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Fifty cases of extensive and necrotizing perineal cellulitis ("perineal gangrene") are reported. The disease, remarkable for its many anatomical and bacteriological varieties, is regarded as a therapeutic requiring multidisciplinary management. Bacteriological samples were polymicrobial in 40 cases. Streptococcus D and aerobic Gram-negative bacilli were isolated in 21 patients. The initial antibiotic treatment had to be modified on ten occasions in 36 patients who were given penicillin G in high doses and on five occasions in 14 patients who received a beta-lactam antibiotic active against anaerobes. Nineteen patients (38 p. 100) died; death was directly related to the sepsis in 16 cases. The death rate was the same in the two treatment groups (11/36 and 5/14) and similar to that found in the literature. The authors advocate an ureidopenicillin, fosfomycin and imidazole combination as a substitute for the conventional penicillin G, aminoglycoside, imidazole combination, since the former is active against Streptococcus D and has better tissue penetration.

Twenty patients with severe nosocomial bacterial infections hospitalized in an intensive care unit were treated by ceftriaxone alone, in a single daily IV injection of 2 g. Clinical and bacteriological results show that ceftriaxone has good activity against enterobacteria. The four patients (20%) who failed to respond had superinfection by Pseudomonas aeruginosa, a finding that suggests that ceftriaxone should be used in combination with another antibiotic for the treatment of nosocomial infections. Pharmacokinetic results in our patients show that with the dosage used peak and trough serum levels are greater than the MICs of susceptible pathogens.

The authors report a case of Staphylococcus epidermidis prosthetic valve endocarditis. After two unsuccessful treatments, the association Gentamicin-Fosfomycin provided adequate serum bactericidal titers and had a good efficacy.

We investigated bactericidal activity of four disinfectants against mycobacterium smegmatis and others mycobacteria species such as those responsible for respiratory and lymphadenitis diseases. We used the germ carried method according to all the AFNOR requisites changing only the strains culture conditions and for some studies time of contact (15 and 30 minutes). In addition we realized a preliminary essay to control efficacy of washing in order to maximally eliminate the product after the time of contact. Under AFNOR standard conditions (15 minutes) only phenolic complex and glutaraldehyde solution were bactericidal for all strains including M. tuberculosis. Another series of test with contact during 30 minutes showed that with aldehyde and quaternary ammonium compounds bactericidal activity was limited against M. fortuitum and M. chelonei and nearly non existent at usual concentrations against M. kansasii, M. avium and M. tuberculosis.

The aim of this study is to display the repairing mechanisms to happen when the gingival epithelium is hurt by dental eruption or extraction. The experimentation has been managed on rats, using scanning electronic microscopy.

A standard hand-washing technique was used in order to test the relative effectiveness of eight both detergent and alcoholic preparations intended to surgeon's hands disinfection. A single four or seven minutes washing with alcoholic solutions was shown to eliminate a much larger proportion of the skin flora than could be removed by a single four or seven minutes hand-washing with detergent antiseptic preparations. Authors have also determined effect of wearing surgical rubber gloves after skin disinfection and compared viable bacterial counts in hand washings immediately after the antiseptic treatment and when gloves had been worn for one hour.

Concentrations of a disinfectant complex effective against hospital strains were determined using the dilution-neutralization method (AFNOR T72 150). Results were compared to those obtained with reference bacterial strains. A 99.999% reduction in viable bacteria requires significantly higher concentrations for hospital isolates than for reference strains.

The morphogenesis of elastic fibers in human, fetal and adult vocal cords was studied by light microscopy and transmission electron microscopy. The elastic system includes elastic, elaunin and oxytalan fibers at different stages. The development of elastic-system fibers in human vocal cord is characterized by every stage of maturation, whether normal, stifled or accelerated, according to areas.