir H, Koca E, Salum P, Berktaş S, Çam M, Erbay Z, and Aydemir LY
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- Phenols chemistry, Aspergillus oryzae metabolism, Fermentation, Corylus chemistry, Antioxidants pharmacology, Antioxidants chemistry, Plant Oils chemistry, Plant Oils pharmacology
- Abstract
Hazelnut oil cake (HOC) has the potential to be bioactive component source. Therefore, HOC was processed with a solid-state fermentation (SSF) by Aspergillus oryzae with two steps optimization: Plackett-Burman and Box-Behnken design. The variables were the initial moisture content (X
1 : 30-50%), incubation temperature (X2 : 26-37 °C), and time (X3 : 3-5 days), and the response was total peptide content (TPC). The fermented HOC (FHOC) was darker with higher protein, oil, and ash but lower carbohydrate content than HOC. The FHOC had 6.1% more essential amino acid and benzaldehyde comprised 48.8% of determined volatile compounds. Fermentation provided 14 times higher TPC (462.37 mg tryptone/g) and higher phenolic content as 3.5, 48, and 7 times in aqueous, methanolic, and 80% aqueous methanolic extract in FHOC, respectively. FHOC showed higher antioxidant as ABTS+ (75.61 µmol Trolox/g), DPPH (14.09 µmol Trolox/g), and OH (265 mg ascorbic acid/g) radical scavenging, and α-glucosidase inhibition, whereas HOC had more angiotensin converting enzyme inhibition. HOC showed better water absorption while FHOC had better oil absorption activity. Both cakes had similar foaming and emulsifying activity; however, FHOC produced more stable foams and emulsions. SSF at lab-scale yielded more bioactive component with better functionality in FHOC.- Published
- 2024
- Full Text
- View/download PDF
93. The mediator role of mindfulness in the relationship between the listening skills and anger management skills of emergency health care professionals.
- Author
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Dil S and Çam M
- Subjects
- Humans, Female, Male, Adult, Turkey, Cross-Sectional Studies, Surveys and Questionnaires, Emergency Service, Hospital, Middle Aged, Mindfulness methods, Health Personnel psychology, Anger
- Abstract
Background: Effective communication plays a crucial role in establishing strong relationships and providing essential support in clinical situations. This study was conducted to investigate the mediator role of mindfulness in the relationship between the listening skills and anger management skills of healthcare professionals working in the emergency department (ED)., Method: This was a cross-sectional study, which was conducted with 230 emergency department healthcare professionals (EHCPs) working in adult EDs in Turkey. Sociodemographic Characteristics Data Collection Form, Mindful Attention Awareness Scale (MAAS), Listening Skills Assessment Scale (LSAS), and Anger Management Scale (AMS) were used for data collection. Descriptive statistics included frequency and percentage; t test and ANOVA test were used for statistical analyses, as was "Process Macro 3.5 Model 4", which was used to study the effect of mediator variables., Results: The participants had a mean MAAS score of 57.71 ± 12.38, a mean LSAS score of 45.36 ± 6.23, and a mean AMS score of 17.93 ± 3.39. There were significant positive correlations between LSAS and MAAS (r = 0.197, p < 0.001), between AMS and MAAS (r = 0.233p < 0.001), and between AMS and LSAS r = 0.24p < 0.001). In addition, the process model analysis results supported that MAAS had a partial mediator role in the correlation between LSAS and AMS, and that its indirect effects were predicted by LSAS and AMS. It was determined that 5.75 % of total change on AMS was predicted by LSAS (F = 13.918; p < 0.001)., Conclusion: The results of this study indicate that as the mindfulness level of EHCPs increases, their listening and anger management skills increased. Therefore, reinforcing mindfulness by integrating mindfulness interventions into in-service training and applying strategies that promote EHCPs' listening skills and anger management skills would make it possible to provide quality health care with employees who are more efficient in conflict management and enjoy a higher level of satisfaction., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
- Full Text
- View/download PDF
94. Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
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Koç S, Şen S, Terzi Y, Kızılay F, Demir S, Bekar Aksoy D, Kurtuluş F, Bilge N, Idilman E, Uzunköprü C, Güngör S, Çilingir V, Ethemoğlu Ö, Boz C, Gümüş H, Kılıç AK, Kısabay A, Bir LS, Turan ÖF, Soysal A, Köseoğlu M, Tekgöl Uzuner G, Bayındır H, Canbaz Kabay S, Çam M, Yayla V, Tan H, Özcan A, Taşkapıoğlu Ö, Korkmaz M, Tamam Y, İnanç Y, Efendi H, Kotan D, Yetkin MF, Bilgiç AB, Saçmacı H, Demirci S, Çelik Y, Poyraz T, and Terzi M
- Subjects
- Humans, Male, Female, Adult, Retrospective Studies, Middle Aged, Optic Neuritis blood, Optic Neuritis immunology, Optic Neuritis diagnostic imaging, Neuromyelitis Optica blood, Neuromyelitis Optica immunology, Neuromyelitis Optica diagnostic imaging, Autoantibodies blood, Autoantibodies analysis, Aged, Adolescent, Immunoglobulin G blood, Multiple Sclerosis blood, Multiple Sclerosis immunology, Myelin-Oligodendrocyte Glycoprotein immunology
- Abstract
Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited., Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG., Study Design: Multicenter, retrospective, observational study., Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study., Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients., Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
- Published
- 2024
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95. The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis.
- Author
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Taşkıran E, Terzi M, Helvacı EM, Eser MZ, Avcı B, Ömer Faruk T, Yetkin MF, Çilingir V, Bir LS, Kabay SC, Bilge N, Poyraz T, Demir CF, Dündar DK, Ocak Ö, Çam M, Mavioğlu H, Altun Y, and Karaibrahimoğlu A
- Subjects
- Humans, Oligoclonal Bands cerebrospinal fluid, Immunoglobulin G therapeutic use, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis drug therapy, Multiple Sclerosis, Chronic Progressive cerebrospinal fluid, Multiple Sclerosis, Relapsing-Remitting cerebrospinal fluid
- Abstract
Background/aim: Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index., Methods: Our study included 401 MS patients who had relapsing-remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), secondary progressive multiple sclerosis (SPMS), clinic isolated syndrome (CIS), radiologic isolated syndrome (RIS), Neuromyelitis optica spectrum disorder (NMOSD) and Acute disseminated encephalomyelitis (ADEM) with OCB number groups of 2-4, 4-8, 8-12, and 12 and above., Results: No significant correlation was observed between IgG index, pre-and post-treatment EDSS (Expanded Disability Status Scale Scores) and disease-modifying therapies (DMT). Drug response was better in the patient group with band number between 2 and 8 and post-treatment EDSS scores were lower (1.62±0.44)., Conclusion: The study results suggested that band number may be as valuable as the IgG index and a predictive biomarker for disease activity., Competing Interests: Declaration of competing interest None., (Copyright © 2023. Published by Elsevier B.V.)
- Published
- 2024
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96. Determination of the effect of the dam age, birth type, and sex on growth curve traits of hair goat kids.
- Author
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Güler S, Çam M, and Atik A
- Subjects
- Animals, Male, Female, Phenotype, Body Weight, Goats, Dietary Supplements
- Abstract
This study was conducted to investigate the best-fit growth curve and dam age, sex, and birth type effect on growth curve traits of hair goat kids. Monthly 3858 test day body weight (BW) records of 643 hair goat kids from birth to 150 days of age were used to determine the best-fit growth curve and estimate growth curve parameters with Gompertz and Von Bertalanffy models. The BW records were assigned to three groups: dam age (3, 4, 5, 6, 7 years), sex (female, male), and birth type (single, twin). The Gompertz model gave more consistent results than the Von Bertalanffy model according to the goodness of fit criteria. Dam age had no significant effect on any of the growth curve traits. Sex of kids showed a significant effect on maturity index (parameter K) (P < 0.001), estimated mature body weight (parameter A), and weight at point of inflection (IPW) (P < 0.01). Also, birth type had a significant effect on initial/birth weight (parameter B) and parameter K (P < 0.001). Age at point of inflection (IPT) was not affected by any of the factors. Twin kids had a higher maturity index than singles while females higher than males. In conclusion, the Gompertz model was the most suitable model for hair goat kids for selection strategies. For proper selection, the effect of sex and birth type on growth curve traits should be considered by hair goat breeders., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2023
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97. Erratum: Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment.
- Author
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Terzi M, Helvacı EM, Şen S, Boz C, Çilingir V, Akçalı A, Beckmann Y, Uzunköprü C, Türkoğlu R, Yüceyar N, Efendi H, Destan Bünül S, Seferoğlu M, Kotan D, Güler S, Balcı BP, Öztürk B, Mungan S, İçen NK, Ömerhoca S, Yurtoğulları Ş, Sevim S, Türkoğlu ŞA, Çam M, Yetkin MF, Yoldaş TK, Sıvacı AÖ, Gökçe ŞF, Gürsoy E, Ünal A, Bilge N, Ağan K, Toprak MK, Koçer B, Sözer G, and Terzi Y
- Abstract
[This corrects the article on p. 23 in vol. 60, PMID: 36911568.]., (Copyright: © 2023 Turkish Neuropsychiatric Society.)
- Published
- 2023
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- View/download PDF
98. Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment.
- Author
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Terzi M, Helvacı EM, Şen S, Boz C, Çilingir V, Akçalı A, Beckmann Y, Uzunköprü C, Türkoğlu R, Yüceyar N, Efendi H, Bünül SD, Seferoğlu M, Kotan D, Güler S, Balcı BP, Öztürk B, Mungan S, İçen NK, Ömerhoca S, Yurtoğulları Ş, Sevim S, Türkoğlu ŞA, Çam M, Yetkin MF, Yoldaş TK, Sıvacı AÖ, Gökçe ŞF, Gürsoy E, Ünal A, Bilge N, Ağan K, Toprak MK, Koçer B, Sezer G, and Terzi Y
- Abstract
Introduction: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey., Method: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively. Data regarding efficacy and safety of the patients were transferred to the data system both before the treatment and on the 6th, 12
th and 24th month following the treatment. The data were analyzed using the IBM SPSS 20.00. P value of <0.05 was considered to be statistically significant., Results: A total of 508 multiple sclerosis patients, 331 of whom were women, were included in the study. Upon comparing the Expanded Disability Status values before and after the treatment, a significant decrease was observed, especially at month 6 and thereafter. Since bradycardia occurred in 11 of the patients (2.3%), the first dose had to be longer than 6 hours. During the observation of the first dose, no issues that could prevent the use of the drug occured. Side effects were seen in 49 (10.3%) patients during the course of fingolimod treatment. Respectively, the most frequent side effects were bradycardia, hypotension, headache, dizziness and tachycardia., Conclusion: The observed results regarding efficacy and safety were similar to clinical trial data in the literature and real life data in terms of the first equivalent with fingolimod active ingredient., Competing Interests: Conflict of Interest: The authors declared that there is no conflict of interest., (Copyright: © 2023 Turkish Neuropsychiatric Society.)- Published
- 2023
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99. Changes in serum total protein and immunoglobulin G concentrations and Brix percentages in neonatal Arabian foals from birth up to 21 days of age.
- Author
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Akköse M, Karabulut E, İnal Ş, Dik GÇ, Özbeyaz C, Kaya U, Çam M, and Topal B
- Subjects
- Female, Pregnancy, Animals, Horses, Animals, Newborn, Sensitivity and Specificity, Immunodiffusion veterinary, Immunodiffusion methods, Colostrum, Immunoglobulin G, Refractometry methods, Refractometry veterinary
- Abstract
The aim of this study was to evaluate changes in the serum immunoglobulin G (IgG) and serum total protein (STP) concentrations and serum Brix percentages of neonatal Arabian foals during first 3 weeks of life. Blood samples were collected from 12 apparently healthy foals by jugular venipuncture at birth and at 12-hours, 24-hours, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15 and 21 days of age. Serum IgG and STP concentrations and Brix percentages were measured by the radial immunodiffusion assay, and digital STP and Brix refractometers, respectively. Based on the serum IgG concentrations measured at 24 h, two foals were diagnosed with failure of transfer of passive immunity (FTPI). While IgG concentrations were determined using the data of foals with adequate transfer of passive immunity, other calculations were made using the data of all foals. The mean IgG concentration of the foals increased from birth (<200 mg/dl) to 12 (2068.5 mg/dl) and 24 h (2184.7 mg/dl), and progressively decreased up to 21 days of age (1318.5 mg/dl). The serum IgG concentrations at 12 h were highly correlated with each of the IgG concentrations measured over the 21-day period. The serum IgG and STP concentrations and Brix percentages of the foals diagnosed with FTPI at 12 h did not reach the adequate strata over time. These results suggest that foals can be reliably tested for passive immunity status at 12 h after birth., Competing Interests: Conflict of Interest No conflict of interest., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2023
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100. Optimization of ultrasound-assisted aqueous two-phase system (ATPS) of phenolics from apple pulp and peel.
- Author
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İşçimen EM, Berktaş S, Çam M, and Hayta M
- Subjects
- Chlorogenic Acid, Acetone, Plant Extracts, Phenols analysis, Fruit chemistry, Rutin, Water, Antioxidants, Malus
- Abstract
In this study, extraction of phenolic compounds from apple peel and pulp was optimized using an ultrasound-assisted aqueous two-phase system (UA-ATPS) consisting of acetone-NaH
2 PO4 and acetone-(NH4 )2 SO4 with the help of Response Surface Methodology. The effectiveness of UA-ATPS was compared with certain extraction methods including traditional aqueous two-phase system (T-ATPS), ultrasound-assisted acetone extraction (UA-ACE) and traditional acetone extraction (T-ACE). The UA-ATPS gave better results than traditional methods in terms of phenolic and flavonoid contents and antioxidant activity values regardless of the fruit parts used. The status of extraction yield was observed with three major phenolics of apple including chlorogenic acid, rutin and phloridzin. Striking increases in chlorogenic acid and rutin contents in the peel were determined when acetone was replaced with ATPS in the same extraction system with equal extraction time (20 min). The present study has indicated that UA-ATPS is an effective method for phenolic extraction from apple peel and pulp.- Published
- 2023
- Full Text
- View/download PDF
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