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In this paper, we apply a numerical integration strategy recently developed for determining the deformation shapes of structures constituted by Cosserat rods, to predict the behavior of panto-cylinders. Panto-cylinders have, as microstructure, a set of two families of helicoidal beams interconnected by perfect or elastic joints. The pivot's free rotation axis is, in the reference configuration, orthogonal to the cylindrical surfaces spanned by the beams. We perform a series of numerical simulations looking for the mechanical parameters which exalt the chirality effects in the structure. For the performed compression, extensions, shear, and torsion tests, we find chiral deformation patterns with a dependence on the type of joint and its length. [ABSTRACT FROM AUTHOR]

Conditions for regular domain structure formation in a single-crystal barium hexaferrite plate have been studied experimentally. The purpose of the work was to develop a simple and, at the same time, an effective method of regularizing the cylindrical domain structure in these plates. The cylindrical domain structure was created by the field method, and its visualization was carried out using the Faraday effect. Radiophysical method of microwave spectroscopy was used to study characteristics of the spectra of magnetostatic oscillations, which are uniquely related to the type and quality of the formed domain structure. The method of cylindrical domain structure regularization in single-crystal barium hexaferrite has been proposed, which is based on applying a constant fixed magnetic field along the easy magnetization axis. It has been ascertained that the optimal value of regularization field lies within the range 3.3...3.6 kOe. However, with the fields exceeding 3.6 kOe, the cylindrical domain structure is significantly distorted. It was found out that the proposed method allows increasing the intensity of the most high-frequency domain magnetostatic resonance by more than 4.5 dB. [ABSTRACT FROM AUTHOR]

[Display omitted] • Ranunculus prefers drainage conditions, i.e., upward flow in hyporheic zone. • Developing Ranunculus modifies hydraulic properties of the riverbed. • Ranunculus clumps decreased filtration flow in the hyporheic zone five-fold. • Ranunculus habitats must be managed properly to remain in a healthy state. • Recognition of hyporheic flows is required in Ranunculus habitat conservation. The study attempted to assess the influence of the filtration stream and hydraulic gradient in the hyporheic zone on the distribution of water crowfoot (Ranunculus sect. Batrachium) in common temperate lowland river type in two European ecoregions: (14) Central Plains and (16) Eastern Plains. A novel filtrometer and a gradient meter were employed for water flow measurements in the hyporheic zone at 24 study sites distributed throughout Central Europe between 2017 and 2019. At the majority of the study sites, hyporheic zones covered with Ranunculus vegetation were found to be dominated by groundwater drainage. Moreover, the intensity of groundwater filtration supplied via the hyporheic zone varied, ranging from 0.0017 m3 d−1·m−2 to 0.4118 m3 d−1·m−2. It was also determined that the average stream of filtration in the non-vegetated parts of the riverbed was 0.6065 m3 d-1·m−2, whereas it was five times lower in the zones overgrown with Ranunculus clumps, amounting to 0.1190 m3 d−1 m−2. The study provides quantification of the interactions between water exchange in the hyporheic zone and the growth and distribution of Ranunculus species, indicating that the exchange of surface water and groundwater is an important environmental factor that stimulates the growth of various Ranunculus taxa. The study provides evidence for a new environmental indicator, specifically the importance of surface water and groundwater exchange in the hyporheic zone of rivers for Ranunculus vegetation conservation and for planning and implementing nature-based river management methods. [ABSTRACT FROM AUTHOR]

The main aim of the work was the experimental and numerical analysis of the energy absorption/dissipation capabilities and failure mechanisms of novel hyper-elastic target material intended for ballistic applications including layers of composite armors, projectile catching systems and anti-ricochet layers covering walls of shooting ranges, ballistic tunnels, etc. Static and dynamic mechanical properties of the material were analyzed at both room and elevated temperatures ( 40 ÷ 80 ∘ C ). Numerical models of the material and 7.62 × 25 mm FMJ projectile were defined. Simulations of the hyper-elastic target penetration with the projectile were carried out. The differences between the results obtained numerically and experimentally were determined (measured as a relative error) and were lower than 15% what testified about proper definition of the numerical models of the analyzed phenomenon components. [ABSTRACT FROM AUTHOR]

Analyses of the human bones failure mechanisms under projectile impact conditions can be made through performing of a large number of ballistic trials. But the amount of data that can be collected during ballistic experiments is limited due to the high dynamics of the process and its destructive character. Numerical analyses may support experimental methodologies allowing to better understand the principles of the phenomenon. Therefore, the main aim of the study was to create and to verify a numerical model of commercially available synthetic bone material—Synbone®. The model could be used in the future as a supporting tool facilitating forensic studies or designing processes of personal protection systems (helmets, bulletproof vests, etc.). Although Synbone® is commonly used in the ballistic experiments, the literature lacks reliable numerical models of this material. In order to define a numerical model of Synbone®, mechanical experiments characterizing the response of the material to the applied loads in a wide range of strains and strain rates were carried out. Based on the mechanical tests results, an appropriate material model was selected for the Synbone® composite and the values of constants in its equations were determined. Material characterization experiments were subsequently reproduced with numerical simulations and a high correlation of the results was obtained. The final validation of the material model was based on the comparison of the ballistic impact experiments and simulation results. High similarity obtained (relative error lower than 10%) demonstrates that the numerical model of Synbone® material was properly defined. [ABSTRACT FROM AUTHOR]

The change in the flow of plain rivers in Kazakhstan in recent decades is done due to the influence of both climatic factors and anthropogenic impacts. Revealing their role is extremely important for understanding the genesis of hydrological changes that have already occurred and possible in the future, as well as for taking measures to reduce their undesirable consequences. The complexity of solving this problem lies in the fact that climatic and anthropogenic changes in river runoff are closely interrelated and often interact on the runoff not directly, but indirectly. The intensity of anthropogenic impact, the variability of climate characteristics determine changes in the hydrological regime of water bodies. Climatic variability leads to an increase in the likelihood of adverse hydrometeorological phenomena, and human economic activity in the watershed and in the riverbed leads to a quantitative and qualitative change in the main characteristics of the hydrological regime, degradation of river ecosystems. The changes in the annual runoff of plain rivers are estimated based on the method based on the restoration of the natural runoff of the last decades, during which significant anthropogenic changes took place. It is shown that climatic and anthropogenic factors act on the runoff both unidirectionally, increasing or decreasing it, and in opposite directions. At the same time, the influence of anthropogenic factors, mainly reservoirs and water consumption, is commensurate with the influence of climatic factors, and in many cases exceeds it. [ABSTRACT FROM AUTHOR]

[Display omitted] • Remote sensing-based approach to indicate vertical displacement of the peat. • Annual peatland subsidence in the Biebrza Valley peatlands = 1.44 cm. • Verifying this approach vs. field observations (R2 = 0.7, RMSE = 0. 23 cm) • ∼ 46 tones of peat per hectare lost per annum. • Subsidence due to artificial drainage and climate change at the regional scale. Peatlands play a crucial role in carbon storage, but drainage and climate change-induced hydrological changes drivers degrade peat soils, followed by negative vertical displacement of the soil surface, referred to in the literature as peat subsidence. Assessing peatland subsidence is an important indicator of peatland status that allows the development of peatlands to be revealed over a given period. However, traditional methods are limited in their applicability to large and inaccessible peatlands. In this study, we introduce a remote sensing framework for easily indicating peat subsidence at a large scale. Our framework utilizes the Alaska Satellite Facility (ASF) Interferometry Synthetic Aperture Radar (InSAR) with on-demand cloud computing, employing an optimization process including a Small Baseline Set technique and seasonal-annual search approach. By implementing this approach in the Biebrza Valley, Poland, covering the period from April 2015 to April 2022, we unveiled a tragedy, an annual subsidence rate of 1.44 cm. It means a peat loss between 58.1 and 89.6 million cubic meters over seven years, an annual loss of 86.4 to 132.5 (average 109) m3, approximately 46 tons, of dry matter peat per hectare. This finding was verified through field surveys, with high accuracy. An R2 value of 0.7, and an RMSE value of 0.23 cm determine the reliability of this approach in estimating the vertical displacement. The potential of this tool as a robust method to assess large-scale peatlands would allow for the assessment of average water levels as well as greenhouse gas emissions over large areas of peatlands, even at the continental scale. [ABSTRACT FROM AUTHOR]

Effectiveness of simplified modeling methods of ballistic inserts containing high-strength para-aramid fabrics under projectile impact condition was analyzed in the article. Various types of experimental tests including material characterization and ballistic impact were carried out in order to define and to validate numerical models of the individual components of the analyzed phenomenon. Experiments were subsequently reproduced with numerical simulations. Four different modeling techniques were used to describe the fabric layers, i.e.: shell elements, solid elements merged or detached at shared nodes and beam elements representing packs of individual fibers. The effectiveness of the individual methods was compared in terms of quality (mapping of characteristic phenomena that occur during the penetration process), quantity (dimensions of deformations of components, number of perforated fabric layers) and time required to complete the calculations. On the basis of the analysis results it was concluded that hybrid method of modeling of yarns of the fabric in which principal yarns were modeled with solid elements attached at nodes was the most effective. Such approach allowed to accurately reproduce the response of the yarns to the acting loads without significant increase of time required to complete the calculations. [ABSTRACT FROM AUTHOR]

• Inter-seasonal DGLF aligns with precipitation, revealing shifts in plant reliance. • Changing phreatophytes-induced cone of depression influences DGLF at landscape edges. • Proximity to peat-mineral interface shapes high-amplitude DGLF due to a pressure buffer. • River proximity dampens DGLF, validating hydraulic gradient influence at the hyporheic. Diurnal groundwater level fluctuations (DGLF), closely tied to the metabolic rhythm of wetland vegetation, offer insights into direct groundwater consumption. This study is centered on exploring the spatial and temporal patterns of DGLF within the riparian aquifer of the Upper Biebrza region, motivated by the need to understand those sub-daily ecohydrological dynamics at play in this ecosystem, on a process-oriented scale. Through integrated spatiotemporal multivariate analysis, we aim to identify the key potential factors driving variations in these fluctuations across the landscape gradient, as well as, at different time scales. The study employed a comprehensive approach to gather data on groundwater heads and direct groundwater fluxes, utilizing high-temporal-resolution wells within a monitoring network. Meteorological variables from a dedicated station and high-resolution remote sensing maps were also integrated into the dataset. Analysis revealed distinct seasonal patterns and correlations in diurnal groundwater fluctuations, closely correlated with air temperature, solar radiation and subsequently vegetation phenology. Soil moisture content and summer rainfall events also influenced the intensity of these diurnal fluctuations. Dry periods intensified fluctuations, indicating an elevated reliance on groundwater by phreatophytes, while fluctuations decreased after rainfall events, signaling a shift in vegetation's water source preference to soil moisture. Based on integrated data interpretation, a couple of potential mechanisms, reasonably forming the spatial variation pattern of DGLF, were formulated. Notably, the influence of local hydraulic gradients at transitional forest landscape edges, where higher amplitude fluctuations occurred, compared to lower fluctuations at midpoints. The proximity to the peat-mineral interface influences diurnal fluctuations, with wells closer to the interface showing sustained high-amplitude fluctuations driven by higher rates of recharge. Additionally, the influence of river proximity was explored, revealing dampened fluctuations in wells closer to the river due to rapidly changing hydraulic gradients. Further systematic experimentation, including numerical and data-driven modeling, is needed to validate these hypotheses. The study findings provide perspectives into (DGLF) patterns and distributions, enabling more accurate groundwater evapotranspiration (ETg) estimation and opening new avenues for considering ecohydrological feedback regarding carbon–water interaction, in relation to the daily-scale water table position. [ABSTRACT FROM AUTHOR]

Acute myeloid leukemia (AML) with fetal liver tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) is associated with poor prognosis, and allogeneic stem cell transplantation (Allo-SCT) seems to be the preferred therapeutic approach. However, the predictors of post-transplant outcomes were not well-defined. The aim of the study was to evaluate the significance of FLT3/ITD mutation by polymerase chain reaction as minimal residual disease (MRD) marker of outcomes after transplantation. We identified 43 patients (28 females and 15 males) with FLT3-mutated AML at the median age of 45 years who were allografted between 2009 and 2019. Hematological status at transplant was as follows: the first complete remission (CR1) in 29 patients, CR2 in 5, and 9 patients were transplanted in marrow aplasia (MA). Twenty-seven patients were FLT3 MRD negative at transplant. Median time from diagnosis to transplant was 16.7 months. Post-allograft CR rate was 88%. The relapse incidence (RI) was lower for patients who were FLT3 MRD negative at transplant when compared with those with FLT3 MRD positivity (41% vs 59%; p = 0.01). The patients who eradicated FLT3/ITD at day + 30 after transplant had lower RI than those with detectable FLT3/ITD (23% vs 76%; p = <0.001). The 2-year LFS and OS were 53% and 54%, with the median OS and LFS of 28 months and 27 months, respectively. Patients with CR1/2 and FLT3 MRD(-) had a 2-year OS of 80%. The FLT3 MRD negativity at transplant prolonged LFS in multivariate analysis (HR 5.3 95%CI 1.97-14.2); p < 0.001), whereas FLT3 MRD negativity and unrelated donor predicted favorable OS. [ABSTRACT FROM AUTHOR]

Mesotrophic rich fens, that is, groundwater-fed mires, may be long-lasting, as well as transient ecosystems, displaced in time by poor fens, bogs, forests or eutrophic reeds. We hypothesized that fen stability is controlled by plant stress caused by waterlogging with calcium-rich and nutrient-poor groundwater, which limits expansion of hummock mosses, tussock sedges and trees. We analysed 32 European Holocene macrofossil profiles of rich fens using plant functional traits (PFTs) which indicate the level of plant stress in the environment: canopy height, clonal spread, diaspore mass, specific leaf area, leaf dry matter content, Ellenberg moisture value, hummock-forming ability, mycorrhizal status and plant functional groups. Six PFTs, which formed long-term significant trends during mire development, were compiled as rich fen stress indicator (RFSI). We found that RFSI values at the start of fen development were correlated with the thickness of subsequently accumulated rich fen peat. RFSI declined in fens approaching change into another mire type, regardless whether it was shifting into bog, forest or eutrophic reeds. RFSI remained comparatively high and stable in three rich fens, which have not terminated naturally until present times. By applying PFT analysis to macrofossil data, we demonstrated that fens may undergo a gradual autogenic process, which lowers the ecosystem's resistance and enhances shifts to other mire types. Long-lasting rich fens, documented by deep peat deposits, are rare. Because autogenic processes tend to alleviate stress in fens, high levels of stress are needed at initial stages of rich fen development to enable its long persistence and continuous peat accumulation. [ABSTRACT FROM AUTHOR]

Peatlands are poorly represented in global Earth system modeling frameworks. Here we add a peatland‐specific land surface hydrology module (PEAT‐CLSM) to the Catchment Land Surface Model (CLSM) of the NASA Goddard Earth Observing System (GEOS) framework. The amended TOPMODEL approach of the original CLSM that uses topography characteristics to model catchment processes is discarded, and a peatland‐specific model concept is realized in its place. To facilitate its utilization in operational GEOS efforts, PEAT‐CLSM uses the basic structure of CLSM and the same global input data. Parameters used in PEAT‐CLSM are based on literature data. A suite of CLSM and PEAT‐CLSM simulations for peatland areas between 40°N and 75°N is presented and evaluated against a newly compiled data set of groundwater table depth and eddy covariance observations of latent and sensible heat fluxes in natural and seminatural peatlands. CLSM's simulated groundwater tables are too deep and variable, whereas PEAT‐CLSM simulates a mean groundwater table depth of −0.20 m (snow‐free unfrozen period) with moderate temporal fluctuations (standard deviation of 0.10 m), in significantly better agreement with in situ observations. Relative to an operational CLSM version that simply includes peat as a soil class, the temporal correlation coefficient is increased on average by 0.16 and reaches 0.64 for bogs and 0.66 for fens when driven with global atmospheric forcing data. In PEAT‐CLSM, runoff is increased on average by 38% and evapotranspiration is reduced by 19%. The evapotranspiration reduction constitutes a significant improvement relative to eddy covariance measurements. Plain Language Summary: Peatlands are wetlands in which plant matter has accumulated over thousands of years under almost permanently water‐logged conditions. Alterations in these conditions as a result of global climate change can lead to the release of the huge peatland carbon pool as carbon dioxide over much shorter timescales than were required for accumulation. The additional emissions would amplify global warming. A better representation of the peatland hydrology in global Earth system models can help quantify how peatlands respond to a changing climate. In this paper, we add a peatland‐specific land surface hydrology module to the land surface model used in NASA's GEOS Earth system modeling framework. Comparisons of numerical simulations encompassing northern peatlands against field observations show that the new model version significantly improves our ability to capture the hydrological dynamics of peatlands. The new peatland representation in GEOS offers new opportunities, including the potential for merging model information and remote sensing observations in a way that improves our understanding of the overall role played by peatlands in the global water and carbon cycles. Key Points: A peatland‐specific land surface hydrology was added to an Earth system model and constrained by literature data, without parameter tuningSimulations were evaluated with a data set of groundwater table depth and evapotranspiration with unprecedented coverage in high latitudesThe peatland model version performs significantly better in terms of hydrological variables over peatlands than the operational model [ABSTRACT FROM AUTHOR]

In this paper, we account for the research efforts that have been started, for some among us, already since 2003, and aimed to the design of a class of exotic architectured, optimized (meta) materials. At the first stage of these efforts, as it often happens, the research was based on the results of mathematical investigations. The problem to be solved was stated as follows: determine the material (micro)structure governed by those equations that specify a desired behavior. Addressing this problem has led to the synthesis of second gradient materials. In the second stage, it has been necessary to develop numerical integration schemes and the corresponding codes for solving, in physically relevant cases, the chosen equations. Finally, it has been necessary to physically construct the theoretically synthesized microstructures. This has been possible by means of the recent developments in rapid prototyping technologies, which allow for the fabrication of some complex (micro)structures considered, up to now, to be simply some mathematical dreams. We show here a panorama of the results of our efforts (1) in designing pantographic metamaterials, (2) in exploiting the modern technology of rapid prototyping, and (3) in the mechanical testing of many real prototypes. Among the key findings that have been obtained, there are the following ones: pantographic metamaterials (1) undergo very large deformations while remaining in the elastic regime, (2) are very tough in resisting to damage phenomena, (3) exhibit robust macroscopic mechanical behavior with respect to minor changes in their microstructure and micromechanical properties, (4) have superior strength to weight ratio, (5) have predictable damage behavior, and (6) possess physical properties that are critically dictated by their geometry at the microlevel. [ABSTRACT FROM AUTHOR]

In the pathway inhibitor era, the number of allogeneic stem cell transplantation (ASCT) for chronic lymphocytic leukemia (CLL) continues to decrease and this approach should be offered only after careful risk-benefit assessment. Nevertheless, ASCT still remains only curative therapeutic modality for CLL, especially in countries with limited access to novel agents. Thirty patients with CLL at median age of 42 years at diagnosis (range 29-64) underwent ASCT between years 2002 and 2018. Thirteen patients were transplanted in complete remission (CR), ten patients achieved partial response (PR), and seven had stable disease. The median time from diagnosis to transplant was 4 years (range 0.5-12). Twenty-three patients received HLA-matched related donor stem cell grafts, and seven patients received either matched unrelated donor or HLA-mismatched grafts. Reduced intensity conditioning (RIC) and myeloablative regimen (MAC) were used in 24 and 6 patients, respectively. Mortality to day + 100 after transplant was 16% (8% for RIC only). Acute and chronic graft versus host disease (GVHD) developed in 40% and 63% of patients, respectively. Fifteen patients relapsed or progressed after transplant. Thirteen patients (43%) are alive at last follow-up and 10 (77%) remain in clinical CR. Median follow-up for survivors was 6.8 years (range 0.4-15.2). Three-year progression-free and overall survivals were 56% and 60%, respectively. These outcomes were better for patients who received RIC conditioning: 64% and 72%, respectively. CR at transplant was found to have favorable impact on post-allograft survival. RIC should be preferred over MAC. ASCT may remain a valuable option for some CLL patients. [ABSTRACT FROM AUTHOR]

Low-frequency mowing has been proposed to be an effective strategy for the restoration and management of boreal fens after abandonment of traditional haymaking. This study investigates how mowing affects long-term vegetation change in both oceanic and continental boreal rich-fen vegetation. This will allow evaluation of the effectiveness of mowing as a management and restoration tool in this ecosystem in the face of climate change. At two nature reserves in Central Norway (Tågdalen, 63° 03’ N, 9° 05 E, oceanic climate and Sølendet, 62° 40’ N, 11° 50’ E, continental climate), we used permanent plot data from the two sites to compare plant species composition from the late 1960s to the early 1980s with that recorded in 2012–2015 in abandoned and mown fens. Changes in species composition and frequency were analysed by multivariate and univariate methods in relation to environmental variables and modelled climate and groundwater data. Mowing resulted in a decline in shrub and Molinia caerulea cover at the continental and oceanic sites respectively, and the total cover of specialist fen species had increased to a significantly greater extent in the mown plots than the unmown at the continental site. However, mowing did not have an effect on the cover of specialist bryophyte species, and some specialist species declined regardless of mowing treatment. Temperature sums had increased at both sites, but precipitation had not changed significantly. Mowing was shown to be the most important determinant of plant community composition at both sites, with local environmental conditions being of secondary importance. In conclusion, the abandonment of traditional management practices results in the loss of characteristic fen species. In order to encourage the restoration of typical rich-fen vegetation, particularly in oceanic areas, additional management measures, such as more intensive mowing, may be required. [ABSTRACT FROM AUTHOR]

Due to the latest advancements in 3D printing technology and rapid prototyping techniques, the production of materials with complex geometries has become more affordable than ever. Pantographic structures, because of their attractive features, both in dynamics and statics and both in elastic and inelastic deformation regimes, deserve to be thoroughly investigated with experimental and theoretical tools. Herein, experimental results relative to displacement-controlled large deformation shear loading tests of pantographic structures are reported. In particular, five differently sized samples are analyzed up to first rupture. Results show that the deformation behavior is strongly nonlinear, and the structures are capable of undergoing large elastic deformations without reaching complete failure. Finally, a cutting edge model is validated by means of these experimental results. [ABSTRACT FROM AUTHOR]

While traditional forest management systems aim at maximizing timber production, sustainable forest management focuses on the multiple benefits of entire forest landscapes. The latter is now at the top of policy agendas. This calls for learning through evaluation to support the implementation of policies aiming towards multi-functional forest landscapes. The aim of this study is to quantify the economic trade-offs among natural, current, and re-wetted peatland forests using seven indicators, viz. drainage maintenance, rewetting, water retention, wood production, and three types of carbon sequestration as economic indicators. We discuss ways to adapt to and mitigate effect of forest draining on climate change toward securing multi-functional forest landscapes. The cost benefit analysis showed that in a potential natural state, Lithuania's peatland forests would deliver an economic benefit of ∼€176.1 million annually. In contrast, compared to natural peatland forests, the drainage of peatland forests for wood production has caused a loss of ∼€309 million annually. In comparison, peatland forest rewetting is estimated to increase the economic value by ∼€170 million annually. This study shows that satisfying different ecosystem services is a balancing act, and that a focus on wood production has resulted in net losses when foregone values of water storage and carbon sequestration are considered. Valuation of different sets of ecosystems service benefits and disservices must be assessed, and can be used as a tool towards creating, implementing and monitoring consequences of policies on both sustainability and biodiversity. [Display omitted] • Lithuanian drained peatland forests accrue losses of ∼€309 Million annually. • Landowner should not be economically or socially deprived by re-wetting peatlands. • Multifunctional forest landscapes require valuation of various ecosystems services. • Managing different portfolios of ecosystem services is a balancing act. [ABSTRACT FROM AUTHOR]

Intensification of agriculture and ongoing urban sprawl exacerbate pressures on rivers. Small rivers in agricultural landscapes are especially exposed to excessive technical actions implemented in order to allow for harvesting river water for irrigation, draining agricultural water and receiving sewage. Regular dredging and macrophyte removal strongly interfere with the global need for preserving river biodiversity that allows agricultural lowland rivers to remain refuges for a variety of species, and—accordingly—to keep water bodies resilient for the benefit of society. In order to provide a comprehensive look at the influence of agricultural lowland river management on the ecological status of these water bodies, we conducted a literature review and a meta-analysis. For the structured literature review we selected 203 papers reflecting on the response of aquatic ecosystems to dredging and macrophyte management actions. The database of scientific contributions developed for our study consists of papers written by the authors from 33 countries (first authorship) addressing dredging, macrophyte removal, status of fish and macroinvertebrates as well as the general ecological status of lowland agricultural rivers. We revealed that 96% of the analyzed papers indicated unilateral, negative responses of aquatic ecosystems, particularly macroinvertebrates, ichthyofauna and macrophyte composition, to maintenance measures. We revealed that studies conducted in the European Union on the ecological status of rivers appeared to significantly increase in quantity after the implementation of the Water Framework Directive. Finally, we concluded that day-to-day management of lowland agricultural rivers requires revision in terms of compliance with environmental conservation requirements and the recurrent implementation of technical measures for river maintenance. [ABSTRACT FROM AUTHOR]

Observational data on greenhouse gases exchange between ecosystems and the atmosphere are crucial in understanding the global climate mechanisms. Among different methods of estimation of this exchange, the eddy-covariance (EC) technique provides a direct measure of the net flux density across the atmosphere-ecosystem interface. Still, such data are highly scarce for Central European wetlands. In this work, we present the results of two years (2013–2014) of continuous open-path EC measurements of methane (CH 4 ) and carbon dioxide (CO 2 ) fluxes at the wetlands of the Biebrza National Park in northeastern Poland – one of the biggest coherent lowland wetland area in Central Europe. The measurement site (53°35′30.8″N, 22°53′32.4″E) was located near the Kopytkówka river in a fen peatland, whose soils are slightly decomposed due to dehydration. The mean annual sum of CH 4 release equaled 29 ± 4 g CH 4 m −2 yr −1 in wetter year 2013 and 20 ± 1 g CH 4 m −2 yr −1 in drier year 2014. The mean annual uptake of CO 2 reached 980 ± 150 g CO 2 m −2 yr −1 and 560 ± 130 g CO 2 m −2 yr −1 in 2013 and 2014, respectively. Both fluxes show a clear annual pattern with maximum CH 4 release in June and July (at a level of 130 nmol m −2 s −1 ) and maximum CO 2 uptake in June (at a level of 4.2 μmol m −2 s −1 ). The considerable C–CO 2 uptake in comparison to C–CH 4 emissions suggests that the Biebrza river wetlands are a significant carbon sink, but the net contribution of the Biebrza mires to the climate forcing is unclear because of different metrics which can be used to specify the relative weights of CO 2 and CH 4 . [ABSTRACT FROM AUTHOR]

Highlights: [•] Bortezomib-based regimens were evaluated in 708 relapsed/refractory myeloma pts. [•] The ORR was 67.9% for refractory and 69.9% for relapsed MM. [•] The median PFS was 14 months and OS 57 months. [•] Patients responding to the therapy had the probability of a 4-year OS at 67.0%. [•] Toxicity after bortezomib-based treatment was predictable and manageable. [Copyright &y& Elsevier]

• Bakchar Bog in Klyuch catchment is fed only by rainwater. • Klyuch is an episodic river dependent on natural drainage of Bakchar Bog. • Role of groundwater in Klyuch river supply is negligibly low. • Climate change will cause decrease of runoff volume of Klyuch in summer. • Hortonian vision of infiltration and discharge is not valid in bog dominated basins. Siberian mires, especially the world's largest coherent bogs of the Great Vasyugan Mire (Tomsk Region, West Siberian Plain, Russia), play an important role in the regional hydrological cycle, global carbon balance and influence flow formation of the region's rivers. We revealed the role of natural mires in supplying water to a mire-dominated (80% of the river basin area) Siberian catchment of the Klyuch River that represents typical features of the headwater catchment of the Great Vasyugan Mire, the world's largest mire in natural and well-preserved conditions. Our research protocol involved an analysis of the electric conductivity of peat water along selected transects of the mire, analysis of groundwater levels and river discharge and electric conductivity of the river water. We used ground-penetrating radar to determine the structure of the peat. We revealed that the examined part of the mire depends solely on the rainwater supply and that minerotrophic groundwater is not present within the area of the research. Average groundwater levels within the mire in the period 2013–2018 reached 0.193 m b.g.l. We also revealed that the natural drainage of mire water does not sustain river discharge throughout the whole year. This means the Klyuch remains an intermittent river dependent on the natural outflow of the mire's waters, after exceeding the mire's critical water retention volume. Total retention volume of a mire depends on the peat's physical features and the mire's short-term response to excessive thaw and precipitation events. An analysis of river discharge duration curves demonstrated that river discharge can be sustained by the duration reaching from 0.39 up to 0.71 in a year, in dry and wet years, respectively. We concluded that in a specific hydrogeological setup of the mire–river system, natural ombrotrophic mires cannot be considered as systems with a continuous water supply and discharge stabilization. We concluded that the Hortonian vision of infiltration and discharge is not valid in bog dominated basins. In the face of climatic changes in Siberia, we foresee a decrease in the discharge volume from the headwaters of rivers and the increase of river intermittence which may affect total outflow volume, specifically in the upper Ob and Irtysh, by reducing the contribution of surface runoff. [ABSTRACT FROM AUTHOR]

Wetland buffer zones (WBZs) are riparian areas that form a transition between terrestrial and aquatic environments and are well-known to remove agricultural water pollutants such as nitrogen (N) and phosphorus (P). This review attempts to merge and compare data on the nutrient load, nutrient loss and nutrient removal and/or retention from multiple studies of various WBZs termed as riparian mineral soil wetlands, groundwater-charged peatlands (i.e. fens) and floodplains. Two different soil types ('organic' and 'mineral'), four different main water sources ('groundwater', 'precipitation', 'surface runoff/drain discharge', and 'river inundation') and three different vegetation classes ('arboraceous', 'herbaceous' and 'aerenchymous') were considered separately for data analysis. The studied WBZs are situated within the temperate and continental climatic regions that are commonly found in northern-central Europe, northern USA and Canada. Surprisingly, only weak differences for the nutrient removal/retention capability were found if the three WBZ types were directly compared. The results of our study reveal that for example the nitrate retention efficiency of organic soils (53 ± 28%; mean ± sd) is only slightly higher than that of mineral soils (50 ± 32%). Variance in load had a stronger influence than soil type on the N retention in WBZs. However, organic soils in fens tend to be sources of dissolved organic N and soluble reactive P, particularly when the fens have become degraded due to drainage and past agricultural usage. The detailed consideration of water sources indicated that average nitrate removal efficiencies were highest for ground water (76 ± 25%) and lowest for river water (35 ± 24%). No significant pattern for P retention emerged; however, the highest absolute removal appeared if the P source was river water. The harvesting of vegetation will minimise potential P loss from rewetted WBZs and plant biomass yield may promote circular economy value chains and provide compensation to land owners for restored land now unsuitable for conventional farming. Unlabelled Image • The efficiency of wetland buffer zones for nutrient retention was reviewed. • Organic and mineral soils as nutrient filters or sources were compared. • Processes driving phosphorus and nitrogen fluxes were described. • The indirect and direct impact of vegetation were unraveled. • Implications for wetland restoration and open research questions were specified. [ABSTRACT FROM AUTHOR]

Summary The ability of presynaptic dopamine terminals to tune neurotransmitter release to meet the demands of neuronal activity is critical to neurotransmission. Although vesicle content has been assumed to be static, in vitro data increasingly suggest that cell activity modulates vesicle content. Here, we use a coordinated genetic, pharmacological, and imaging approach in Drosophila to study the presynaptic machinery responsible for these vesicular processes in vivo . We show that cell depolarization increases synaptic vesicle dopamine content prior to release via vesicular hyperacidification. This depolarization-induced hyperacidification is mediated by the vesicular glutamate transporter (VGLUT). Remarkably, both depolarization-induced dopamine vesicle hyperacidification and its dependence on VGLUT2 are seen in ventral midbrain dopamine neurons in the mouse. Together, these data suggest that in response to depolarization, dopamine vesicles utilize a cascade of vesicular transporters to dynamically increase the vesicular pH gradient, thereby increasing dopamine vesicle content. [ABSTRACT FROM AUTHOR]