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Your search keyword '"García-Fernández, José M."' showing total 602 results
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602 results on '"García-Fernández, José M."'

601. Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands.

Author

Ortiz Mellet C, Defaye J, and García Fernández JM

Subjects
Carbohydrate Conformation, Carbohydrate Sequence, Cyclodextrins chemistry, Glycoconjugates chemical synthesis, Lectins chemistry, Ligands, Molecular Sequence Data, Molecular Structure, Oligosaccharides chemical synthesis, Receptors, Cell Surface chemistry, Glycoconjugates chemistry, Lectins metabolism, Oligosaccharides chemistry, Receptors, Cell Surface metabolism
Abstract

Results obtained over the past decade towards the preparation of multitopic carbohydrate architectures combining the molecular inclusion capabilities of cyclomaltooligosaccharide receptors (cyclodextrins, CDs) and the recognition properties of saccharide ligands towards biological receptors are discussed. The potential of these new sugar-based "intelligent" transporters for site specific delivery of therapeutics is outlined.

Published
2002
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602. Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

Author

García-Moreno MI, Díaz-Pérez P, Ortiz Mellet C, and García Fernández JM

Subjects
Binding, Competitive, Hydrogen-Ion Concentration, Molecular Structure, Plants enzymology, Trehalase antagonists & inhibitors, Disaccharides chemical synthesis, Enzyme Inhibitors chemical synthesis, Glycoside Hydrolase Inhibitors, Indolizines chemical synthesis, beta-Glucosidase antagonists & inhibitors
Abstract

Bicyclic azasugar glycomimetics related to castanospermine and trehazolin have been prepared from sugar carbodiimides via aminooxazoline intermediates; preliminary enzyme inhibition tests showed a marked dependence of the selectivity and potency towards alpha and beta-glucosidases upon the nature of the exocyclic substituent.

Published
2002
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