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Objective To explore the effect of self-made cooling Chinese medicine spray on relieving thirst in postoperative patients with esophageal cancer. Methods A total of 212 patients undergoing elective surgery for esophageal cancer were selected as the study subjects. According to the principle of comparability of basic characteristics between groups, they were divided into control group and observation group, with 106 patients in each group. In the control group, the cotton swabs moistened with water were used to moisturize the mouth and lips of patients. In the observation group, the 5 mL transparent spray bottle containing self-made cooling Chinese medicine solution was used for relieving thirst in the observation group. The degree of thirst, thirst-induced discomfort, oral mucosa moistness and the number of additional intervention were compared between the two groups 1h, 2h, 4h and 6h after tracheal intubation removal. Results At each time point, the degree of thirst, thirst-induced discomfort and oral mucosa moistness score in the two groups decreased gradually with time(P＜0. 01), and it was lower in the observation group than in the control group(P＜0. 01). There is an interaction between groups and time(P＜0. 01). The number of additional interventions per patient in the observation group was lower than that in the control group within 6h after extubation, and the difference was statistically significant(P＜0. 01). Conclusion Self-made cooling Chinese medicine spray can effectively relieve the thirst of postoperative patients with esophageal cancer, improve the comfort and save nursing time. (目的 探讨自制中药清凉喷雾剂缓解食管癌术后患者口渴症状的效果。方法 便利抽取2021年1月—2022年12月确诊并行择期手术治疗的食管癌患者212例为研究对象, 按照组间基本特征具有可比性的原则分为对照组和观察组, 各106例。对照组采用棉签蘸水湿润口唇, 观察组采用盛有自制中药清凉喷雾剂的5 mL透明喷雾瓶喷洒解渴。比较两组患者拔除气管插管后1 h、2 h、4 h、6 h的口渴程度、口渴不适感、口腔黏膜湿润程度及6 h内额外干预次数。结果 两组在各时间点的口渴程度、口渴不适感、口腔黏膜评分均随时间呈逐渐降低的趋势(P时间＜0. 01), 且观察组均低于对照组(P组间＜0. 01), 组别与时间存在交互作用(P交互＜0. 01)。拔管后6 h内观察组每例患者额外干预次数低于对照组, 差异有统计学意义(P＜0. 01)。结论 自制中药清凉喷雾剂可有效缓解食管癌术后患者的口渴程度, 提升患者舒适度, 节省护理时间。)

In order to study the relationship between grassland plant community, species richness, its distribution pattern and their influencing variables. Taking the Kuizu Mountain in Lhasa Basin as the study area, the plant community structure, species richness along the altitudinal gradient and their relationships with influential variables were studied. A total of 13 sample plots were set up at every 100 m altitude with five samples of 0.5 m × 0.5 m at each plot in the study area for vegetation survey. The plant community structure and distribution were analyzed by using TWINSPAN(two-way indicator species analysis)and PCA(principal component analysis). RDA(redundancy analysis)was played to analyze the correlations between plant community structure, distribution and environmental variables(altitude, slope). The regression analysis was used to analyze the correlations between species richness and abiotic(altitude, slope)and biotic(total coverage, separate coverage and above ground biomass)variables. PCA and TWINSPAN results showed that the vegetation in the study area was divided into three communities including seven plant associations. The results of RDA showed that altitude was the main variable influencing the plant community composition and its distribution pattern followed by slope in the study area. The results of regression analysis showed that the species richness had a single-peak relationship with altitude and separate coverage, and was positively correlated with total coverage, slope and above ground biomass. This study provides a scientific baseline for the conservation of plant species diversity and sustainable utilization of mountain plant resources in the study area. [ABSTRACT FROM AUTHOR]

[Objective] The revelation of physiological mechanisms affected by sucrose types and concentration in somatic embryogenesis is important,which is helpful for the procedural optimization in Agapanthus praecox. [Method ] The effects of different concentrations (2%, 3%, 4%) of three sugar types( sucrose, glucose maltose) on somatic embryo induction and maturation were studied,and physiological indexes containing endogenous hormones,saccharides, and oxidative stress were measured. [Result] The sucrose had a better effect on somatic embryogenesis, followed by glucose and maltose. 3% sucrose was suitable for young embryo induction, with the induction number of 117.33 per gramby using embryogenic callus. At the stage of mature embryo development, 2% sucrose had a good production, with 51.75 mature embryos developed. Carbon source played a significant role in regulating saccharide metabolism, hormone metabolism and oxidative stress in mature somatic embryo development. The metabolic balance between starch and sucrose might play a decisive role in mature embryo development. A relatively high concentration of IAA and GA was unfavorable to mature embryo development. Meanwhile, a high level of H2O2 and SOD was unfavorable to mature embryo development. [Conclusion] This study showed that 2 % sucrose was a better carbon source for mature embryo developmentin A. praecox,and the conversion between starch and sucrose, hormones including IAA and GA were the main factors restricting mature embryo development in A. praecox, which provided a reference for the technical optimization and SE related theoretical research. [ABSTRACT FROM AUTHOR]

For a kind of complex systems which the sufficient data cannot be obtained by testing and field operating, Monte Carlo (MC) measures for real-time reliability estimate are proposed. First, the failure time sequence of components is considered as the sample space, and more virtual samples are generated through the MC simulation measure based on it. Then a general framework for real-time reliability estimator is presented, and the relationship of prior information and variance of an MC estimator is studied. Under the information with a relation of inclusion, the variance of an estimator based on less prior information is less than that of an estimator based on more prior information. Second, the failure time sequence of all or part of the components which contribute to the failure of system is considered, and the real-time reliability models are developed respectively. A numerical example is provided to enlighten the idea. [ABSTRACT FROM AUTHOR]

Area, a field experiment was conducted in 2013-2015 for two consecutive years in National Agricultural Experimental Station for Agricultural Environment, and three mulching patterns were set up: plastic film mulching at autumn (film mulching begins after harvest in autumn, AM), plastic film mulching at spring (conventional growing season mulching, SM), and no film mulching (NM). Combined with 15N isotope tracer method, the characteristics of water and nitrogen utilization of spring corn mulched in autumn were analyzed. The precipitation during the growing period of spring maize was 310 and 249 mm in 2014 and 2015, respectively, which was lower than the historical average. During the experiments, maize was not irrigated. The aboveground dry matter of maize, biomass yield, grain yield, water consumption and water use efficiency were determined. The results showed that the AM treatment promoted maize growth. After the tasseling period, the aboveground dry matter of maize in the AM treatment was 8.7% and 4.5% higher than the treatments of SM and NM, respectively. The grain yields of AM treatment in 2014 and 2015 were 19% and 11% higher than the SM treatment and 14% and 75% higher than the NM treatment (P<0.05), but there was no significant difference on biomass yield between AM and SM (P>0.05) in the two consecutive years of relative drought. The AM treatment reduced the water consumption in the leisure period (P<0.05), the soil water storage in the sowing period increased by 35 mm on average compared with SM and NM treatments. The water consumptions of maize during tasseling and filling periods was significantly increased (P＜0.05). There were no significant difference in water use efficiency of grain yield and that of biomass yield of maize among the three treatments in 2014 (P>0.05). There was no significant difference in water use efficiency of grain yield and that of biomass yield of maize between AM and SM in 2015(P>0.05), but both were significantly higher than NM(P<0.05). The AM and SM treatments averagely increased the water use efficiency of grain yield and that of biomass yield of maize by 60% and 65% compared to NM in 2015. The AM treatment reduced the nitrogen fertilizer loss, and also reduced the nitrogen fertilizer residue in the soil compared with SM treatment, which improved the use efficiency of nitrogen fertilizer significantly in the current season and the following year (P<0.05). The cumulative nitrogen fertilizer use efficiency reached 50.5% in the two years, while those of SM and NM treatments were only 42.7% and 33.5% in the two years, respectively. However, the residual fertilizer nitrogen of AM treatment in the 0-100 cm soil layer was significantly higher than that of NM treatment (P<0.05). Therefore, the comprehensive analysis showed that autumn film mulching was an effective technical measure for improving the water and nitrogen fertilizer use efficiency and yield of spring maize in the semi-arid west of Liaoning province under the relatively dry years. Optimizing the application of nitrogen fertilizer can further enhance the value of this technology in regional agricultural development. [ABSTRACT FROM AUTHOR]

Based on the Held investigation and mineragraphy , the mineralization stages were identfied for Chedu gold depostt in Mianluening block of Shaanxi. According to the metamorphic degree of rock (ore) and crosscutting relationship of minerals , the mineralization can be divided into three stages：① sedimentary-metamorphic stage , high-grade layered gold ore body formed is accompanied by the sedimentation-metamorphism of magnetite quartzite；② hydrothermal mineralization stage , is divided into two substages , including smoky gray quartz sulfide vein and sulphide-bearing carbonate vein , in which native golds are observed；③ supergenesis stage , gold is further enriched to form large native gold grains accompanied by oxidization of magnetite. The native gold in Chedu gold deposit occurs as magnetite fractures, along the grain boundaries of magnetite and quartz, and within magnetite, pyrite, and calcite. The main occurrence states of gold inChedu gold deposit are intergranular gold, inclusion gold and tissure gold. Based on high- grade gold and distribution scale in quartz sulfide veins and sedimentary bands of magnetite quartzite, the genesis of Chedu gold deposit s classified as magnetite quartzite type, which s of great significance for the next geological prospecting in the area. [ABSTRACT FROM AUTHOR]

Objective * To establish a T&pid method to evaluate the activity of agonistic antibody using 0X40 (tumor necrosis factor receptor superfamily member 4)/FcyR (Fey recq)tor)-humanized mice. Methods*Bone marrow cells from OX40-humanizedmice and FcyR-humanized mice were collected and mixed with equal ratio. Then the mixed bone marrow cells were administrated into irradiated wild-1ype mice through the tail veins* The reconstruction efficiency of the immune system was confirmed by detecting the expression of hOX40 and hFcyR in the immime cells of chimera mice. After the chimera mice were generated successfully, they were used to evaluate the immimostimulatory activity of anti-hOX40 antibodies to CD4+ or CD8+ T cells. The results of flow cytometry were statistically analyzed. The unpaired f-test was used to compare the means between the two groups，and oneway ANOVA was used to compare the means between multiple groups. ResuUs • Flow cytometry analysis showed that wild-type recipient mice were efficiently reconstituted with hFcyR expressing cells and hOX40 expressing cells to generate OX40/FcyR-humanized bone marrow chimera mice. In these mice, B cells and myeloid cells expressed hFcyRs (PO.05), and T cells expressed hOX40 upon in vitro stimulation (P<0.05). When these mice were used to evaluate the immimostimulatory activity of anti-hOX40 antibody, significant expressions of EFN-y and hOX40 were observed (P<0.05). Conclusion - OX40ZFcyR-humamz©d bone marrow chimera mice are generated based on hFc?yR expressing cells and hOX40 eressing cells, suggesting a rapid method to build a mouse model with both hFcyR and hOX40 expressiotL These mice are suitable for evaluatii堪 the imraunostimulatoiy activity of agonistic human anti-hOX40 antibodies. [ABSTRACT FROM AUTHOR]

Objective To assess therapeutic efficacy and safety of balloon assisted enteroscopy (BAE) for treatment of Peutz-Jeghers polyps (PJP) with intussusceptions, and to explore the critical factors that affect the choice of treatment for PJP with intussusception. Methods The clinical data of patients identified as PJP intussusception were collected at the Air Force Medical Center from January 2013 to June 2019. Forty-eight patients were finally enrolled according to the inclusion and exclusion criteria. The ration of male to female was 28∶20, and the mean age was (20.6±9.2) years old. The success rate, the incidence of complications and other clinical data,such as age, gender, history of surgeries, clinical symptoms, diameter of lead polyps, the number of intussusceptions, and the longest length of single intussusception were analyzed. Case control study was performed to compare the different indexes between patients in pure enteroscopic treatment group and surgical treatment group. Results The overall effective rate of BAE treatment of PJP with intussusception was 83.3% (35/42), and the postoperative complication rate was 2.4% (1/42). Thirty-five patients that were treated successfully by BAE were classified as the BAE group, and 13 patients treated with surgery were classified as surgery group. There were no statistically significant differences in gender, history of surgeries, positive rate of PJS family history, average diameter of lead polyps and number of intraoperative polyps between the two groups. The average age was smaller in BAE group than that in surgery group. The proportion of patients with no or mild clinical symptoms was higher in the BAE group than that in surgery group. The number of intussusception was less in the BAE group than that in surgery group, and the longest length of single intussusception was shorter than that in surgery group (P＜0.05). Conclusion BAE is safe and effective in the management of PJP with intussusception, which can be used as the first-line treatment for PJP with intussusception coinciding incomplete intestinal obstruction. [ABSTRACT FROM AUTHOR]

BACKGROUND: Stem cells from the apical papilla (SCAP) play important roles in the formation and development of dental roots. However, the immune-modulating capacity of SCAP has not been fully elucidated. OBJECTIVE: To test the therapeutic effects of transplantation of SCAP on dextran sulfate sodium-induced experimental colitis. METHODS: Twenty-four C57/BL6 mice were equally divided into four groups (normal control, positive control, SCAP treatment group, and FasL-knockdown SCAP group), and latter three groups of mice were induced to acute experimental colitis by 3% dextran sulfate sodium in drinking water. At day 3 after modeling, model mice were treated with PBS, human SCAP (2x106 cells), and FasL-knockdown SCAP via intraperitoneal injection, respectively. Inflammation was evaluated by measuring body mass and length of the colon, detecting levels of interleukin 1β, interleukin 6 and tumor necrosis factor α, as well as histological analyses at day 10 after modeling. Levels of Tregs in mesenteric lymph nodes in mice were detected using flow cytometric analysis. RESULTS AND CONCLUSION: SCAP transplantation could ameliorate the inflammation in dextran sulfate sodium-induced colitis mice, and body mass loss and symptoms were significantly improved. Pathological score and the levels of three inflammatory cytokines in the colon tissue decreased significantly. Flow cytometric analysis revealed an increased level of Tregs in mesenteric lymph nodes. Knocking down of FasL gene in SCAP abrogated the therapeutic effects of SCAP in ameliorating dextran sulphate sodium-induced colitis. Therefore, Fas-FasL pathway played an important role in the underlying mechanism of the immune-modulating capacity of SCAP. [ABSTRACT FROM AUTHOR]

[Objective]In order to optimize parity structure and mating time of pig population, the effects of parity and mating season on gestation length and litter performance were studied. [Method]A reproductive record of total 3278 parities in 2016-2017 years for American Large White Sows from breeding pig faom of Yunnan Huijia Breeding Company Limited was analyzed. [Result] The breeding season had significant effect on the total litter size, the number of live litters（P <0.05）. The total number born and number born alive of sows in spring were significantly higher than those in summer and autumn（P <0.05）. It had significant difference under different parities for the total number born number born alive number of stillbirths, gestation period and so on（P<0.05）. The litter performance of the 3rd-5th parities and the 7th parity was better than that of other parities. [Conclusion] The best reproductive performance of the American White Sows is the 3rd, 4th, 5th and 7th parities, and the mating performance of sows in spring is better than that in other seasons. [ABSTRACT FROM AUTHOR]

Objective To study the effects of low-dosage and standard-dosage CEE (Conjugated Equine Estrogens) plus natural progesterone or dydrogesterone on bone mineral density ( BMD) in perimenopausal syndrome patients. Methods 83 perimenopausal syndrome patients treated from January 2015 to June 2017 in our hospital were selected and randomly assigned to group I (n = 28)，group II (n = 27)，group III (n = 26) and group IV (n = 26). Patients took low-dosage ECC plus natural progesterone, low-dosage ECC plus dydrogesterone, standard-dosage ECC plus natural progesterone or standard-dosage ECC plus dydrogesterone, respectively. Comparisons between groups were made for hormone levels before and after treatment, Kupperman scores at menopausal period and adverse reactions. Results Before treatment, the clinical symptom scores and the related index including FSH (follicle-stimulating hormone), E2 (estradiol) and LH (luteinizing hormone) for each group were not significantly different (尸 > 0. 05). After one to three treatment courses, the Greene scores for each group were reduced, with statistically significant differences among groups (P<0. 05) ； the values of FSH, E2 and LH for each group were improved, but the FSH values in group I and group III were higher than the other groups and the values of E2 and LH were lower (P<0. 05). Before treatment, the BMD of LI~4 and femoral neck for each group was not significantly different (P> 0.05). After treatment, the BMD of LI~4 and femoral neck for each group was improved, especially in group I and group III (P<0. 05). Conclusion The standard-dosage CEE plus natural progesterone could remarkably relieve the clinical symptoms. However, the low-dosage CEE plus natural progesterone could not only relieve the clinical symptoms, but also improve the hormone levels and produce no negative effect on BMD. The proper dosage of CEE should be taken according to the patient’s actual conditions. [ABSTRACT FROM AUTHOR]

Gentiopicroside （GPS），the main active ingredient of Gentianace which is a kind of pretty popular Chinese traditional herb drug， will be widely distributed in human's tissue and organs （including the lungs， liver， heart， brain， etc） as being used by oral or intravenous administration. GPS always has efficacy of anti-inflammatory， anti-fibrosis， anti-oxidative stress， anti-apoptosis， or inhibition of tumor cell proliferation. Recently， many researches revealed it was wealthy exploring the usage of GPS on alcoholic/non- alcoholic liver diseases， drug/toxicant induced liver diseases，and fulminant hepatitis. Besides liver relating diseases， GPS also has huge potentials to treatment ofgastrointestinal，pancreatic，heart，pulmonary， or bone and joint diseases，as well as neuropsychiatric disorders，cancer，or anti-pathogenic microorganism. [ABSTRACT FROM AUTHOR]

Learning individual preferences of users for items from user‑item rating matrix is critical for rating recommendation. Many recommendation methods，such as the Latent Factor model，can not make full use of the interaction information from rating matrix to learning individual preferences，and achieve unsatisfying results. Inspired by wide and deep learning model of deep learning in APP recommendation，deep hybrid model is proposed and named DeepHM for rating recommendation. Compared with the wide and deep model， deep wide model and DNN model are used to reconstruct wide model and deep model，which can get DeepHM and make DeepHM become shared input to its deep wide and deep parts. Therefore，DeepHM uses interaction information of user and item from rating matrix more efficiently to obtain individual preferences information. Furthermore，DeepHM treats the rating recommendation as a multi ‑ classification problem aiming to improve the accuracy of recommendation. Through comprehensive experiments on public Movielens datasets，it demonstrates that the efficiency of DeepHM based on rating recommendation is better than that of the existing models. [ABSTRACT FROM AUTHOR]

To explore the effect of different doses of ulinastatin combined with atomolan on serum oxidative stress, inflammatory reaction and prognosis in patients with septic shock. 100 patients with septic shock who were treated in our hospital from May 2014 to June 2018 were selected. According to the random number table method, the patients were divided into the ulinastatin group (ulinastatin 200,000 U/d), the atomolam group (atomolam 1.8 g/d), the low-dose combination group (ulinastatin 200,000 U/d and atomolam 1.8 g/d), the high-dose combination group (ulinastatin 400,000 U/d and atomolam 1.8 g/d), with 25 cases in each group. The changes of oxidative stress indexes [malondialdehyde (MDA), advanced oxidation protein products (AOPP), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px)] and inflammation indexes[interleukin-6(IL-6), tumor necrosis factor-琢(TNF-琢), procalcitonin (PCT) and c-reactive protein (CRP)] of patients between the three groups before and after treatment were compared. Meanwhile, the differences in prognosis between the three groups were compared. The ICU hospitalization time, mechanical ventilation time, acute physiological and chronic health (APACHE II) scores and sequential organ failure (SOFA) scores, and the level of serum MDA, AOPP, IL-6, TNF-琢, PCT and CRP after treatment of patients in the high-dose combined group were all lower than those in the ulinastatin group, the atomolam group, and the low-dose combined group, while the low-dose combined group were lower than those in the ulinastatin group and the atomolam group (P＜ 0.05). The level of serum SOD, T-AOC, GSH-Px after treatment of patients in the high-dose combined group were all higher than those in the ulinastatin group, the atomolam group, and the low-dose combined group, while the low-dose combined group were higher than those in the ulinastatin group and the atomolam group (P＜ 0.05). The incidence of multiple organ dysfunction (MODS) and mortality in patients of the high-dose combined group and the low-dose combined group were lower than those in the ulinastatin group and the atomolam group (P＜ 0.05). Ulinastatin combined with atomolan is effective in the treatment of dyeability shock. It can effectively inhibit systemic oxidative stress and inflammatory reaction and improve the prognosis of patients, high dose ulinastatin combined with the treatment of septic shock is the best. [ABSTRACT FROM AUTHOR]

Mineral exploitation affects soil quality especially in the ecologically fragile areas the Loess Plateau. The quality of soil can be improved by vegetation restoration. In order to reveal the changes of soil quality in the process of vegetation restoration in the reclaimed land of mining, we took Heidaigou mining area and the surrounding natural vegetation restoration area as the research area, and selected 21 physicochemical indicators as the total data set (TDS). The minimum data set (MDS) was constructed by using principal component analysis (PCA) and Norm values. Two evaluation methods, non-linear (NL) and Linear (L), were used to evaluate the soil quality in this study area. The results show that the minimum data set include percentage of silt (Silt), organic matter (OM), available phosphorus (AP), sodium adsorption ratio (SAR) and microbial carbon (MBC). It indicates that in addition to conventional nutrients and physical properties, soil quality in this region is restricted by salinization and microbial biomass. The order of weight of MDS was: MBC (0.241) > OM (0.235) > AP (0.193) > Silt (0.174) > SAR (0.157). The applicability of the two evaluation methods is verified and we find that the overall spatial pattern of soil quality obtained by the two methods is similar, but there are still differences in details. According to the analysis results of the two evaluation methods, soil quality index (SQI) were all significantly improved by vegetation restoration (P < 0.05).Under different vegetation restoration types, the average value of the SQI-NL based on the MDS was sorted as follows: natural vegetation restoration land (NL, 0.587) > shrubs reclamation for 20 years (RLS 20, 0.479) > herbs reclamation for 12 years (RLH 12, 0.455) > shrubs reclamation for 10 years (RLS 10, 0.453) > herbs reclamation for 20 years (RLH 20, 0.424) > arbors reclamation for 20 years (RLA 20, 0.364) > and unreclaimed land (UL, 0.262) (P < 0.05), the average value of the SQI-L based on the MDS was sorted as follows: NL (0.522) > RLS 20 (0.444), > RLS 10 (0.412), > RLH 12 (0.401) > RLH 20 (0.400) > RLA 20 (0.326) > UL (0.228) (P < 0.05). In summary, different vegetation restoration years and different vegetation restoration types significantly improved the SQI of reclaimed land of mine areas (P < 0.05); however, the SQI of all reclaimed land has not reached that of natural vegetation restoration land, which indicates that the soil quality restoration of reclaimed land of mine areas is a long process. Since the SQI – NL method has a wider value range of SQI and coefficient of variation, this method has better applicability in this region than SQI-L, this is because 1) in the case of a wide range of soil quality index, the identification and classification accuracy of soil quality can be improved, which is conducive to the accurate evaluation of soil quality status and the timely detection of problems; 2) the coefficient of variation represents the sensitivity of SQI to changes in different environmental conditions, the higher the sensitivity of soil quality index to changes in environmental conditions is, the clearer the influence factors of soil quality change can be reflected, thus more effectively guiding the scientific management of soil quality improvement. Under the SQI-NL and SQI-L methods, the determination coefficients between MDS and TDS are 0.911 and 0.866, respectively, indicating that MDS can accurately replace TDS for soil quality evaluation. This study summarizes the MDS and soil quality evaluation methods suitable for the reclamation soil quality evaluation in the mining areas of the Loess Plateau, and recommends the future research and application in the same area and soil conditions. [ABSTRACT FROM AUTHOR]

Objective To explore and compare the physicochemical properties and in vitro enzymatic hydrolysis time of hyaluronic acid (HA) soft tissue filling agents. Methods Through experiments and available literature, the rheological, cohesive, supportive, modification, physicochemical properties, in vitro enzymatic hydrolysis, and micrographs of fifteen HA soft tissue filling agents commonly used in domestic and foreign markets were compared. Results Biphasic HA soft tissue filling agents had clear-cut particles, while monophasic HA fillers did not. Generally, biphasic HA soft tissue filling agents had larger G' and G" than monophasic HA soft tissue filling agents. There was no obvious pattern in the supportive properties. But for cohesiveness, monophasic products were significantly better than biphasic products. In vitro, enzymatic hydrolysis time and the degree of modification were significantly different between the brands of HA soft tissue filling agent and did not reflect dependence on monophasic/ biphasic products. Conclusion This study had important significance for guiding the design of a specific type of HA soft tissue filling agent and its rational application in clinic. [ABSTRACT FROM AUTHOR]

The antifungal mechanism of trans-cinnamaldehyde (TC) against Villosiclava virens was investigated. The alteration of cell ultrastructure was observed using transmission electron microscope. The integrity of cell wall and activities of nicotinamide adenine dinucleotide-malic dehydrogenase (NAD-MDHase), succinate dehydrogenase (SDHase) and adenosine triphosphatase (ATPase) of V. virens were determined after treated with TC at the mass concentration of 2, 4, 8, 15 and 30 μg/mL. The results showed that the contents of lipidosome increased significantly and the structure of mitochondrion was indiscernible after treatment with TC at the mass concentration of 4 μg/mL. With the mass concentration of TC increasing to 30 μg/mL, the integrity of cell wall in V. virens was destroyed and the relative inhibition of NAD-MDHase and SDHase were reduced by 44.3% and 76.7%, respectively. Differently, the activities of Na+-K+-ATPase, Ca2+-Mg2+-ATPase, Ca2+-ATPase and Mg2+- ATPase fluctuated as U-curve with the concentration increase of TC. When the mass concentration of TC was 4 μg/mL, the highest inhibitive activity of TC on ATPase was the achieved among all the tested concentrations and the relative inhibition of TC on ATPase was higher than 78.4%. These results suggested that the cell wall and mitochondrion were the possible action targets for TC to inhibit the mycelial growth. [ABSTRACT FROM AUTHOR]

Focusing on 15 different undecyl imidazoline corrosion inhibitors, a new method of combining random forest (RF) and multiple linear regression (MLR) was proposed to investigate the quantitative structure-inhibitive efficiency (IE) relationship. First, 15 corrosion inhibitors were comprehensively characterized by six aspects, which include energy, charge, molecular surface and information content, spatial and topological features, and 55 molecular structural features were achieved. Then RF and MLR were respectively employed to optimize these 55 features, so 8 overlapped parameters were selected from the top ten. Only 3 from 8 optimal features were randomly selected to construct the MLR model between the relationship of structure-/E. The optimal combination of features were molecular total energy (Te), information content (Ic) and molecular refractive index (Mr). Based on this, the optimal model of quantitative structure-inhibitive efficiency (IE) relationship was obtained, the correlation coefficient (R2) is 0. 843, the relational expression is IE= - 5. 517 - 0. 010 1Te+15. 601 7/c + 0. 222Mr. A singular sample was removed after the investigation of samples, its relative error reached 18. 9%. The remaining 14 samples were modeled, the performance of the model was obviously further improved with the R2 of 0. 911. The results indicate that Te, Ic and Mr all show the high positive correlation with IE. When the molecular structure is more stable, the symmetry is good, and the refractive index is high, then the IE value is higher. The model may be used as a theoretical reference for the design of new corrosion inhibitors. [ABSTRACT FROM AUTHOR]

The lignin of by-product in pulping production was mixed with asphalt by high-speed shearing process to prepare lignin modified asphalt. The mixing mechanism and the aging property of asphalt mixture were analyzed based on infrared spectrum (IR). The results show that compared with base asphalt property, the high temperature property and the temperature sensitivity of modified asphalt were improved. According to IR analyses of the blending of asphalt and lignin, the isolated components from modified asphalt and from blending treated by storage stability test, no new functional groups are produced during mixing, and it is only physical mixing. Based on IR quantitative analyses of carbonyl groups and sulfoxide groups, the lignin modified asphalt shows antioxidant effect and can slow aging process. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical efficacy of thalidomide combined with gefitinib in the treatment of non-small cell lung cancer. Methods: Selected 79 NSCLCpatients admitted to our hospital fromJanuary 2014 to December 2016. All patients were divided into control group (n=40) and observation group (n=39) by treatment methods. The control group received NSCLC routine treatment. The observation group was given thalidomide combined with gefitinib targeted therapy before surgery, then received routine treatment. The clinical efficacy, 6 months and 1 year survival rates between two groups were compared. The incidence of adverse reactions in the observation group was recorded. Results: The chemotherapy remission rate in the observation group (71.79 %) was significantly higher than that in the control group (52.50 %) (P<0.05). The patients in the observation group experienced various adverse reactions such as neutropenia, nausea and vomiting, joint pain, hair loss, and liver function impairment during the treatment period. Patients can tolerate the above symptoms, and they all relieve themselves after symptomatic treatment. The 6-month and 1-year survival rates in the observation group were significantly higher than those in the control group (P<0.05). Conclusions: Thalidomide combined with gefitinib is effective in the treatment of NSCLC patients and can significantly improve the survival rate of patients. It is worth further study. [ABSTRACT FROM AUTHOR]

以米糠蛋白（RBP）为碳源，采用水热合成法制备碳量子点，通过紫外-可见吸收光谱、荧光光谱、高分辨率透射电子显微镜（TEM）、傅里叶变换红外光谱(FTIR)对制备的米糠蛋白碳量子点（RBP-CDs）的光学性能、形貌结构及表面官能团进行表征，并探究RBP-CDs在不同环境下的稳定性及应用于传感、细胞成像、荧光染色等领域的效果。结果表明：RBP-CDs在286 nm下有紫外吸收峰，其发射波长具有激发依赖性；RBP-CDs的形状近似球形，分散性好，尺寸均一，粒径为2~4 nm；RBP-CDs表面富含羟基、羧基，亲水性好；在pH 4～10及不同盐浓度条件下，RBP-CDs的荧光性能良好；在365 nm紫外灯长时间照射下，也表现出良好的光学稳定性，但在不同化学环境中RBP-CDs的荧光强度差别较大，主要与其表面缺陷态有关。荧光传感实验表明，RBP-CDs可作为Fe3+的“Turn-Off”型荧光传感器，检出限可达15.2 nmol/L。RBP-CDs具有较低的细胞毒性，可用于HepG-2细胞的染色成像。RBP-CDs可作为一种新型荧光标记材料，应用于细胞标记和细胞成像领域。 The carbon dots (CDs) were prepared by hydrothermal method using rice bran protein(RBP) as the carbon source. The optical properties, morphology and surface functional groups of the prepared rice bran protein carbon dots (RBP-CDs) were characterized by UV-vis absorption spectrum, fluorescence spectrum, high-resolution transmission electron microscope (TEM) and Fourier transform infrared spectroscopy (FTIR), the stability of RBP-CDs in different environments and their application in sensing, cell imaging and fluorescent staining were investigated. The results showed that RBP-CDs had a UV absorption peak at 286 nm, and its fluorescence emission wavelength was excitation-dependent. RBP-CDs were approximately spherical with good dispersibility and the uniform size, mainly concentrated in 2-4 nm. The surface of RBP-CDs was rich in hydroxyl and carboxyl groups, so the hydrophilic property was better. In the pH 4-10 or high-salt environment, RBP-CDs had good fluorescence performance; under the long-term irradiation of 365 nm ultraviolet lamp, the fluorescence intensity did not change much, showing good optical stability; but the fluorescence intensity was different under different chemical environments, which was mainly related to the defect state of the RBP-CDs surface. The fluorescence sensing experiments showed that the RBP-CDs could be used as a “Turn-Off” fluorescence sensor for Fe3+, with a detection limit of 15.2 nmol/L,and it had lower cytotoxicity and could be used for staining and imaging of HepG-2 cells. RBP-CDs could be used as a new type of fluorescent labeling material for the cell labeling and cell imaging.

以玉米醇溶蛋白和乳清蛋白为原料，利用反溶剂共沉淀法制备玉米醇溶蛋白/乳清蛋白纤维核复合纳米粒，并与玉米油高速剪切制备Pickering乳液。探究了复合纳米粒在不同pH下的乳化性，以及复合纳米粒添加量对Pickering乳液粒径、微观形貌、储藏稳定性及流变学特性的影响。结果表明：玉米醇溶蛋白与乳清蛋白纤维核复合后乳化性显著提高，制备的Pickering乳液类型为水包油型；随着复合纳米粒添加量的增加，Pickering乳液粒径先减小后稍增大，添加量大于3 g（100 mL玉米油）后无显著性差异；在复合纳米粒添加量为4 g（100 mL玉米油）时，Pickering乳液油滴大小均一，储藏稳定性最好；Pickering乳液为假塑性流体，随复合纳米粒添加量的增加，表观黏度先减小后增大。 Using zein and whey protein as raw materials, the zein/whey protein fiber core complex nanoparticle were prepared by anti-solvent co-precipitation method and used for the preparation of corn oil loaded Pickering emulsions by high-speed shearing method. The emulsification property of complex nanoparticle was evaluated at different pH, and the effects of different nanoparticle dosages on the particle size, microscopic morphology, storage stability and rheological properties of Pickering emulsions were studied. The results showed that the emulsification property of zein/whey protein fiber core complex nanoparticle was significantly improved, and the prepared Pickering emulsions were oil-in-water emulsions. The particle size of Pickering emulsions reduced as the increase of complex nanoparticle dosage, and there was no significant difference above 3 g(100 mL corn oil). When the dosage was 4 g(100 mL corn oil), the Pickering emulsions had uniform oil droplets and the best storage stability. The Pickering emulsions were pseudoplastic fluid, and the apparent viscosity first decreased and then increased as the increase of complex nanoparticle dosage.

Grey relational analysis (GRA) is usually used to validate the simulation models because of its advantage in the field of time series relational analysis. The ordinary GRA stresses the similarity but ignores the proximity between two test time series while the proximity is part of model error. The grey relational degree given by a set of flight test sequences and a set of simulation test sequences is inconsistent with the practical problems of firing range. The ordinary GRA cannot be used in the overall performance evaluation of simulation model, which leads to a high risk of decision-making. An improved grey relational analysis is proposed to reduce the risk, in which the similarity and the proximity between the simulation test time series and the flight test time series are considered. At the same time it can analyze the time series which has not only one dimension but also more than one dimension by calculating probability sum, and so it fuses random factor of random process and makes full use of simulation test data with small sample flying test. Besides the new grey relational analysis improves the performance of GRA and has higher precision and reliability for the validation of simulation models. The proposed model can be used to solve the relational analysis problem with many characteristics of behavior, and the operational steps are listed in detail. Data test and case study are given to show the reasonability and validity of the improved method. [ABSTRACT FROM AUTHOR]