701. [Analysis of CD8(+) and CD8(+)CD28(-) cell subsets in patients with hepatocellular carcinoma].
- Author
-
Qiu YR, Yang CL, Chen LB, and Wang Q
- Subjects
- Adult, CD28 Antigens immunology, Female, Humans, Male, CD28 Antigens analysis, CD8-Positive T-Lymphocytes immunology, Carcinoma, Hepatocellular immunology, Liver Neoplasms immunology, T-Lymphocyte Subsets immunology
- Abstract
Objective: To study the expression of the costimulatory molecule CD28 on peripheral blood CD8(+)T cells from patients with hepatocellular carcinoma (HCC)., Method: The expression of CD28 on CD8(+), CD8(+)CD28(-)- and CD8(+)CD28(+) cell subsets in the peripheral blood obtained from 20 HCC patients and 15 healthy controls were assayed by flow cytometry., Results: The elevated percentages of CD8(+) cells, decreased percentages of CD8(+)CD28(+) cells and increased percentages of CD8(+)CD28(-)- cells were observed in the peripheral blood of HCC patients as compared with those of the control group (P<0.01). Positive correlation between the percentage of CD8(+)CD28(-)- cells and that of CD8(+) cells were found., Conclusion: CD28 expression on CD8(+) T cells was aberrant in the peripheral blood of HCC patients, and the elevation of CD8(+)CD28(-)- cell number results in the increase of CD8(+) cell number.
- Published
- 2002