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8,179 results on '"Tang, Yan"'

864. 'Shutter' Effects Enhance Protein Diffusion in Dynamic and Rigid Molecular Networks

Author

Xiaobin Dai, Zhichao Zhu, Yujie Li, Bo Yang, Jiang-Fei Xu, Yuanchen Dong, Xin Zhou, Li-Tang Yan, and Dongsheng Liu

Subjects
Diffusion, Colloid and Surface Chemistry, Proteins, Hydrogels, DNA, General Chemistry, Biochemistry, Catalysis, Extracellular Matrix
Abstract

Hydrogels have been widely applied to understand the fundamental functions and mechanism of a natural extracellular matrix (ECM). However, revealing the high permeability of ECM through synthetic hydrogels is still challenged by constructing analogue networks with rigid and dynamic properties. Here, in this study, taking advantage of the rigidity and dynamic binding of DNA building blocks, we have designed a model hydrogel system with structural similarity to ECM, leading to enhanced diffusion for proteins compared with a synthetic polyacrylamide (PAAm) hydrogel. The molecular diffusion behaviors in such a rigid and dynamic network have been investigated both in experiments and simulations, and the dependence of diffusion coefficients with respect to molecular size exhibits a unique transition from a power law to an exponential function. A "shutter" model based on the rigid and dynamic molecular network has been proposed, which has successfully revealed how the rigidity and dynamic bond exchange determine the diffusion mechanism, potentially providing a novel perspective to understand the possible mechanism of enhanced diffusion behaviors in ECM.

Published
2022

865. Two episodes of Eocene mafic magmatism in the southern Lhasa terrane imply an eastward propagation of slab breakoff

Author

Wang, Zhenzhen, Zhao, Zhidan, Asimow, Paul D., Li, Xuping, Meng, Yuanku, Liu, Dong, Mo, Xuanxue, Zhu, Di-Cheng, Tang, Yan, and Cong, Fuyun

Subjects
Geology
Abstract

Past geodynamic events can be reconstructed using the spatial and temporal patterns of geochemical variability in igneous rocks. Here we apply this principle to define the timing and geometry of breakoff of the Neo-Tethyan slab after the India-Asia collision. Two episodes of mafic magmatism (∼53 Ma and ∼ 48 Ma) are preserved in the Quxu area of the southern Lhasa terrane (SL). We present their whole-rock geochemistry, zircon U-Pb ages, and in situ zircon Hf isotope ratios. The early gabbro (∼53 Ma) exhibits typical arc basalt characteristics, including enrichment of large-ion lithophile elements (LILEs), depletion of high-field strength elements (HFSEs), and radiogenic Nd and zircon Hf isotopes, implying that they were formed by partial melting of metasomatized lithospheric mantle. In comparison to the early gabbro, the late hornblende gabbro (∼48 Ma) contains higher contents of HFSEs (e.g., Nb, Zr) and relatively less radiogenic Nd and zircon Hf isotopes, suggesting interaction between the enriched sub-continental lithospheric mantle and asthenospheric mantle. It is likely that upwelling asthenosphere reached the central SL around 50 Ma and that the Neo-Tethyan slab tore off under this area at this time. The spatial and temporal distribution of mafic rocks across the whole southern Lhasa terrane show that this geochemical transition and hence, presumably, the tearing off of the Neo-Tethyan slab, propagated eastward along the collision zone throughout Paleocene-Eocene time.

Published
2022

866. Predictive Factors for Failure of Noninvasive Ventilation in Adult Intensive Care Unit: A Retrospective Clinical Study

Author

Qimin Chen, Ming Liu, Bo Liu, Wei Li, Daixiu Gao, Lulu Xie, Yu Wu, Liang Li, Ying Liu, Ying Wang, Tang Yan, Yuanyi Liu, Yumei Cheng, Xu Liu, and Feng Shen

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Background. Noninvasive ventilation (NIV) has been reported to be beneficial for patients with acute respiratory failure in intensive care unit (ICU); however, factors that influence the clinical outcome of NIV were unclarified. We aim to determine the factors that predict the failure of NIV in critically ill patients with acute respiratory failure (ARF). Setting. Adult mixed ICU in a medical university affiliated hospital. Patients and Methods. A retrospective clinical study using data from critical adult patients with initial NIV admitted to ICU in the period August 2016 to November 2017. Failure of NIV was regarded as patients needing invasive ventilation. Logistic regression was employed to determine the risk factor(s) for NIV, and a predictive model for NIV outcome was set up using risk factors. Results. Of 101 included patients, 50 were unsuccessful. Although more than 20 variables were associated with NIV failure, multivariate logistic regression demonstrated that only ideal body weight (IBW) (OR 1.110 (95%1.027–1.201), P=0.009), the maximal heart rate during NIV period (HR-MAX) (OR 1.024 (1.004–1.046), P=0.021), the minimal respiratory rate during NIV period (RR-MIN) (OR 1.198(1.051–1.365), P=0.007), and the highest body temperature during NIV period (T-MAX) (OR 1.838(1.038–3.252), P=0.037) were independent risk factors for NIV failure. We set up a predictive model based on these independent risk factors, whose area under the receiver operating characteristic curve (AUROC) was 0.783 (95% CI: 0.676–0.899, P

Published
2020
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877. Efficacy and safety of keverprazan compared to lansoprazole in the treatment of duodenal ulcer: a phase III, randomised, double-blind, multicentre trial

Author

Tan, Nian-di, primary, Miao, Xin-pu, additional, Liao, Ai-jun, additional, Liu, Cheng-xia, additional, Wu, Hao, additional, Chen, Hong-hui, additional, Li, Fang-fang, additional, Guo, Qing-hong, additional, Li, Sheng-bao, additional, Tang, Yan-ping, additional, Xia, Min, additional, Liu, You-li, additional, Li, Xing, additional, Chen, Hui-xin, additional, Liu, Xiao-wei, additional, Zhang, Yan, additional, Zhang, Zhen-yu, additional, Chen, Min-hu, additional, and Xiao, Ying-lian, additional

Published
2023
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881. Differentiation syndrome and coagulation disorder — comparison between treatment with oral and intravenous arsenics in pediatric acute promyelocytic leukemia

Author

Luo, Jie-Si, primary, Zhang, Xiao-Li, additional, Huang, Dan-Ping, additional, Chen, Yi-Qiao, additional, Wan, Wu-Qing, additional, Mai, Hui-Rong, additional, Chen, Hui-Qin, additional, Wen, Hong, additional, Liu, Ri-Yang, additional, Chen, Guo-Hua, additional, Li, Yu, additional, Luo, Xue-Qun, additional, Tang, Yan-Lai, additional, and Huang, Li-Bin, additional

Published
2023
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888. Dietary ferulic acid supplementation improves antioxidant capacity and lipid metabolism in liver of piglets with intrauterine growth retardation

Author

Wu, Xiu, primary, Liang, Hongmin, additional, Tang, Yan, additional, Chen, Daiwen, additional, Yu, Bing, additional, He, Jun, additional, Mao, Xiangbing, additional, Huang, Zhiqing, additional, Yan, Hui, additional, Wu, Aimin, additional, Luo, Yuheng, additional, Zheng, Ping, additional, Yu, Jie, additional, Pu, Junning, additional, and Luo, Junqiu, additional

Published
2023
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894. Retraction notice to “Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via PKC/ERK/c-Fos pathways in RAW264.7 macrophages” [Biochimie 119C (2015) 192–203]

Author

Peng, Juan, primary, Lv, Yun-Cheng, additional, He, Ping-Ping, additional, Tang, Yan-Yan, additional, Xie, Wei, additional, Liu, Xiang-Yu, additional, Li, Yuan, additional, Lan, Gan, additional, Zhang, Min, additional, Zhang, Chi, additional, Shi, Jin-Feng, additional, Zheng, Xi-Long, additional, Yin, Wei-Dong, additional, and Tang, Chao-Ke, additional

Published
2023
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