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Aim: To compare the efficacy of monotherapy with quadropril (spirapril) vs captopril in essential hypertension., Material and Methods: 20 female patients aged 55 +/- 2 years with moderate hypertension (WHO classification) were included in the study. 16 patients had congestive heart failure stage II NYHA and 4 patients stage III NYHA. ECG and echocardiography were performed in all the patients. Two patient groups of 10 patients were treated for 6 weeks. Group 1 received 6 mg quadropril once daily. Group 2 received 25 mg captopril 3 times daily. The therapy was considered to be efficient if diastolic pressure (BP) was reduced to 90 +/- 5 mm Hg and systolic BP to 140 +/- 10 mm Hg from baseline values in the range of 210/120-170/100 mm Hg., Results: The hypotensive effect of quadropril resulted in stabilisation of BP during the second week of therapy. A significant BP decrease was achieved at the end of 6 week therapy. Systolic BP fell from 178.8 +/- 3.2 to 145 +/- 5.6 mm Hd and diastolic BP from 109.7 +/- 1.2 to 92.4 +/- 1.7 mm Hg. Central and cardiac hemodynamic parameters improved. In one patient the condition improved from CHF stage III to stage II NYHA. No adverse effects were observed. A hypotensive effect of captopril reduced significantly systolic blood pressure from 182.1 +/- 2.7 to 150 +/- 4.6 mm Hg and diastolic BP from 110.4 +/- 1.1 to 100.1 +/- 1.9 mm Hg. Two patients developed adverse effects: cough and chest dyscomfort., Conclusion: Quadropril monotherapy showed to be more effective in diastolic BP decrease compared with captopril monotherapy and had advantages in one daily dose regimen, absence of the first dose effect and side effects.

The article analyses the treatment of hemorrhoids in our country and abroad, where outpatient treatment with latex rings is applied most frequently. The authors conducted 238 hemorrhoidectomies under conditions of outpatient clinics. They developed an operative method consisting in preventive compression of the base of the hemorrhoids with designs of alloy with "memory" of the shape. This method was used in 118 hemorrhoidectomies. No life-threatening complications occurred. Late-term recurrences were recorded in 1.6% of cases. It is claimed that hemorrhoidectomy can be performed in outpatient clinics if certain rules are observed. The is convenient for the patients and economically profitable for the State.