601. Phospholamban of cardiac sarcoplasmic reticulum consists of two functionally distinct proteolipids.
- Author
-
Chiesi M, Gasser J, and Carafoli E
- Subjects
- Animals, Calmodulin pharmacology, Cattle, Cyclic AMP pharmacology, Kinetics, Phosphorylation, Protein Kinases metabolism, Rats, Adenosine Triphosphatases isolation & purification, Calcium-Binding Proteins isolation & purification, Myocardium enzymology, Proteolipids isolation & purification, Sarcoplasmic Reticulum enzymology
- Abstract
Phosphorylation of phospholamban by either a cAMP-dependent or a calmodulin-dependent kinase stimulates the Ca2+ transporting activity of cardiac sarcoplasmic reticulum membranes. It has now been found that phospholamban consists of 2 distinct proteins; one is the specific substrate for the cAMP-dependent phosphorylation, and the other for the calmodulin-dependent kinase. In spite of functional diversity, the 2 polypeptides share a number of properties. Among them, the proteolipid character, Mr, resistance to trypsinization, and subunit composition.
- Published
- 1983
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