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601. Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

602. New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.

603. Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

604. Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

605. Perthamide C inhibits eNOS and iNOS expression and has immunomodulating activity in vivo.

606. Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

607. Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei.

608. Marine sponge steroids as nuclear receptor ligands.

609. Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

610. Chemical proteomics reveals heat shock protein 60 to be the main cellular target of the marine bioactive sesterterpene suvanine.

611. Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

612. Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.

613. Farnesoid X receptor: from medicinal chemistry to clinical applications.

614. Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.

615. 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.

616. Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei.

617. Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

618. Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

619. Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders.

620. Natural ligands for nuclear receptors: biology and potential therapeutic applications.

621. The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.

622. Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.

623. Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei.

624. Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

625. Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.

626. Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.

627. Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity.

628. Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei.

629. Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

630. Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

631. Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.

632. Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.

633. Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity.

634. Concise synthesis of all stereoisomers of beta-methoxytyrosine and determination of the absolute configuration of the residue in callipeltin A.

635. Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle.

636. Crellastatin A: A Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine Sponge Crella sp.

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